ライフサイエンスコーパス: impermeant

1 faster than DTT), whereas the parent TCEP is impermeant.

2 positively charged and is therefore membrane-impermeant.

3 lammonium (TEA+) and choline were relatively impermeant.

4 , which is frequently assumed to be membrane impermeant.

5 cells with drugs that are normally membrane impermeant.

6 rejected as drugs because they are membrane-impermeant.

7 ied by higher capillary blood flow with cell impermeants.

8 apeutic agents are blood-brain barrier (BBB) impermeants.

9 with either SKF96365 (30-100 microM) or cell-impermeant 1,2-bis(o-amino-5-bromophenoxy)ethane-N,N,N',

10 ane-permeant biotin maleimide and a membrane-impermeant 2-((5(6)-tetramethylrhodamine)carboxylamino)

11 tions GAT-1 is almost insensitive toward the impermeant 2-(trimethylammonium)ethyl methanethiosulfona

12 confirmed by blocking cysteine residues with impermeant 2-sulfonatoethyl methanethiosulfonate.

13 embrane permeant (biotin maleimide (BM)) and impermeant (2-((5(6)-tetramethylrhodamine)carboxylamino)

14 Furthermore, membrane-impermeant [2-(trimethylammonium)ethyl]methanethiosulfon

15 Permeant (300 microM nicotine) and impermeant (5 mM carbachol) cholinergic agents were used

16 [gamma-(32)P]ATP dephosphorylation, and the impermeant AK inhibitor, diadenosine pentaphosphate, red

17 ation of ERK was not inhibited by a membrane impermeant alpha1-blocker, suggesting alpha1 signaling i

18 main(s) based on accessibility to a membrane-impermeant amine-reactive reagent.

19 e was measured by covalent labeling with the impermeant amino reagent, trinitrobenzenesulfonic acid.

20 AMPA/KA receptors or to the existence of AGB-impermeant AMPA/KA receptor complexes.

21 d tamoxifen ethyl bromide (QTam), a membrane impermeant analog of Tam, rapidly induced apoptosis in H

22 A membrane-impermeant analog of tamoxifen, ethylbromide tamoxifen,

23 h Oregon Green maleimide carboxylic acid, an impermeant and fluorescent thiol-reactive agent.

24 QAQ is membrane-impermeant and has no effect on most cells, but it infil

25 n external cysteines were protected with the impermeant and nonfluorescent agent, methanethiosulfonat

26 e cytosol; it is effectively plasma membrane-impermeant and subject to rapid degradation within endos

27 However, because annexins are impermeant and unable to bind PS at low calcium concentr

28 otonated molecule is not completely membrane-impermeant and, therefore, overall drug uptake is less p

29 Small cell impermeants and PEG-20k in LVR solutions increased toler

30 In the presence of the impermeant anion gluconate, glutamate pulses activated s

31 but not when external Cl- was replaced by an impermeant anion.

32 Replacement of the external Cl- with an 'impermeant' anion, such as SO42-, CH3SO3-, gluconate or

33 However, substitution of Cl- by the larger (impermeant) anion gluconate had no effect on the reversa

34 hore Clomeleon demonstrated that cytoplasmic impermeant anions ([A](i)) and polyanionic extracellular

35 nsporters, including KCC2, and extracellular impermeant anions ([A]o) of the extracellular matrix are

36 identified a smaller contribution of fixed, impermeant anions ([A]o) to lowering [Cl(-)]i in RT neur

37 s reduced to 0.9 in solutions comprising the impermeant anions aspartate, methanesulfonate, sulfate,

38 follow a titration of intracellular membrane-impermeant anions by the intracellular accumulation of p

39 ant elements of Cl(-) homeostasis, but local impermeant anions determine the homeostatic set point fo

40 e that, rather than ion transporters, "local impermeant anions establish the neuronal chloride concen

41 sisted in the presence of potassium salts of impermeant anions, and could be abolished by barium, a n

42 erminants of neuronal [Cl(-)]i - cytoplasmic impermeant anions, polyanionic extracellular matrix (ECM

43 complete replacement of external Cl(-) with impermeant anions, tau(c) showed little voltage dependen

44 rge valency (z(x)) of intracellular membrane-impermeant anions, X(-)(i).

