ライフサイエンスコーパス: hypo-

1 and lower MCAv(mean) , but similar CVR(HYPER/HYPO) .

2 7 regions/person while 2 control boys (hyper/hypo: 0/2) and 2 control girls (hyper/hypo: 1/1) met the

3 nsor response may be customized to cover the hypo- (0-80 mg/dL), normo- (80-120 mg/dL), and hyperglyc

4 (hyper/hypo: 0/2) and 2 control girls (hyper/hypo: 1/1) met the same criteria in only 1 region/person

5 oys (hyper/hypo: 7/9) and 10 PM girls (hyper/hypo: 2/5, 3 both) displayed aberrant LGI in 1-17 region

6 nce of normal first-pass signal enhancement (HYPO), (2) normal first pass signal followed by hyperenh

7 Sixteen PM boys (hyper/hypo: 7/9) and 10 PM girls (hyper/hypo: 2/5, 3 both) dis

8 week 1, %S was depressed in HYPER, COMB, and HYPO (9+/-8%, 7+/-6%, and 5+/-4%, respectively) and were

9 dance of 462 proteins and altered (hyper- or hypo-) acetylation of 436 lysine residues on 350 protein

10 PFC), nucleus accumbens (NAC), hypothalamus (HYPO), amygdala (AMY), and hippocampal CA1 and CA3.

11 Hypodiploid (Hypo) and BCR::ABL1-positive (BCR-ABL+) B-cell precursor

12 nd a normal oncogenic Nras allele (Nras G12D(hypo) and Nras G12D, respectively) to create a gene dose

13 d not differ significantly between BCR-ABL+, Hypo, and Neither patients, respectively.

14 The stages of hyper-, hypo-, and hyper-methylation patterns of the CDX1 promot

15 Gene Expression Omnibus datasets led to 917 hypo- and 654 hyper-methylated DMGs.

16 iving Scale), potential prediagnostic motor (hypo- and bradykinesia, tremor, rigidity, postural imbal

17 onset progressive peripheral neuropathy with hypo- and demyelination, slowing of nerve conduction vel

18 re up-regulated in L-NCoRDeltaID mice in the hypo- and euthyroid state, there was little effect seen

19 steopontin phosphorylation level declined in hypo- and hyper- phosphatemia mouse models exhibiting sk

20 ation, ranging from 4 to100 mM (covering the hypo- and hyper-glycemia range, useful in diabetes).

21 However, both hypo- and hyper-O-GlcNAcylation cause GlcNAz to redistri

22 n(2+)-binding pocket generated variants both hypo- and hyper-resistant to zinc starvation, and both m

23 Heterogeneous default mode network hypo- and hyper-RSFC across the factors might explain pr

24 d three factors with dissociable whole-brain hypo- and hyper-RSFC patterns.

25 A wild-type strain outcompeted both hypo- and hyperaccumulating strains, suggesting that gly

26 ause distinct effects on catalysis including hypo- and hyperactivity and altered fidelity.

27 compulsive-like actions have been linked to hypo- and hyperactivity of orbital frontal cortex (OFC)-

28 AF illustrated a speckled macular network of hypo- and hyperautofluorescence colocalized with multifo

29 During dietary-induced hypo- and hypercalcemia (0.59+/-0.06 and 1.58+/-0.12 mM

30 PTH-iCa curves were constructed by inducing hypo- and hypercalcemia through alterations in dialysate

31 ASR) gene and cause human autosomal dominant hypo- and hypercalcemic disorders.

32 aR) that are associated with inherited human hypo- and hypercalcemic disorders.

33 w Pico2 measurements during induced systemic hypo- and hypercapnia.

34 econciled seemingly disparate themes of both hypo- and hyperconnectivity in the ASD literature; both

35 or the seemingly paradoxical observations of hypo- and hyperconnectivity reported in the literature.

36 m was associated with a brainwide pattern of hypo- and hyperconnectivity.

