ライフサイエンスコーパス: importer

1 CC1, the gene that encodes the vacuolar iron importer.

2 siologically stimulates DMT1, the major iron importer.

3 at PlaP functioned as the primary putrescine importer.

4 e transport of small substrates by a Type II importer.

5 ption of CCC1, which encodes a vacuolar iron importer.

6 pression was mntH, which encodes a manganese importer.

7 cidental, occurring via some essential metal importer.

8 nd the plasma membrane acts as a cholesterol importer.

9 ntrols succeed in lowering the amount of the importer.

10 eat peptides to the surface of NTF2, the Ran importer.

11 ll indicating that Zip14 functions as a zinc importer.

12 it is inferred that BldK is an oligopeptide importer.

13 of adeP expression, which encodes an adenine importer.

14 turated and monounsaturated FAs via the Mce1 importer.

15 mission intensities between the exporter and importer.

16 acts as a proton-activated, lysosomal Ca(2+) importer.

17 nctional ortholog of HNM1, the yeast choline importer.

18 peptides, suggesting a role as an amino acid importer.

19 et emission exporter to being a net emission importer.

20 ly protein Pic2 in budding yeast is a copper importer.

21 c staphylococcal species do not possess this importer.

22 48 are part of a previously unidentified DNA importer.

23 S4, genes that encode the mitochondrial iron importers.

24 port mechanism between ABC exporters and ABC importers.

25 orter MalFGK(2) is a study prototype for ABC importers.

26 associated with elevated expression of zinc importers.

27 cription factors, alpha-tubulin, and nuclear importers.

28 ions through transcription of genes for zinc importers.

29 for improved requirements for US OTC product importers.

30 t exporters of health impacts, other are net importers.

31 pand the understanding of subcellular Ca(2+) importers.

32 the high-level expression of sulfur-compound importers.

33 hereas FLVCR2 was suggested to act as a haem importer(13), yet conclusive biochemical and detailed mo

34 Introduction of this D/E-P motif into malate importer, ABCB14, increases both its malate and its back

35 In this study, we demonstrate that two ABA importers, ABCG17 and ABCG18, control seed size by regul

36 Type II importers accept substrates in a nucleotide-free state,

37 1 (CTR1) is the primary high-affinity copper importer, although its mechanism and role in Cu(II) redu

38 The Escherichia coli MetNI-Q importer, an ATP-binding cassette (ABC) transporter, med

39 ltose importer is an example of a type I ABC importer and a model system for this class of ABC transp

40 as well as by specialized membrane-spanning importer and exporter channels.

41 as a microglia-enriched plasma membrane heme importer and provides a genetic platform to identify met

42 vation activates transcription of the biotin importer and simultaneously represses transcription of t

43 least partially dependent on the YfhA YfiYZ importer and the YusV ATPase.

44 ibactin and enterobactin requires the FeuABC importer and the YusV ATPase.

45 o the intensive care unit (ICU) and 11.4% in importers and 11.7% in acquirers who were admitted direc

46 95% confidence interval [CI], 26.5-32.9) for importers and 28.8 (95% CI, 23.5-35.3) for acquirers com

47 MRSA pre- and postdischarge infections among importers and 61.2% among acquirers occurred within 180

48 80-day postdischarge time period was 5.5% in importers and 7.0% in acquirers without a direct admissi

49 ajor ABC transporter folds, namely large ABC importers and ABC exporters.

50 ncrease the abundance and activity of Mg(2+) importers and decrease the abundance of Mg(2+)-chelating

51 tissue, the process in which both amino acid importers and exporters are expected to be involved.

52 porters it seems likely that the TMDs of ABC importers and exporters have evolved different mechanism

53 Our findings identify potential importers and exporters of hydrogen or, conversely, expo

54 In this transition, the vacuolar Suc importers and exporters TONOPLAST SUGAR TRANSPORTER2;1 a

55 2-5A was also transferred through importers and exporters, allowing OAS to remotely activa

56 Ps) are associated with ATP-binding cassette importers and switch from an open to a closed conformati

57 RIT-seq profiling identifies both known drug importers and the only known pro-drug activator, and lin

58 established between countries (exporters or importers) and industries.

