ライフサイエンスコーパス: immune surveillance

1 t also to prevent malignant transformation ("immune surveillance").

2 s, including cellular stress, DNA damage and immune surveillance.

3 natural killer (NK) cell function and tumor immune surveillance.

4 ns and soluble factors to the lymph node for immune surveillance.

5 itment to the CNS, whereas TH1 cells perform immune surveillance.

6 range of situations of successful and failed immune surveillance.

7 most fundamental question: how they modulate immune surveillance.

8 us, they are crucial participants in mucosal immune surveillance.

9 , while its absence enables escape of innate immune surveillance.

10 roenvironment and allow tumor cells to evade immune surveillance.

11 a highly adaptive yet unconventional form of immune surveillance.

12 , which are important constituents of innate immune surveillance.

13 the level of ZnT8 exposure to extracellular immune surveillance.

14 ve SE to drive CD47 overexpression to escape immune surveillance.

15 leukocytes permitting it's escape from host immune surveillance.

16 ns, which shield the underlying protein from immune surveillance.

17 salivary exosomes from tumor-bearing mice in immune surveillance.

18 t correlate with an effective restoration of immune surveillance.

19 defect in cytotoxic lymphocyte function and immune surveillance.

20 as well as different strategies for evading immune surveillance.

21 mino acid positions most directly exposed to immune surveillance.

22 ramolecular complexes that play key roles in immune surveillance.

23 random walk behavior in T cells to optimize immune surveillance.

24 supporting the notion of metastasis-specific immune surveillance.

25 herpesviruses that helps them to escape host immune surveillance.

26 rlying factors contributing to the abolished immune surveillance.

27 oits a host antiviral factor to evade innate immune surveillance.

28 Dendritic cells have an important role in immune surveillance.

29 proliferation and STK11 with suppression of immune surveillance.

30 ate, and (3) mechanisms of tumor escape from immune surveillance.

31 sure their escape from chemotherapy and host immune surveillance.

32 e Fas signaling pathway to evade host cancer immune surveillance.

33 maintenance of inflammation, and evasion of immune surveillance.

34 cellular machineries shape such hierarchical immune surveillance.

35 tion for the restoration of IFN-gamma-driven immune surveillance.

36 e to targeted therapies and ability to evade immune surveillance.

37 phocytes (IELs) that provide host-protective immune surveillance.

38 verexpression of PD-1 ligands and evasion of immune surveillance.

39 n Alzheimer disease, cancer progression, and immune surveillance.

40 ic checkpoint response to adapt to and evade immune surveillance.

41 (+) T cell responses in order to escape host immune surveillance.

42 trol of virus infections, T cell memory, and immune surveillance.

43 lentiviruses some degree of protection from immune surveillance.

44 ants are innate immune mediators involved in immune surveillance.

45 le and defining the epitopes it presents for immune surveillance.

46 y to prompt or rewire a proficient antitumor immune surveillance.

47 ogenic and may thus be important targets for immune surveillance.

48 otentially enabling infections to evade host immune surveillance.

49 tastasis if they can protect themselves from immune surveillance.

50 n human tumors thereby contributing to their immune surveillance.

51 maintain efficient cell entry while evading immune surveillance.

52 ne dysregulation leading to failure of local immune surveillance.

53 have evolved strategies to evade host innate immune surveillance.

54 g and conceivably act in normal processes of immune surveillance.

55 th irAEs and the risk of compromising cancer immune surveillance.

56 ed to chromosomal instability and evasion of immune surveillance.

57 ellular processes ranging from DNA repair to immune surveillance.

58 as cancer that can be combated by heightened immune surveillance.

59 ributing to the evasion of cancer cells from immune surveillance.

60 target organs in the absence or presence of immune surveillance.

61 ed cell death pathway (PD-1/PD-L1) governing immune surveillance.

62 mphocyte migration is essential for adaptive immune surveillance.

63 a (PDA) forms a major barrier to therapy and immune surveillance.

