ライフサイエンスコーパス: hypotension

1 ental benefit or raised safety concerns (ie, hypotension).

2 arm could not complete the trial because of hypotension.

3 a decrease in the frequency of intradialytic hypotension.

4 creased shunting at the expense of worsening hypotension.

5 The primary outcome was post-intubation hypotension.

6 least 95 mm Hg, and no signs or symptoms of hypotension.

7 l, 24% of patients developed post-intubation hypotension.

8 es, such as vasovagal syncope or orthostatic hypotension.

9 mes depended on the amount of intraoperative hypotension.

10 nd placebo-propofol groups (24% and 23%) had hypotension.

11 y higher rates of cardiovascular disease and hypotension.

12 een oxygen demand and supply, as with severe hypotension.

13 atheter ablation for AF but resulted in more hypotension.

14 erized by higher inflammatory biomarkers and hypotension.

15 tial loss-of-function PLD2 polymorphism with hypotension.

16 anaphylaxis could prevent the development of hypotension.

17 dently associated with acetaminophen-induced hypotension.

18 cific transient abdominal pain and transient hypotension.

19 nditions of severe hemolysis after prolonged hypotension.

20 Toxicities included fever, tachycardia, and hypotension.

21 risk of developing in-hospital occurrence of hypotension.

22 One subject had evidence of orthostatic hypotension.

23 d surgical factors-and perhaps postoperative hypotension.

24 Anaphylactic shock is associated with severe hypotension.

25 ssess the incidence of acetaminophen-induced hypotension.

26 tandard care resulted in less intraoperative hypotension.

27 emodialysis may have contributed to systemic hypotension.

28 mediate administration in the event of acute hypotension.

29 GRE2, causing localized hives, flushing, and hypotension.

30 vascular dilation, vascular permeability and hypotension.

31 emodialysis may have contributed to systemic hypotension.

32 esthetic concentration, EEG suppression, and hypotension.

33 s an alpha1-agonist approved for orthostatic hypotension.

34 lead to side effects, for instance systemic hypotension.

35 g with end-organ dysfunction ascribed to the hypotension.

36 rolled 310 adults diagnosed with sepsis with hypotension.

37 Rates of adverse events including hypotension (1.7% vs 3.9%) were similar in both groups.

38 < 0.05) higher rates of DGF, 32% versus 19%; hypotension, 14% versus 4%; acute myocardial infarction,

39 Hypotension (1615 [40%] patients) and dehydration (1536

40 The most frequent adverse events were hypotension (17.6%), dizziness (16.8%), hyperkalemia (13

41 hemorrhagic bullae 25.2% and 95.8%, and for hypotension 21.0% and 97.7%.

42 es of data, such as excluding the absence of hypotension (276 of 491 policies [56.2%]) and hypothermi

43 Among patients with acetaminophen-induced hypotension, 29 (34.9%) required therapeutic interventio

44 o 56 100 (95% CI, 50 800-61 400) episodes of hypotension, 34 400 (95% CI, 31 200-37 600) episodes of

45 re hypoxemia (55 of 610 patients [9.0%]) and hypotension (39 of 610 patients [6.4%]) in the rocuroniu

46 than that of patients who did not experience hypotension (496 min vs 253 min, P = 0.000).

47 The prevalence of hypotension (57% vs 48%), atrial fibrillation (50% vs 40

48 m group and hypoxemia (61 of 616 [9.9%]) and hypotension (62 of 616 patients [10.1%]) in the succinyl

49 he (26% vs 10%), dizziness (15% vs 10%), and hypotension (8% vs 2%).

50 There were more dizziness (9.9% vs 1.1%), hypotension (8.8% vs 0%), and headache (11% vs 6.7%) TEA

51 improve mortality in AKI patients, although hypotension accompanied by pGC-A activators have limited

52 ts (51.9%) experienced acetaminophen-induced hypotension according to our definition.

53 e and baseline heart failure, renal failure, hypotension, acute kidney injury, altered gas exchange,

54 rchloremic metabolic acidosis, inflammation, hypotension, acute kidney injury, and death.

55 participants with sepsis, organ dysfunction (hypotension, acute respiratory failure, and/or acute ren

56 score), patient age, prehospital or arrival hypotension, admission from a long-term care facility, m

57 hange in space (accompanied by mild relative hypotension), all of which returned to preflight values

58 hreatening kidney disease featuring arterial hypotension along with electrolyte abnormalities.

