ライフサイエンスコーパス: immune cell

1 ons for various epithelial, mesenchymal, and immune cells.

2 Aseq experiment involving tumor-infiltrating immune cells.

3 es that modulate the chemotaxis of different immune cells.

4 s soluble form (sDPP4) that directly engages immune cells.

5 ponse in the food allergy model and in human immune cells.

6 suggest an indirect mechanism of action, via immune cells.

7 gramming the function of innate and adaptive immune cells.

8 ytes, microglia, neurons, globoid cells, and immune cells.

9 ed strong binding to EpiSCs but not to blood immune cells.

10 acted phage that nonspecifically bound blood immune cells.

11 reated cell lines representative of skin and immune cells.

12 ssues from collateral damage by antipathogen immune cells.

13 bility and function of both cancer cells and immune cells.

14 mation, and dramatically reduced mononuclear immune cells.

15 requires natural killer (NK) cells and other immune cells.

16 cell proliferation, renal inflammation, and immune cells.

17 through crosstalk with enterocytes and other immune cells.

18 ncing biofilm eradication by antibiotics and immune cells.

19 entation of tumor-specific antigens to other immune cells.

20 igration and facilitate space exploration by immune cells.

21 interplay between human malignant cells and immune cells.

22 autophagy-inflammasome axis in innate murine immune cells.

23 predicted from results obtained with healthy immune cells.

24 pes including cancer cells, fibroblasts, and immune cells.

25 which enhanced inflammatory functions of non-immune cells.

26 gnals from and provide signals to peripheral immune cells.

27 ls, thereby hindering their interaction with immune cells.

28 immunoregulatory glycan-binding receptors on immune cells.

29 ts and was initially devoid of skin-resident immune cells.

30 blasts, smooth muscle, macrophages and other immune cells.

31 on number and functionality of porcine blood immune cells.

32 show lower infiltration of several types of immune cells.

33 cells; and (ii) elevated presence of innate immune cells.

34 ration and a disease-related infiltration of immune cells.

35 iral infection by engaging with receptors on immune cells.

36 ce markers, from tens of thousands of single immune cells.

37 tical for the interactions between tumor and immune cells.

38 , survival, differentiation, and function of immune cells.

39 expression perturbations in peripheral blood immune cells.

40 utoimmune pathology via activation of innate immune cells.

41 uctance regulator (CFTR)-rich ionocytes, and immune cells(1,2).

42 a pneumoniae to determine infectious burden, immune cell abundance, and cytokine production.

43 characterized age-associated alterations in immune cells across multiple mouse organs using single-c

44 simultaneously assess microbiota and single immune cells across the healthy, adult human colon, with

45 g, renoprotective injury response, modifying immune cell actions.

46 or (Ifnlr1) deficiency significantly reduces immune cell activation and associated organ damage in th

47 y in the skin, which resulted in exacerbated immune cell activation and skin pathology, mirroring tha

48 MALT1 plays a central role in immune cell activation by transducing NF-kappaB signalin

49 ient stratification according to patterns of immune cell activation in the kidney or identify disease

50 However, mechanisms of immune cell activation leading to TLOs in COPD remain to

51 individual maps of white matter (WM) innate immune cell activation using (18)F-DPA-714 translocator

52 egrated analyses also uncovered multifaceted immune cell activation within brain malignancies entaili

53 hagocytosis, and diminished pro-inflammatory immune cell activation; data that identifies and catalog

54 s that promote tumor progression and inhibit immune cell activity can enhance antitumor immunity by r

55 This differs from lymphoid organs, in which immune cells adopt spatially biased positions to promote

56 signaling is required for the navigation of immune cells along chemoattractant gradients.

57 the associations between relative counts of immune cell and cancer risks.

58 ment causes large shifts in both circulatory immune cell and microbiota populations, enabling the rel

59 Peripheral blood immune cell and plasma markers were analyzed at day 100

60 usion, resulting in reduced accessibility to immune cells and chemotherapeutic drugs.