64 host immunity for viral clearance and cancer immune surveillance.

65 oinflammation-induced fluid accumulation and immune surveillance.

66 ogrammed death-1 checkpoint pathway to evade immune surveillance.

67 risk for de novo tumors, suggesting impaired immune surveillance.

68 ave implications for vaccine development and immune surveillance.

69 ll invasion, migration, bone resorption, and immune surveillance.

70 bility for viral infections and reduce tumor immune-surveillance.

71 s in the tumour microenvironment and ongoing immune surveillance(4-6).

72 transformation of the disease likely impair immune surveillance, activate the nuclear factor-kappaB

73 tatic Stat3-deficient mammary tumors escaped immune surveillance after a long latency or equilibrium

74 se tumor cells, thereby participating in the immune surveillance against cancer.

75 estrate and regulate immune cells to provide immune surveillance against malignancy.

76 Immune surveillance against pathogens and tumours in the

77 of targeted cancer immunotherapy, to enhance immune surveillance against the tumor.

78 dy establishes a tool for further dissecting immune surveillance against, and optimizing adoptive T c

79 oits a host antiviral factor to evade innate immune surveillance and allow enhanced neuroinvasion.

80 ating lymphocytes are key mediators of tumor immune surveillance and are important prognostic indicat

81 Solid cancers are able to escape immune surveillance and are resistant to current treatme

82 During metazoan development, immune surveillance and cancer dissemination, cells migr

83 tal organogenesis and provides insights into immune surveillance and cancer transformation.

84 issues that leads to increased efficiency of immune surveillance and cell interactions.

85 ulatory therapies that improve CD8(+) T cell immune surveillance and clearance of CHIKV infection cou

86 y regulated system with fundamental roles in immune surveillance and clearance.

87 lobulin-like receptors (aKIRs) influence the immune surveillance and clinical outcome of patients wit

88 mmune pruning effect and equilibrium between immune surveillance and clonal expansion.

89 compatibility complex play a central role in immune surveillance and confer risk for autoimmune and i

90 Endogenous IFN-beta has an important role in immune surveillance and control of tumor development.

91 Thus, microglial immune surveillance and cytokine release require THIK-1

92 veral pathologies and is detrimental to host immune surveillance and defence.

93 erated by retrograde menstruation can escape immune surveillance and develop into sustained ectopic l

94 ceptibility to cancer as a result of reduced immune surveillance and enhanced opportunities for virus

95 Iatrogenically impaired immune surveillance and Epstein-Barr virus (EBV) primary

96 However, these cancers may also elude immune surveillance and eradication through the expressi

97 and regeneration, due to their importance in immune surveillance and fluid homeostasis.

98 tial for their survival in host organs under immune surveillance and for metastatic outgrowth under p

99 he lymphatic system is crucial for efficient immune surveillance and for the maintenance of a physiol

100 upport the contribution of iNKT cells to CLL immune surveillance and highlight iNKT cell frequency as

101 network of proteins with important roles in immune surveillance and homeostasis, has been implicated

102 Immune surveillance and homeostatic regulation of skin f

103 ment, particularly to protect pathogens from immune surveillance and host defenses.

104 NK cells provide immune surveillance and host protection against viruses

105 CRISPR RNAs (crRNAs) that are essential for immune surveillance and how it carries out crRNA-mediate

106 effector-like memory CD8(+) T cells in tumor immune surveillance and identify Akt as a key signaling

107 elationship, where microbes undermine cancer immune surveillance and indirectly promote oncogenesis,

108 plex functions for BTN3A molecules in tissue immune surveillance and infection, linking the cell cyto

109 During immune surveillance and inflammation, leukocytes exit th

110 ne ligand 5 (CCL5) and CCL3 are critical for immune surveillance and inflammation.

