ライフサイエンスコーパス: hypothalamic

1 Hypothalamic abnormalities and thermoregulatory dysfunct

2 Using hypothalamic activation as a potential marker for the pr

3 In chronic stress, hypothalamic activation of the pituitary changes from co

4 the expected glucose-induced deactivation of hypothalamic activation, whereas patients with AN and pa

5 e in females only, indicating some impact on hypothalamic activity.

6 ed minimally-invasive methods to measure the hypothalamic-adrenal-pituitary axis (N = 173), immune an

7 Hypothalamic agouti-related peptide (AgRP)-expressing ne

8 d HFD consumption is encoded at the level of hypothalamic agouti-related peptide neurons and mesolimb

9 uncovered important functional properties of hypothalamic Agrp neurons during mouse development, sugg

10 correlates with place preference Mediobasal hypothalamic Agrp neurons inhibit orexin neurons via GAB

11 Here, we found that activation of hypothalamic Agrp neurons rapidly altered whole-body sub

12 Hypothalamic Agrp neurons regulate food ingestion in adu

13 These results indicate a prominent role of hypothalamic alpha-klotho/FGFR1/PI3K signaling in the mo

14 h polycystic ovary syndrome (PCOS; n = 6) or hypothalamic amenorrhea (HA; n = 6).

15 nesis begins as early as E9.5 in the lateral hypothalamic and arcuate and rapidly expands to dorsomed

16 n of basic affective/defensive responses via hypothalamic and brainstem pathways (eg, periaqueductal

17 convey hippocampal population events to its hypothalamic and brainstem targets.

18 l projections accomplish distinct functions: hypothalamic and extended amygdalar projections elicit a

19 sures of corticosterone, c-Fos activation in hypothalamic and limbic structures, and species-typical

20 ivator of transcription 3 phosphorylation in hypothalamic and medullary centers, whereas intraperiton

21 n AgRP cells mitigates highly characteristic hypothalamic and metabolic adaptations induced by weight

22 and specific cell types, including striatal, hypothalamic, and claustrum neurons.

23 Thus, VTA NPY originates from the hypothalamic Arc and the ventrolateral medulla of the br

24 The hypothalamic arcuate kisspeptin neurons are thought to r

25 sfunction in neuropeptide Y (NPY)-expressing hypothalamic arcuate neurons before plaque formation.

26 uin 1 (SIRT1)/FoxO1 signaling pathway in the hypothalamic arcuate nucleus (ARC) mediates MCH-induced

27 Dopamine neurons of the hypothalamic arcuate nucleus (ARC) tonically inhibit the

28 glutamate neurons are sparse in the rostral hypothalamic arcuate nucleus (ARC), the subregion that h

29 3 is expressed in Kiss1 neurons of the mouse hypothalamic arcuate nucleus and that MKRN3 repressed pr

30 Kisspeptin neurons in the hypothalamic arcuate nucleus help convey homeostatic est

31 tide and pro-opiomelanocortin neurons in the hypothalamic arcuate nucleus.

32 The lateral hypothalamic area (LH) is a vital controller of arousal,

33 ynaptic glutamatergic input from the lateral hypothalamic area (LHA) and found that photoinhibition o

34 The lateral hypothalamic area (LHA) coordinates an array of fundamen

35 rveyed functional alterations of the lateral hypothalamic area (LHA)-a highly conserved brain region

36 receptor (KOR), specifically in the lateral hypothalamic area (LHA).

37 sive presence of MCH neurons in the anterior hypothalamic area of Neotomodon.

38 rder connection from vHPC neurons to lateral hypothalamic area orexin (hypocretin)-producing neurons

39 tricular hypothalamic nucleus (PVH), lateral hypothalamic area, and central nucleus of the amygdala (

40 uate nuclei, as well as parts of the lateral hypothalamic area, and it governs a wide range of physio

41 H), the arcuate (ARH) nuclei and the lateral hypothalamic areas (LHA) known to control feeding and mo

42 -expressing neurons in the LS and downstream hypothalamic areas and avoidance behavior, and demonstra

43 Kp fibers are found in various hypothalamic areas, notably the POA, SCN, PVN, DMH, VMH,

44 PDK2 in hypothalamic astrocytes suggest that hypothalamic astrocytes are involved in the diabetic phe

45 on and pharmacological inhibition of PDK2 in hypothalamic astrocytes suggest that hypothalamic astroc

46 neonatal leptin deficiency in vivo activate hypothalamic autophagy-related genes.

