ライフサイエンスコーパス: immunity

1 +/IgG+ (indeterminate), or IgM-/IgG+ (waning immunity).

2 alk that is required for optimal anti-tumour immunity.

3 rn-triggered immunity and effector-triggered immunity.

4 ge populations contribute to T cell-mediated immunity.

5 e and effector phases to generate protective immunity.

6 abundance, type I IFN signaling and effector immunity.

7 For example, vaccines rarely provide perfect immunity.

8 s tissue homeostasis and provides protective immunity.

9 low expression of STAT5 and impaired T cell immunity.

10 cancer immunotherapy through activating gut immunity.

11 regulator of T cell metabolism and antitumor immunity.

12 entral target of NO bioactivity during plant immunity.

13 proposed to play a second messenger role in immunity.

14 us plasma cells is a major quest of adaptive immunity.

15 e sufficient for parasite-induced protective immunity.

16 STL-1 influences type-17 pulmonary bacterial immunity.

17 ly defined minimal length of protective ZIKV immunity.

18 ng some, but not all, mediators of antiviral immunity.

19 l cycle arrest, genotoxic stress, and innate immunity.

20 istancing and hasten the acquisition of herd immunity.

21 alent OPV2 recipients having higher baseline immunity.

22 n the tumor, resulting in enhanced antitumor immunity.

23 nucleic acids are crucial signals for innate immunity.

24 may contribute to human disease and altered immunity.

25 llosis correlates with impairments in innate immunity.

26 es, CVac-chloroquine did not produce sterile immunity.

27 y is associated with recovery of CD4+ T cell immunity.

28 channels is central to effective anti-viral immunity.

29 ng and their potential for engineering plant immunity.

30 dinucleotide signalling in mammalian innate immunity.

31 rtance for complement recognition and innate immunity.

32 ical information and are critical for T-cell immunity.

33 ion and if seroreactivity is associated with immunity.

34 t could benefit from treatments that augment immunity.

35 nd younger populations may result in trained immunity.

36 are crucial for generating long-term humoral immunity.

37 d cross-reactivity dependent on pre-existing immunity.

38 s is essential for dMMR-triggered anti-tumor immunity.

39 rotein region is not essential to protective immunity.

40 nosuppressive functions hindering anti-tumor immunity.

41 mechanisms by which inflammation may inhibit immunity.

42 allows timely induction of innate antiviral immunity.

43 ble factor (HIF) in the regulation of innate immunity.

44 L protein as a driver of anti-ZIKV intrinsic immunity.

45 munity and to identify those who have gained immunity.

46 Cs) play a critical role in shaping adaptive immunity.

47 or P2X5 as a critical mediator of protective immunity.

48 ghts into the regulation of human anti-tumor immunity.

49 eveal a critical role for pDCs in antifungal immunity.

50 on that can be targeted to improve antiviral immunity.

51 e innate immune cells, and regulate adaptive immunity.

52 functional coordination in vertebrate innate immunity.

53 at1 is a nonredundant regulator of mammalian immunity.

54 ne platforms and struggle to induce balanced immunity.

55 lides), provide a potent source of exogenous immunity.

56 hogen-associated molecular pattern-triggered immunity.

57 the reactivation efficiently boosts anti-VZV immunity.

58 but also affect the gut microbiota and host immunity.

59 f tumor inception to subvert adaptive T cell immunity.

60 lly recognized as key mediators of antiviral immunity.

61 d new insights into the regulation of innate immunity.

62 e their intracellular survival or evade host immunity.

63 ferons, a key component in vertebrate innate immunity.

64 riven apoptosis and the complement system of immunity.

65 ompanying inborn errors of type I interferon immunity.

66 their ability to orchestrate T cell-mediated immunity.

67 n of FcgammaRIIB in regulating CD8(+) T cell immunity.

68 disease can result from monogenic errors of immunity.

69 had crippling effects on adaptive antitumor immunity.

