ライフサイエンスコーパス: hyperphosphorylated

1 ogical state of tau is often referred to as "hyperphosphorylated".

2 DNA replication stress, RPA2 is extensively hyperphosphorylated.

3 loss of NCC function, whereas NKCC2 becomes hyperphosphorylated.

4 initiation factor 2B [eIF2Bepsilon(S536)] is hyperphosphorylated.

5 g, which alleviates Fpk1 inhibition, Akl1 is hyperphosphorylated.

6 Hyperphosphorylated 4E-BP dissociates from eIF4E, allowi

7 t renal biopsies and PKD1-/- cells exhibited hyperphosphorylated 4E-BP1, a biomarker of increased tra

8 nterestingly, overexpressed and subsequently hyperphosphorylated 4EBP1.

9 Lesions containing hyperphosphorylated aggregated TDP-43 characterize amyot

10 acterized by the progressive accumulation of hyperphosphorylated, aggregated forms of tau.

11 The scFvs significantly reduced levels of hyperphosphorylated, aggregated tau in brain tissue of P

12 The antibodies markedly reduced hyperphosphorylated, aggregated, and insoluble tau.

13 ha-Syn) is a key protein that accumulates as hyperphosphorylated aggregates in pathologic hallmark fe

14 inantly nuclear to form detergent-resistant, hyperphosphorylated aggregates in the cytoplasm of affec

15 icrotubule-associated protein (MAP), becomes hyperphosphorylated, aggregates, and accumulates in the

16 expression with concomitant accumulation of hyperphosphorylated and abnormally folded proteinase K r

17 kinase Kns1 is differentially expressed and hyperphosphorylated and accumulates in the nucleus after

18 Neuronal inclusions of hyperphosphorylated and aggregated tau protein are a pat

19 The pathological accumulation of abnormally hyperphosphorylated and aggregated tau, a neuronal micro

20 eatures of AD, including amyloid deposition, hyperphosphorylated and aggregated tau, behavioral chang

21 NS5A is a phosphoprotein that exists in hyperphosphorylated and basally phosphorylated forms.

22 peptide (Abeta) within the brain along with hyperphosphorylated and cleaved forms of the microtubule

23 hroughout the brain as indicated by abnormal hyperphosphorylated and conformation-specific tau, which

24 mma 142V transgenic mice, the renal ETBR was hyperphosphorylated and ETBR-mediated natriuresis and di

25 and postmitotic hPSC-cardiomyocytes, RB1 is hyperphosphorylated and inactivated.

26 Because hyperphosphorylated and insoluble Tau are hallmarks in n

27 In AD, tau becomes hyperphosphorylated and misfolded at both presynaptic an

28 Neurofibrillary tangles (NFTs) composed of hyperphosphorylated and misfolded tau protein are a path

29 tubule-associated protein tau, which becomes hyperphosphorylated and pathologically aggregates in a n

30 togen-activated protein kinases (MAPKs) were hyperphosphorylated and the kinase Akt and its downstrea

31 ntitative proteomics identified sequences of hyperphosphorylated and three-repeat tau in transgenic m

32 C-terminal fragment led to the formation of hyperphosphorylated and ubiquitinated inclusions in moto

33 Cytoplasmic inclusions containing hyperphosphorylated and ubiquitinated TDP-43 are a patho

34 Synaptic tau seems to be hyperphosphorylated and ubiquitinated, and forms stable

35 f cTnI (cardiac troponin I) is significantly hyperphosphorylated, and in vitro studies suggest that i

36 fically associates with a fraction of RNAPII hyperphosphorylated at Ser5 and Ser7, which is a hallmar

37 In contrast, PPARgamma in PP5-KO cells was hyperphosphorylated at serine 112 but had reduced rosigl

38 showed that the C-terminal domain of RNAP is hyperphosphorylated at serine 5 (S5(P)) on VZV genes 9,

39 Interestingly, the T78S mutant was hyperphosphorylated at the Ser78 site relative to Thr78

40 At the onset of diabetes, tau was hyperphosphorylated at the tau-1, AT8, CP13, pS262, and

41 ed kinase 1A (DYRK1A) was one of the kinases hyperphosphorylated at Tyr-321 in all HNSCC cell lines.

