ライフサイエンスコーパス: hyperhomocysteinemia

1 iron deficiency anemia, thrombocytosis, and hyperhomocysteinemia.

2 e the most common cause of severe hereditary hyperhomocysteinemia.

3 LF) diet for 6 to 8 months to produce graded hyperhomocysteinemia.

4 eta-synthase (Cbs)-heterozygous mice develop hyperhomocysteinemia.

5 uced the prevalence of folate deficiency and hyperhomocysteinemia.

6 ue to vegetarianism is increasing and causes hyperhomocysteinemia.

7 hepatic necroinflammation and apoptosis, and hyperhomocysteinemia.

8 uced activity, increased thermolability, and hyperhomocysteinemia.

9 hionine intake with B vitamin deficiency and hyperhomocysteinemia.

10 s of excess dietary methionine from those of hyperhomocysteinemia.

11 al macrophages was higher in the presence of hyperhomocysteinemia.

12 tion of placebo and after methionine-induced hyperhomocysteinemia.

13 associated with poor cognition, anemia, and hyperhomocysteinemia.

14 n peritoneal macrophages were not changed by hyperhomocysteinemia.

15 ncreased incidence of stroke associated with hyperhomocysteinemia.

16 ized by a plethora of vascular disorders and hyperhomocysteinemia.

17 s in young patients with iron deficiency and hyperhomocysteinemia.

18 on may contribute to vascular dysfunction in hyperhomocysteinemia.

19 ontribute to endothelial dysfunction in mild hyperhomocysteinemia.

20 o inactivating nitric oxide in chronic, mild hyperhomocysteinemia.

21 ively low blood folate levels and consequent hyperhomocysteinemia.

22 iciency in the elderly and its role in their hyperhomocysteinemia.

23 th elevated levels of homocysteine, known as hyperhomocysteinemia.

24 thogenesis of both homocystinuria and modest hyperhomocysteinemia.

25 ence of this mutation is not associated with hyperhomocysteinemia.

26 H2S in the thrombotic events associated with hyperhomocysteinemia.

27 mmation, and activation of fibrogenesis) and hyperhomocysteinemia.

28 -induced hearing loss associated with plasma hyperhomocysteinemia.

29 -beta-synthase (cbs) were used as a model of hyperhomocysteinemia.

30 steatosis or UPR activation despite inducing hyperhomocysteinemia.

31 macrovascular occlusion in individuals with hyperhomocysteinemia.

32 ocysteine; hence, their malfunction leads to hyperhomocysteinemia.

33 functional changes in cerebral arterioles in hyperhomocysteinemia.

34 sion of cochlear methionine cycle genes, and hyperhomocysteinemia.

35 regulation and has possible implications for hyperhomocysteinemia.

36 ugmentation was significantly blunted during hyperhomocysteinemia (1.06 +/- 1.00 ml/min/g vs. 0.58 +/

37 hial artery vasodilation was impaired during hyperhomocysteinemia (4.4 +/- 2.6% vs. 2.6 +/- 2.3%, pla

38 been observed in renal disease patients with hyperhomocysteinemia, a cardiovascular disease risk fact

39 Hyperhomocysteinemia, a condition that recent epidemiolo

40 Mild hyperhomocysteinemia, a putative risk factor for arterio

41 Mild hyperhomocysteinemia, a putative risk factor for atherot

42 instead, these inadequacies could result in hyperhomocysteinemia, a recently identified risk factor

43 Hyperhomocysteinemia, a risk factor for CAD, may cause a

44 lymorphism is a genetic determinant for mild hyperhomocysteinemia, a risk factor for cardiovascular d

45 m is the most frequent genetic cause of mild hyperhomocysteinemia, a risk factor for cardiovascular d

46 We tested the hypothesis that hyperhomocysteinemia accelerates arterial thrombosis in

47 tomography (PET) to test the hypothesis that hyperhomocysteinemia adversely effects coronary microvas

48 o diet-induced hyperhomocysteinemia and that hyperhomocysteinemia alters tissue methylation capacity

49 Mice fed the MCD diet developed severe hyperhomocysteinemia and activation of the hepatic UPR.

50 ts and a relation was recently shown between hyperhomocysteinemia and Alzheimer disease.