59 ized, those who were colonized on admission (importers), and those who acquired MRSA during their sta

60 Both CTR1, a copper importer, and ATP7A, a copper transporter across membran

61 three proteins by inducing MntH, a manganese importer, and Dps, an iron-sequestration protein.

62 e, Abcb6 is the sole ATP-dependent porphyrin importer, and loss of Abcb6 produces up-regulation of he

63 n homeostasis genes, psaBCA, encoding the Mn importer, and mntE, encoding the Mn exporter, lead to Mn

64 Julia-based tools: SBMLImporter.jl, an SBML importer, and PEtab.jl, an importer for parameter estima

65 ompensates for the loss of Msc2p, an ER zinc importer, and therefore helps to alleviate ER stress.

66 n between hydrogen exporting firms, hydrogen importers, and domestic electricity consumers and hereby

67 ing siderophores and membrane-spanning metal importers, and the biological specificity of allosteric

68 ogether with fhuCDB, encoding the aerobactin importer are sufficient to convert V. harveyi into an "a

69 n differences in structure and activity, ABC importers are divided into two types.

70 Bacterial ATP-binding cassette (ABC) importers are primary active transporters that are criti

71 nd Extremadura, while the main virtual water importers are the industrialized regions of Madrid, Basq

72 eficiency, whereas the energy-dependent zinc importers are upregulated during severe zinc deficiency.

73 1, which activates the Ctr4 high affinity Cu importer, are hypo-virulent in mouse models.

74 al., identifying the mitochondrial glutamine importer as a variant of SLC1A5.

75 MFe(hi) ATMs and the gene expression of iron importers as well as the iron exporter, ferroportin, sug

76 nctional traits with both type I and type II importers, as well as possessing unique features, and em

77 in April 2018 and charges manufacturers and importers at pound 0.24 per litre for drinks with over 8

78 y, 89 countries analyzed were net blue water importers at the national level.

79 The auxin importer AUX1 functions as a positive regulator of cytok

80 increase localized accumulation of the auxin importer AUXIN TRANSPORTER PROTEIN1 (AUX1) and the auxin

81 been observed in studies of the vitamin B12 importer BtuC2D2.

82 richia coli vitamin B12 ATP-binding cassette importer BtuCD-F.

83 usly observed for the homologous vitamin B12 importer BtuCD.

84 not found in the structures of three solute importers BtuCD, HI1470/1, and ModBC from the same prote

85 vels is independent of the major cellular Cu importer but is dependent on the Fe importer Ftr1 and it

86 rmally known as HI1470/71) is also a Type II importer, but its substrate, molybdate, is approximately

87 We previously identified SLC19A1 as a cGAMP importer, but its use across human cell lines is limited

88 Bacillus subtilis expresses numerous iron importers, but iron efflux has not been reported.

89 Less is known about Type II importers, but much of what we do know has been observed

90 EmrE, a drug/H(+) antiporter to a polyamine importer by a single mutation.

91 cation of ASOs with a small-molecule nuclear importer can significantly improve target engagement and

92 ed on structural and functional studies, ABC importers can be divided into two distinct classes, type

93 nvolved in vacuolar iron storage is the iron importer Ccc1, which facilitates iron entry into the vac

94 rs affects the activity of the vacuolar iron importer Ccc1.

95 mic studies of the bacterial MFS-type copper importer CcoA, required for cbb(3)-type cytochrome c oxi

96 d metabolism genes identified the fatty acid importer CD36 as highly expressed in Treg but not Teff f

97 he previously described Msc2p-Zrg17p ER zinc importer complex functions mainly in zinc-depleted condi

98 ng the required cycling rate, which balances importers' costs and recycling revenues, we find that th

99 Evidence of the role of the endothelial Cu importer CTR1 (also known as SLC31A1) in VEGFR2 signalli

100 r copper is regulated not only by the copper importer CTR1 (copper transporter 1) but also by the cop

101 eak transcriptional repression of the copper importer CTR1 and ii) CREB activity is inversely correla

102 ors MAC1 and ACE1, the MAC1-dependent copper importer CTR1, and other copper proteins considered coll

103 etion, differential expression of the copper importer CTR1, and redox stress induced by manipulating

104 ses alveolar macrophage expression of the Cu importer (Ctr1) and ATP7A, a transporter implicated in p

105 rease expression of the high affinity copper importer, CTR1, and stimulate copper uptake.

