ライフサイエンスコーパス: hypersensitive site

1 ted enzymes were unable to erase the DNase I-hypersensitive site.

2 activity and corresponds to a major DNase I-hypersensitive site.

3 esults in the appearance of multiple DNase I hypersensitive sites.

4 lso reiterated by their proximity to DNAse I-hypersensitive sites.

5 ct from, that observed for FAIRE and DNase I hypersensitive sites.

6 density, gene expression levels, and DNaseI hypersensitive sites.

7 t of nucleosome sequences containing KMnO(4) hypersensitive sites.

8 sites and greatly diminished at the DNase I hypersensitive sites.

9 the immediate 5' flanking region for DNase I hypersensitive sites.

10 her functional modalities encoded by DNase I hypersensitive sites.

11 in to either stably create or remove DNase I hypersensitive sites.

12 cers (hs3A, hs1,2, hs3B, and hs4) at DNase I-hypersensitive sites.

13 conditions caused rapid development of three hypersensitive sites.

14 T transcription start site and several minor hypersensitive sites.

15 binding within the LCR is restricted to the hypersensitive sites.

16 ome mobilization, which subsumed the DNase I hypersensitive sites.

17 ma cells by inducing and maintaining DNase I hypersensitive sites.

18 and termination sites, enhancers and DNase I hypersensitive sites.

19 r chromatin binding and induction of DNase I hypersensitive sites.

20 C with target-sequence enrichment of DNase I hypersensitive sites.

21 ct through binding events located in DNase I hypersensitive sites.

22 accessible regulatory DNA defined by DNase I hypersensitive sites.

23 associated histone modifications and DNase I hypersensitive sites.

24 n transcription-factor-binding-sites and DNA-hypersensitive-sites.

25 Deletion of this element, termed hypersensitive site 1 (HSS1), in a bacterial artificial

26 One region, DNase I-hypersensitive site 1 (HSS1), located 10 kb upstream of

27 rted between locus control region 5' DNase I-hypersensitive site 1 and the epsilon-globin gene was tr

28 folds from 1.36 to 3.1) as well as the DNase hypersensitive sites (1.58-2.42 fold), H3K4Me1 (1.23-1.4

29 ng in vivo in the beta-globin cluster to the hypersensitive site 2 (HS2) in the locus control region

30 element (MARE) in locus control region (LCR) hypersensitive site 2 (HS2) reveals a remarkably high de

31 ACCC site at -114 bp and enhancer sequences (hypersensitive site 2 [HS2]) from the beta-globin locus

32 The human beta-globin locus control region hypersensitive site 2 plays different roles on beta-glob

33 on of the 234-bp core element of the DNase I hypersensitive site 3 (5'HS3) of the locus control regio

34 We conclude that the GT6 motif of hypersensitive site 3 of the LCR is required for normal

35 Our studies revealed a cluster of hypersensitive sites 30 kb upstream of the most 5' VH ge

36 -SAR) and the chicken beta-globin 5' DNase I hypersensitive site 4 (5'HS4) insulator both separately

37 Thus, the chicken hypersensitive site 4 DNA insulator is sufficient to pro

38 from the chicken beta-globin locus, chicken hypersensitive site 4, which contains CCCTC binding fact

39 gene led to the identification of a DNase I hypersensitive site 4.5 kb upstream of the Ly49A gene tr

40 Previous studies demonstrated that DNase I hypersensitive site -40 (HS-40) of the alpha-globin locu

41 odifications revealed that deletion of Rad50 hypersensitive site 6 impacted epigenetic modifications

42 These studies indicated that Rad50 hypersensitive site 6 was the singularly most important

43 Among these sites, Rad50 hypersensitive site 7 (RHS7) shows rapid T(H)2-specific

44 rad50 hypersensitive site 7 (RHS7), a hypersensitive site with

45 We used DNase-chip to identify DNase I hypersensitive sites accurately from a representative 1%

46 s and by mapping the previously known DNaseI hypersensitive sites across 240 kb of the human alpha-gl

47 ated the ADHM protocol by mapping the DNaseI hypersensitive sites across 250 kb of the human TAL1 loc

48 es a powerful approach to identifying DNaseI hypersensitive sites across large genomic regions.