45 free external solutions containing different impermeant anions.

46 The cell-impermeant barbiturate N-glucoside amobarbital did not i

47 thelial cells is critical for maintaining an impermeant barrier and epithelial cell polarity.

48 eveloped tight junctions (TJ) to maintain an impermeant barrier and segregate plasma membrane functio

49 Cell surface biotinylation using an impermeant biotinylating reagent confirmed the immunocyt

50 Cell-surface biotinylation using an impermeant biotinylating reagent showed that mutations o

51 of hNET-specific antibodies and the membrane-impermeant biotinylating reagent sulfosuccinimidobiotin

52 An impermeant biotinylating reagent, sulfosuccinimidyl 2-(b

53 Access to a membrane-impermeant biotinylation reagent as well as protease sen

54 ssion of EAAC1, as measured using a membrane impermeant biotinylation reagent combined with Western b

55 virions and could be labeled with a membrane-impermeant biotinylation reagent, indicating surface exp

56 ion of EAAC1 as measured by using a membrane-impermeant biotinylation reagent.

57 when pH was similarly lowered using membrane-impermeant biphthalate.

58 reduced by DTT and reoxidized by a membrane-impermeant bis-quaternary ammonium derivative of diamide

59 blockers of Kir3.1/Kir3.4, but as relatively impermeant blockers of Kir2.1.

60 was mimicked by application of the membrane-impermeant BSA-conjugated DEX, and intracellular blockad

61 regulation, and methylcarbamylcholine (i.e., impermeant but with low efficacy) blocked nicotine induc

62 showed that the hydrophilic dye Alexa 488 is impermeant, but lipophilic FM1-43 labels the seal.

63 ase (CA) inhibitor methazolamide, relatively impermeant CA inhibitor benzolamide, vanilloid receptor

64 Impermeant CA inhibitors abolished net perfusate CO2 los

65 permeant CA inhibitor methazolamide (MTZ) or impermeant CA inhibitors.

66 Membrane-impermeant Ca(2+)-sensitive dye was introduced into the

67 nd identified as inwardly rectifying, proton-impermeant, Ca(2+)-permeant cation channels.

68 ify a family of peptides that carry membrane-impermeant cargos across synthetic membranes.

69 ntial determinations and recordings with the impermeant cation N-methyl-glucamine, this current shows

70 )H]ryanodine binding and the actions of this impermeant cation on the interaction of the reversible r

71 altered by replacement of external Na+ by an impermeant cation, but not when external Cl- was replace

72 n the extracellular Na+ was replaced with an impermeant cation, N-methyl-D-glucamine.

73 helator, 2, 2'-bipyridyl, in contrast to the impermeant chelator bathophenanthroline disulfonate, cau

74 ther Na(+) was replaced by permeant Li(+) or impermeant choline.

75 P, 50 nmol (5 mul)-1), a blood-brain barrier-impermeant cholinergic muscarinic receptor antagonist, e

76 Applying a cell-impermeant click chemistry fluorophore allowed us to vis

77 a small fluorescent chelator whose membrane-impermeant complex with nontoxic Zn(2+) ions binds tight

78 ibition by bathocuproine disulfonate, a cell-impermeant Cu(I) chelator.

79 was sensitive to inhibition by the membrane-impermeant cysteine reagents, MTSET or MTSES, suggesting

80 were tested for sensitivity to the membrane-impermeant cysteine-specific reagent (2-sulfonatoethyl)

81 hese PCFT mutants, were then labeled with an impermeant, cysteine-specific biotinylation reagent (MTS

82 Here we report cytoprotection by a cell-impermeant derivative of strychnine.

83 externally or internally, whereas a membrane-impermeant derivative TRAM-30 blocked the channel only w

84 ck by externally applied quaternary membrane-impermeant derivatives of lidocaine (QX314 and QX222) an

85 ompatible with the observation that membrane-impermeant derivatives of progesterone can induce matura

86 ffected cells remained resistant to membrane-impermeant DNA stains, suggesting that loss of membrane

87 prevented the passage of blood-brain barrier-impermeant drugs (such as morphine, sucrose and mannitol

88 an opportunity for delivery of otherwise BBB impermeant drugs.

