ライフサイエンスコーパス: implicate

1 gulation of SIRT1 signaling and mTOR was not implicated.

2 Our results implicate a causal role for accumbal MFN2 on the regulat

3 Our results thus implicate a function of macropinocytosis in mammalian ce

4 Our findings implicate a marked nonvascular disruption in T1D of seve

5 Our results implicate a newly discovered, multidimensional MAPK7/MMP

6 iew, we highlight contemporary findings that implicate a role for flavivirus antibodies in mediating

7 The experiments implicated a concerted PCET mechanism involving intramol

8 the kidney endothelium, in vitro experiments implicated a humoral factor in the anti-inflammatory eff

9 Gene-based rare variant tests implicated a known prostate cancer gene (HOXB13), as wel

10 A gain-of-function mutation implicated a membrane and ESCRT-III regulator, Alx1, in

11 Previous studies have implicated a role for gamma-adducin (ADD3), a cytoskelet

12 Our structure also implicates a unique C-terminal tail of MlaF in self-dime

13 context in a quantitatively meaningful way, implicating a competitive strategy that has been fine-tu

14 ppeared in the compound mouse tumor samples, implicating a novel role of MET in beta-catenin-mediated

15 after FcepsilonR1 stimulation in mast cells, implicating a role in allergy.

16 abolites associated with progression to T2D, implicating AA and phospholipid metabolism.

17 clusion, our findings provide novel insights implicating accumbal Gln and Glu balance on the predicti

18 another sexually dimorphic neuron, pC1d, and implicated aIPg and pC1d neurons as core nodes regulatin

19 gas development (UNGD) to adverse health has implicated air pollution and stress pathways.

20 metabolic changes associated with MacTel and implicate altered lipid metabolism as a contributor to t

21 ynuclein (alphaS), which is both genetically implicated and accumulates in Lewy bodies rich in vesicl

22 diates during immunity and has been recently implicated as a critical factor for immune-initiated cel

23 Interleukin-1 has been implicated as a mediator of recurrent pericarditis.

24 SP6 has also been implicated as an AI candidate gene through its study in

25 Similarly, A20 has recently been implicated as an essential regulator of inflammation in

26 ed in Drosophila, the Hippo pathway has been implicated as an evolutionarily conserved pathway in mam

27 Neural lineages have been implicated as cells of origin, as have glia.

28 Many microbial agents have been implicated as contributors to cancer genesis and develop

29 Ral GTPases have been implicated as critical drivers of cell growth and metast

30 mily of antiviral DNA cytosine deaminases is implicated as the second largest source of mutation in c

31 Atlantic subpolar gyre (SPG) has been widely implicated as the source of large-scale changes in the s

32 y, a novel definition of cancer has emerged, implicating at all stages a complex and dynamic interact

33 Data from our lab implicate autoimmunity to the RNA binding protein (RBP)

34 Research implicates autoimmunity to nonmyelin self-antigens as im

35 Overexpression studies have implicated BC200 and the rodent analog BC1 as negative r

36 Reverse genetic studies implicate both Brugia osm-9 and the cyclic nucleotide-ga

37 Recent studies in humans and animals have implicated brain reward circuits in aggression and sugge

38 , particularly in the mouse brain cell types implicated by the expression patterns of associated gene

39 une cell subsets pivotal to these responses, implicating CD14(+) monocytes in the cholinergic inflamm

40 -type-specific contexts for causal variants, implicating CD4 + effector memory T cells, as well as mo

41 nalysis and cell wall metabolite measurement implicate cell wall metabolism/integrity in betaCA3-medi

42 nd longitudinally, further spirometric loss, implicating cell-cell interactions or overlapping inflam

43 e marrow-transplant, and microglial ablation implicate central and peripheral contributions to K2KO-i

44 Despite extensive examples that implicate classical complement proteins and their recept

45 Previous studies have implicated conserved basic residues in the cytosolic por

46 to bind the CD73 dimer in a bivalent manner, implicating crosslinking of separate CD73 dimers in its

47 Substantial evidence implicates crosstalk between metabolic tissues and the i

48 These results implicate death receptor signaling as an important media

49 enylyl cyclase III in neuroepithelial cilia, implicating deficient pathway repression.

