ライフサイエンスコーパス: hypoxia-inducible factor 1

1 regulated by the transcription factor HIF-1 (hypoxia-inducible factor 1).

2 regulates Complex II expression and opposes hypoxia-inducible factor-1.

3 sion is mediated by the transcription factor hypoxia-inducible factor-1.

4 lly mediated at the transcriptional level by hypoxia-inducible factor-1.

5 ontaining family, pyrin domain-containing-3; hypoxia-inducible factor 1/2alpha; and NF-kappaB were al

6 In this study, we demonstrate that hypoxia-inducible factor 1 activates the transcription o

7 phage glucose metabolism pathway via the Vpr-hypoxia inducible factor 1 alpha (HIF-1 alpha) axis to i

8 production of reactive oxygen species (ROS), hypoxia inducible factor 1 alpha (HIF-1alpha), and its t

9 mphedema, there is a significant increase of hypoxia inducible factor 1 alpha (HIF-1alpha), but a red

10 protein levels in macrophages and T cells of hypoxia inducible factor 1 alpha (HIF-1alpha), the regul

11 ovascular, resulting in the up-regulation of hypoxia inducible factor 1 alpha (HIF1A), which promotes

12 entified in this screen, only one candidate, hypoxia inducible factor 1 alpha (Hif1alpha), did not ha

13 from hydroxylating the transcription factor hypoxia inducible factor 1 alpha (HIF1alpha), targeting

14 The hypoxia inducible factor 1 alpha subunit (HIF1A) directl

15 found that E2 and PPT induced the binding of hypoxia inducible factor 1 alpha subunit (HIF1A) in the

16 ine production of VEGF with the induction of hypoxia inducible factor-1 alpha (HIF-1 alpha) and survi

17 control, and immunohistochemical staining of hypoxia inducible factor-1 alpha (HIF-1 alpha), vascular

18 of PI-3 kinase, reactive oxygen species and hypoxia inducible factor-1 alpha (HIF-1 alpha).

19 In parallel, hypoxia inducible factor-1 alpha (HIF-1alpha) activates

20 nd it was accompanied by decreased levels of hypoxia inducible factor-1 alpha (HIF-1alpha) and Bcl-2.

21 Given that both AR and hypoxia inducible factor-1 alpha (HIF-1alpha) are key re

22 poxia-inducible angiogenic pathway involving hypoxia inducible factor-1 alpha (HIF-1alpha), vascular

23 is reversed by allowing the stabilization of Hypoxia Inducible Factor-1 alpha (HIF-1alpha).

24 mpaired activity of the transcription factor hypoxia inducible factor-1 alpha (HIF-1alpha).

25 However, hypoxia inducible factor-1 alpha is naturally degraded b

26 trol, inhibition of PHD2 increased levels of hypoxia inducible factor-1 alpha protein and several dow

27 th shPHD2 had significantly higher levels of hypoxia inducible factor-1 alpha protein.

28 During hypoxia, upregulation of hypoxia inducible factor-1 alpha transcriptional factor

29 ationship for the VHL tumor suppressor gene, hypoxia inducible factor-1 alpha, and vascular endotheli

30 Hypoxia-inducible factor 1 alpha (HIF-1 alpha) is a prot

31 ngiogenic factors were partially mediated by hypoxia-inducible factor 1 alpha (HIF-1alpha) and recomb

32 Hypoxia-inducible factor 1 alpha (Hif-1alpha) is a neces

33 oenvironments where the stabilization of the hypoxia-inducible factor 1 alpha (Hif-1alpha) subunit is

34 posttranscriptional control of expression of hypoxia-inducible factor 1 alpha (HIF-1alpha), a critica

35 not only that LOXL2 was regulated by hypoxia/hypoxia-inducible factor 1 alpha (HIF-1alpha), but also

36 ial cells that have pathologic expression of hypoxia-inducible factor 1 alpha (HIF-1alpha).