89 as shown by staining cells with the membrane-impermeant dye 7-aminoactinomycin D.

90 also delivered the larger, anionic membrane-impermeant dye Alexa Fluor 546 but did not deliver a qua

91 luorescence nuclear staining with a membrane-impermeant dye and by morphologic criteria.

92 ot affect transmural ion conductance or cell-impermeant dye flux but the baseline ion conductance was

93 cone were investigated by using the membrane-impermeant dye FM1-43.

94 Large(myd) myocytes rapidly take up membrane impermeant dye following cyclical cell stretching.

95 (SMTPs) delivered the zwitterionic, membrane-impermeant dye tetramethylrhodamine (TAMRA) into cells e

96 alpain 4-deficient hearts took up a membrane-impermeant dye, Evans blue, indicating plasma membrane d

97 nti-DNA antibodies or an ultrasensitive cell-impermeant dye, YOYO-1, were first developed using Enter

98 These cell-impermeant dyedrons exploit efficient intramolecular ene

99 is was quantified after 60 minutes using the impermeant dyes 7-Aminoactinomycin D and Annexin V.

100 ge in patches of cells positive for membrane impermeant dyes.

101 f islet survival is reproduced by a membrane-impermeant E(2) formulation and a selective GPER agonist

102 The membrane-impermeant E(2)BSA conjugate, shown to bind endothelial

103 These effects were mimicked by the membrane impermeant E2-BSA and selective estrogen receptor modula

104 , and effects a marked reduction in membrane-impermeant estrogen binding with diminished rapid eNOS a

105 Electroporation has been widely used to load impermeant exogenous molecules into cells.

106 secretory granules combined with the use of impermeant extracellular dyes permits direct observation

107 iphenyl-3-yl ester) as the most potent brain-impermeant FAAH inhibitor disclosed to date.

108 Modelling Mg2+ as an impermeant fast open channel blocker indicated that exte

109 ion of bathophenanthroline sulfonate, a cell-impermeant ferrous iron chelator, inhibited Zip14-mediat

110 Results concerning the uptake of membrane-impermeant fluorescent compounds of various sizes are co

111 ty, as observed using membrane-permeant and -impermeant fluorescent DNA dyes.

112 to a peptide solution containing a membrane-impermeant fluorescent dye (carboxyfluorescein), the pep

113 t kinetics were measured by the entry of the impermeant fluorescent dye calcein.

114 The membrane-impermeant fluorescent dye, di-8-ANEPPs spread readily f

115 ion was monitored by the influx of Sytox, an impermeant fluorescent dye, into the Env-expressing cell

116 Photoswitches and membrane-impermeant fluorescent dyes likewise penetrate through P

117 ation was achieved by luminally loading cell-impermeant fluorescent dyes selectively into virtually a

118 easurements and confocal imaging of membrane-impermeant fluorescent indicators therefore represent no

119 Using impermeant fluorescent indicators, capacitance measureme

120 be selectively labeled by applying membrane impermeant fluorescent probes to pre-epiboly and mid-epi

121 IBDUs were perfused in vitro with a membrane-impermeant fluorescent volume marker, fluorescein sulfon

122 The membrane-impermeant fluorescent Zn(2+) probe, 6-CO2H-ZAP4, was lo

123 Photoactivation of a membrane-impermeant, fluorescent steroid analog demonstrates that

124 ct cells were assayed with a novel, membrane-impermeant fluorogenic substrate for vp165, we found tha

125 be achieved by choosing membrane permeant or impermeant fluorogens.