51 regard to the 2 independent risk factors of hyperhomocysteinemia and arterial hypertension.

52 al failure, a condition associated with both hyperhomocysteinemia and atherosclerosis, treatment with

53 Other markers such as hyperhomocysteinemia and deficiencies of antithrombin, p

54 ulating methylation; the MCD+B diet worsened hyperhomocysteinemia and depressed liver methylation pot

55 Tg-I278T Cbs(-/-) mice exhibited severe hyperhomocysteinemia and endothelial dysfunction in cere

56 e Mthfr gene sensitizes mice to diet-induced hyperhomocysteinemia and endothelial dysfunction.

57 on to the fatty liver and no contribution to hyperhomocysteinemia and ER stress in intragastric alcoh

58 s containing ethanol or homocysteine induced hyperhomocysteinemia and glucose intolerance in control,

59 studies have revealed a correlation between hyperhomocysteinemia and hearing loss.

60 Using an atherogenic diet that produces both hyperhomocysteinemia and hypercholesterolemia, we tested

61 cal perturbations of methylmalonic acidemia, hyperhomocysteinemia and hypomethioninemia caused by the

62 Investigations have revealed severe hyperhomocysteinemia and hypomethioninemia, reduced fibr

63 Alcohol feeding induced modest hyperhomocysteinemia and increased homocysteine levels i

64 that expression of Tg-CBS rescued the severe hyperhomocysteinemia and neonatal lethality of Cbs delet

65 ociated with the degree of liver injury were hyperhomocysteinemia and strain-dependent differences in

66 literature regarding the association between hyperhomocysteinemia and TCAD.

67 /-) genotype sensitizes mice to diet-induced hyperhomocysteinemia and that hyperhomocysteinemia alter

68 hydrofolate reductase (MTHFR) predisposes to hyperhomocysteinemia and vascular disease.

69 An association between moderate hyperhomocysteinemia and vascular dysfunction was confir

70 objective was to determine the prevalence of hyperhomocysteinemia and vitamin B-12 deficiency in elde

71 generative diseases that are associated with hyperhomocysteinemia and, more recently, have implicated

72 Hypothyroidism may be a treatable cause of hyperhomocysteinemia, and elevated plasma homocysteine l

73 In vivo studies using CBS+/-, a model for hyperhomocysteinemia, and sibling CBS+/+ control mice re

74 steatosis, endoplasmic reticulum stress, and hyperhomocysteinemia, and this correlates with induction

75 )S increases progressively with the grade of hyperhomocysteinemia, and under conditions of severely e

76 hionine intake with B vitamin deficiency and hyperhomocysteinemia; and (iii) normal methionine intake

77 Hyperhomocysteinemia appears to be an independent risk f

78 Low cobalamin concentrations and mild hyperhomocysteinemia are common in the elderly but ethni

79 e cellular hypomethylation in the setting of hyperhomocysteinemia because of cystathionine beta-synth

80 hat supplementation with B vitamins prevents hyperhomocysteinemia but is not sufficient to prevent th

81 Mice exhibited a remarkable hyperhomocysteinemia but no increase was seen in rats.

82 alcoholic mouse liver and that correction of hyperhomocysteinemia by betaine or other approaches may

83 to tPA can be inhibited by homocysteine and hyperhomocysteinemia can be induced by L-methionine supp

84 Although moderate hyperhomocysteinemia can be treated effectively by admin

85 In many patients, hyperhomocysteinemia can be treated or prevented by diet

86 Because hyperhomocysteinemia can occur in cholesterol gallstone

87 abolism, combined methylmalonic acidemia and hyperhomocysteinemia, cblC type, is caused by mutations

88 Hyperhomocysteinemia confers a high risk for thrombotic

89 Hyperhomocysteinemia contributes to vascular dysfunction

90 form of combined methylmalonic acidemia and hyperhomocysteinemia, designated cblX.

