ライフサイエンスコーパス: immune

1 ciated with a series of in vitro and in vivo immune abnormalities consistent with lymphocyte hyperact

2 Maternal immune activation (MIA) disrupts the central innate immu

3 ntal animal models demonstrate that maternal immune activation (MIA) elevates inflammatory cytokine l

4 work density and/or morphology can result in immune activation or, as recently implicated, in providi

5 retroviral therapy (ART) on HIV suppression, immune activation, and quality of life (QoL).

6 ptionally characterized by markers of type-2 immune activation, inflammation, cellular infiltration,

7 Moreover, plant iron stress triggers immune activation, suggesting that sensing of iron deple

8 ammation, rather than focusing on peripheral immune activation.

9 ated with both central and peripheral innate immune activation.

10 ed to exhibit chronically elevated levels of immune activity, had significantly higher CD4+CD151+ T-c

11 with multiple interactions between genetic, immune and external factors.

12 0%), cell regeneration (n = 115, 39.4%), and immune and inflammatory modulation (n = 79, 27.1%).

13 whole representative data characterizing the immune and inflammatory status in coronavirus disease 20

14 els were characterized at histopathological, immune, and transcriptomic level to identify the unique

15 iligo and are hypothesized to be the site of immune attack in AA.

16 Our results suggest that the microbiome-gut-immune axis can be modified by DEHP and emphasize the va

17 several hundred clinical trials have tested immune-based approaches in childhood cancers, few have b

18 tients with liver injury is indicative of an immune-based mechanism for the observed hepatic enzyme e

19 dings to identifying optimal combinations of immune-based therapies for any given patient.

20 de sex differences in exposure to predators, immune capacity and cost of reproduction.

21 small alpha-helical cytokine that regulates immune cell homeostasis through its recruitment to a hig

22 regulators of gene silencing that establish immune cell identity and function.

23 LRG1 deletion causes impaired immune cell infiltration, reepithelialization, and angio

24 phenotype that is suitable for the study of immune cell interactions.

25 We further show that multiple immune cell populations contain lineage-labeled particle

26 uding markers of atopy, type 2 inflammation, immune cell populations, and cytokines.

27 Tissue-specific CD45(+) immune cell responses occurred at the time of peak disea

28 portunities to enhance the sophistication of immune cell therapies, increasing potency and safety and

29 been used as a research tool for inhibiting immune cell trafficking.

30 lated genes that were similarly expressed in immune cells (hemocytes) and ovarian somatic cells (stre

31 This differs from lymphoid organs, in which immune cells adopt spatially biased positions to promote

32 omarker analysis to characterize the role of immune cells and inhibitory checkpoints, genome-wide fre

33 The mechanisms by which these immune cells converge on target tissues, interact with f

34 Since immune cells display oscillations in numbers and functio

35 Monocytes are innate immune cells essential for host protection against malar

36 ls and tissues of this animal, including the immune cells of the coelomocytes.

37 Immune cells play a central role in early pregnancy esta

38 Excessive generation of oxidants by immune cells results in acute tissue damage.

39 granulomas are organized structures of host immune cells that function to contain the bacteria.

40 e chitin released from hemocytes (phagocytic immune cells) that traffic into the light-organ crypts,

41 Most cell types, including immune cells, can secrete and uptake exosomes.

42 d expression of inflammatory genes in innate immune cells, potentially explaining the link between mu

43 , actively orchestrating the localization of immune cells, to optimize host defence.

44 ons for various epithelial, mesenchymal, and immune cells.

45 gramming the function of innate and adaptive immune cells.

46 ed strong binding to EpiSCs but not to blood immune cells.

47 cell proliferation, renal inflammation, and immune cells.

48 igration and facilitate space exploration by immune cells.

49 autophagy-inflammasome axis in innate murine immune cells.

50 Furthermore, we found that the immune checkpoint 4-1BB had a high selectivity for human

51 Despite the outstanding clinical results of immune checkpoint blockade (ICB) in melanoma and other c

52 ed stage IIIB-IV NSCLC who were treated with immune checkpoint blockade between June 2011 and Decembe

53 entiate immune rejection in combination with immune checkpoint blockade.