126 uolar perforation by LLO, using the membrane-impermeant fluorophore 8-hydroxypyrene-1,3,6-trisulfonic

127 at room temperature within desiccated water-impermeant foil pouches, and repeated daily application

128 The tubulin-blocked state of VDAC is impermeant for ATP but only partially closed for small i

129 Our data show that membrane-impermeant forms of E2 also activate EC mitogen-activate

130 erminal domain was detected using a membrane-impermeant gel shift reagent to derivatize the Cys resid

131 ns; the effect was also seen with a membrane-impermeant glucocorticoid, but not with intracellular gl

132 g in combination with membrane-permeant and -impermeant Halo dyes allows imaging of integrin endocyto

133 e analogue 3-O-methylglucose (3-OMG), or the impermeant hexitol mannitol-so that the final hexose con

134 The potent activity of the impermeant, highly cathepsin B-specific membrane inhibit

135 As a membrane-impermeant hormone and neurotransmitter, dopamine is tho

136 enous mouse alpha1A, whereas introduction of impermeant human alpha1A hampered the effect of endogeno

137 48 with the elongated ( approximately 29 A), impermeant hydrophilic reagent maleimide-PEG2-biotin.

138 ol reagent shown clearly in this paper to be impermeant in E. coli spheroplasts, was used to identify

139 ation injury, which can be prevented by cell impermeants in low-volume resuscitation solutions.

140 +)], and [Cl(-)] were measured with membrane-impermeant indicators developed by our laboratory, and p

141 oM in pipette solution), which is a membrane-impermeant inhibitor of phosphatases 1 and 2A.

142 rnal CA is achieved by the use of a membrane impermeant inhibitor that was synthesized for this purpo

143 Similar results are obtained with other cell-impermeant inhibitors of sugar uptake.

144 ective osmotic activity of normally membrane-impermeant intracellular anions.

145 The Woodhull model of channel block by an impermeant ion adequately described the actions of exter

146 of K+, Na+ and most of the Cl- with largely impermeant ions (tetraethylammonium, N-methyl-D-glucamin

147 itute instead of the presumably NMDA channel-impermeant ions N-methyl-D-glucamine (NMDG), Tris or suc

148 The selection of impermeant is important and mannitol is significantly su

149 ion, with a solution containing the membrane-impermeant label propidium iodide.

150 MavN cysteine accessibilities to a membrane-impermeant label were determined during macrophage infec

151 neurons by introducing the charged, membrane-impermeant lidocaine derivative QX-314 through the pore

152 ace binding sites for E2, detectable by cell-impermeant ligand binding and equally with an anti-ERalp

153 is mediated at the cell surface because the impermeant ligand tetramethylammonium was as efficacious

154 cells and membrane preparations by membrane-impermeant ligands indicated that 85% of [3H]epibatidine

155 an external access pathway for the membrane-impermeant local anesthetic derivative QX-222 into the i

156 channels can be also blocked by the membrane-impermeant local anesthetic QX via external paths not pr

157 allowing a significant increase in entry of impermeant low and high molecular weight substances from

158 which, in conjunction with appropriate cell-impermeant macroencapsulation devices, may allow such ce

159 t MRI contrast agents are polar and membrane impermeant, making it difficult to deliver them in suffi

160 comparable to values for the macromolecular impermeant marker inulin in both apical-to-basolateral a

161 tubular fluid-to-plasma concentrations of an impermeant marker TF/P in end proximal tubule fluid were

162 BBB uptake of [14C]sucrose (a membrane impermeant marker) and [3H]codeine were investigated usi

163 t the stage for future human studies of skin-impermeant medications and biopharmaceuticals for clinic

164 TM7 were accessible to hydrophilic, membrane-impermeant methanethiosulfonate (MTS) reagents.

165 Reaction of Cys-90 or Cys-306 with impermeant methanethiosulfonate derivatives enhanced dop

166 he introduced sulfhydryl group with membrane-impermeant methanethiosulfonate derivatives inhibited su

167 the accessibility of Cys148 to either NEM or impermeant methanethiosulfonate derivatives is comparabl

168 nate ethylammonium (MTSEA), but not membrane-impermeant methanethiosulfonate ethyltrimethylammonium (

169 all the reagents tested, including membrane impermeant methanethiosulfonate reagents.