59 shift >=5 mm), presence of hypoxia, systemic hypotension, altitude higher than >500 m, and GDP per ca

60 ulting in monogenic forms of hypertension or hypotension and >1,477 common single-nucleotide polymorp

61 sought to determine the relationship between hypotension and a composite of myocardial injury (tropon

62 0 mL/kg of blood was removed yielding marked hypotension and a rise in plasma lactate.

63 were substratified by whether they developed hypotension and acute kidney injury (AKI) during the ind

64 exploring the relationship between relative hypotension and adverse kidney-related outcomes among cr

65 llow up discontinued NSBB, most commonly for hypotension and AKI, had increased subsequent MELD and m

66 Of these, hypotension and atrial fibrillation were assessed by inv

67 vity, which is augmented under conditions of hypotension and autonomic dysfunction.

68 Occurrence of hypotension and bradycardia did not differ between group

69 Hypotension and changes in fluid-electrolyte balance pos

70 to two groups according to the occurrence of hypotension and compared demographic characteristics, cl

71 evere heart failure, which is accompanied by hypotension and cyanosis, pericardial effusion, low volt

72 dodrine is prescribed to prevent symptomatic hypotension and decrease complications associated with h

73 d cardiogenic shock, acutely manifested with hypotension and dyspnea.

74 n problematic, with development of prolonged hypotension and edema.

75 ETCO2 declined precipitously, followed by hypotension and EKG changes.

76 pressure was normal in the NA group; severe hypotension and high mortality were observed in controls

77 condition at admission with higher rates of hypotension and higher Injury Severity Score, when compa

78 shock (higher serum lactate level, combined hypotension and hyperlactatemia, or higher predicted ris

79 nable analysis of the role of these cells in hypotension and hypertension, and may suggest novel ther

80 sults in other physiological effects such as hypotension and hypothermia.

81 athy in humans, is characterized by systemic hypotension and impaired macrovascular and microvascular

82 Numerically more episodes of hypotension and intubation occurred in the fosphenytoin

83 hypoxic episodes because of lung immaturity, hypotension and lack of cerebral-flow regulation, and ca

84 observed that S1P administration ameliorated hypotension and microvascular leakage following combined

85 hemorrhagic shock and resuscitation-induced hypotension and microvascular leakage.

86 Most of the patients (17) also had hypotension and needed vasopressors.

87 ses showed that the relationship between ICU hypotension and outcomes depended on the amount of intra

88 the renal graft (DGF), which can result from hypotension and pressor use related to the liver transpl

89 blood volume hemorrhage to achieve profound hypotension and shock.

90 Neurogenic orthostatic hypotension and supine hypertension are common manifesta

91 ients with coexistent neurogenic orthostatic hypotension and supine hypertension, clinicians need to

92 ients with coexistent neurogenic orthostatic hypotension and supine hypertension.

93 ients with coexistent neurogenic orthostatic hypotension and supine hypertension; and the prevalence,

94 fits of treatment for neurogenic orthostatic hypotension and the long-term risks of supine hypertensi

95 There was no association between duration of hypotension and time to discharge.

96 It results in hypotension and tissue edema and contributes to organ dy

97 cell toxicities, with early intervention for hypotension and treatment of concurrent infections being

98 part of the vasopressor system that induces hypotension and vasodilation and is degraded by ACE and

99 uma, hypertension in midlife and orthostatic hypotension) and 9 with Level B weaker evidence (obesity

100 r chest injury, and admission heart rate and hypotension) and year, transfer status, and facility tra

101 Nine patients experienced hypotension, and 5 had elevated serum aminotransferases,

102 (VSMCs) led to reduced arterial elasticity, hypotension, and an impaired arterial response to angiot

103 ng renal function, hyperkalemia, symptomatic hypotension, and angioedema did not differ significantly

104 ng renal function, hyperkalemia, symptomatic hypotension, and angioedema did not differ significantly

105 ng renal function, hyperkalemia, symptomatic hypotension, and angioedema.

106 of the consequences of acetaminophen-induced hypotension, and assess the pathophysiologic mechanisms

107 ncluded symptomatic bradycardia, symptomatic hypotension, and cardiogenic shock.

108 h cytokine-release syndrome including fever, hypotension, and dyspnea.

109 side effects such as peripheral neuropathy, hypotension, and hypersensitivity.