50 ted and validated targets of these microRNAs implicated derepressed TGF-beta signaling as a shared se

51 However, other NMD components are also implicated, distinguishing it from the mammalian system.

52 and palmitoylcarnitine oxidation capacities, implicating dysregulation of CoA-dependent intermediary

53 were abrogated in the presence of 25 mm KCl, implicating enhanced EDH signalling in BRJ- treated anim

54 Taken together, these studies implicate Gal-9 in the regulation of cellular proliferat

55 Newly implicated genes identified in the eQTL analysis include

56 The 20 most frequently implicated genes overall (with prevalence rates per fami

57 Surprisingly, single-cell RNA-Sequencing implicated glia, not neurons, in this effect; there are

58 A number of studies have implicated glycosyltransferases in the pathogenesis of n

59 GSTO1 as a therapeutic target in cancer and implicate GSTO1 in the modulation of tumor growth, immun

60 although the molecular and neuronal pathways implicated have not been fully elucidated.

61 studies of HDAC7 in cultured cardiomyocytes implicated HDAC7 as a prohypertrophic signaling effector

62 using connective tissue disorders, have been implicated; however, the genetic architecture is poorly

63 nt active site with PARP1 or PARP2, our data implicate HPF1 as an important determinant of the respon

64 y palatal mucosa and to identify potentially implicated immunologic pathways.

65 Human studies have implicated impaired glymphatic function in both AD and i

66 tified two clusters - one related to strains implicated in 2016-2017 outbreaks in Pennsylvania and Ne

67 Dense granule protein 12 (GRA12) is implicated in a range of processes related to the establ

68 lar signaling and cell activation, responses implicated in a variety of autoimmune, inflammatory, and

69 ncorporation into cell-surface structures is implicated in a variety of bacteria-host interactions.

70 ophan oxidation in biology has been recently implicated in a vast array of paramount pathogenic condi

71 Autophagy has been implicated in acute kidney injury, which can arise in re

72 E, BACE1, PSEN1, and TREM2, well known genes implicated in AD by previous brain and genetic studies,

73 Members of this MMP family were implicated in AD neuropathology.

74 ative stress and neuroinflammatory responses implicated in AIS pathogenesis [9].

75 he accumulation of amyloid Tau aggregates is implicated in Alzheimer's disease (AD) and other tauopat

76 tal to learning and memory in health and are implicated in Alzheimer's pathogenesis.

77 vidence indicates that early neural measures implicated in anxiety and anxious temperament may be inc

78 Noise-induced neuroinflammation is implicated in auditory processing deficits such as impai

79 cid (GABA) neurotransmission system has been implicated in autism spectrum disorder (ASD).

80 Aberrant OX40 cosignaling has been implicated in autoimmune and inflammatory disorders.

81 as well as SARM1, which has been previously implicated in axonal degeneration (p = 1.76 x 10(-08) wi

82 ed by EAEC, the Pic serine protease has been implicated in bacterial colonization by virtue of its mu

83 as well as countervailing resilience systems implicated in behavioral regulation, and may inform nove

84 For cingulate cortex, a structure implicated in behavioural adaptation and control, a homo

85 oups, we identified one candidate (miR-216a) implicated in beta cell proliferation for subsequent val

86 Common genes implicated in biliary tract cancer tumorigenesis include

87 equivalents in murine ISG15 of 2 aa recently implicated in binding of human ISG15 to LFA-1 in vitro w

88 roles in bioenergetics and metabolism and is implicated in biochemical pathways underlying angiogenes

89 ins, annexin A5, was previously demonstrated implicated in blocking Abeta-induced cytotoxicity in neu

90 versatile transcription factor and has been implicated in both gene-specific regulation and transcri

91 Conversely, ATXN1 loss-of-function is implicated in cancer development and Alzheimer's disease

92 erlying normal tissue regeneration have been implicated in cancer, but the degree of their enactment

93 1,280 co-downregulated genes, including many implicated in cancer.

94 iated with multiple cancers but has not been implicated in CaP thus far.

95 s a nuclear serine/threonine kinase recently implicated in carcinogenesis.

96 The extensive crosstalk with other pathways implicated in cardiomyocyte proliferation calls for the

97 ls: fl-APC increased the expression of genes implicated in cell-cell adhesion, whereas the expression

98 Here, we show that two genes implicated in CHDs, Megf8 and Mgrn1, interact geneticall

99 function, and importantly its dysfunction is implicated in cognitive impairment in humans.