54 lasmic chromatin recognition and response to immune checkpoint blockade.

55 in a variety of cancer subtypes, the role of immune checkpoint inhibition in the treatment of prostat

56 Immune checkpoint inhibitor (ICI) therapy is often accom

57 s with bladder cancer is found in the use of immune checkpoint inhibitor therapeutics.

58 , proton pump inhibitor use, and combination immune checkpoint inhibitor therapy were each independen

59 ndently associated with an increased risk of immune checkpoint inhibitor-associated AKI.

60 Although immune checkpoint inhibitors (ICIs) have achieved unprec

61 Immune checkpoint inhibitors (ICIs) have transformed can

62 bates immune events in patients treated with immune checkpoint inhibitors (ICIs).

63 e than cutaneous melanoma to chemotherapy or immune checkpoint inhibitors, encouraging results have b

64 nesis inhibition may augment the activity of immune checkpoint inhibitors.

65 ress the issue of patient stratification for immune checkpoint intervention, we quantitatively imaged

66 d is related to the B7/CD28 family of T-cell immune checkpoint markers.

67 Leukocytoclastic vasculitis (LCV) is an immune-complex mediated vasculitis characterized by neut

68 4) in vitro after activation with zymosan or immune complexes, compared with wild-type (WT) neutrophi

69 (SIgA) is the single most abundant acquired immune component secreted onto mucosal surfaces and, via

70 multiple alterations associated with better immune control: increased infiltration and activation of

71 plant lymphoproliferative disorder; however, immune correlates of EBV DNAemia in the transplant setti

72 lammasomes are important sentinels of innate immune defence that are activated in response to diverse

73 ssential for development, tissue repair, and immune defences.

74 ion is a significant insult to antimicrobial immune defenses.

75 Melanocytes are the target of immune destruction in vitiligo and are hypothesized to b

76 s, including inflammatory, neurological, and immune diseases.

77 itis virus (LCMV) clone 13 (CL13), result in immune dysfunction that predisposes the host to severe i

78 e the transcriptional profile of this airway immune dysfunction, we performed the first single-cell t

79 ocytosis is a rare syndrome characterized by immune dysregulation and hyperinflammation.

80 Thus, data indicate that CVID-associated immune dysregulation is a T(H)1-mediated inflammatory pr

81 th mosaic expression that drives multi-organ immune dysregulation via kinase dependent and independen

82 e background of chronic immunosuppression or immune dysregulation.

83 Immune-dysregulation, polyendocrinopathy, enteropathy, X

84 ts the need to understand the role of innate immune effectors in the complex interactions between inf

85 nockdown had a particularly strong effect on immune effectors that are predominantly activated by the

86 Antibodies are key immune effectors that confer protection against pathogen

87 In this article, we describe the immune environments associated with major B-cell lymphom

88 further associate electrostatic charge with immune escape and viral evolutionary dynamics.

89 -immunity and antigenic mutations that allow immune escape impact influenza epidemic dynamics at the

90 jor B-cell lymphomas with an emphasis on the immune escape pathways orchestrated by these diseases.

91 The model predicts that, without immune escape, tumor neoantigens are either clonal or at

92 rs can only establish after the evolution of immune escape.

93 Thus, cancer methionine consumption is an immune evasion mechanism, and targeting cancer methionin

94 on and that PD-L1 expression is an important immune evasion strategy used by KSHV for its survival an

95 tumor heterogeneity through the selection of immune-evasive clones.

96 nostimulatory Ypt and Ye strains, but not in immune-evasive Yp Analysis of Yp pagP gene sequences ide

97 It is unclear if the flu vaccine exacerbates immune events in patients treated with immune checkpoint

98 nto mucosal surfaces and, via the process of immune exclusion, shapes the architecture of these micro

99 NGFR(hi) tumor fractions are associated with immune exclusion.

100 ssed miRNAs are involved in neuroplasticity, immune function and neurorestoration.