110 and renal failure, with absence of fever or hypotension, and in inpatient-presenting sepsis.

111 downregulation, vascular hypocontractility, hypotension, and mortality.

112 Prevention (CDC; fever, rash, desquamation, hypotension, and multi-system involvement) as well as a

113 diabetes, coronary heart disease, migraine, hypotension, and obstructive sleep apnea syndrome.

114 parameters, opioid consumption, incidence of hypotension, and patient satisfaction seemed to be in fa

115 orphine, midazolam), mechanical ventilation, hypotension, and surgeries.

116 ved IV injections of acetaminophen developed hypotension, and up to one third of the observed episode

117 ia, in comparison with postoperative status, hypotension, anemia, and hypoxia.

118 Hypotension appears to be a prominent risk factor.

119 f event in hospital, extracorporeal CPR, and hypotension as the cause of arrest), as well as variable

120 nts aged 65 years or older with vasodilatory hypotension (assessed by treating clinician).

121 pecial interest (haemoptysis and symptomatic hypotension), assessed in the intention-to-treat populat

122 achycardia/bradycardia at 33% (327/977), and hypotension at 27% (261/977) in the delayed group.

123 ascular or cerebrovascular disease, arterial hypotension at admission, and black or Latino ethnicity

124 Orthostatic hypotension, before or in the setting of more intensive

125 This was calculated as the depth of hypotension below a MAP of 65 mm Hg (in millimeters of m

126 e captures both the severity and duration of hypotension below a mean arterial pressure threshold and

127 min; CI, -159 to -125; p < 0.001), baseline hypotension (beta, -39 min; CI, -48 to -32; p < 0.001),

128 ty of life, cardiopulmonary morbidity (e.g., hypotension, bradycardia, bronchospasm, and/or congestiv

129 However, data regarding mitigation of hypotension by lowering dialysate temperature in patient

130 Intracranial hypotension can mimic other conditions such as aseptic m

131 ill adults and is frequently complicated by hypotension, cardiac arrest, or death.

132 experienced hemodynamic decompensation with hypotension, cardiogenic shock, or cardiac arrest.

133 ne group had a lower risk of post-intubation hypotension compared to the reference group (15% vs 29%,

134 days, 500 of 1221 (41.0%) in the permissive hypotension compared with 544 of 1242 (43.8%) in the usu

135 ors for vasodilatory hypotension, permissive hypotension compared with usual care did not result in a

136 rtality among Zambian adults with sepsis and hypotension compared with usual care.

137 efficacious for advance warning of impending hypotension, compared with a basic hypotension threshold

138 attern of midlife hypertension and late-life hypotension, compared with midlife and late-life normal

139 Hypotension compromises local tissue perfusion, thereby

140 dverse reactions related to study treatment (hypotension considered to be immediately life-threatenin

141 tonomic dysfunction, featured by orthostatic hypotension, constipation, hypohidrosis and hyposmia, wi

142 The degree of hypotension correlated with percentage of ArchT-transduc

143 Intradialytic cerebral ischemia, but not hypotension, correlated with decreased executive cogniti

144 Among prespecified adverse events, only hypotension (decline in systolic blood pressure of more

145 In sensitivity analyses hypotension defined as pressures less than 80 mm Hg and

146 Increasing amounts of hypotension (defined by lowest mean arterial pressures p

147 Intraoperative hypotension does not seem to be a clinically important p

148 Rationale: Cardiac involvement and hypotension dominate the prognosis of light-chain amyloi

149 limited by systemic adverse effects such as hypotension due to the importance of angiotensin signali

150 stronaut experienced orthostatic intolerance/hypotension during activities of daily living before or

151 n capture clinically significant orthostatic hypotension during activities of daily living, especiall

152 n and decrease complications associated with hypotension during dialysis.

153 primary outcome was time-weighted average of hypotension during surgery, with a unit of measure of mi

154 first presentation, 40 patients experienced hypotension during their ED stay.

155 ler dialysate experienced significantly less hypotension during treatment.

