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1 t ventral branch migration in the breathless hypomorph.
2 issue polarity as it is deleted in a weak fy hypomorph.
3 supported by hypersensitivity against a gyrA hypomorph.
4  increased circulating catecholamines in the hypomorph.
5 r organization of GlyRs is preserved in this hypomorph.
6 P1 expression and therefore generated a NRP1 hypomorph.
7 s shown by mig-38 RNAi with the mig-15(rh80) hypomorph.
8 xpression pattern using heterozygosity and a hypomorph.
9 ng partner Csk, unmasks the risk allele as a hypomorph.
10 was compromised in neurons cultured from the hypomorphs.
11 equency of vascular defects reported in Fgf8 hypomorphs.
12 solated new vn mutations including nulls and hypomorphs.
13 ising from the G843D mutation and other PEX1 hypomorphs.
14 e in inflammatory cytokine expression in the hypomorphs.
15  We term such host proteins as viral-induced hypomorphs.
16 crepancies between receptor mutants and Ntn1 hypomorphs.
17  for persistent attraction to the midline in hypomorphs.
18 um channel are markedly increased in the 10% hypomorphs.
19 d this phosphorylation is compromised in CK2 hypomorphs.
20  source of lethality in irradiated Smc5-Smc6 hypomorphs.
21 -associated Six3 mutant proteins function as hypomorphs.
22 ation when breaks are reduced in yeast spo11 hypomorphs.
23 proach was used to generate a series of Plk1 hypomorphs.
24 nstrated by the myeloerythroid bias in Dnmt1 hypomorphs, a comprehensive DNA methylation map of haema
25 permorphs at age 12 wk to 400% normal in the hypomorphs accompanied with proportionate changes in pla
26 and male reproductive tract, but served as a hypomorph allele in the development of the appendicular
27 onsistent with reported phenotypes of Trip13 hypomorph alleles.
28 bly, the reduced Elmo1 expression in the 30% hypomorphs almost abolishes the pathological features of
29 y defects, the mutant protein is both a mild hypomorph and a potent antimorph as determined by the ef
30                We have combined Twist1 null, hypomorph and conditional alleles to generate a Twist1 a
31                               Homozygous Sno hypomorph and null mutant mice are viable without gross
32 idence that the aphakia allele of Pitx3 is a hypomorph and that Pitx3 is required for the regulation
33 is indicated protein-coding alterations in 8 hypomorphs and 6 amorphs, with mild-moderate phenotypes
34 , moderate, umbrous-like, severe) for the 18 hypomorphs and a single category for the 7 amorphs (null
35 penetrance of mutant phenotypes in signaling hypomorphs and explains available experiments with no ad
36 veal or mask the increased variation in ltp2 hypomorphs and found that increased expression of its cl
37                                        Vegfa hypomorphs and isoform-specific (medium/long) morphants
38 ison of the mutant phenotypes of dpp and gbb hypomorphs and null clones shows that both BMPs act loca
39                                          Ten hypomorphs and one null demonstrated wild-type coding po
40  homozygous lethal in midgestation, but Mpc1 hypomorphs and tissue-specific deletion of Mpc1 presente
41 eed to better understand the behavior of p53 hypomorphs and to develop a functional assay that can di
42 s stages up through metamorphosis (synthetic hypomorphs) and displayed prepupal and pupal phenotypes
43 us: a 5' deletion, with reduced Sno protein (hypomorph), and an exon 1 deletion removing half the pro
44                    The kcc(DHS1) allele is a hypomorph, and its seizure-like phenotype reflects reduc
45 ies: inactivation of tumor suppressor genes (hypomorph, antimorph or amorph) or activation of oncogen
46 phs showed only slight G2/M arrest, a medium hypomorph arrested with 4N DNA content, followed later b
47                       It was deduced to be a hypomorph, as Pax3 protein expression is reduced by 80%
48 NA-mediated silencing to generate epiallelic hypomorphs associated with KIF14 depletion.
49 xpression may be systemically and reversibly hypomorphed at will, we asked whether this resistance to
50 icant improvement in serum creatinine in the hypomorphs at 3 and 10 days after injury, and renal fibr
51 TP1, NQO1) revealed higher expression in the hypomorphs at baseline.
52 otes but also partially complement other dpp hypomorphs at low temperatures.
