ライフサイエンスコーパス: imaginal

1 h prolonged exposure therapy, which includes imaginal and in vivo exposure to anxiety-provoking stimu

2 cific antibodies showed losses of Nopp140 in imaginal and polyploid tissues.

3 ion of several chemosensory-related genes in imaginal bugs, while both sexes had similar expression p

4 deling at metamorphosis involves a classical imaginal cell population and a population of differentia

5 ing larval feeding rates, protein synthesis, imaginal cell size, and control of molting.

6 Imaginal cells are specified in the embryo and remain qu

7 uch as Drosophila are generated by groups of imaginal cells dedicated to the formation of different o

8 Pupal and adult tissues form from imaginal cells, tissue-specific progenitors allocated in

9 tarsal-less is required for embryonic and imaginal development in Drosophila, but the molecular an

10 Second, loss of Upd3 during imaginal development results in defects of adult structu

11 ssues [5, 6] or transplantation of a damaged imaginal disc [7, 8] delays the onset of metamorphosis.

12 both cases, the epidermal tissue of the wing imaginal disc acts as a niche expressing the ligands Ser

13 ligands, Gbb and Dpp, to patterning the wing imaginal disc along its A/P axis, change as a function o

14 onditionally ablate patches of tissue in the imaginal disc and assess the ability of the surviving si

15 other developing epithelia, such as the wing imaginal disc and the embryonic germband in Drosophila,

16 hogenetic furrow, that sweeps across the eye imaginal disc and transforms thousands of undifferentiat

17 h factor (FGF) proteins produced by the wing imaginal disc and transported by cytonemes to the air sa

18 t specifically reduced misfolded Rh-1 in the imaginal disc assay also delayed age-related retinal deg

19 ed a glycolytic tumor in the Drosophila wing imaginal disc by activating the oncogene PDGF/VEGF-recep

20 y member Dpp is produced in a limited set of imaginal disc cells and functions as a classic morphogen

21 In homozygous E(z) mutants, imaginal disc cells are smaller than cells in normally p

22 larity gene scribble in clones of Drosophila imaginal disc cells can cooperate with Ras signaling to

23 In Drosophila, damaged imaginal disc cells can induce the proliferation of neig

24 y (CLPs) able to induce the proliferation of imaginal disc cells in vitro.

25 Imaginal disc cells mutant for the tumor-suppressor gene

26 In imaginal disc cells mutant for Vps4, EGFR and other rece

27 Previous studies have shown that imaginal disc cells that are mutant for TSC have increas

28 We find that after IR, p53 is required for imaginal disc cells to repair DNA, and in its absence th

29 14 kb upstream of the bantam hairpin in eye imaginal disc cells, arguing that this regulation is dir

30 preferentially localizes to the membrane of imaginal disc cells.

31 ay modulate Hippo transcriptional effects in imaginal disc cells.

32 Using an ex vivo imaginal disc culture system, we showed that mitotically

33 ental checkpoint extends larval growth after imaginal disc damage by inhibiting the transcription of

34 Imaginal disc damage inflicted early in larval developme

35 While most previous analyses of imaginal disc development have not distinguished between

36 Imaginal disc development in Drosophila requires coordin

37 Fas2 is expressed in dynamic patterns during imaginal disc development, and in the eye we have shown

38 l genes and genetic pathways involved in leg imaginal disc development, we employed a Genome Wide Ass

39 dMyc in this process during Drosophila wing imaginal disc development.

40 for both viability and the initial stages of imaginal disc development.

41 ene expression patterns observed during wing imaginal disc development.

42 e Drosophila YAP homolog Yorkie (Yki) during imaginal disc development.

43 of founder cells that give rise to the wing-imaginal disc during normal development and following co

44 ng element is required for the action of the imaginal disc enhancer(s).

45 The imaginal disc epithelia that give rise to the adult ecto

46 -suppressor genes (nTSGs) in Drosophila wing imaginal disc epithelia that tumor initiation depends on

47 suppressor genes that regulate the growth of imaginal disc epithelia.

48 Finally, loss of Wts in Drosophila imaginal disc epithelial cells results in diminished cor

49 In the growing Drosophila wing imaginal disc epithelium, most of the cell divisions in

50 sequestering Hedgehog protein signal within imaginal disc epithelium.

