ライフサイエンスコーパス: hyperosmolar

1 Many sexual lubricants are hyperosmolar.

2 lity further revealed lymphoid tissues to be hyperosmolar.

3 Because acetic acid is hyperosmolar, a second aim was to determine if the osmol

4 er, current treatment options are limited to hyperosmolar agents and surgical decompression, therapie

5 Hyperosmolar agents are cornerstone therapies for pediat

6 Its Ras association (RA) domain acts in both hyperosmolar and filamentous growth pathways, but its co

7 We apply these results to the hyperosmolar and pheromone mitogen-activated protein (MA

8 ylene glycol accumulation, as reflected by a hyperosmolar anion gap metabolic acidosis, was observed

9 lymerizing agent latrunculin B abrogated the hyperosmolar barrier enhancement as well as the actin fi

10 We examined the effect of hyperosmolar BBB disruption on brain permeability of thr

11 hese findings indicate that in EC exposed to hyperosmolar challenge, the involvement of focal adhesio

12 After a hyperosmolar challenge, there was markedly reduced expre

13 ministered directly into the renal artery in hyperosmolar citrate solution (3 mug/ml) with the renal

14 pound120 per liter) and Marshall's Solution (hyperosmolar citrate, pound10 per liter).

15 10-min warm ischemia and flushed with 500 mL hyperosmolar citrate.

16 sttransplant diabetes included ketoacidosis, hyperosmolar coma or precoma, and sensorimotor periphera

17 ed (3.5-fold) when the cells were exposed to hyperosmolar conditions (DMEM-F12 culture medium plus 50

18 s to provide indirect evidence of short-term hyperosmolar conditions during tear instability and to t

19 n-Hep complexes, which was inhibited >70% by hyperosmolar conditions, confirming that uptake is media

20 r protein Shc in lysates of RLMEC exposed to hyperosmolar conditions.

21 neuronal survival is not enhanced by chronic hyperosmolar conditions.

22 ent growth and resist PCD due to hypoxia and hyperosmolar conditions.

23 etT3 was the major choline transporter under hyperosmolar conditions.

24 ein levels increased in RPE cells exposed to hyperosmolar conditions.

25 ns and increased by approximately twofold in hyperosmolar conditions.

26 nse to growth factors, oxidative stress, and hyperosmolar conditions.

27 transiently stressed with the same range of hyperosmolar culture medium, and proinflammatory mitogen

28 of ultrasound-guided Achilles intratendinous hyperosmolar dextrose prolotherapy and introduce a novel

29 sham, 2) HS + CR, and 3) HS + CR + PR with a hyperosmolar dextrose-based solution (Delflex 2.5%).

30 e data suggest that the clinical efficacy of hyperosmolar disruption therapy in conjunction with chem

31 Survival after transplantation using hyperosmolar donors was not affected in this study.

32 tions after instillation of NaCl and sucrose hyperosmolar drops (300-1000 mOsM/kg).

33 Hyperosmolar electrolyte penetration allowed non-invasiv

34 Resistance changes due to apically applied hyperosmolar electrolyte were used to identify barrier d

35 Hyperosmolar enemas induce epithelial damage, and enema

36 vation of cell viability and function in the hyperosmolar environment of the renal medulla is a compl

37 Hyperosmolar exposure also increased activity of focal a

38 The dominant effect of a 15-min hyperosmolar exposure was an increase in the trans-endot

39 Barrier recovery after a 1-min hyperosmolar exposure was delayed > 25 min.

40 tive isoforms of Rac1, the actin response to hyperosmolar exposure was enhanced or blocked, respectiv

41 One eye was randomized to hyperosmolar eye drops (treatment); the fellow eye was r

42 patible with a clinically relevant effect of hyperosmolar eye drops and do not support their routine

43 ling (EDEMAS) trial assessed the efficacy of hyperosmolar eye drops on corneal edema resolution.

44 indicating no clinically relevant effect of hyperosmolar eye drops on early morning corneal edema.