106 iron uptake and the mRNA expression of iron importer divalent metal transporter 1 (DMT1) were signif

107 microglia preferentially upregulate the iron importer, divalent metal transporter 1 (DMT1, gene name

108 everal iron transporters, including the iron importer DMT1 (Ireg1, MTP, DCT1) and the iron exporter f

109 Thus, if major tropical commodity importers (e.g., the EU) require traders to eliminate de

110 polypeptide (OATP), which we named Ecdysone Importer (EcI), is required for cellular uptake of the p

111 induces both a miniferritin and a manganese importer, enabling the replacement of the iron atom in t

112 The substrate selectivity of this importer ensures the high-affinity uptake of essential m

113 unctions as the principal mitochondrial iron importer essential for haem biosynthesis in vertebrate e

114 -K(+)-Cl(-) cotransporter 1 (NKCC1), a Cl(-) importer expressed in most cell types mainly during post

115 xpression, and towards regions of high auxin importer expression.

116 of all bacteria, ATP binding cassette (ABC) importers facilitate the uptake of several vital nutrien

117 Currently, the 27 registered importer facilities import approximately 8500 nonhuman p

118 Importer facilities receive regular inspections, and com

119 during transit and quarantine and initiated importer facility compliance inspections.

120 ed with increased expression of the Zn(2)(+) importer family members Slc39a6, Slc39a7, and Slc39a8, a

121 and delivers it to the ATP-binding cassette importer FeuBC, which is involved in bacterial iron upta

122 Type I importers follow a strict alternating access mechanism t

123 suggested that Yfe, a well-characterized C9 importer for manganese (Mn) and iron in Y. pestis, might

124 12 is an essential component of the cysteine importer for melanosomes and lysosomes.

125 an operon and is predicted to encode an ABC importer for nutrient uptake (e.g., amino acids).

126 orter.jl, an SBML importer, and PEtab.jl, an importer for parameter estimation problems in the PEtab

127 ner membrane, functions as an essential iron importer for the synthesis of mitochondrial heme and iro

128 ere, we identify RagAB as the outer-membrane importer for these peptides.

129 Escherichia coli maltose transporter, an ABC importer for which an intact structure is available both

130 an electroneutral Na(+)-dependent HCO(3)(-) importer for which the precise mode of action remains un

131 fitness in NHP myositis, including putative importers for amino acids, carbohydrates, and vitamins a

132 edicted to homodimerize and form peroxisomal importers for fatty acyl-CoAs.

133 28) function as essential mitochondrial iron importers for heme and Fe/S cluster biogenesis.

134 exclusion from these bodies, and can act as importers for otherwise-excluded nucleic acids, which su

135 We identified key exporters and importers from the number of shipments a country sent an

136 lular Cu importer but is dependent on the Fe importer Ftr1 and its partner Fet3, a multicopper oxidas

137 tide importer (oppABCDF) and glycine betaine importer (gbuABC) allowed DeltadacA mutants to grow in r

138 tion, which has two inorganic phosphate (Pi) importers, genomic analysis suggested that S. aureus pos

139 Mutants that lack MntH, the importer, grow at wild-type rates, indicating that manga

140 nial vault, expressed high levels of lactate importers, harbored abundant mitochondria, metabolized l

141 er acidic conditions, although a low-pH Fe2+ importer has not been previously identified.

142 The human high affinity copper importer, hCtr1, and its yeast and murine orthologues ha

143 raction between the Yersinia pestis ABC heme importer (HmuUV) and its partner substrate-binding prote

144 rs fundamentally from that of the human Ubc9-importer Importin 13.

145 However, the limited market share of importers imposing such restrictions and the potential f

146 ion-an example of a lysosome-specific Ca(2+) importer in animals.