51 Drosophila imaginal disc growth factor 2 (IDGF2) is a member of chi

52 ess of EpiTools by analyzing Drosophila wing imaginal disc growth, revealing previously overlooked pr

53 xpected requirement for the miRNA pathway in imaginal disc growth.

54 ila larvae by inducing apoptosis in the wing imaginal disc in a spatially and temporally regulated ma

55 tion (smFISH) for use in the Drosophila wing imaginal disc in order to measure nascent and mature mRN

56 tion needed to transform a relatively simple imaginal disc into a more complex and three-dimensional

57 The division of the wing imaginal disc into anterior, posterior, dorsal, and vent

58 Following segregation of the Drosophila wing imaginal disc into dorsal (D) and ventral (V) compartmen

59 The Drosophila wing imaginal disc is subdivided along the proximodistal axis

60 Overexpression of AR2 in wing imaginal disc is sufficient to cause notched wing margin

61 t expressed until differentiation in the eye imaginal disc it was more easily trans-inactivated than

62 Using the wing imaginal disc model in Drosophila, we identified new SMO

63 The Drosophila larval eye-antennal imaginal disc must be subdivided into regions that diffe

64 ne expression analyses of the larval genital imaginal disc of D. mauritiana, D. sechellia, and two D.

65 Ptip (Paxip1) gene in early development and imaginal disc patterning.

66 Here we show that the small imaginal disc phenotype arises, at least in part, from a

67 The Drosophila leg imaginal disc provides a paradigm with which to understa

68 The Drosophila wing imaginal disc provides a powerful system with which to u

69 In Drosophila, imaginal disc regeneration can be induced either by frag

70 Here we test the role of Sp1 during imaginal disc regeneration.

71 Thor gene in E(z) mutants partially restores imaginal disc size toward wild-type and results in an in

72 nduction of apoptosis in the Drosophila wing imaginal disc stimulates activation of the Hippo pathway

73 re types of filopodia in the Drosophila wing imaginal disc that are proposed to serve as conduits in

74 gnaling in the region of the Drosophila wing imaginal disc that produces Hh and is near the tracheal

75 ell fate specification in the Drosophila eye imaginal disc using fibrillarin antibody labeling.

76 sues where Ubx is active (third thoracic leg imaginal disc) but is not bound in tissues where the Ubx

77 he Ubx gene is repressed (first thoracic leg imaginal disc).

78 To study this question the Drosophila wing imaginal disc, an epithelial primordial organ that later

79 etic furrow sweeps anteriorly across the eye imaginal disc, driven by Hedgehog secretion from photore

80 In the Drosophila wing imaginal disc, dying cells trigger compensatory prolifer

81 nder cells specified in the mesothoracic leg imaginal disc, we also demonstrate that the TGFbeta path

82 Using Drosophila wing imaginal disc, we demonstrate that Sfrp3 functions as an

83 m, the embryonic nervous system and the wing imaginal disc, we show that Flybow in conjunction with s

84 ferentially expressed in the Drosophila wing imaginal disc, which gives rise to two distinct adult st

85 In the Drosophila eye imaginal disc, Wingless (Wg) signaling defines the regio

86 Most remarkable is that imaginal disc-derived lines can generally be assigned, o

87 ol of epithelial integrity in the Drosophila imaginal disc.

88 regulates folds within the third instar wing imaginal disc.

89 g of wg and hth expression levels in the eye imaginal disc.

90 nit (RnrL) reduce compensatory growth in the imaginal disc.

91 elopment of the Drosophila melanogaster wing imaginal disc.

92 C1 double null clones in the Drosophila wing imaginal disc.

93 ly enhance robustness in the Drosophila wing imaginal disc.

94 Branchless FGF-expressing cells in the wing imaginal disc.

95 itted progenitor cells of the Drosophila eye imaginal disc.

96 ence that the DVM FCs may arise from the leg imaginal disc.

97 s enriched in the dorsal portion of the wing imaginal disc.

98 te bone morphogenetic protein) from the wing imaginal disc.

99 a single larval structure, the eye-antennal imaginal disc.