61 s the effect of SNS adrenergic signalling in immune cells and conclude with exciting new research dem

62 stinal acidification, influence host mucosal immune cells and enterocytes via butyrate production, or

63 Type 2 immune cells and eosinophils are transiently present in

64 omarker analysis to characterize the role of immune cells and inhibitory checkpoints, genome-wide fre

65 The interaction between immune cells and phosphatidylserine (PS) molecules expos

66 action with allograft-infiltrating recipient immune cells and potential therapeutic approaches.

67 ed that can be used to suppress alloreactive immune cells and prevent lethal GVHD in mice.

68 ew anti-inflammatory role for JAK3 in innate immune cells and show that the underlying signaling path

69 by Toll-like receptor 4-regulated cytokines, immune cells and signalling pathways - contributes to th

70 Characterising the interplay between immune cells and stem cells is crucial to understand how

71 uding the activation and functions of innate immune cells and the emerging innate properties and modu

72 r (NK) cells, by obstructing contact between immune cells and the surrounding target cells.

73 In other words, Env binds to CD4 on key immune cells and transduces signals that can compromise

74 omas showed 43% positivity in both tumor and immune cells and we observed intra and inter tumoral het

75 the genetics of gene expression in neonatal immune cells, and aetiological origins of autoimmune and

76 s modify proteins required for regulation of immune cells, and alterations have been associated with

77 r that normally prevents entry of pathogens, immune cells, and cytokines into cerebrospinal fluid and

78 ated infection risk, opioids activate innate immune cells, and opioids attenuate inflammation in muri

79 xpressing CAR T cells on innate and adaptive immune cells, and provide a rationale for using CD40L-ov

80 restrict viral replication, activate innate immune cells, and regulate adaptive immunity.

81 activity of Janus kinase 3 (JAK3) in innate immune cells, and subsequently phospho-inactivates Nedd4

82 Interestingly, immune cells appear to respond to noise damage by infilt

83 rst evidence that following corneal wounding immune cells are activated to travel along zonule fibers

84 irectional interactions between neuronal and immune cells are altered during disease processes such a

85 mmatory proteins, but changes in circulating immune cells are less well defined.

86 Here, we provide the oxidative stress innate immune cell atlas in neuroinflammatory disease and repor

87 Together, these immune cell atlases have the potential to transform neph

88 o sort millions of live migratory cancer and immune cells based on their spontaneous migration in two

89 a tissue "background" but specifically guide immune cells both in development and pathology.

90 focuses on the roles of the cadre of innate immune cells, both those that are resident in metabolic

91 e that VacA modulates gastric epithelial and immune cells, but the in vivo contributions of VacA as a

92 pothesize that neurotransmitter signaling in immune cells can contribute to behavioral changes associ

93 Although many immune cells can secrete TGF-beta, whether all sources o

94 Most cell types, including immune cells, can secrete and uptake exosomes.

95 naling assays revealed enhancement in innate immune cell chemoattraction, survival, and phagocytosis,

96 We pay close attention to how immune cells chemotax toward pro-inflammatory mediators,

97 s the expression of genes involved in murine immune cell chemotaxis.

98 ction led to chronic reductions in pulmonary immune cell composition and reduced type 2 immune respon

99 stic biopsies replicated the subgroups, with immune cell composition confirmed via immunohistochemist

100 ons to variations in microbial responses and immune cell composition.

101 We found that myeloid and lymphoid resident immune cells concentrate around periportal regions.

102 including endothelial cells, astrocytes and immune cells, constituting a complex and dynamic tumour

103 strongly support experimental evidence that immune cells contribute to acute ischemic brain damage a

104 scape of central nervous system (CNS) innate immune cells contributing to oxidative stress is unknown

105 The mechanisms by which these immune cells converge on target tissues, interact with f

106 in light of emerging roles for astrocytes in immune cell crosstalk.

107 rk Cumulus on the Human Cell Atlas Census of Immune Cells dataset of bone marrow cells and show that

108 The E-protein transcription factors guide immune cell differentiation, with E12 and E47 (hereafter

109 Since immune cells display oscillations in numbers and functio

110 erized by a significant activation of innate immune cells (DPA+) or not.