101 d with the condition-dependent expression of immune function and stress response.

102 s and its implication in the pathogenesis of immune function and the development of CF lung disease.M

103 y mass and moult, showed that an increase in immune function was associated with a decrease in body m

104 Exploring the correlations between immune function, body mass and moult, showed that an inc

105 gest that socioeconomic conditions influence immune function, growth and health status.

106 ls maintained body mass despite variation in immune function.

107 specific differences in lactation, diet, and immune function.

108 under eCO(2) results in increased endogenous immune function.

109 tional T cells, much less is known about the immune functions of unconventional T cells and their rol

110 ral pathogens, antibodies mediate additional immune functions that may have both protective and patho

111 Exomic studies have demonstrated that innate immune genes exhibit an even higher degree of variation

112 standard of care treatment with intravenous immune globulin + rituximab with or without plasma excha

113 V-1 infection has been linked to genetic and immune host factors.

114 GLOB), antioxidants (SOD, GPx and GSH), and immune (IgM and lysozyme) parameters in LMB, except ALP

115 Oxidative stress is a central part of innate immune-induced neurodegeneration.

116 he expression of the recently characterized, immune-inducible gene Induced by Infection (IBIN) was di

117 umber of deleted genes while those with high immune infiltrate expressed higher levels of adaptive re

118 Samples with low immune infiltrate had higher number of deleted genes whi

119 l properties, and dysfunctional intratumoral immune infiltration.

120 The early cancer-immune interaction sculpts intratumor heterogeneity thro

121 is to attempt to understand the neural-cell-immune interaction to investigate the underlying mechani

122 the desired target region, in the absence of immune interference by other epitopes.

123 Female humoral immune measures were unaffected, indicating that the pro

124 t Tim-3 expression might represent a natural immune mechanism limiting viral spread.IMPORTANCE HIV in

125 GS-9688 treatment provides insights into the immune mechanisms that mediate this antiviral effect.

126 The elucidation of immune mechanisms underpinning the parasitic infections,

127 the two forms of diabetes mellitus; T1DM is immune mediated and T2DM is mediated by metabolic mechan

128 t to produce toxic byproducts that stimulate immune-mediated damage of hepatocytes and the biliary tr

129 pressive, posing a major hurdle for inducing immune-mediated destruction of cancer cells.

130 netic risk variants associated with multiple immune-mediated diseases are a major determinant of inte

131 is often associated with a variety of other immune-mediated diseases, most commonly inflammatory bow

132 dose intake even at lower doses (<5 mg) in 6 immune-mediated diseases.

133 ay by which type 3 immunity is modulated and immune-mediated pathogenesis controlled.

134 Immune memories are stored in the form of 'spacers' whic

135 y to reinfection, a phenomenon called innate immune memory.

136 ute to altered immunity, the biogeography of immune-microbiome correlations among HEU children have n

137 We also assessed the tumour immune microenvironment in a prospective cohort of patie

138 The glioblastoma immune microenvironment is recognized as highly immunosu

139 herapies induce dynamic changes in the tumor immune microenvironment that vary by subtype and patholo

140 of HSC survival and migration and affect the immune microenvironment, especially macrophages in clear

141 acy of a microbial-based stimulus for innate immune mobilization depends on the correct selection of

142 room for development in macrophage-mediated immune modulation and macrophage-mediated drug delivery,

143 Single-agent immune modulators have thus far proven clinically ineffe

144 oing trials are testing antiviral therapies, immune modulators, and anticoagulants.

145 suppressing phosphatases, and alteration in immune modulators.

146 ression analyses examining associations with immune parameters and key demographics.

147 that are often intensified by host adaptive immune pathways to profoundly advance disease severity.

148 iched for glucocorticoid-regulated genes and immune pathways with some of these genes mediating the e

149 ecreased ubiquitylation and activated innate immune pathways.

150 molecularly classify and characterize tumour-immune phenotypes.