170 Membrane-impermeant methanethiosulfonates (MTS) inhibited bile ac

171 This hydrophilic and skin-impermeant molecule was delivered from a TD patch to hea

172 le to the cys-specific, cytoplasmic membrane-impermeant molecule, Oregon Green(R) 488 maleimide (OGM)

173 The internalization of membrane-impermeant molecules (SYTOX green) with cell viability p

174 ose that PMD, by allowing a flux of normally impermeant molecules across the plasma membrane, mediate

175 to label nerve terminals with large membrane-impermeant molecules after addition of BzATP.

176 derived from the HIV TAT protein to membrane-impermeant molecules has gained wide acceptance as a mea

177 , which was originally used to load membrane impermeant molecules into cells in culture, to load conn

178 During skin penetration, membrane-impermeant molecules of a wide range of molecular weight

179 Loading the interstitial space with cell impermeant molecules prevents water movement into the ce

180 Translocation of membrane-impermeant molecules to the interior of living cells is

181 llowing transmembrane transport of otherwise impermeant molecules.

182 utward currents that are carried by normally impermeant monovalent cations such as Cs(+) or K(+).

183 entify a limit to accessibility for membrane-impermeant MTS reagents that may reflect aspects of an o

184 Remarkably, studies with small, impermeant MTSES show that single-Cys replacements in th

185 ble toward chemical modification by membrane-impermeant MTSET reagent, strongly suggesting that trans

186 TM1 accessibility to membrane-impermeant MTSET remains confined to the exofacial half

187 +10 mV; replacement of extracellular Na with impermeant N-methyl-D-glucamine decreased its amplitude

188 -maleimide (large, hydrophilic, and membrane-impermeant), N-ethylmaleimide, 4-acetamido-4'-maleimidyl

189 The impermeant nature of the intestinal barrier is maintaine

190 A membrane impermeant neuroactive steroid modulated receptor activi

191 For both O2 and the impermeant nitroxide, the induced relaxation at the stat

192 an inhibitor of NO synthase, and a membrane-impermeant NO donor that releases NO only upon photolysi

193 entry, showed reduced staining with membrane-impermeant nuclear dyes, and failed to replicate.

194 ing target cells resulted in an influx of an impermeant nucleic acid-staining fluorescent dye into th

195 ubation of resealed ghosts with the membrane-impermeant oxidant ferricyanide doubled the ghost membra

196 The membrane-impermeant oxidant taurine monochloramine, however, had

197 Ellman reagent, a membrane-impermeant oxidizing agent which reacts with exposed cys

198 was accessible to inhibition by the membrane-impermeant pCMPS.

199 disulfide isomerase (PDI) and other membrane-impermeant PDI inhibitors prevented HIV-1 infection.

200 transport, IBDUs were perfused with the cell-impermeant pH-sensitive dye BCECF dextran; luminal pH wa

201 e distinguished using membrane-permeant and -impermeant pharmacological CA inhibitors, while measurin

202 enabling the delivery of otherwise membrane-impermeant polar drugs into cells and tissues.

203 consideration (i.e. the presence of internal impermeant poly-anions, the activity of cation-Cl- cotra

204 Impermeant polymers reduce the conductance in a manner c

205 An impermeant pore mutant abolished BCR-evoked Ca2+ signals

206 Rosiglitazone, a blood-brain barrier-impermeant PPARgamma-selective agonist, elicited antidep

207 Impermeants prevented ischemia-induced cell swelling in

208 ediate access to this region by the membrane-impermeant probe 2-(trimethylammonium)ethyl methanethios

209 accessible from the periplasm to a membrane-impermeant probe in cells with a permeabilized outer mem

210 cellular and can be biotinylated with a cell-impermeant probe.

211 react with both channel-permeant and channel-impermeant probes occupy the outermost extent of TM6 or

212 rom membrane permeant (calcein) and membrane impermeant (propidium iodide) stains.

213 Membrane-impermeant quaternary amine local anesthetics QX314 and

214 Membrane-impermeant quaternary derivatives of lidocaine (QX222 an

215 A membrane-impermeant quencher was used to distinguish intra-PL NBD

216 A membrane impermeant quencher, 2,4,6-trinitrobenzene sulfonic acid

217 The use of a water-soluble membrane impermeant quenching agent in the extracellular space re

218 dized by iron-mediated catalysis to membrane-impermeant quinones and semiquinones.