37 ressed in neurons and is markedly induced by hypoxia-inducible factor 1 alpha (HIF-1alpha).

38 heckpoints, as well as impaired induction of hypoxia-inducible factor 1 alpha (HIF-1alpha).

39 Hypoxia-inducible factor 1 alpha (HIF1-alpha), which is

40 Hypoxia-inducible factor 1 alpha (HIF1alpha) is an essen

41 Levels of hypoxia-inducible factor 1 alpha (HIF1alpha) mRNA, a tar

42 sents a common pathway for the regulation of hypoxia-inducible factor 1 alpha (HIF1alpha)-dependent V

43 nd STAT6 phosphorylation, and down-regulated hypoxia-inducible factor 1 alpha and its downstream targ

44 activity associated with induction of tumor hypoxia-inducible factor 1 alpha expression and marked i

45 utyrate (SB) may indirectly (through reduced hypoxia-inducible factor 1 alpha stabilization) decrease

46 lower expression of lactate dehydrogenase 5, hypoxia-inducible factor 1 alpha subunit, and vascular e

47 activated phenotype (increased expression of hypoxia-inducible factor 1 alpha, glucose transporter 1,

48 ealed that mTOR controls the accumulation of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and the c

49 asts were hypersensitive to the induction of hypoxia-inducible factor-1 alpha (HIF-1 alpha) under hyp

50 EP1 receptor up-regulates the expression of hypoxia-inducible factor-1 alpha (HIF-1 alpha), which ca

51 ctly associated with a low oxygen responder, hypoxia-inducible factor-1 alpha (HIF-1 alpha).

52 hown to reduce oxidative stress and increase hypoxia-inducible factor-1 alpha (HIF-1alpha) activation

53 The protein stability of hypoxia-inducible factor-1 alpha (Hif-1alpha) and Hif-2a

54 eport that tamoxifen decreases the levels of hypoxia-inducible factor-1 alpha (HIF-1alpha) and the sy

55 ngiogenic effect, CSCs were transfected with hypoxia-inducible factor-1 alpha (HIF-1alpha) by using e

56 Hypoxia-inducible factor-1 alpha (HIF-1alpha) is an impo

57 Hypoxia-inducible factor-1 alpha (HIF-1alpha) is express

58 conditions, HEXIM1 inhibits estrogen-induced hypoxia-inducible factor-1 alpha (HIF-1alpha) protein ex

59 that robustly and persistently expresses the hypoxia-inducible factor-1 alpha (HIF-1alpha) therapeuti

60 ially via direct and indirect effects of the hypoxia-inducible factor-1 alpha (HIF-1alpha) transcript

61 ng that cetuximab reduces cellular levels of hypoxia-inducible factor-1 alpha (HIF-1alpha), a transcr

62 hypoxic/ischemic retinal ganglion cells in a hypoxia-inducible factor-1 alpha (HIF-1alpha)-dependent

63 se inhibitors (PHI) promote stabilization of hypoxia-inducible factor-1 alpha and affect signaling ca

64 allogeneic recipients resulted in increased hypoxia-inducible factor-1 alpha expression and reduced

65 pimonidazole, macrophage marker RAM-11, and hypoxia-inducible factor-1 alpha subunit [HIF-1alpha]).

66 e B), SRC, and overexpression of HIF1-alpha (hypoxia-inducible factor-1 alpha), survivin, and VWF (Vo

67 ding IGF1, B cell CLL/lymphoma 2 (BCL2), and hypoxia inducible factor 1, alpha subunit (HIF1A).

68 ion by phosphorylation of Akt, which induces hypoxia inducible factor 1-alpha (HIF-1alpha).