156 es: To investigate the magnitude of relative hypotension during vasopressor support among critically

157 A 56-year-old man who developed hypotension, dyspnea, hypoxia, and pulseless electrical

158 therapies are often limited by tolerability, hypotension, electrolyte disturbances, and renal dysfunc

159 dataset, 102-of-215 ICU stays experienced >1 hypotension episode (median of 2.5 episodes per day in t

160 es, we analyzed characteristics of sustained hypotension episodes (>15 min) and then developed a logi

161 loped a logistic regression model to predict hypotension episodes using input features related to BP

162 The most common serious toxicity was hypotension (escalation n=6 [40%], rotation n=5 [31%], c

163 Two major adverse events (hypotension event requiring vasopressor and continuous r

164 olus epinephrine was administered during 110 hypotension events in 77 patients (eight administrations

165 Adverse reactions (mainly hypotension, flushing, and hypokalemia) were self-limiti

166 radialytic exposure to cerebral ischemia and hypotension for each patient, and entered these values i

167 threshold of less than 90 mm Hg for treating hypotension for individuals 10 years and older based on

168 re injection site pain (four [4%] of 89) and hypotension (four [4%]) and the most common grade 3-4 ra

169 o identify condition at admission, including hypotension, Glasgow Coma Scale, mechanism and intent of

170 nd in the midlife hypertension and late-life hypotension group (HR, 1.62 [95% CI, 1.11-2.37]) had sig

171 Patients randomized to the permissive hypotension group had lower exposure to vasopressors com

172 The ED stay of the hypotension group was significantly longer than that of

173 ants with midlife hypertension and late-life hypotension had higher risk of mild cognitive impairment

174 esponses to physical stressors (for example, hypotension, hemorrhage and presence of lipopolysacchari

175 95% confidence interval (CI): 1.27 to 4.54), hypotension (HR: 1.87; 95% CI: 1.02 to 3.43), tachycardi

176 Infection, hypotension, hyponatremia, insomnia or stress, and benzo

177 , Injury Severity Score, Glasgow Coma Score, hypotension, hypoxia, and pupillary reactions between un

178 Intracranial hypotension (IH) is an uncommon, benign, and usually sel

179 Hypertension was present in 64 (65.3%), hypotension in 67 (68.4%), hyperglycemia in 17 (18.1%),

180 The immediate cause of arrest was hypotension in 67%, respiratory decompensation in 44%, a

181 Vasopressor infusion (VPI) is used to treat hypotension in an ICU.

182 ociated with a lower risk of post-intubation hypotension in hemodynamically-unstable patients in the

183 5 in UMICs vs 492 [39%] of 1260 in HICs) and hypotension in HICs (564 [45%] of 1260 vs 611 [38%%] of

184 myogenic vasoconstriction showed aggravated hypotension in response to endotoxin.

185 did not cause hypothermia (or bradycardia or hypotension) in QKO mice, indicating that AR-independent

186 adverse events (AEs) included hemorrhage or hypotension; incidence of common hemorrhagic AEs (includ

187 se norepinephrine in adults with sepsis with hypotension increases shock control by 6 hours compared

188 Perioperative hypotension is associated with an increase in postoperat

189 Intraoperative hypotension is associated with increased morbidity and m

190 shock and to determine whether such relative hypotension is associated with new significant acute kid

191 Because arterial hypotension is frequently a trigger for administering fl

192 Refractory hypotension is rare on admission but develops frequently

193 1 physical examination feature (eg, fever or hypotension) is not sufficient to rule-out NSTI.

194 greater than or equal to 55 years, systolic hypotension less than or equal to 70 mm Hg, transfusion

195 p < 0.0001); hospital length of stay before hypotension: less than 3 days (+50 min; p < 0.0001), bet

196 (0.81, 1.17) for a 5-minute increase in MAP hypotension < 55 mm Hg time (P = 0.71).

197 here was no adjusted association between SBP hypotension < 80 mm Hg and SSI, with an estimated odds r

198 motension, hypertension (>140/90 mm Hg), and hypotension (<90/60 mm Hg) at visits 1 to 5.

199 , 0-3 points, with 1 point each for systolic hypotension [</=100 mm Hg], tachypnea [>/=22/min], or al

200 rises, hypotensive episodes, and orthostatic hypotension, making it the most difficult form of hypert

201 Furthermore, clinically meaningful hypotension may not be as low as current guidelines sugg

202 onsumption and induce arrhythmias, diastolic hypotension may reduce coronary perfusion and increase i

203 In multivariable analysis, the hypotension, mechanical ventilation, mental status, and

204 Hypotension might thus be expected to promote infection,

205 Among adults with sepsis and hypotension, most of whom were positive for HIV, in a re

206 to respond to vasopressors, which results in hypotension, multiorgan failure, and ultimately patient

207 esthesia), and cardiopulmonary outcomes (ie, hypotension, myocardial infarction, stroke), adjusted fo

208 ortant bradycardia (requiring treatment) and hypotension, myocardial infarction, stroke, surgical sit

209 e diarrhea/colitis (n = 9), pyrexia (n = 4), hypotension (n = 3), and sepsis (n = 3).