111 f the metastatic cascade, the trafficking of immune cells during cancer immunotherapy and the distrib

112 nflammatory cytokines are produced by innate immune cells during SARS-CoV-2 infection, we found that

113 The coordinated immune cell dynamics defined in this study provide a fra

114 ut others are more unique features of innate immune cells, enabling them to fulfill their specialized

115 either in cancer or stromal cells, including immune cells, endothelial cells, and fibroblasts.

116 linical disease by having a direct effect on immune cell energy metabolism was tested using extracell

117 Innate immune cells, epithelial cells, and many other cell type

118 ction blistering captured epidermal and most immune cells equally well as biopsies, except for mast c

119 Monocytes are innate immune cells essential for host protection against malar

120 iological systems, including mouse and human immune cells, establishing ChromA as a top performing ge

121 In treatment-naive HGSOC, we found that immune-cell-excluded and inflammatory microenvironments

122 oreactor where they indirectly interact with immune cells flowing within the lumen of the fibers.

123 therapeutic potential of CD147-CAR-modified immune cells for HCC patients.

124 s based on serum transcriptomics and derived immune cell fractions, with significantly different surv

125 rt to pregnancy-induced alteration of innate immune cell frequencies and cytokine expression.

126 HIV attacks the body's immune cells, frequently compromises the integrity of th

127 Donor immune cells from 18 patients were characterized phenoty

128 ve been reported to drain macromolecules and immune cells from CSF into cervical lymph nodes (CLNs).

129 ere able to successfully isolate millions of immune cells from the heavily infected duodenum.

130 dicated exclusion of metabolically repressed immune cells from the tumor-immune boundary.

131 We characterize tumor-infiltrating immune cells from transplant and primary tumors, reveali

132 ion of numerous organs now known to modulate immune cell function and therefore dictate immunological

133 ate that fundamental differences in gingival immune cell function between PD and T2D-potentiated PD m

134 Immune cell function can be modulated by changes in lipi

135 une responses in vivo and paracrine-mediated immune cell function in vitro.

136 Tumors subvert immune cell function to evade immune responses, yet the

137 ction affecting not only adipocytes but also immune cell function.

138 is study, we generated and characterized the immune cell functions of DUSP11-deficient mice.

139 by insights into the control of stromal and immune cell functions.

140 fy pervasive sociodemographic differences in immune-cell gene regulation that emerge by young adultho

141 aques through alterations of resident innate immune cells giving rise to chronic inflammation and pot

142 ons, despite the fact that signaling between immune cells, glia, and neurons is now recognized as ind

143 However, cytotoxicity to immune cells has accompanied the use of covalently react

144 sm of healthy murine and more recently human immune cells has been investigated with an increasing am

145 Microglia, a type of CNS immune cell, have been shown to contribute to ethanol-ac

146 attern recognition receptors found on innate immune cells, have been well studied in the context of c

147 Macrophages are heterogeneous immune cells having a central role in both tissue homeos

148 lated genes that were similarly expressed in immune cells (hemocytes) and ovarian somatic cells (stre

149 hways in malignant, stromal, endothelial and immune cells, hence causing a profound cellular and biol

150 kout mice was accompanied by loss of hepatic immune cells, higher splenic viral burden and reduction

151 nding protein, has emerged as a regulator of immune cell homeostasis by shaping the fate of myeloid a

152 small alpha-helical cytokine that regulates immune cell homeostasis through its recruitment to a hig

153 ing of oxidative stress-producing CNS innate immune cells identified a core oxidative stress gene sig

154 regulators of gene silencing that establish immune cell identity and function.

155 olar macrophages (AM) are the most prominent immune cell in the alveolar space.

