ライフサイエンスコーパス: hyperactivation

1 ucleus, leading to transcription factor E2F1 hyperactivation.

2 impaired ability to bind Akt, leading to Akt hyperactivation.

3 cytosolic cytokines under conditions of cell hyperactivation.

4 he cell to promote inflammasome-dependent DC hyperactivation.

5 to PP2ACalpha-knockout-induced IKKalpha/beta hyperactivation.

6 that is deficient in p25 generation and Cdk5 hyperactivation.

7 carcinoma, accounting for the epithelial YAP hyperactivation.

8 a valuable model of epilepsy caused by mTOR hyperactivation.

9 use model with lifelong innate immune system hyperactivation.

10 n drug withdrawal as a consequence of ERK1/2 hyperactivation.

11 oxc2, alone or in combination, exhibited ERK hyperactivation.

12 tween B7-2 and CD28, inducing thereby T-cell hyperactivation.

13 ent recognition by pVHL, thus leading to Akt hyperactivation.

14 f Keap1 hypomorphic mice, which possess Nrf2 hyperactivation.

15 CRC cells, in correlation with beta-catenin hyperactivation.

16 in CMT1B Schwann cells by limiting ERK/c-Jun hyperactivation.

17 al IL-10 in preventing deleterious microglia hyperactivation.

18 the molecular pathogenesis mediated by NRF2 hyperactivation.

19 s a rare, life-threatening disease of immune hyperactivation.

20 ut mice exhibit seizures and neuronal mTORC1 hyperactivation.

21 s were generally resistant to Abeta-mediated hyperactivation.

22 mutations in TSC1 or TSC2, leading to mTORC1 hyperactivation.

23 ancer development through NLRP3-inflammasome hyperactivation.

24 ) pathway genes leading to differential mTOR hyperactivation.

25 lated, 5-HT treatments resulted in myosin II hyperactivation accompanied by catastrophic cofilin-depe

26 Wnt-signaling hyperactivation, albeit in GSK-3beta independent manner,

27 ERK/MAPK hyperactivation also led to reduced corticospinal axon e

28 romotes immune dysfunction by promoting RAC2 hyperactivation, altering GEF specificity, and impairing

29 eumoniae and Escherichia coli; vi) MAIT cell hyperactivation and anergy co-utilize a signaling pathwa

30 t inhibiting either IRE1alpha or PERK led to hyperactivation and apoptotic signaling through the reci

31 2 (+/-) neurons show mTOR complex 1 (mTORC1) hyperactivation and associated increased cell body size

32 USP5 deletion causes BRAF(V600E)-induced ERK hyperactivation and cellular senescence.

33 potential cation channel 6 (TRPC6), causing hyperactivation and consequent experimental lung inflamm

34 cted hu-mice but did not rescue their immune hyperactivation and dysfunction.

35 ium levels preferentially in DLS, as well as hyperactivation and enhanced expression of N-type calciu

36 these results suggest a model of mTORC1-ATF4 hyperactivation and impaired lysosomal acidification in

37 human platelets resulted in agonist-induced hyperactivation and increased calcium entry into platele

38 ignaling pathway leading to its constitutive hyperactivation and increased expression of muscle genes

39 ound that Rheb(CA) expression induced mTORC1 hyperactivation and increased neuronal soma size and mis

40 9-mediated plasmacytoid dendritic cell (pDC)-hyperactivation and interferon-alpha production.

41 red monocyte maturation secondarily to STAT3 hyperactivation and potently reduced T cell activation,

42 from necrotic hepatocytes aggravates immune hyperactivation and promotes liver damage and possibly t

43 blockade fully reversed HIV-1-induced immune hyperactivation and rescued anti-HIV-1 immune responses

44 ic mice are worsened by astroglial NF-kappaB hyperactivation and resulting C3 elevation, whereas trea

45 ne or both alleles of TSC2 results in mTORC1 hyperactivation and specific neuronal abnormalities.