69 , vascular endothelial growth factor (VEGF), hypoxia-inducible factor 1-alpha (HIF-1alpha) and erythr

70 that the expression of NLRP3 is mediated by hypoxia-inducible factor 1-alpha (HIF-1alpha) during the

71 s to test whether constitutive expression of hypoxia-inducible factor 1-alpha (HIF-1alpha) influences

72 a mutated (ATM)-dependent phosphorylation of hypoxia-inducible factor 1-alpha (HIF-1alpha) on serine(

73 The hypoxia-inducible factor 1-alpha (HIF-1alpha), a key pla

74 in physiological oxygen conditions through a hypoxia-inducible factor 1-alpha (HIF-1alpha)-dependent

75 NAT1 deletion also up-regulated hypoxia-inducible factor 1-alpha (HIF1-alpha).

76 We demonstrate that hypoxia-inducible factor 1-alpha (HIF1A) inhibition in l

77 miR-210 transcription was activated in an hypoxia-inducible factor 1-alpha (Hif1a)-dependent manne

78 nsiently increasing the transcription factor hypoxia-inducible factor 1-alpha (HIF1alpha) is required

79 mutant mice did not display accumulation of hypoxia-inducible factor 1-alpha (HIF1alpha), and deleti

80 and c-MYC protein levels as well as elevated hypoxia-inducible factor 1-alpha activity.

81 1, and the downstream transcription factors hypoxia-inducible factor 1-alpha and c-Myc, which togeth

82 was associated with increased expression of hypoxia-inducible factor 1-alpha and glucose transporter

83 ation and decreased nuclear translocation of hypoxia-inducible factor 1-alpha and vascular endothelia

84 TLR-primed cells was dependent, in part, on hypoxia-inducible factor 1-alpha and was essential for i

85 e kinase release spectrophotometrically, and hypoxia-inducible factor 1-alpha by Western blotting.

86 Increased hypoxia-inducible factor 1-alpha expression in the MP gr

87 Importantly, both VHL and the hypoxia-inducible factor 1-alpha gene are experimentally

88 tors nuclear factor of activated T cells and hypoxia-inducible factor 1-alpha in PAH-PASMCs, previous

89 Expression of hypoxia-inducible factor 1-alpha peaked in the SCS-group

90 Mechanistically, 1,25-VitD3 increased hypoxia-inducible factor 1-alpha through binding to its

91 Hypoxia-inducible factor 1-alpha was elevated but not ma

92 Hypoxia-regulated hypoxia-inducible factor 1-alpha, (HIF-1alpha) may regul

93 y, Leu increases the intracellular levels of hypoxia-inducible factor 1-alpha, a repressor of endocri

94 eration, up-regulation of AKT signaling, and hypoxia-inducible factor 1-alpha-related angiogenesis.

95 ys and knockout and inhibitory strategies of hypoxia-inducible factor 1-alpha.

96 04, nuclear factor of activated T cells, and hypoxia-inducible factor 1-alpha.

97 ngiopoietin-1, matrix metalloprotease-2, and hypoxia-inducible factor 1-alpha.

98 ered to express tumor-necrosis-factor-alpha, hypoxia-inducible-factor-1-alpha antibodies, interleukin

99 d stress-induced activation of cardiomyocyte hypoxia inducible factor 1 and the release of vascular e

100 Results show accumulation of hypoxia inducible factors 1 and 2alpha (HIF-1 and 2alpha

101 rect transcriptional target of oxygen-labile hypoxia-inducible factor 1 and 2 that accentuates the fo

102 expression of their transcriptional factors hypoxia-inducible factor-1 and c-Myc.

103 owth factor (VEGF) and blocked activation of hypoxia-inducible factor-1 and nuclear factor-kappaB in

104 E were dependent on the transcription factor hypoxia-inducible factor-1 and on formation of a single-

105 Hypoxia-inducible factors 1 and 2 (HIF-1 and -2) control

106 Hypoxia, via the hypoxia-inducible factors 1 and 2 (HIF-1 and HIF-2), upr

107 Hypoxia-inducible factors 1 and 2 (HIF-1 and HIF-2, resp

108 Hypoxia-inducible factors 1 and 2 (HIF1 and HIF2) are he

109 Hypoxia-inducible factors 1 and 2 constitute important c

110 ated their ability to respond to hypoxia via hypoxia-inducible factors 1 and 2, tumor relapse was una

111 up-regulating such transcription factors as hypoxia-inducible factors 1 and 2, which in turn activat

112 We found that wild-type p53 and hypoxia-inducible factor 1 co-regulate hDBR1 expression,

113 2 (A2) gene through the direct action of the hypoxia-inducible factor-1 complex.

