ライフサイエンスコーパス: hypoxia-inducible factor

1 nse genes is controlled by the heterodimeric Hypoxia-Inducible Factor.

2 poxic human cells requires the activation of hypoxia inducible factor 1 (HIF-1) and not HIF-2.

3 Hypoxia inducible factor 1 (HIF-1) up-regulates the expr

4 production of reactive oxygen species (ROS), hypoxia inducible factor 1 alpha (HIF-1alpha), and its t

5 mphedema, there is a significant increase of hypoxia inducible factor 1 alpha (HIF-1alpha), but a red

6 ovascular, resulting in the up-regulation of hypoxia inducible factor 1 alpha (HIF1A), which promotes

7 from hydroxylating the transcription factor hypoxia inducible factor 1 alpha (HIF1alpha), targeting

8 The hypoxia inducible factor 1 alpha subunit (HIF1A) directl

9 found that E2 and PPT induced the binding of hypoxia inducible factor 1 alpha subunit (HIF1A) in the

10 he stricture phenotype of ISMC showed stable hypoxia inducible factor 1 subunit alpha expression that

11 phenotypic markers, and stable expression of hypoxia inducible factor 1 subunit alpha.

12 dies with the hydroxylase, factor inhibiting hypoxia-inducible factor 1 (FIH-1), we observed increase

13 ugh activation of transcription factors like hypoxia-inducible factor 1 (HIF-1) and c-Myc, yet the im

14 Hilpda proved to be a target of hypoxia-inducible factor 1 (Hif-1) and peroxisome prolif

15 Hypoxia-inducible factor 1 (HIF-1) has been recognized a

16 recent work delineating mechanisms by which hypoxia-inducible factor 1 (HIF-1) mediates adaptive met

17 Here, we delineate a pathway controlled by hypoxia-inducible factor 1 (HIF-1) that epigenetically a

18 ia-induced amoeboid detachment was driven by hypoxia-inducible factor 1 (HIF-1), followed the downreg

19 adhesion molecule 1, IL-10, heme oxygenase 1 hypoxia-inducible factor 1 (HIF-1), monocyte chemotactic

20 nts by activating the transcription factors, hypoxia-inducible factor 1 (HIF1) and HIF2.

21 ngiogenic factors were partially mediated by hypoxia-inducible factor 1 alpha (HIF-1alpha) and recomb

22 Hypoxia-inducible factor 1 alpha (Hif-1alpha) is a neces

23 heckpoints, as well as impaired induction of hypoxia-inducible factor 1 alpha (HIF-1alpha).

24 Levels of hypoxia-inducible factor 1 alpha (HIF1alpha) mRNA, a tar

25 utyrate (SB) may indirectly (through reduced hypoxia-inducible factor 1 alpha stabilization) decrease

26 activated phenotype (increased expression of hypoxia-inducible factor 1 alpha, glucose transporter 1,

27 We found that wild-type p53 and hypoxia-inducible factor 1 co-regulate hDBR1 expression,

28 The hypoxia-inducible factor 1 signaling pathway was enriche

29 g axis towards glycolysis with activation of hypoxia-inducible factor 1 subunit alpha (HIF-1alpha) an

30 We measured levels and stability of the hypoxia-inducible factor 1 subunit alpha (HIF1A), endoth

31 , vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1-alpha (HIF-1alpha) and erythr

32 that the expression of NLRP3 is mediated by hypoxia-inducible factor 1-alpha (HIF-1alpha) during the

33 NAT1 deletion also up-regulated hypoxia-inducible factor 1-alpha (HIF1-alpha).

34 We demonstrate that hypoxia-inducible factor 1-alpha (HIF1A) inhibition in l

35 and c-MYC protein levels as well as elevated hypoxia-inducible factor 1-alpha activity.