42 In the absence of ANXA2, VEC is hyperphosphorylated at tyrosine 731 in response to vascu

43 Herein, we show that halpha-Syn forms hyperphosphorylated (at S129) and ubiquitin-positive LB-

44 gation only when large (>10 mer) aggregated, hyperphosphorylated (AT8- and AT100-positive) and nitrat

45 es of BAF's antiviral activity revealed that hyperphosphorylated BAF is unable to suppress viral DNA

46 state in the SE-Brg1 mutant, suggesting that hyperphosphorylated Brg1 cannot remodel chromatin.

47 s, ARF promoted the chromatin association of hyperphosphorylated, but not basal phosphorylated, topo

48 rs through its N-terminal WW domains and the hyperphosphorylated C-terminal domain (CTD) of RNA polym

49 We also find that the hyperphosphorylated C-terminal domain is preferentially

50 e in hypophosphorylated cdc24 mutants, while hyperphosphorylated cdc24 mutants that were resistant to

51 Hyperphosphorylated coat subunits accumulate in the sit4

52 It is hypothesized that the hyperphosphorylated, conformationally altered, and multi

53 the tandem FF repeat that interacts with the hyperphosphorylated CTD (PCTD).

54 al S83 site, resulting in a mitosis-specific hyperphosphorylated delta isoform.

55 pho-specific antibody, we show that PELP1 is hyperphosphorylated during cell cycle progression.

56 with PKC activity upregulates the level of a hyperphosphorylated form of CREB (hyper-PO4 CREB) and tr

57 This site is a component of the hyperphosphorylated form of NS5A, which is in good agree

58 hough methylation at R1810 is present on the hyperphosphorylated form of RNAPII in vivo, Ser2 or Ser5

59 report that Yra1 directly binds in vitro the hyperphosphorylated form of the CTD characteristic of el

60 bed around the pSer202/pThr205 region of the hyperphosphorylated form of the neuronal protein tau.

61 conversion of CasL into its serine/threonine hyperphosphorylated form, which is important for lymphoc

62 biquitination of IRS1 N-terminal fragment in hyperphosphorylated form, which was isolated from infect

63 CRL7) mediates the ubiquitination of IRS1 in hyperphosphorylated form.

64 In the disease Tau aggregates and becomes hyperphosphorylated forming paired helical and straight

65 iseases characterized by the accumulation of hyperphosphorylated forms of the microtubule-associated

66 and virion assembly, and exists in hypo- and hyperphosphorylated forms.

67 usion bodies formed by polyubiquitinated and hyperphosphorylated full-length and truncated TDP-43.

68 In NFI-hyperphosphorylated GBM cells, NFIB expression decreased

69 accumulation of insoluble, poorly branched, hyperphosphorylated glycogen in brain, muscle, heart, an

70 g the glycogen phosphatase laforin result in hyperphosphorylated glycogen that forms water-insoluble

71 d by the intracellular buildup of insoluble, hyperphosphorylated glycogen-like particles, called Lafo

72 d mice with either gene disrupted accumulate hyperphosphorylated glycogen.

73 lled ribosomes and activated to synthesize a hyperphosphorylated guanosine analogue, (p)ppGpp, which

74 Small modified nucleotides such as the hyperphosphorylated guanosine molecules ppGpp and pppGpp

75 Bacterial Rel proteins synthesize hyperphosphorylated guanosine nucleotides, denoted as (p

76 in vitro data confirmed that PINCH binds to hyperphosphorylated (hp) Tau and to E3 ubiquitin ligase,

77 provide the direct evidence that NF-M/H are hyperphosphorylated in AD compared with control brain an

78 We found that S6K was hyperphosphorylated in ANDV-infected, hypoxia-treated ME

79 HDAC2 was also hyperphosphorylated in cells infected with PRV lacking U

80 omain-containing inositol 5 phosphatase were hyperphosphorylated in GC cells and remained colocalized

81 e similar between groups; however, titin was hyperphosphorylated in HFpEF and correlated with betaLA.