114 Hypoxia-inducible factor-1 directly regulated TrkB expre

115 ith higher VEGF (3.65 vs. 5.98; P = 0.01) or hypoxia-inducible factor 1 expression (3.63 vs. 5.48; P

116 glucose transporter protein 1 (Glut-1), and hypoxia-inducible factor 1 expression.

117 ar endothelial growth factor but upregulated hypoxia-inducible factor 1 expression.

118 ntly, we demonstrated that factor-inhibiting hypoxia-inducible factor 1 (FIH-1) diminished glycogen s

119 dies with the hydroxylase, factor inhibiting hypoxia-inducible factor 1 (FIH-1), we observed increase

120 n undergo hydroxylation by factor-inhibiting hypoxia-inducible factor 1 (FIH-1); however, the biologi

121 Factor inhibiting hypoxia-inducible factor 1 (FIH-1; official symbol HIF1A

122 iRNA, negatively regulates factor inhibiting hypoxia-inducible factor-1 (FIH-1).

123 poxic human cells requires the activation of hypoxia inducible factor 1 (HIF-1) and not HIF-2.

124 Hypoxia inducible factor 1 (HIF-1) is a key player in ca

125 Hypoxia inducible factor 1 (HIF-1) up-regulates the expr

126 full expression of the transcription factor hypoxia inducible factor 1 (HIF-1).

127 lpha (AMPKalpha) degradation, (ii) increased hypoxia inducible factor-1 (HIF-1) alpha expression, and

128 ators have been identified for its promoter: hypoxia inducible factor-1 (HIF-1) and signal transducer

129 nical data provides evidence for the role of hypoxia inducible factor-1 (HIF-1) as a crucial mediator

130 Hypoxia inducible factor-1 (HIF-1) initiates key cellula

131 Hypoxia inducible factor-1 (HIF-1) is a heterodimeric tr

132 Hypoxia inducible factor-1 (HIF-1) is a master regulator

133 with tumor resistance to therapy and express hypoxia inducible factor-1 (HIF-1), a transcription fact

134 The transcription factor, hypoxia inducible factor-1 (HIF-1), plays a significant

135 Overexpression of hypoxia inducible factor-1 (HIF-1)alpha, which is common

136 activated mTORC1 and downstream upregulated hypoxia inducible factor-1 (HIF-1alpha) expression.

137 Hypoxia-inducible factor 1 (HIF-1) activates transcripti

138 Tumor hypoxia and hypoxia-inducible factor 1 (HIF-1) activation are associ

139 irst marine natural product shown to inhibit hypoxia-inducible factor 1 (HIF-1) activation.

140 alpha-ketoglutarate antagonist that induces hypoxia-inducible factor 1 (HIF-1) activity, results in

141 Hypoxia-inducible factor 1 (HIF-1) and activator protein

142 ugh activation of transcription factors like hypoxia-inducible factor 1 (HIF-1) and c-Myc, yet the im

143 Hypoxia activates hypoxia-inducible factor 1 (HIF-1) and induces autocrine

144 Hilpda proved to be a target of hypoxia-inducible factor 1 (Hif-1) and peroxisome prolif

145 ROS production, we showed that ROS regulated hypoxia-inducible factor 1 (HIF-1) and vascular endothel

146 Here, we confirmed the presence of a hypoxia-inducible factor 1 (HIF-1) binding site within t

147 We tested the hypothesis that hypoxia-inducible factor 1 (HIF-1) expression, an O(2)-s

148 response to hypoxia in many cell types, and hypoxia-inducible factor 1 (HIF-1) has been implicated i