47 With a holistic view on hypothalamic-BAT interactions, we aim to raise ideas and

48 results demonstrate the significance of the hypothalamic BBSome for the control of energy balance th

49 aloric intake), is typically associated with hypothalamic brain nuclei, including the paraventricular

50 of sensory and motor features in the medial hypothalamic-brainstem instinctive network.SIGNIFICANCE

51 atic threats recruit neurons across multiple hypothalamic cell populations, which cooperatively drive

52 ear developmental trajectories for all major hypothalamic cell types, and readily distinguished major

53 esponses to FGF1 was observed across diverse hypothalamic cell types, with glial cell types respondin

54 In addition, we found that ventral hypothalamic cells were more prominent in females compar

55 In addition, a potential absence of hypothalamic cholinergic neurons is suggestive of unusua

56 aversive orexin cell activity, and suggest a hypothalamic circuit for fine-tuning orexin signals to c

57 ogether, these findings reveal that LTP at a hypothalamic circuit node mediates a form of experience-

58 BDNF signaling in hypothalamic circuitries regulates mammalian food intake

59 that IRS4(PVH) neurons lie within a complex hypothalamic circuitry that engages distinct hindbrain r

60 e ER stress-autophagy pathway in influencing hypothalamic circuits and metabolic regulation.

61 Our data reveal CNGA3 as a hypothalamic cold sensor and a molecular marker to inter

62 The hypothalamic connectivity suggests distinct roles for th

63 we reveal that Dusp8 is a gatekeeper in the hypothalamic control of glucose homeostasis in mice and

64 hypothalamic valuation signals and amygdala-hypothalamic coupling after a single night of sleep depr

65 a serve as a resource for further studies of hypothalamic development, physiology, and dysfunction.

66 To identify genes that control hypothalamic development, we have used single-cell RNA s

67 re the first to reveal a role for Neurog2 in hypothalamic development.

68 e first used immunohistochemistry to map the hypothalamic distribution of phosphorylated extracellula

69 self-starvation in anorexia nervosa (AN), a hypothalamic dysregulation of energy and glucose homeost

70 ysis suggests SIM1 to confer ED risk through hypothalamic dysregulation.

71 While no changes in hypothalamic E2 were observed, thermoregulation was disr

72 ecific isoform of CPT1C which functions as a hypothalamic energy senor.

73 argeting of the Sim1 promoter or its distant hypothalamic enhancer up-regulated its expression from t

74 leptin-deficient ob/ob mice display elevated hypothalamic ER stress as early as postnatal day 10, i.e

75 trogen negative feedback regulation, whereas hypothalamic ERalpha is necessary for the precise contro

76 Ablation of GHR in TH cells increased the hypothalamic expression of Ghrh mRNA, although very few

77 st the GWAS-identified gene Dusp8 as a novel hypothalamic factor that plays a functional role in the

78 Here, we describe coordinated regulation of hypothalamic feeding and midbrain reward circuits in awa

79 they critically modulate the organization of hypothalamic feeding circuits.

80 nalysis, are postsynaptic targets of lateral hypothalamic GABAergic (LH(GABA)) neurons and that activ

81 RNA sequencing (scRNA-Seq) to profile mouse hypothalamic gene expression across 12 developmental tim

82 Hypothalamic gene expression profiling in postnatal day

83 We further analysed the regulations of hypothalamic genes involved in inflammation and mitochon

84 These data collectively suggest that hypothalamic glial cells are leading targets for the eff

85 ONCLUSIONThese results indicate that blunted hypothalamic glucose reactivity might be related to the

86 n contributes to hypertension via heightened hypothalamic glutamate-dependent signaling.SIGNIFICANCE