53 uppress the DNA damage sensitivity of Smc5/6 hypomorphs but not that of HR mutants and remarkably dec
54 ro, suggesting that the mutants are actually hypomorphs, but must be above certain concentration to e
55 dated peptides were largely absent in strong hypomorphs, but peptide precursors, a nonamidated neurop
56 rescue of the innervation phenotype of FasII hypomorphs by over expressing FasII in glia.
57 e findings demonstrate that an Mcm2(Cre/Cre) hypomorph can induce hematopoietic dysfunction via hemat
58  Similarly, SL interactions of viral-induced hypomorphs can potentially be targeted as host-based ant
59  A p53 mutant at this site (Y327F) acts as a hypomorph, causing an attenuated p53-mediated transcript
60 ve previously reported generation of an Orc2 hypomorph cell line (Delta/-) that expresses very low le
61  genetically disrupted for DNMT1 (DNMT1(-/-) hypomorph cells).
62                         The Eya1(bor) mutant hypomorph contains an intracisternal A particle insertio
63 ional exposure, the patent DV in AHR or ARNT hypomorphs could be efficiently closed by dioxin exposur
64  expression is reduced by 80% and homozygote hypomorphs die postnatally.
65 scued by L. major glf, which behave as glf-1 hypomorphs, display resistance to infection by Microbact
66                A global reduction of Fgf8 in hypomorph embryos leads to an early loss of placode-deri
67                                     In JIL-1 hypomorphs, euchromatic regions of polytene chromosomes
68       Diabetic Sco2 (KO/KI) and Sco2 (KI/KI) hypomorphs exhibited a reduction in complex IV activity,
69             Diabetic Sco2KO/KI and Sco2KI/KI hypomorphs exhibited a reduction in complex IV activity,
70  toxicity studies demonstrated that the ARNT hypomorphs exhibited resistance to the end points of dio
71 inked to pseudopod extension, whereas a PTEN hypomorph exhibits elevated RacB activation.
72                                      In Nav2 hypomorphs, fewer granule cells migrate out of cerebella
73  function and that Tgfb1(C33S/C33S) mice are hypomorphs for active TGF-beta1.
74 elop a functional assay that can distinguish hypomorphs from wild-type p53 or benign variants.
75                              While the HSP82 hypomorph grows normally in vitro at 37 degrees C and un
76                             The diabetic 10% hypomorphs had comparable creatinine clearance and album
77 tudy of the transcriptional targets of these hypomorphs has the potential to reveal the identity of o
78  which we believe is either a null or severe hypomorph, has an IRES-lacZ-neomycin resistance cassette
79 ver perfusion studies demonstrated that ARNT hypomorphs have a patent ductus venosus, identical to th
80                             Foxc1 homozygous hypomorphs have CVH with medial fusion and foliation def
81                                         Fgf8 hypomorphs have hypoplastic SMGs, whereas conditional mu
82                 Here we show that alpha-SNAP hypomorph, hydrocephalus with hopping gait, Napa(hyh/hyh
83                                    As in the hypomorph, IFE proliferation was stimulated and expressi
84 ng variants in AKI we tested a mouse Tnfaip3 hypomorph in a model of ischemia reperfusion injury (IRI
85 e in rates of somatic 11q deletion, and is a hypomorph in cell-based assays.
86 nduced expression of the orthologous Delta10 hypomorph in triple transgenic Pdgfralpha-Cre/ERT; R26-S
87                   This also occurs in Smc5/6 hypomorphs in the fission yeast Schizosaccharomyces pomb
88 in vitro and results in striking Hh gradient hypomorphs in vivo.