49 a shared region of 39 kb that contains DNAse hypersensitive sites active at a restricted time window

50 equence homology analysis as well as DNase I-hypersensitive site analysis.

51 periments revealed that, although all of the hypersensitive sites analyzed are important for appropri

52 of the core promoter that contains a DNase I hypersensitive site and directs high level, erythroid-sp

53 r from EKLF-deficient cells lacked a DNase I hypersensitive site and exhibited histone hypoacetylatio

54 A DNase I hypersensitive site and extragenic transcripts at IFNgCN

55 Global analyses of DNase I-hypersensitive sites and 3D genome architecture, linking

56 ssible chromatin by global mapping of DNaseI hypersensitive sites and analyzed enriched TF-binding mo

57 Each enhancer contains DNase I-hypersensitive sites and appears to confer developmental

58 igh-throughput, automated mapping of DNase I-hypersensitive sites and associated cis-regulatory seque

59 lowed us to identify a number of novel DNase hypersensitive sites and characterize more distant regul

60 f functional elements, as we show for DNaseI hypersensitive sites and highly conserved regions with d

61 These elements contain DNase I hypersensitive sites and histone modification patterns c

62 l region (LCR), composed of multiple DNase I-hypersensitive sites and located far upstream of the gen

63 gh-throughput approach, we discovered DNaseI hypersensitive sites and potential regulatory elements a

64 ated gene 1 complex induces promoter DNase I hypersensitive sites and recruits other transcription fa

65 is region contained newly identified DNase I-hypersensitive sites and several CTCF target sites, some

66 e structure within about 1.6 million DNase I-hypersensitive sites and show that the overwhelming majo

67 mplexes are recruited to a subset of DNase I hypersensitive sites and to conserved noncoding sequence

68 overlap endogenous erythroid-specific DNase hypersensitive sites, and 1 of which includes the proxim

69 -5.3 kb, the promoter, the intronic DNase I hypersensitive sites, and 3' distal sites including the

70 ipts, double-strand-break hotspots and DNase hypersensitive sites, and can distinguish genes by expre

71 ranscription start sites, CpG islands, DNase-hypersensitive sites, and gene-dense regions; all are fe

72 for 17 TFs, 3 histone modifications, DNase I hypersensitive sites, and high-resolution promoter-enhan

73 ssible chromatin comprising clustered DNaseI hypersensitive sites, and that replication time is bette

74 Traditional methods used to identify DNaseI hypersensitive sites are cumbersome and can only be appl

75 Here we report identification of a DNaseI hypersensitive site at the 3' end of the Scl/Map17 domai

76 tein TFE3 was sufficient to induce a DNase I-hypersensitive site at the immunoglobulin heavy chain mi

77 nd cell division involves the formation of a hypersensitive site at the insulator during chromatin ma

78 did not participate in the formation of the hypersensitive site at the tRNA.

79 ription factor motifs in deoxyribonuclease I hypersensitive sites at cell-type-specific epigenetic lo

80 tion, we have identified two tissue-specific hypersensitive sites at the 5' CR of the PD-1 locus.

81 accompanied by the loss of multiple DNase I hypersensitive sites at the TERT promoters and their ups

82 tin architecture reflected by major nuclease hypersensitive sites, atypical distribution of epigeneti

83 e replacement closely correspond to nuclease-hypersensitive sites, binding sites for Polycomb and tri

84 The Lockd promoter contains a DNase-hypersensitive site, binds numerous transcription factor

85 te that both the distal and proximal DNase I-hypersensitive sites characteristic of the transcription

86 d in chicken lung overlapped half of DNase-I hypersensitive sites, coincided with active histone modi

87 in wild-type cells, suggesting that the four hypersensitive sites contain most of the CSR-promoting f

88 gene comprises a 220 bp micrococcal nuclease hypersensitive site corresponding to the promoter regula

89 We demonstrate DNase hypersensitive sites corresponding to the lymphotoxin al

90 in various cells using Encode Roadmap DNase-hypersensitive site data.