111 Lymphatic vessels (LVs) are critical for immune surveillance and involved in the pathogenesis of

112 ical for processes such as wound healing and immune surveillance and is exhibited by various cell typ

113 ystem, but since complement is important for immune surveillance and is involved in various homeostat

114 Whereas it generally mediates immune surveillance and is often neuroprotective, excess

115 f cytotoxic activity of lymphocytes disturbs immune surveillance and leads to the development of hemo

116 at extent adipose tissue also contributes to immune surveillance and long-term protective defense rem

117 Such a strategy allows viruses to evade immune surveillance and maximize their replication.

118 arch indicates that some cancer cells escape immune surveillance and metastasize into bone tissue by

119 exosomes, which allow tumor cells to escape immune surveillance and probably even play a role in the

120 A subset of these lesions may escape immune surveillance and progress to invasive cancer; how

121 derstanding how cancer cells can escape this immune surveillance and promote tumor progression repres

122 in the peritoneal cavity, is associated with immune surveillance and protection against peritoneal co

123 NK cells play an important role in immune surveillance and protective immunity, mainly thro

124 ns to facilitate cancer metastasis: suppress immune surveillance and stimulate cancer cell proliferat

125 native class, namely IgE, may offer enhanced immune surveillance and superior effector cell potency a

126 exploit RANK pathway as a mechanism to evade immune surveillance and support the use of RANK pathway

127 that neoantigen heterogeneity may influence immune surveillance and support therapeutic developments

128 ay has emerged as a critical element in oral immune surveillance and susceptibility to inflammatory d

129 y strategy used by malignant tumors to evade immune surveillance and sustain the suppressive tumor mi

130 in stem cell biology, epigenetics, splicing, immune surveillance and the DNA damage response, and hig

131 lls to human skin is essential for long-term immune surveillance and the maintenance of barrier integ

132 the importance of clonal mutations in robust immune surveillance and the need to quantify patient ITH

133 uman islets, a finding with implications for immune surveillance and the regulation of interstitial f

134 associated effector cells in both antitumour immune surveillance and therapy.

135 MV status may greatly hamper the spectrum of immune surveillance and thus favor outgrowth and the dev

136 s that are presented on the cell surface for immune surveillance and tolerance induction by CD4(+) T

137 Yet, how methylation affects immune surveillance and tumor metastasis remains ambiguo

138 seful for the treatment of attenuated cancer immune surveillance and/or bone metastases.

139 gammadeltaT cells provide immune-surveillance and host defense against infection a

140 y biologic processes, such as wound healing, immune surveillance, and development.

141 w oncogenes, and in particular MYC, suppress immune surveillance, and how oncogene-targeted therapies

142 stemness and proliferation, PRC2 may inhibit immune surveillance, and it could be targeted to reactiv

143 her hand, for lymphomas in which measures of immune surveillance are lacking, including follicular ly

144 ses such as antibody trafficking for central immune surveillance, as well as several ongoing intrathe

145 y focus on the immune cell network mediating immune surveillance at a specific oral barrier, the ging

146 -cells to prevent virus spread and establish immune surveillance at barrier tissues.

147 very of thymus immune function, T cells, and immune surveillance bore the seeds for today's targeted

148 cross-reactivity is essential for effective immune surveillance but has also been implicated as a pa

149 entral nervous system (CNS) is essential for immune surveillance but is also the basis for the develo

150 ssue-resident lymphocytes play a key role in immune surveillance, but it remains unclear how these in

151 desired outcome of reinvigorating antitumour immune surveillance, but often at the expense of immune-

152 Viruses can evade immune surveillance, but the underlying mechanisms are i

153 Viral glycoproteins are under constant immune surveillance by a host's adaptive immune response

154 ne activation in DCs, but that HIV-1 escapes immune surveillance by actively suppressing DC maturatio

155 Cancers often evade immune surveillance by adopting peripheral tissue- toler

156 The herpes simplex virus for example evades immune surveillance by blocking peptide transport with a

157 Effective immune surveillance by CD8(+) cytotoxic T cells of intra

158 to the endoplasmic reticulum lumen to enable immune surveillance by CD8(+) T cells.