89                Altered phenotypes in the NR1 hypomorphs include marked deficits in species-typical be
90 ssion from low to high in the tubules of the hypomorphs increased their albumin excretion more than 1
91 emonstrates its partial attenuation in Tex14 hypomorphs, indicating that intercellular bridges enable
92 ion and dMYC-dependent overgrowth in the Hfp hypomorph is further impaired in the C-terminal Hay/XPB
93 The altered phenotypic landscape in our adar hypomorph is paralleled by an unexpected dichotomous res
94 ean number of supercoil domains, this gyrase hypomorph is prone to fork collapse and topological chao
95                  The hypertension in the 10% hypomorphs is corrected by spironolactone or amiloride a
96           Characterization of the SV40 miRNA hypomorph, K661, shows that it is inhibited at the early
97                                          blp hypomorph larvae had a 35% decreased number of plasmatoc
98 s LDH-A and rescue expression of a catalytic hypomorph LDH-A mutant, Y10F, demonstrate increased resp
99 showed that the BALB/c allele of Ube2l6 is a hypomorph leading to the lack of UBE2L6 protein expressi
100              They further establish the SOCE hypomorph line as a genetic model to define the therapeu
101                                          The hypomorph mice are viable and fertile, with no overt def
102  decreased after SCI in Becn1(+/-) autophagy hypomorph mice compared to wild-type (WT) controls.
103                                         SOCE hypomorph mice develop and reproduce normally and do not
104 hat B. burgdorferi-infected hearts from CD18 hypomorph mice express increased levels of MCP-1 RNA com
105                                         CD18 hypomorph mice expressing reduced levels of the common b
106                                              Hypomorph mice have similar susceptibility to controls t
107  increased severity of Lyme carditis in CD18 hypomorph mice is caused by deficiency in CD11a or CD11c
108                        Decreased SOCE in the hypomorph mice is due to poor translocation of the mutan
109 e demonstrate that dendritic cells from CD18 hypomorph mice secrete higher levels of monocyte/macroph
110                 B. burgdorferi-infected CD18 hypomorph mice showed an increased macrophage infiltrati
111                   Additionally, male Slc39a8 hypomorph mice showed greater overall nicotine preferenc
112                              In Trip13(Gt/Gt)hypomorph mice treated with unilateral renal IRI, persis
113                            Similarly to CD18 hypomorph mice, CD11c-/- mice expressed higher levels of
114 the beta2 integrins was investigated in CD18 hypomorph mice, which express low levels of CD18.
115                       We have created a Dazl hypomorph model using short interfering RNA knockdown in
116 loxed stromal interaction molecule 1 (STIM1) hypomorph mouse model was generated with significant red
117                                    In a Dll1 hypomorph mutant that survives until birth, hair follicl
118 model to compare the phenotypes of an EBNA3A hypomorph mutant virus (Delta3A) and wild-type EBV.
119  ENU mutagenesis screen and generated a Brg1 hypomorph mutation in the ATPase domain.
120                                              Hypomorph mutations in sld3 are suppressed by a mcm4 reg
121       Here, we identify COII(G177S), a mtDNA hypomorph of cytochrome oxidase II, which specifically i
122 anscription of Sema3c in the OFT, whereas, a hypomorph of Tbx1, a key SHF transcription factor, resul
123              The Hoxb2 mutant phenotype is a hypomorph of the Hoxb1 mutant phenotype, consistent with
124 g that two different African-centric genetic hypomorphs of p53 that occur in distinct functional doma
125 raits in Arabidopsis thaliana, we found that hypomorphs of the cuticle-related gene LIPID TRANSFER PR
126 imilar to defects observed in knock-outs and hypomorphs of the Notch ligand Serrate-2.
127 R localization in metaphase-II Mater(tm/tm) (hypomorph) oocytes and found ER clusters to be less abun
128  CNOT1 variants are likely haploinsufficient hypomorph or neomorph, rather than dominant negative.
129 sting, the combined OR associated with BRIP1 hypomorph or null missense carriers compared with the ge
130  characterized variants rendered the protein hypomorph or null.
131 on of a Seckel syndrome patient-derived DNA2 hypomorph or partial degradation of DNA2, providing a co
132 engths are reduced to varying degrees in MRN hypomorphs or if MRE11 nuclease activity is attenuated i
133                                         Dazl hypomorph ovaries had a phenotype of impaired germ cell
134 ion by three different cancer-associated p53 hypomorphs: P47S (Pro47Ser, rs1800371), Y107H (Tyr107His
135 sion of phosphorylation-deficient, catalytic hypomorph PDHK1 mutants in cancer cells leads to decreas
136 ons, showing that MLL translocations cause a hypomorph phenotype of RUNX1/CBFbeta.