46 ncrease in glycogen synthesis through mTORC1 hyperactivation and subsequent inactivation of glycogen

47 the phenotype of a new mouse model of STING hyperactivation and the role of type I interferons in th

48 ession of CCN1 reversed the pathology of YAP hyperactivation and the subsequent aberrant growth of bl

49 ion and consequent unfolded protein response hyperactivation and tissue injury of the exocrine pancre

50 the IRF4-to-IRF8 ratio, abrogated BCR-NOTCH hyperactivation, and reduced NOTCH2 expression in cGVHD

51 Dopaminergic medication downregulates this hyperactivation, and the degree of downregulation predic

52 th mechanistic target of rapamycin complex 1 hyperactivation, and treatment of emphysema mouse models

53 compensatory processes accompanying frontal hyperactivation appear to be responsible for these alter

54 CDK4/Cyclin D kinase hyperactivation, associated with mutation of CDK4, ampli

55 -resection and ATR-dependent G(2)-checkpoint hyperactivation at all IR-doses.

56 s study demonstrates that inhibition of Drp1 hyperactivation by a Drp1 peptide inhibitor P110 is neur

57 y activation and ligand-responsive signaling hyperactivation by ACVR1-R206H.

58 Consistent with inflammasome and caspase-I hyperactivation, cardiomyocyte death and IL-18 secretion

59 nd overexpressed in several cancers, and its hyperactivation causes chronic fibrosis.

60 oteasome expression and activity, and SKN-1A hyperactivation confers resistance to the proteotoxicity

61 Its hyperactivation contributes to disease in numerous organ

62 In patients with SLE, IRF5 hyperactivation correlated with dsDNA titers.

63 stent with the observation that BMP receptor hyperactivation correlates with bone abnormalities and p

64 mulation within lysosomes, leading to mTORC1 hyperactivation, disrupted mitochondrial function, and n

65 plification is not reversible; rather ERK1/2 hyperactivation drives ZEB1-dependent epithelial-to-mese

66 ypoactivation during reward anticipation and hyperactivation during reward outcome in the striatum of

67 cting results, with both hypoactivations and hyperactivations during anticipation and outcome notific

68 s of RAS, PTEN, and TSC1, which cause mTORC1 hyperactivation, enhance immunoproteasome formation in c

69 generates the massive dentate gyrus circuit hyperactivation evident in animals during and following

70 c redox imbalance and circulating neutrophil hyperactivation have been observed in BD patients and ar

71 Immune cell hyperactivation in BALB/c mice was accompanied by a cyto

72 in Aim2 and NLRC4 inflammasome and caspase-I hyperactivation in cardiomyocytes and cardiac macrophage

73 , that disruption of this interface leads to hyperactivation in cells and to the formation of Bcl10-t

74 meostatic (hypothalamus) food motivation and hyperactivation in cognitive control (anterior cingulate

75 amic-limbic activation, but they also showed hyperactivation in cognitive control mediating dorsolate

76 The mechanisms for platelet hyperactivation in diabetes are incompletely understood.

77 t2d null mutants have robust Notch signaling hyperactivation in endocardial and endothelial cells, in

78 a not only support a primary role for mTORC1 hyperactivation in epilepsy following homozygous loss of

79 Greater hyperactivation in executive control regions in the T1D

80 t haploinsufficiency of c-Cbl results in Wnt hyperactivation in intestinal crypts and accelerates CRC

81 ation is upregulated and correlated with Akt hyperactivation in non-small-cell lung carcinoma (NSCLC)

82 in-3, EGFR ligands, or CA19-9 prevented EGFR hyperactivation in organoids.

83 Moreover, we observed that LCK hyperactivation in PPR patients upregulates the calcineu

84 Thus, multiple phagocytes are capable of hyperactivation in response to oxPAPC, with CD14 acting

85 uced IRF5 activation and reversed basal IRF5 hyperactivation in SLE immune cells.

86 demonstrate that diabetes induces NF-kappaB hyperactivation in SSCs to disrupt their ability to modu

87 sidering directionality demonstrated patient hyperactivation in the amygdala and the hippocampal/para

88 In the brain, patients showed hyperactivation in the bilateral dorsal anterior cingula

89 ally important endogenous suppressor of ASK1 hyperactivation in the pathogenesis of NASH and identify

90 rg(C/-) CD4(+) T cells contributed to B-cell hyperactivation in the spleen.