159 However, cancer cells escape from immune surveillance by downregulating NKG2D ligands.

160 They can alter host signaling and modulate immune surveillance by interacting with the host protein

161 odulate tissue homeostasis and contribute to immune surveillance by interacting with the innate and a

162 -1 (PD-1) immune checkpoint pathway to avoid immune surveillance by modulating T-lymphocyte activity.

163 agments, we find that this cell also escapes immune surveillance by neighboring macrophages, thereby

164 e data suggest that FAK inhibition increases immune surveillance by overcoming the fibrotic and immun

165 results demonstrate that cancers can escape immune surveillance by reactivating a normal development

166 T cells mediate skin immune surveillance by secreting specific cytokines and

167 ated immune system finally elicits antitumor immune surveillance by stimulating T-cell infiltration a

168 This review examines fixed immune surveillance by TRM cells, highlighting features

169 ely use NKR-P1B:Clr-b interactions to escape immune surveillance by wild-type, but not Nkrp1b(-/-), N

170 nt innate immune responses via trigger(s) of immune surveillance, causing cancer cell clearance at th

171 ect chromatin (BCOR, KDM6A, SMARCB1, TRRAP), immune surveillance (CD58, RFXAP), MAPK signaling (MAP2K

172 commensal bacteria in supporting anticancer immune surveillance, define an important role of tumor e

173 murafenib and dabrafenib, and also may evade immune surveillance due to enhanced expression of PD-L1.

174 omotes T lymphocyte trafficking and enhances immune surveillance during infection.

175 plate or dura maintain fluid homeostasis and immune surveillance during steady-state conditions.

176 ortant for tumor cells in evading macrophage immune surveillance during the early stages of tumorigen

177 all metastatic sites participate in systemic immune surveillance equally, and therefore the success i

178 Immune surveillance exploits a fungal apoptosis-like pro

179 As a mechanism to evade endogenous immune surveillance for cell survival, ERbeta interacts

180 ninvasive monitoring tool for posttransplant immune surveillance for pediatric renal transplant recip

181 Cancer cells need to escape immune surveillance for successful tumor growth.

182 helial cells may be an avenue to escape host immune surveillance functions.

183 in the context of viral infections or tumor immune surveillance have been extensively studied; yet h

184 Effective immune surveillance, however, comes at a price.

185 by immune cells has a crucial role in tumor immune surveillance; however, it has also been reported

186 the complement system is involved in cancer immune surveillance; however, its role in cSCC remains u

187 ells are innate lymphoid cells important for immune surveillance, identifying and responding to stres

188 en allergic responses and cancer, applied to immune surveillance, immunomodulation and the functions

189 In addition, innate immune surveillance impacts cell engraftment, yet a stra

190 ce that they affect melanoma progression and immune surveillance in a negative or positive manner tha

191 tivates immunity against tumors that escaped immune surveillance in approximately 30% of cases.

192 eath 1 (PD-1) pathway is critical to inhibit immune surveillance in CLL.

193 2+) fluxes in TILs may contribute to reduced immune surveillance in HNC.

194 B cells participate in immune surveillance in human circulation and tissues, in

195 compartment suppress inflammation and impair immune surveillance in liver cancer.

196 esigning immunotherapy approaches to enhance immune surveillance in MGUS and to break down immune tol

197 pporting the role of alterations in adaptive immune surveillance in progression of these premalignant

198 polymers to proteins is critical for evading immune surveillance in the field of biopharmaceuticals.

199 t the brain-CSF interface with relevance for immune surveillance in the healthy brain and insights in

200 t inhibitors may tip the balance in favor of immune surveillance in these cancers.

201 immunosuppression can inhibit cancer-related immune surveillance in this population.

202 Immune surveillance in tissues is mediated by a long-liv

203 Lymphocytic responses crucial for immune surveillance, including activation, proliferation

204 rs utilize multiple strategies to evade host immune surveillance, including the induction of the chec

205 Our results indicate that colon immune surveillance is distinct from that of the small i

206 ed, the mechanism of how LANA escapes host's immune surveillance is not fully understood.

