ライフサイエンスコーパス: in the developing

1 ver, the final assembly of pyrethrins occurs in the developing achenes.

2 for Yap and its nucleocytoplasmic shuttling in the developing airway and alveolar compartments remai

3 ivity can change neurotransmitter expression in the developing and adult brain.

4 ired to shape activity-dependent connections in the developing and adult brain.

5 rotransmitter or diffusible second messenger in the developing and adult CNS.

6 ells and red fluorescent Ptf1a-lineage cells in the developing and adult mouse pancreas.

7 localization and expression patterns of TPBG in the developing and adult mouse retina using two antib

8 of the mesenchymal and epithelial cell types in the developing and mature mouse ureter.

9 Neural stem cells (NSCs) in the developing and postnatal brain have distinct posi

10 n of the STK/LATS/YAP/TAZ signalling cascade in the developing and postnatal mammalian pituitary.

11 mitigating endoplasmic reticulum (ER) stress in the developing appressorium.

12 In the developing Arabidopsis fruit, auxin minima are re

13 ugh gene identities and taxonomic affinities in the developing ash-soils are to some extent distinct

14 Spontaneous bursts of electrical activity in the developing auditory system arise within the cochl

15 mplantation, three cell lineages are present in the developing blastocyst: the trophectoderm (TE), th

16 hat branching occurs due to crossing defects in the developing braids.

17 ting the regulators of microglial activation in the developing brain across models of neuroinflammati

18 5, correlating with the time of neurogenesis in the developing brain and also at postnatal d 1.

19 Cln5 is strongly expressed in the developing brain and expression continues into ad

20 to the biological effect of smoking exposure in the developing brain and offer insight into how mater

21 both defective migration of cortical neurons in the developing brain and reduced neuronal survival.

22 Here we identify their genomic binding sites in the developing brain and test for additive effects of

23 Vascular structures in the developing brain are thought to form via angiogen

24 hypothesize that DNA methylation differences in the developing brain drive the disparate HR/LR neurob

25 ssion of a microRNA (miR-129-5p), whose role in the developing brain has not been examined, and which

26 able in determining the type of acute damage in the developing brain induced by AASD exposures, as we

27 Whether this pathway is active in the developing brain is unknown.

28 , whether BPA dysregulates ASD-related genes in the developing brain remains unclear.

29 is study highlights gene regulatory pathways in the developing brain that may contribute to acquisiti

30 release of a hormone that is needed by cells in the developing brain to survive.

31 sylmethionine: S-adenosylhomocysteine ratio) in the developing brain was reduced.

32 GABRB3 is highly expressed early in the developing brain, and its encoded beta3 subunit i

33 egulating synapse development and refinement in the developing brain, but it is unknown whether they

34 In the developing brain, uPA induces neuritogenesis and

35 hetics (GAs) causes neurobehavioral deficits in the developing brain, which has raised significant cl

36 table individual differences in connectivity in the developing brain, while facing the challenge of l

37 activating the mitotic surveillance pathway in the developing brain.

38 microbially modulated metabolites to neurons in the developing brain.

39 les accumulates millions of progenitor cells in the developing brain.

40 were a source of new blood vessel formation in the developing brain.

41 ion of genes that are not normally expressed in the developing brain.

42 ghted the immense neural plasticity apparent in the developing brain.

43 between synaptic growth and synapse function in the developing brain.

44 ining cellular health and proper functioning in the developing brain.

45 vestigated the hitherto unknown role of Cln5 in the developing brain.

46 late for investigation of emotion processing in the developing brain.

47 l proliferation, migration, and organization in the developing brain.

48 inflammation is a major component of disease in the developing brain.

49 in the development of other neural circuits in the developing brain.

50 ls complex aspects of regional cell identity in the developing brain.

51 nd is essential for neuronal differentiation in the developing brain.

52 he size of GABAergic interneuron populations in the developing brain.SIGNIFICANCE STATEMENT A pivotal

53 joining repair machinery in newborn neurons in the developing brains of both mouse and human are dem

54 Control of synapse number and function in the developing central nervous system is critical to

55 f dividing progenitor cells, a daunting task in the developing central nervous system where thousands

56 stress sensors and their downstream targets in the developing cerebellar cortex in postnatal rat.