37 ificant for MAR in hypodense and VMI(MAR) in hypo- and hyperdense artifacts (p < 0.05).

38 nd standard deviation of attenuation (HU) in hypo- and hyperdense artifacts from coils and clips.

39 Visually, hypo- and hyperdense artifacts were significantly reduce

40 c value in treating disorders resulting from hypo- and hyperdopaminergic activity, without the side e

41 yT1+/-), to determine how constitutive NMDAR hypo- and hyperfunction, respectively, affect the glutam

42 This study was designed to determine whether hypo- and hyperglycaemia modulate the hypoxic ventilator

43 show for the first time that PHHs exposed to hypo- and hyperglycemia can remain highly functional, bu

44 olling glucagon and insulin secretion during hypo- and hyperglycemia, respectively, the dose-response

45 crease the risks of extremes in BG including hypo- and hyperglycemia.

46 y, whereas areas of regeneration appeared as hypo- and hyperintense.

47 Dietary hypo- and hyperkalemia (2.8 +/- 0.1 and 6.8 +/- 0.3 mM)

48 sants, a combination of glucose and insulin, hypo- and hyperkalemia, hypercalcemia, and alcohol and c

49 disorders (periodic ataxia with myokymia and hypo- and hyperkalemic periodic paralysis) are due to mu

50 mGlu receptor ligands for treatment of both hypo- and hyperkinetic disorders of basal ganglia origin

51 ing software (SPM5) was used to identify all hypo- and hypermetabolic regions in patients with HD rel

52 atients showed a nearly identical pattern of hypo- and hypermetabolism in groups 1 and 2.

53 d (18)F-FDG uptake (regions with significant hypo- and hypermetabolism in patients with conversion vs

54 les of females; (v) the general dichotomy of hypo- and hypermethylated alleles persisted over the 5 y

55 nexpectedly, the sequence characteristics of hypo- and hypermethylated domains in cerebellum were dis

56 We discover pancancer hypo- and hypermethylated genes and identify novel methy

57 t that exploit this vast dataset to identify hypo- and hypermethylated genes in cancer.

58 tion levels, thus the dual stability of both hypo- and hypermethylated genomic regions, and (3) spora

59 that in most cell types, the age-associated hypo- and hypermethylated sites were enriched for ARNT (

60 lation is generally faithfully maintained at hypo- and hypermethylated sites, this is not the case at

61 e maternally and paternally derived ICRs are hypo- and hypermethylated, respectively, with the former

62 Age-associated hypo- and hypermethylation events occur at distinct regu

63 sites were associated with lineage-specific hypo- and hypermethylation in different cell types, sugg

64 enomic (TP53, RB1, CYLD, AR) and epigenomic (hypo- and hypermethylation of 20 differential sites) alt

65 We report hypo- and hypermethylation of genes within functional ca

66 s this an attractive technique to study both hypo- and hypermethylation of regions of the genome like

67 tterns were similar to those in mammals, and hypo- and hypermethylation were predictive of increased

68 gene sequences was studied as a hallmark of hypo- and hypermethylation, respectively.

69 Ingestion of water and food are major hypo- and hyperosmotic challenges.

70 , we assess the sensitivity of TRPM7 to both hypo- and hyperosmotic conditions and explored the invol

71 perturbation of COPI function, because both hypo- and hyperosmotic conditions slowed brefeldin A-ind

72 rent magnitude, as well as under consecutive hypo- and hyperosmotic conditions.

73 ase (39%) in glutamine uptake in response to hypo- and hyperosmotic exposure, respectively.

74 changes in glycogen synthesis resulting from hypo- and hyperosmotic exposure.

75 (i) The relative amounts of hypo- and hyperphosphorylated EF-1delta in Vero cells in

76 plication and virion assembly, and exists in hypo- and hyperphosphorylated forms.

77 2A, resulting in dynamic equilibrium between hypo- and hyperphosphorylated isoforms of CLK.