91 Mice with moderate/severe hyperhomocysteinemia due to deficiency or absence of the

92 In humans, severe hyperhomocysteinemia due to genetic alterations in cysta

93 Hence, mild hyperhomocysteinemia due to reduced CBS expression impai

94 Hyperhomocysteinemia during pregnancy, which is a conseq

95 of mouse to up-regulate BHMT which prevents hyperhomocysteinemia, endoplasmic reticulum stress, and

96 We conclude that hyperhomocysteinemia enhances susceptibility to arterial

97 ), as was the prevalence of mild-to-moderate hyperhomocysteinemia (>12 microM; NHD, 57%; SHD, 94%; P

98 13.0 vs. 11.0+/-3.0 micromol/L, P<0.01), and hyperhomocysteinemia (>90th percentile for controls, 14.

99 Hyperhomocysteinemia has been associated with endoplasmi

100 Hyperhomocysteinemia has been commonly found among heart

101 Hyperhomocysteinemia has been correlated with hepatic st

102 Hyperhomocysteinemia has been proposed to inhibit the pr

103 Hyperhomocysteinemia has been recognized as an important

104 Hyperhomocysteinemia has been recognized as an independe

105 Although hyperhomocysteinemia has been recognized recently as a p

106 Alcohol-induced hyperhomocysteinemia has been reported in rats and human

107 ysfunction, and ERG defects; those with mild hyperhomocysteinemia have delayed retinal morphological/

108 that precipitate low blood folate levels and hyperhomocysteinemia have not been investigated previous

109 Animals with genetic hyperhomocysteinemia have so far not displayed atheromat

110 Many elderly subjects with hyperhomocysteinemia have undiagnosed vitamin B-12 defic

111 The association of moderate hyperhomocysteinemia (HHcy) (15-30 umol/L) with cardiova

112 ies in homocysteine (Hcy) metabolism lead to hyperhomocysteinemia (HHcy) and cause endothelial dysfun

113 tritional and genetic deficiencies, leads to hyperhomocysteinemia (HHcy) and endothelial dysfunction,

114 However, the joint effect of hyperhomocysteinemia (HHcy) and hyperglycemia (HG) on en

115 The relationship between hyperhomocysteinemia (HHcy) and obesity with low skeleta

116 ) were compared in patients with and without hyperhomocysteinemia (HHcy) and varying severity of HHcy

117 Hyperhomocysteinemia (HHcy) has been considered a vascul

118 Hyperhomocysteinemia (HHcy) impairs re-endothelializatio

119 Hyperhomocysteinemia (HHcy) increases permeability of th

120 Previously, we demonstrated that hyperhomocysteinemia (HHcy) induced T cell intracellular

121 Hyperhomocysteinemia (HHcy) is a reliable indicator of c

122 Although hyperhomocysteinemia (HHcy) is a well-known risk factor

123 Hyperhomocysteinemia (HHcy) is an independent risk facto

124 Hyperhomocysteinemia (HHcy) is associated with endotheli

125 Hyperhomocysteinemia (HHcy) is associated with several h

126 Hyperhomocysteinemia (HHcy) is prevalent in patients wit

127 Hyperhomocysteinemia (HHcy) is prevalent in patients wit

128 Diet-mediated induction of hyperhomocysteinemia (HHcy) recapitulates numerous featu

129 Using a Tg-I278T Cbs(-/-) mouse model of hyperhomocysteinemia (HHcy) which replicates the connect

130 We previously reported that hyperhomocysteinemia (HHcy), an independent risk factor

131 Vitamin B deficiencies, which can lead to hyperhomocysteinemia (Hhcy), are commonly reported in pa

132 with a B-vitamin deficient diet that induces hyperhomocysteinemia (HHcy), cerebral vessel disease, an

133 roduction and altered caveolin expression in hyperhomocysteinemia (HHcy), leading to endothelial dysf

134 either a control diet or a diet that induces hyperhomocysteinemia (HHcy).