91 co-occurring DNA motifs in 349 human DNase I hypersensitive site datasets.

92 An additional hypersensitive site developed rapidly only under Th2 con

93 An airway-selective DNase-hypersensitive site (DHS) at kb -35 (DHS-35kb) 5' to the

94 Here we present PlantDHS, a plant DNase I hypersensitive site (DHS) database that integrates histo

95 ce, which leverages cell-type specific DNAse Hypersensitive Site (DHS) information from the NIH Epige

96 d that allows us to generate maps of DNase I-hypersensitive site (DHS) of mouse preimplantation embry

97 uman silencers, we utilized H3K27me3-DNase I hypersensitive site (DHS) peaks with tissue specificity

98 vivo and encompasses a male-specific DNase I hypersensitive site (DHS).

99 y chromatin environments and mapped to DNase-hypersensitive sites (DHS) classified by sex bias in chr

100 We previously mapped DNase I hypersensitive sites (DHS) in 400 kb spanning the CFTR l

101 fication of hundreds of thousands of DNase I hypersensitive sites (DHS) per cell type has been possib

102 sequence corresponding to human CFTR DNase I hypersensitive sites (DHS) showed high homology in the c

103 scription of Ikaros, tissue-specific DNase I-hypersensitive sites (DHS) were mapped throughout the Ik

104 MRs mark an exclusive subset of active DNase hypersensitive sites (DHS), and that both developmentall

105 zes with the PWS-IC and contains two DNase I hypersensitive sites, DHS1 at the SNRPN promoter, and DH

106 DNase I hypersensitive sites (DHSs) are a hallmark of chromatin

107 DNase I hypersensitive sites (DHSs) are generic markers of regul

108 DNase I hypersensitive sites (DHSs) are markers of regulatory DN

109 sistent patterns of gain and loss of DNase I-hypersensitive sites (DHSs) as cells progress from embry

110 tory elements; therefore, mapping of DNase I hypersensitive sites (DHSs) enables the detection of act

111 polymorphisms (SNPs) and deoxyribonuclease I hypersensitive sites (DHSs) from 112 different cell type

112 ale maps of regulatory DNA marked by DNase I hypersensitive sites (DHSs) from 138 cell and tissue typ

113 e standard approach to locating these DNaseI-hypersensitive sites (DHSs) has been to use Southern blo

114 , we mapped >1.3 million deoxyribonuclease I-hypersensitive sites (DHSs) in 45 mouse cell and tissue

115 drive gene-expression changes though DNase-I hypersensitive sites (DHSs) near transcription start sit

116 DNase I hypersensitive sites (DHSs) provide important informatio

117 However, an extended analysis of DNase I-hypersensitive sites (DHSs) spanning the entire upstream

118 Over half of embryonic DNase I hypersensitive sites (DHSs) were annotated as noncoding,

119 cytes and glioma cells, six specific DNase I-hypersensitive sites (DHSs) were found located exclusive

120 We associated DNase I hypersensitive sites (DHSs) with genes, and trained clas

121 t defined more than 1800 clusters of DNase I hypersensitive sites (DHSs) with similar tissue specific

122 AP-1 which created thousands of new DNase I-hypersensitive sites (DHSs), enabling ETS-1 and RUNX1 re

123 ave created genome-scale catalogs of DNase I hypersensitive sites (DHSs), which demark potentially fu

124 s in promoter regions that intersect DNase I hypersensitive sites (DHSs).

125 DNA marked by deoxyribonuclease I (DNase I) hypersensitive sites (DHSs).

126 ry DNA elements can be identified as DNase I hypersensitive sites (DHSs).

127 bility and DNA methylation patterns at DNase hypersensitive sites (DHSs).

128 associated with regulatory elements, DNase I hypersensitive sites (DHSs).

129 d by a 150 kb domain comprised of 16 DNase I hypersensitive sites (DHSs).

