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1 (cleft palate, cleft lip, anal atresia, and hypospadias).
2 be the best approach for midshaft and distal hypospadias.
3 m a completely female appearance to isolated hypospadias.
4 hat included vaginal and uterine defects and hypospadias.
5 anomalies, especially cryptorchidism and/or hypospadias.
6 co-occurring CHD compared with boys without hypospadias.
7 Leydig cell hypoplasia, cryptorchidism, and hypospadias.
8 higher prevalence of CHDs than boys without hypospadias.
9 al CHD screening programs for boys born with hypospadias.
10 rmation and potential implications for human hypospadias.
11 cellent outcomes for distal but not proximal hypospadias.
12 ween placental weight and cryptorchidism and hypospadias.
13 re older (p = 0.048) compared with boys with hypospadias.
14 , all of which have been implicated in human hypospadias.
15 ght into possible genetic mechanisms causing hypospadias.
16 such as cryptorchidism, urethral defects and hypospadias.
17 e-scale analysis of phytoestrogen intake and hypospadias.
18 sures to estrogenic compounds impact risk of hypospadias.
19 lies cryptorchidism (undescended testis) and hypospadias.
20 st relevant tissue sample available to study hypospadias.
21 yndrome disorders, namely cryptorchidism and hypospadias.
22 tween chlordane levels and cryptorchidism or hypospadias.
23 ion during the external genital phase causes hypospadias.
24 rgets the developing penis in utero to cause hypospadias.
25 tract, including digit loss, syndactyly, and hypospadias.
26 wth factor receptor 2 (Fgfr2) exhibit severe hypospadias.
27 (1.9%), breast mass (1.2%), club foot (1%), hypospadias (0.6%), hydrocephalus (0.6%), cleft lip or p
28 eo-oesophageal anomalies (2.25 [0.96-5.26]), hypospadias (1.96 [0.98-3.92]), and gastroschisis (3.19
33 ng follow-up, 1,713 boys were diagnosed with hypospadias and 6,878 with cryptorchidism (3,624 underwe
36 Ablation of Nr5a1(+) cells leads to severe hypospadias and alters cell differentiation in the penis
37 ow window of prenatal development results in hypospadias and chordee, whereas earlier disruptions cau
39 g window did blocking androgen action induce hypospadias and cryptorchidism and altered penile length
42 sduce develop with variably penetrant severe hypospadias and incomplete midline fusion of the primiti
43 types: endodermal Fgfr2 deletion causes mild hypospadias and inhibits maturation of a complex urethra
44 dation, microcephaly, digital abnormalities, hypospadias and loose connective tissue) and resemble on
45 s in select reproductive organs (e.g. penile hypospadias and prostate dysgenesis but normal testis),
47 developmental link between Hoxa13-associated hypospadias and those produced by antagonists to androge
48 h hypospadias and so-called 'chordee without hypospadias', and so its correction is a topic of releva
50 crypt-orchidism, 1.2 (95% CI: 0.6, 2.4) for hypospadias, and 1.9 (95% CI: 0.9, 4.0) for polythelia.
52 7,20-lyase deficiency, including micropenis, hypospadias, and gynecomastia, who is homozygous for CYP
53 irth, the 46,XY proband had a bifid scrotum, hypospadias, and micropenis consistent with clinical sta
57 ascular injury in hypogonadism, and identify hypospadias as a cardiovascular risk factor in males.