149 Hypoxia-inducible factor 1 (HIF-1) has been recognized a

150 Hypoxia-inducible factor 1 (HIF-1) has been suggested to

151 Stabilization of the hypoxia-inducible factor 1 (HIF-1) increases life span a

152 rus encoding a constitutively active form of hypoxia-inducible factor 1 (HIF-1) induced VEGFR1 mRNA a

153 Hypoxia-inducible factor 1 (HIF-1) is a central regulato

154 Here, we demonstrate that hypoxia-inducible factor 1 (HIF-1) is a critical regulat

155 Here, we demonstrate that hypoxia-inducible factor 1 (HIF-1) is a critical regulat

156 Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric tr

157 Hypoxia-inducible factor 1 (HIF-1) is a master regulator

158 Hypoxia-inducible factor 1 (HIF-1) is a master regulator

159 Hypoxia-inducible factor 1 (HIF-1) is a master transcrip

160 Hypoxia-inducible factor 1 (HIF-1) is a master transcrip

161 Hypoxia-inducible factor 1 (HIF-1) is a transcription fa

162 Hypoxia-inducible factor 1 (HIF-1) is a transcription fa

163 Hypoxia-inducible factor 1 (HIF-1) is a transcription fa

164 Hypoxia-inducible factor 1 (HIF-1) is a transcription fa

165 Hypoxia-inducible factor 1 (HIF-1) is a transcription fa

166 Hypoxia-inducible factor 1 (HIF-1) is a transcription fa

167 Hypoxia-inducible factor 1 (HIF-1) is a ubiquitously exp

168 recent work delineating mechanisms by which hypoxia-inducible factor 1 (HIF-1) mediates adaptive met

169 Here we report that the hypoxia-inducible factor 1 (HIF-1) pathway is establishe

170 The transcription factor Hypoxia-inducible factor 1 (HIF-1) plays a central role

171 We recently showed that hypoxia-inducible factor 1 (HIF-1) plays a crucial role

172 The transcription factor hypoxia-inducible factor 1 (HIF-1) plays a pivotal role

173 Hypoxia-inducible factor 1 (HIF-1) plays a role in tumou

174 Being key regulator of oxygen homeostasis hypoxia-inducible factor 1 (HIF-1) plays significant rol

175 y demonstrated that the transcription factor hypoxia-inducible factor 1 (HIF-1) promotes the onset of

176 der conditions of reduced O(2) availability, hypoxia-inducible factor 1 (HIF-1) reciprocally regulate

177 Here we show that hypoxia-inducible Factor 1 (HIF-1) regulates allelic var

178 Hypoxia-inducible factor 1 (HIF-1) regulates transcripti

179 r concentrations of thioredoxin 1 (Trx1) and hypoxia-inducible factor 1 (HIF-1) than cells from unsup

180 Here, we delineate a pathway controlled by hypoxia-inducible factor 1 (HIF-1) that epigenetically a

181 EN increases the transcriptional activity of hypoxia-inducible factor 1 (HIF-1) through the inactivat

182 ated, our results point to the activation of hypoxia-inducible factor 1 (HIF-1) upon HIV-1 infection

183 Numerous studies link activation of hypoxia-inducible factor 1 (HIF-1) with tumor angiogenes

184 uestion and reveal that orexin activates the hypoxia-inducible factor 1 (HIF-1), a heterodimeric tran

185 Here, we show that hypoxia-inducible factor 1 (HIF-1), a key metabolic sens

186 Factor inhibiting hypoxia-inducible factor 1 (HIF-1), FIH1, is derepressed

187 ia-induced amoeboid detachment was driven by hypoxia-inducible factor 1 (HIF-1), followed the downreg

188 ons requires transcription through activated hypoxia-inducible factor 1 (HIF-1), increased mRNA stabi

