ライフサイエンスコーパス: immature

1 k component is capable of addressing remains immature.

2 defects introduced by these variants remains immature.

3 promotes courtship in mature (7-day) but not immature (2-day) males; this behavioral plasticity requi

4 ult spinal cord, functionally resembling the immature active-stem cell niche of neonatal animals.

5 ic function, the absence of which results in immature afferent processing and a hypofunctional state.

6 with severe acute malnutrition (SAM) display immature, altered gut microbiota and have a high mortali

7 Immatures always performed a trans-equatorial migration

8 e Ad5-VII- map, density corresponding to the immature amino-terminal region of VI indicates that in t

9 ammatory response differ greatly between the immature and adult brain.

10 pioni et al. (2019) tracked the migration of immature and breeding Cory's shearwaters and found that

11 hat the disorganized arrangement of dyads in immature and failing cells promoted desynchronized and s

12 rophils from reproductive-age males are more immature and less activated than their female counterpar

13 and unveil their differential requirement in immature and mature B lymphocytes.

14 We reveal novel sub-types of immature and mature gammadelta T cells and identify an u

15 Immature and mature hepatocytes were characterized by he

16 taining lateral links to the cytoskeleton in immature and mature stereocilia.

17 el iPSC-CM phenotypes, as shown by comparing immature and mature subpopulations of models to analyse

18 We performed electron tomography (ET) of immature and mature Ty3 particles within cells.

19 filtrating ARG1-expressing cells were mainly immature and monocytic MDSCs, which provides information

20 ells despite normal tolerance checkpoints in immature and naive B cells of lupus-prone MRL/lpr and NZ

21 Immature and naive T cells are present in both healthy a

22 cted mice are reduced in numbers and have an immature and partially activated phenotype but do respon

23 he greatest impact on behavior when they are immature and plastic.

24 chronically infected with CL13, NK cells are immature and residually activated, and following ECTV in

25 /or spleen and inhibited maturation of pre-, immature, and transitional stage 2 B cells.

26 Reduced IL-1beta production in immature animals provides a mechanism permitting asthma

27 results suggest that the MOC-OHC synapse is immature at the onset of hearing.SIGNIFICANCE STATEMENT

28 ta for the analysis of overall survival were immature at the time of the primary analysis.

29 Here, we tagged 103 immature Australasian white sharks (147-350 cm fork leng

30 characterisation of the movement ecology of immature Australasian white sharks across multiple spati

31 w pro-B and pre-B cells and decreases at the immature B cell stage.

32 CD43(+)CD24(+)CD5(+)), and higher numbers of immature B cells (IgD(dim)IgM(dim)CD21(neg)) at the expe

33 entation in both DCs and B cells, especially immature B cells and thus has the potential to produce a

34 In the former, immature B cells did not develop and in the latter CD34+

35 Analysis of antigen-specific immature B cells in early and late ontogeny identified L

36 mics of bone marrow-derived CD34+ cells into immature B cells in vitro allowed us to distinguish pati

37 romoted spontaneous death of pre-B cells and immature B cells in vitro.

38 the number of regulatory T (Treg) cells and immature B cells was increased, by IL-17 deficiency in R

39 en directs the development of small pre- and immature B cells, including orchestrating cell cycle exi

40 ased BCR editing and developmental arrest of immature B cells, resulting in reduced peripheral B cell

41 onsequence of the chemical composition of an immature bean.

42 Quaker beans from precursors present in raw immature beans.

43 involves the hierarchical differentiation of immature blast cells into mature, functional cell types

44 d, PMO10-29 appears to more readily cross an immature blood-brain barrier following systemic administ

45 Immature bracts (C1: principal growth stage (PGS) 5) had

46 period for thalamic network stabilization in immature brain remains unclear.

47 Smad4 loss of function in immature bVSNs compromises dendritic knob formation, phe

48 st that assembly via a structurally distinct immature capsid is a later retroviral adaptation, while

49 Cryo-EM reconstructions for the mature and immature capsids at 3.7- angstrom and 4.4- angstrom reso

50 the capacity to induce a trabecular fate in immature cardiomyocytes in vitro, and the ability to und

51 We identify immature cardiomyocytes that enter the cell cycle follow

52 s but increases after injury, resembling the immature CC.