45 morning stromal edema was not accelerated by hyperosmolar eye drops, which more frequently caused AEs

46 n flux reversal from isosmolar absorption to hyperosmolar filtration (P < 0.01), and by hyperosmolari

47 specific treatments (e.g., administration of hyperosmolar fluids and the use of hyperventilation) in

48 y measured through 12 h was reduced with the hyperosmolar gel (P=.037).

49 e anus occurred to a greater degree with the hyperosmolar gel than with the iso-osmolar formulation (

50 The hyperosmolar gel was also associated with lower isotope

51 Rectally applied hyperosmolar gels induce greater epithelial denudation a

52 ibly increases the risk of HIV transmission, hyperosmolar gels make poor rectal microbicide formulati

53 ide formulation, we evaluated the effects of hyperosmolar gels on the rectal mucosa.

54 odissection and subsequent prolotherapy with hyperosmolar glucose solution is safe, effective, inexpe

55 ne green uptake was markedly impaired in the hyperosmolar group, suggesting that hepatocyte and not s

56 nsulin therapy for diabetic ketoacidosis and hyperosmolar hyperglycemic state resulted in improvement

57 a in patients with diabetic ketoacidosis and hyperosmolar hyperglycemic state.

58 setting to manage diabetic ketoacidosis and hyperosmolar hyperglycemic state.

59 lycemia and none of diabetic ketoacidosis or hyperosmolar hyperglycemic syndrome.

60 infusing small, non-adhesive NP via CED in a hyperosmolar infusate solution.

61 Furthermore, hyperosmolar infusion blocked TNF-alpha-induced P-select

62 illary immunofluorescence indicated that the hyperosmolar infusion markedly augmented actin filament

63 ial cells freshly harvested from lungs given hyperosmolar infusions indicated a genistein-inhibitable

64 larity and tear instability, suggesting that hyperosmolar levels in the tear film may transiently spi

65 These findings indicate that hyperosmolar lubricants alter VEC morphology and are sel

66 We sought to investigate if hyperosmolar lubricants are toxic to the vaginal mucosal

67 r release were analyzed after challenge with hyperosmolar mannitol (850 mOsm).

68 Intracarotid arterial hyperosmolar mannitol (ICAHM) blood-brain barrier disrup

69 barrier has been disrupted by exposure to a hyperosmolar mannitol solution, permitting the translumi

70 ld be enhanced by intrathecal co-infusion of hyperosmolar mannitol.

71 t brain after intracarotid administration of hyperosmolar mannitol.

72 Indeed, reducing surface tension with hyperosmolar media promoted microridge formation.

73 auT reporter activity in isotonic as well as hyperosmolar media.

74 and peaked at 60 minutes in cells exposed to hyperosmolar media.

75 A and protein levels in the cells exposed to hyperosmolar media.

76 Exposure of PCHCE cells to hyperosmolar medium increased TG activity at 3 hours, le

77 the wild-type and the phgA mutant strains in hyperosmolar medium, and when analyzed by electron micro

78 ptake occurred after 17 hours of exposure to hyperosmolar medium.

79 eath-inducing paradigms: mitogen withdrawal, hyperosmolar metabolic stress, and treatment with etopos

80 ricants were compounded into iso-osmolar and hyperosmolar mixtures (283 and 3429 mOsm/kg, respectivel

81 , 30 responded to intraduodenal perfusion of hyperosmolar NaCl (500 mosmol l(-1)), 27 responded to ta

82 to intraduodenal administration of maltose, hyperosmolar NaCl, and light mucosal stroking were exami

83 pancreatic secretion induced by maltose and hyperosmolar NaCl.

84 related adverse event due to hyperglycaemic, hyperosmolar, non-ketotic syndrome.