130 ormation of 17 expression-associated DNase I-hypersensitive sites (DHSs).

131 ory DNA elements are associated with DNase I hypersensitive sites (DHSs).

132 Two strong DNase I-hypersensitive sites (DHSSs) were identified in the IL-1

133 a functional role for an intergenic DNase I hypersensitive site distal to LTA in Jurkat cells based

134 Sequencing of DNase I hypersensitive sites (DNase-seq) is a powerful technique

135 nclude that favored integration near DNase I-hypersensitive sites does not imply that integration tak

136 developmentally specific erythroid enhancer, hypersensitive site-embryonic 1 (HS-E1), located within

137 DNase I hypersensitive sites exhibit marked aggregation around t

138 In particular, hypersensitive sites flanking the Cse4 containing nucleo

139 n approach that can rapidly identify DNase I hypersensitive sites for any region of interest, or pote

140 specific small hairpin RNA inhibits DNase I hypersensitive site formation and down-regulates target

141 However, GATA-1 binding, DNase I hypersensitive site formation and several histone modifi

142 AP-1 elements that colocalized with DNase I-hypersensitive sites found in astrocytes and glioma cell

143 art sites, most often contained within DNase hypersensitive sites, frequently conserved, and near gen

144 -50), and a novel Sarkosyl-sensitive DNase I-hypersensitive site generated by Ets-1 binding to chroma

145 n start sites, reduces the number of DNase I-hypersensitive sites genome wide, and decreases the numb

146 with, and maintain the intensity of DNase I hypersensitive sites genome wide, in resting but not in

147 ion (LCR), was revealed by analyzing DNase I hypersensitive sites, H3K4 trimethylation marks and GATA

148 An MSL-binding site (DHS, DNaseI hypersensitive site) has been identified in each roX gen

149 The 3' Igh enhancers, DNase I hypersensitive site (hs) 3B and/or hs4, are required for

150 Here we focus on DNase hypersensitive site (HS) 6 of the TCRalpha LCR.

151 We previously identified two upstream hypersensitive site (HS) clusters in mast cells and mela

152 function of the locus control region DNase I hypersensitive site (HS) core elements.

153 inants of this activity coincide with DNaseI hypersensitive site (HS) I of the LCR.

154 DNase I hypersensitive site (HS) mapping revealed five liver-spe

155 (ANK1E) core promoter contains a 5' DNase I hypersensitive site (HS) with barrier insulator function

156 t it is phosphorylated and lost over DNase I hypersensitive site (HS)2, HS3, HS4, and the human beta-

157 However, at DNase I-hypersensitive site (HS)3 of the beta-globin locus contr

158 We previously defined novel DNase I hypersensitive sites (hs) 5, 6, 7 immediately downstream

159 l promoter displays three constitutive DNase hypersensitive sites (HS) and a moderate level of histon

160 The LCR is marked by five DNase I-hypersensitive sites (HS) approximately 15 kb upstream o

161 Several deoxyribonuclease (DNase) I-hypersensitive sites (HS) have been located in the dista

162 This LCR is composed of DNase I-hypersensitive sites (HS) located -14.5 kb to -32 kb rel

163 ent physically characterized by five DNase I-hypersensitive sites (HS), designated HS1-HS5.

164 normal cells and is spanned by three DNase I-hypersensitive sites (HS).

165 t a 650-bp sequence corresponding to DNase I hypersensitive sites HS1-2 within the mouse Igkappa gene

166 Thus, our studies demonstrate that DNase I hypersensitive sites HS1-2 within the Vkappa-Jkappa inte

167 This silencer activity requires DNase I hypersensitive sites HS2 and HS3 but not HS4.

168 An evolutionarily conserved DNase hypersensitive site (HS3) within intron 2 was found to a

169 These elements, hypersensitive site (HSS)-9 and HSS+3 (9 kb upstream and

170 Strikingly, a novel DNase I-hypersensitive site (HSS-4.5) was identified in stimulat

171 ctive globin genes, as well as the remote 5' hypersensitive sites (HSs) (HS-60/-62 in mouse, HS-110 i