219 assessed by photolabeling with the membrane-impermeant reagent 2-N-(4-(1-azi-2,2,2-trifluoroethyl)be

220 were sensitive to inhibition by the membrane-impermeant reagent [2-(trimethylammonium)ethyl]-methanet

221 time, and the accessibility of the membrane-impermeant reagent [2-(trimethylammonium)ethyl]methaneth

222 nce after adding the thiol-reactive, bilayer-impermeant reagent methanethiosulfonate ethyltrimethylam

223 to be chemically modified with the membrane-impermeant reagent NHS-biotin.

224 accessible for modification by the membrane-impermeant reagent pCMPS, we hypothesize that eNTPDase3

225 gent N-ethylmaleimide (NEM) and the membrane impermeant reagent polyethyleneglycol maleimide (PEG-mal

226 nt reagent N-ethylmaleimide and the membrane-impermeant reagent polyethyleneglycol maleimide was dete

227 asma membrane proteins were labeled with the impermeant reagent sulfo-N-hydroxysuccinimide-biotin, bo

228 Biotinylation with a membrane-impermeant reagent, separation of the biotinylated/cell

229 GAT-1, but not C399S, very sensitive to this impermeant reagent.

230 n be extracellularly labeled with a membrane-impermeant reagent.

231 de-out vesicles and intact erythrocytes with impermeant reagents and following the outcome by site-di

232 The impermeant reagents MTSES and MTSET react with residues

233 This method allows ready access of otherwise impermeant reagents to the intracellular milieu with min

234 ly diminished after treating cells with cell-impermeant reducing reagents, supporting the presence of

235 within the lipid bilayer, unavailable to an impermeant reporter.

236 thylsulfonate (MTSES) which are permeant and impermeant, respectively.

237 Modelling Ni2+ as an impermeant slow open channel blocker indicated that Ni2+

238 their activity, by introducing the membrane-impermeant sodium channel blocker QX-314 into these axon

239 ity was also probed using Cd(2+), a membrane-impermeant soft metal ion with properties similar to Ag(

240 an be preserved only by a large reduction in impermeant solute concentration within the host cell com

241 hen determined by the intracellular membrane-impermeant solute content (X-i) and its mean charge vale

242 neys and whether this effect is modulated by impermeant solutes included in the preservation solution

243 The effect of impermeant solutes such as NaCl was much less pronounced

244 somes is supplemented with diverse, membrane-impermeant solutes.

245 0% blood volume) with saline or various cell impermeants (sorbitol, raffinose, trehalose, gluconate,

246 serve as filters to exclude anions and other impermeant species from the vicinity of the pore.

247 n of a protein-bound nitroxide by a membrane-impermeant spin relaxant depends on the distance (up to

248 labeled C2cPLA2s and membrane-permeant and -impermeant spin relaxants, we have determined the orient

249 Cytoprotective effects of the cell-impermeant strychnine derivative provide compelling evid

250 inones, and catechol adducts into a membrane-impermeant substance trapped in organelles may provide a

251 zing potency and the penetration efficacy of impermeant substances.

252 sonoporation to deliver calcein, a membrane-impermeant substrate of multidrug resistance protein-1 (

253 from the organism and enhanced access of an impermeant substrate to intracellular alkaline phosphata

254 access of cytosolic ss-galactosidase to its impermeant substrate.

255 other methods and with values for analogous impermeant substrates.

256 re treated in the presence or absence of the impermeant sulfhydryl reagent 4-acetamido-4'-maleimidyls

257 ine potentiated the reaction of the membrane-impermeant sulfhydryl reagent methanethiosulfonate ethyl

258 s, the inhibition of transport by a membrane impermeant sulfhydryl reagent was diminished under condi

259 lity of an endogenous cysteine to a membrane impermeant sulfhydryl reagent was enhanced by the D451E

260 an endogenous cysteine residue to a membrane-impermeant sulfhydryl reagent was increased relative to

261 the reactivity of the mutants to a membrane-impermeant sulfhydryl reagent was not conformationally s

262 ibited by an externally applied and membrane-impermeant sulfhydryl reagent.

