ライフサイエンスコーパス: immunopathology

1 wing RSV infection that leads to more severe immunopathology.

2 al for control of parasitemia and associated immunopathology.

3 ion of inflammatory monocytes that triggered immunopathology.

4 d protects the cerebellum from infection and immunopathology.

5 in joint-associated tissues, which prevented immunopathology.

6 mune activation may also contribute to fetal immunopathology.

7 D-mannose may have clinical applications for immunopathology.

8 ential for confronting infection but causing immunopathology.

9 P. berghei to A. gambiae without triggering immunopathology.

10 roaches to overcome glucocorticoid-resistant immunopathology.

11 type I IFN signaling and diminution of lung immunopathology.

12 fluenza A virus with this IL-2C reduces lung immunopathology.

13 orate organ damage in the setting of sterile immunopathology.

14 onses yet avoid inappropriate activation and immunopathology.

15 ote efficient viral clearance while limiting immunopathology.

16 ontributing to this process while preventing immunopathology.

17 robiota, activation of immune responses, and immunopathology.

18 ng NETs with DNase protects mice from type-2 immunopathology.

19 for viral clearance, they also contribute to immunopathology.

20 ing a novel strategy of host protection from immunopathology.

21 L-27, regulate ILC2 cells to restrict type 2 immunopathology.

22 T cell memory while simultaneously reducing immunopathology.

23 sponsive to antigenic stimulation to prevent immunopathology.

24 sociated with a failure to resolve pulmonary immunopathology.

25 liver, where they can regulate immunity and immunopathology.

26 with host immunity, but the other can cause immunopathology.

27 ost defence and tissue repair but can induce immunopathology.

28 clinical implications for local immunity and immunopathology.

29 tic cells to reduce M. tuberculosis-elicited immunopathology.

30 st a potential role in both host defence and immunopathology.

31 further implicating SHP2 in lupus-associated immunopathology.

32 also associated with reductions in pulmonary immunopathology.

33 ate into Foxp3(+) Treg cells that suppressed immunopathology.

34 rs of modern immunology and a pathfinder for immunopathology.

35 ponses that may result in host defense or in immunopathology.

36 , but early IFN-I administration ameliorates immunopathology.

37 (ILC2 cells) and infection-associated type 2 immunopathology.

38 critical drivers of autoimmune diseases and immunopathology.

39 have been implicated in both protection and immunopathology.

40 sing increased susceptibility to RSV-induced immunopathology.

41 response resulted in CD4(+)-T-cell-dependent immunopathology.

42 cts against development of lung eosinophilic immunopathology.

43 y, these cells mediated little virus-induced immunopathology.

44 may be useful for inhibiting immune complex immunopathology.

45 can limit excessive inflammation and prevent immunopathology.

46 t play distinct roles in immunity as well as immunopathology.

47 gens, or arthritogenic peptides, might drive immunopathology.

48 efense is elicited through processes such as immunopathology.

49 olled, hyperactive CD8(+) T cells to prevent immunopathology.

50 tribute to the promotion of viral spread and immunopathology.

51 CM) to study the roles of IRGM1 and IRGM3 in immunopathology.

52 hanisms might protect against immune complex immunopathology.

53 d its expansion could control virus-mediated immunopathology.

54 ay be needed to fully suppress Th17-mediated immunopathology.

55 cerbate rather than prevent coronavirus lung immunopathology.

56 environment are not required for this severe immunopathology.

57 Ngamma-producing former TH17 cells and fatal immunopathology.

58 finity maturation contributes to binding and immunopathology.

59 ts contributes to limiting T. gondii-induced immunopathology.

60 s are important for our understanding of HIV immunopathology.

61 t M. tuberculosis by preventing PMN-mediated immunopathology.

62 ntiviral immune responses can trigger lethal immunopathology.

63 gainst inappropriate CTL differentiation and immunopathology.

64 touch within hours to protect the host from immunopathology.

65 sues and a putative role of these T cells in immunopathology.

