ライフサイエンスコーパス: idiotypic

1 The possibility that the anti-idiotypic 6A6 might carry an "internal image" of the ori

2 The findings suggest that anti-idiotypic Ab responses can be induced by T cell vaccinat

3 cause all of the variants that arise in anti-idiotypic Ab-treated lymphoma patients remain BCR positi

4 ficacy, and abolished recognition by an anti-idiotypic Ab.

5 he present study, we observed that some anti-idiotypic Ab2beta antibodies inhibited dopamine uptake b

6 in our laboratory have produced several anti-idiotypic Ab2beta antibodies that mimic the configuratio

7 r the first time that B cells producing anti-idiotypic Abs could be isolated from vaccinated patients

8 hilia and systemic lupus erythematosus, anti-idiotypic Abs counteracting and neutralizing pathogenic

9 ity pattern, and the regulatory role of anti-idiotypic Abs elicited by T cell vaccination in patients

10 We hypothesized that some anti-idiotypic Abs function as divalent molecular mimics of s

11 abs by phage display to explore whether anti-idiotypic Abs have a role in iTTP.

12 th mAb and in active immunotherapy with anti-idiotypic Abs mimicking the CO17-1A or GA733 epitope.

13 typic humoral responses and whether the anti-idiotypic Abs play a similar role in the regulatory mech

14 The resulting anti-idiotypic Abs were found to react with the original immu

15 Anti-idiotypic Abs were undetectable in animals vaccinated wi

16 by immunization with the protein alone, anti-idiotypic Abs, or irradiated tumor cells.

17 ctionality of ITIM+ FcgammaR, effective anti-idiotypic and antitumoral immunity can be achieved by Fc

18 1 TCB (Prot-FOLR1-TCB) equipped with an anti-idiotypic anti-CD3 mask connected to the anti-CD3 Fab th

19 se-cleavage of the linker releasing the anti-idiotypic anti-CD3 scFv.

20 upon repeated i.p. dosing because of an anti-idiotypic anti-drug Ab immune response.

21 Three of eight participants showed a non-idiotypic anti-drug antibody (ADA) response directed aga

22 MELIMMUNE, a combination of the murine anti-idiotypic (anti-id) monoclonal antibodies (mAb) MEL-2 an

23 antigen (HMW-MAA) mimicry by the mouse anti-idiotypic (anti-id) monoclonal antibody (mAb) MK2-23.

24 nked immunosorbent assays (ELISAs) with anti-idiotypic antibodies (anti-IDs) targeting the variable r

25 ated with GAD65-specific mAbs to absorb anti-idiotypic antibodies (anti-Ids).

26 if these IgG-inhibitory antibodies are anti-idiotypic antibodies (anti-Ids).

27 to the autoantigen, which then induces anti-idiotypic antibodies (autoantibodies) that cross-react w

28 We produced rabbit anti-idiotypic antibodies against two pathogenic and two non-

29 diated protection in this assay include anti-idiotypic antibodies and downregulation of complement ac

30 matoid factors, in which they represent anti-idiotypic antibodies directed against antibodies to bact

31 Antigen mimicry of using anti-idiotypic antibodies for use as cancer vaccines has been

32 ripheral anionic site, since polyclonal anti-idiotypic antibodies generated against two monoclonal an

33 In addition, high levels of VRC07-523 anti-idiotypic antibodies in the circulation of one newborn w

34 Anti-idiotypic antibodies provide precision tools for analyzi

35 The anti-idiotypic antibodies recognized both the erythrocyte bin

36 avenous gammaglobulin (i.v.IG) contains anti-idiotypic antibodies that are potent inhibitors of HLA-s

37 This antibody response elicits anti-idiotypic antibodies that cross-react with ANCA antigens

38 Anti-idiotypic antibodies were detected in only 6 of 24 patie

39 gion-specific antibodies and select for anti-idiotypic antibodies with specificity for the unique var

40 rocess manifested through production of anti-idiotypic antibodies with tobacco-like activity.

41 and production of cytokines, providing anti-idiotypic antibodies, and affecting the activation and e

42 n of a putative auxin receptor by using anti-idiotypic antibodies.