207 ter understanding of how these tumors escape immune surveillance is required to enhance antitumor imm

208 munity, immunotherapy that is able to induce immune surveillance is still the most promising modality

209 ue proinflammatory DCs, whose role in cancer immune surveillance is unknown.

210 neutrophil arrest while maintaining rolling immune-surveillance is unknown.

211 " signal co-opted by cancers to evade innate immune surveillance, is ubiquitously expressed.

212 on of STAT1-mediated IFN signaling to escape immune surveillance, leading to the development of clini

213 tasis relies on the capacity of the cellular immune surveillance machinery to recognize "nonself", su

214 At the same time, its central position in immune surveillance makes C3 a target for microbial immu

215 of CD16 as a major checkpoint that controls immune surveillance may promote the design of individual

216 ronuclei by cGAS may act as a cell-intrinsic immune surveillance mechanism that detects a range of ne

217 itself inside the host by escaping the host immune surveillance mechanism through restricted protein

218 potentially sensitize infected cells to this immune surveillance mechanism, an outcome that would hav

219 s a model to investigate metastasis-specific immune surveillance mechanisms are also explored.

220 The HIV-1 Nef protein suppresses multiple immune surveillance mechanisms to promote viral pathogen

221 nd pathogenesis, and the ways they evade the immune surveillance mechanisms, will likely lead to the

222 de gene products that enable evasion of host immune surveillance mechanisms.

223 tissue environments in maintaining cellular immune surveillance networks within distinct healthy tis

224 s associated with altering cell identity and immune surveillance networks, which may contribute to tu

225 c T cell immunity and more generally for the immune surveillance of B cells and may be a target for i

226 TING) pathway plays an important role in the immune surveillance of cancer and, accordingly, agonists

227 Given the underlying defective immune surveillance of EBV, patients with high-grade dis

228 ase is hypothesized to result from defective immune surveillance of EBV, with most patients showing e

229 Insufficient immune surveillance of EBV-infected B cells causes life-

230 mmalian models, further characterization and immune surveillance of H15 viruses are warranted.IMPORTA

231 plicated in the initiation, progression, and immune surveillance of human cancer.

232 vating NKG2D receptor involved in cancer and immune surveillance of infection.

233 Altered immune surveillance of MMR-deficient tumors, and other h

234 This suggests potential differences in immune surveillance of primary tumor and metastasis.

235 ries leading to an improved understanding of immune surveillance of the central nervous system (CNS)

236 ole of CD16(+) monocytes in the steady-state immune surveillance of the CNS and suggest that CD16(+)

237 immunity, which is primarily concerned with immune surveillance of the CNS, and-according to recent

238 Microglia provide immune surveillance of the CNS.

239 tatic conditions, gammadelta T cells provide immune surveillance of the epidermis, intestinal, and or

240 the CNS and are widely recognized for their immune surveillance of the healthy CNS.

241 yse and compare their contribution to innate immune surveillance of the lung in the steady state with

242 ain the tissue's waste products, and ensures immune surveillance of the tissues, allowing immune cell

243 hold great promise for treating disease, but immune surveillance of these macromolecules can drive an

244 oxic microenvironment negatively affects the immune surveillance of tumors by NK cells through the mo

245 lts reveal the capacity of VEGF-C to promote immune surveillance of tumours, and suggest a new therap

246 pressing microglia, providing evidence of an immune surveillance pathway in the central nervous syste

247 Th2 immunity and allergic immune surveillance play critical roles in host response

248 However, as greater insight into the immune surveillance process is gained, we have reevaluat

249 r-intrinsic processes that inhibit essential immune surveillance processes, such as phagocytosis and

250 hese tumor-intrinsic events provoke a robust immune surveillance program elicited by T cells, which i

251 rtant roles in tumor progression by altering immune surveillance, promoting vascular dysfunction, and

252 Our studies support the concept of immune surveillance providing molecular insights into th

253 ression and under the selective pressures of immune surveillance, remain unknown.