91 vation, which is important for limiting PI3K hyperactivation in Treg cells despite PTEN haploinsuffic

92 d the hypothesis that inhibition of Cdk5/p25 hyperactivation in vivo is a neuroprotective factor duri

93 t mice of Lgr4 (Lgr4 CKO) exhibit osteoclast hyperactivation (including elevation of osteoclast numbe

94 by numerous human and murine examples of ISG hyperactivation, including constitutive MDA5 activation,

95 We identified 3 distinct mechanisms of hyperactivation, including reduced binding to DEP domain

96 haracterized by the alternative-pathway (AP) hyperactivation induced by nephritic factors or compleme

97 terbalance the deleterious effects of origin hyperactivation-induced DNA damage.

98 ts as compared to normal controls, PI3K/mTOR hyperactivation interfered with primary cilia assembly (

99 To test whether IRF5 hyperactivation is a targetable function, we developed i

100 Specifically, dACC hyperactivation is consistent with abnormal promotion of

101 use models of Abeta-amyloidosis to show that hyperactivation is initiated by the suppression of gluta

102 liferation, survival and metabolism, and its hyperactivation is linked to cancer progression.

103 haC region, which is required for JAK2 V617F hyperactivation, is crucial for relaying cytokine-induce

104 mTORC1 hyperactivation leads to podocyte hypertrophy, but the d

105 These findings suggest that amygdala hyperactivation may underlie paranoia in schizophrenia.

106 llagen expression, supporting that FAK(Y397) hyperactivation may underlie the aberrant mechanobiology

107 ciated molecular dysfunction, including mTOR hyperactivation, may play a role in the development of c

108 e-dependent suppression of PI3Kdelta pathway hyperactivation (measured as phosphorylation of AKT/S6)

109 rs, cell death mechanism switches from PARP1 hyperactivation-mediated programmed necrosis with beta-l

110 Moreover, SYK hyperactivation occurs in a subset of activated microgli

111 an overabundance of Tkv protein in GSCs and hyperactivation of a downstream signal, suggesting that

112 pies transcriptional enhancers and restrains hyperactivation of a subset of these enhancers.

113 ound IL-6R into sIL-6R proteins phenocopying hyperactivation of ADAM-mediated shedding of IL-6R as si

114 These pathologies result from hyperactivation of AKT and consequent deregulation of me

115 Loss of CXADR led to hyperactivation of AKT and sensitized cells to TGFbeta1-

116 Hyperactivation of Akt is associated with oncogenic chan

117 Loss of Kdm5b abrogated the hyperactivation of AKT signaling by decreasing P110alpha

118 potential target, IGF-1 receptor, along with hyperactivation of Akt signaling, in miR-133a-deficient

119 propose that targeted inhibition of PTEN and hyperactivation of AKT triggers a checkpoint for the eli

120 of PTEN in human pre-B ALL cells resulted in hyperactivation of AKT, activation of the p53 tumor supp

121 Cbl/Cbl-b DKO in mammary organoids leads to hyperactivation of AKT-mTOR signaling with depletion of

122 in which loss of DNA-PKcs function leads to hyperactivation of ATM and amplification of the p53 resp

123 in a constant activation of AMPK leading to hyperactivation of autophagy during oxidative stress.

124 espread genomic instability, mitotic arrest, hyperactivation of autophagy, and cell death.

125 mily members Tet2 and Tet3 in B cells led to hyperactivation of B and T cells, autoantibody productio

126 ared to controls, PD_OFF showed compensatory hyperactivation of bilateral putamen and posterior insul

127 e show that elevation of glial Ca(2+) causes hyperactivation of calcineurin-dependent endocytosis and

128 istimerin and lupeol considerably diminished hyperactivation of capacitated spermatozoa.