87 inuous, as opposed to pulsatile, delivery of hypothalamic gonadotropin-releasing hormone (GnRH) leads

88 BACKGROUNDKisspeptin is a key regulator of hypothalamic gonadotropin-releasing hormone (GnRH) neuro

89 Hypothalamic groups were detected in the suprachiasmatic

90 Experiments in hypothalamic GT1-7 cells observed that alpha-klotho indu

91 developmental anomalies affecting the brain (hypothalamic hamartoma and microcephaly), heart (atriove

92 lar and physiological analyses revealed that hypothalamic HIF2alpha contributes to the action of cent

93 In conclusion, hypothalamic HIF2alpha responds to insulin, and the up-r

94 These findings reveal a novel hypothalamic-hindbrain neuronal circuit for sleep/wake c

95 that obesity triggers broad dysregulation of hypothalamic hunger neurons that is incompletely reverse

96 aim for this study was to elucidate how the hypothalamic hunger-inducing hormone acyl-ghrelin (AG),

97 lly elevated corticosterone levels driven by hypothalamic hyperactivation of Jnk signaling.

98 dehydrogenase kinase (PDK)-2 plays a role in hypothalamic inflammation and its sequelae in mouse mode

99 mouse astrocytes attenuates diabetes-induced hypothalamic inflammation and subsequent alterations in

100 D), administered for one-three-days, induces hypothalamic inflammation before obesity's established,

101 role in the observed metabolic imbalance and hypothalamic inflammation in mouse primary astrocyte and

102 Hypothalamic inflammation plays an important role in dis

103 d that short-term exposure-PM(2.5) increases hypothalamic inflammation, similar to a HFD.

104 These effects are most likely due to chronic hypothalamic inflammation, which is regulated by Tlr4 an

105 Our results point to the involvement of hypothalamic inflammatory and mitochondrial pathways as

106 ermore, administration of TCMCB07 diminished hypothalamic inflammatory gene expression in cancer cach

107 ion of the DUSP8 rs2334499 risk variant with hypothalamic insulin resistance in men.

108 on occurs without impaired activation of the hypothalamic IR/IRS-2/AKT/FOXO1 pathway in response to i

109 th multifaceted secretion, and their derived hypothalamic islets can be implanted peripherally to enh

110 x-specific role of murine Dusp8 in governing hypothalamic Jnk signaling, insulin sensitivity, and sys

111 ependent from its role in the development of hypothalamic kisspeptin neurons or puberty onset.

112 Hypothalamic kisspeptin neurons serve as the nodal regul

113 f overnutrition, acts in the brain to impair hypothalamic leptin action, resulting in increased food

114 trical or optogenetic stimulation of lateral hypothalamic (LH) GABA neurons induces rapid vigorous ea

115 respectively, that regulate the activity of hypothalamic magnocellular neurosecretory neurons (MNNs)

116 Hypothalamic MCH neurons densely innervated the dorsal h

117 n combination with optogenetic activation of hypothalamic melanin-concentrating hormone containing ce

118 not previously implicated in this disorder: hypothalamic melanin-concentrating hormone-expressing ne

119 mediated signaling drives the development of hypothalamic melanocortin circuits involved in energy ho

120 Hypothalamic melanocortins have a potent and long-lastin

121 ity reverted 39 and 78% of total systemic or hypothalamic metabolic variations caused by CR, respecti

122 We identified one hypothalamic metabolite indoxylsulfuric acid and 389 pla

123 ckens, we mapped quantitative trait loci for hypothalamic methylation (methQTL), gene expression (eQT

124 anol or control milk formula for 5 d or from hypothalamic microglia cells obtained from postnatal rat

125 owever, five-days-exposure-PM(2.5) increased hypothalamic microglia density, toll-like-receptor-4 (Tl

126 al repressive regulators of transcription in hypothalamic microglia, while concomitantly increasing h

127 Here, we find a hypothalamic-midbrain circuit that represents hierarchic

128 rmed into a simplified action signal along a hypothalamic-midbrain pathway.