36 1, and the downstream transcription factors hypoxia-inducible factor 1-alpha and c-Myc, which togeth

37 was associated with increased expression of hypoxia-inducible factor 1-alpha and glucose transporter

38 TLR-primed cells was dependent, in part, on hypoxia-inducible factor 1-alpha and was essential for i

39 Increased hypoxia-inducible factor 1-alpha expression in the MP gr

40 Expression of hypoxia-inducible factor 1-alpha peaked in the SCS-group

41 cIH induced systemic insulin resistance in a hypoxia-inducible factor 1-independent manner and impair

42 ontaining family, pyrin domain-containing-3; hypoxia-inducible factor 1/2alpha; and NF-kappaB were al

43 activated mTORC1 and downstream upregulated hypoxia inducible factor-1 (HIF-1alpha) expression.

44 In parallel, hypoxia inducible factor-1 alpha (HIF-1alpha) activates

45 poxia-inducible angiogenic pathway involving hypoxia inducible factor-1 alpha (HIF-1alpha), vascular

46 is reversed by allowing the stabilization of Hypoxia Inducible Factor-1 alpha (HIF-1alpha).

47 Hypoxia-inducible factor-1 (HIF-1) is a key gene regulat

48 LOX in colorectal cancer synergizes with hypoxia-inducible factor-1 (HIF-1) to promote tumor prog

49 the effects of pharmacological inhibition of hypoxia-inducible factor-1 (HIF-1), a critical regulator

50 Exposure to SB also suppressed hypoxia-inducible factor-1 (HIF-1alpha) stabilization an

51 label exchange between pyruvate and lactate, hypoxia-inducible factor-1 (HIF1alpha), and the monocarb

52 hown to reduce oxidative stress and increase hypoxia-inducible factor-1 alpha (HIF-1alpha) activation

53 eport that tamoxifen decreases the levels of hypoxia-inducible factor-1 alpha (HIF-1alpha) and the sy

54 ngiogenic effect, CSCs were transfected with hypoxia-inducible factor-1 alpha (HIF-1alpha) by using e

55 Hypoxia-inducible factor-1 alpha (HIF-1alpha) is express

56 ially via direct and indirect effects of the hypoxia-inducible factor-1 alpha (HIF-1alpha) transcript

57 se inhibitors (PHI) promote stabilization of hypoxia-inducible factor-1 alpha and affect signaling ca

58 allogeneic recipients resulted in increased hypoxia-inducible factor-1 alpha expression and reduced

59 e B), SRC, and overexpression of HIF1-alpha (hypoxia-inducible factor-1 alpha), survivin, and VWF (Vo

60 oxide dismutase (SOD2), increases HIF1alpha (hypoxia-inducible factor-1), reduces endothelial cadheri

61 Increased Hypoxia Inducible Factor 1A (HIF1A)-associated signaling

62 IF-1alpha and HIF-2alpha proteins.IMPORTANCE Hypoxia inducible factor 1alpha (HIF-1alpha) and HIF-2al

63 We hypothesized that hypoxia inducible factor 1alpha (HIF-1alpha) in CNS resp

64 a hypoxia-induced pathway that utilizes the Hypoxia Inducible Factor 1alpha (HIF-1alpha) transcripti

65 We hypothesized that hypoxia inducible factor 1alpha (HIF-1alpha), an O(2) -s

66 Our studies revealed that orthologs of Hypoxia inducible factor 1alpha (HIF1alpha) and Lactate

67 Endotoxemia upregulates Hypoxia inducible factor 1alpha, which in turn transcrip

68 Given that Leishmania parasites activate hypoxia-inducible factor 1alpha (HIF-1alpha) and this tr

69 trix (ECM) remodeling and angiogenesis, with hypoxia-inducible factor 1alpha (HIF-1alpha) being a maj

70 orted that the cellular transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) binds a hyp

71 Both prostaglandin E(2) (PGE(2)) and hypoxia-inducible factor 1alpha (HIF-1alpha) contribute

72 We show that endothelial hypoxia-inducible factor 1alpha (HIF-1alpha) controls gl

73 d growth, blood vessel density, and VEGF and hypoxia-inducible factor 1alpha (HIF-1alpha) expression