53 tive phenotype were largely contained within immature CD24(+)CD73(-) and CD24(+)CD73(+) subsets, wher

54 we show that DN T cells transit through the immature CD4(+)CD8(+) (double-positive) thymocyte stage.

55 during T cell development, and is limited to immature CD4(-)CD8(-) thymocytes.

56 Here we observed that Mycl is expressed in immature cDC1s but repressed on maturation, concomitant

57 In agreement, immature cDC1s in Mycl (-/-) -deficient mice exhibited r

58 interaction resulted in the accumulation of immature cells and reduced granulocytic differentiation.

59 Our results demonstrated that these immature cells have a natural capacity to differentiate

60 n the latter CD34+ cells differentiated into immature cells in vitro, but less efficiently in vivo.

61 For the immature cells, raw numbers and standardizations to brai

62 different environments on proliferative and immature cells.

63 fect of the environment on proliferative and immature cells: (a) the comparison of raw totals of prol

64 omparison of raw totals of proliferative and immature cells; (b) these totals standardized to brain m

65 entiation and inhibited the expansion of the immature CFU-E subset.

66 In the immature cochlea, prior to the onset of hearing, hair ce

67 port that spontaneous Ca(2+) activity in the immature cochlea, which is generated by Ca(V) 1.3 Ca(2+)

68 at habitually napping children may have more immature cognitive networks, as indexed by hippocampal i

69 of a newly defined CD34+CD36+CD71hiCD105med immature colony-forming unit-erythroid (CFU-E) populatio

70 the phenotype of the differentiated cells is immature compared to adult hepatocytes.

71 ong-term applications of farmyard manure and immature compost enhanced the concentrations of Mn, Fe,

72 light-level geolocators on 4- to 9-year-old immature Cory's shearwaters (Calonectris borealis) and o

73 To convert these immature crypts into fully polarized, functional units w

74 of alpha2delta3 enhances neuronal firing in immature cultures, whereas later in development it suppr

75 sensitized lungs with higher efficiency than immature DCs (DCim).

76 In children, most PL cells are immature (DCX+PSA-NCAM+), and during adolescence many tr

77 Furthermore, immature dendritic cells (iDC) responded to mCD40L with

78 gkookjang and B. licheniformis Monocytes and immature dendritic cells (iDCs) responded differentially

79 Human peripheral blood mononuclear cells, or immature dendritic cells derived from human peripheral b

80 melanoma Ag gp100 by human monocyte-derived immature dendritic cells occurred in a vacuolar pathway,

81 FP-treated tumor cells efficiently activated immature dendritic cells, evidenced by enhanced expressi

82 that cibinetide lowered bone-marrow-derived-immature-dendritic cell maturation and subsequently redu

83 l skin was enriched with adipogenic dFBs and immature dermal fat that highly expressed cathelicidin.

84 rall, we found no impact of any pesticide on immature development time and relatively weak effects on

85 to sampling (n = 15) had lower densities of immature doublecortin-positive (DCX(+)) multipolar and b

86 oliferative (Ki-67 immunohistochemistry) and immature (doublecortin immunohistochemistry) cells withi

87 Strikingly, immature eggs do not recruit macrophages, revealing that

88 arget regulation operating within the 15 DAP immature embryo explant provides key molecular hints as

89 9 Ma, from Myanmar) has provided a series of immature enantiornithine skeletal remains preserved in v

90 Mature erythrocytes, immature erythroid cells, and phagocytes accounted for t

91 actor, RbfA, suppresses protein synthesis by immature Escherichia coli 30S subunits.

92 i lack Noggin (NOG) expression, resulting in immature esophagus that contains respiratory glands.

93 , we identify the transcriptional profile of immature excitatory neurons in the human amygdala betwee

94 riched in PUFA is especially challenging for immature, extremely preterm infants who are typically su

95 In cycloheximide chase assays, PIAS4 slowed immature F508del degradation threefold and stabilized ma

96 e takeovers induced a surge in estrogens for immature females of all ages-even females that did not m

97 In the most immature ferrets, cortical neurons developed selectivity

98 ers(21), but the related technology is still immature for practical implementations(22).