210 ; and for midlife hypertension and late-life hypotension (n = 389), 4.26 (95% CI, 3.40-5.32 per 100 p

211 ars); for midlife normotension and late-life hypotension (n = 927), 2.07 (95% CI, 1.68-2.54 per 100 p

212 occurred in four patients (13%) at 6 months: hypotension (n=2), worsening hypertension (n=1), intermi

213 penia (n=12 [11%]), dyspnoea (n=3 [3%]), and hypotension (n=3 [3%]) in the BAT group.

214 ither by MAP target (60-65 mm Hg, permissive hypotension) (n = 1291) or according to usual care (at t

215 tolerated, and no events of hypoglycemia or hypotension occurred among those receiving empagliflozin

216 Symptomatic hypotension occurred in 28 (1%) patients, renal serious

217 Symptomatic hypotension occurred in 9.1% of the patients in the veri

218 Concurrently, progressive systemic hypotension occurred with a fall in left atrial pressure

219 The intervention increased intradialytic hypotension (odds ratio [OR], 7.5; 95% confidence interv

220 y (odds ratio, 1.52; CI, 1.03-2.24), delayed hypotension (odds ratio, 1.42; CI, 1.02-1.99), and incre

221 arrier function to ameliorate trauma-induced hypotension, offering a novel therapeutic opportunity fo

222 and non-motor features including orthostatic hypotension (OH) and cognitive impairment.

223 Review the effect of orthostatic hypotension (OH) and rapid-eye-movement sleep behavioura

224 e is affected by the presence of orthostatic hypotension (OH) in patients with Parkinson's disease de

225 Orthostatic hypotension (OH) is a common cause of transient cerebral

226 esults, we divided patients into orthostatic hypotension (OH), postural tachycardia syndrome (POTS),

227 are concerns that it might cause orthostatic hypotension (OH).

228 In severe falciparum malaria, unlike sepsis, hypotension on admission is uncommon.

229 ly lower after accounting for development of hypotension or AKI.

230 Safety outcomes included life-threatening hypotension or cardiac arrhythmia, endotracheal intubati

231 primary safety outcome was life-threatening hypotension or cardiac arrhythmia.

232 ndan group and the placebo group in rates of hypotension or cardiac arrhythmias.

233 The incidence of hypotension or dizziness was higher in groups that recei

234 eturn, no astronauts experienced orthostatic hypotension or intolerance during routine (for landing d

235 KNO3 did not lead to clinically significant hypotension or methemoglobinemia.

236 CICU admission data based on the presence of hypotension or tachycardia, hypoperfusion, deterioration

237 ear palsy if a patient developed orthostatic hypotension or urinary incontinence with the requirement

238 significantly lower risk of post-intubation hypotension (OR 0.47 [95% CI, 0.31-0.71] P < 0.001).

239 e of the following symptoms: emesis, rigors, hypotension, or flank pain.

240 1 of the following symptoms: emesis, rigors, hypotension, or flank pain.

241 risk of developing in-hospital occurrence of hypotension: OR, 0.254 [95% CI, 0.091-0.706].

242 97 (0.81, 1.17) per 5-minute increase in SBP hypotension (P = 0.54).

243 excessive sedation (p = 0.31), or new-onset hypotension (p = 1.0) that resulted in study drug discon

244 The median time of hypotension per patient was 8.0 minutes (IQR, 1.33-26.00

245 lder receiving vasopressors for vasodilatory hypotension, permissive hypotension compared with usual

246 Whereas neurogenic orthostatic hypotension poses risks for falls and can be associated

247 The rapidly evolving renal failure, hypotension, pressor and steroid use, and variable nutri

248 s Sepsis-3 septic shock if they demonstrated hypotension, received vasopressors, and exhibited a lact

249 ree patients had bradycardia and intractable hypotension requiring inotropes.