156 rophages comprise a majority of the resident immune cells in adipose tissue (AT) and regulate both ti

157 ochemistry, we characterized cerebrovascular immune cells in brain sections from 34 children who died

158 ovides insights into the role of neurons and immune cells in controlling glioma growth, relevant to f

159 n and regulation of both innate and adaptive immune cells in human WAT under conditions of obesity an

160 key inflammatory molecules or the numbers of immune cells in lesional skins.

161 oid hormone receptors and tumor-infiltrating immune cells in metastatic lesions with or without ER mu

162 Microglia are primary innate immune cells in the brain although their direct influenc

163 exposure because of activation of microglial immune cells in the brain.

164 me analysis revealed various IL-10 producing immune cells in the CNS, including most prominently Ly49

165 Despite this asymmetry, resident immune cells in the liver are considered to be broadly d

166 human colon, with paired characterization of immune cells in the mesenteric lymph nodes, to delineate

167 cy to activate inflammatory signaling within immune cells in vitro.

168 n CD83 is known to be expressed by different immune cells including activated CD4(+)Foxp3(+) regulato

169 acteria is a potent activator of circulating immune cells including neutrophils, which foster inflamm

170 Consequently, peripheral immune cells, including pDCs, macrophages, neutrophils,

171 cterial invasion of CRC cells and cocultured immune cells induced a differential cytokine secretion t

172 es were analyzed by immunohistochemistry for immune cell infiltrate composition, by in situ RT-PCR an

173 the lung microenvironment to promote robust immune cell infiltration at the expense of lung function

174 nting cells in particulate form and improved immune cell infiltration in draining lymph nodes.

175 Immune cell infiltration into the lung in the rat OVA mo

176 LRG1 deletion causes impaired immune cell infiltration, reepithelialization, and angio

177 a tumor priming step to improve intratumoral immune cell infiltration.

178 sites, indicating ubiquitous variability in immune cell infiltration.

179 correlation with patient survival and tumor immune cell infiltration.

180 had a gene expression pattern that indicated immune cell infiltration; this tumor type was associated

181 n, enlarged retroperitoneal lymph nodes, and immune cells infiltration, indicating that blocking VEGF

182 how that the SA-IL-4 fusion protein prevents immune-cell infiltration in the spinal cord, decreases i

183 In mice with chronic EAE, SA-IL-4 inhibits immune-cell infiltration into the spinal cord and comple

184 Gastrointestinal microbiota and immune cells interact closely and display regional speci

185 phenotype that is suitable for the study of immune cell interactions.

186 otherapy led to the infiltration of effector immune cells into the lungs, in situ immunization withou

187 ppressor networks, tumour immunogenicity and immune cells involved in antitumour responses may also b

188 herapeutic target in cancer, yet its role in immune cells is not known.

189 ch3 expression in tissue versus infiltrating immune cells is unknown.

190 mmunological tests were performed in primary immune cells isolated from the patients and family membe

191 oteins known to inhibit the activation of an immune cell known as a natural killer (NK) cell.

192 an asthma-like phenotype in mice by inducing immune cell lung infiltration, including eosinophils, in

193 The abnormal immune cells may be the drivers of systemic abnormalitie

194 ystem, recent experimental data suggest that immune cells may play a role in hypertension.

195 oupled receptor (GPCR) GPR84 is expressed on immune cells mediating proinflammatory and immunostimula

196 ere we explore current strategies that shift immune cell metabolism to pro-inflammatory states in the

197 Mutations that impact immune cell migration and result in immune deficiency il

198 suggest that MAGP1-rich microfibrils support immune cell migration post-injury.

199 or requires, C5aR1 activation or influences immune cells more broadly.

200 through partial differential equations, and immune cells (neutrophils and macrophages) are described

201 ne levels correlate and cluster according to immune cell of origin.

202 eview the pleiotropic functions in tumor and immune cells of enhancer of zeste homolog 2 (EZH2), the

203 ar changes in the epidermal, fibroblast, and immune cells of Ovol1-deficient skin that reflect an alt

204 Microglia, the resident immune cells of the central nervous system, engulf surpl

205 Microglia, resident immune cells of the CNS, are thought to defend against i

206 ls and tissues of this animal, including the immune cells of the coelomocytes.