151 scriptomics identified neurotoxic CNS innate immune populations and may enable discovery of selective

152 Using fluid-phase luciferase immune precipitation (LIPS) assays, we characterized IgG

153 Because synovial joints include immune privileged sites, these findings are significant

154 iral humoral responses, define correlates of immune protection, and down-select candidate antivirals.

155 lectrophile-sensitive cysteines in the human immune proteome remains limited.

156 utophagy, have a key function in maintaining immune quiescence of tissue-resident macrophages, result

157 r the CDC intermedilysin, bound to the human immune receptor CD59 in a nanodisc model membrane.

158 MALT1 mediates signaling from many immune receptors in mammals, but was not previously impl

159 hat p53 plays a critical role in controlling immune recognition and responses in normal tissues as we

160 are at risk of the paradoxical TB-associated immune reconstitution inflammatory syndrome (TB-IRIS) wh

161 al molecular axis and a potential target for immune-refractory tumor.

162 ings identify a pathway of estrogen-mediated immune regulation in the intestine, whereby homeostatic

163 y showing the importance of inflammation and immune regulation through the IL18-IL18RAP axis and anti

164 l KRAS-G12C inhibitor AMG 510 can potentiate immune rejection in combination with immune checkpoint b

165 downregulation of matrisome, cell cycle and immune related gene sets in Lcn2(-/-) mice exposed to CC

166 Detailed study of ophthalmic immune-related adverse events (AEs), including determina

167 served 6 of 28 patients (21%) with grade >=3 immune-related adverse events, consisting of asymptomati

168 to immunotherapy and simultaneously identify immune-related adverse events, there are several challen

169 anterior uveitis, the most common ophthalmic immune-related AE, were 8209 per 100 000 for ipilimumab

170 ical pacemaker neurons express a rich set of immune-related genes mediating their interaction with th

171 een distantly related cell types such as the immune-related genes that were similarly expressed in im

172 ibitor (ICI) therapy is often accompanied by immune-related pathology, with an increasing occurrence

173 nregulated pathways in metastases are mainly immune-related.

174 teine modification to alter the functions of immune-relevant proteins; however, our understanding of

175 Vitamin A regulates the adaptive immune response and a modulatory impact on type I allerg

176 Indicators of the neonatal innate immune response are associated with risk of ASD, althoug

177 eiving combination therapy, have an impaired immune response compared to controls.

178 verse transcriptase (RT) inhibitor-sensitive immune response following HIV-1 infection.

179 ytokine production to promote an altered Th2 immune response following RSV infection that leads to mo

180 o other lysosomal storage disorders in which immune response hinders ERT.

181 also allow for a better understanding of the immune response induced after IDV infection.

182 Immune response of mOPV2 was 53.6% (95% confidence inter

183 mechanisms contributing to the dysfunctional immune response of the elderly to the vaccine against in

184 te the molecular underpinnings of the innate immune response of the larvae to the pathogen.

185 viral reservoir along with an HIV-1-specific immune response seems to be key for the spontaneous func

186 protective immunity and amplifies the type 2 immune response that may favor the development of crypto

187 cal first step in understanding the earliest immune response to HIV-1 and suggest that changes in blo

188 uman neutrophils are critical for the innate immune response to S. aureus infection.

189 s suggest that assessing the proinflammatory immune response to trauma exposure immediately after tra

190 earch is needed to understand how to monitor immune response to vaccines in immunosuppressed patients

191 IFN-beta is a key component of the innate immune response to viral infection.

192 y proteins play integral roles in the innate immune response to virus infection.

193 kin cell biology, including activation of an immune response, a switch in cell metabolism and process

194 reatment in high altitude reduced the type 2 immune response, corrected the increased CRTH2 expressio

195 ation that lack rapid testing of the patient immune response, impeding clinicians from providing appr

196 r pharmacologically without compromising the immune response, providing a new approach to treat disea

197 m the thymus to the periphery and during the immune response, we discuss in broad terms developmental

198 d by the same drug (5-azacytidine) elicit an immune response, which may be important for patient's re

199 epitopes and the formation of a hierarchical immune response.