254 hough the mechanism of myeloid cell-mediated immune surveillance remains unclear.

255 Lymphocyte homeostasis and immune surveillance require that T and B cells continuou

256 d signatures of tumor cell proliferation and immune surveillance responses.

257 hibitor-treated tumors, we found evidence of immune surveillance resulting in negative selective pres

258 human oral environment, suggesting a unique immune surveillance role within the periodontium.

259 Macrophages have other immune surveillance roles including the acquisition of c

260 Understanding how immune surveillance shapes the cancer genome could help

261 To escape immune surveillance, some viruses have evolved strategie

262 provide mechanistic insights into the tumor immune surveillance state in response to radiotherapy an

263 of optimized combinatorial reactivation and immune surveillance strategies designed to purge the lat

264 The cost of this immune surveillance strategy is the potential for inappr

265 roenvironment that regulate metabolic needs, immune surveillance, survival, invasion as well as cance

266 d cells without being detected by the host's immune surveillance system.

267 ls (TRM) constitute a major component of the immune-surveillance system in nonlymphoid organs.

268 The complement cascade is an ancient immune-surveillance system that not only provides protec

269 ains how Shigella evades a broad spectrum of immune surveillance systems by cooperative inhibition of

270 ssential cue for the localization of CCR8(+) immune surveillance T cells within healthy human skin.

271 During immune surveillance, T cells survey the surface of antig

272 uld improve patient survival by restoring NK immune surveillance that can eradicate glioma cells.

273 gests that immune-rich TNBCs may be under an immune surveillance that continuously eliminates many im

274 ovel associations between gene mutations and immune surveillance that could impact the response to im

275 and SCS in what we speculate is a program of immune surveillance that helps achieve LN barrier immuni

276 een implicated broadly in the suppression of immune surveillance that prevents colonization at the me

277 he central nervous system undergoes constant immune surveillance that takes place within the meningea

278 and how C. burnetii evades the intracellular immune surveillance that triggers an inflammatory respon

279 ation, as in wound healing, development, and immune surveillance, the integrin expression profile und

280 Although MDSCs are known to suppress immune surveillance, their roles in directly stimulating

281 To survive inside host lesions and to evade immune surveillance, this pathogen has developed many st

282 with PD-1 plays an important role in evading immune surveillance; this can be overcome using PD-L1 or

283 Our bodies are equipped with powerful immune surveillance to clear cancerous cells as they eme

284 to developing tumors and can participate in immune surveillance to eliminate neoplastic cells.

285 How the virus evades immune surveillance to establish effective infection is

286 treatment that leverages both senescence and immune surveillance to therapeutic ends.

287 ggest how liver fibrosis might reduce CD8 TE immune surveillance toward infected or transformed hepat

288 host-pathogen context for their functions in immune surveillance, vesicles enable multiple modes of c

289 Falpha, also facilitate NKG2D ligand-induced immune surveillance via both facilitating T-cell chemota

290 er cell-activating receptor ligands to evade immune surveillance via the transcriptional co-factor PA

291 Significant inhibition of genes regulating immune surveillance was observed in Igfbp7(-/-) murine l

292 To address how BCR-ABL(+) leukemia escapes immune surveillance, we developed a peptide: MHC class I

293 Thus, ILC3s can mediate immune surveillance, which constantly maintains a proper

294 erestimated despite its major role in tumour immune surveillance, which has been established in a var

295 city and dedifferentiation programs to avoid immune surveillance, which in turn drives metastatic dis

296 oming and survival, with an ability to evade immune surveillance, which is critical for cell-based th

297 long-term immunological memory and systemic immune surveillance, which protected the mice against tu

298 nsition, tumor cell dormancy and escape from immune surveillance, with emerging functions in establis

299 The AHR is known to regulate immune surveillance within the intestine through retenti

300 ma9delta2T cells play a major role in cancer immune surveillance, yet the clinical translation of the