74 Hypoxia-inducible factor 1alpha (HIF-1alpha) is a major

75 The hypoxia-inducible factor 1alpha (HIF-1alpha) is critical

76 Hif1a gene encoding the transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha) is mediated

77 Ectopic expression of miR-211 reduced hypoxia-inducible factor 1alpha (HIF-1alpha) protein lev

78 Inhibition of PDK1 or knockout of hypoxia-inducible factor 1alpha (HIF-1alpha) reversed th

79 Hypoxia-inducible factor 1alpha (HIF-1alpha), a principa

80 m a wide variety of partners, including p53, hypoxia-inducible factor 1alpha (HIF-1alpha), NF-kappaB,

81 ed by ERalpha, but it became predominantly a hypoxia-inducible factor 1alpha (HIF-1alpha)-dependent g

82 oxic regions identified by the expression of hypoxia-inducible factor 1alpha (HIF-1alpha).

83 by the oxygen-sensitive transcription factor hypoxia-inducible factor 1alpha (HIF-1alpha).

84 ow that Parkin is an E3 ubiquitin ligase for hypoxia-inducible factor 1alpha (HIF-1alpha).

85 santin including NF-kappaB, MAPK, STAT3, and hypoxia-inducible factor 1alpha (HIF-1alpha).

86 cells respond to hypoxia by upregulating the hypoxia-inducible factor 1alpha (HIF1A) transcription fa

87 ulatory signal that controls the activity of Hypoxia-Inducible Factor 1alpha (Hif1a), a mediator of t

88 am target genes for the hypoxia marker gene, hypoxia-inducible factor 1alpha (HIF1A).

89 romoting aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor 1alpha (HIF1alpha) expression,

90 es at birth, and the von Hippel-Lindau (VHL)-hypoxia-inducible factor 1alpha (Hif1alpha) pathway regu

91 We identified induction of CD36 and hypoxia-inducible factor 1alpha (HIF1alpha) proteins as

92 oC activation modulated the stabilization of hypoxia-inducible factor 1alpha (HIF1alpha) to upregulat

93 Overexpression of hypoxia-inducible factor 1alpha (HIF1alpha), glucose tra

94 oxia-inducible factor 2alpha (HIF2alpha) and hypoxia-inducible factor 1alpha (HIF1alpha), were enrich

95 hat SHH-treated CGNPs feature high levels of hypoxia-inducible factor 1alpha (HIF1alpha), which is kn

96 e dehydrogenase (PDH) in an NO-dependent and hypoxia-inducible factor 1alpha (Hif1alpha)-independent

97 set of physiologically important mRNAs (e.g. hypoxia-inducible factor 1alpha [HIF-1alpha], fibroblast

98 Expression of hypoxia-inducible factor 1alpha and heme oxygenase 1 in

99 Production of HERNA1 is initiated by direct hypoxia-inducible factor 1alpha binding to a hypoxia-res

100 ion, conservation with the human genome, and hypoxia-inducible factor 1alpha dependence.

101 Hypoxia-inducible factor 1alpha immunostaining was highe

102 vacuoles within knockout cardiomyocytes; (3) Hypoxia-inducible factor 1alpha protein instability was

103 at reduced Nkx2-5 expression and a prolonged hypoxia-inducible factor 1alpha response together precip

104 ent toward the growing end of the neuron via hypoxia-inducible factor 1alpha signaling.

105 HIF-1alpha (hypoxia-inducible factor 1alpha) directly bound to the P

106 one morphogenetic protein 4) and HIF-1alpha (hypoxia-inducible factor 1alpha), blocking the BMP4/ALK

107 genous RNA sequesters miRNA let-7 to release Hypoxia-inducible factor 1alpha, leading to an increase

108 hat previously reported at high altitude for hypoxia-inducible factor 1alpha.