129 We also show that low-temperature-induced hyperactivation of caspase-1 by NLRC4-H443P is due to lo

130 titutive activity, the mechanism involved in hyperactivation of caspase-1 by NLRC4-H443P upon exposur

131 yndrome (FCAS) characterized by cold-induced hyperactivation of caspase-1, enhanced interleukin-1beta

132 of Cancer Cell, Ishizawa et al. describe the hyperactivation of ClpP as a strategy in cancer therapy.

133 of SIV infection, and this defect is due to hyperactivation of cofilin and inefficient actin polymer

134 CD55 deficiency with hyperactivation of complement, angiopathic thrombosis, a

135 se requires condensin and coincides with the hyperactivation of condensin DNA supercoiling activity.

136 and cyclin D1 overexpression that results in hyperactivation of cyclin-dependent kinase 4 and 6 (CDK4

137 ipids, a hallmark of dying cells, triggering hyperactivation of dendritic cells and macrophages.

138 Hyperactivation of dopamine neurons generates behavioral

139 In ASD, FER deficits correlated with hyperactivation of dorsal stream regions and increased e

140 HFD-induced obesity is characterized by a hyperactivation of EGCs and is involved in the developme

141 Hyperactivation of ENaC, which creates an osmotic gradie

142 We conclude that global hyperactivation of enhancers drives naive pluripotency,

143 sulted in rapid and severe pancreatitis with hyperactivation of epidermal growth factor receptor (EGF

144 revealed that these MORC2 variants result in hyperactivation of epigenetic silencing by the HUSH comp

145 in FMR1 abolish FMRP expression, leading to hyperactivation of ERK and mTOR signaling upstream of mR

146 overexpression of oncogenic Nras, leading to hyperactivation of ERK1/2 signaling.

147 MN were associated with greater increases in hyperactivation of executive control regions (T1D: r = 0

148 y high prevalence of BRAF/NRAS mutations and hyperactivation of extracellular signal-regulated kinase

149 The decrease of CAV1 contributed to the hyperactivation of fibrogenesis-associated RUNX2, a tran

150 module and defects cause hyper-resection and hyperactivation of G(2)-checkpoint at all doses examined

151 conferred by these GEFs in CTCs implies that hyperactivation of G-protein signaling by these GEFs is

152 This germline defect is suppressed by hyperactivation of glp-1 or disruption of genes downstre

153 through mTORC1 activation, which results in hyperactivation of glycogen synthase kinase 3beta (GSK3b

154 Hyperactivation of GRM1 in malignant melanoma is an onco

155 IGFBP5 expression, which, in turn, leads to hyperactivation of IGF-1R signaling.

156 arises primarily through antigen-independent hyperactivation of immune pathways.

157 order to prevent clearance, while later, the hyperactivation of inflammation contributes to the progr

158 fector T cells and the associated downstream hyperactivation of inflammatory phagocytes, which are ca

159 Hyperactivation of innate immunity has been implicated i

160 ve protein homeostasis (proteostasis) due to hyperactivation of insulin-sensitive pathways such as pr

161 Artificial hyperactivation of IPS neurons caused a large increase i

162 d hepatocellular carcinoma primarily through hyperactivation of its downstream effector, YAP.

163 synthase kinase (GSK)3beta overactivity and hyperactivation of its downstream mitogen-activated prot

164 abrogated by other oncogenic events, such as hyperactivation of its endogenous repressors MDM2 or MDM

165 corticosterone levels driven by hypothalamic hyperactivation of Jnk signaling.

166 However, permanent hyperactivation of kinases, for instance, downstream of

167 Hyperactivation of mitogen-activated protein kinase kina

168 Conversely, the absence of LDs results in hyperactivation of MLX target genes.

169 TSC2 deficiency leads to hyperactivation of mTOR Complex 1 (mTORC1), a master reg

170 ding the TSC1/TSC2 complex, resulting in the hyperactivation of mTOR- and Raf/MEK/MAPK-dependent sign

171 Hyperactivation of mTORC1 in SZT2-deficient cells could

172 bolic effects observed upon loss of TSC1 and hyperactivation of mTORC1 in the liver.