147 Divalent Metal Transporter1, a major iron importer in cells, is stimulated by signaling of Dexras1

148 ing domains (SBD) of an ATP-Binding Cassette importer in real-time.

149 ed by using Texas as an example, the largest importer in the U.S. grain transfer network.

150 like proteins (ZIPs) represent the only zinc importers in metazoans.

151 activity of putative vacuolar glucosinolate importers in these peripheral cell layers.

152 I region could benefit, or by major palm oil importers, in which case M&I loses income.

153 colocalization with the principal root iron importer IRON-REGULATED TRANSPORTER1 (IRT1).

154 The Escherichia coli MalFGK(2)E maltose importer is an example of a type I ABC importer and a mo

155 The MAC1-independent importer is predicted to be FET4, a nonspecific importer

156 The MalFGK(2)E importer is responsible for the intake of malto-oligossa

157 CCC1, a vacuolar iron importer, is a Yap5-regulated gene, and deletion of eith

158 d, and transferrin receptor (TFR1), the iron importer, is increased in tumor tissue from patients wit

159 t distinctly different from the three solute importers it seems likely that the TMDs of ABC importers

160 h a potent and proven small-molecule nuclear importer, (+)-JQ1.

161 Mutating the nuclear importer karyopherin alpha3 also leads to reduced toxici

162 We identify the potassium importer KimA from Bacillus subtilis as a member of the

163 alent metal transporter 1 (DMT1) as a Cu(II) importer, labile Cu(II) increases in response to oxidati

164 oncurrently, ectopic expression of the auxin importer LIKE AUX1 and boundary gene NO APICAL MERISTEM

165 l structures of the Escherichia coli maltose importer (MalFGK2) in complex with its substrate binding

166 diseases, and knowledge of lysosomal Ca(2+) importers may provide previously unidentified avenues to

167 ting that ATP-binding cassette exporters and importers may use similar mechanisms to achieve alternat

168 ransport cycle, shedding light on ABC type I importer mechanisms.

169 ransporter subunit OpuCA, the primary Mg(2+) importer MgtE, and DarB (YkuL), a protein of unknown fun

170 imilarity to the Ctr1 plasma membrane copper importer, microscopic and biochemical fractionation stud

171 logs suggests that MFS-type bacterial copper importers might be species-specific.

172 vertebrate mitochondrial high-affinity iron importers, mitoferrin1 (Mfrn1) and Mfrn2, have been iden

173 taphylococcus aureus possesses two manganese importers, MntH and MntABC.

174 sion of the high-affinity mitochondrial iron importer Mrs3.

175 able to interact with nodule-specific Cu(+) -importer MtCOPT1.

176 ble interest in using bumetanide, a chloride importer Na-K-Cl cotransporter antagonist, for treatment

177 However, common BA importers (Na(+)/taurocholate cotransporting polypeptide

178 ulated by the action of the Na(+)-K(+)-Cl(-) importer NKCC1 and the K(+)-Cl(-) exporter KCC2.

179 report that local abundance of the chloride importer NKCC1 and timely emergence of GABAergic inhibit

180 o auxin exporters, leaves also express auxin importers, notably members of the AUX1/LAX family.

181 spersive X-ray analysis we show that two GLS importers, NPF2.10/GTR1 and NPF2.11/GTR2, are critical f

182 movement of other molecules, such as the Ran importer NTF2.

183 ceptor (IFNGR)-1/STAT1alpha with the nuclear importer nucleoprotein interactor 1.

184 s now as an electrochemical potential driven importer of a new set of substrates: aliphatic polyamine

185 orter is predicted to be FET4, a nonspecific importer of both Cu and Fe.

186 en, we identified SLC19A1 as the first known importer of cGAMP and other CDNs, including the investig

187 entry and a conserved protein, PicA (Protein importer of chimalliviruses A), that facilitates cargo p

188 nd has therefore been proposed to be a major importer of dietary fatty acids.

