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1       Mucoid isolates were more likely to be hypermutators.
2 eds the fitness advantage, selecting against hypermutators.
3 clear separation of function by becoming DNA hypermutators.
4 d of transient hypermutation, and that these hypermutators account for the mutations that appear.
5                                 Importantly, hypermutator alleles that accelerate AMR development did
6 in 28 progeny derived from a cross between a hypermutator and wild-type identified a locus associated
7 i-loss isolates were identified that are not hypermutators and have not accumulated transposons.
8      From these numbers we conclude that the hypermutators are responsible for nearly all multiple mu
9                                              Hypermutators arise through several mechanisms, includin
10 ronmental stresses may lead to selection for hypermutator bacterial cells, which have an increased ch
11  fluctuation analysis, and we identified two hypermutator C. neoformans clinical isolates with increa
12        Finally, a subpopulation of transient hypermutators could be a source of multiple variant alle
13                Previously, we identified two hypermutator Cryptococcus neoformans clinical isolates t
14  of the effect of spontaneous mutations in a hypermutator (DeltamutS) strain of the bacterium Pseudom
15 P levels and (ii) this increase mediates the hypermutator effect of Poldelta-R696W by facilitating th
16                                      Whether hypermutators generate resistance through predominantly
17        Whole-genome sequencing revealed both hypermutator genomes harbour a nonsense mutation in the
18  little evidence exists of stable eukaryotic hypermutators in nature.
19 tigate whether RNAi-loss isolates can become hypermutators, in vitro passaging was performed.
20               However, the long-term fate of hypermutators is unknown.
21 draft genome sequence of a derived inducible hypermutator isolate differed from those of general hype
22            Our study identifies a eukaryotic hypermutator lineage spread over two continents and sugg
23  driven by specific DNA repair defects using hypermutator lineages, and further deconvolute the spect
24 rted here investigated the contribution that hypermutators make to the mutations occurring in a Lac-
25 tions living in stable environments, whereas hypermutators may evolve if conditions change.
26                 The apparent ease with which hypermutators may switch to alternative resistance mecha
27 cur in 5-10% of sporadic CRCs and underlie a hypermutator, microsatellite-stable molecular phenotype.
28                        A dominant mucoid and hypermutator mutL lineage was replaced after 11 days by
29 eatment with alkylating agents resulted in a hypermutator phenotype at different rates across the gli
30 nt mutant subpopulations was associated with hypermutator phenotype but was not good enough to be use
31                                            A hypermutator phenotype in two cases with >8 times higher
32 ficient DNA mismatch repair (dMMR) induces a hypermutator phenotype that can lead to tumorigenesis; h
33 ia coli population that first evolved a mutT hypermutator phenotype was later invaded by two independ
34                   One outbreak isolate had a hypermutator phenotype with a higher number of SNPs than
35  including a mutation in mutS that confers a hypermutator phenotype.
36  high transposon burden, which resulted in a hypermutator phenotype.
37                                          The hypermutator-phenotype of dMMR tumours theoretically ena
38  gains are early genetic events and that the hypermutator-phenotype remains active during progression
39 point mutations, amplifications, fusions and hypermutator phenotypes, in addition to global gene expr
40 an isolate containing a high Cnl1 burden, F1 hypermutator progeny inheriting a high transposon burden
41                              The presence of hypermutator Pseudomonas aeruginosa was associated with
42 tator isolate differed from those of general hypermutators reported in the literature.
43             Mutational signature analysis of hypermutators shows stronger endogenous mutational proce
44                                 Furthermore, hypermutator states are transitory and repeatedly altern
45 ad among patients, with multiple examples of hypermutator strain emergence within patients and, as a
46                     The successful growth of hypermutator strains of bacteria contradicts a clear pre
47                          Furthermore, unlike hypermutator strains, the G233A variant conveys no measu
48 e transient and do not involve selection for hypermutator strains.
49  a degree that can rival clinically relevant hypermutator strains.
50 al, but phenotypically diverse population of hypermutator strains.
51 , such as Pseudomonas aeruginosa, can become hypermutators upon loss of DNA mismatch repair (MMR) and
52              Thus, the long-term fate of the hypermutators was governed by the selective advantage ar
53                                  Although no hypermutators were found in two C. neoformans RNAi-loss