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1 s C and cooling compounds such as menthol or icilin.
2 al compounds such as the supercooling agent, icilin.
3 ng oppose the behavioral stimulant effect of icilin.
4 incidence of shaking elicited by 2.5mg/kg of icilin.
5 d and chemical agonists, such as menthol and icilin.
6  activated by the cooling agents menthol and icilin.
7  agents and known TRPM8 agonists menthol and icilin.
8 10-200microM) nor intrathecal application of icilin (0.1nM to 1microM) affected tactile allodynia or
9                           Rats injected with icilin (0.5, 1, 2.5, 5mg/kg, i.p.) displayed dose-relate
10 nhanced the shaking induced by a low dose of icilin (0.5mg/kg).
11                                              Icilin (10 nM-10 microM) produced a concentration-relate
12 educed dose dependently (0.002-200microM) by icilin (18-80%).
13                               The effects of icilin, a TRPM8 and TRPA1 agonist, on intracellular Ca(2
14                                 In contrast, icilin activates TRPM8 with extremely variable latency f
15      TRPM8 channel behavior upon menthol and icilin activation was distinguishable, and the effect of
16 ly increased by ENaC delta subunit agonists (icilin and capsazepine).
17  residue (L1008), but was independent of the icilin and menthol binding site residue Y745 and, essent
18 eptor activation inhibits shaking induced by icilin and that increases in peripheral, as well as cent
19 tures and cooling agents such as menthol and icilin and these channels are tightly regulated by the m
20 8 degrees C) and cooling compounds (menthol, icilin) and are implicated in sensing unpleasant cold st
21  a wide range of stimuli, including menthol, icilin, and cold temperatures (<25 degrees C).
22 , inhibited the activation of TRPM8 by cold, icilin, and menthol.
23 so lack behavioral response to cold-inducing icilin application and display an attenuated response to
24 (DRG) neurons, and the analgesic efficacy of icilin applied topically to the paws or intrathecally wa
25 t study was to investigate the usefulness of icilin as a pharmacological tool to study primary affere
26 tivation of TRPM4 by icilin, suggesting that icilin binds to the cooling agent binding pocket to prom
27                 Further, TRPM8 activation by icilin blocked capsaicin-triggered calcitonin-gene-relat
28 ation was distinguishable, and the effect of icilin depended on the presence of calcium on the intrac
29                    Intraplantar injection of icilin did not evoke firing of WDR neurones in naive, sh
30 .) and 2-BFI (7 mg/kg, i.p.), did not affect icilin-evoked shaking.
31 TRPV1 agonist capsaicin or the TRPM8 agonist icilin had no effect on intracellular Ca(2+) concentrati
32 o and to investigate the analgesic effect of icilin in a neuropathic pain model in vivo.
33 ntial mechanism for the analgesic effects of icilin in other pain models.
34 he modulation of ICa(V) by the TRPM8-agonist icilin in vitro and to investigate the analgesic effect
35                                              Icilin increased both innocuous (sham-operated and SNL r
36                Bryostatins 1 and 3 inhibited icilin-induced calcium flux in HEK-293 cells overexpress
37 etrahydrothienopyridine 4 as an inhibitor of icilin-induced calcium influx in CHO cells expressing re
38 deficiencies in certain behaviors, including icilin-induced jumping and cold sensation, as well as a
39                         We conclude that the icilin-induced modulation of ICa(V) in DRG neurons is un
40 31a showed significant target coverage in an icilin-induced WDS (at 11.5 mg/kg ip), an oxaliplatin-in
41 at alpha(2)-adrenoceptor activation inhibits icilin-induced WDS.
42 pecific in vivo coverage models in rats (the icilin-induced wet dog shake model and the cold pressor
43 acodynamic model measuring the prevention of icilin-induced wet-dog shakes (WDS).
44                                              Icilin is a transient receptor potential cation channel
45         The vigorous shaking associated with icilin is dependent on NMDA receptor activation and nitr
46 nk with the channel activity, sensitivity to icilin, menthol and cold, and impact on channel oligomer
47           We then show how the cooling agent icilin modulates activation of mouse TRPM4 to intracellu
48                       Our data suggests that icilin modulates the mechanosensitivity of dorsal horn n
49             The differing effects of ice and icilin on dorsal horn neurones indicate different mechan
50                               The effects of icilin on ICa(V) were not significantly different in non
51  complex with the synthetic cooling compound icilin, PIP(2), and Ca(2+), as well as in complex with t
52 ere, we show that, to achieve full efficacy, icilin requires simultaneous elevation of cytosolic Ca2+
53                              Determinants of icilin sensitivity map to a region of TRPM8 that corresp
54 treated systemically with the TRPM8 agonist, icilin showed an attenuation of chemically induced colit
55 gents similarly alter activation of TRPM4 by icilin, suggesting that icilin binds to the cooling agen
56                                 Furthermore, icilin treatment reduced the 2,4,6-trinitrobenzenesulfon
57                   Menthol (TRPM8-Y745H)- and icilin (TRPM8-N799A)-insensitive mutants were also activ
58 ehavior caused by a fixed dose (2.5mg/kg) of icilin was also inhibited in a dose-related manner by cl
59      TRPM8 responses to cold and the agonist icilin were abolished by inhibitors of the calcium-indep