250 delayed recognition, emesis with aspiration, hypotension requiring intervention, laryngospasm, pneumo

251 There was a higher rate of hypotension requiring medication adjustment in the aggre

252 cases (15%), including pulmonary hemorrhage, hypotension requiring vasoactive support, conduit disrup

253 be identified using the clinical criteria of hypotension requiring vasopressor therapy to maintain me

254 y failure leading to mechanical ventilation, hypotension requiring vasopressor treatment, or both.

255 hours after status epilepticus, and arterial hypotension requiring vasopressors were independently as

256 was only 1 adverse effect recorded (infusion hypotension) requiring cessation of rituximab.

257 type 2 presentation, defined as progressive hypotension responsive to treatment, was found in 20/33

258 The Delphi process identified hypotension, serum lactate level, and vasopressor therap

259 ning-derived early warning system to predict hypotension shortly before it occurs has been developed

260 tients who were defined as having refractory hypotension, signs of organ hypoperfusion, or both.

261 rade 3-4 adverse event related to NBTXR3 was hypotension (six [7%] of 89 patients).

262 trointestinal tract dysfunction, orthostatic hypotension, sweating abnormalities, or erectile dysfunc

263 or cognitive decline but are associated with hypotension, syncope, and greater medication burden.

264 Orthostatic hypotension, syncope, dyskinesia, hallucinations, prolon

265 CVD death), and (ii) serious adverse events (hypotension, syncope, electrolyte abnormalities, bradyca

266 abdominal pain, nonspecific pain, headache, hypotension/syncope, tachycardia (including postural ort

267 eding requiring transfusion or intervention, hypotension (systolic arterial pressure <=90 mm Hg), and

268 inflammatory response syndrome criteria) and hypotension (systolic blood pressure </=90 mm Hg or mean

269 urgery, all patients experienced episodes of hypotension (systolic blood pressure <= 90 mm Hg) before

270 urgery, all patients experienced episodes of hypotension (systolic blood pressure <=90mmHg) prior to

271 clinical course was complicated by arterial hypotension, tachycardia, decreasing haemoglobin, increa

272 ing one or more affected vital signs (fever, hypotension, tachycardia, or tachypnoea; 96 [44%] of 217

273 irements for managing neurogenic orthostatic hypotension that manifests with falls or cognitive impai

274 tension when treating neurogenic orthostatic hypotension; the effectiveness of nocturnal antihyperten

275 impending hypotension, compared with a basic hypotension threshold alert.

276 Hypotension thresholds that provoke renal injury, myocar

277 was also no adjusted association between MAP hypotension time and SSI, with estimated odds ratio of 0

278 Cohorts were matched for age, hypotension, traumatic brain injury, injury mechanism, a

279 ) manifestations of CRS include tachycardia, hypotension, troponin elevation, reduced left ventricula

280 ity, olfactory loss, depression, orthostatic hypotension, urinary/erectile dysfunction, PD family his

281 eater than 2 mmol/L alone or combinations of hypotension, vasopressors, and serum lactate level 2 mmo

282 The median time-weighted average of hypotension was 0.10 mm Hg (IQR, 0.01-0.43 mm Hg) in the

283 Hypotension was defined as a decrease in the mean arteri

284 Hypotension was defined as a mean arterial pressure (MAP

285 Hypotension was defined as systolic and/or diastolic blo

286 Severe hypotension was more frequent in the more intensive trea

287 Hypotension was observed 30 minutes (95% CI, 15-71) afte

288 The percentage of patients with hypotension was similar in the sotagliflozin group and t

289 Systemic hypotension was the most frequent complication following

290 ions of patients who experienced symptomatic hypotension were 6.4% in the 15-mg/d vericiguat group, 4

291 In conclusion, episodes of hypotension were common during VPI in the ICU.

292 Episodes of hypotension were common, with mean arterial pressure fal

293 fection, tumor seeding, bleeding, and severe hypotension were each observed in 0.3% (one of 320) of p

294 Bradycardia and hypotension were more common in the dexmedetomidine grou

295 ansion, neurologic deterioration, and severe hypotension were not significant.

296 Grade 3 fatigue and hypotension were reported in two patients each (4%).

297 mptoms, erectile dysfunction and orthostatic hypotension) were noted.

298 significant degree and duration of relative hypotension, which is associated with new-onset, adverse

299 toxicities: grade 4 sepsis syndrome, grade 4 hypotension with grade 3 rash and fevers, grade 4 aspart

300 itive impairment, fractures, falls, syncope, hypotension, withdrawals due to adverse events, and acut