200 tance by developing a more reactive cellular immune response.

201 of Dot1L in T cells resulted in an impaired immune response.

202 affects several pathways of the host innate immune response.

203 AC/JENVAC combination exhibiting the highest immune response.

204 fore may increase the efficacy of the innate immune response.

205 ty of transmission, vectorial competence and immune response.

206 , leukocyte adherence, and activation of the immune response.

207 ary vascular bed is crucial for an effective immune response.

208 closely associated with the induction of an immune response.

209 leads to compromised expression of multiple immune-response-related genes.

210 induced a remarkable increase of functional immune responses against GBS compared to the simple co-a

211 s that cholesterol metabolism impacts innate immune responses against infection.

212 d invariant T (MAIT) cells are important for immune responses against microbial infections.

213 vaccine elicits strong humoral and cellular immune responses against pathogenic Ebola viruses and su

214 monstrate the emergence of pathogen-specific immune responses and a concomitant rise in plasma inflam

215 lamydia must evade both intracellular innate immune responses and adaptive cytotoxic T cell responses

216 tion, ranging from cellular communication to immune responses and the protein-driven mineralization o

217 alterations that blunt productive anti-tumor immune responses by directly or indirectly excluding eff

218 We analyzed immune responses in 76 COVID-19 patients and 69 healthy

219 accine-induced activating versus suppressive immune responses in affording protection from HIV.IMPORT

220 currence rates of UTIs, we examined adaptive immune responses in mouse bladders.

221 We applied PULSE to control immune responses in plant leaves and generated Arabidops

222 pathogenesis, innate viral control, adaptive immune responses or the balance of inflammation and tiss

223 Innate immune responses rely on rapid and precise gene regulati

224 Overexpression of OsWAKL21.2 in rice induces immune responses similar to those activated by LipA trea

225 ts demonstrated that stromal Lama5 regulated immune responses through altering LN structures and T ce

226 Lyz1-deficiency diminished intestinal immune responses to bacterial molecular patterns and res

227 cobacter pylori gastric infection influences immune responses to oral enteric vaccines.

228 e, Takahashi et al. found sex differences in immune responses to SARS-CoV-2 and the predictors of dis

229 ming immunization provides a method to focus immune responses to the desired target region, in the ab

230 ory function, CD40L has been used to enhance immune responses to vaccines, including candidate vaccin

231 Cancer immunotherapies enhance anti-tumor immune responses using checkpoint inhibitors, such as PD

232 s in antiviral defense, influencing adaptive immune responses via interactions with dendritic cells (

233 ge and thromboinflammation, dysregulation of immune responses, and maladaptation of ACE2-related path

234 , Salmonella Typhi, generates cross-reactive immune responses, which provide far greater resistance a

235 1-expressing exosomes can inhibit antitumour immune responses.

236 potentiate ionizing radiation-induced innate immune responses.

237 ete of the host population, and muted innate immune responses.

238 logy of the intestinal epithelium and innate immune responses.

239 ls, by enhancing the quality and survival of immune responses.

240 for infection, gastroenteritis symptoms, and immune responses.

241 ve been described in normal and dysregulated immune responses.

242 of an intracellular niche, and modulation of immune responses.

243 icacy and potency to help Env trimer humoral immune responses.

244 to navigate the B-cell compartment and evade immune responses.

245 roperties, leading to detrimental effects on immune responses.

246 , can result in deleterious pro-inflammatory immune responses.

247 e mosquitoes is regulated by the stress- and immune-responsive c-Jun N-terminal kinase (JNK).

248 neutralizing activity present in SARS-CoV-2 immune sera.

249 g of how rotavirus (RV) subverts host innate immune signaling has greatly increased over the past dec

250 ays that also explain the operation of other immune signaling pathways.