82 n is supported by our finding that SAMHD1 is hyperphosphorylated in monocytoid THP-1 cells under nonr

83 In this study, we discovered that BRD4 is hyperphosphorylated in NUT midline carcinoma and identif

84 We found that STAT1 was hyperphosphorylated in response to cytokine stimulation

85 translocase FANCM, which we have shown to be hyperphosphorylated in response to various genotoxic age

86 ospholamban, and Ser23/24 in troponin-I were hyperphosphorylated in SA mice, whereas phosphorylation

87 Cdc2 expression is increased and Ubc9 is hyperphosphorylated in several cancers, and this represe

88 P70S6K was hyperphosphorylated in Tg1 somatosensory cortex, suggest

89 We also found that SK2 is hyperphosphorylated in the brain samples from a model of

90 Our data indicate that cTnI is hyperphosphorylated in the failing SHR myocardium compar

91 low copper and becomes more phosphorylated ("hyperphosphorylated") in elevated copper.

92 sion, resultant TTP protein builds up in the hyperphosphorylated inactive form.

93 most of the E4BP1 in the infected cell in a hyperphosphorylated, inactive state.

94 aggregation, forming detergent-resistant and hyperphosphorylated inclusions.

95 m target, acetyl-CoA carboxylase (ACC), were hyperphosphorylated, indicative of AMPK activation and A

96 athway leading from soluble and monomeric to hyperphosphorylated, insoluble and filamentous tau prote

97 tion is an obligatory consequence of mutated/hyperphosphorylated JAK2.

98 aiA can bind stably to complexes of KaiB and hyperphosphorylated KaiC.

99 Ten hyperphosphorylated KSP sites have been identified on th

100 diomyocytes, Ca(v)1.2 and phospholamban were hyperphosphorylated, leading to increased Ca(2+) spark o

101 e host restriction factor SAMHD1 exists in a hyperphosphorylated, less active state in male-derived m

102 Hyperphosphorylated lipin-1 remains sequestered in the c

103 lex with a Cdk regulatory subunit (Cks) to a hyperphosphorylated loop of Apc3.

104 tent evidence of accelerated accumulation of hyperphosphorylated microtubule associated protein tau i

105 Aggregates of the hyperphosphorylated microtubule-associated protein tau (

106 lar neuronal tangles consisting primarily of hyperphosphorylated microtubule-associated protein tau (

107 The hyperphosphorylated microtubule-associated protein tau i

108 ted with neurofibrillary tangles composed of hyperphosphorylated microtubule-associated protein, tau.

109 id beta peptide and intraneuronal tangles of hyperphosphorylated microtubule-associated tau protein (

110 ndependent of RSLD phosphorylation, though a hyperphosphorylated mimetic mutant failed to bind TNPO3

111 or ubiquitin, amyloid precursor protein, and hyperphosphorylated neurofilament proteins.

112 , which interact with hypophosphorylated and hyperphosphorylated NSP5, respectively, indicating that

113 viroplasm assembly and its association with hyperphosphorylated NSP5.

114 ed microtubules, while vNSP2 associates with hyperphosphorylated NSP5.

115 In Fmr1 KO neurons, Mdm2 is hyperphosphorylated, nuclear localized basally, and unaf

116 Analysis of the hyperphosphorylated Nup species revealed only phosphoser

117 in of the paused polymerase large subunit is hyperphosphorylated on serine 5, and phosphorylation of

118 Moreover, htau became progressively hyperphosphorylated over 2 months in vitro beginning wit

119 Tau protein is found to be aggregated and hyperphosphorylated (p-tau) in many neurologic disorders

120 beginning with nonsymptomatic neurons, while hyperphosphorylated P301S-htau-positive neurons from 5-m

121 llular diffuse and fibrillar Abeta deposits, hyperphosphorylated/pathologically conformed Tau, and pr

122 may result from proteasome overload because hyperphosphorylated Pin4C aggregation is associated with

123 ry to the central nucleoplasm and to foci of hyperphosphorylated Pol II "transcription factories" (TF

124 ivation in T-ALL and other cancers driven by hyperphosphorylated PP2A substrates has therapeutic pote

125 Cortactin was originally identified as a hyperphosphorylated protein in v-Src-transformed cells,

126 EGFR-driven resistance are characterized by hyperphosphorylated protein kinase AKT, a biomarker we v

127 ly unrecognized tumor suppressor function of hyperphosphorylated RB in suppressing NF-kappaB activity

128 tep in promoting cell cycle progression, and hyperphosphorylated Rb is commonly found in tumors.