189 adhesion molecule 1, IL-10, heme oxygenase 1 hypoxia-inducible factor 1 (HIF-1), monocyte chemotactic

190 g the relationship between the activation of hypoxia-inducible factor 1 (HIF-1), the primary transcri

191 Transcriptional activity of hypoxia-inducible factor 1 (HIF-1), which drives VEGF ex

192 rs increased production of erythropoietin by hypoxia-inducible factor 1 (HIF-1), which is a transcrip

193 A low dose of either H2S or HCN can activate hypoxia-inducible factor 1 (HIF-1), which is required fo

194 hypoxic pulmonary hypertension (HPH) include hypoxia-inducible factor 1 (HIF-1)-dependent transactiva

195 cin and daunorubicin as potent inhibitors of hypoxia-inducible factor 1 (HIF-1)-mediated gene transcr

196 Metformin also reduced hypoxic activation of hypoxia-inducible factor 1 (HIF-1).

197 that PKM2 gene transcription is activated by hypoxia-inducible factor 1 (HIF-1).

198 oxygen-sensitive master transcription factor hypoxia-inducible factor 1 (HIF-1).

199 poxia) is the regulation of transcription by hypoxia-inducible factor 1 (HIF-1).

200 d transcriptional response driven largely by hypoxia-inducible factor 1 (HIF-1).

201 s have demonstrated that copper up-regulates hypoxia-inducible factor 1 (HIF-1).

202 trials or use was screened for inhibitors of hypoxia-inducible factor 1 (HIF-1).

203 effects of hypoxia also were independent of hypoxia-inducible factor 1 (HIF-1).

204 es the induction of the transcription factor hypoxia-inducible factor 1 (HIF-1).

205 ed in ischemic brain preconditioning (PC) by hypoxia-inducible factor 1 (HIF-1).

206 ion regulates glycolysis in cancer cells via hypoxia-inducible factor 1 (HIF-1alpha) and its transcri

207 own-regulated sFlt1 production by inhibiting hypoxia-inducible factor 1 (HIF-1alpha) protein expressi

208 Hypoxia-inducible factor-1 (Hif-1) and Hif-2 are key med

209 Here, we report that balanced activity of hypoxia-inducible factor-1 (HIF-1) and HIF-2 is critical

210 of the KRAS mutations and for expression of hypoxia-inducible factor-1 (HIF-1) and minichromosome ma

211 The hypoxia-inducible factor-1 (HIF-1) binding site located

212 In this report, we address the dynamics of hypoxia-inducible factor-1 (HIF-1) binding to the vascul

213 Hypoxia-inducible factor-1 (HIF-1) can activate expressi

214 We further demonstrate that the hypoxia-inducible factor-1 (HIF-1) constitutes an import

215 of this study was to establish the effect of hypoxia-inducible factor-1 (HIF-1) directly on tumor gro

216 Hypoxia-inducible factor-1 (HIF-1) has been suggested to

217 to accumulation of the transcription factor hypoxia-inducible factor-1 (HIF-1) in skeletal muscle ce

218 (NF-kappaB), activator protein-1 (AP-1), and hypoxia-inducible factor-1 (HIF-1) in the hypoxic regula

219 Here we report that 1 h of HT activates hypoxia-inducible factor-1 (HIF-1) in tumors and its dow

220 Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric tr

221 Hypoxia-inducible factor-1 (HIF-1) is a key gene regulat

222 Hypoxia-inducible factor-1 (HIF-1) is a known cancer pro

223 Hypoxia-inducible factor-1 (HIF-1) is a primary regulato

224 Hypoxia-inducible factor-1 (HIF-1) is a transcription fa

225 Hypoxia-inducible factor-1 (HIF-1) is a transcription fa

226 Hypoxia-inducible factor-1 (HIF-1) is a transcription fa

227 Hypoxia-inducible factor-1 (HIF-1) is a well-studied tra

228 a potent stimulator of VEGF expression, and hypoxia-inducible factor-1 (HIF-1) is considered to be c

229 Hypoxia-inducible factor-1 (HIF-1) is the master regulat

230 The transcriptional activator hypoxia-inducible factor-1 (HIF-1) mediates a broad rang

231 and inhibition of tumor angiogenesis via the hypoxia-inducible factor-1 (HIF-1) pathway.