172 hey can be detected experimentally as DNaseI hypersensitive sites (HSs) in vivo, though the process i

173 noncoding regulatory elements within DNase I-hypersensitive sites (HSS) located 9 kb upstream (HSS-9)

174 Clusters of epidermal-specific DNaseI-hypersensitive sites (HSs) mapped to specific CNSs.

175 The DNaseI hypersensitive sites (HSs) of the human beta-globin locu

176 The LCR encompasses 6 DNaseI hypersensitive sites (HSs) that bind transcription facto

177 The overall structure of the DNase I hypersensitive sites (HSs) that comprise the beta-globin

178 by two partially overlapping sets of DNase I hypersensitive sites (HSs) that constitute the pituitary

179 ne the contribution of individual LCR DNaseI hypersensitive sites (HSs) to transcription and nuclear

180 ch for genome-scale identification of DNaseI hypersensitive sites (HSs) via isolation and cloning of

181 the transcriptionally active state, DNase I hypersensitive sites (HSs) were detected at the -3.9- an

182 ning a defined set of liver-specific DNase I hypersensitive sites (HSs), is robustly expressed in mou

183 The LCR is composed of a number of DNase I-hypersensitive sites (HSs), which are believed to encomp

184 ll characterized LCR containing four DNase I hypersensitive sites (HSs).

185 n (LCR) composed of five deoxyribonuclease I hypersensitive sites (HSs).

186 tary-specific locus control elements DNase I-hypersensitive site I (HSI) and HSII, located 14.5 kb 5'

187 DNase I-hypersensitive site I (HSI) of the LCR is essential to f

188 Pituitary-specific DNase I hypersensitive site I (HSI), the dominant hGH LCR elemen

189 isruptive mutations within fetal CNS DNase I hypersensitive sites (i.e., putative regulatory regions)

190 ally, a lipopolysaccharide-inducible DNase I hypersensitive site identified 10 kb upstream of the sta

191 s information from H3K27ac signal at DNase I hypersensitive sites identified from published human and

192 uadruplexes strongly associate with nuclease hypersensitive sites identified throughout the genome vi

193 We describe three paternal-specific nuclease hypersensitive sites immediately upstream from the start

194 In transgenic mice, these hypersensitive sites impart strong, Th2-specific enhance

195 nhancer, we show that TFE3 induces a DNase I-hypersensitive site in an ATP-dependent reaction that re

196 xhibits a plasmacytoma cell-specific DNase I-hypersensitive site in chromatin, henceforth termed HS10

197 site mapping demonstrated the presence of a hypersensitive site in the 5' flanking region of the hEP

198 his technique enables genome-wide mapping of hypersensitive sites in a wide range of cell populations

199 ypermethylation signature enriched for DNase Hypersensitive Sites in acute myeloid leukemia.

200 The identification of nuclease-hypersensitive sites in an active globin gene and in the

201 erization of the most highly mutated DNase I hypersensitive sites in breast cancer (using in silico a

202 didate noncoding driver mutations in DNase I hypersensitive sites in breast cancer and experimentally

203 enoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines.

204 DNase I-hypersensitive sites in cellular chromatin are usually b

205 tion were positively correlated with DNase I-hypersensitive sites in chromatin.

206 We map the location of 17 DNase I-hypersensitive sites in different murine T cell populati

207 e observed significant enrichment in DNase I hypersensitive sites in fetal heart and lung.

208 we profile parental allele-specific DNase I hypersensitive sites in mouse zygotes and morula embryos

209 the TNF gene, respectively), contain DNase I hypersensitive sites in naive, T helper 1, and T helper

210 protein-coding genes, enhancers, and DNase-I hypersensitive sites in over 100 tissues and cell lines.