100 crete subpopulation of cells within the wing imaginal disc.

101 ling the formation of SOPs in the adult wing imaginal disc.

102 e embryonic head and developing eye-antennal imaginal disc.

103 ferentially expressed in the Drosophila wing imaginal disc.

104 r/posterior compartment boundary of the wing imaginal disc.

105 lium is essential for patterning of the wing imaginal disc.

106 tations that impair regeneration in the wing imaginal disc.

107 rogenitor cells develop together in the wing imaginal disc.

108 dentified the Trithorax group protein Little imaginal discs (Lid) as a regulator of dMyc-induced cell

109 brid screens to identify a protein, tumorous imaginal discs (Tid1), that binds to the cytoplasmic dom

110 mammalian homolog of the Drosophila tumorous imaginal discs (Tid1).

111 n ligase, cause dramatic loss of polarity in imaginal discs accompanied by tumorous proliferation def

112 rder cells or proneural clusters of the wing imaginal discs affects DRONC-dependent patterning.

113 Genetic evidence in the developing eye imaginal discs also demonstrates the critical functions

114 lly activate PI(3)K signalling in Dp110(RBD) imaginal discs and Dp110(RBD) flies are small.

115 ling pathway functions to suppress growth in imaginal discs and has been suggested to control organ s

116 rs, including the histone demethylase little imaginal discs and histone-interacting protein p55, that

117 derably reduces toxic mHtt aggregates in eye imaginal discs and partially restores rhabdomere morphol

118 When all cells in imaginal discs are mutant for scrib, they hyperactivate

119 Hippo pathway components in Drosophila wing imaginal discs are organized into distinct junctional co

120 cle and cell growth control using Drosophila imaginal discs as a genetically accessible system.

121 Using Drosophila imaginal discs as an in vivo model, we show that Wts, bu

122 d-type Rh-1 were overexpressed in developing imaginal discs beyond the ER protein folding capacity of

123 in damaged and regenerating Drosophila wing imaginal discs but that is dispensable for these fates i

124 We propose that p53 maintains plasticity of imaginal discs by co-regulating the maintenance of genom

125 patterns the embryonic epidermis and larval imaginal discs by regulating the transcription factor, C

126 Drosophila melanogaster larval imaginal discs can recover from extensive damage, produc

127 , many cells in the posterior regions of eye imaginal discs carrying a double knockdown of Mcm10 and

128 tion is dramatically increased in lgl larval imaginal discs compared to both wild type and brat mutan

129 AGO1 depletion in wing imaginal discs drives a significant increase in ribosome

130 Damage to Drosophila imaginal discs elicits a robust regenerative response fr

131 Without juvenile hormone, imaginal discs form and grow despite severe starvation.

132 inal discs in mid-third instar larvae, since imaginal discs from larvae with reduced or no ecdysone s

133 lesser extent, Ds suppress overgrowth of the imaginal discs from which appendages develop and regulat

134 Specification and development of Drosophila imaginal discs have been studied for many years as model

135 onset of metamorphosis are regulated by the imaginal discs in Drosophila, and suggest that the termi

136 es, Hippo and Warts, restricts the growth of imaginal discs in Drosophila.

137 s of GFP-expressing salivary glands and wing imaginal discs in living Drosophila melanogaster pupae i

138 we show that ecdysone promotes the growth of imaginal discs in mid-third instar larvae, since imagina

139 The evagination of Drosophila imaginal discs is a classic system for studying tissue l

140 upation phenotype seen when a single pair of imaginal discs is homozygous for a neoplastic TSG mutati

141 Loss of ESCRT function in Drosophila imaginal discs is known to cause neoplastic overgrowth f

142 t the initial ato transcription in different imaginal discs is regulated by distinct 3' cis-regulator

143 The initial expression of ato in imaginal discs is regulated by sequences that lie 3' to

144 Car for late endosome-to-lysosome fusion in imaginal discs is specific as early endosomes are unaffe

145 show that damage to, or slow growth of, the imaginal discs is sufficient to retard metamorphosis bot

146 t the normal role of this exoribonuclease in imaginal discs is to suppress the expression of transcri