66 responses to CNS viral infections that limit immunopathology.

67 differentiation in hypoxia, which can limit immunopathology.

68 al infection, thereby contributing to airway immunopathology.

69 lungs and noses of mice without evidence of immunopathology.

70 ation in CL, thereby contributing to disease immunopathology.

71 fected lung tissue but is absent in areas of immunopathology.

72 to amplify the infection or trigger harmful immunopathology.

73 uction or function of cytokines can underpin immunopathology.

74 s both for T cell-mediated viral control and immunopathology.

75 entions that may broadly prevent CSS-induced immunopathology.

76 not enhance clearance or significantly alter immunopathology.

77 nse is not only protective but also mediates immunopathology.

78 y a critical role in disease progression and immunopathology.

79 ntrol their reactivation to prevent damaging immunopathology.

80 eostasis, prevents autoimmunity, and reduces immunopathology.

81 us, could protect patients from tuberculosis immunopathology.

82 fective response to infection while avoiding immunopathology.

83 nd subsequent uptake by APCs without causing immunopathology.

84 se yet promotes transmission by causing lung immunopathology.

85 cytotoxic response, which may contribute to immunopathology.

86 s operational as well as thereafter to avoid immunopathology.

87 cells can, when left unchecked, drive severe immunopathology.

88 rinsic to CD8 T cells and protection against immunopathology.

89 utes to clear persistent infections or limit immunopathology.

90 ion, and its inhibition leads to exaggerated immunopathology.

91 lting in chronic inflammatory and autoimmune immunopathologies.

92 attractive therapeutic target in a range of immunopathologies.

93 sponses including factors that contribute to immunopathologies.

94 lso associated with the development of human immunopathologies.

95 ne interventions (including vaccination) and immunopathologies.

96 RISK6 scores correlated with lung immunopathology activity, measured by positron emission

97 First, the recognition that host immunopathology affects lesional TB drug distribution me

98 d indeed increase the risk of developing HLH immunopathology after lymphocytic choriomeningitis virus

99 imuli but whose overactivation can result in immunopathologies and sometimes even death.

100 damental role in balancing viral control and immunopathology and also functions to regulate T cell re

101 irus (SARS-CoV) vaccines identified cellular immunopathology and antibody-dependent enhancement as po

102 vation are necessary for induction of type 2 immunopathology and aspirin sensitivity.

103 itation of signaling is essential to prevent immunopathology and autoimmune disease.

104 n age-matched males, but also suffer greater immunopathology and autoimmune disease.

105 inth infection, both by controlling damaging immunopathology and by inhibiting protective immunity.

106 In murine schistosomiasis, immunopathology and cytokine production in response to p

107 liorates disease severity and alleviates CNS immunopathology and demyelination, associated with decre

108 wever, excess inflammation may contribute to immunopathology and disease progression (e.g. inflammati

109 se cytokines can contribute to host-mediated immunopathology and disease progression.

110 lasmablasts, and macrophages affect systemic immunopathology and dysregulation, which likely leads to

111 l lymph nodes and analyzed long-term cardiac immunopathology and functional decline in wild type and

112 therapeutic targets to prevent postischemic immunopathology and heart failure.

113 s in vitro and significantly reducing tissue immunopathology and HLH disease manifestations in vivo.

114 However, its role in cancer immunopathology and immunotherapy is poorly understood.

115 le Treg activity results in autoimmunity and immunopathology and impairs the quality of pathogen-spec

116 acted phase of the syndrome to relieve early immunopathology and late immunosuppression, respectively

117 In allergic lung disease models, immunopathology and local Th2 and ILC2 accumulation is r

118 ted mice exhibited protection against ocular immunopathology and maintained corneal mechanosensory fu

119 sts hypercytokinemia is the driving cause of immunopathology and morbidity/mortality in hyperinflamma

120 AV) is frequently characterized by extensive immunopathology and proinflammatory signaling that can p

121 y a fundamental role in ocular herpes T cell immunopathology and provide important immune checkpoint

122 generating a testable 'metapathway' model of immunopathology and providing new insights for treatment

123 nses is a potential strategy for controlling immunopathology and related diseases.