70 es is dependent on the component of baseline immunity.

71 PLDgamma3, is specifically involved in plant immunity.

72 s and provide anti-microbial and anti-tumour immunity.

73 TME by targeting metabolic pathways to favor immunity.

74 ivated polio vaccine (IPV), to ensure type 2 immunity.

75 trating complex biological processes such as immunity.

76 Trained immunity, a functional state of myeloid cells, has been

77 This review addresses meningeal immunity, a less-studied aspect of neuroimmune interacti

78 sist long-term, contributing to long-lasting immunity after infection or vaccination.

79 or two WRKYs as positive regulators of plant immunity against bacterial and potentially non-bacterial

80 cells that activated CD8(+) T cell-mediated immunity against cancer.

81 Their role in plant immunity against hemibiotrophic fungal infection remains

82 manner without suppressing local or systemic immunity against infectious agents or cancer.

83 r cross-presentation and CD8 T cell-mediated immunity against intracellular pathogens and tumors.

84 em in bacteria and archaea provides adaptive immunity against mobile genetic elements.

85 spectively, which confers protective trained immunity against Mtb.

86 +) CD4(+) T cells associated with protective immunity against ocular herpes infection and disease.IMP

87 e cornea that was associated with protective immunity against ocular herpes.

88 4(pos)CD8(pos) thymocytes modulates cellular immunity against PRRSV and other pathogens.

89 ection with SARS-CoV-2 results in protective immunity against reexposure.

90 ost Covid-19 patients, long-lived protective immunity against SARS-CoV-2 after primary infection migh

91 didate vectored vaccine to elicit protective immunity against SARS-CoV-2.

92 These APECs redirect pre-existing CMV immunity against tumor cells in vitro and in mouse cance

93 in prokaryotes, where they provide adaptive immunity against virus infection and plasmid transformat

94 R-Cas systems provide bacteria with adaptive immunity against viruses.

95 sted long before the development of adaptive immunity, although they have been given different names.

96 nisms responsible for this antibody-mediated immunity (AMI) to Y. pestis remain poorly understood.

97 Waning immunity among measles cases, associated with secondary

98 rapy for cancer is capable of inducing tumor immunity, an antitumor effect that results from enhanced

99 s of milk including the provision of passive immunity and a microbiome and, in humans, the psychosoci

100 However, pre-existing vector immunity and a pro-inflammatory vaccine adjuvant may inf

101 vaccination elicited both a stronger trained immunity and adaptive immune phenotype.

102 measured to assess the induction of trained immunity and adaptive responses, respectively.

103 gnaling subverts the induction of protective immunity and amplifies the type 2 immune response that m

104 ance of plasmids, they also act in bacterial immunity and antibiotic tolerance.

105 lear how such ecologic competition via cross-immunity and antigenic mutations that allow immune escap

106 es about the mechanistic connections between immunity and body mass under different diet compositions

107 e ability of S. aureus to resist nutritional immunity and cause infection.

108 tical cellular interactions regulating tumor immunity and defines mechanisms underlying myeloid-targe

109 is a key regulator of both pattern-triggered immunity and effector-triggered immunity.

110 ead 2'3'-cGAMP signaling in insect antiviral immunity and explain how a family of cGAS-STING evasion

111 So far, viral targets of cellular immunity and factors determining successful mounting of

112 l insights into HC1 as a regulator of innate immunity and further elucidate the role of HC.HA complex

113 tion of reactive oxygen intermediates during immunity and has been recently implicated as a critical

114 basic biology of adjuvant-elicited cellular immunity and have clear implications for the screening a

115 D226 surface expression, enhanced anti-tumor immunity and improved efficacy of immune checkpoint bloc

116 ve peptides, naturally encountered in innate immunity and infection, could have important medical and

117 t need for information on virus replication, immunity and infectivity in specific sites of the body.

118 us combinations of autophagy genes, regulate immunity and inflammation(5-12).