129 sure, causing pubertal alterations, enhanced hypothalamic Mkrn3 and suppressed miR-30b expression in

130 findings identify a reversible plasticity in hypothalamic network activity that can serve to adapt th

131 hol administration into the brain stimulated hypothalamic neural circuits and sympathetic nerves inne

132 In summary, hypothalamic neural stem/progenitor cells comprise subpo

133 and USV(-) mounting use the same or distinct hypothalamic neural substrates.

134 nce for an inhibitory GABAergic Agrp->orexin hypothalamic neurocircuit, and find that Agrp cell suppr

135 in male and female mice showed that tuberal hypothalamic neurogenesis begins as early as E9.5 in the

136 s and the endogenous regulators of postnatal hypothalamic neurogenesis remain elusive.

137 d Fgf10 is a negative regulator of postnatal hypothalamic neurogenesis.

138 regulate the temporal progression of tuberal hypothalamic neurogenesis.SIGNIFICANCE STATEMENT Here, w

139 ogical mechanism contributing to exacerbated hypothalamic neuronal activity during this prevalent neu

140 nfirm a dorsal-ventral patterning to tuberal hypothalamic neuronal birth.

141 omeostatic hormonal and nutrient signals and hypothalamic neuronal pathways.

142 rent internal states are encoded by distinct hypothalamic neuronal populations.

143 highly sophisticated approaches for studying hypothalamic neuronal-glial networks.

144 t dendritic release of vasopressin (VP) from hypothalamic neurones in brain slices.

145 rst in sated mice via activation of specific hypothalamic neurons (AgRP or SFO(GLUT)) restored cue-ev

146 During neurogenesis, tuberal hypothalamic neurons are thought to be born in a dorsal-

147 e generator, a neural construct comprised of hypothalamic neurons coexpressing kisspeptin, neurokoini

148 Application of this method to hypothalamic neurons controlling physiological responses

149 anistically, we found that ALK expression in hypothalamic neurons controls energy expenditure via sym

150 ssibility that amyloid-beta (Abeta) disrupts hypothalamic neurons critical for the regulation of body

151 physiology, we discovered a core ensemble of hypothalamic neurons in and near the supraoptic nucleus,

152 Hypothalamic neurons including proopiomelanocortin (POMC

153 lock network and are closely juxtaposed with hypothalamic neurons involved in regulation of sleep/wak

154 esized in histidine decarboxylase-expressing hypothalamic neurons of the tuberomammillary nucleus.

155 Hypothalamic neurons sense these needs and must coordina

156 cium (Ca(2+)) indicator GCaMP6 in individual hypothalamic neurons that contain MCH.

157 ly identified neuropeptide VF (NPVF) and the hypothalamic neurons that produce it as a sleep-promotin

158 Most brain neurons are active in waking, but hypothalamic neurons that synthesize the neuropeptide me

159 ral anatomical and neurochemical features of hypothalamic neurons were described during the past deca

160 ion in SF1 cells, which include ventromedial hypothalamic neurons, also attenuated the CRR.

161 f ciliogenesis in POMC-expressing developing hypothalamic neurons, by depleting ciliogenic genes IFT8

162 of appetite has been extensively studied in hypothalamic neurons, its function in the hippocampus, w

163 ity between SCN(VIP) neurons and dorsomedial hypothalamic neurons, providing a circuit substrate by w

164 cholinergic, including specific thalamic and hypothalamic neurons, the subiculum, the lateral parabra

165 uired to decode the taxonomical hierarchy of hypothalamic neurons.

166 he recovery of hypoglycemia via ventromedial hypothalamic neurons.

167 hormone (GnRH) secretion from a few thousand hypothalamic neurons.

168 h is mediated by primary cilia in developing hypothalamic neurons.

169 The hypothalamic neuropeptide Y (NPY) circuitry is a key reg

170 s are originally characterized as orexigenic hypothalamic neuropeptides in mammals.

171 xin A (OXA) and neuropeptide Y (NPY) are two hypothalamic neuropeptides involved in the regulation of

172 The two hypothalamic neuropeptides oxytocin and melanin concentr

173 pherical structure with combined features of hypothalamic neurospheres and pancreatic islets.

