ライフサイエンスコーパス: hyperexcitable

1 nglion (DRG) and trigeminal ganglion neurons hyperexcitable.

2 uggested that A863P could render DRG neurons hyperexcitable.

3 nervous system because immature circuits are hyperexcitable.

4 e dorsal raphe nucleus (DRN), rendering them hyperexcitable.

5 However, weak responders (37%) remained hyperexcitable.

6 ypoexcitable, whereas pyramidal neurons were hyperexcitable.

7 derived from lithium responder patients were hyperexcitable.

8 pal hippocampal neurons become intrinsically hyperexcitable.

9 ing other brain territories that are already hyperexcitable.

10 orsal root ganglion (DRG) nociceptors become hyperexcitable.

11 ts of BD patients are electrophysiologically hyperexcitable.

12 ons render dorsal root ganglia (DRG) neurons hyperexcitable.

13 striatal neurons in mHTT glial chimeras are hyperexcitable.

14 V1.7 make dorsal root ganglion (DRG) neurons hyperexcitable.

15 rotonin neurons at postnatal day 4 (P4) were hyperexcitable.

16 nels within DRG neurons rendered these cells hyperexcitable.

17 changes in HCN channel expression and became hyperexcitable.

18 ts render dorsal root ganglion (DRG) neurons hyperexcitable.

19 ations rendered dorsal root ganglion neurons hyperexcitable.

20 t R185H renders dorsal root ganglion neurons hyperexcitable.

21 renders DRG and trigeminal ganglion neurons hyperexcitable.

22 tive) neurons, adding further evidence for a hyperexcitable 5-HT system.

23 itability, resulting in young, intrinsically hyperexcitable ABGCs receiving disproportionately large

24 ave shown that spinal sensory neurons become hyperexcitable after axonal injury, and electrophysiolog

25 Spinal motoneurons become hyperexcitable after SCI, but the plastic responses of l

26 These neurons become chronically hyperexcitable after SCI, generating ongoing electrical

27 imuli that directly induce neurons to become hyperexcitable also induced HSV-1 reactivation.

28 the process by which a normal brain becomes hyperexcitable and capable of generating spontaneous rec

29 ndings suggest that CGRP interneurons become hyperexcitable and contribute either to ascending circui

30 ons of heterozygous and homozygous mice were hyperexcitable and generated long-lasting depolarizing p

31 cal slices from drug-resistant patients made hyperexcitable and hypersynchronous by Mg(2+)-free media

32 ns is poorly controlled, oscillating between hyperexcitable and hypoexcitable states during disease p

33 o their sodium currents, alternating between hyperexcitable and hypoexcitable states.

34 Hilar ectopic granule cells (HEGCs) are hyperexcitable and may therefore increase circuit excita

35 ns, and renders dorsal root ganglion neurons hyperexcitable and superior cervical ganglion neurons hy

36 LM may render epileptic hippocampal networks hyperexcitable and susceptible to glutamate-mediated exc

37 types of neurons, it renders sensory neurons hyperexcitable and sympathetic neurons hypoexcitable.

38 ngly, the visual cortex of NARP(-/-) mice is hyperexcitable and unable to express ocular dominance pl

39 n of K(ATP) by glibenclamide, The effects of hyperexcitable and underexcitable islets on glucotoxicit

40 ns within the repeated cocaine ensemble were hyperexcitable, and their optogenetic excitation was suf

41 However, MECII stellate cells remained hyperexcitable, and this was further exacerbated by an i

42 7, which render dorsal root ganglion neurons hyperexcitable, are present in a substantial proportion

43 rons with a deficient MPC were intrinsically hyperexcitable as a consequence of impaired calcium home

44 me progressively less excitable, rather than hyperexcitable, as mossy fiber sprouting progressed and

45 pyramidal neurons in mPFC layers II/III were hyperexcitable at baseline but hypoexcitable following D

46 We further show that this hyperexcitable behavior can be rescued by pharmacologica

47 The hyperexcitable blink reflex may be a maladaptive consequ

48 quence relationship may offset a potentially hyperexcitable blink reflex, thereby reducing the likeli

49 -wave discharges and optogenetically induced hyperexcitable bursts in vivo were present in a cortical

50 that SST interneurons from mutant mice were hyperexcitable but hypersensitive to action potential fa

51 n to make dorsal root ganglion (DRG) neurons hyperexcitable, but different pain profiles (affected so

52 ant epileptic patients made hypersynchronous/hyperexcitable by elevated potassium or inhibition of GA

53 epileptogenic foci acting upon a temporarily hyperexcitable central autonomic network.