99 ules in the endoplasmic reticulum (ER) in an immature form.

100 t development and chlorophyll content in the immature fruit has a major impact on the morphology and

101 tro from progenitors exhibited depolarizing, immature GABA responses, like those of early postnatal R

102 al new insights into how RNA and IP6 promote immature Gag lattice formation.

103 HIV-1 maturation involves conversion of the immature Gag polyprotein lattice, which lines the inner

104 Immature gametocytes develop in the human bone marrow pa

105 isms that are pivotal for the maintenance of immature gametocytes in the bone marrow and provide furt

106 al a novel role for T-bet in suppressing the immature gene signature during murine NK cell developmen

107 onically elevated reactive oxygen species in immature germinal vesicle oocytes, exhibit a significant

108 of the co-release of GABA and glutamate from immature glycinergic MNTB terminals.

109 ell line models and promotes the turnover of immature glycoforms of BCR subunits, reducing total cell

110 The immature glycoforms of SLC26A9 and CFTR co-immunoprecipi

111 Ageing immatures gradually changed from a more exploratory stra

112 oxidation-reduction associated genes in the immature green fruit.

113 culture systems that maintain them as highly immature, ground-state ISCs marked by a single-cell clon

114 community and captured the diversity of the immature gut microbiota over time and in response to int

115 rotein that forms the protein lattice of the immature HIV-1 virion.

116 Immature human immunodeficiency virus (HIV) virions have

117 dataset defines the expression signature of immature human thymocytes and provides a resource for th

118 The few remaining NK cells showed an immature, hyperactivated phenotype, hallmarked by the ba

119 T cells from infant mice were predominantly immature, insensitive to RORgamma-inducing bacterial cue

120 icroenvironment: basophils, eosinophils, and immature, intermediate, and mature neutrophils.

121 tal brain contains late migratory streams of immature interneurons that are directed to cortex and ot

122 s accompanied by enhanced axonaloutgrowth in immature interneurons.

123 n of the ferritins was inhibited, leading to immature iron granules.

124 niles had higher body mass, on average, than immature juveniles, (iv) older males (aged >=4 years old

125 Only starch isolated from shrunken and immature kernels exhibited reduced extractability.

126 germinated, insect-damaged, and shrunken and immature kernels) did not provide significant changes on

127 stem cells, kidney organoids that represent immature kidneys and display some physiologic functions.

128 culating neutrophils appeared phenotypically immature, lacking multilobed nuclei, and neutrophil gran

129 s grown at suboptimal temperature accumulate immature large subunit particles missing several protein

130 d dynamics of CA-SP1 junction helices in the immature lattice.

131 cells contain a highly proliferative pool of immature Lgr5(-)CD44(+) cells, which are prone to transf

132 cific B55alpha deficiency induces pruning of immature-like tumor blood vessels resulting in delayed t

133 xtensive deposits of lipoproteins, including immature lipofuscin, were observed.

134 ds are necessary to initiate zonation in the immature liver has been only partially explored.

135 preleukemic ETP gene expression signature in immature Lmo2 transgenic thymocytes.

136 es, little is known on the time required for immature long-lived migrants to progressively acquire ad

137 ecF(lo)CD11b(+)CD64(-)CD11c(-)CCR2(+)Ly6C(+) immature macrophages (3 d), Ly6G(+) neutrophils (7 d), a

138 ly influx of proinflammatory CCR2(+)Ly6C(hi) immature macrophages.

139 adult mass and condition (wasting), and low immature mass and length (stunting).

140 were run at various applied normal loads on immature, mature and trypsinased (as model of osteoarthr

141 revented increased MC maturation of resident immature MCs.

142 In the absence of ILK, immature melanosomes are not retained in perinuclear reg

143 l immune response toward generating abnormal immature memory B cells (MB), while impairing plasma cel

144 and RNA-seq to compare newborn progenitors, immature MG (P8-P12), and mature MG.

145 of Ascl1 is more effective in reprogramming immature MG, than mature MG, consistent with a more prog

146 These findings indicate that immature MGE interneurons are fundamental for shaping GA

147 RV infection of 6-day-old immature mice causes mucous metaplasia and airway hyperr

148 h microglial progenitors in the yolk sac and immature microglia in early embryos.