43 kers may be driven, in part, by tobacco anti-idiotypic antibodies.

44 A monoclonal anti-idiotypic antibody (anti-Id) to the chlamydial exoglycol

45 Here, we characterize how an anti-idiotypic antibody (E1) binds antibody HM14c10, which po

46 Anti-DNA idiotypic antibody activity was studied in 3 preparation

47 d immuno-enrichment with a biotinylated anti-idiotypic antibody and streptavidin magnetic beads.

48 ing and flow cytometry using a specific anti-idiotypic antibody called E4, which recognizes this cano

49 ummary, the results demonstrate that an anti-idiotypic antibody can specifically recognize and expand

50 Thus, all detectable anti-DNA idiotypic antibody capable of blocking SLE anti-DNA comb

51 A mouse monoclonal anti-idiotypic antibody directed against the polyphenol-react

52 By the final visit, median anti-anti-idiotypic antibody level was 493,000.0 ng/mL, indicating

53 d was not associated with any increased anti-idiotypic antibody production.

54 Low levels of serum anti-idiotypic antibody remained unaltered in recipients of T

55 arrier proteins or adjuvants induces an anti-idiotypic antibody response.

56 al factor for PRRSV infection using the anti-idiotypic antibody specific to the PRRSV glycoprotein GP

57 use of purified viral gB protein and an anti-idiotypic antibody that mimics the image of the viral gH

58 e-labeled immunohistochemically with an anti-idiotypic antibody that recognizes 5-HT1B, 5-HT2A, and 5

59 such as recombinant target antigen and anti-idiotypic antibody, are not available, measuring mouse s

60 ach to expand specific B cells using an anti-idiotypic antibody, iv8, that selects for naive human B

61 After priming by CSC or tobacco anti-idiotypic antibody, there was a 2.5-fold to threefold in

62 purified neutrophils and CSC or tobacco anti-idiotypic antibody.

63 We showed previously using lymphoma-derived idiotypic antigen that exposure to "helpless" antigen si

64 utated lineage-specific antigens and mutated idiotypic antigens may be coexpressed by tumor cells, th

65 We implement these anti-idiotypic aptamers as bioreceptors in graphene-based fie

66 haracteristic of antibodies participating in idiotypic cascades.

67 autoimmune diseases caused by the failure of idiotypic control of autoreactive B cells.

68 as dsRNA, overcomes suboptimal responses to idiotypic determinants and may constitute a novel approa

69 gical malignancy, we show that Ig-associated idiotypic determinants are recognized by the immune syst

70 hat immunization with DNA, which encodes the idiotypic determinants of a B cell lymphoma, generates t

71 The idiotypic determinants of B cell lymphoma provide a tumo

72 Idiotypic determinants of the immunoglobulin expressed o

73 he relationship between self and non-self or idiotypic determinants on therapeutic antibodies and the

74 The study was undertaken to define the idiotypic determinants responsible for triggering CD8+ c

75 was sustained by reactivity of its BCR to an idiotypic epitope in its own V region.

76 sRNA, correcting the ineffective response to idiotypic epitopes.

77 ously uncharacterized contributions of L2 to idiotypic expression.

78 a cells and analyzed for Ars binding and for idiotypic expression.

79 We obtained 27 single anti-idiotypic Fab clones, half of which had unique sequences

80 its/ml, or 1-2 Bethesda units/ml), with anti-idiotypic Fab pools neutralized functional ADAMTS13 inhi

81 Anti-idiotypic Fab pools of both patients fully neutralized t

82 of intermediate affinity belongs to the same idiotypic family as 4-4-20 and shares substantial amino

83 nown whether T cell vaccination elicits anti-idiotypic humoral responses and whether the anti-idiotyp

84 rstanding of the regulatory role of the anti-idiotypic humoral responses induced by T cell vaccinatio

85 By using a safe idiotypic (Id) antigen from a B cell tumor fused to a fr

86 V region-derived idiotypic (Id) peptides can be displayed as pId:MHCII co

87 lymphoma patients immunized with autologous idiotypic ig molecules for changes in tumor-specific cyt

88 ymphoma who received an antitumor vaccine of idiotypic ig protein showed humoral and proliferative im

89 We selected and amplified the splenic anti-idiotypic IgG<sub>1</sub> Fab kappa/lambda r

90 present evidence for the presence of an anti-idiotypic immune response in iTTP patients.