251 disruption of USP7 interactions with innate immune signaling proteins TRAF3 and TRAF6, and that vIRF

252 in AGMs was associated with aberrant innate immune signaling, complement dysregulation, Th2 skewing,

253 form a complex capable of modulating innate immune signalling through the cGAS-STING pathway.

254 equires combinatorial strategies to overcome immune suppression associated with the tumor microenviro

255 ndscape shaped by oncogenic drivers promotes immune suppression from the earliest stages of tumor inc

256 Targeting immune suppression using checkpoint inhibition has resul

257 vascular endothelial growth factor-mediated immune suppression via angiogenesis inhibition may augme

258 h in turn regulates metabolic reprogramming, immune suppression, resistance to apoptosis, angiogenesi

259 ssion of GILZ, thereby maintaining effective immune suppression.

260 We established that the immune-suppressive cytokine interleukin-27 (IL-27) is el

261 s, including cellular stress, DNA damage and immune surveillance.

262 with PD-1 plays an important role in evading immune surveillance; this can be overcome using PD-L1 or

263 we discuss potential mechanisms by which the immune system affects the central nervous system after s

264 te balance between the activity of the donor immune system against malignant and nonmalignant cells o

265 we describe a mechanism by which the innate immune system allows rapid quality check of absorbed flu

266 can still be recognised by the host's innate immune system and persistent BDG antigenaemia, in the ab

267 system is an intricate cascade of the innate immune system and plays a key role in microbial defense,

268 lysis highlighted the potential roles of the immune system and polycomb repressive complex 2 in patho

269 quences of decreased parasite exposure on an immune system are not well understood.

270 stigate the impacts of multiple stressors on immune system development in early life stage fishes.

271 It is clear that the bat immune system differs when compared with other mammals,

272 activation (MIA) disrupts the central innate immune system during a critical neurodevelopmental perio

273 sociation between activation of the maternal immune system during pregnancy and increased risk of neu

274 Poly-N-acetyl-lactosamine is involved in the immune system in many ways.

275 lows unprecedented profiling of the adaptive immune system in submucosal and mucosal isolated lymphoi

276 minent role of the cellular component of the immune system in the development and perpetuation of AF.

277 crosstalk between metabolic tissues and the immune system in the inception and progression of obesit

278 The dance between microbes and the immune system takes place in all biological systems, inc

279 To unravel the contribution of the immune system to CDC pathogenesis, we undertook a prospe

280 the Treg compartment can skew the patient's immune system toward an anti-inflammatory phenotype and

281 ntibody titers and altered expression of the immune system, autophagy, and apoptosis pathway transcri

282 confer adaptive advantages on the mammalian immune system, especially during coinfection and during

283 Because of its impact in the immune system, we investigated the role of osteopontin i

284 f the full differentiative complexity of the immune system.

285 ium and further perpetuated by a predisposed immune system.

286 e strategies tumors employ to circumvent the immune system.

287 ocytes are important players of the adaptive immune system.

288 ation by pathogens, and train the developing immune system.(1)(,)(2) However, humans are unique among

289 lying conditions, and those with compromised immune systems can develop severe disseminated disease.

290 ollowing emergence into secondary hosts with immune systems that diverge from those unique to bats.

291 nsmitting viruses that have evolved with bat immune systems will likely cause enhanced virulence foll

292 es, a diverse family of prokaryotic adaptive immune systems, have emerged as a biotechnological tool

293 ct of oil and hypoxia exposure on developing immune systems.

294 cancer treatment modalities (e.g., gene and immune therapies) are profoundly changing the oncology l

295 D8(+) T cells and restored responsiveness to immune therapy, suggesting an indirect stromally targete

296 5, 2013, and March 7, 2019, 92 patients with immune thrombocytopenia were screened, of whom 74 (80%)

297 and objectively true, and are comparatively immune to authority or peer influence.

298 e to a tone paired with a weak footshock was immune to the IED, but chemogenetic activation of the LC

299 viduals, which may be partly due to baseline immune variations.

300 dation, the CLIV Score based on clinical and immune-virological parameters is potentially useful to s