149 increased in EpsilonC-betaKO mice suggesting immature microvessels were most sensitive to combined su

150 cterize the formation of lamellar cristae in immature mitochondria during a period of dramatic mitoch

151 ractile force, slower upstroke velocity, and immature mitochondrial function compared with adult card

152 dentify previously undocumented predators of immature monarchs in their summer breeding range in the

153 ive herbivores were found to readily consume immature monarchs, both in a targeted fashion or inciden

154 loid-derived suppressor cells (MDSC) include immature monocytic (M-MDSC) and granulocytic (PMN-MDSC)

155 However, these cardiomyocytes remain immature, more closely resembling the fetal state, with

156 These NKG2DL-negative AML cells show an immature morphology, display molecular and functional st

157 mines habitat-related variation in adult and immature morphometrics among diademed sifakas (Propithec

158 o leverage on the Miami-Dade County, Florida immature mosquito surveillance system based on requested

159 Immature mosquito surveys were conducted throughout Miam

160 Many mammals are born with immature motor systems that develop through a critical p

161 and fibroblast lineages with the features of immature mouse gastric stomach.

162 as those that are cone-evoked or those from immature mouse retinae.

163 a group of heterogeneous cells derived from immature myeloid cells (IMCs).

164 , but not PARP1, increases the population of immature myeloid cells in bone marrow, and impairs the e

165 ls (MDSCs) are a heterogeneous population of immature myeloid cells that proliferate in the setting o

166 cells (MDSCs), a heterogeneous population of immature myeloid cells, expand during chronic viral (HCV

167 Furthermore, the patients' blood contained immature myeloid cells.

168 and monocytes at similar levels to those in immature myeloid cells.

169 enhanced self-renewal, and proliferation of immature myeloid cells.

170 Immature nasoseptal cartilage is more cellular and homog

171 Altricial mammals are born with immature nervous systems comprised of circuits that do n

172 This maturation defect resulted in excess immature neuronal synapses and behavioral abnormalities.

173 These cortical immature neurons (cINs) retain developmentally undiffere

174 egulation of the splicing regulator PTBP1 in immature neurons allows neural-specific splicing of the

175 is associated with an increased presence of immature neurons and gene expression changes in the DG f

176 rocess required for the removal of transient immature neurons and the proper wiring of functional cor

177 effect of the environment on the numbers of immature neurons appears method dependent.

178 Another source of immature neurons in adult brains is cortical layer II.

179 Some immature neurons in the cerebral cortex of mammals might

180 Hyperexcitable immature neurons may contribute to disrupted network int

181 ght bats had significantly higher numbers of immature neurons than the captive-bred bats.

182 itor cells (NPCs) and DCX(+) neuroblasts and immature neurons were detected, but their numbers greatl

183 decreased hippocampal cell proliferation and immature neurons, as well as reduced neural activation.

184 Despite robust effects on immature neurons, growth factors minimally promote axon

185 esistant to infection than undifferentiated, immature neurons.

186 utcome of alphaviral infection in mature and immature neurons.

187 ed dendritic abnormalities in FMRP-deficient immature neurons.

188 anulocyte subset, with characteristics of an immature neutrophil, that had neuroprotective properties

189 Immature neutrophils dominated in both blood and lungs,

190 ROC analysis reveals that the count ratio of immature neutrophils to VD2 (or CD8) T-cells predicts pn

191 In conclusion, we characterize CB-LDG as immature neutrophils with functional deficits and decrea

192 reveals a dramatic increase in the number of immature neutrophils.

193 signatures that correlated with expansion of immature neutrophils.

194 hosphorylated Akt, S6, and STAT1, as well as immature NK cells describe a new phenotype for NK cell C

195 NK cells, EBV predominantly in NK cells, and immature NK cells in the blood.

196 By contrast, precursor and immature NK cells with reduced effector capacity populat

197 ter frequency of cells expressing markers of immature NK cells.

198 d expression of signature genes representing immature NK cells.

199 suppressing the transcriptional signature of immature NK cells.

200 -bet and corrects the abnormal expression of immature NK genes.