124 , genetic depletion of IRAK-M did not affect immunopathology and renal dysfunction during early posti

125 of the factors that influence HIV-1-induced immunopathology and subsequent CD4(+) T-cell decline is

126 g the balance between immunosurveillance and immunopathology and suggest that specific SphK1 inhibito

127 iosis, because it mediates ehrlichia-induced immunopathology and supports bacterial replication, perh

128 ncreased viral load; however, the heightened immunopathology and susceptibility to subsequent asthma

129 lls, which restricts C. difficile-associated immunopathology and the accumulation of IFN-gamma-expres

130 Very recent experimental data about the immunopathology and the determinants of autoantibody for

131 enic Th cells, but that this subset mediates immunopathology and tissue destruction.

132 ws that greater immunity could predispose to immunopathology and transmission at the lung apex.

133 is hypothesized to arise because of greater immunopathology and/or autoimmunity.

134 H17-like phenotype in Aspergillus-associated immunopathology, and identifies key players, i.e. TLR2 a

135 equency of cavitation (32% vs 7%; P = .029), immunopathology, and mortality.

136 volves early Toll-like receptor (TLR)-driven immunopathology, and resolution of inflammation is neede

137 influencing multiple facets of HIV-1-related immunopathology, and that a greater focus on this parame

138 into the regulation of hepatic injury, liver immunopathology, and transplant tolerance.

139 ow this ultimately leads to vascular damage, immunopathology, and worsening clinical outcomes.

140 demonstrate that reductions in pulmonary TB immunopathology are dependent on hematopoietic VitD resp

141 the mechanisms underlying the development of immunopathology are incompletely understood.Objectives:

142 accumulate in the lung and contribute to TB immunopathology are not fully delineated.

143 Both host defense and immunopathology are shaped by the ordered recruitment of

144 Highlighting immunopathology as a death cause, infected animals are r

145 ferent in vivo models of CysLT(2)R-dependent immunopathology, as well as ex vivo activation of mouse

146 RSV-associated illness is in part caused by immunopathology associated with a robust type 2 response

147 Antibiotic-induced immunopathology associated with bacterial cell wall lysi

148 sponse, preventing early viral clearance and immunopathology associated with CD8 T cell activity in t

149 -10 overproduction substantially reduced the immunopathology associated with GVHD.

150 estrained IL-17 signaling is associated with immunopathology, autoimmune disease, and cancer progress

151 R229Q) microbiota further contributed to the immunopathology because its transplant into WT recipient

152 Lung TCD8 impairment may prevent immunopathology but also contributes to recurrent lung i

153 he JAK1/2 not only prevents the onset of HLH immunopathology but also is effective against existing H

154 ctive role by limiting infection-induced gut immunopathology but can also lead to persistent pathogen

155 ased effector function and cause more severe immunopathology, but ultimately undergo a massive declin

156 cA during MRSA skin infection contributes to immunopathology by altering peptidoglycan structure.

157 kotrienes (cysLTs) facilitate mucosal type 2 immunopathology by incompletely understood mechanisms.

158 e of viral infection but also contributes to immunopathology by inducing neuroinflammation.IMPORTANCE

159 factor beta (TGF-beta), Breg cells suppress immunopathology by prohibiting the expansion of pathogen

160 P1A1 enzymatic activity ameliorated the skin immunopathology by restoring beneficial AHR signaling.

161 ect evidence of modulation of gluten-induced immunopathology by the microbiota.

162 tonomously suppress their responses to limit immunopathology by upregulating inhibitory receptors suc

163 Protection against eosinophilic immunopathology by vaccines containing delta inulin adju

164 suggest that control of infection-associated immunopathology can be based on a unified defense operat

165 Corresponding to the exaggerated immunopathology caused by IL-22 suppression, Salmonella

166 to control pulmonary fungal replication and immunopathology caused by induced type 2 Th2 cell respon

167 of Gd-lip with respect to hepatotoxicity and immunopathology caused by inflammation.