78 Thus, an activity-dependent switch between hypo- and hyperphosphorylation at S1586 and S1615 of Sha

79 ve and regulated pre-mRNA splicing; yet both hypo- and hyperphosphorylation of SR proteins are known

80 The patients presented with hypo- and hyperpigmented macules over the body, resembli

81 and pathologic alterations involved in organ hypo- and hyperplasia and cancer.

82 he cilial protein Evc in mice causes various hypo- and hyperplasia defects during molar development.

83 changes in aortic cross-sectional area with hypo- and hypertension did not appreciably improve the p

84 Both the hypo- and hyperthermia phases were associated with a red

85 vivo, we expressed a biotinylated TRbeta1 in hypo- and hyperthyroid mouse livers, used ChIP-seq to id

86 we examined T3-regulated gene expression of hypo- and hyperthyroid transgenic mice.

87 g the zebrafish a very useful model to study hypo- and hyperthyroidism in other vertebrate taxa, incl

88 nditions in which they are implicated, i.e., hypo- and hyperthyroidism.

89 rine dysfunctions such as Graves disease and hypo- and hyperthyroidism.

90 om Necturus basolateral membranes respond to hypo- and hypertonic challenge monotonically around an i

91 DV volume and pH changes upon ATP depletion, hypo- and hypertonic shock, and rapid withdrawal of perf

92 inistration of CO(2) as well as by voluntary hypo- and hyperventilation at rest and during steady-sta

93 0.29; P =.001) and better depicted regional hypo- and hyperventilation.

94 ce distinguishing in hyper-inflated, normo-, hypo- and non-aerated pulmonary compartments.

95 plitudes were quite variable with some being hypo- and others hypermetric.

96 volume overload and/or hypovolemia, avoiding hypo- and/or hypertension, treating pain and anaemia to

97 suggesting that the specific cause of vermal hypo-/aplasia precedes this defect.

98 e, anterior hypothalamic (hypo.) n., lateral hypo. area (most extensive and dense message), periventr

99 In exosome mutants, hypo- as well as hyperadenylated mRNAs are released and

100 Rpd3 and Hda1 overlap extensively with Lys 4 hypo- but not hypermethylated regions.

101 engineered betaTrCP was capable of selecting hypo- but not hyperphosphorylated forms of retinoblastom

102 erquartile range (IQR) = -94 to -44] and CVR(HYPO) by 50% (IQR = -83 to -33) (treatment-effect; all P

103 ry responses from a subsequent hypoglycemic (HYPO) clamp.RESULTSLow and intermediate MMTT C-peptide g

104 Mice expressing Nras G12D(hypo)/G12D(hypo) develop normally and are tumor-free, whereas early

105 lower in the ANTE HYPO group versus the ANTE HYPO + DHEA-S group (2.0 +/- 0.2 vs. 3.3 +/- 0.6 nmol/l;

106 us the ANTE EUG, ANTE EUG + DHEA-S, and ANTE HYPO + DHEA-S groups (13 +/- 5 vs. 32 +/- 3, 38 +/- 7, a

107 us the ANTE EUG, ANTE EUG + DHEA-S, and ANTE HYPO + DHEA-S groups (57 +/- 8 vs. 22 +/- 5, 18 +/- 6, a

108 us the ANTE EUG, ANTE EUG + DHEA-S, and ANTE HYPO + DHEA-S groups (P < 0.05).

109 travenous infusion of DHEA-S (30 mg/kg; ANTE HYPO + DHEA-S).

110 mice with 1% of wild-type St14 levels (St14(hypo/-)) display aberrant processing of profilaggrin and

111 evidence that genome-wide cancer hyper- and hypo- DNA methylation patterns are independent processes

112 poglycemia (2.8 +/- 0.1 mmol/l; n = 12; ANTE HYPO), euglycemia (6.2 +/- 0.1 mmol/l; n = 12; ANTE EUG)

113 Mice expressing Nras G12D(hypo)/G12D(hypo) develop normally and are tumor-free, wh

114 Moreover, CD18(hypo) gammadelta T cells induced allogeneic CD4(+) T cel

115 Areas of cortical lobar hypo (hyper)-metabolism in the cerebrum that were 2 SDx

116 roperties, block of particular channels, and hypo-/hyperkalemia.