174 onal cell types that coexist in intercalated hypothalamic nuclei and communicate through extensive sy

175 motor behavior by DA neurons within multiple hypothalamic nuclei and elucidate a novel functional mec

176 eriventricular, paraventricular, and arcuate hypothalamic nuclei and locus ceruleus of mice exhibited

177 l regulation except the hypothalamus and two hypothalamic nuclei display sexually dimorphic OTR expre

178 reoptic, ventromedial (VMH), paraventricular hypothalamic nuclei, and in the bed nucleus of the stria

179 cted arcuate (ARC) and paraventricular (PVN) hypothalamic nuclei.

180 a range of upstream brain regions as well as hypothalamic nuclei.

181 nd light to intense innervation of all these hypothalamic nuclei.

182 ), dorsomedial (DMH), and ventromedial (VMH) hypothalamic nuclei.

183 orded from OT neurons in the paraventricular hypothalamic nucleus (PVH) to show that social stimulus

184 The paraventricular hypothalamic nucleus (PVH), lateral hypothalamic area, a

185 ha receptor 1 (TNFR1) in the paraventricular hypothalamic nucleus (PVN), a critical neuroregulator of

186 entrolateral subdivision of the ventromedial hypothalamic nucleus (vlVMH) can sense glucose fluctuati

187 y functioning cell types in the ventromedial hypothalamic nucleus (VMN), we studied the cholecystokin

188 -> nucleus of the solitary tract and arcuate hypothalamic nucleus -> paraventricular nucleus axonal f

189 HPA effector neurons in the paraventricular hypothalamic nucleus, and to aspects of the midbrain per

190 ion of the thalamic nucleus, paraventricular hypothalamic nucleus, arcuate hypothalamic nucleus, prim

191 araventricular hypothalamic nucleus, arcuate hypothalamic nucleus, primary and secondary somatosensor

192 OB, the posterior tuberculum, and the dorsal hypothalamic nucleus, suggesting the presence of both in

193 lack of Pdyn projections to the ventromedial hypothalamic nucleus.

194 source of novel drug targets, we discuss the hypothalamic orchestration of BAT activity and the relat

195 inhibition of endogenous activity of lateral hypothalamic orexin neurons causes place preference and

196 Selective knockdown of lateral hypothalamic orexin neurons reduced motivation for cocai

197 Hypothalamic orexin/hypocretin neurons integrate multipl

198 the SNS/BAT/thermogenesis axis; conversely, hypothalamic overexpression of human SH2B1 has the oppos

199 In contrast, hypothalamic overexpression of SH2B1 protects against hi

200 cess that required cortical activity and the hypothalamic oxytocin system.

201 trated that relaxin-3/RXFP3 signaling in the hypothalamic paraventricular nucleus (PVN) is necessary

202 d-aspartate receptor (NMDAR) activity in the hypothalamic paraventricular nucleus (PVN) plays a major

203 ole in heightened glutamate signaling in the hypothalamic paraventricular nucleus (PVN), a key centra

204 teral septum, ventromedial hypothalamus, and hypothalamic paraventricular nucleus.

205 inal fluid-contacting (CSF-c) neurons of the hypothalamic paraventricular organ and the central canal

206 en tanycytes and neural cells present in the hypothalamic parenchyma, in particular in the arcuate nu

207 third ventricle and send processes into the hypothalamic parenchyma.

208 d can reduce food consumption via effects on hypothalamic pathways.

209 al, but the molecular mechanisms controlling hypothalamic patterning and cell fate specification are

210 ental evolution of retinal morphogenesis and hypothalamic patterning are among those traits that reta

211 ively characterize mutants that have altered hypothalamic patterning, identifying Nkx2.1 as a negativ

212 ce multiple pancreatic, gastrointestinal and hypothalamic peptides in addition to exosomes.