135 nflammasome products from these cells during hyperhomocysteinemia (hHcy).

136 Hyperhomocysteinemia (hHcys) enhances ceramide productio

137 Hyperhomocysteinemia (hHcys) is considered an independen

138 ing in podocyte and glomerular injury during hyperhomocysteinemia (hHcys).

139 Hyperhomocysteinemia (hyperHcy) is an important risk fac

140 rs, including smoking, hypercholesterolemia, hyperhomocysteinemia, hypertension, and diabetes mellitu

141 therefore, support the hypothesis that acute hyperhomocysteinemia impairs microvascular dilation in t

142 We therefore conclude that hyperhomocysteinemia impairs postnatal angiogenesis by d

143 nce of folate and cobalamin deficiencies and hyperhomocysteinemia in Bangladesh.

144 rocess, has been shown to be associated with hyperhomocysteinemia in experimental and human studies.

145 his article is to evaluate the prevalence of hyperhomocysteinemia in heart transplant recipients but

146 Despite a very high prevalence of hyperhomocysteinemia in MHD patients, lower values of tH

147 Thus, hyperhomocysteinemia in mice was associated with hypertr

148 generation of APC by thrombin is impaired in hyperhomocysteinemia in monkeys and that hyperhomocystei

149 ose folic acid lowers but fails to normalize hyperhomocysteinemia in patients with predialysis chroni

150 Studies of the prevalence and mechanism of hyperhomocysteinemia in RA are warranted.

151 serum alanine aminotransferase increase, and hyperhomocysteinemia in rats than in mice.

152 The underlying cause of hyperhomocysteinemia in renal disease is not entirely un

153 entation may be necessary to prevent fasting hyperhomocysteinemia in such persons.

154 om low plasma PLP in most subgroups and from hyperhomocysteinemia in the elderly.

155 ients have a persistent excess prevalence of hyperhomocysteinemia in the era of fortification but rem

156 Despite a reduction in hyperhomocysteinemia in the folic acid group compared wi

157 d fortification program on the prevalence of hyperhomocysteinemia in the older population with coexis

158 in metabolism seem to be the major causes of hyperhomocysteinemia in this particular population.

159 FVa by APC are not impaired during moderate hyperhomocysteinemia in vivo.

160 l to study ANXII function and the effects of hyperhomocysteinemia in vivo.

161 rol and low-density lipoprotein cholesterol, hyperhomocysteinemia, increased lesional oxidative stres

162 A yeast model of hyperhomocysteinemia indicates a toxic effect, correlate

163 ysfunction, we investigated whether moderate hyperhomocysteinemia induced by an oral methionine load

164 he first time, that the relationship between hyperhomocysteinemia induced by folate deficiency and pr

165 Remarkably, hyperhomocysteinemia induced in wild-type and cystathion

166 Overexpression of DDAH1 protects from hyperhomocysteinemia-induced alterations in cerebral art

167 Hyperhomocysteinemia is a major and independent risk fac

168 Hyperhomocysteinemia is a potential risk factor for card

169 Hyperhomocysteinemia is a putative risk factor for cardi

170 Hcy damages cerebrovascular endothelium, and hyperhomocysteinemia is a risk factor for stroke.

171 Hyperhomocysteinemia is a risk factor for thrombosis, bu

172 Mild hyperhomocysteinemia is accepted as a risk factor for pr

173 ospective and case-control studies show that hyperhomocysteinemia is an independent risk factor for a