168 d mononuclear cells, and extensive pulmonary immunopathology compared with wild-type (WT)-->WT chimer

169 y and mitigate the potential vaccine-induced immunopathology, CpG 1018, a Th1-biasing synthetic toll-

170 terns nor the impact of Il10 on LCMV-induced immunopathology differed conspicuously between these two

171 The mechanisms protecting from immunopathology during acute bacterial infections are in

172 vival modulates host inflammation and tissue immunopathology during acute respiratory viral infection

173 r that plays a crucial role in limiting host immunopathology during bacterial infections by controlli

174 her either influenced bacterial clearance or immunopathology during Chlamydia muridarum genital tract

175 nes are also important for preventing lethal immunopathology during chronic infection.

176 aintenance of the Th17 cell lineage, but not immunopathology during experimental autoimmune encephalo

177 nterplay between host antiviral immunity and immunopathology during hepatitis E virus (HEV) infection

178 tablish that TLR2 controls neutrophil-driven immunopathology during infection with M. tuberculosis HN

179 IFN-gamma) drives antiparasite responses and immunopathology during infection with Plasmodium species

180 ially protects against severe egg-associated immunopathology during infection, while allowing worm-an

181 flammation at mucosal surfaces, and regulate immunopathology during infectious responses.

182 ding which of these cell types contribute to immunopathology during inflammatory diseases.

183 sine receptor A(2A) were more susceptible to immunopathology during intraperitoneal infection with T.

184 a mutant could restore the capacity to cause immunopathology during murine vaginitis to this avirulen

185 onses that are associated with protection or immunopathology during oral or vaginal infections.

186 ge-responsive lung fibroblasts drives lethal immunopathology during severe influenza virus infection.

187 l that increases inflammasome activation and immunopathology during skin infection.

188 t in vivo and contributes to protection from immunopathology during viral clearance.

189 ever, the in vivo inflammatory responses and immunopathology elicited by acute challenge with the sta

190 with MCMV (LCMV+MCMV), they had more severe immunopathology, enhanced viral burden in multiple organ

191 e history of LCMV infection intensifies MCMV immunopathology, enhances MCMV burden in multiple organs

192 lpha or solTNF-alpha in regulating pulmonary immunopathology following influenza infection are unclea

193 The severity of immunopathology from non-infectious inflammation is main

194 past 20 years, insights into cardiovascular immunopathology have provided a plethora of new potentia

195 of NK-cell cytotoxicity in limiting HLH-like immunopathology, highlighting the important role of NK c

196 to an effective antiviral response but also immunopathology if RLR activities are uncontrolled.

197 promotes Th1 and Th17 responses and gastric immunopathology, IL-18 is required for Treg differentiat

198 GM-CSF rather than IL-17 induces spontaneous immunopathology in a mouse model of CNS inflammation.

199 for programming of CD8(+) T cells to mediate immunopathology in a self-tissue.

200 3 elicits antifungal resistance with limited immunopathology in A. fumigatus infection.

201 While T cells-mediated immunopathology in CHIKV infections has been reported, t

202 Protection against gluten-induced immunopathology in clean SPF mice was reversed after sup

203 a expansion, further enhanced gluten-induced immunopathology in conventional SPF mice.

204 ed interleukin-17A (IL-17A) can mediate late immunopathology in graft-versus-host disease (GVHD), how

205 rant state was found to protect mice against immunopathology in Gram-negative and Gram-positive infec

206 arginase-expressing gMDSCs to regulate liver immunopathology in HBV infection.

207 gested an important role for T-cell-mediated immunopathology in LF pathogenesis, but the mechanisms b

208 ively and negatively modulate gluten-induced immunopathology in mice.