263 Cytoplasmically applied membrane-impermeant sulfhydryl reagents alter the Ca2+ sensitivit

264 s probed with membrane-permeant and membrane-impermeant sulfhydryl reagents under a variety of condit

265 o acids to extracellularly applied, membrane-impermeant sulfhydryl reagents.

266 bbeta3, platelets were labeled with membrane-impermeant sulfhydryl reagents.

267 ed by mutagenesis and probed with a membrane-impermeant sulfhydryl-labeling reagent.

268 or C11A mutant secretin receptor with a cell-impermeant sulfhydryl-reactive reagent.

269 hibition of transport activity by a membrane-impermeant sulfhydryl-specific reagent (p-chloromercurib

270 steine-scanning mutagenesis and the membrane-impermeant sulfhydryl-specific reagent, p-chloromercurib

271 incubation of oocytes in the presence of the impermeant sulfhydryl-specific reagent, p-chloromercurib

272 ing and rapid derivatization with a membrane-impermeant, sulfhydryl-specific gel-shift reagent.

273 The modifying reagents, two membrane-impermeant, sulfhydryl-specific methanethiosulfonate der

274 ent-accessibility studies using the membrane-impermeant, sulfhydryl-specific methanethiosulfonate rea

275 eine accessibility method using the membrane-impermeant, sulfhydryl-specific reagent, p-chloromercuri

276 eine accessibility method using the membrane-impermeant, sulfhydryl-specific reagent, p-chloromercuri

277 mutagenesis in conjunction with the membrane-impermeant, sulfhydryl-specific reagent, p-chloromercuri

278 mutagenesis in conjunction with the membrane-impermeant, sulfhydryl-specific reagent, p-chloromercuri

279 mutagenesis in conjunction with the membrane-impermeant, sulfhydryl-specific reagent, p-chloromercuri

280 eine accessibility method using the membrane-impermeant, sulfhydryl-specific reagent, p-chloromercuri

281 hypoxia, an activity which is suppressed by impermeant sulfonamide CA inhibitors.

282 cell monolayer and introduces the ability of impermeant therapeutic agents including high molecular w

283 e use of mass spectrometry with permeant and impermeant thioimidates promises insights into the membr

284 essibility method analysis with the membrane-impermeant thiol reactive reagent p-chloromercuribenzene

285 accessibility of S4 residues to the membrane-impermeant thiol reagent methanethiosulfonate-ethyltrime

286 Methanethiosulfonate ethylsulfonate, an impermeant thiol reagent shown clearly in this paper to

287 fonate ethylsulfonate (MTSES), a hydrophilic impermeant thiol reagent, show that most of the position

288 slocation pathway, that the accessibility to impermeant thiol reagents is influenced (blocked or stim

289 blockage of [14C]NEM labeling with membrane-impermeant thiol reagents such as methanethiosulfonate e

290 cted thiols demonstrated with detergents and impermeant thiol reagents suggests that the protein may

291 ity toward both channel-permeant and channel-impermeant thiol-directed reagents, and patterns of reac

292 in the presence and absence of the membrane-impermeant, thiol-reactive agent p-chloromercuribenzosul

293 o identify wound-associated proteins, a cell-impermeant, thiol-reactive biotinylation reagent was use

294 ine-substituted channels in conjunction with impermeant, thiol-reactive reagents like MTSET+ and MTSE

295 y of TM11 single-cysteine mutants, using the impermeant, thiol-specific reagents, carboxyethyl methan

296 d to the outer leaflet of membranes that are impermeant to dithionite.

297 lungs were filled with liquid containing an impermeant tracer to allow estimation of net liquid move

298 lungs were filled with liquid containing an impermeant tracer, to allow measurement of the rate of n

299 demands both the coinjection of permeant and impermeant tracers followed by the examination of sectio

300 When Na+ was replaced with the impermeant Tris the transducer current increased with ex