117 2, and 11.7 2.0 mm Hg h(-1) in groups Hyper, Hypo, Hypo-Baseline, and Hypo-ECCO(2)R, respectively (P

118 (2VO) or 2VO plus systemic hypotension (2VO+Hypo; mean arterial pressure=30+/-2 mmHg) for 10-20 min.

119 arial baseline prevalence (representative of hypo-, meso-, and hyperendemic areas).

120 7,537 differentially (46.6% hyper- and 53.4% hypo-) methylated regions.

121 erns of statistically significant hyper- and hypo- methylation in comparisons involving any number of

122 disease.Methods: FSTL-1 hypomorphic (FSTL-1 Hypo) mice underwent lung morphometry, pulmonary functio

123 Wild-type (WT) and FSTL-1 hypomorphic (Hypo) mice were infected with Klebsiella pneumoniae to d

124 ylogeny and community structure between St14(hypo/-) mice and control littermates.

125 St14(hypo/-) mice have a selective shift in resident skin mic

126 St14(hypo/-) mice provide early evidence that the cutaneous m

127 n = 4); 48 hours of hypoventilation (group "Hypo," n = 4); 24 hours of hypoventilation plus 24 hours

128 e pallial commissure, anterior hypothalamic (hypo.) n., lateral hypo. area (most extensive and dense

129 po. n., stratum cellulare externum, inferior hypo. n., infundibular hypo. n., median eminence, three

130 xtensive and dense message), periventricular hypo. n., lateral to the paraventricular n., ventromedia

131 re externum, inferior hypo. n., infundibular hypo. n., median eminence, three layers within the strat

132 eral to the paraventricular n., ventromedial hypo. n., stratum cellulare externum, inferior hypo. n.,

133 al cell and astrocyte production of NO under hypo-, normo- and hypercapnic conditions.

134 Here, we exposed MPCCs to hypo-, normo- and hyperglycemic culture media for ~3 wee

135 ase from cerebral microvessels isolated from hypo-, normo- and hyperkalemic rats (2.3+/-0.1, 3.9+/-0.

136 poglycemia (2.8 +/- 0.1 mmol/l; n = 12; ANTE HYPO), or 4) hyperinsulinemic hypoglycemia (2.8 +/- 0.1

137 fic pathomechanisms, manifesting as either a hypo- or a hypercontractile phenotype, suggesting ration

138 6% of the mutations screened as putative FSC hypo- or hyper-competitors, respectively.

139 brain throughout the diurnal cycle, even in hypo- or hyper-glycemia.

140 ep output of each locus being either equal-, hypo- or hyper-methylated locus without further post-hoc

141 The hypo- or hyper-methylation of the human genome is one of

142 , tissue specific information in the form of hypo- or hyper-methylation.

143 with alanine (9A) or aspartate (9D) to mimic hypo- or hyper-phosphorylation, respectively.

144 ivo environment, certain cell subsets became hypo- or hyper-responsive, showed profound differences i

145 efault mode network, but the directionality (hypo- or hyper-RSFC) differed across factors.

146 iveness and through this mechanism intrinsic hypo- or hyperactive adrenal medullas in some individual

147 levels of trachea displacement under either hypo- or hypercapnic conditions.

148 , whereas chronic infection can cause either hypo- or hyperchlorhydria, depending on the distribution

149 Whether these neuroadaptations lead to a hypo- or hyperdopaminergic state during abstinence is a

150 entifying an underlying cause and correcting hypo- or hyperfunction of an endocrine gland, however, c

151 locorticoid bioactivity in patients who have hypo- or hyperkalemia.

152 ose that the methylation pattern and status (hypo- or hypermethylation) of genomic DNA may determine

153 Hypo- or hypermethylation-mediated oncogene activation,

154 ontent, are common and ascertained by plasma hypo- or hypernatremia, respectively.