209 by drinking-water supplementation suppressed immunopathology in mouse models of autoimmune diabetes a

210 litis (EAE) is a valuable model for studying immunopathology in multiple sclerosis (MS) and for explo

211 ay in the perpetuation of IL-12/Th1-mediated immunopathology in PBC.

212 e potent regulators of antiviral T cells and immunopathology in persistent viral infection.

213 This increase results in exacerbating immunopathology in select organs, ranging from transient

214 nt of spontaneous autoantibody responses and immunopathology in systemic lupus erythematosus patients

215 CD4- cytotoxic iNKT cells may contribute to immunopathology in TB-IRIS.

216 However, the severity of immunopathology in the context of alloimmune diseases su

217 s-host interactions take place, resulting in immunopathology in the form of inflammation, immune acti

218 f inflammatory cytokines which contribute to immunopathology in the mouse brain.

219 also increased neuroinflammation and caused immunopathology in the mouse brain.

220 or cells (MDSCs) to suppress T cell-mediated immunopathology in this setting.

221 multiple sclerosis and causes characteristic immunopathology in which central nervous system (CNS) de

222 nfection in others, and cause mortality from immunopathology in yet others.

223 arasite down-regulation of host immunity and immunopathology, in allergy and other immune disorders,

224 pread of and eventually clears the pathogen, immunopathology is a major contributor to tissue damage

225 Therefore, understanding their immunopathology is crucial.

226 le of TCD8 impairment in viral clearance and immunopathology is unclear.

227 but persistent MAVS signalling leads to host immunopathology; it remains unknown how these signalling

228 truction is an initial event in tuberculosis immunopathology, leading to caseous necrosis and comprom

229 Severe immunopathology may drive the deleterious manifestations

230 was not observed, and this absence of severe immunopathology may have contributed to the recovery and

231 e reveal that phenomena often interpreted as immunopathology may in fact be beneficial to the host.

232 egation is important for innate immunity and immunopathology mediated by eosinophils and clarify how

233 nization but failed to induce robust vaginal immunopathology (neutrophil recruitment, interleukin-1be

234 uction of IL-1beta, which contributes to the immunopathology observed in cutaneous leishmaniasis pati

235 ull life cycle and recapitulates some of the immunopathology observed in patients with chronic infect

236 echanisms are ultimately responsible for the immunopathology observed in patients with systemic lupus

237 Extensive immunopathology occurs in human immunodeficiency virus (

238 disease outcome.IMPORTANCE Understanding the immunopathology of acute HIV-1 infection will help to de

239 scribes a new murine model to understand the immunopathology of AIR and its association with T cell r

240 be used to further our understanding of the immunopathology of bovine tuberculosis and to produce mo

241 Bacterial burden and pulmonary immunopathology of chimeric mice lacking TLR2 in the hem

242 isease (COVID-19).Objectives: To compare the immunopathology of COVID-19 acute respiratory distress s

243 h in protection and in the cytokine-mediated immunopathology of dengue, how the balance is maintained

244 The diverse immunopathology of granulomas and cavities generates a p

245 (IM), as a fatal illness that magnifies the immunopathology of IM in boys with the X-linked lymphopr

246 her, these findings provide insight into the immunopathology of neuropsychiatric complications that a

247 ng, will provide important insights into the immunopathology of PC dyscrasias and MM immunotherapy.

248 s study, we evaluated the viral dynamics and immunopathology of SHIV.CH505 in rhesus macaques.

249 cellular and molecular understanding of the immunopathology of silicosis, are highlighted.

250 activation molecule directly related to the immunopathology of the disease and is a potential clinic

251 against infection and may contribute to the immunopathology of the disease.

252 nd cytokine production, resulting in altered immunopathology of the lungs compared to A2AP-deficient

253 ion are discussed in relation to the complex immunopathology of this condition.

254 elopment of a memory response nor exacerbate immunopathology of vaccinated mice over at least a 4-mon

255 studies to address mechanisms underlying the immunopathology of VZV-associated posterior uveitis.