119 in Cox's Bazar, Bangladesh, to assess polio immunity and inform vaccination strategies.

120 , supported by its potential to boost innate immunity and initial epidemiological analyses which obse

121 Type 2 cytokine responses promote parasitic immunity and initiate tissue repair; however, they can a

122 f parameters underlying effective anti-tumor immunity and is available to the research community.

123 iotic intestinal bacteria modulate antiviral immunity and levels of circulating alphaviruses within h

124 ell effector molecule that regulates humoral immunity and limits systemic autoimmunity.

125 uding escape behavior, associative learning, immunity and longevity.

126 ound the genetic foundations governing tumor immunity and molecular determinants associated with clin

127 Immunity and nutrition are two essential modulators of i

128 ss its implications for the dynamics of herd immunity and on projections of the global impact of SARS

129 ptomic analysis revealed induction of innate immunity and phagocytotic pathways in presymptomatic SOD

130 ression of CsACD2 in citrus suppresses plant immunity and promotes Las multiplication, phenocopying o

131 , the DeltahemB SCV failed to elicit trained immunity and protection from a secondary infectious chal

132 oint blockade effectively restores antitumor immunity and results in a significant survival benefit.S

133 imultaneously defective in pattern-triggered immunity and the MIN7 vesicle-trafficking pathway, or a

134 play an important role in organ homeostasis, immunity and the pathogenesis of various inflammation-dr

135 y associated with differences in both innate immunity and the stool microbiome in a biogeographical p

136 erent cells and their cross-talk shape tumor immunity and therapy efficacy in patients with cancer.

137 ities to study the systems biology of innate immunity and to determine how sustained ISG upregulation

138 ave significant and broader implications for immunity and vaccine development against pathogenic Salm

139 his niche, and many are important in mucosal immunity and vaccine development.

140 ith neuropathology in patients with impaired immunity and/or inflammatory diseases.

141 tional features that modulate SI microbiome, immunity, and barrier function and identify dietary, epi

142 of tissue integrity, recognition by cellular immunity, and cell death are all buffered by blocking st

143 We used estimates of seasonality, immunity, and cross-immunity for human coronavirus OC43

144 he acquisition of STING into metazoan innate immunity, and determine the structure of a full-length T

145 for cellular homeostasis, tumor suppression, immunity, and gametogenesis.

146 to some bacterial infections, in anticancer immunity, and in anticancer therapies involving DNA dama

147 hed light on the origins of regulated innate immunity, and may have relevance to our understanding of

148 ome sequencing (WES), analyses of VZV T-cell immunity, and pathogen recognition receptor function in

149 chanisms that regulate pathogen elimination, immunity, and pathology is essential to better character

150 n-specific Th2 responses toward Th1 and Th17 immunity, and protects from allergen challenge after onl

151 T cells are important mediators of adaptive immunity, and receptor-ligand interactions that regulate

152 are heterogeneous, and their roles in tumor immunity are controversial.

153 processes associated with heightened Type 2 immunity are not merely a tissue "background" but specif

154 Clinical features of dysregulated immunity are recorded with a standardised questionnaire

155 NA repair, cell death, the IGF1 pathway, and immunity are under increased evolutionary constraint in

156 IL)-1beta is a key mediator of antimicrobial immunity as well as autoimmune inflammation.

157 nd pathology but does not confer sterilizing immunity, as evidenced by detection of viral RNA and ind

158 Heritability of passive immunity associated traits (range 0.02-0.22) and the dis

159 nding cells, and reprogram the expression of immunity-associated genes by binding on effector binding

160 ncoding guanosine triphosphatase (GTPase) of immunity-associated proteins (GIMAPs).

161 7.9% (11/29; 95% CI, 20.7%-57.7%) maintained immunity at 12 months.

162 3.3% (13/30; 95% CI, 25.5%-62.6%) maintained immunity at 12 months.

163 oting inflammatory ILC2 responses and type 2 immunity at mucosal barriers.