129 Hyperphosphorylated RB releases E2F transcription factor

130 regulated cell cycle proteins, cyclin D1 and hyperphosphorylated Rb.

131 RyR2s are oxidized, nitrosylated, and PKA hyperphosphorylated, resulting in "leaky" channels in fa

132 lly, BaP treatment increased accumulation of hyperphosphorylated retinoblastoma protein (pRb) which c

133 RDGC, which dephosphorylates Rh1, results in hyperphosphorylated Rh1.

134 hromosomes is virtually identical to that of hyperphosphorylated RNA polymerase II (RNAPII), but is d

135 , Nanos1-depleted PGCs prematurely exhibit a hyperphosphorylated RNA polymerase II C-terminal domain

136 ulation of S-phase cells with high levels of hyperphosphorylated RPA-loaded single-stranded DNA.

137 n was also detected on chromatin-associated, hyperphosphorylated Rpb1, consistent with a role in tran

138 Enhanced SR Ca(2+) leak through CaMKII-hyperphosphorylated RyR2, in combination with larger I(N

139 Hyperactive, hyperphosphorylated RyRs because of reduced local phosph

140 Ryanodine receptor was protein kinase A-hyperphosphorylated, S-nitrosylated, oxidized, and deple

141 ositol pyrophosphates constitute a family of hyperphosphorylated signaling molecules involved in the

142 The two mAbs significantly reduced hyperphosphorylated soluble Tau in long term brain slice

143 ; (iii) strong and selective accumulation of hyperphosphorylated soluble tau multimers into the synap

144 related oligomeric amyloid-beta assemblies, hyperphosphorylated soluble tau species localized in syn

145 king patient-to-patient heterogeneity in the hyperphosphorylated species of soluble, oligomeric, seed

146 hat S222 phosphorylation predominates in the hyperphosphorylated species.

147 d, referred to as basally phosphorylated and hyperphosphorylated species.

148 Here, we show that ATR is transformed into a hyperphosphorylated state after DNA damage, and that a s

149 nt-rich conditions, Atg13 is maintained in a hyperphosphorylated state by the TORC1 kinase.

150 y, we found that PALB2 is transformed into a hyperphosphorylated state in response to ionizing radiat

151 mmediately after blood feeding, 4E-BP became hyperphosphorylated, suggesting rapid inhibition of its

152 ant intraneuronal pathological inclusions of hyperphosphorylated T40PL-GFP.

153 Detergent-resistant, ubiquitinated and hyperphosphorylated Tar DNA binding protein 43 (TDP-43,

154 Aggregated filamentous forms of hyperphosphorylated tau (a microtubule-associated protei

155 ase, the grafted tissue was characterized by hyperphosphorylated tau (AT8; immunofluorescent staining

156 Amyloid-beta (Abeta) and hyperphosphorylated tau (p-tau) aggregates form the two

157 rease in beta-amyloid Abeta(42/40) ratio and hyperphosphorylated tau (p-tau) species.

158 Here we report the use of recombinant hyperphosphorylated tau (p-tau) to identify potential ta

159 Remarkably, hyperphosphorylated tau (p-tau) was induced in alpha-syn

160 accumulation of cleaved caspase-3 (CC3) and hyperphosphorylated tau (PHF1) (a marker for neurodegene

161 th harmonized CSF assays of amyloid-beta and hyperphosphorylated tau (pTau), and longitudinal structu

162 gyrus using antibodies to synaptic vesicles, hyperphosphorylated tau (pTau), neurofibrillary tangle c

163 e, the grafted tissue showed the presence of hyperphosphorylated tau [both AT8 (phospho-tau Ser202 an

164 is an ordered and predictable progression of hyperphosphorylated tau abnormalities through the nervou

165 human diseases such as HIV transmission and hyperphosphorylated tau accumulation in Alzheimer's dise

166 t is defined by the presence of perivascular hyperphosphorylated tau aggregates in cortical tissue (M