211 itro mapping of the nucleosome positions and hypersensitive sites in specific genes such as the yeast

212 One of the three nuclease hypersensitive sites in the Fab-7 boundary, HS1, contain

213 rate localization of the majority of DNase I-hypersensitive sites in the human genome without requiri

214 fraction of the proviruses) of both DNase I hypersensitive sites in the long terminal repeats and in

215 tin structure were the occurrence of DNase I-hypersensitive sites in the promoter region of nearly ev

216 We identify several DNase I-hypersensitive sites in the SLP-76 locus, with a promine

217 ld tend to contain more micrococcal nuclease hypersensitive sites in their promoters, a proxy for ope

218 ects Mi2beta to erase an established DNase I-hypersensitive site, in an ATP-dependent reaction subseq

219 d NucDHS, a nucleosome that covers the DNase hypersensitive site, in unintegrated viral DNA.

220 Bound regions covered 80% of DNase I hypersensitive sites including 99.7% of TSS and 98% of e

221 Analysis of DNase I hypersensitive sites indicated that only two of these ma

222 at the occupancy of nucleosomes at a DNase I hypersensitive site is a developmental stage-related eve

223 This DNase I-hypersensitive site is the only known regulatory element

224 Mapping DNase I hypersensitive sites is an accurate method of identifyin

225 from everywhere in the Il4-Il13 locus except hypersensitive site IV, suggesting a critical role for t

226 DNA fragment including only its four DNase I hypersensitive sites (lacking the large spacer regions)

227 by a 3.4-kb DNA fragment including a DNase I hypersensitive site located 14 kb upstream of the transc

228 uence element mapping to a chromatin DNase I hypersensitive site located within intron 1.

229 ammalian cohesins occupy a subset of DNase I hypersensitive sites, many of which contain sequence mot

230 novel genomic array-based approach to DNaseI hypersensitive site mapping (ADHM) that permits precise,

231 xperimental approaches - for example, DNaseI hypersensitive site mapping and analysis of chromatin in

232 By hypersensitive site mapping and chromosome conformation

233 We first performed DNase I hypersensitive site mapping and demonstrated that the pr

234 In this study, DNaseI hypersensitive site mapping demonstrated the presence of

235 Here we utilized DNase I hypersensitive site mapping, chromatin immunoprecipitati

236 nucleosome positioning for MNase-seq, DNase hypersensitive site mapping, site annotation and motif i

237 me as accessible, with the majority of MNase hypersensitive sites marking proximal promoters, but als

238 Here, we identify a double DNaseI hypersensitive site, mHS-25/6, as having erythroid but n

239 ched with MH-seq reads are referred as MNase hypersensitive sites (MHSs).

240 h tri-methyl K4 of histone H3, correspond to hypersensitive sites, notably in exon 4 of LTB.

241 In the vicinity of active genes and DNase I hypersensitive sites nucleosomes are organized into peri

242 Nuclease-hypersensitive sites occur in species from yeast to huma

243 n with the restriction enzyme Fnu4HI reveals hypersensitive sites occurring approximately 125 bp apar

244 promoter was found to be localized in DNaseI hypersensitive site of chromatin in cancer cells but not

245 demonstrate that nucleosomes at the DNase I hypersensitive sites of the LCR could be either depleted

246 l level; and formation of all the 5' DNase I hypersensitive sites of the LCR was disrupted.

247 ofile across the whole locus; the 5' DNase I hypersensitive sites of the LCR were formed, but to a le

248 The DNase I hypersensitive sites of the LCR were well formed and the

249 s strong enhancer regions containing DNase I hypersensitive sites overlapping the rs874040 linkage di

250 iated with the appearance of a major DNase I-hypersensitive site positioned around the hTERT transcri

251 served functional enhancer marked by DNase 1 hypersensitive sites present upstream of the gene.

252 ction with the RNA polymerase, and a DNase I-hypersensitive site, pronounced in the promoter DNA of t

253 were capable of pinpointing the most likely hypersensitive sites related to cell-type-specific expre

254 Establishing and erasing the DNase I-hypersensitive site required transcriptional activation

255 Genome-wide mapping of DNase I hypersensitive sites revealed an open chromatin region b

256 gene RAD50, containing several RAD50 DNase1-hypersensitive sites (RHS), have been robustly associate

257 which is characterized by four Rad50 DNase I hypersensitive sites (RHS4-7).