164 nity without compromising effector-triggered immunity, because the ability of this variant to re-asso

165 In this issue of Immunity, Bonavita et al.

166 ng mucosal and systemic humoral and cellular immunity but did not exhibit delayed acquisition compare

167 fake antigens," as they are unable to induce immunity, but may react with and cross-link preformed dr

168 factor RNP-6/PUF60 whose activity suppresses immunity, but promotes longevity, suggesting a tradeoff

169 tudies suggest that BHLHE40 regulates type 2 immunity, but this has not been demonstrated in vivo.

170 ion models allow researchers to examine host immunity by investigating the timing, inoculum, route of

171 ytotoxic T cells play a key role in adaptive immunity by killing infected or cancerous cells.

172 ted that viruses can subvert type III CRISPR immunity by means of a potent anti-CRISPR ring nuclease

173 he cell death or survival decisions in plant immunity by modulating multiple stress-responsive proces

174 highly plastic cells with critical roles in immunity, cancer, and tissue homeostasis, but how these

175 r mitochondrial processes, as well as innate immunity, chronic inflammation, cell cycle, circadian rh

176 inflammatory response, dysregulated adaptive immunity, coagulation abnormalities, hemorrhage, and mul

177 hat rely on a single toxin to cause disease, immunity correlates with toxin neutralization.

178 ic polymorphisms associated with poor fungal immunity could lead to a personalized assessment for the

179 ors with diverse functions in metabolism and immunity-critically contribute to thymic integrity and f

180 riggered AHR activation suppresses intrinsic immunity driven by the promyelocytic leukemia (PML) prot

181 ecently linked to the production of acquired immunity effectors such as antibodies.

182 nner in basal resistance, effector-triggered immunity (ETI) and regulation of defense gene expression

183 In plants, pathogen effector-triggered immunity (ETI) often leads to programmed cell death, whi

184 s injury, the recruitment of cells of innate immunity exerts a mechanistic role in disease progressio

185 hat prior to influencing activation, Th1/Th2 immunity first controls the size of the permissive host

186 stimates of seasonality, immunity, and cross-immunity for human coronavirus OC43 (HCoV-OC43) and HCoV

187 Effectors alter host metabolism and immunity for the benefit of pathogens.

188 e results suggest that the loss of exogenous immunity from foliage under eCO(2) results in increased

189 ce payments, jury awards, the presence of an immunity from malpractice liability, the Centers for Med

190 ich influenza recurrence depends upon waning immunity from prior-infection is undefined.

191 In the presence of CRISPR-Cas immunity, full-length AcrIIA1 uses its two-domain archit

192 a cytokine with critical innate and adaptive immunity functions.

193 se 2, related to thyroid function and innate immunity) genes and, in the Amazon, the gene encoding fo

194 eity, and the role they play in coordinating immunity has grown rapidly.

195 ase, and their involvement in STING-mediated immunity have been extensively studied.

196 terial mechanisms for overcoming nutritional immunity have been identified, the intersection between

197 pulmonary disorder in which inflammation and immunity have emerged as critical early pathogenic eleme

198 g the prevalence and longevity of protective immunity have left vulnerable communities fearful that t

199 studies of plant iron home-ostasis and plant immunity have traditionally been carried out in isolatio

200 As a marker of activation of innate immunity, high PCT levels affect clinical diagnosis, can

201 infected (HUU) children, with altered innate immunity hypothesized to be a cause.

202 All models were parameterised to have a herd-immunity immunization threshold of around 90% coverage,

203 ation, which may aid viral evasion of innate immunity.IMPORTANCE Human leukocyte antigens (HLAs) are

204 ion due to loss of protective antiviral host immunity.IMPORTANCE The current trend in CNS disease bio

205 mory (Trm) CD8(+) T cells mediate protective immunity in barrier tissues, but the cues promoting Trm

206 unity, indicating a critical role for innate immunity in endometrial control of C. trachomatis infect

207 robiome, their effect on innate and adaptive immunity in health and disease with a special focus on o

208 lasma effector GRA15 affects cell-autonomous immunity in human and murine cells.