167 tau pathology by looking for the presence of hyperphosphorylated tau aggregates, co-localization of t

168 changes in the 3R:4R isoform ratio and AT100-hyperphosphorylated tau aggregates, while P301L neurons

169 , neuroinflammation, increased production of hyperphosphorylated tau and amyloidogenic Abeta-peptides

170 The present quantitative study of hyperphosphorylated tau and beta amyloid in drug user br

171 yloid precursor protein and toxic effects of hyperphosphorylated tau and beta-amyloid probably contri

172 se in brain amyloid beta protein aggregates, hyperphosphorylated tau and microglia load as observed b

173 and brain mitochondrial function and reduced hyperphosphorylated Tau and necroptosis in HFD-fed rats.

174 hyperactivity and perikaryal aggregations of hyperphosphorylated Tau and neurofilaments, pathogenic h

175 -mediated neuropathological changes, such as hyperphosphorylated tau and neuronal death.

176 nied by a significant reduction in levels of hyperphosphorylated tau and oligomeric Abeta, the precur

177 early stages of AD prior to accumulation of hyperphosphorylated tau and suggested that increased CSF

178 sts SRPK2 may contribute to the formation of hyperphosphorylated tau and the pathogenesis of AD.

179 Filamentous inclusions made of hyperphosphorylated tau are characteristic of numerous h

180 ic plaques and intracellular accumulation of hyperphosphorylated tau as neurofibrillary tangles remai

181 NFTs contain aberrantly hyperphosphorylated Tau as paired helical filaments (PHF

182 lly characterized by perivascular tangles of hyperphosphorylated tau at the depth of sulci to later w

183 g that mice overexpressing CRF had increased hyperphosphorylated tau compared with wild-type litterma

184 Hyperphosphorylated tau deposition and neural tangle-lik

185 rotein cleaving enzyme 1, and both total and hyperphosphorylated tau expression, correlated with impa

186 ynaptotoxic role in Alzheimer's disease, and hyperphosphorylated tau facilitates Abeta toxicity.

187 Neurofibrillary tangles, composed of hyperphosphorylated tau fibrils, are a pathological hall

188 maze (RAWM) test and decreased the level of hyperphosphorylated tau immunostained with AT8 and PHF-1

189 n mitochondrial dysfunction and assesses how hyperphosphorylated tau impairs axonal transport of orga

190 inked to neurofibrillary tangles composed of hyperphosphorylated tau in AD.

191 where they interact and are associated with hyperphosphorylated Tau in Alzheimer disease brain.

192 erized by abundant filamentous inclusions of hyperphosphorylated tau in both neurons and glia.

193 Histological analysis demonstrated hyperphosphorylated tau in brainstem nuclei, directly or

194 We have shown previously that deposits of hyperphosphorylated tau in drug user brains exceed those

195 The levels of hyperphosphorylated tau in drug users fell far short of

196 the apoE4-driven accumulation of Abeta42 and hyperphosphorylated tau in hippocampal neurons, as well

197 no correlation between high beta amyloid and hyperphosphorylated tau in individual cases.

198 The accumulation of hyperphosphorylated tau in neurofibrillary tangles (NFTs

199 n of amyloid-beta in plaques, aggregation of hyperphosphorylated tau in neurofibrillary tangles and n

200 s and contribute to aberrant accumulation of hyperphosphorylated tau in neuronal cells affected by ta

201 titive low-level blasts accumulated abnormal hyperphosphorylated tau in neuronal perikarya and periva

202 c studies revealed a significant increase of hyperphosphorylated tau in synaptosomes of demented dogs

203 Aggregation of hyperphosphorylated tau in the brain correlates with the

204 Accumulation of hyperphosphorylated tau in the entorhinal cortex (EC) is

205 sis and markedly reduced levels of total and hyperphosphorylated TAU in the spinal cord, brain stem,

206 By localizing and quantifying hyperphosphorylated tau in vivo, results of tau PET imag

207 urodegenerative tauopathies characterized by hyperphosphorylated tau include frontotemporal dementia

208 aracterized pathologically by aggregation of hyperphosphorylated tau into neurofibrillary tangles (NF