100 tunneling nanotubes, some of which have been implicated in communication defects associated with card

101 luding the regions that have previously been implicated in compass-based navigation.

102 Noncoding RNA molecules have been implicated in critical roles covering a broad range of b

103 fferences between the two ESCRT-III proteins implicated in cytokinesis, CdvB1 and CdvB2.

104 the tightest known binder of KRas, a protein implicated in difficult-to-treat cancers.

105 Th17-mediated immunity has been implicated in disease protection correlates of immune pr

106 ide array of physiological processes and are implicated in disease.

107 in human health, and their misregulation is implicated in disorders ranging from neurodegenerative d

108 ression of a myriad of cell-surface proteins implicated in diverse biological functions, and identify

109 Previously, XRN2 was implicated in DNA double strand break (DSB) repair and i

110 feration and guidance cues that are commonly implicated in dorsal (cortical) patterning(5) in the hyp

111 m supporting soft tissues and sensory organs implicated in either olfactory or thermoregulatory funct

112 onergic gene expression across brain regions implicated in emotion regulation revealed that serotonin

113 nd modulated the expression profile of genes implicated in EMT and metastasis.

114 This recruitment has been implicated in enhanced intact sensory function.

115 Anthropogenic environments have been implicated in enrichment and exchange of antibiotic resi

116 ved in protein synthesis and DNA damage were implicated in etoposide susceptibility.

117 nd their recruitment to inflamed arteries is implicated in events leading to mortality following MI.

118 hment analyses revealed genes and ontologies implicated in glyoxylic acid-mediated ripening, includin

119 rived bacterial lipopolysaccharide (LPS) are implicated in hepatic fibrogenesis.

120 Though LSD1 is implicated in heterochromatin regulation, its function i

121 -containing NMDARs have both previously been implicated in hippocampal synaptic plasticity.

122 e we present a dynamic ranking of host genes implicated in human betacoronavirus infection (SARS-CoV-

123 alterations in brain pathways that have been implicated in human bipolar disorder, and changes in int

124 ads to malignant transformation and has been implicated in human cancers.

125 aryotes and genes that tune PI signaling are implicated in human disease mechanisms.

126 receptors in mammals, but was not previously implicated in IL-17 signaling or nervous system function

127 etate (DMPA) and vaginal dysbiosis have been implicated in increased risk of human immunodeficiency v

128 s factor-like cytokine 1A (TL1A, TNFSF15) is implicated in inflammatory bowel disease, modulating the

129 Changes included reductions in metabolites implicated in insulin resistance (glutamate, -29%; P=1.5

130 3AC is a mammalian neuron-specific kinesin-2 implicated in intracellular cargo transport.

131 atomic models of multiple protein complexes implicated in intraerythrocytic survival of the parasite

132 emerge in tumors and the TME, where they are implicated in invasion, metastasis, and angiogenesis.

133 er, it remains unclear whether they are also implicated in islet vascularization.

134 TrkH is a bacterial ion channel implicated in K(+) uptake and pH regulation.

135 memory and cognitive control, have long been implicated in language comprehension, including in neuro

136 as a diverse array of spliceoforms, has been implicated in linking the AJ and TJ complex to the cytos

137 llular localization and function of proteins implicated in LSDs.

138 chondrial oxidative phosphorylation has been implicated in macrophage polarization.

139 ott Aldrich syndrome protein (WASp) has been implicated in maintenance of the autophagy-inflammasome

140 in medial prefrontal cortex (mPFC) has been implicated in major depressive disorder.

141 Sphingolipids have been implicated in mammalian placental development and functi

142 s) to reduce protein synthesis and have been implicated in many diseases, including OA.

143 The gut microbiome has been causally implicated in many immune-mediated diseases.

144 s by plant populations, known as masting, is implicated in many important ecological processes, but h

145 highly vulnerable to stressors and have been implicated in many neuro-psychiatric diseases such as sc

146 osatrienoic acids, which, in turn, have been implicated in mediating several cardiovascular condition

147 ciated with lipid metabolism are known to be implicated in MNDs, there remains a lack of clarity rega

148 se-causing mutations in known genes that are implicated in monogenic PID occurred in 10.3% of these p

149 Although CD4+ T cells are implicated in MS pathogenesis and have been the main foc

150 cancer types, both in vitro and in vivo, and implicated in multiple processes associated with metasta

151 ferase-like protein 21C (METTL21C) is a PKMT implicated in muscle biology that has been reported to m

152 ritical regulators of muscle development and implicated in neoplastic transformation.