109 HIF (hypoxia-inducible factor)-1alpha is a major determinant

110 gen peroxide production and inactivated HIF (hypoxia-inducible factor)-1alpha, which was pathological

111 (PAECs), expression of transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) is increase

112 nstrate that MUC1-regulated stabilization of hypoxia inducible factor-1alpha (HIF-1alpha) mediates su

113 The transcription factor hypoxia inducible factor-1alpha (HIF-1alpha) was recentl

114 DF-induced metabolic reprogramming required hypoxia inducible factor-1alpha (HIF-1alpha), downstream

115 ed 3D-printed hydrogel scaffolds seeded with hypoxia inducible factor-1alpha (HIF-1alpha)-mutated mus

116 Here we demonstrate that Hypoxia inducible factor-1alpha (Hif1alpha), a key media

117 Loss of smooth muscle cell hypoxia inducible factor-1alpha underlies increased vasc

118 lular metabolism, including up-regulation of hypoxia inducible factor-1alpha's downstream processes a

119 show detectable levels of the marker protein hypoxia-inducible factor-1alpha (HIF-1alpha) after 3 h o

120 tress-induced p53 physically interacted with hypoxia-inducible factor-1alpha (HIF-1alpha) and attenua

121 Here, we report that hypoxia-inducible factor-1alpha (HIF-1alpha) is crucial

122 The hypoxia-inducible factor-1alpha (HIF-1alpha) promotes an

123 rotein-1-like (HSPA1L) expression stabilized hypoxia-inducible factor-1alpha (HIF-1alpha) protein and

124 diated PHLPP1 transcriptional inhibition and hypoxia-inducible factor-1alpha (HIF-1alpha) protein tra

125 The role of C/EBPbeta and hypoxia-inducible factor-1alpha (HIF-1alpha) signaling w

126 Hypoxia-inducible factor-1alpha (HIF-1alpha), a transcri

127 Herein, we show that hypoxia-inducible factor-1alpha (HIF-1alpha), expressed

128 nd VAT with downregulation of OPN, activated hypoxia-inducible factor-1alpha (HIF-1alpha), proliferat

129 diseases and identify their association with hypoxia-inducible factor-1alpha (HIF-1alpha), vascular e

130 NBC cells secrete high levels of GM-CSF in a hypoxia-inducible factor-1alpha (HIF1alpha)- and a NF-ka

131 n of the profibrotic markers fibronectin and hypoxia-inducible factor-1alpha and reversed TGF-beta1-i

132 f IDH2 caused ROS-dependent stabilization of hypoxia-inducible factor-1alpha in normoxia, which was r

133 evelopment of PH, mice lacking expression of hypoxia-inducible factor-1alpha in the Ly6C(lo) monocyte

134 e regulated by hypoxia-inducible factor, and hypoxia-inducible factor-1alpha induction was attenuated

135 In addition, there was reduced expression of hypoxia-inducible factor-1alpha relevant in the pathogen

136 a2 regulates alpha-ketoglutarate generation, hypoxia-inducible factor-1alpha stability, and neutrophi

137 pha-ketoglutarate, which negatively regulate hypoxia-inducible factor-1alpha stability, were attenuat

138 s accompanied by nonheme iron deposition and hypoxia-inducible factor-1alpha upregulation in the rena

139 kinase M2), phosphorylated PKM2, HIF-1alpha (hypoxia-inducible factor-1alpha), and lactate.

140 phosphorylated PKM2, succinate, HIF-1alpha (hypoxia-inducible factor-1alpha), lactate, and the IL-1b

141 f hypoxia through suppression of HIF-1alpha (hypoxia-inducible factor-1alpha)-mediated neutrophil ada

142 A negatively regulates the metabolic sensor, hypoxia-inducible factor-1alpha, and key inflammatory pr

143 sues (eg, succinate, adenosine triphosphate, hypoxia-inducible factor-1alpha, nuclear factor erythroi

144 : IL-1R-associated kinase-M, NFkB2/p100, and hypoxia-inducible factor-1alpha.

145 (ROS), leading to lactate production through hypoxia-inducible factor-1alpha.