137 s-oriented combination of minor, potentially hypomorph-producing alleles at common variant sites plus
138  Orai1 gene-trap mutant mouse which may be a hypomorph rather than a true null.
139 tinct from RAG nullizygosity, the RAG1-S723C hypomorph results in aberrant DNA double-strand breaks w
140                    Natural and synthetic PHM hypomorphs revealed phenotypes that resembled those of a
141               RNA interference targeting Rac hypomorphs revealed synergistic interactions between the
142 otype induced in the PV myocardium in Nkx2-5 hypomorphs reverted back to a working myocardial phenoty
143    Here, we investigated the effects of Sco2 hypomorphs (Sco2 (KO/KI) , Sco2 (KI/KI) ), with a functi
144    Here, we investigated the effects of Sco2 hypomorphs (Sco2KO/KI, Sco2KI/KI), with a functional los
145 en particularly well studied in knockout and hypomorph settings as well as models recapitulating the
146                      In HeLa cells, two weak hypomorphs showed only slight G2/M arrest, a medium hypo
147                              We found that 4 hypomorphs significantly reduced MMS to varying degrees.
148 common UNC45B variant that acts as a complex hypomorph splice variant.
149 hibitory concentration (MIC) against a mmpL3 hypomorph, suggesting mutations in MmpL3 as a possible r
150 posis Coli 2 (APC2) rescued GSC loss in chic hypomorphs, suggesting an additive role of APC2 and F-ac
151 pression was attenuated or reversed in Keap1 hypomorphs, suggesting that protection in these mice was
152 throid maturation was deficient in these Scl hypomorphs, supporting that Scl was required both for th
153  passenger complex (CPC), AURKC p.C229Y is a hypomorph that cannot fully support cell-cycle progressi
154 an N-terminal GFP-Foxp3 fusion protein, is a hypomorph that causes profoundly accelerated autoimmune
155 , with NPC1, we have generated a murine NPC2 hypomorph that expresses 0-4% residual protein in differ
156                              One allele is a hypomorph that generates less protein and exhibits struc
157  Thus, viral protein interactions can induce hypomorphs that render host cells selectively vulnerable
158                                    In Fas II hypomorphs, the number of contact points is increased, a
159                 Consequently, we used a BMP4 hypomorph to investigate the role of BMP4 in regulating
160 to better understand the contribution of p53 hypomorphs to disease risk and should help better inform
161 lizability of our findings, we subjected the hypomorphs to unilateral ureteral obstruction (UUO) and
162 genetic model of brd2 lo mice, a BET protein hypomorph, to show that Brd2 is essential for proinflamm
163 sporter SLC6A6 was identified resulting in a hypomorph transporting capacity of ~15% compared with no
164 llowed later by apoptosis, and a strong Plk1 hypomorph underwent serious mitotic catastrophe.
165                               GBF1 becomes a hypomorph upon interaction with the poliovirus protein 3
166 ion defect of a smk1-2 temperature-sensitive hypomorph were isolated.
167 mRNA enhances the Daf-c phenotype of a daf-4 hypomorph, whereas the same transgene with a nonsense mu
168 the 300% hypermorphs to six times in the 10% hypomorphs, which have elevated blood pressure.
169 ng, resulting in the overexpression of BRCA1 hypomorphs, which in turn promote PARPi resistance.
170 strongly enhanced phenotype relative to Ntn1 hypomorphs, which retain many axons with normal trajecto
171                     Here we utilized a Tex14 hypomorph with reduced intercellular bridges along with
172 e-trap mouse (Pikfyve(beta-geo/beta-geo)), a hypomorph with ~10% of the normal level of Pikfyve prote
173 amage, since the synthetic lethality of smc6 hypomorphs with a topoisomerase II mutant, defective in
174 ssue using a novel genetic mouse model (SOCE hypomorph) with deficient SOCE, nuclear factor of activa
175 ectrolytes are markedly decreased in the 10% hypomorphs without significant change in the glomerular

 
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