153 ction mechanisms to induce pathways that are implicated in neural degeneration(3-9).

154 The human Msp1 homologue has been implicated in neurodegenerative diseases, and we show th

155 Dysregulation of TrkB signaling is implicated in neurodegenerative disorders and cancers.

156 While other HDAC complexes have been implicated in neurogenesis, the physiological role of Mi

157 Moreover, disruption of these pathways is implicated in neuromuscular disease, and the recent deve

158 ual phenotype, and nine have previously been implicated in nonalcoholic fatty liver disease.

159 id aggregation of alpha-synuclein, a protein implicated in Parkinson's disease that predominately nuc

160 ies shed light on the neurocognitive domains implicated in PD-ICBs and identify psychosocial determin

161 hesized that the u-opioid system-extensively implicated in placebo effects, a clinical phenomenon tho

162 un binding, and upregulation of nearby genes implicated in progeria pathophysiology.

163 complement activity, all of which have been implicated in protection against influenza, have yet to

164 Rather, the RG/RGG domain is implicated in providing essential contributions to RNA-b

165 em, the primary target of cannabis, has been implicated in psychosis.

166 ullination of histones by PADI4 was recently implicated in regulating embryonic stem and hematopoieti

167 BMPs are multifunctional growth factors implicated in regulating the ovarian function as key int

168 cardiac transcription factor not previously implicated in regulation of adult cardiac metabolism.

169 ator of virulence genes, has been previously implicated in regulation of prfA, but this site was weak

170 partment within the dorsal striatum has been implicated in reinforcement learning and regulation of m

171 d (AHL) transcription factor family has been implicated in restricting rosette growth in response to

172 RNAP delta subunit and NTPase HelD have been implicated in RNAP recycling.

173 alysis identifies novel genes not previously implicated in schizophrenia and corroborates a number of

174 ased glutamate levels in thalamus seem to be implicated in schizophrenia pathophysiology.

175 ns, and various flagellar proteins have been implicated in sensing roles.

176 pathways in the brain reward center that are implicated in sensory and affective manifestations of ch

177 tor is important in many brain functions and implicated in several neurological pathologies.

178 xpression level of alpha2delta subunits were implicated in several syndromes and diseases, including

179 SLN has also been implicated in skeletal muscle thermogenesis.

180 hat Syt2a localizes to synapses onto neurons implicated in social behavior in the ventral forebrain a

181 e superior temporal sulcus (mSTS)-previously implicated in social perception-signaled strategic infor

182 n in the epidermis and mesophyll of isozymes implicated in starch and malate turnover are discussed i

183 mutants lacking both SS5 and other proteins implicated in starch granule initiation allows us to pro

184 (6.1%) involving seven genes that have been implicated in stillbirth and six disease genes that are

185 uneus and hippocampus, which are key regions implicated in structural brain changes in dementia.

186 dopaminergic systems have independently been implicated in substance use disorder and obesity.

187 e conclude that blunted interoception may be implicated in suicidal behavior.

188 ic risk for PTSD symptoms, and a novel locus implicated in synaptic transmission and plasticity may s

189 or deletion of a key NMDAR subunit, GluN2B, implicated in the actions of ketamine.

190 Because multiple factors are implicated in the aetiology of delirium, there are likel

191 ng the structural subcomponents and proteins implicated in the biogenesis and stability of the apical

192 Cardiac autonomic dysregulation has been implicated in the comorbidity of major psychiatric disor

193 Histone-modifying enzymes are implicated in the control of diverse DNA-templated proce

194 Deregulated overexpression of MYC is implicated in the development and malignant progression

195 tic copy number aberrations (CNAs) have been implicated in the development and progression of various

196 at deregulation of the SPECC1L gene could be implicated in the development of ocular coloboma.