146 east cancer and its expression is induced by hypoxia-inducible factor 2 (HIF2), but not HIF1, in resp

147 yl hydroxylase gene (PHD) 1 and 2 and in the hypoxia-inducible factor 2 alpha (HIF2A) were also found

148 model, we show that the transcription factor hypoxia-inducible factor 2 alpha (Hif2alpha), which is i

149 ongoing with the reduction in hepatocellular hypoxia inducible factor 2a (Hif2a).

150 Inhibition of Hypoxia inducible factor 2alpha (HIF-2alpha) and the Pho

151 ariant mapped to the EPAS1 gene encoding the hypoxia inducible factor 2alpha.

152 The hypoxia-inducible factor 2alpha (HIF-2alpha) is a key on

153 on the oxygen-regulated transcription factor hypoxia-inducible factor 2alpha (HIF-2alpha).

154 idney cancer, and causes the accumulation of hypoxia-inducible factor 2alpha (HIF-2alpha).

155 portant transcription factor-binding motifs, hypoxia-inducible factor 2alpha (HIF2alpha) and hypoxia-

156 Hypoxia-inducible factor 2alpha (HIF2alpha) directly reg

157 gets in ccRCC downstream of VHL loss besides hypoxia-inducible factor 2alpha (HIF2alpha).

158 expression changes that suggested increased hypoxia-inducible factor 2alpha signaling.

159 en homeostasis maintaining pathway involving Hypoxia-inducible factor 2alpha.

160 expression was downregulated, which involved hypoxia inducible factor-2alpha-dependent transcriptiona

161 y the hypoxia-inducible transcription factor hypoxia-inducible factor-2alpha (HIF-2alpha) as the top

162 ), leading to inappropriate stabilization of hypoxia-inducible factor-2alpha (HIF-2alpha).

163 entially bound to the promoter and activated hypoxia-inducible factor-2alpha (HIF2alpha) in Sca-1(+)

164 Hypoxia-inducible factor-2alpha (HIF2alpha) is a nuclear

165 Thus, targeting PHD2/hypoxia-inducible factor-2alpha signaling is a promising

166 exhibit decreased expression of HIF-2alpha (hypoxia-inducible factor-2alpha)-regulated genes, and to

167 regulated the expression of the Egl-9 family hypoxia inducible factor 3(EGLN3) gene and targeted a si

168 component of a ubiquitin ligase complex) and hypoxia-inducible factors (a family of transcription fac

169 iferation and blood vessel formation through hypoxia inducible factor alpha (HIFalpha)-activated Wnt

170 in mammals that posttranslationally modifies hypoxia-inducible factor alpha (HIF-alpha) and targets i

171 Although LSD1-induced hypoxia-inducible factor alpha (HIF1alpha) demethylation

172 dent prolyl hydroxylase (PHD) reaction, with hypoxia-inducible factor alpha (HIFalpha) being its most

173 In the developing CNS, hypoxia-inducible factor alpha (HIFalpha) is a key regul

174 xposed to physiological hypoxia, under which hypoxia-inducible factor alpha (HIFalpha) is stabilized

175 ein (pVHL), resulting in the accumulation of hypoxia-inducible factor alpha-subunits (HIF-alpha) and

176 s an O(2) sensor that controls levels of the Hypoxia Inducible Factor-alpha (HIF-alpha), which regula

177 ippel-Lindau tumor suppressor, which targets Hypoxia-Inducible Factor-alpha to the proteasome.

178 he activity of the transcription factor HIF (hypoxia-inducible factor) and its regulatory hydroxylase

179 on NF-kappaB (nuclear factor-kappa B), HIF (hypoxia-inducible factor), and angiogenic response were

180 y angiogenic growth factors are regulated by hypoxia-inducible factor, and hypoxia-inducible factor-1

181 Whether antenatal or postnatal HIF (hypoxia-inducible factor) augmentation can preserve lung

182 ascular endothelial growth factor (VEGF) and hypoxia-inducible factor by using a histone deacetylase

183 1 (EPAS1), a regulatory alpha subunit of the hypoxia-inducible factor complex, during angiotensin II-

184 Hypoxia activates hypoxia-inducible factor-dependent signaling, which in t

185 ssion of parenchymal injury transcripts (eg, hypoxia-inducible factor EGLN1).