173 Hyperactivation of mTORC1 via TSC1 gene deletion in chon

174 ous sclerosis genes TSC1 or TSC2) are due to hyperactivation of mTORC1-mediated protein synthesis(1,2

175 O sensitize leukemic cells to R-2HG, whereas hyperactivation of MYC signaling confers resistance that

176 ssociating with a downregulation of GABA and hyperactivation of neighboring excitatory neurons.

177 FR induces a signaling cascade that leads to hyperactivation of NFkB and a resultant aggressive cell

178 d display elevated serum AST and ALT levels, hyperactivation of NKT cells, and enhanced IFN-gamma, TN

179 and reactive oxygen species, thus preventing hyperactivation of NLRP3 inflammasome.

180 These data indicate that hyperactivation of Notch and Wnt signaling is independen

181 To investigate how hyperactivation of Notch in larval neuroblasts leads to

182 Recent studies show hyperactivation of Nrf2 causes osteopenia in Keap1(-/-)

183 naling, is an NRF2 target gene, and as such, hyperactivation of NRF2 impairs Hh signaling.

184 toxic, and metabolic stress in normal cells, hyperactivation of NRF2 is oncogenic, although the detai

185 induced by SARS-CoV-2 infection may trigger hyperactivation of P2X7 receptors leading to NLRP3 infla

186 Instead, the loss of Casp-8 caused hyperactivation of p38 MAPK downstream of receptor-inter

187 Hdac8-deficient LT-HSCs displayed hyperactivation of p53 and increased apoptosis under gen

188 KO dorsal motor nucleus of vagus resulted in hyperactivation of parasympathetic signaling-induced bro

189 on, display developmental defects resembling hyperactivation of Pc.

190 However, hyperactivation of pDC can cause life-threatening autoim

191 histone modification enzyme KDM5B determine hyperactivation of PI3K/AKT signaling in prostate cancer

192 xide formation, which damages DNA and causes hyperactivation of poly(ADP-ribose) polymerase, resultin

193 he XRCC1 partner protein PNKP and implicates hyperactivation of poly(ADP-ribose) polymerase/s as a ca

194 ed increases in appetite are associated with hyperactivation of putative mesocorticolimbic reward cir

195 Here, we describe how the hyperactivation of Rac1 via the P29S mutation (Rac1(P29S

196 Similarly, hyperactivation of RagA did not affect HSC function.

197 regressing tumour microenvironment revealed hyperactivation of several signalling pathways, most pro

198 state, and RNA sequencing analyses revealed hyperactivation of several T lymphocyte-associated immun

199 SAN pacemaker activity produces intermittent hyperactivation of SK channels, leading to arrhythmic pa

200 1-2 mutants, leading to its accumulation and hyperactivation of SnRK1 signaling.

201 In addition, hyperactivation of specificity protein 1 transcription f

202 Animal studies also suggest that hyperactivation of Src, alteration of autophagy and a mi

203 se model of spontaneous osteopenia caused by hyperactivation of STAT1/3 signaling downstream of gp130

204 tes SnRK1 signaling and prevents detrimental hyperactivation of stress responses.

205 InFlo was the only algorithm to identify hyperactivation of the cAMP-CREB1 axis as a key mechanis

206 notype results from elevated cAMP levels and hyperactivation of the cAMP-dependent protein kinase (PK

207 ooth germ of Smad7 null mice, indicating the hyperactivation of the canonical TGF-beta signaling.

208 induced endothelial dysfunction involves the hyperactivation of the CAPN proteolytic system.

209 antigen presentation capacity and subsequent hyperactivation of the CD8(+) T-cell response.

210 Moreover, we found a hyperactivation of the CDK4/6-EZH2 pathway in human and

211 alled forks results in fork restart defects, hyperactivation of the DNA damage signal, accumulation o

212 PTSD youth showed hyperactivation of the dorsal anterior cingulate cortex

213 e conductance regulator (CFTR) combined with hyperactivation of the epithelial sodium channel (ENaC).

214 ery symptoms were associated with widespread hyperactivation of the executive network.