209 the potential therapeutic value of targeting immunity in human stroke.

210 Antiviral immunity in insects is mediated by the RNA interference

211 for this cytokine as a central regulator of immunity in lymphatic organs.

212 ession was associated with higher anti-tumor immunity in most solid malignancies.

213 rotective role for mucosal antibody-mediated immunity in naturally exposed children.

214 volution of this field of research on innate immunity in obesity and metabolic perturbation, as well

215 production were found in Th1, Th2, and Th17 immunity in response to both unspecific and pathogen-spe

216 f eosinophils severely compromises antitumor immunity in syngeneic and genetic models of colorectal c

217 Here, an overview of mucosal immunity in the context of cancer and mucosal cancer cli

218 critical role for inflammation and adaptive immunity in the onset of cancer and in shaping its respo

219 ls are not likely the cause for the enhanced immunity in the pldgamma1 line.

220 e programming and is a critical regulator of immunity in the tumour microenvironment.

221 l function in inflammatory disease and tumor immunity in vivo.

222 ression in transgenic rice causes ambivalent immunity: increased susceptibility to M. oryzae and Xant

223 mice with or without deficiency in adaptive immunity, indicating a critical role for innate immunity

224 better understanding of how donor intrinsic immunity influences allograft acceptance and survival wi

225 is an essential component of humoral innate immunity, involved in resistance to selected pathogens a

226 This cardinal feature of adaptive immunity is achieved by the assembly of a functional AgR

227 rucial for treating diseases in which type 2 immunity is an important component.

228 Increasing evidence indicates that type 2 immunity is associated with disease progression by promo

229 nsporter activity in the regulation of plant immunity is corroborated by experiments using the specif

230 SDE15 suppression of plant immunity is dependent on CsACD2, and overexpression of C

231 iously unappreciated pathway by which type 3 immunity is modulated and immune-mediated pathogenesis c

232 a potential strategy to suppress host innate immunity is not well understood.

233 tanding the mechanisms underlying anti-tumor immunity is pivotal for improving immune-based cancer th

234 ation is a rare event which significance for immunity is poorly understood.

235 ents may have played in the evolution of bat immunity is poorly understood.

236 ing the origin and fate of T cells in tumour immunity is the lack of quantitative information on the

237 he degree of protection conferred by natural immunity is unknown for many enteropathogens, but it is

238 pends on bacteria-specific or tumor-specific immunity is unknown.

239 tant or redundant for effective induction of immunity is, however, still unclear.

240 In this issue of Immunity, Jackson-Jones et al.

241 In this issue of Immunity, Kumagai et.

242 In this issue of Immunity, Li et al.

243 reby improving cardiovascular regulation and immunity long after SCI.SIGNIFICANCE STATEMENT Spinal co

244 In response to this immunity, many phages have anti-CRISPR (Acr) proteins th

245 ors such as Slc11a1 that promote nutritional immunity may therefore reflect what the pathogen 'feels'

246 inistration time on the induction of trained immunity.METHODSEighteen volunteers were vaccinated with

247 essee, United States, were surveyed for host immunity, microbiome and pathogen dynamics.

248 patterns underlying these cell type-specific immunity networks, we developed a tool to analyze paired

249 In this issue of Immunity, Oherle et al.

250 No vaccine to boost mucosal immunity, or as a therapeutic, has yet been developed to

251 cine-rich-repeat (NLR) networks, to regulate immunity pathways against host-adapted biotrophic pathog

252 genesis between males and females, including immunity postinfection, have been well documented, as ha

253 diverse biological phenomena, such as aging, immunity, proteostasis and programmed cell death.

254 atory signaling downstream of various innate immunity receptors.