207 ted a 4.5-fold increase in CX3CR1-expressing immune cells (p <= 0.0001), including increased T-cells

208 Dendritic cells (DCs) and other innate immune cells patrol the oral mucosa for infecting microb

209 ayer and the underlying BM for modulation of immune cell phenotype.

210 Immune cells play a central role in early pregnancy esta

211 ional consequence of mirn23a loss modulating immune cell polarization, we assayed syngeneic tumor gro

212 rates, and changes in the composition of the immune cell population in the left ventricle manifested

213 Correlation of immune-cell population frequencies with treatment respon

214 ighlights the interactions between tumor and immune cell populations and reveals how variation in pat

215 We further show that multiple immune cell populations contain lineage-labeled particle

216 ctors can effectively transduce a variety of immune cell populations including CD4(+) T cells, CD8(+)

217 ral other small but biologically interesting immune cell populations invisible to analysis of the ful

218 may be an effective method of targeting the immune cell populations most relevant for antitumoral im

219 so provide insights into the interactions of immune cell populations with neighbouring epithelial and

220 uding markers of atopy, type 2 inflammation, immune cell populations, and cytokines.

221 elay affects commonly measured cytokines and immune cell populations.

222 all survival analysis in patients with PD-L1 immune cell-positive tumours, median overall survival wa

223 d expression of inflammatory genes in innate immune cells, potentially explaining the link between mu

224 lipidomics, metabolomics, autoantibodies and immune cell profiling, complemented with gut microbiota

225 ned to provide robust estimates of tumor and immune cells proportions simultaneously, while accommoda

226 Immune cells react to their environment by flexibly repr

227 lity complexes (MHC) play a critical role in immune cell recognition and can trigger an antitumor imm

228 immune response by regulating blood flow and immune cell recruitment in lymphoid tissues.

229 rectal cancer model, the inhibitor increased immune cell recruitment into tumors.

230 tion of CSF-CCL2 was sufficient to drive ChP immune cell recruitment, activation, and proliferation.

231 responses has thoroughly been studied, other immune cells remain insufficiently explored.

232 protocol provides a framework for proficient immune-cell researchers to test novel T-cell therapies t

233 ly atherosclerosis depends upon responses by immune cells resident in the intimal aortic wall.

234 mor hypoxia, clonal stem cell selection, and immune cell response, all of which have been recently sh

235 type expression and roles as checkpoints in immune cell responses in human diseases such as cancer,

236 Tissue-specific CD45(+) immune cell responses occurred at the time of peak disea

237 Excessive generation of oxidants by immune cells results in acute tissue damage.

238 Single-cell RNA-sequencing of plaque immune cells revealed that unlike Tregs from progressing

239 Hence, immune cell-secreted exosomes may have applications in c

240 Sensory neurons and immune cells share a common microenvironmental niche for

241 an be explained by differences in peripheral immune cell signaling and differentiation soon after the

242 p-value = 3.16E-8) MP-induced alterations of immune cell signaling trajectories, particularly in the

243 he Siglec family, its roles in regulation of immune cell signaling, current efforts to define its rol

244 ate the cycle, metabolism, self-renewal, and immune cell signaling.

245 the immune system and play critical roles in immune cell signaling.

246 emonstrate aggressive phenotypes and attract immune cells simultaneously.

247 actions among various types of cancer cells, immune cells, stroma, angiogenic molecules, and the vasc

248 Every major immune cell subset has been implicated in the unresolved

249 ht differential effects of FTY on peripheral immune cell subsets and suggest that pre-treatment T-cel

250 and delivery of TAM for activation of Cre in immune cell subsets assessed longitudinally and spatiall

251 robust, unsupervised bootstrap clustering of immune cell subsets coupled with random forest analysis

252 formed a flow cytometric characterization of immune cell subsets from 30 patients with COVID-19 and c

253 ndance and activation states of more than 50 immune cell subsets in 35 individuals over 11 time point