197 59 of the envelope (E) protein is reportedly implicated in the different levels of neurovirulence in

198 HELLS has been implicated in the DNA damage response, but its mechanist

199 oupled second-messenger systems and RUFY3 is implicated in the establishment of neuronal polarity and

200 and functionally diverse proteins have been implicated in the granule initiation process in Arabidop

201 The factors implicated in the initiation and progression of tau misf

202 torm and acute respiratory distress syndrome implicated in the most severe cases.

203 Mitochondrial dysfunction has long been implicated in the neurodegenerative disorder Parkinson's

204 ven inflammatory disorders and has also been implicated in the pathogenesis of gastrointestinal (GI)-

205 rs of endothelial activation, which has been implicated in the pathogenesis of heart failure (HF) wit

206 P53 has been implicated in the pathogenesis of obesity and diabetes;

207 or reductions in GABAergic interneurons are implicated in the pathology of severe neuropsychiatric d

208 ion of prefrontal cortex maturation has been implicated in the pathophysiology of cognitive deficits

209 n white matter (WM) microstructure have been implicated in the pathophysiology of major depressive di

210 ulating gene expression, miRNAs are strongly implicated in the pathophysiology of many complex diseas

211 Insect OBPs are implicated in the perception, storage and transport of c

212 roles in inflammation, plasminogen has been implicated in the progression of a wide range of disease

213 y pathway of protein quality control that is implicated in the proteotoxicity-associated neurodegener

214 h expresses a distinct set of genes that are implicated in the recognition, phagocytosis and/or endoc

215 The commensal microbiota has been implicated in the regulation of a diverse array of physi

216 Oxytocin-like peptides have been implicated in the regulation of a wide range of social b

217 or (OTU) subfamily deubiquitinases have been implicated in the regulation of critical cell-signaling

218 While parkin has been implicated in the regulation of mitophagy and proteasoma

219 lthough matrix metalloproteinases (MMPs) are implicated in the regulation of numerous physiological p

220 sex-dependent alterations in brain circuitry implicated in the regulation of the stress response are

221 Consistent with this, PNKP is implicated in the repair of both DNA single-strand break

222 atal-thalamic-cortical (CSTC) brain circuits implicated in the selection of movements, impaired opera

223 Every major immune cell subset has been implicated in the unresolved inflammation of PD, regardl

224 One mechanism that has been implicated in this cross-linking is glycation through fo

225 - fumarate, succinate and L-2-HG - have been implicated in this disease process.

226 isruption of brain components not previously implicated in this disorder: hypothalamic melanin-concen

227 While six genes have been implicated in this hereditary condition (MFRP, PRSS56, M

228 These enzymes have also been implicated in tumor progression and metastatic disease a

229 Dysregulation of this homeostasis is implicated in tumorigenesis and acquired resistance to t

230 rograde transport of this organelle has been implicated in turnover of aged organelles through lysoso

231 e citric cycle intermediate succinate and is implicated in various pathological conditions such as rh

232 hysiological processes, and are consequently implicated in various pathologies.

233 omain-containing protein 1 (SMCHD1) has been implicated in X-chromosome inactivation, imprinting, and

234 result in immune activation or, as recently implicated, in providing an exit route for tumour cell d

235 Despite mounting evidence implicating inflammation in cardiovascular diseases, att

236 These data implicate inhibition of the cmA as a common denominator

237 iations in sporadic human prion disease that implicate intracellular trafficking and sphingolipid met

238 efine the primary aldosteronism syndrome and implicate it in the pathogenesis of "essential" hyperten

239 005 <= p <= 0.04, 11.8 <= MAF <= 40.9%), and implicated its interaction with ERCC8 (joint effect: 3.0

240 within skin-specific regulatory elements and implicate loci involved in cancer development, immune re

241 Forced heterochromatin formation at implicated loci confirms that resistance results from he

242 associations with MDD in human samples that implicated many closely related biological pathways.

243 We identify the implicated mechanisms, which involve alpha-catenin captu

244 of chronic kidney disease (CKD) progression, implicating mechanisms beyond renal clearance.

245 stimuli when sounds were separated in time, implicating memory representations unique to harmonic so

246 Our findings implicate more than 5% of all protein-coding genes and p

247 We implicate MPO as an inflammatory modulator in humans tha

248 genital NAD deficiency disorders and further implicate mutation of additional genes involved in de no

249 Furthermore, the implicated mutations are predominantly located at five r

250 are enriched in myeloid-specific enhancers, implicating myeloid cells in AD etiology.