258 Further, one of the hypersensitive sites (RHS7) is rapidly demethylated in T

259 ing (snDrop-seq) and single-cell transposome hypersensitive site sequencing (scTHS-seq).

260 n sequencing and microarray data and DNase I hypersensitive site sequencing data.

261 In this study, we applied DNase-seq (DNase I hypersensitive site sequencing) to study changes of chro

262 precipitation sequencing (ChIP-seq), DNase I hypersensitive sites sequencing (DNase-seq), and whole-g

263 We present a transposome hypersensitive sites sequencing assay for highly sensiti

264 Analysis of DNase I hypersensitive sites sequencing data revealed an open ch

265 sequence alone, with the highest accuracy at hypersensitive sites shared across cell types.

266 beta-globin locus, well-established DNase I hypersensitive sites stand out against a background in w

267 blockade did not redistribute Pol II at the hypersensitive sites, suggesting that Pol II is recruite

268 single guide RNA libraries to target DNase I hypersensitive sites surrounding a gene of interest, we

269 e also discovered a cell-type specific DNase hypersensitive site that maps to the Sp1/Sp3 and adjacen

270 genes with paternal allele-specific DNase I hypersensitive sites that are devoid of DNA methylation

271 ecific footprints were detected within DNase hypersensitive sites that are present in multiple cell t

272 We identify ten DNase I hypersensitive sites that are significantly mutated in b

273 ns are, however, highly enriched for DNase I-hypersensitive sites that comprehensively mark cell-type

274 DNase I hypersensitive sites that comprise the T(H)2 LCR develop

275 occurs primarily within narrow, highly DNase hypersensitive sites that frequently coincide with trans

276 he traditional method of identifying DNase I hypersensitive sites, the conventional manual method is

277 remodeling and formation of multiple DNase I-hypersensitive sites throughout the locus.

278 (DRR) containing previously described DNaseI hypersensitive sites, to allow direct comparison between

279 site methylation, CGIs, co-localized DNase I hypersensitive sites, transcription factor binding sites

280 s DNA coincident with the location of DNaseI hypersensitive sites, transcriptional start sites, and a

281 ation analysis indicated that NF-E2 occupies hypersensitive site two (HS2) of the beta-globin locus c

282 By analyzing the DNase I hypersensitive sites under 349 experimental conditions,

283 We provide evidence that DNaseI hypersensitive site V in the Il4 3' enhancer is the like

284 Enrichment of SNPs associated with DNase I-hypersensitive sites was also found in many tissue types

285 However, correlations with DNase I hypersensitive sites were different for all vectors, ind

286 veral traits, and cell-type-specific DNase-I hypersensitive sites were enriched with SNPs associated

287 We found that although most DNase I hypersensitive sites were present in both cell types stu

288 We found that 40% DHSs (DNaseI hypersensitive sites) were diminished under darkness.

289 anscription in the presence and absence of a hypersensitive site, whereas endonuclease accessibility

290 arge (100-500 kb) 'superclusters' of DNase I hypersensitive sites, which encompass both gene-rich and

291 functional elements coinciding with DNase I hypersensitive sites will substantially expand our knowl

292 sitions of 4 histone modifications and DNase hypersensitive sites, Wilson et al reveal many more of t

293 of the KRAS gene contains a GC-rich nuclease hypersensitive site with three potential DNA secondary s

294 ergenic transcription start sites and DNaseI hypersensitive sites with allelic differences.

295 wherein we localized 2,690 classical DNase I hypersensitive sites with high sensitivity and specifici

296 We identified 71,264 hypersensitive sites, with 1,284 showing robust sex-rela

297 rad50 hypersensitive site 7 (RHS7), a hypersensitive site within this LCR, becomes demethylate

298 the presence of a single cluster of DNase I hypersensitive sites within the 5' flanking region, and

299 ting regions correspond to prominent DNase I hypersensitive sites within the locus.

300 fic demethylation were restricted to DNase I hypersensitive sites within this locus.