174 Hyperhomocysteinemia is an independent risk factor for c

175 Although hyperhomocysteinemia is an independent risk factor for c

176 Because hyperhomocysteinemia is an independent risk factor for c

177 Hyperhomocysteinemia is an independent risk factor for c

178 Hyperhomocysteinemia is an independent risk factor for c

179 These prospective observations confirm that hyperhomocysteinemia is an independent risk factor for c

180 Hyperhomocysteinemia is an independent risk factor for c

181 Considerable evidence suggests that hyperhomocysteinemia is an independent vascular risk fac

182 Hyperhomocysteinemia is associated with abnormal endothe

183 Correspondingly, inborn hyperhomocysteinemia is associated with an increased pre

184 Hyperhomocysteinemia is associated with increased risk f

185 Hyperhomocysteinemia is associated with increased risk o

186 Hyperhomocysteinemia is associated with inflammation and

187 These results suggest that isolated hyperhomocysteinemia is atherogenic and alters hepatic a

188 Hyperhomocysteinemia is caused by genetic and lifestyle

189 It has been suggested that hyperhomocysteinemia is caused by MTX and is responsible

190 Mild hyperhomocysteinemia is common among maintenance hemodia

191 Severe hyperhomocysteinemia is due to rare genetic defects resu

192 zed H2S-generating reactions to the grade of hyperhomocysteinemia is in stark contrast to the respons

193 Hyperhomocysteinemia is now recognized as a common risk

194 These studies indicate that although hyperhomocysteinemia is often associated with hepatic st

195 Hyperhomocysteinemia is often associated with liver and

196 from vascular complications whereas dietary hyperhomocysteinemia is often used to induce atheroscler

197 Mild to moderate hyperhomocysteinemia is prevalent in humans and is impli

198 Hyperhomocysteinemia is related to poor recall and this

199 , mildly elevated plasma total homocysteine (hyperhomocysteinemia) is associated with increased risk

200 Elevated plasma homocysteine (hyperhomocysteinemia) is associated with occlusive vascu

201 g level of homocysteine (Hcy), also known as hyperhomocysteinemia, is a risk factor for Alzheimer's d

202 bout it, and what the clinical impact of the hyperhomocysteinemia itself is.

203 Thus, we conclude that hyperhomocysteinemia leads to significant increases in t

204 e acknowledged left ventricular hypertrophy, hyperhomocysteinemia, lipoprotein(a) excess, hypertrigly

205 Post-methionine-load hyperhomocysteinemia may be due to heterozygous cystathi

206 These findings suggest that inflammation and hyperhomocysteinemia may be important mechanisms by whic

207 tor V and that the prothrombotic tendency in hyperhomocysteinemia may be related to impaired inactiva

208 y be increased in Alzheimer disease (AD) and hyperhomocysteinemia may contribute to disease pathophys

209 Excessive H(2)S production in hyperhomocysteinemia may contribute to the associated ca

210 in vivo and suggest that methionine-induced hyperhomocysteinemia may reverse hyperfibrinolysis in AP

211 The prevalence of hyperhomocysteinemia (men: >11.4 micromol/L; women: >10.

212 Despite hyperhomocysteinemia, no patients exhibited lens disloca

213 Relative to their RTR counterparts, the hyperhomocysteinemia of HD patients seems to be consider

214 th comparable baseline tHcy levels, the mild hyperhomocysteinemia of maintenance HD patients is much

215 The effect of hyperhomocysteinemia on H19 DMD methylation was tissue-s

216 We examined effects of hyperhomocysteinemia on structure and mechanics of cereb

217 rly in populations with folate deficiency or hyperhomocysteinemia or both, may lower blood arsenic co

218 uctase C677T genotype was not a predictor of hyperhomocysteinemia or CAC status.

219 Elevated blood levels of homocysteine (Hcy), hyperhomocysteinemia or homocystinuria, have been associ

220 16 microM) or in human volunteers with acute hyperhomocysteinemia (plasma tHcy, 45 +/- 6 microM).