201 ells as they first emerge as developmentally immature NKX2-1(GFP+) lung progenitors and subsequently

202 rogen fixation capacity associated with more immature nodules and less elongated bacteroids.

203 g conditions we found that, similar to IHCs, immature OHCs elicited spontaneous Ca(2+) action potenti

204 ccurred in deep layer excitatory neurons and immature oligodendrocyte precursor cells (OPCs), and the

205 Nf1 loss led to a persistence of immature oligodendrocytes that prevented later-generated

206 In vivo, CCNB2 depletion caused ovulation of immature oocytes, premature ovarian failure, and comprom

207 ells have historically been characterized as immature or defective.

208 hurdle for immune checkpoint inhibitors, an immature or impaired immune system and inhibitory tumor

209 ed higher hydraulic permeability than either immature or mature tissues.

210 AMPAR population are permeable to Ca(2+) at immature P4-P5 synapses.

211 Binding of RbgA at the P site of the immature particle stabilizes functionally important rRNA

212 different morphogenetic types assemble their immature particles in distinct regions of the host cell,

213 g Isg15 and Ifit1 expression in blood and an immature pDC phenotype associated with higher IFN produc

214 in SLAMF9(-/-) mice revealed an increase of immature pDCs in the bone marrow and enhanced accumulati

215 nset, accompanied by a prominent increase of immature pDCs in the lymph node, with a reduced costimul

216 Immature pericytes showed stellate shape and high prolif

217 within the clinical management of non-vital immature permanent teeth is of clinical interest.

218 cellular structure and function revert to an immature phenotype during this disease.

219 c findings, microscopic imaging supported an immature phenotype of CB-LDG with decreased S100A12 expr

220 The immature phenotype of human induced pluripotent stem cel

221 electrophysiological measurements, and 3) an immature phenotype which may impact translation to adult

222 beta-cells relegated them to a functionally immature phenotype with characteristic transcriptional a

223 states consistent with a differentiated and immature phenotype.

224 eart failure (HF) reflects a reversion to an immature phenotype.

225 However, PSC-CMs exhibit immature phenotypes in culture, and the lack of maturity

226 biochemical changes occurring in microgreen immature plants (likely in response to the harvest stres

227 Specifically, PARN cleaves the 3'-end of immature, polyadenylated hTR to form the mature, nonpoly

228 bstantial heterogeneity in both effector and immature populations.

229 te types, Types I-III; and basally situated, immature postmitotic type, Type IV cells.

230 ll RNA sequencing (scRNA-seq) to examine the immature postnatal thymocyte population in humans.

231 RET was performed on 24 immature premolars with an autologous blood clot (PC), g

232 molecular specificity of PC synthesis by the immature preterm liver in vivo.

233 olecular patterns leads to the production of immature pro-IL-1beta; subsequently, inflammasome activa

234 rapy, yet most methods generate functionally immature products.

235 different pneumococcal epidemiology or with immature programmes and poor herd immunity.

236 re the most prevalent in CF, with a dominant immature proinflammatory archetype.

237 -cadherin, including the radial migration of immature projection neurons into the cortical plate.

238 found that early life stress leads to a more immature, proliferative DG than would be expected for th

239 nd 15,000,000 protein profiles, finding that immature, proliferative monocyte-lineage cells with redu

240 inferior lobe malformation, characterized by immature Purkinje cells (PCs).

241 1, Igfbp4 and Mef2c are candidate markers of immature PV(+) hippocampal INs (HIN).

242 beta-tricalcium phosphate (beta -TCP) in an immature rabbit model through the time of facial maturit

243 s of 36 blood cell traits (platelets, mature/immature red cells, and myeloid/lymphoid/compound white

244 clinical features were as follows: 36.4% had immature retina without ROP, 22.0% had mild ROP, 5.3% ha

245 In these strains, immature ribosomes escape into the translating pool, whe

246 ping step is required to prevent error-prone immature ribosomes from engaging in protein synthesis.

247 ish a checkpoint that prevents the escape of immature ribosomes into polysomes.

248 point that safeguards against the release of immature ribosomes into the translating pool.

249 represent a sparse cone population or may be immature rods.

