1 oxifene, 4-hydroxytamoxifen, nafoxidine, and
idoxifene.
2 A series of homologs of
idoxifene [
1a, (E)-1-[4-(N-pyrrolidinoethoxy)phenyl]-1-(
3 week, which was maintained for 3 months with
idoxifene (
3.1 versus 0.48% compared to E2 controls) but
4 ioanalytical method for the determination of
idoxifene,
a selective estrogen receptor modulator, and
5 Idoxifene also inhibits calmodulin, a calcium-binding pr
6 The LOQ obtained was 10 ng/mL for
idoxifene and 30 ng/mL for the metabolite.
7 t method was applied to the determination of
idoxifene and its metabolite in clinical human plasma sa
8 mn temperatures to perform LC separations of
idoxifene and its metabolite within 10 s/sample.
9 internal standard, the results obtained for
idoxifene and tamoxifen satisfy current bioanalytical me
10 Both
idoxifene and tamoxifen significantly inhibited E2-depen
11 In this study, the abilities of
idoxifene and tamoxifen to antagonize E2-dependent MCF-7
12 lower relative binding affinity for ER than
idoxifene but similar calmodulin-inhibitory activity.
13 ed to a greater extent following 3 months of
idoxifene,
compared to tamoxifen.
14 Using
idoxifene-
d5 as an internal standard, idoxifene showed a
15 Using
idoxifene-
d5 as an internal standard, the results obtain
16 bited E2-dependent tumor growth, whereas cis-
idoxifene had little effect.
17 In contrast, cis-
idoxifene had no effect on either cell proliferation or
18 Idoxifene (
ID) is a tissue-selective estrogen receptor m
19 Both tamoxifen and
idoxifene initially induced ER expression, whereas prolo
20 Idoxifene is a novel selective estrogen (E2) receptor (E
21 Compared to tamoxifen,
idoxifene is metabolically more stable, with a higher re
22 f hormonal therapy with a SERM (tamoxifen or
idoxifene)
or an aromatase inhibitor (anastrozole or vor
23 cation was 5 and 50 ng/ mL for tamoxifen and
idoxifene,
respectively.
24 In conclusion,
idoxifene resulted in similar inhibition of E2-dependent
25 The basis for
idoxifene'
s antitumor activity was examined by comparing
26 Using idoxifene-d5 as an internal standard,
idoxifene showed acceptable accuracy and precision value
27 Idoxifene showed acceptable results with accuracy rangin
28 ically used transisomer (referred to here as
idoxifene)
with its cis-isomer, which has a 50-fold lowe