54 uman to reduce pain sensation by normalizing hyperexcitable central neural activity.

55 t the mechanisms that render the hippocampus hyperexcitable chronically (in epilepsy) or acutely (in

56 /3 pyramidal neurons as the key component of hyperexcitable circuitry.

57 pal CA3-CA1 synapses, as well as suppressing hyperexcitable circuits in vitro and in vivo.

58 neuronal function, aberrant plasticity, and hyperexcitable circuits.

59 firing shows that Scn1b null DRG neurons are hyperexcitable compared with WT.

60 hus, uIPSPs can increase neuronal gain under hyperexcitable conditions, and this effect is probably d

61 We show that, under hyperexcitable conditions, slices from the epileptic den

62 CA3 pyramidal cell activity under basal and hyperexcitable conditions.

63 in cultured hippocampal neurons cultured in hyperexcitable conditions.

64 of delayed responses can identify regions of hyperexcitable cortex in the human brain.

65 Together these changes resulted in hyperexcitable dendrites with enhanced dendritic AP back

66 in these interneuron classes showed markedly hyperexcitable dentate gyrus field-potential responses t

67 only in neuropathic pain but also in other "hyperexcitable" diseases of the nervous system such as s

68 d primary driver of DRG neuronal firing, and hyperexcitable DRG neurons expressing a gain-of-function

69 letal muscle from transgenic R6/2 HD mice is hyperexcitable due to decreased chloride and potassium c

70 studies indicate that the migraine brain is hyperexcitable due to enhanced excitation or reduced inh

71 Our model suggests the TSNC may become hyperexcitable due to loss of tonic inhibition by functi

72 st, iSPNs, but not dSPNs, were intrinsically hyperexcitable due to reduced function of the inwardly r

73 ylase (TH)-positive neurons (LC(spinal)) are hyperexcitable during morphine withdrawal, elevating cer

74 Motor neurons become hyperexcitable during progression of amyotrophic lateral

75 pike probability, suggesting an unstable and hyperexcitable early cortical network.

76 rge that the dendrites of motoneurons become hyperexcitable, enhancing ionotropic inputs by fivefold

77 te gyrus (DG) granule neurons were extremely hyperexcitable, exhibiting increased sodium and potassiu

78 normalize with a CaV 2.1 gating modifier in hyperexcitable FHM1 mice.

79 ers of neocortically derived neurons exhibit hyperexcitable firing activity and may be a source of he

80 transient (I(A))-type potassium current and hyperexcitable firing.

81 s are likely to influence the development of hyperexcitable foci in posttraumatic limbic circuits.

82 GABAergic inhibitory neurons, which remained hyperexcitable following chronic M-channel blockage.

83 that noise-exposed bushy cells would remain hyperexcitable for a period after returning to normal qu

84 When the LNVs are made hyperexcitable, free-running behavioral rhythms decompos

85 ragile X syndrome model mutant zebrafish are hyperexcitable from the earliest phases of spontaneous b

86 slices indicate that SCA1-KI IO neurons are hyperexcitable, generating spike trains in response to m

87 prived S1BC that project to intact S1BC were hyperexcitable, had stronger responses and reduced inhib

88 ividual genes involved in converting neurons hyperexcitable have been identified, including early gro

89 We found that hyperexcitable hypocretin/orexin (Hcrt/OX) neurons drive

90 Hyperexcitable immature neurons may contribute to disrup

91 ate that dentate granule cells are maximally hyperexcitable immediately after SE, prior to mossy fibe

92 e conclude that cortical networks in FXS are hyperexcitable in a brain state-dependent manner during

93 te cells of the entorhinal cortex, which are hyperexcitable in animal models of temporal lobe epileps

94 so than somata, of hippocampal neurons were hyperexcitable in mice overexpressing Abeta.

95 5-HT neurons were also hyperexcitable in P301L-tau(DRN) mice, and there was an

96 mutually excitatory CA3 pyramidal cells are hyperexcitable in these rats.