186 ional program, mediated predominantly by the hypoxia inducible factor family of transcription factors

187 n within GPe PV(+) neurons were enriched for hypoxia-inducible factor family binding motifs.

188 The inhibition of hypoxia inducible factor (HIF) and the mTOR pathways has

189 The prolyl hydroxylase domain (PHD)-hypoxia inducible factor (HIF) pathway is a key mammalia

190 onocytes showed enrichment for metabolic and hypoxia inducible factor (HIF) pathways in sarcoidosis.

191 atically alters mitochondrial metabolism and hypoxia inducible factor (HIF) signaling due to iron dep

192 nes, treatment with chemicals that stabilize hypoxia inducible factor (HIF), including desferrioxamin

193 The role of prolyl hydroxylase (PHD)-3 as a hypoxia inducible factor (HIF)-1alpha cofactor is contro

194 Over-activation of hypoxia inducible factor (HIF)-1alpha has been implicate

195 r 24 hours, or by APC specific deficiency in hypoxia inducible factor (HIF)-2alpha, an oxygen labile

196 e to hydroxylate specific prolyl residues on hypoxia inducible factor (HIF)-alpha proteins, labeling

197 geted therapeutics, such as those abrogating hypoxia inducible factor (HIF)/vascular endothelial grow

198 The effects of pharmacologic inhibitors of hypoxia-inducible factor (HIF) 1alpha and HIF-2alpha wer

199 lysis, we identified increased expression of hypoxia-inducible factor (HIF) 1alpha target genes (expr

200 ted information on the importance of the VHL-hypoxia-inducible factor (HIF) axis to human phenotypes.

201 On the one hand, knockdown of hypoxia-inducible factor (HIF) beta in the VHL-deficient

202 nfected corneas, and the outcome of blocking hypoxia-inducible factor (HIF) dimerization on the sever

203 rt of an E3-ligase complex which targets the hypoxia-inducible factor (HIF) for degradation.

204 We also observed that depletion of the hypoxia-inducible factor (HIF) genes, HIF1A (encoding HI

205 Here we uncovered a role for intestinal hypoxia-inducible factor (HIF) in hepatic steatosis.

206 prominent role for the transcription factor hypoxia-inducible factor (HIF) in the regulation of inna

207 Hypoxia-inducible factor (HIF) is a key transcriptional

208 vironment with variable hypoxia, but whether hypoxia-inducible factor (HIF) is involved is unknown.

209 As the most studied O2 "sensor," hypoxia-inducible factor (HIF) is regarded as an importa

210 Hypoxia-inducible factor (HIF) is strikingly upregulated

211 e overlap between cis-acting elements of the hypoxia-inducible factor (HIF) pathway and cancer-suscep

212 ing and lipidomic profiling, we identify the hypoxia-inducible factor (HIF) pathway as a driver of th

213 and regulation is primarily performed by the hypoxia-inducible factor (HIF) pathway, and the key comp

214 This study compared effects of five hypoxia-inducible factor (HIF) prolyl hydroxylases (PHD)

215 , much research in this field has focused on hypoxia-inducible factor (HIF) signaling and reactive ox

216 Emerging evidence suggests that hypoxia-inducible factor (HIF) signaling plays a fundame

217 hown to promote breast cancer malignancy and hypoxia-inducible factor (HIF) stability.

218 Recruitment of RNA polymerase II to hypoxia-inducible factor (HIF) target genes under normox

219 s known to activate the transcription factor hypoxia-inducible factor (HIF) that increases lactate ef

220 d changes in gene expression are mediated by hypoxia-inducible factor (HIF) transcription factors tha

221 Oxygen regulates hypoxia-inducible factor (HIF) transcription factors to

222 nizes a field traditionally dominated by the hypoxia-inducible factor (HIF) transcriptional program.