213 e (RF)-amide related peptide-3 (RFRP-3), two hypothalamic peptides known to regulate the mammalian hy

214 ma) and centrally (NTS and RVLM) and reduced hypothalamic PGE(2) production, which are all associated

215 n the association between functioning of the hypothalamic pituitary adrenal (HPA) axis and cognitive

216 sity, in which elevated leptin maintains the hypothalamic pituitary thyroid axis, despite leptin resi

217 Dysregulation of hypothalamic-pituitary estrogen receptor alpha-mediated

218 of the hypothalamic-pituitary-adrenal (HPA), hypothalamic-pituitary thyroid (HPT), and hypothalamic-p

219 Hypothalamic-pituitary-adrenal (HPA) axis dysfunction co

220 rocesses as well as emotional reactivity and hypothalamic-pituitary-adrenal (HPA) axis functioning.

221 Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis occurs early i

222 The hypothalamic-pituitary-adrenal (HPA) axis regulates resp

223 The hypothalamic-pituitary-adrenal (HPA) axis, a neuroendocr

224 In vertebrates, predation risk activates the hypothalamic-pituitary-adrenal (HPA) axis, and there is

225 production is affected by senescence of the hypothalamic-pituitary-adrenal (HPA) axis, leading to pr

226 ure resulted in persistent alteration of the hypothalamic-pituitary-adrenal (HPA) axis.

227 on (focusing on immune, cardiometabolic, and hypothalamic-pituitary-adrenal (HPA) systems) in first-e

228 The authors describe the physiology of the hypothalamic-pituitary-adrenal (HPA), hypothalamic-pitui

229 Hypothalamic-pituitary-adrenal (HPA)-axis hyperactivity

230 rticoid hormone concentrations (a measure of hypothalamic-pituitary-adrenal [HPA] axis activation and

231 We tested the hypothesis that maternal hypothalamic-pituitary-adrenal axis activity, measured b

232 Lower hypothalamic-pituitary-adrenal axis and autonomic reacti

233 d maltreatment, including alterations in the hypothalamic-pituitary-adrenal axis and inflammatory cyt

234 Second, we review the role of hypothalamic-pituitary-adrenal axis dysfunction in the n

235 Mechanistically, we found impaired hypothalamic-pituitary-adrenal axis feedback, blunted sy

236 The hypothalamic-pituitary-adrenal axis modulates immunity i

237 tress impacts health, such as by influencing hypothalamic-pituitary-adrenal axis regulation and corti

238 e engagement with targets in the adrenergic, hypothalamic-pituitary-adrenal axis, and neuropeptide Y

239 n of which is mediated and controlled by the hypothalamic-pituitary-adrenal axis.

240 mediating stress response by activating the hypothalamic-pituitary-adrenal axis.

241 Nonhuman animal models reveal that the hypothalamic-pituitary-adrenocortical (HPA) axis calibra

242 ing endocrine step, namely activation of the hypothalamic-pituitary-adrenocortical (HPA) axis.

243 ), hypothalamic-pituitary thyroid (HPT), and hypothalamic-pituitary-gonadal (HPG) axes and review the

244 Polycystic ovary syndrome (PCOS) is a hypothalamic-pituitary-gonadal (HPG) axis disorder.

245 In women, suppression of the hypothalamic-pituitary-gonadal axis appears to be a prin

246 Conditions impairing the hypothalamic-pituitary-gonadal axis during paediatric or

247 The hypothalamic-pituitary-gonadal axis is of relevance in m

248 s (ERK) 1 and 2 regulate many aspects of the hypothalamic-pituitary-gonadal axis.

249 secreting GnRH to activate and maintain the hypothalamic-pituitary-gonadal axis.

250 RKOGFAP mice show normal sexual behavior but hypothalamic-pituitary-gonadotropin (HPG) axis dysregula

251 Although the hypothalamic-pituitary-thyroid axis is under the control

252 pulation of food availability confirmed that hypothalamic pomc mRNA expression is dependent on longer

253 Although the relevance of hypothalamic POMC neurons in the regulation of body weig

254 Here, we report that hypothalamic Pomc neurons in zebrafish and mice have lon

255 dulthood also led to persistent reduction in hypothalamic Pomc, Cartpt and Prlh mRNA expression and t

256 ings indicate the existence of a novel mouse hypothalamic population that may signal through the rele

257 Hypothalamic preoptic area (POA) neurons are intimately

258 (3) and skin(4) but is also expressed in the hypothalamic preoptic area (POA)(5).