97 gating of Na(V)1.8 can render human iPSC-SNs hyperexcitable, in a first-of-its-kind investigation of

98 polarizing direction, and render DRG neurons hyperexcitable, in I-SFN patients with no mutations of S

99 ency-discrimination hyperacuity is caused by hyperexcitable interneurons in the ACx.

100 In contrast, hyperexcitable K(ATP)-KO islets lost insulin content in

101 Blocking hyperexcitable K(Na)1.1 channels with quinidine, a class

102 Hyperexcitable, learning-enhanced, and epileptic seizure

103 ed motor function, motor unit pathology, and hyperexcitable MNs.

104 ncreased excitability further in the already hyperexcitable -/- MNTB neurons, suggesting that -/- IKL

105 mouse that displays motor impairments and a hyperexcitable motor phenotype compatible with dystonia.

106 underlying APPL-dependent synapse formation, hyperexcitable mutants, which also alter synaptic growth

107 In hyperexcitable Nav1.7L858H-expressing neurons, partial N

108 alpha(-/-) mice result in the formation of a hyperexcitable network but act in part neuroprotectively

109 citatory synaptic transmission, leading to a hyperexcitable network state that is characterized by th

110 static plasticity, both of which result in a hyperexcitable network state.

111 lepsy is based on the reflex activation of a hyperexcitable network that subserves the function of sp

112 ise mechanisms underlying the development of hyperexcitable networks are largely unknown.

113 study was to analyze the conditions in which hyperexcitable networks can generate either IESs or FRs

114 taneous activity is generated in developing, hyperexcitable networks.

115 sy, a neurological disorder characterized by hyperexcitable networks.

116 d thereby contribute to the development of a hyperexcitable neuronal network have been elucidated.

117 Hyperexcitable neuronal networks are mechanistically lin

118 , and neurophysiological factors, leading to hyperexcitable neuronal states, central sensitization an

119 o the pathways that lead from mutant gene to hyperexcitable neurones.

120 nfluence of human microglia on intrinsically hyperexcitable neurons carrying epilepsy-associated path

121 on, may offer a way of inhibiting only those hyperexcitable neurons responsible for clinical problems

122 re, microglia suppressed the excitability of hyperexcitable neurons, suggesting a potential beneficia

123 ory-induced seizure activity in mutants with hyperexcitable neurons.

124 int of the brain model, coupled with locally hyperexcitable node dynamics of the epileptogenic networ

125 visually triggered in widespread regions of hyperexcitable occipital cortex.

126 We found that BD CA3 neurons were hyperexcitable only when they were derived from patients

127 , to characterize electrographic seizure and hyperexcitable pattern predictors in each group and dete

128 8; p = 0.012); insular involvement predicted hyperexcitable patterns (odds ratio, 4.88; CI, 1.36-17.5

129 nt did not affect electrographic seizures or hyperexcitable patterns in either group.

130 Hyperexcitable patterns included the following: periodic

131 Hyperexcitable patterns were more frequent in the lobar

132 ified predictors of electrographic seizures, hyperexcitable patterns, and poor outcomes (score of 1-2

133 extent to which it is possible to rescue the hyperexcitable phenotype characteristic of the para(bss)

134 owever, immature (day 40) C9-MNs exhibited a hyperexcitable phenotype concurrent with increased relea

135 emonstrate that acute withdrawal engenders a hyperexcitable phenotype of PVN(CRH) neurons in females

136 g in utero electroporation also results in a hyperexcitable phenotype similar to the conditional knoc

137 modulin 5' and 3' UTRs also induces the same hyperexcitable phenotype.

138 on 14 SCI subjects with velocity-dependent, hyperexcitable plantarflexors.

139 been proposed as crucial to development of a hyperexcitable, potentially seizure-prone circuit.

140 y increases network activity, resulting in a hyperexcitable, potentially seizure-prone circuit.

141 ased innervation of cortical engram cells by hyperexcitable PV interneurons, suggesting that dysfunct

142 ed (small vs large), spatial distribution of hyperexcitable pyramidal cells (clustered vs uniform), a

143 on of the extra K+ channel gene results in a hyperexcitable rather than a hypoexcitable phenotype.