147 Expression of BID in eye imaginal discs leads to a rough-eye phenotype, and this

148 Like tissues of many organisms, Drosophila imaginal discs lose the ability to regenerate as they ma

149 Regeneration of fragmented Drosophila imaginal discs occurs in an epimorphic manner involving

150 hat IR-induced apoptosis still occurs in the imaginal discs of chk2 and p53 mutant larvae, albeit wit

151 The imaginal discs of Drosophila are subdivided into distinc

152 The imaginal discs of Drosophila are the larval primordia fo

153 Imaginal discs of Drosophila have the remarkable ability

154 The imaginal discs of Drosophila melanogaster provide a part

155 ion under physiological conditions using the imaginal discs of Drosophila.

156 anscriptional profiling of dissected genital imaginal discs of each sex at three time points during e

157 la melanogaster, IR induces apoptosis in the imaginal discs of larvae, typically assayed at 4-6 hr af

158 RNA and 4E-BP protein levels are elevated in imaginal discs of PRC2 subunit mutant larvae.

159 The larval imaginal discs of the genetically tractable model organi

160 ytoneme modulation was recapitulated in wing imaginal discs of transgenic Drosophila, providing evide

161 The study of regeneration in Drosophila imaginal discs provides an opportunity to use powerful g

162 gaster Live imaging of single DSBs in larval imaginal discs recapitulates the spatio-temporal dynamic

163 Damaged Drosophila imaginal discs regenerate efficiently early in the third

164 of aveugle mutant cells in the eye and wing imaginal discs resemble those caused by reduction of EGF

165 -epsilon or sgg/gsk3beta in Drosophila wing imaginal discs results in the accumulation of dMyc prote

166 that kill about half of the cells in larval imaginal discs still develop into viable adults.

167 ansmission electron microscopy (TEM) on wing imaginal discs temporally depleted of the ESCRT-III core

168 model ("undead" model) in larval Drosophila imaginal discs that are attached by numerous macrophages

169 ecified during embryogenesis and, unlike the imaginal discs that make up the thoracic and head segmen

170 We show that in imaginal discs the single Drosophila STAT protein (STAT9

171 In Drosophila imaginal discs these processes are coordinated by the st

172 also contribute to cell segregation in wing imaginal discs through an unknown mechanism independent

173 ous, induced strong overgrowth in Drosophila imaginal discs through modulating the activity of the Hi

174 e microdissection from Drosophila larval eye imaginal discs to identify FoxO targets that restrict th

175 Ft also inhibits the overgrowth of imaginal discs via the Hippo pathway, repressing the act

176 , ecdysone appears to regulate the growth of imaginal discs via Thor/4E-BP, a negative growth regulat

177 sine-specific demethylase 1) and Lid (little imaginal discs), demethylate histone H3 at Lys 4 (H3K4),

178 eveloping and intact epithelium ( Drosophila imaginal discs), wherein cell-cell adhesion properties a

179 la, null mutations in pacman result in small imaginal discs, a delay in onset of pupariation and leth

180 teristic of Hh signaling loss in embryos and imaginal discs, and epistasis analysis places ihog actio

181 modulator of Hippo pathway activity in wing imaginal discs, and implicate Yorkie activation in compe

182 ua (Cic) restricts cell growth in Drosophila imaginal discs, and its levels are, in turn, downregulat

183 ate that the developing adult organs, called imaginal discs, are a regulator of critical size in larv

184 replication and proliferation in brains and imaginal discs, as well as for gene amplification in ova

185 regulates Dpp and Notch signaling in larval imaginal discs, at least partially via regulation of thi

186 d activate transcription in embryos and wing imaginal discs, but it is no longer processed into the r

187 The Thor gene is normally repressed in imaginal discs, but Thor mRNA and 4E-BP protein levels a

188 In wing imaginal discs, CKI loss leads to elevated Expanded and

189 f adult structures through expression in all imaginal discs, driven by enhancers from the 3' cis-regu

190 ecapentaplegic (Dpp) pattern Drosophila wing imaginal discs, establishing gene expression boundaries

191 In mosaic Drosophila imaginal discs, for example, wild-type cells induce the

192 t Drosophila melanogaster body develops from imaginal discs, groups of cells set-aside during embryog