250 ose that the cellular membranes required for immature rotavirus particle budding are not an extension

251 ly proliferation but also differentiation of immature Schwann cells (SCs), thereby forming and mainta

252 flower buds appeared 30-40 days on juvenile immature scions grafted onto transgenic rootstock.

253 roposed to activate calcineurin signaling in immature SCs to initiate differentiation and myelination

254 ivum L.), harvested for human consumption as immature seeds, as our model crop and simultaneously ove

255 essors resulting in higher protein levels in immature seeds.

256 us give birth in the bay in early summer and immature sharks occur there until late fall, when decrea

257 Here, transcriptome analysis of immature spike tissues in three lines nearly isogenic fo

258 (2) castes do not structure communities; (3) immature stages (brood) have different bacterial communi

259 spite differences in the bacteria present in immature stages and in male and female adults, there is

260 (2+) -induced action potentials (APs) during immature stages of development, which are driven by Ca(V

261 Immature stages of VLB are transported to new countries

262 During immature stages, adult-born neurons pass through critica

263 causing cortical germ cells to remain in an immature state in the embryo.

264 a major hurdle for their applications is the immature state of these cardiomyocytes.

265 adually regain steady-state maturity from an immature state that is reminiscent of the neonatal stage

266 e detected throughout the cochlea, exhibited immature stereocilia and survived for at least 8 weeks.

267 Immature stress erythroid progenitors (SEPs) are derived

268 ions of off-target staining that occur along immature stress fibers and cell boundaries and choosing

269 mplex 1 (mTORC1) activity and renders young, immature supporting cells incapable of generating hair c

270 Myeloid-derived suppressor cells (MDSCs) are immature suppressive cells found in tumors and immunolog

271 Immature T cells undergo a process of positive selection

272 or GALC in the development and maturation of immature T-box-brain-1 positive brainstem neurons.

273 DL-specific expression of Ddr2 in mature and immature teeth, as well as indicate that DDR2 signaling

274 a compared with those with either NSGCT with immature teratoma or NSGCT without teratoma (5-year CIDD

275 lopment in the thymus, alphabeta TCRs signal immature thymocytes to differentiate into mature T cells

276 l and subsequent oncogenic transformation of immature thymocytes.

277 et-deficient NK cells and found an augmented immature transcriptomic signature.

278 non-treated adult mouse brains and exhibited immature transcriptomic signatures indistinguishable fro

279 CD19(+)CD24(hi)CD38(hi) Immature/transitional B cells elevated in diabetic than

280 Immature/transitional B cells increase remarkably in dia

281 ted inhibition of glutamyl-tRNA reductase by immature tRNA(Glu) We further demonstrate that whereas o

282 tion of the enzyme, since the majority of 5'-immature tRNAs can be aminoacylated unless their 5'-exte

283 f PAP I led to improved aminoacylation of 5'-immature tRNAs.

284 rrests yeast growth in vivo by targeting the immature V(o) subcomplex in the endoplasmic reticulum (E

285 common cause of vision loss in the visually immature versus cataract in the visually mature.

286 Gag-Gag interactions at the early stages of immature viral particle assembly in a p6-independent man

287 onsible for genomic RNA (gRNA) packaging and immature viral particle assembly.

288 ment of their surface proteins (E and prM in immature virus or M in mature virus).

289 hexakisphosphate (IP6) synergize to generate immature virus particles in vitro The results identify a

290 , resulting in the release of non-infectious immature virus particles with uncleaved pr peptide from

291 The immature virus-like particles can be converted into matu

292 t females that is contingent on their early, immature vocalizations.

293 l timepoint at which podocalyxin is ablated (immature vs. mature podocytes) has a profound effect on

294 Finally, during the breeding season immatures were widely dispersed through the North Atlant

295 lls are efficient at capturing microbes when immature, whereupon they can transform into potent antig

296 Furthermore, releasates of immature WPBs from either BLOC-2 or exocyst-depleted end

297 ansport tubules from endosomes, resulting in immature WPBs that lack endosomal input.

298 x phenocopied BLOC-2 depletion, resulting in immature WPBs.

299 rences in volatiles among Stage 2 (partially immature, yellow-green) and subsequent stages were insig

300 Here, we stabilize immature Zika virus via an antibody that binds across th