251 These findings implicate Na(V)1.7 as a key pharmacotherapeutic target f

252 ratio in ilea from Msi1-overexpressing mice implicated Notch signaling in inducing enterocyte differ

253 Results strongly implicate opioids in gregarious song and suggest that en

254 Our data implicate PfAP2-G not only as a transcriptional activato

255 itin proteasome system (UPS) components have implicated protein degradation.

256 Converging evidence implicates redox dysregulation as a pathological mechani

257 oint "mutations" in cancer-related genes and implicated selective culture conditions.

258 ive for the apoptotic suppressor ced-9/Bcl-2 implicating SEP-1 in execution of apoptosis.

259 with severe spine segmentation defects have implicated several human orthologues of cyclic genes tha

260 unctions associated with EAE susceptibility, implicating short-chain fatty acid metabolism as a key e

261 ved enrichment of transcription factors that implicated SMAD and JDP2 in BCC pathogenesis and FOXP1 i

262 ST2 axis in bronchial epithelial repair, and implicate ST2 in myeloid cell differentiation.

263 Although studies have implicated SYNGAP1 in several cognitive disorders, it is

264 Multiple observations implicate T-cell dysregulation as a central event in the

265 Our work implicates TBX3 as context-dependent component of the Wn

266 Our findings implicate that the HSP90A-TCL1A-AKT pathway ignited by N

267 ysis of SELEX publications spanning 13 years implicate the alkaline denaturation step as a significan

268 These changes implicate the brainstem's breathing circuitry which we c

269 Our findings implicate the E. coli host 3'-5' exonucleases DnaQ and E

270 These findings implicate the involvement of macrophage AQP3 in liver in

271 affect and dysphoria, but recent studies now implicate the kappa opioid system in the modulation of n

272 support a role for CLRs in autoimmunity and implicate the MCL/MINCLE pathway as a potential therapeu

273 These data causally implicate the minority striatal fast-spiking interneuron

274 Strong evidences have implicated the high dependence of CDR on tumor genomic a

275 Previously, our laboratory implicated the histone demethylase LSD1 in tau-induced n

276 Recent evidence has implicated the nervous system and glial family ligands (

277 ted chromatin accessibility changes, we have implicated the transcription factor KLF5 in the transiti

278 sition of cortical interneurons, and further implicates the JNK pathway as an important regulator of

279 last 20 years, evidence has accumulated that implicates the N-terminus of Abeta as a region that may

280 Substantial evidence implicates the nucleus accumbens in motivated performanc

281 reveal gene function-associated noise trends implicating the action of natural selection.

282 racusis can also occur without hearing loss, implicating the central nervous system in the generation

283 r neurotensin exhibited increased REM sleep, implicating the involvement of the neuropeptide itself.

284 D on human AHN and analyse different studies implicating the role of human AHN as a potential converg

285 pproach using previous evidence in the field implicating them in AD.

286 diverse cellular and developmental pathways, implicating them in many diseases besides cancer, includ

287 ty of animal species (except mice and rats), implicating these animal species as possible intermediat

288 e additionally survey the growing literature implicating these proteins in various neurological disor

289 Our results implicate theta oscillations across the MTL as a common

290 activation of Crkl in mice causes CTDs, thus implicating this gene as a modifier.

291 which was reduced by the R289A substitution, implicating this interaction in the observed processing

292 Genome-wide association studies have implicated thousands of noncoding variants across common

293 pressed below tight junctions (TJ), strongly implicating TJ disruption as a critical step in antigen

294 Although BAT has been implicated to be protective in cardiovascular disease, t

295 Our findings also implicate TrkB signaling in the complex pathology of TSC

296 ro, while next generation sequencing broadly implicates TrkB.T1 in the PI3K signaling cascades in a l

297 These findings strongly implicate TSPAN-7 as a key regulator in determining the

298 Together this implicates UBR5 in regulating TTC7A signaling in VEOIBD

299 These findings implicate up-regulated ST6Gal-I expression in blocking h

300 -infiltrating T cells following Yap deletion implicates Yap as a mediator of global T-cell responses