193 uction is essential for proliferation of the imaginal discs, in part, by regulating JAK/STAT signalin

194 Imaginal discs, like appendages in lower vertebrates, in

195 rmis and other larval organs, including gut, imaginal discs, neurons, fat body, tracheae, muscles and

196 Drosophila, including controlling growth of imaginal discs, planar cell polarity (PCP) and the proxi

197 (c) Diffuse damage to imaginal discs, results in compensatory proliferation of

198 etic circuits tumors depend on because their imaginal discs, simple epithelia present in the larva, c

199 nonoverlapping patterns in both embryos and imaginal discs, suggesting that transcription of these n

200 In epithelial cells of Drosophila imaginal discs, the Caspase-9 ortholog Dronc drives AiP

201 2 mutants show impaired development of their imaginal discs, the primordial tissues that form the adu

202 Thus, in Drosophila eye imaginal discs, Trr, likely functioning together with Ut

203 mitotic cell junction dynamics in Drosophila imaginal discs, we mathematically predict the convergenc

204 stat92E is active ubiquitously in early wing imaginal discs, where it acts to inhibit the induction o

205 required for development of the wing and leg imaginal discs, whereas cleavage at the S1 site is suffi

206 Drosophila adult structures derive from imaginal discs, which are sacs with apposed epithelial s

207 including upregulation of the same genes in imaginal discs, which suggests that Sbb cooperates with

208 sophila, the adult wing is derived from wing imaginal discs, which undergo a period of growth and pro

209 ation along the basal surface of larval wing imaginal discs, which was restored with wild type pgant3

210 In the mosaic eye imaginal discs, while ph(del), a null allele, causes onl

211 suppressed dMYC-dependent overgrowth of wing imaginal discs.

212 hough more restricted, results in the larval imaginal discs.

213 (SAC) genes and preventing apoptosis in wing imaginal discs.

214 silencing, some PcG mutants also have small imaginal discs.

215 ibble (scrib) are eliminated from Drosophila imaginal discs.

216 in every segment boundary within the larval imaginal discs.

217 for confocal microscopy images of Drosophila imaginal discs.

218 een reported to be a survival factor in wing imaginal discs.

219 texts; for example, in the wing, leg and eye imaginal discs.

220 cell proliferation and promotes apoptosis in imaginal discs.

221 ession domain of homothorax (hth) in the leg imaginal discs.

222 leg regeneration in fragments of Drosophila imaginal discs.

223 -induced p53-independent apoptosis in larval imaginal discs.

224 nt Crumbs (Crb) affects growth in Drosophila imaginal discs.

225 ss of Crb similarly results in overgrowth of imaginal discs.

226 phila Schneider line 2 (S2) cells and larval imaginal discs.

227 dispensable in primary epithelia such as the imaginal discs.

228 ious reports in the ovary, early embryo, and imaginal discs.

229 direct targets of PcG-mediated repression in imaginal discs.

230 rior compartment boundary of Drosophila wing imaginal discs.

231 it was rescued by expression of nito in wing imaginal discs.

232 the Ultrabithorax (Ubx) gene in larval wing imaginal discs.

233 e mutants and disproportionate growth of the imaginal discs.

234 d/or Phol for binding to the bxd PRE in wing imaginal discs.

235 is deregulated in rbf mutant cells in larval imaginal discs.

236 eded to limit IR-induced apoptosis in larval imaginal discs.

237 arge cohort of miRNAs expressed primarily in imaginal discs.

238 the pathway by which Ras regulates growth in imaginal discs.

239 entially expressed genes in wing and haltere imaginal discs.

240 en signaling in Drosophila melanogaster wing imaginal discs.

241 on and hyperplastic overgrowth of Drosophila imaginal discs.

242 ila, and fat mutants have severely overgrown imaginal discs.

243 NA-mediated translational repression in wing imaginal discs.

244 gene expression, cell affinity and growth in imaginal discs.

245 4 endogenously tagged TFs in live Drosophila imaginal discs.

246 he transcription activation by Trl in larval imaginal discs.

247 se-dependent Hh signaling in Drosophila wing imaginal discs.