91 on platelet count are not likely due to anti-idiotypic inhibition of 7E3-platelet binding and that IV

92 here peptide mimics of PC based on the anti-idiotypic interaction of T15 anti-PC antibodies.

93 Idiotypic interactions may be a factor in the selection

94 beta-defensins or selected chemokines to an idiotypic lymphoma antigen has yielded potent antitumor

95 lf-interaction of Fab fragments of anti-anti-idiotypic mAb GH1002 through their combining sites is ex

96 tive specific immunization regimens (an anti-idiotypic mAb immunization protocol (mAb-keyhole limpet

97 shown to be almost as specific as a private idiotypic MAb in identifying T cell clones.

98 In a phase I/II clinical trial, anti-idiotypic mAb MK2-23, conjugated to keyhole limpet hemoc

99 this idea, we studied two well-defined anti-idiotypic mAbs, T10-505 and T10-938, elicited in syngene

100 Expression of cross-reactive idiotypic markers found on human anti-MCPS antibodies in

101 sking the anti-CD3 Fab fragment with an anti-idiotypic mask and cleavage of the mask by tumor-specifi

102 Using gene-targeted mice, we show that anti-idiotypic MHC class I-restricted immunity is promoted by

103 e of the Fab fragment of the mouse anti-anti-idiotypic monoclonal antibody (mAb) GH1002 was solved by

104 pression, we have used as immunogen the anti-idiotypic monoclonal antibody (mAb) MK2-23, which mimics

105 shed light on the mechanisms regulating the idiotypic network and managing the diversity associated

106 ve immunity to p53 can be induced through an idiotypic network by immunization of mice with a monoclo

107 he manner in which affinity is defined in an idiotypic network model imposes a definite topology on t

108 Idiotypic network models give one possible justification

109 ts of the generation of secondary responses, idiotypic network regulation, and isotype function.

110 opology on the connectivity of the potential idiotypic network that can emerge.

111 Simulations of an evolving idiotypic network where new clones are introduced on a d

112 of tumour antigens, or by triggering of the idiotypic network.

113 rnover of individual clones, indicating that idiotypic networks possess self-organizing properties.

114 ically discrete modules receiving input from idiotypic olfactory sensory neurons.

115 that predispose their carriers to late-onset idiotypic Parkinson's disease (PD) and also to autoimmun

116 et transfusion refractoriness) the causative idiotypic platelet-reactive antibodies have to be detect

117 Multiple myeloma (MM) cells express idiotypic proteins and other tumor-associated antigens w

118 Anti-idiotypic reagents were used to detect V(H)1, V(H)3, and

119 implications in our understanding of in vivo idiotypic regulation of autoimmune T cells and the regul

120 -3 and cPR-3 bound to each other, indicating idiotypic relationships.

121 cterize potentially protective reagents, the idiotypic repertoire of human antibodies to cryptococcal

122 kade strategy obviates possibilities of anti-idiotypic responses that could potentially limit the eff

123 rated that a fusion protein consisting of an idiotypic single chain Fv antibody fragment (scFv) linke

124 tem allowed rapid production and recovery of idiotypic single-chain antibodies (scFv) derived from ea

125 demonstrate that M167 B cell receptor (BCR) idiotypic-specific B cells are first selected within the

126 tide inserts that bind with high avidity and idiotypic specificity to the selecting mAbs.

127 Although the idiotypic structures of immunoglobulin from malignant B

128 tive T cell clones were used to isolate anti-idiotypic T cell lines from immunized MS patients.

129 that CDR3-specific T cells represented anti-idiotypic T cell population induced by T cell vaccinatio

130 sponsible for triggering CD8+ cytotoxic anti-idiotypic T cell responses by T cell vaccination in pati

131 ve T cells (T cell vaccination) induces anti-idiotypic T cell responses that preferentially recognize

132 ve T cells (T cell vaccination) induces anti-idiotypic T cell responses that suppress circulating MBP

133 ion and important targets for cross-reactive idiotypic therapy.