232 Hypoxia-inducible factor-1 (HIF-1) plays a central role

233 Hypoxia-inducible factor-1 (HIF-1) plays an essential ro

234 However, Pdcd4 did not affect hypoxia-inducible factor-1 (HIF-1) protein expression or

235 Hypoxia-inducible factor-1 (HIF-1) regulates the transcr

236 The transcription factor hypoxia-inducible factor-1 (HIF-1) represents an importa

237 Hypoxia-inducible factor-1 (HIF-1) stabilization is a pi

238 o hypoxia, characterized by the induction of hypoxia-inducible factor-1 (HIF-1) target genes.

239 ated during hypoxia due to direct binding by hypoxia-inducible factor-1 (HIF-1) to HIF-1 response ele

240 LOX in colorectal cancer synergizes with hypoxia-inducible factor-1 (HIF-1) to promote tumor prog

241 ion of gene expression occurs mainly via the hypoxia-inducible factor-1 (HIF-1) transcription factor

242 rubicin (DXR) and daunorubicin (DNR) inhibit hypoxia-inducible factor-1 (HIF-1) transcriptional activ

243 Digoxin and other cardiac glycosides inhibit hypoxia-inducible factor-1 (HIF-1) transcriptional activ

244 the effects of pharmacological inhibition of hypoxia-inducible factor-1 (HIF-1), a critical regulator

245 To examine the role of hypoxia-inducible factor-1 (HIF-1), a key mediator of ce

246 These tumor cells are hypoxic and express hypoxia-inducible factor-1 (HIF-1), a prosurvival transc

247 rimary factor mediating this response is the hypoxia-inducible factor-1 (HIF-1), an oxygen-sensitive

248 -kappaB), STAT3, activator protein-1 (AP-1), hypoxia-inducible factor-1 (HIF-1), and tumor protein 53

249 suppresses hypoxia-sensitive genes, e.g. via hypoxia-inducible factor-1 (HIF-1), but mutations in Com

250 ecular key players in tumor hypoxia, such as hypoxia-inducible factor-1 (HIF-1), have been discovered

251 cellular response, the transcription factor hypoxia-inducible factor-1 (HIF-1), is correlated with p

252 bunit of the host cell transcription factor, hypoxia-inducible factor-1 (HIF-1), is up-regulated by i

253 tivation in transcription are dependent upon hypoxia-inducible factor-1 (HIF-1), whereas others are H

254 y and voltage dependency as full-length, was hypoxia-inducible factor-1 (HIF-1)-dependent and could b

255 Hypoxia-induced angiogenesis is mediated by hypoxia-inducible factor-1 (HIF-1)-dependent transcripti

256 suppressor (VHL), which negatively regulates hypoxia-inducible factor-1 (HIF-1).

257 o hypoxia respond by increasing the level of hypoxia-inducible factor-1 (HIF-1).

258 The primary mediating factor is the hypoxia-inducible factor-1 (HIF-1).

259 to be regulated by the transcription factor hypoxia-inducible factor-1 (HIF-1).

260 nds the functional NF-kappaB binding site in hypoxia-inducible factor-1 (HIF-1alpha) promoter and res

261 Exposure to SB also suppressed hypoxia-inducible factor-1 (HIF-1alpha) stabilization an

262 tidinyl hydroxylase FIH-1 (factor inhibiting hypoxia-inducible factor 1 [HIF-1]), the lysyl hydroxyla

263 alt chloride (CoCl(2), a chemical inducer of hypoxia-inducible factor 1, HIF-1), suggesting a regulat

264 elanoma and clear cell sarcoma cells through hypoxia inducible factor 1 (HIF1)-mediated induction of

265 form the heterodimeric transcription factor hypoxia inducible factor 1 (HIF1).