85 Patients with diabetic ketoacidosis or hyperosmolar nonketotic coma were excluded.

86 tract, and by inference the development of a hyperosmolar periciliary fluid, do not appear to be the

87 Hyperosmolar PR during CR maintains intestinal blood flo

88 Hyperosmolar pretreatment also blocked the acid-induced

89 microscopy of liver biopsies collected from hyperosmolar rats demonstrated profound ultrastructural

90 Cold-preserved livers from hyperosmolar rats were observed to have elevated hepatic

91 n the lung, salivary, and lacrimal glands of hyperosmolar rats, suggesting potential physiologic rele

92 n cells in kidney and brain are exposed to a hyperosmolar salt condition (hypertonicity) due to the o

93 ke poor rectal microbicide formulations, and hyperosmolar sexual lubricants may increase susceptibili

94 muscle contraction, and sorbitol (producing hyperosmolar shock) did not increase AMPK alpha2 activit

95 stigated: co-infusion of nanoparticles and a hyperosmolar solution of mannitol, and pre-infusion of a

96 -51 degrees C), menthol (10-100 microM), and hyperosmolar solutions (NaCl, sucrose; 297-3014 mOsm), a

97 These sensations also occurred with hyperosmolar solutions (thresholds, 450-460 mOsM/kg) tha

98 Clinically, infusion of hyperosmolar solutions is used to enhance chemotherapeut

99 This is thought to be a direct effect of hyperosmolar solutions on the visceral microvessels.

100 us (progesterone) and a pathological stress (hyperosmolar sorbitol) in Xenopus laevis oocytes, a cell

101 ncreased more than twofold after exposure to hyperosmolar sorbitol.

102 diabetic ketoacidosis (DKA) or hyperglycemic hyperosmolar state (HHS).

103 iabetic ketoacidosis [DKA] and hyperglycemic hyperosmolar state [HHS]) are life-threatening acute com

104 plications for epithelial tissues subject to hyperosmolar stress and other mitochondrial diseases.

105 of hypotonic stress is distinct from that of hyperosmolar stress in mammalian cells.

106 FBP-3 expression is decreased in response to hyperosmolar stress in vitro and in an animal model of D

107 Here we show that hyperosmolar stress induces mitophagy through differenti

108 Hyperosmolar stress is not a necessary determinant of AR

109 (iPSC) derived neurons under inflammatory or hyperosmolar stress, they may affect tau aggregate propa

110 DED, we next sought to determine whether the hyperosmolar stress-mediated decrease in IGFBP-3 alters

111 drial dysfunction occurs as a consequence of hyperosmolar stress.

112 the corneal epithelium responds to transient hyperosmolar stress.

113 PK was activated at 600 mOsM/kg of transient hyperosmolar stress.

114 mperature or in the presence of cell wall or hyperosmolar stresses.

115 However, a 15-min intravenous infusion of hyperosmolar sucrose given up to 1 h before or 30 min af

116 ble strategy, we gave 15-minute infusions of hyperosmolar sucrose in lung venular capillaries imaged

117 The potential applicability of hyperosmolar sucrose in therapy for ALI requires conside

118 he extent to which intravascular infusion of hyperosmolar sucrose might protect against acid-induced

119 We infused hyperosmolar sucrose via the femoral vein.

120 ungs indicated that the protective effect of hyperosmolar sucrose was leukocyte independent.

121 howed that a brief intravascular infusion of hyperosmolar sucrose, given concurrently with airway aci

122 of the corneal epithelium in response to the hyperosmolar tear film in dry eye disease.

123 arameters describing water movement into the hyperosmolar tear film in vivo--were determined by a dye

124 trinsic factors that promote an unstable and hyperosmolar tear film.

125 oration of tears from the ocular surface and hyperosmolar tears.

126 Using isosmolar and hyperosmolar test solutions (colloid osmotic pressure =

127 pv4-/- mice drank less water and became more hyperosmolar than did wild-type littermates, a finding t

128 To consider hyperosmolar therapy as a possible strategy, we gave 15-

129 excluded; 787 children received some form of hyperosmolar therapy during the ICP-directed phase of ca

130 ive and prospective studies assessing use of hyperosmolar therapy in pediatric patients with severe t

131 Hyperosmolar therapy is often used to treat severe traum

132 Hyperosmolar therapy may be beneficial in lung inflammat

133 In this study, we report that hyperosmolar treatment mediates FAK dephosphorylation an

134 duced bronchoconstriction (EIB) is caused by hyperosmolar triggering of mast cells.