215 ymptoms and those with no mood symptoms) was hyperactivation of the hippocampus/amygdala, when contro

216 JAK1 in MM cell lines, which contributes to hyperactivation of the IL-6-JAK-STAT3 signaling importan

217 uncontrolled growth and causes the systemic hyperactivation of the inflammatory response.

218 We conclude that defects associated with hyperactivation of the insulin signaling pathway are unl

219 Here we show that hyperactivation of the interleukin 1 pathway, through ei

220 owth arrest and premature senescence through hyperactivation of the IRE1alpha RNase.

221 s by E2A-PBX1 in pre-B-ALL, which results in hyperactivation of the key oncogenic effector enzyme PLC

222 Hyperactivation of the mechanistic target of rapamycin (

223 splay alterations in proliferation for which hyperactivation of the mechanistic target of rapamycin (

224 hosphorylation of cell division proteins via hyperactivation of the Mn-dependent protein phosphatase

225 Hyperactivation of the mTOR pathway impairs hematopoieti

226 Hyperactivation of the mTOR signaling is observed in vir

227 c2 in zebrafish resulted in heterotopias and hyperactivation of the mTorC1 pathway in pallial regions

228 The latter has been coupled to hyperactivation of the nonselective cation channel, tran

229 ncrease their antioxidant production through hyperactivation of the NRF2 pathway, which promotes tumo

230 panel of stemness-associated genes and drove hyperactivation of the nuclear factor kappa B p65 pathwa

231 ed, by either rare disruptive events causing hyperactivation of the pathway, or through the collectiv

232 phosphoinositide 3-kinase (PI3K), result in hyperactivation of the PI3K-AKT-mechanistic target of ra

233 PIK3CA-related overgrowth spectrum and cause hyperactivation of the PI3K-AKT-mTOR pathway.

234 Hyperactivation of the PI3K-mTOR signaling network, via

235 Conversely, Nqo1 overexpression caused hyperactivation of the PI3K/Akt and MAPK/ERK pathways an

236 etic and chemical approaches, we showed that hyperactivation of the protease selectively kills cancer

237 l cognitive performance through compensatory hyperactivation of the putamen.

238 Hyperactivation of the receptor tyrosine kinase c-Met an

239 el to examine the pathogenic contribution of hyperactivation of the STAT3 arm of IL6 signaling on KRA

240 s treat the disease, fostering the view that hyperactivation of the thiazide-sensitive sodium-chlorid

241 Hyperactivation of the Wnt pathway via Apc inactivation

242 cells are major sources of cancer following hyperactivation of the WNT pathway(2).

243 t ciliation could also be suppressed through hyperactivation of the YAP/TAZ pathway, indicating a pot

244 y of the ATR kinase, yet it does not lead to hyperactivation of this key checkpoint protein.

245 Hyperactivation of this region during elevated state anx

246 ly released by the thyroid, but in states of hyperactivation of thyroid-stimulating hormone receptors

247 can cause VM and induce a ligand-independent hyperactivation of TIE2.

248 form spontaneously to myofibroblasts through hyperactivation of transforming growth factor beta (TGF-

249 Hyperactivation of transforming growth factor-beta (TGF-

250 ns of EAC vs nondysplastic BE tissues showed hyperactivation of transforming growth factor-beta (TGFB

251 tone marks results in global transcriptional hyperactivation of transposable elements with modest eff

252 nd NUCB2 have revealed that GPCR-independent hyperactivation of trimeric G proteins can fuel metastat

253 he differentiation inhibition coincides with hyperactivation of Wg signaling caused by the accumulati

254 tated the TCF4-chromatin interaction and the hyperactivation of WNT, thus conferring a malignant phen

255 Conversely, experimental hyperactivation of YAP in peritumoral hepatocytes trigge

256 , our findings provide evidence that genetic hyperactivation of YAP unbalances the YAP-SOX9 feedback

257 Loss of compensatory hyperactivation on dopaminergic medication correlated wi

258 talloenzymes are particularly susceptible to hyperactivation or mismetallation, suggesting the need f

259 igin for cSCC, and that RAS/RAF/MAPK pathway hyperactivation or Tp53 mutation, coupled with loss of T

260 ines the multiple mechanisms leading to Rac1 hyperactivation, particularly focusing on emerging parad

261 y and also uncover a mechanism by which NRF2 hyperactivation promotes tumor progression via primary c

262 els of sepsis, conditions that promoted cell hyperactivation resulted in inflammation but not lethali

263 s, and RhoA inhibition mimics the osteoclast hyperactivation resulting from Gna13-deficiency.