57 tantly, conditional deletion of Brd4 in vivo in the developing cerebellum induces cerebellar morpholo

58 up genes with ciliary Wnt signalling defects in the developing cerebellum, providing new mechanistic

59 In the developing cerebellum, Sonic hedgehog (SHH) signa

60 iated with altered metabolite concentrations in the developing cerebellum.

61 s into the molecular and cell type diversity in the developing cerebellum.

62 vels of CB1R, but little is known about CB1R in the developing cerebellum.

63 e, we report on a functional role for Caspr2 in the developing cerebellum.

64 oids and their receptors are highly abundant in the developing cerebral cortex and play major roles i

65 Post-mitotic neuronal migration in the developing cerebral cortex involves Nesprin-2, wh

66 concept that microglia regulate NPC function in the developing cerebral cortex of mammalian species.

67 d organize neurons into functional ensembles in the developing cerebral cortex.

68 ormations due to impaired neuronal migration in the developing cerebral cortex.

69 to orchestrate inhibitory circuit formation in the developing cerebral cortex.

70 ttern of prospero-related homeobox 1 (PROX1) in the developing chick colon.

71 ms underlying doppel control of angiogenesis in the developing CNS, and may provide new insights abou

72 In the developing CNS, hypoxia-inducible factor alpha (H

73 For instance, in the developing cochlea, spiral ganglion neurons exten

74 nd patterning mediated through cell adhesion in the developing cochlea.

75 dentifying tip- and stalk-enriched gene sets in the developing collecting duct system.

76 a from after the s-shaped body formation and in the developing collecting ducts results in proximal t

77 A-Seq analyses of genes regulated by NEUROD2 in the developing cortex identified a number of key targ

78 The spatial patterning of gene expression in the developing cortex was thus mirrored by regional v

79 These tissues showed clear abnormalities in the developing cortex, including mislocalization of m

80 atterns instructively alters differentiation in the developing cortex, providing important in vivo in

81 suppresses excitation of downstream neurons in the developing cortical network, including nonsynapti

82 d of low-income consumers for dairy proteins in the developing countries where food control systems m

83 each year up to 200,000 child deaths, mainly in the developing countries.

84 one of main sources of calories and proteins in the developing countries.

85 s disease affecting a large number of people in the developing countries.

86 Economic water scarcity is severe in the developing countries; thus, the use of inexpensiv

87 organelles are thought to be formed de novo in the developing daughter cells.

88 AP/TAZ in vertebrates), plays distinct roles in the developing Drosophila airways.

89 This process is well-studied in the developing Drosophila brain and conserved in mamm

90 Through an RNAi screen in the developing Drosophila eye, we found that partial

91 e neuronal transcriptomes at multiple stages in the developing Drosophila visual system.

92 ell-established patterns of Wnt/Wg signaling in the developing Drosophila wing, we have defined the s

93 We find similar results in the developing Drosophila wing, where Yki becomes nuc

94 epressor Blimp1 controls cell fate decisions in the developing embryo and adult tissues.

95 re required to establish left-right identity in the developing embryo and are also implicated in a wi

96 -induced ectopic angiogenic sprouting of ECs in the developing embryo and provide pharmacological evi

97 rstanding of its spatiotemporal distribution in the developing embryo remains limited(1,2).

98 ion affects morphogen sensing and patterning in the developing embryo remains unknown.

99 In the developing embryo, melanoblasts originating from

100 In the developing embryo, p53 robustly activates importa

101 -target effects on the cardiovascular system in the developing embryo, which are independent of effec

102 (TFs) that establish morphological diversity in the developing embryo.

103 r that exhibits a complex expression pattern in the developing embryo: Znf703 mRNA is found in the ea

104 activation leads to an inflammatory response in the developing embryonic mouse brain that manifests a

105 isrupt neuronal maturation and OR expression in the developing embryonic OE.