221 In aorta, hyperhomocysteinemia produced an increase in H19 DMD met

222 The present study determined whether hyperhomocysteinemia produces decreased tissue methylati

223 in hyperhomocysteinemia in monkeys and that hyperhomocysteinemia produces resistance to APC in monke

224 We conclude that hyperhomocysteinemia produces tissue-specific changes in

225 Whereas diet-induced hyperhomocysteinemia promotes atherosclerosis in animal

226 These findings suggest that hyperhomocysteinemia promotes cerebral vascular hypertro

227 dies with human beings and animals with mild hyperhomocysteinemia provided encouraging results in the

228 emodialysis patients (ie, >90%) exhibit mild hyperhomocysteinemia refractory to treatment with either

229 The hyperhomocysteinemia regularly found in hemodialysis pat

230 Hyperhomocysteinemia resulted in a reduction in the MBF

231 In mouse models, dietary or genetic hyperhomocysteinemia results in liver or brain pathologi

232 In humans, severe genetic hyperhomocysteinemia results in premature death from vas

233 In mice, hyperhomocysteinemia secondary to a high-methionine diet

234 d 59-fold and 72-fold in human patients with hyperhomocysteinemia secondary to mutations in methylene

235 Mild hyperhomocysteinemia seen in fasting conditions is due t

236 -vitamin-deficient diet for 10 weeks induced hyperhomocysteinemia, significantly impaired spatial lea

237 ine beta-synthase knockout mice, a model for hyperhomocysteinemia, suggesting that one-carbon metabol

238 nse to protect from prothrombotic effects of hyperhomocysteinemia than CBS(-/-) humans.

239 e United Kingdom have a higher prevalence of hyperhomocysteinemia than do their European counterparts

240 1.8 micro mol/L, and 94% of the patients had hyperhomocysteinemia (tHcy >13.5 micro mol/L).

241 Although folic acid reduces hyperhomocysteinemia, the effect on adverse vascular eve

242 Hyperhomocysteinemia, the MTHFR C677T mutation, and fola

243 as an inhibitory mechanism in patients with hyperhomocysteinemia, the sensitivity of DDAH-1 to inhib

244 The odds ratio relating hyperhomocysteinemia to recall of > or =1 of 3 previousl

245 A MEDLINE search using the key words hyperhomocysteinemia, transplant coronary artery disease

246 tamin B(12), and vitamin B(6)) would prevent hyperhomocysteinemia, vascular dysfunction, and atherosc

247 hen methionine-rich diets are used to induce hyperhomocysteinemia, vascular pathology is often observ

248 Hyperhomocysteinemia was accompanied by higher levels of

249 In brain, hyperhomocysteinemia was accompanied by increased H19 DM

250 Hyperhomocysteinemia was defined as total serum homocyst

251 Hyperhomocysteinemia was defined as total serum homocyst

252 Hyperhomocysteinemia was found in 91.35% of HCV-infected

253 Hyperhomocysteinemia was induced by feeding mice alcohol

254 METHODS AND Hyperhomocysteinemia was induced in DDAH1 transgenic (DD

255 Hyperhomocysteinemia was more frequent in patients with

256 rposes of this study were to explore whether hyperhomocysteinemia was related to MTX administration a

257 nd the difference between extreme and severe hyperhomocysteinemia, we have examined two mouse models

258 e, hypertension, diabetes, dyslipidemia, and hyperhomocysteinemia were established as aggravating fac

259 e, hypertension, diabetes, dyslipidemia, and hyperhomocysteinemia were found significantly different

260 Low blood folate levels result in hyperhomocysteinemia, which has been associated with inc

261 Hyperhomocysteinemia, which is an independent risk facto

262 morphisms may play a role in the etiology of hyperhomocysteinemia, which is correlated with cardiovas

263 Bangladeshi men have a high prevalence of hyperhomocysteinemia, which is more closely associated w

264 Hyperhomocysteinemia, which is most strongly associated

265 volunteers or patients newly diagnosed with hyperhomocysteinemia with a C677T polymorphism of the MT

266 s enzyme are the leading cause of hereditary hyperhomocysteinemia with attendant cardiovascular and o

267 cular changes may mediate the association of hyperhomocysteinemia with human age-related cognitive de

268 d B vitamin-deficient diets developed severe hyperhomocysteinemia without any increase in vascular pa