264 h MS, N-back accuracy improved while frontal hyperactivation (seen at baseline relative to HCs) disap

265 Sites of Chm7 hyperactivation show fenestrated sheets at the INM and p

266 as a mechanism contributing to granule cell hyperactivation specifically during early epilepsy devel

267 ompartment in the spleen and disengaging the hyperactivation state in the memory T subsets, most nota

268 eover, altering the timing and degree of p53 hyperactivation substantially affects the phenotypic out

269 horylation by PKA and PKC, leading to enzyme hyperactivation that abnormally lowers cAMP levels.

270 iferative syndrome, a disease driven by mTOR hyperactivation that responds to sirolimus treatment.

271 tant compromised CDH1 binding, allowing CDH1 hyperactivation, thereby hastening degradation of its su

272 in the JAK1 tyrosine kinase that results in hyperactivation, thereby leading to skin serine protease

273 e broadly, the consequences of CD8(+) T-cell hyperactivation, thereby paving the way for clinical int

274 hibit the Wnt/beta-catenin signaling pathway hyperactivation through blocking UBE2T-mediated degradat

275 MAPK pathway hyperactivation (through Braf(V600E) or Kras(G12D) knock

276 as contraceptive compounds by averting sperm hyperactivation, thus preventing fertilization.

277 A previous report linked hyperactivation to deficient amygdala habituation to rep

278 interaction, PTSD youth showed dorsal (d)ACC hyperactivation to happy faces relative to healthy youth

279 The mechanism linking CD8(+) T-cell hyperactivation to pathology is controversial, with exce

280 The potential contribution of Rac hyperactivation to resistance to anticancer agents, incl

281 CD8(+) T cells couples Janus kinase 2 (JAK2) hyperactivation to the phosphorylation of CREB-binding p

282 activation in executive circuitry and limbic hyperactivation to threat could reflect partly independe

283 ients can be pharmacologically directed from hyperactivation toward maturity.

284 s a circulating enzyme that reduces platelet hyperactivation, triggers both insulin secretion and deg

285 at WASp deficiency differentially influences hyperactivation versus inhibition of both CDC42:ERK1/2 a

286 Moreover, Akt hyperactivation was accompanied by hyperphosphorylation

287 Akt hyperactivation was confirmed in individual neurons of a

288 cer cells in a paracrine fashion, whereas no hyperactivation was detectable in cell lines harboring m

289 orking memory functional MR imaging studies, hyperactivation was found in the male MTBI group and hyp

290 NRF2 hyperactivation was necessary for proliferation and surv

291 In younger patients, initial hyperactivation was seen in the right precuneus and righ

292 ral or knock-in PIK3CA mutations and/or PI3K hyperactivation, we show that PIK3CA-E545K mutations (fo

293 ln- and ConA-induced liver injury and immune hyperactivation, whereas exogenous gp96 aggravated the s

294 ll lymphoma and are associated with H3K27me3 hyperactivation, which contributes to lymphoma pathogene

295 Furthermore, HIV-1-induced immune hyperactivation, which is a prognosticator of disease pr

296 nized that phagocytes can achieve a state of hyperactivation, which is defined by their ability to se

297 y altered motility and are unable to undergo hyperactivation, which is essential for fertilization.

298 NKKY101 cells on rapamycin and observed TOR1 hyperactivation, which leads to Hsp90-dependent calcineu

299 n vertebrate animal models indicates pathway hyperactivation with a concomitant increase in cell and

300 plastic dedifferentiation, as well as mTORC1 hyperactivation with reduced Akt phosphorylation.