209 Neurofibrillary pathology of abnormally hyperphosphorylated Tau is a key lesion of Alzheimer dis

210 Aggregation of hyperphosphorylated tau is a major hallmark of many neur

211 Hyperphosphorylated tau levels correlated significantly

212 owed neuronal loss and extensive deposits of hyperphosphorylated tau mainly involving the tegmentum o

213 However, the addition of a hyperphosphorylated tau mimic 352PHPtau significantly in

214 protein (T40PL-GFP Tg mouse line) exhibited hyperphosphorylated tau mislocalized to the somatodentri

215 The accumulation of hyperphosphorylated tau oligomers at human AD synapses i

216 Our findings suggest that synaptic hyperphosphorylated tau oligomers may be an important me

217 tauopathy by means of reducing the levels of hyperphosphorylated tau oligomers.

218 r topographical distribution and severity of hyperphosphorylated tau pathologic findings measured by

219 myloid beta 40 (Abeta(40))/Abeta(42) and tau/hyperphosphorylated tau pathologies and a coordinated re

220 Thirty-one of 33 cases (94%) showed hyperphosphorylated tau pathology in the form of neuropi

221 We hypothesized that hyperphosphorylated tau pathology is associated with cog

222 ic traumatic encephalopathy, the spectrum of hyperphosphorylated tau pathology ranged in severity fro

223 Hyperphosphorylated tau positive (AT8, AT100) neuropil t

224 Hyperphosphorylated tau positive neuropil threads increa

225 the RCAN1-1L protein exhibit accumulation of hyperphosphorylated tau protein (AT8 antibody), an early

226 function due to the regional accumulation of hyperphosphorylated tau protein (p-tau).

227 gp120-transgenic mice, we found evidence for hyperphosphorylated tau protein (paired helical filament

228 characterized by intraneuronal inclusions of hyperphosphorylated tau protein and abnormal expression

229 o effectively blocks accumulation of soluble hyperphosphorylated TAU protein and slows down the disea

230 rs suggests that repetitive brain trauma and hyperphosphorylated tau protein deposition promote the a

231 lical filaments (PHF), which are composed of hyperphosphorylated Tau protein dissociating from microt

232 f PET radiotracers for imaging aggregates of hyperphosphorylated tau protein in neurofibrillary tangl

233 CTE is defined by an abundance of hyperphosphorylated tau protein in neurons, astrocytes a

234 hFTAA also stained intracellular lesions of hyperphosphorylated Tau protein in P301S Tau transgenic

235 ation of misfolded amyloid-beta peptides and hyperphosphorylated tau protein in the brain.

236 Deposition of aggregates of hyperphosphorylated tau protein is a hallmark of tauopat

237 Accumulation of neurotoxic hyperphosphorylated TAU protein is a major pathological

238 We identified hyperphosphorylated tau protein using AT8 immunohistoche

239 ile plaques, neurofibrillary tangles made of hyperphosphorylated tau protein with neuronal loss.

240 , are characterized by insoluble deposits of hyperphosphorylated tau protein within brain neurons.

241 eurofibrillary tangles, formed of misfolded, hyperphosphorylated tau protein, are a pathological hall

242 elated tauopathies are composed of insoluble hyperphosphorylated Tau protein, but the mechanisms unde

243 protein and intracellular tangles containing hyperphosphorylated Tau protein.

244 ular neurofibrillary tangles, constituted by hyperphosphorylated tau protein.

245 tauopathies, are comprised of aggregates of hyperphosphorylated tau protein.

246 urofibrillary tangles composed of abnormally hyperphosphorylated tau protein.

247 contain neurofibrillary tangles comprised of hyperphosphorylated tau protein.

248 strated that neurofibrillary tangles made of hyperphosphorylated tau proteins are closely associated

249 eins (Abeta) and neurofibrillary deposits of hyperphosphorylated tau proteins are the diagnostic lesi

250 ptides in senile plaques and accumulation of hyperphosphorylated tau proteins in neurofibrillary tang

251 ead) by neurofibrillary tangles (composed of hyperphosphorylated tau proteins) based on the progressi

252 des, and neurofibrillary tangles composed of hyperphosphorylated tau proteins.

253 intracellular aggregation of abnormally and hyperphosphorylated tau proteins.