106 How apicobasal polarity is established in the developing epidermis has remained poorly understo

107 Similarly, RNAi-mediated knockdown of Tom70 in the developing eye causes roughening and synaptic tra

108 onic tissues demonstrate FBXW11 is expressed in the developing eye, brain, mandibular processes, and

109 on function of M1BP has no domain constraint in the developing eye.

110 ernal autoantibodies that recognize proteins in the developing fetal brain.

111 esterone, affect progesterone target tissues in the developing fetal reproductive system and be metab

112 urotropic effects through the same mechanism in the developing fetus by establishing a link between t

113 l effect in utero that may be pro-arrhythmic in the developing fetus.

114 l liver are the major pro-inflammatory cells in the developing fetus.

115 V) infects human placentas, inducing defects in the developing fetus.

116 ionary digit loss through expanded apoptosis in the developing first digit.

117 l effect in utero that may be pro-arrhythmic in the developing foetus.

118 s pivotal in establishing Cux2 lineage fates in the developing forebrain.

119 nal consequences for driving gene expression in the developing forelimb.

120 Alx1 and Alx3 as well as increased apoptosis in the developing frontonasal mesenchyme.

121 CRISPR-Cas9 is active in the early embryo or in the developing germline.

122 nutrient status stimulating mtDNA biogenesis in the developing germline.

123 ce, and the expression of this gene was lost in the developing gut of mice that lacked the ICR.

124 nction as prebiotics for beneficial bacteria in the developing gut, often dominated by Bifidobacteriu

125 harmful effects and emotional dysregulation in the developing gut-brain axis.

126 nalysis, we found that the spacing of ovules in the developing gynoecium and fruits is controlled by

127 In the developing heart, the myocardium transitions from

128 kx2-5 in the regulation of cell cycle events in the developing heart, through Ccdc117's interaction w

129 easoned that MEIS1 could have a similar role in the developing heart.

130 lator for the remodeling of coronary vessels in the developing heart.

131 Here, we show that in the developing hippocampus VEGFR2 (also known as KDR

132 ould affect synapse formation and maturation in the developing hippocampus.

133 ing the spatial-temporal expression of ITIH3 in the developing human brain using the expression data

134 ur study reveals the existence of mosaic SVs in the developing human brain, likely arising from cell

135 mental and genetic factors underlying injury in the developing human brain.

136 lar germinal zones, reminiscent of processes in the developing human cerebral cortex necessary for ge

137 cell-type-specific gene expression patterns in the developing human cortex and advance our understan

138 a population of neural stem cells prevalent in the developing human cortex that contribute to its ce

139 ural progenitors (INP) similar to that found in the developing human cortex, are particularly sensiti

140 nd manipulating the role of network activity in the developing human cortex.

141 the emergence of evoked electrical activity in the developing human ENS.

142 that the role of YAP signaling is conserved in the developing human esophagus by utilizing 3D human

143 ssed with SOX9 by foregut ductal progenitors in the developing human liver and pancreas, and in pancr

144 epithelial lineages and have been described in the developing human lung; however, the mechanisms co

145 urotransmitter signaling during neurogenesis in the developing human neocortex and highlight evolutio

146 In the developing human neocortex, progenitor cells gene

147 the uvula, we demonstrated FOXF2 expression in the developing human uvula.

148 TR2A selectively activates radial glia cells in the developing human, but not mouse, neocortex, and i

149 The otx2b gene is expressed in the developing hypothalamus, and otx2bhu3625/hu3625 f

150 In the developing hypothalamus, the fat-derived hormone

151 vestigating the transcriptome of blood cells in the developing immune system.

152 verexpression in mice limits CHD7 expression in the developing inner ear, retina and brain.

153 mary, Sema signaling may play multiple roles in the developing inner ear.

154 ce gene expression and morphogenetic effects in the developing insects.

155 regions that act as fetal-specific enhancers in the developing kidney but are decommissioned in the m

156 In mice, mosaic deletion of Hnf4a in the developing kidney reduces the population of PT ce

157 arks a renal stem/progenitor cell population in the developing kidney that in adult kidney contribute

158 Little is known about lymphatics in the developing kidney, despite their established role

159 al cells identified the different cell types in the developing kidney.