255 Transmission reducing immunity, reducing the burden of infection in mosquitoes

256 ed by periodic importations to areas of high immunity reflected by immediate termination of imported

257 sed by mutations in the NLR gene SNC1 or the immunity regulator PAD4.

258 All immunity-related genes were upregulated in the bumblebee

259 pathway of macrophages with upregulation of immunity relevant cytokine and co-stimulatory markers.

260 loping improved vaccines that elicit broader immunity remains a public health priority.

261 between exogenous and endogenous sources of immunity remains unknown.

262 r regulators of salicylic acid (SA)-mediated immunity, repressing the biosynthesis of SA in healthy p

263 the classic exclusion conferred by the phage immunity repressor, the phenotype observed in B3-like ly

264 The objective of a shield immunity strategy is to help to sustain the interactions

265 eceptors important for axon guidance, innate immunity, synapse development, and synaptic plasticity.

266 m used by Plasmodium vivax to escape humoral immunity targeting PvDBP, the key ligand involved in ret

267 t BALB/c mice in the presence of preexisting immunity than rA4G RSV.

268 HIV infection and may contribute to altered immunity, the biogeography of immune-microbiome correlat

269 mice with an ATXN2 ASO also modified innate immunity, the complement system and lysosome/phagosome p

270 xert antitumor activity and prime protective immunity, the pathways driving this phenotype remain unc

271 Generating durable humoral immunity through vaccination depends upon effective inte

272 nal cord injury (SCI) significantly disrupts immunity, thus increasing susceptibility to infection, a

273 ntify a novel role for FSTL-1 in innate lung immunity to bacterial infection, suggesting that FSTL-1

274 mechanisms by which CHIKV subverts antiviral immunity to establish and maintain a persistent infectio

275 at potential in spintronics because of their immunity to external magnetic disturbance, the absence o

276 d the role of Semaphorin 3E (Sema3E) in host immunity to Leishmania major infection in mice.

277 ample, the placenta, enhancing fetal humoral immunity to levels similar to their mothers'.

278 categorized by ACIP criteria for presumptive immunity to MMRV.

279 Humoral immunity to pathogens and other environmental challenges

280 Many pathogens subvert intestinal immunity to persist within the gastrointestinal tract (G

281 In line with the compromised immunity to Pst DC3000, ccc1 mutants show reduced expres

282 h understanding of the mechanisms of humoral immunity to SARS-CoV-2(4).

283 field studies to advance an understanding of immunity to SARS-CoV-2, leading to protection and durati

284 mming at this time point is not required for immunity to stem rust.

285 evelopment, the mechanisms of cell-intrinsic immunity to T. gondii in the brain and muscle, and the l

286 activation of alloreactive and autoreactive immunity toward the engrafted islets.

287 coronin 1 promotes allograft tolerance while immunity towards a range of pathogenic microbes is maint

288 tabolism/integrity in betaCA3-mediated basal immunity under both CO(2) conditions.

289 lator(6), is triggered to repress CRISPR-Cas immunity upon surface association.

290 ies) or more broadly reactivate antileukemia immunity (vaccines, checkpoint blockade).

291 systems provide anti-viral and anti-plasmid immunity via a dual mechanism of RNA and DNA destruction

292 Adaptive immunity vitally depends on major histocompatibility com

293 Reconstitution of CMV-specific T cell immunity was evident and CMV-specific ACT may trigger a

294 on of gene networks associated with adaptive immunity was linked to the suppression of networks for t

295 of vaccination time on induction of trained immunity was studied in an independent cohort of 302 ind

296 Although presumed to induce T cell-mediated immunity, whether tumor elimination depends on bacteria-

297 reduce NLRC4 activation enhances protective immunity, which could have important implications for va

298 Distinguishing preexisting and de novo immunity will be critical for our understanding of susce

299 ogens, leading to acquired pathogen-specific immunity with a robust memory T-cell repertoire.

300 sitive to SA could enhance SA-mediated basal immunity without compromising effector-triggered immunit