259 hemogenetic inhibition of KOR neurons in the hypothalamic preoptic area reduced the CR-induced hypoth

260 urogenin 3 (Neurog3) are widely expressed in hypothalamic progenitors and contribute to lineage commi

261 d NPY/AgRP neurons are derived from the same hypothalamic progenitors but have opposing effects on fo

262 A new study reveals that a hypothalamic projection pathway critical for female sexu

263 nic hypertension, which is caused by reduced hypothalamic prostaglandin E(2) production and increased

264 BMAL1, a core clock gene, in paraventricular hypothalamic (PVH) neurons reduces diurnal rhythmicity i

265 Therefore, we investigated whether hypothalamic reactivity to glucose metabolism is impaire

266 and participants with obesity showed blunted hypothalamic reactivity.

267 ntricular hypothalamic zone, periventricular hypothalamic region, and lateral hypothalamic zone.

268 the role of astrocytes in the maturation of hypothalamic reproductive circuits.

269 L had smaller olfactory bulbs, yet increased hypothalamic response in association with men's body-odo

270 s endothelial fenestrations and enhances the hypothalamic response to the circulating hormone leptin,

271 r the median eminence to trigger homeostatic hypothalamic responses is not well understood.

272 associated ionic mechanisms, and reveal that hypothalamic RLN3/RXFP3 signaling regulates binge-eating

273 gions and is innervated by discrete upstream hypothalamic sites.

274 In contrast, hypothalamic-specific ablation of Fgf13 recapitulated we

275 Besides, decreased hypothalamic STAT3-phosphorylation and Pomc expression w

276 We report that mouse hypothalamic stem/progenitor cells produce multiple panc

277 Hypothalamic stimulation can elicit complex behaviors su

278 ensitivity in both the extrahypothalamic and hypothalamic stress circuits in abstinent rhesus males.

279 (BNST), well connected to the amygdala, and hypothalamic structures such as the paraventricular (PVH

280 Together, these data identify a hypothalamic subpopulation that is genetically enriched

281 orexin-expressing neurons within the lateral hypothalamic subregion.

282 ng functional MRI (fMRI) that at least three hypothalamic subsystems are involved in cardiovascular r

283 The hypothalamic suprachiasmatic (SCN) clock contains severa

284 The hypothalamic suprachiasmatic nuclei (SCN) are the princi

285 ed by the principal circadian pacemaker, the hypothalamic suprachiasmatic nucleus (SCN).

286 ial nerve palsies, brain/eye involvement, or hypothalamic syndrome) were ineligible.

287 tria terminalis (BNST) is part of the limbic-hypothalamic system important for behavioral responses t

288 tria terminalis (BNST) is part of the limbic-hypothalamic system important for behavioral responses t

289 Hypothalamic tanycytes are chemosensitive glial cells th

290 ers coexist in each neuron, we determined if hypothalamic TH-immunoreactive (ir) neurons express vesi

291 Extracellular vesicles were prepared from hypothalamic tissues collected from postnatal rats (both

292 These results point to a critical role for hypothalamic TNFR1 signaling in hypertension.

293 m multiple sources including from the retino-hypothalamic tract and from astrocytes.

294 by using temporally resolved analysis of the hypothalamic transcriptome in celastrol-treated DIO, lea

295 ternative polyadenylation (APA) sites within hypothalamic transcripts to regulate transcriptomic func

296 Hypothalamic urotensin I mRNA levels also increased in s

297 aling a food-reward-specific upregulation of hypothalamic valuation signals and amygdala-hypothalamic

298 ent an in-depth review of co-transmission in hypothalamic WPNs and SPNs and discuss its functional si

299 s localized primarily to the periventricular hypothalamic zone, periventricular hypothalamic region,

300 ventricular hypothalamic region, and lateral hypothalamic zone.