254 of small and long RNA sequencing pinpointed immune cell subsets pivotal to these responses, implicat

255 ion reduced the activation of several spleen immune cell subsets, the anti-inflammatory effects of De

256 The presence of these immune cell subtypes is corroborated in other publicly a

257 Peripheral immune cells, such as monocytes and lymphocytes, have al

258 stones with antimicrobial peptides (AMPs) in immune cells suggests that histones may be part of a lar

259 PGA is recognized less effectively by innate immune cells than PGAs from nonpathogenic Bacillus speci

260 Granulomas consist of activated immune cells that cluster together to limit bacterial gr

261 ucosal tissue and are among the first innate immune cells that encounter human immunodeficiency virus

262 Myeloid-derived suppressor cells (MDSCs) are immune cells that exert immunosuppression within the tum

263 granulomas are organized structures of host immune cells that function to contain the bacteria.

264 rounding the CNS host diverse populations of immune cells that influence how CNS-related immune respo

265 The immune cells that populate this typically avascular regi

266 Macrophages, innate immune cells that reside in all organs, defend the host

267 e chitin released from hemocytes (phagocytic immune cells) that traffic into the light-organ crypts,

268 portunities to enhance the sophistication of immune cell therapies, increasing potency and safety and

269 idoglycan (muramyl peptides) activate innate immune cells through nucleotide-binding oligomerization

270 molecular cargo, which can reach vastly more immune cells throughout the lymph node than either the p

271 s, we compared the responses of human innate immune cells to B. anthracis PGA and PGAs from nonpathog

272 onsidered a circulation marker, signaling to immune cells to help them find blood and lymphatic vesse

273 , from transient interactions between motile immune cells to long-lived cell-cell contacts in epithel

274 eneral circulation, using a diverse array of immune cells to protect from pathogens that translocate

275 An ability to promote therapeutic immune cells to recognize cancer cells is important for

276 t producers of IFNalpha and one of the first immune cells to respond to SIV infection.

277 e lens capsule, form a potential conduit for immune cells to the lens.

278 ells appear to play a key role in recruiting immune cells to the liver to actively create an inflamma

279 , actively orchestrating the localization of immune cells, to optimize host defence.

280 mal cells such as fibroblasts, vascular, and immune cells, to spur further discoveries in skin biolog

281 mainly associated to inflammatory response, immune cell trafficking, and infectious disease pathways

282 been used as a research tool for inhibiting immune cell trafficking.

283 sed resistance of the blood-brain barrier to immune cell transmigration.

284 clustering methods were applied to identify immune cell types and subsets significantly associated w

285 e, we review studies on the role of specific immune cell types, cognate innate immune receptors, and

286 r atlas of chromatin accessibility across 81 immune cell types, we asked if a convolutional neural ne

287 gramming MDSCs and TAMs into antitumorigenic immune cells using a drug that would otherwise be too to

288 is known regarding lymph node (LN)-homing of immune cells via afferent lymphatics.

289 Concentration and functionality of Abs and immune cells were assessed.

290 Importantly, mice lacking Ly6e in immune cells were highly susceptible to a murine CoV-mou

291 paradigm that recruitment and activation of immune cells, when instructed appropriately, offer a the

292 pressed in peripheral neurons, epithelia and immune cells, where their activation may cause harmful e

293 ity of AAV-mediated in vivo gene delivery to immune cells which will facilitate both basic and applie

294 distinct cytokine profiles by human myeloid immune cells, which are dependent on FcgammaR activation

295 ing via SUCNR1 guides divergent responses in immune cells, which are tissue and context dependent.

296 d oxidative phosphorylation are rheostats in immune cells whose bioenergetics have functional outputs

297 l therapeutic target expressed on a range of immune cells with functions in different immune response

298 ngs illustrate complex genetic regulation of immune cells with highly selective effects on autoimmune

299 aken to evaluate the molecular signatures of immune cells within the CNS at defined times following i

300 review, we will explore the heterogeneity of immune cells within the visceral white AT and their cont