248 in, in contrast to epithelial tissues of the imaginal discs.

249 the progression of S phase in Drosophila eye imaginal discs.

250 uses abnormal epithelial cysts in Drosophila imaginal discs.

251 h for mRNAs misregulated in pacman null wing imaginal discs.

252 n long-range Hh signaling in Drosophila wing imaginal discs.

253 apoptosis in surface epithelia of Drosophila imaginal discs.

254 e pattern and growth by diffusing throughout imaginal discs.

255 ell-cell adhesion in shaping Drosophila wing imaginal discs.

256 al size or the state of development of their imaginal discs.

257 t translational repression in developing eye imaginal discs; (2) in dendritic elaboration of larval s

258 ression of an active form of Msn in the wing imaginal disk disrupted activation of endogenous MAD by

259 stribution in the developing Drosophila wing imaginal disk does not adapt to disk size.

260 slocalization of Ex to basolateral domain of imaginal disk epithelial cells.

261 reports, that they have additive effects on imaginal disk growth and development.

262 reparation for metamorphosis, the control of imaginal disk growth becomes feeding and nutrition-indep

263 n upstream component of the Hippo pathway in imaginal disk growth control.

264 ral other chitinase-like proteins, including imaginal disk growth factor IDGF2.

265 Here, we use the wing imaginal disk of Drosophila as a model to examine the fu

266 producing inositide messengers required for imaginal disk tissue maturation and subsequent formation

267 ct synergistically to modulate growth of the imaginal disk.

268 ision and the duration of growth of the wing imaginal disks depend on the size of the body in which t

269 arval feeding period, the growth of the wing imaginal disks of Lepidoptera is dependent on continuous

270 Growth of the wing imaginal disks of non-feeding wandering stage Manduca se

271 ndages develop from precursor tissues called imaginal disks that grow after somatic growth has ceased

272 gene transcription in developing Drosophila imaginal disks.

273 In Drosophila imaginal epithelia, clones of cells mutant for tumor sup

274 to restrict cell proliferation in developing imaginal epithelia.

275 egulate proliferation and differentiation in imaginal epithelia.

276 assembly after DNA replication, in the wing imaginal epithelium leads to increased Hippo pathway tar

277 ssing of traumatic material, and in vivo and imaginal exposure homework.

278 ted of modified prolonged exposure including imaginal exposure to the trauma memory, processing of tr

279 ns that included cognitive restructuring and imaginal exposure were the most effective for reducing P

280 ovel insight into the hormonal regulation of imaginal growth.

281 ein depletion>95 correlated with the loss of imaginal island (precursor) cells in the larval midgut a

282 inal larval (fifth) instar of Manduca sexta, imaginal precursors including wing discs and eye primord

283 as a metamorphosis-initiating factor in the imaginal precursors.

284 ollaboration required between linguistic and imaginal processing in this task would be underserved in

285 a transition zone between the salivary gland imaginal ring cells and the giant cells in Drosophila la

286 esis, whereas the rest of the salivary gland imaginal ring is refractory to Notch-induced tumor trans

287 Hedgehog signaling in the imaginal sensory organ precursors thus confers different

288 In this study, using Drosophila imaginal tissue as an in vivo model system, we show that

289 In contrast, complete removal of all imaginal tissue has no effect on critical size.

290 e spider Antp gene in Drosophila embryos and imaginal tissue that this unique function of Antp is not

291 t cause pronounced hyperproliferation of eye imaginal tissue, accompanied by deregulation of epitheli

292 ects have demonstrated that either damage to imaginal tissues [5, 6] or transplantation of a damaged

293 acco hornworm moth Manduca sexta, larval and imaginal tissues stop growing, the former because they l

294 totic recombination in developing Drosophila imaginal tissues to analyze the behavior of cells devoid

295 ecific growth trajectories of larval but not imaginal tissues.

296 igate division orientation in the Drosophila imaginal wing disc epithelium.

297 , as employed to study the Drosophila larval imaginal wing disc, the precursor of the adult wing.

298 he anterior/posterior boundary of the larval imaginal wing disc.

299 roliferation, and survival in the developing imaginal wing disc.

300 herited through successive cell divisions in imaginal wing discs.