223 demethylating RACK1 protein, a component of hypoxia-inducible factor (HIF) ubiquitination machinery,

224 specific prolyl and asparaginyl residues in hypoxia-inducible factor (HIF), a key transcription fact

225 n regulates cellular function is through the hypoxia-inducible factor (HIF), a transcription factor c

226 system include the transcriptional regulator hypoxia-inducible factor (HIF), which controls a wide ra

227 inal homeostasis is the transcription factor hypoxia-inducible factor (HIF), which is stabilized unde

228 Echinomycin, an inhibitor of hypoxia-inducible factor (HIF)-1 activity, was used to t

229 reprogramming and glucose uptake mediated by hypoxia-inducible factor (HIF)-1 alpha and glucose trans

230 mary endothelial cell-specific regulation of hypoxia-inducible factor (HIF)-1 and HIF-2 and their tar

231 Hypoxia-inducible factor (HIF)-1 mediates hypoxia- and c

232 factors GATA-binding protein 4 (GATA-4) and hypoxia-inducible factor (HIF)-1alpha and -2alpha in res

233 phages accumulate in hypoxic areas through a hypoxia-inducible factor (HIF)-1alpha dependent manner a

234 Under hypoxic conditions, stabilized hypoxia-inducible factor (HIF)-1alpha downregulates Daxx

235 r atpenin A5 in normoxia robustly stabilizes hypoxia-inducible factor (HIF)-1alpha in primary monocyt

236 was confirmed with histological staining for hypoxia-inducible factor (HIF)-1alpha, a cellular transc

237 found that burn injury activated mTORC1 and hypoxia-inducible factor (HIF)-1alpha, which paralleled

238 ROS have been shown to stabilize hypoxia-inducible factor (HIF)-1alpha, which, in turn, m

239 oxia-responsive master transcription factors hypoxia-inducible factor (HIF)-1alpha/2alpha, and their

240 ransduction is transcriptionally mediated by hypoxia-inducible factor (HIF).

241 We hypothesized that hypoxia-inducible factor (HIF)1alpha promotes proliferat

242 ding IL-1beta, and was dependent on mTOR and hypoxia-inducible factor (HIF)1alpha.

243 me of hypoxia-targeted therapeutics, such as hypoxia-inducible factor (HIF-1) inhibitors and hypoxia-

244 Mechanisms involved up-regulation of hypoxia-inducible factor (HIF-1alpha), its translocation

245 alysis identified specific binding sites for hypoxia-inducible factors (HIF) and TGF-beta1-activated

246 Hypoxia-inducible factors (HIF) are prominent among mech

247 of pVHL is to regulate the stability of the hypoxia-inducible factors (HIF), which become constituti

248 1), AMP-activated protein kinase (AMPK), and hypoxia-inducible factors (HIF-1alpha and HIF-2alpha)-ca

249 l transition (EMT) transcription factors and hypoxia-inducible-factor (HIF)-1 gene signature.

250 eased under hypoxic conditions and following hypoxia-inducible factor (HIF1) induction, suggesting th

251 or mTOR, NAD(+)-dependent deacetylase SIRT1, hypoxia-inducible factor HIF1alpha, oxidative stress-ind

252 ow the critical importance of high levels of hypoxia-inducible factor, HIF2alpha/EPAS1, and the nucle

253 Hypoxia inducible factor (HIFs) signaling contributes to

254 Hypoxia inducible factors (HIFs) are centrally involved

255 Hypoxia inducible factors (HIFs) are ubiquitously expres

256 which targets hydroxylated alpha subunit of hypoxia inducible factors (HIFs) for ubiquitination and

257 Hypoxia and hypoxia inducible factors (HIFs) play important roles in

258 ed mechanism of response to hypoxia involves hypoxia inducible factors (HIFs), which are stabilized b

259 As such as microRNA (miR)-210 that regulates hypoxia inducible factors (HIFs).

260 1), AMP-activated protein kinase (AMPK), and hypoxia inducible factors (HIFs; especially HIF-2alpha);