256 th significantly increased lung eosinophilic immunopathology on day 6 postchallenge, this was not see

257 , nor its progeny, is solely responsible for immunopathology or autoimmunity.

258 n peripheral immune cells that might lead to immunopathology or protective immunity in severe COVID-1

259 that they have an 'outside-in' effect on CNS immunopathology) or following their compartmentalization

260 with other settings of immunoprotection and immunopathology; others, including basophil and plasmacy

261 erleukin-4 (IL-4) responses, suggesting that immunopathology predominantly reflects an inadequate vac

262 was discontinued, parasitism rebounded, and immunopathology recurred.

263 L-1beta during RSV infection ameliorates RSV immunopathology, reduces the consequences of allergen-in

264 /organ-threatening systemic inflammation and immunopathology regardless of the context in which it oc

265 o evidence for altered VVC susceptibility or immunopathology, regardless of estrogen administration.

266 al cell that is responsible for driving full immunopathology remains unidentified.

267 ysiological contributions of SAPs to vaginal immunopathology require hypha formation, other hypha-ass

268 Immunopathology required antigen-specific CD4 T cells an

269 ted CD73(-/-) mice against T. gondii-induced immunopathology, suggesting that the absence of CD73-gen

270 lammation, epithelial regeneration, and lung immunopathology that are dysregulated during influenza v

271 ld play an important role in the detrimental immunopathology that is seen in aspergillosis.

272 c NET overflow is a novel viral mechanism of immunopathology that may be responsible for characterist

273 However, a comprehensive analysis of the immunopathology that results from infection with this vi

274 nd macrophages are targets of HIV-1-mediated immunopathology, the impact of high viremia on activatio

275 in limiting CNS autoimmunity and preventing immunopathology, these data define a detrimental role of

276 oss-priming DC in post-myocardial infarction immunopathology through presentation of self-antigen fro

277 in and inflammation of the joints, a similar immunopathology to rheumatoid arthritis.

278 lation of LDHA in T cells protects mice from immunopathology triggered by excessive IFN-gamma express

279 ndicating that SHIV.CH505 elicits intestinal immunopathology typical of SIV/HIV infection.

280 Additionally, gastric immunopathology was accelerated in Helicobacter pylori-i

281 dose challenge with LCMV clone 13, increased immunopathology was associated with a reduced number of

282 ponses, during challenge with PICV increased immunopathology was directly associated with these cross

283 e alleviating effect of Il10 on LCMV-induced immunopathology was found to be operative in delayed-typ

284 Like Prf1-/- mice, immunopathology was largely rescued by CD8 depletion or

285 bility to vaginal colonization and resulting immunopathology, we asked whether estrogen use in the st

286 cell response and its role in protection and immunopathology, we characterized the plasmablast respon

287 the effects of excess IL-18 on virus-induced immunopathology, we infected Il18-transgenic (Il18tg) mi

288 As NK cells potentially contribute to immunopathology, we investigated whether RSV affects the

289 whether SHP2 alters autoimmunity and related immunopathology, we treated MRL/lpr mice with an SHP2 in

290 Clinical features and airway immunopathology were assessed.

291 sue repair; however, they can also result in immunopathologies when not properly restricted.

292 they have decreased protection and enhanced immunopathology when reexposed to one of the two viruses

293 ant-induced MAS model, excess IL-18 promoted immunopathology, whereas perforin deficiency had no effe

294 emarkably proficient at preventing chlamydia immunopathology, whereas the multifunctional Tc1 clone d

295 treatment of MRSA skin infection exacerbates immunopathology, which is IL-1 dependent.

296 unctions may serve to reduce T cell-mediated immunopathology while still allowing for effective antiv

297 ses characterized by HBV replication without immunopathology, whilst L-arginine decreased.

298 orchestrates inflammatory responses and lung immunopathology with diminished survival.

299 function to altered functionality to prevent immunopathology, with potential differences between canc

300 ign of novel therapeutic options to minimize immunopathology without impairing beneficial host defens