189 The MetNI methionine importer of Escherichia coli, an ATP binding cassette (A

190 mitoyl transferase 1 (CPT1), a mitochondrial importer of fatty acids, reveal that many oxylipins are

191 a Philippine fishing community that is a net importer of fish, we show that a government cash transfe

192 r (hRFC, also known as SLC19A1) is the major importer of folates into the cell(1,3), as well as chemo

193 The largest center was a net importer of kidneys, whereas small and medium-sized cent

194 adding the tgd1 mutation, which disables an importer of lipids into plastids to create adg1suc2tt4tg

195 e, PAPST2 represents an important organellar importer of PAP, providing a piece of the puzzle in our

196 ed Transportin-3 (TNPO3) as the main nuclear importer of RBM20.

197 Therefore, Kap114 is an importer of TBP into the nucleus, but alternative import

198 uABCD (also called OpuC) encodes a predicted importer of the compatible solute glycine betaine.

199 The results reveal that Spain is a net importer of water.

200 ATP binding by Type I ABC transporters (importers of amino acids, sugars, peptides, and small io

201 ve exporting industries have argued that the importers of emissions-intensive goods should bear the r

202 Seventy-six countries are net importers of extinction-risk footprint, 16 countries are

203 Here we compared two ABC importers of identical substrate specificity (molybdate/

204 ers of hydrogen or, conversely, exporters or importers of industries that would rely on electrolytic

205 hai, Beijing, and Tianjin, are already large importers of net virtual water at the expense of water r

206 riginally believed to be present only in the importers of the ABC family.

207 In Type II ABC transporters (importers of trace elements, e.g. vitamin B12, heme, and

208 and accordingly, bacterial ABC transporters (importers) of metals are key virulence determinants.

209 tified TMEM165 as a proton-activated calcium importer on the lysosome, thus discovering a key player

210 ss of function mutations in the oligopeptide importer (oppABCDF) and glycine betaine importer (gbuABC

211 omain of the ATPase subunit of the carnitine importer OpuC.

212 ountries and territories that acted as major importers or exporters, the best-connected traders, the

213 A GFP fusion to the choline importer protein LicB showed clear membrane localization

214 Protein abundance of the heme importer, proton-coupled folate transporter, was related

215 cation of TMEM14C as a protoporphyrinogen IX importer provides a genetic tool for further exploring e

216 the conformational plasticity of the maltose importer, providing insights into the ATPase stimulation

217 en Streptococcus pneumoniae, the Mn-specific importer PsaBCA, exporter MntE, and transcriptional regu

218 In addition to these exporters, one importer, Pseudomonas aeruginosa Q9I147, was also identi

219 oding a highly conserved inorganic phosphate importer, PstSCAB, increases the sensitivity of Staphylo

220 ess was not ascribed to a defect in a single importer; rather, there was a collective impairment in t

221 ) and a reduced KCC2/NKCC1 (Na(+)/K(+)/Cl(-) importer) ratio.

222 mic polyamine sensor, and PotD1, a polyamine importer, regulate V. cholerae biofilm dispersal.

223 )-Cl(-) cotransporters functions as an anion importers, regulating trans-epithelial chloride secretio

224 cortical LDL receptor (LDL-R; a cholesterol importer) regulation was gauged by quantifying its mRNA.

225 Zinc transporter ZIP4 (ZIP4) is a zinc importer required for dietary zinc uptake in the intesti

226 TNPO3 is a nuclear importer required for HIV-1 infection.

227 used by mutations in hZIP4 (SLC39A4), a zinc importer required for zinc uptake in enterocytes and oth

228 This importer requires a periplasmic maltose-binding protein

229 with the exception of a TM-localized copper importer, resided in the plasma membrane (PM).

230 binding protein and the CopD putative copper importer, respectively, whereas YebY belongs to the unch

231 NKCC1, which serve as chloride exporters and importers, respectively.

232 arum RibN as bona fide copper and riboflavin importers, respectively.

233 mbers of a highly conserved family of copper importers responsible for copper uptake across the plasm

234 ion of CCC1, which encodes the vacuolar iron importer, results in high iron sensitivity due to increa

235 These three structural motifs in small ABC importers show a high degree of correlation in motion an

236 over that cytosolic import through the dsRNA importer SID-1 in the parental germline and/or developin

237 in the germline requires the dsRNA-selective importer SID-1.