261 Hypoxia-inducible factors (HIFs) and the HIF-dependent c

262 tion in response to oxygen fluctuations, and hypoxia-inducible factors (HIFs) are central mediators o

263 Hypoxia-inducible factors (HIFs) are critical regulators

264 Hypoxia and stabilization of hypoxia-inducible factors (HIFs) are hallmark features o

265 in the VHL tumor suppressor stabilizing the hypoxia-inducible factors (HIFs) are the most prevalent

266 nsive changes in gene expression mediated by Hypoxia-Inducible Factors (HIFs) contribute significantl

267 a has been shown to up-regulate MALAT1, only hypoxia-inducible factors (HIFs) have been implicated in

268 esults in the constitutive activation of the hypoxia-inducible factors (HIFs) HIF-1 and HIF-2 and the

269 (PHD1 to PHD3) regulate the activity of the hypoxia-inducible factors (HIFs) HIF-1 and HIF-2, transc

270 This Review focuses on the role of hypoxia-inducible factors (HIFs) in hypertension, type 2

271 that APAP challenge caused stabilization of hypoxia-inducible factors (HIFs) in the liver and hepati

272 brafish that identifies GCs as activators of hypoxia-inducible factors (HIFs) in the liver.

273 oiesis and leukemogenesis are dependent upon hypoxia-inducible factors (HIFs), a family of essential

274 Hypoxia-inducible factors (HIFs), especially HIF-1alpha

275 l fatty acid (FA) transport, is repressed by hypoxia-inducible factors (HIFs), reducing FA oxidation

276 ecules including proteins that interact with hypoxia-inducible factors (HIFs), transcription factors

277 The response to hypoxia is mediated by hypoxia-inducible factors (HIFs).

278 ion of a transcriptional program mediated by hypoxia-inducible factors (HIFs).

279 maging probe, and analyzed the expression of hypoxia-inducible factors (HIFs).

280 ffected by pharmacological interference with hypoxia-inducible factors (HIFs).

281 en through transcriptional regulators called hypoxia-inducible factors (HIFs).

282 hypoxic regions in tumors and activation of hypoxia-inducible factors (HIFs).

283 oxia, a cellular adaptive response activates hypoxia-inducible factors (HIFs; HIF-1 and HIF-2) that r

284 , we report that hypoxia induces a rapid and hypoxia-inducible factor-independent induction of histon

285 ligand 26 production in cancer cells by the hypoxia-inducible factor inhibitor digoxin or blockade o

286 iological processes, including regulation of hypoxia-inducible factor-mediated adaptation to hypoxia,

287 In addition to collagen P4Hs and hypoxia-inducible factor P4Hs, a third P4H-the poorly ch

288 s transcription, distinct from the classical hypoxia-inducible factor pathway.

289 s of ion channels, as well as members of the hypoxia-inducible factors pathway.

290 A (protein phosphatase 2) regulates the HIF (hypoxia-inducible factor)/PHD-2 (prolyl hydroxylase 2)-c

291 The human hypoxia-inducible factor prolyl hydroxylase 2 (PHD2) rea

292 or other 2OG oxygenases, e.g. screens of the hypoxia-inducible factor prolyl-hydroxylase inhibitors r

293 in-5-yl}benzonitrile-based inhibitors of the hypoxia-inducible factor prolylhydroxylase domain-1 (PHD

294 with a focus on its relations with VEGF and hypoxia inducible factor related angiogenesis pathways,

295 hases cysl-1 and cysl-2 and the regulator of hypoxia inducible factor rhy-1 in progeny, and that thes

296 Hypoxia-inducible factor signalling appeared to mediate

297 caused by the hypoxic induction of the HIF (hypoxia-inducible factor) transcription factor or the 2-

298 Increased VE-PTP expression was dependent on hypoxia-inducible factor transcriptional activity in viv

299 Moreover, PHD2 knockdown can increase hypoxia-inducible factor/vascular endothelial protein ty

300 tress management is under the control of the Hypoxia Inducible Factors, whose activity depends on the