59 ratio, 2.7; 95% CI, 1.4-5.3), and boys with hypospadias born to Hispanic mothers in Texas were 1.5 t
61 sm were longer than mean values in boys with hypospadias (both p < 0.01) and shorter than mean values
62 al defect characterized by hypertelorism and hypospadias, but additional midline malformations are al
63 developmental factors in the development of hypospadias, but there is doubt whether the incidence of
64 e analysis included data on mothers of 1,250 hypospadias cases and 3,118 controls who delivered their
66 s 15.7% lower beta-value at cg14436889 among hypospadias cases than controls (EWAS P = 5.4e-7) and is
68 tissue we identified 25 CpGs associated with hypospadias characteristics and used one-sample two stag
70 ed with many common birth defects, including hypospadias, cleft lip with or without cleft palate, or
72 s identified as a candidate gene involved in hypospadias, cryptorchidism and other genitourinary (GU)
74 reproductive tract abnormalities (including hypospadias, cryptorchidism, hypospermatogenesis, and te
76 en external urogenital and anorectal tracts; hypospadias - ectopic ventral positioning of the urethra
77 of a small utricle (not in the patient with hypospadias), ejaculatory duct reflux, internal urachal
78 the British Pediatric Association coding for hypospadias (exposure) and major CHDs (primary outcomes)
79 rgical techniques for treating patients with hypospadias, exstrophy, incontinence, and ambiguous or v
83 52, 95% confidence interval: 1.31, 1.76) and hypospadias (hazard ratio = 1.97, 95% confidence interva
84 deletion of Fgfr2 results in the most severe hypospadias highlights a major role for Fgfr2 in the dev
85 mass, obstetric fistula, undescended testes, hypospadias, hydrocephalus, cleft lip or palate, and clu
86 ses, obstetric fistulas, undescended testes, hypospadias, hydrocephalus, cleft lip/palate, and clubfo
89 beta-catenin knockout animals develop severe hypospadias in both sexes raises the possibility that th
91 Fgfr2 or its ligand Fgf10 results in severe hypospadias in mice, in which the entire urethral plate
92 nor abnormalities at or shortly after birth (hypospadias in one baby and rotation of small intestine
93 7.024% (95% CI, 7.020%-7.028%) of boys with hypospadias in Texas and 5.503% (95% CI, 5.495%-5.511%)
94 ospadias repair, especially that of proximal hypospadias (in which reconstruction of a long urethra i
96 patient presented with developmental delay, hypospadias, inguinal hernia and dysmorphic features whi
97 cele [adult and paediatric]), hydrocephalus, hypospadias, injuries or wounds, neck mass, undescended
106 ate of hypogonadism, we investigated whether hypospadias is associated with vascular dysfunction and
108 of FK506-binding protein-52 (Fkbp52) develop hypospadias, most likely due to actions of Fkbp52 as a m
109 d adjusted odds of cryptorchidism (n = 219), hypospadias (n = 199), and polythelia (extra nipples) (n
110 chidism (n = 71, age 13.4 +/- 5.8 months) or hypospadias (n = 81, age 11.4 +/- 6.2 months) were recru
112 every specific CHD analyzed among boys with hypospadias, occurred outside of chromosomal anomalies,
114 and penile length were reduced in boys with hypospadias or cryptorchidism relative to normative data
115 rders of fetal masculinization, resulting in hypospadias or cryptorchidism, are common, but their cau
116 nce, is susceptible to birth defects such as hypospadias or incomplete closure of urethra along the p
119 expression in the urethra, and an associated hypospadias phenotype, suggesting that these genes are d
120 loss of estrogen signaling results in a mild hypospadias phenotype, the most common manifestation of
121 The use of engineered tissue substitutes in hypospadias reconstruction has also been applied clinica
122 e risk for co-occurring CHDs among boys with hypospadias remains unknown, which limits screening and
123 teries from penile skin from boys undergoing hypospadias repair and controls were isolated and functi
124 as challenged more traditional approaches to hypospadias repair and is now considered by many pediatr
128 After more than 100 years of innovation in hypospadias repair, new concepts regarding penile curvat
131 quartile-specific ORs for cryptorchidism or hypospadias show no notable associations with trans-nona
135 le to simplify decision-making algorithms in hypospadias surgery, while achieving good functional and
138 pendently associated with the likelihood for hypospadias to co-occur with a CHD; boys in Texas with t
139 exhibit genital anomalies, which range from hypospadias to complete male-to-female sex reversal.
140 3.4) more likely than boys with first-degree hypospadias to have a co-occurring CHD, with consistent
141 cial support with risks of gastroschisis and hypospadias, using data from the National Birth Defects
142 in the bladder wall; affected males may have hypospadias (ventrally misplaced urethral opening) of va
144 in Texas with third-degree (ie, more severe) hypospadias were 2.7 times (95% CI, 2.2-3.4) more likely
149 AGD in human infants with cryptorchidism and hypospadias, which are potential manifestations of TDS d
150 surgical techniques have been developed for hypospadias, with excellent outcomes for distal but not