254 Tangles are composed of misfolded hyperphosphorylated tau proteins; however, the link betw

255 In contrast, pyramidal cells containing hyperphosphorylated tau retain monoacylglycerol lipase e

256 : neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau selectively affect pyramidal neu

257 cytosolic polyanions but negatively charged, hyperphosphorylated Tau that is condensed by cytosolic p

258 Compounds controlling the aggregation of hyperphosphorylated tau therefore are probable modulator

259 In TgF344-AD rats, hyperphosphorylated tau was detected in the locus coerul

260 abnormalities caused by the accumulation of hyperphosphorylated tau within intact dendritic spines,

261 and neurofibrillary tangles (NFTs) formed by hyperphosphorylated tau, a microtubule-associated protei

262 Accumulation of hyperphosphorylated tau, a microtubule-associated protei

263 Furthermore, accumulation of hyperphosphorylated tau, a microtubule-associated protei

264 ry tangles (NFTs), composed of truncated and hyperphosphorylated tau, are a common feature of numerou

265 les (NFTs), which are composed of abnormally hyperphosphorylated tau, but the mechanism of tau hyperp

266 rticular, p25/Cdk5 has been shown to produce hyperphosphorylated tau, neurofibrillary tangles as well

267 d activator p25, results in the formation of hyperphosphorylated tau, neuroinflammation, amyloid depo

268 Lewy body pathology and the accumulation of hyperphosphorylated tau, supporting a link between PLA2G

269 ciated kinases that promote the formation of hyperphosphorylated tau, the major component of neurofib

270 trate the feasibility and potential of using hyperphosphorylated tau-based assays for AD drug discove

271 mpal neurons expressing TERT did not contain hyperphosphorylated tau.

272 nomers, induce accumulation of pathological, hyperphosphorylated tau.

273 major pathologies: amyloid-beta (Abeta) and hyperphosphorylated tau.

274 of amyloid-beta (Abeta) and accumulation of hyperphosphorylated tau.

275 urite outgrowth and cause an accumulation of hyperphosphorylated Tau.

276 urofibrillary tangles composed of aggregated hyperphosphorylated tau.

277 a contributing factor to the accumulation of hyperphosphorylated Tau.

278 ed of paired helical filaments of abnormally hyperphosphorylated tau.

279 and its role in the formation of abnormally hyperphosphorylated tau.

280 e levels correlated with PHF-1 immunostained hyperphosphorylated tau.

281 ion and toxic proteinopathies of amyloid and hyperphosphorylated tau.

282 in (APP) and neurofibrillary tangles made of hyperphosphorylated Tau.

283 seases marked by intracellular aggregates of hyperphosphorylated Tau.

284 ls of Abeta, and a decrease in the levels of hyperphosphorylated tau.

285 rofibrillary tangles composed of aggregated, hyperphosphorylated tau.

286 ith a decline in the levels of total tau and hyperphosphorylated tau.

287 ques and neurofibrillary tangles composed of hyperphosphorylated tau.

288 cellular neurofibrillary tangles composed of hyperphosphorylated tau.

289 aracterized by intracellular accumulation of hyperphosphorylated tau.

290 y tangles and dystrophic neurites containing hyperphosphorylated tau.

291 ibrillary tangles, composed predominantly of hyperphosphorylated tau; and cerebral amyloid angiopathy

292 hsp110(-)(/)(-) mice exhibit accumulation of hyperphosphorylated-tau (p-tau) and neurodegeneration.

293 thology in a distribution pattern similar to hyperphosphorylated-tau.

294 smic accumulation of toxic ubiquitinated and hyperphosphorylated TDP-43 fragments and the loss of nor

295 lts in a dramatic reduction of insoluble and hyperphosphorylated TDP-43 that enhances cell survival,

296 ing increased the DNA relaxation activity of hyperphosphorylated topo I by enhancing its association

297 Hyperphosphorylated transactive response DNA-binding pro

298 These aggregates were hyperphosphorylated, Triton insoluble, and thioflavin-S

299 hies is thought to involve the generation of hyperphosphorylated, truncated, and oligomeric tau speci

300 we found the Arg-389 variant of ADRB1 to be hyperphosphorylated upon continuous stimulation with nor