144 a(v)1.7 renders dorsal root ganglion neurons hyperexcitable, reducing the current threshold for gener

145 Hyperexcitable reflex blinks are a cardinal sign of Park

146 elid with reduced motility evoked bilateral, hyperexcitable reflex blinks, whereas contralateral SO s

147 be partly responsible for the appearance of hyperexcitable reflexes following spinal cord injury (SC

148 a result, these Kcnq2-deficient neurons are hyperexcitable, responding to current injections with an

149 e slices, cerebellar granule cells exhibit a hyperexcitable response to membrane depolarizations.

150 iving mossy cells play a crucial role in the hyperexcitable responses of the post-traumatic dentate g

151 ncement of EPSCs in computer simulations and hyperexcitable responsiveness to innocuous and noxious p

152 entry of primary nociceptors into a chronic hyperexcitable-SA state that may provide a useful therap

153 amplifications of migraine are attributed to hyperexcitable sensory circuits, but a detailed understa

154 Hyperexcitable SGCs could augment dentate throughput to

155 This delayed maturation resulted in hyperexcitable SGNs with immature firing characteristics

156 that MeCP2 null LC neurons are electrically hyperexcitable, smaller in size, and express less of the

157 suggest that this change makes these neurons hyperexcitable so that they act as pain amplifiers and g

158 nced Hoffman reflex (H-reflex), indicating a hyperexcitable spinal cord.

159 Hyperexcitable spinal neurons show reduced thresholds, g

160 primary role in driving SCI-nociceptors to a hyperexcitable state and contributes to chronic neuropat

161 hNR1 antibody drives cortical networks to a hyperexcitable state and disrupts mechanisms stabilizing

162 a major role in driving SCI-nociceptors to a hyperexcitable state and for promoting their spontaneous

163 responsible for driving SCI-nociceptors to a hyperexcitable state and for triggering their spontaneou

164 sensory neurons, triggering in nociceptors a hyperexcitable state and spontaneous activity (SA) that

165 A hyperexcitable state and spontaneous activity of nocicep

166 A hyperexcitable state and spontaneous activity of SCI-noc

167 Overall, our findings suggest a hyperexcitable state in BLA-vSub specific inputs as well

168 The net result is a shift toward a hyperexcitable state in dBNST activity.

169 riven excitatory-inhibitory (E/I) ratio to a hyperexcitable state in dBNST.

170 ation were not attributable to a generalized hyperexcitable state in noise-exposed animals.

171 ted Kv3.4 channel has been implicated in the hyperexcitable state of dorsal root ganglion (DRG) neuro

172 ippocampal circuitries may contribute to the hyperexcitable state of the DA system that is present in

173 eceptor so that abrupt withdrawal produces a hyperexcitable state that leads to seizures, delerium tr

174 channels) play a key role in the sensitized (hyperexcitable) state of nociceptive sensory neurons (no

175 ion, and the homeostatic control of abnormal hyperexcitable states.

176 results in clonal transformants that exhibit hyperexcitable swimming behaviors reminiscent of certain

177 How hyperexcitable sympathetic circuitry forms is unknown, b

178 death, elevated extracellular glutamate, and hyperexcitable synaptic activity.

179 and colleagues provided strong evidence that hyperexcitable thalamocortical networks drive remifentan

180 c granule cells from epileptic rats are more hyperexcitable than granule cells in the GCL.

181 Granule cells were maximally hyperexcitable to afferent stimulation immediately after

182 igra pars compacta neurons created rats with hyperexcitable trigeminal reflex blinks but normally exc

183 he trigeminal reflex blinks of subjects with hyperexcitable trigeminal reflex blinks caused by Parkin

184 ock neurons was tested by rendering the LNVs hyperexcitable via transgenic expression of a low activa

185 nt neurons, urethral afferent neurons may be hyperexcitable well into DM progression.

186 ny newborn DGCs integrate aberrantly and are hyperexcitable, whereas others may integrate normally an

187 firing frequency, whereas PV neurons became hyperexcitable with a lower rheobase current and higher

188 vs. CONTROLS: Scn8a(N1768D/+) myocytes were hyperexcitable, with a lowered threshold for AP firing,

189 rments, stellate cells in MEC became further hyperexcitable, with increased excitability exacerbated

190 ly effective in modulating the activities of hyperexcitable young neurons, which may have important i