266 nts by activating the transcription factors, hypoxia-inducible factor 1 (HIF1) and HIF2.

267 The transcription factor hypoxia-inducible factor 1 (HIF1) facilitates the induct

268 The role of hypoxia and hypoxia-inducible factor 1 (HIF1) in the development of

269 Hypoxia-inducible factor 1 (HIF1) is a heterodimeric tra

270 Hypoxia-inducible factor 1 (HIF1) is up-regulated in mos

271 is increased by pharmacologic inhibition of hypoxia-inducible factor 1 (HIF1) or its target gene pyr

272 family of transcription factors, among which hypoxia-inducible factor 1 (HIF1) plays a major role.

273 In exercise, as well as cancer and ischemia, hypoxia-inducible factor 1 (HIF1) transcriptionally acti

274 the metabolic reprogramming associated with hypoxia-inducible factor 1 (HIF1), as constitutive activ

275 cancer cells was under strict control of the hypoxia-inducible factor 1 (HIF1), which drove redox- an

276 phorylation of Akt followed by activation of hypoxia-inducible factor 1 (HIF1).

277 ssor VHL, driving constitutive activation of hypoxia-inducible factor-1 (HIF1) and HIF2.

278 Hypoxia-inducible factor-1 (HIF1) is a transcription fac

279 Hypoxia-inducible factor-1 (HIF1), the master regulator

280 ic breast cancer cells through the action of hypoxia-inducible factor-1 (HIF1).

281 n of TIGAR depended on mitochondrial HK2 and hypoxia-inducible factor 1 (HIF1alpha) activity.

282 ption, lactate production, and expression of Hypoxia-inducible factor 1 (HIF1alpha) target genes, sug

283 label exchange between pyruvate and lactate, hypoxia-inducible factor-1 (HIF1alpha), and the monocarb

284 by an oxygen-sensitive transcription factor, hypoxia-inducible factor-1 (HIF1alpha), which becomes ac

285 ilization of the transcription factor HIF-1 (hypoxia-inducible factor 1) in neurons and muscle.

286 cIH induced systemic insulin resistance in a hypoxia-inducible factor 1-independent manner and impair

287 P=9.8x10(-10)) and HIF1AN (factor inhibiting hypoxia-inducible factor-1; P=5.7x10(-9)) polymorphisms

288 oxide dismutase (SOD2), increases HIF1alpha (hypoxia-inducible factor-1), reduces endothelial cadheri

289 dermal growth factor receptor-MAP/ERK kinase-hypoxia-inducible factor 1 signaling but on RhoA pathway

290 The hypoxia-inducible factor 1 signaling pathway was enriche

291 cation arrest and is entirely independent of hypoxia-inducible factor 1 status.

292 he stricture phenotype of ISMC showed stable hypoxia inducible factor 1 subunit alpha expression that

293 phenotypic markers, and stable expression of hypoxia inducible factor 1 subunit alpha.

294 g axis towards glycolysis with activation of hypoxia-inducible factor 1 subunit alpha (HIF-1alpha) an

295 We measured levels and stability of the hypoxia-inducible factor 1 subunit alpha (HIF1A), endoth

296 t of a transcriptional complex involving the hypoxia-inducible factor-1 transcription factor, p300, R

297 d by mTORC1 regulate the expression of HIF1 (hypoxia-inducible factor 1) transcription factor complex

298 y foci, evidencing induction of an epidermal hypoxia-inducible factor-1 transcriptional program, and

299 Another trophic factor regulated by hypoxia-inducible factor-1, vascular endothelial growth

300 f asTF is mediated via the activation of the hypoxia-inducible factor-1/vascular endothelial growth f