155 slices were exposed to different degrees of hypo- or hyperosmolality 15 min prior to and during a 15

156 red, leaving patients vulnerable to cerebral hypo- or hyperperfusion.

157 Cells with either hypo- or hyperphosphorylation of DNA-PKcs at these sites

158 re induced by early drug exposure, producing hypo- or hyperresponsiveness to environmental or pharmac

159 physiology, we also examined the effects of hypo- or hypertension, and the impact of decreased hydra

160 management have been hampered by deleterious hypo- or hyperthermia caused by TRPV1 agonists/antagonis

161 Individuals with hypo- or hyperthyroidism showed various changes in elect

162 ysis comparing participants with subclinical hypo- or hyperthyroidism versus euthyroidism, adjusting

163 uggable targets for therapeutic treatment of hypo- or hyperthyroidism.

164 )-diabetic (diabetic), and STZ-diabetic kept hypo- or normoglycemic with insulin pellets (diabetic-no

165 n (antecedent hypoglycemia without miglitol [HYPO]) or with miglitol infused upstream in the PMV, per

166 and increased by 0.32 0.27 l kg(-1) in group Hypo (P = 0.030).

167 ce (all P <= 0.048), but not lower CVR(HYPER/HYPO) (P >= 0.26).

168 mance (all P 0.048), but not lower CVR(HYPER/HYPO) (P 0.26).

169 esent investigation, Tregs derived from CD18(hypo) PL/J mice were analyzed for their propensity to di

170 23/p19 depletion, injection of diseased CD18(hypo) PL/J mice with anti-gammadeltaTCR Abs significantl

171 the psoriasiform dermatitis observed in CD18(hypo) PL/J mice.

172 In the CD18(hypo) PL/J mouse model of psoriasis, reduced expression

173 Severity of CD18(hypo) PL/J psoriasiform dermatitis correlated with a los

174 Using the polygenic CD18(hypo) PL/J psoriasis mouse model spontaneously developin

175 Adoptively transferred CD18(hypo) PL/J Tregs were more inclined toward conversion in

176 t manner similar to conversion rates of CD18(hypo) PL/J Tregs.

177 ypercapnia (CVR(HYPER) ) and hypocapnia (CVR(HYPO) ), respectively.

178 in whether recurrent nonsevere hypoglycemia (Hypo) results in long-term cognitive impairment in type

179 The depressed brain was characterized by a "hypo" state, that included downregulation of activity-re

180 ntinuous, preimplantation) and temperatures (hypo-, sub, or normothermic).

181 During 2VO+Hypo, the EEG became isoelectric in all animals.

182 Consistent with this hypo- thesis, the ATPgammaS effects were both time- and

183 tidepressant dosing results in a switch from hypo- to hyper-cortical activity that arises as a conseq

184 c regions, and (3) sporadic transitions from hypo- to hypermethylated equilibria as a result of methy

185 hosphorylation of PERIOD (PER) proteins from hypo- to hyperphosphorylated species, events that are hi

186 This transition from hypo- to hyperproliferation presents an intriguing parad

187 ons were small, homogeneously enhancing, and hypo- to isointense on T1-weighted images and iso- to sl

188 Baseline CVR(HYPER/HYPO) values were strongly associated with their indomet

189 the basis of cholesterol absorption status (hypo- versus hyperabsorbers) or cholesterol synthesis st

190 The dichotomy between the hypo- versus hyperkinetic nature of Parkinson's disease

191 rabsorbers) or cholesterol synthesis status (hypo- versus hypersynthesizers) did not alter these resu

192 mice (Control and Nrf2(-/-) +/- T1D and +/- Hypo) were subject to recurrent, twice-weekly, insulin o

193 tty acid metabolism, and purine metabolism [(hypo) xanthine/inosine-containing pathways].

194 ied using Z-scores of LGI (hyper: Z >= 2.58, hypo: Z <= - 2.58).