238 emic/exogenous (exo)-RNAi pathway: the dsRNA importer, SID-1 and the argonaute, RDE-1.

239 , with particular emphasis on the binding of importer SLC19A1 to 2'3'-cGAMP, as well as the significa

240 We show that the phosphate importer SLC20A2 is a substrate of NAA60 in vitro.

241 ARID1A directly repressed the alanine importer SLC38A2 and simultaneously promoted the alanine

242 Due to impaired repression of the cystine importer Slc7a11, S47 cells show increased glutathione (

243 eted endocytic degradation of the amino acid importer Slimfast.

244 cysteine precludes product inhibition of the importer, so cystine import continues into cells that ar

245 on to known exporters, in BGCs we found many importer-specific transmembrane domains that co-occur wi

246 Major importers such as Brazil, the U.S., and India are indire

247 elements only in the subfamily of small ABC importers, suggesting a distinct mode of NBD-TMD couplin

248 bridges similar to the ATP-binding cassette importers, suggesting that ATP-binding cassette exporter

249 A: Leu, Ile, Val), and to SLC7A11, a cystine importer supplying cysteine to the synthesis of the anti

250 tochrome bo oxidase complex, as well as iron importers. Surprisingly, either iron or anti-oxidant sup

251 As in many other ABC importer systems, selectivity is applied at the level of

252 porter eamA, parallels that of the l-cystine importer tcyP.

253 ic data, we propose pGlcT2 acts as a glucose importer that can limit cytosolic glucose availability i

254 The Ctr1 protein is a high-affinity Cu(+) importer that is structurally and functionally conserved

255 OpuA from Lactococcus lactis is a type I ABC-importer that uses two substrate-binding domains (SBDs)

256 Previous studies identified amino acid importers that might function in the amino acid remobili

257 ll, the COS cell, with cDNAs for a bile acid importer, the ileal bile acid transporter (IBAT), as wel

258 n, including the principal hepatic bile acid importer, the Na(+)/taurocholate co-transporting polypep

259 y proper targeting of the mitochondrial iron importers, the mitoferrins.

260 n part to the constitutive expression of two importers: the proton-dependent NRAMP family transporter

261 tion enables the production of the ferric-BB importer to be activated by the presence of its cognate

262 nteracts with and stabilizes the MgtA Mg(2+) importer to increase intracellular Mg(2+) levels, while

263 the interaction of RECQL4 with mitochondrial importer Tom20, thereby restricting its own entry into m

264 xons and Schwann cells also express the iron importer transferrin receptor 1 (TfR1), indicating their

265 tly associated with the placental nonheme Fe importer transferrin receptor 1 (TfR1).

266 oportin and decreased expression of the iron importer transferrin receptor, likely reflecting a regul

267 ABCA4 is a eukaryotic importer transporting retinal to the cytosol to enter th

268 A second MAC1-independent importer was required for sufficient Cu to enter the cel

269 of the cost of the levy to manufacturers and importers was passed on to consumers as higher prices bu

270 this new study, PlaP, a putative putrescine importer, was characterized in P. mirabilis.

271 rstand mechanistic differences among Type II importers, we focused our studies on MolBC, for which al

272 imilar to that of ATP binding cassette (ABC) importers, whereby both systems share two homologous ATP

273 ntA), we show that Ynt is the primary nickel importer, while Nik only compensates for loss of Ynt at

274 new paradigm whereby Atp8b1 is a cardiolipin importer whose capacity to remove cardiolipin from lung

275 HG(i), especially for countries that are net importers with high GHG(i), such as many in Africa and S

276 encoding three proteins: the putative copper importer YcnJ, the copper-dependent transcriptional repr

277 Cu-binding protein YcnI and the putative Cu importer YcnJ.

278 homeostasis is complex, involving both zinc importers (Zip3) and zinc exporters (ZnT-1, ZnT-2, and Z

279 , hepatic Slc39a8 mRNA (gene encoding the Mn importer, Zip8) and Slc30a10 mRNA (gene encoding the Mn