160 plasticity and cellular activation occurring in the developing left and right amygdala after limited

161 1.2 activity is essential for chondrogenesis in the developing limbs.

162 on in adulthood and reprograms histone marks in the developing liver to accelerate acquisition of an

163 orter fish demonstrated nuclear ESR activity in the developing liver.

164 broaden the putative roles for immune cells in the developing lung and provide a framework for under

165 In the developing lung, localized Fgf10 expression maint

166 hat populated a niche defined by fibroblasts in the developing lung.

167 significance of Yap subcellular localization in the developing lung.

168 wers, it is about time to investigate clocks in the developing lung.

169 on via the newly recombined immune receptors in the developing lymphocytes.

170 fe, we found that decreasing DNA methylation in the developing male and female amygdala improves adul

171 signaling that generates structural changes in the developing mammalian brain.

172 division of radial glial progenitors (RGPs) in the developing mammalian cerebral cortex generates de

173 genitor cells that generate neurons and glia in the developing mammalian cerebral cortex(1-4).

174 n patterns of the transcription factor FOXP2 in the developing mammalian forebrain have been describe

175 In the developing mammalian heart, Hippo signaling regul

176 In the developing mammalian neocortex, neural stem cells

177 o the control of ductal epithelial branching in the developing mammary gland by regulating macrophage

178 es to show that Sox10 has multiple functions in the developing mammary gland.

179 erface between hedgehog1 and patched domains in the developing mesenteries and use gene knockdown, kn

180 4(S)-hydroxycholesterol (24-HC) and 24,25-EC in the developing midbrain, resulting in a specific incr

181 rrying specific inactivation of Onecut genes in the developing motor neurons, performed RNA-sequencin

182 infection produces extensive neuropathology in the developing mouse brain and spinal cord of both se

183 Acute knockdown of Myt1l in the developing mouse brain mimicked a Notch gain-of-f

184 minantly disrupt cortical neuronal migration in the developing mouse brain, strongly supporting a cau

185 is study was to identify novel roles of CTCF in the developing mouse brain.

186 /gamma-secretase is required for axon growth in the developing mouse brain.

187 in 2 as novel maturation-associated markers, in the developing mouse cardiac ventricles.

188 idative stress level progressively increases in the developing mouse cortex and regulates RGP behavio

189 ng migration and maturation of cells grafted in the developing mouse cortex.

190 ids embedded in hydrogel, and lumen pressure in the developing mouse embryo.

191 it partly overlapping patterns of expression in the developing mouse embryonic frontonasal, maxillary

192 ned the state and accessibility of chromatin in the developing mouse fetus.

193 atural substrates for GABAergic interneurons in the developing mouse forebrain, and provide valuable

194 enetically labeled POMC and NPY/AgRP neurons in the developing mouse hypothalamus to decipher the tra

195 ent to terminally differentiated fiber cells in the developing mouse lens.

196 Here, we disrupt minor spliceosome function in the developing mouse limb by ablating one of its esse

197 d to investigate the occurrence of autophagy in the developing mouse lung and its regulatory role in

198 2 windows of epithelial autophagy activation in the developing mouse lung, both resulting from AMPK a

199 mDA neurogenesis in an Lxr-dependent manner in the developing mouse midbrain in vivo and also preven

200 EC), the most potent and abundant Lxr ligand in the developing mouse midbrain, promotes mDA neurogene

201 his study, we showed that Smad7 is expressed in the developing mouse molars with a high level in the

202 uronal output of individual progenitor cells in the developing mouse neocortex using a combination of

203 normal delamination of daughter neuroblasts in the developing mouse neocortex.

204 the Cdkn1c gene is expressed at a low level in the developing mouse neocortex.

205 In the developing mouse optic tract, retinal ganglion ce

206 el using astrocyte-specific deletion of Vegf in the developing mouse retina appear to contradict this

207 high-density recordings of spiking activity in the developing mouse retina.

208 Gsx2 binds both monomer and homodimer sites in the developing mouse ventral telencephalon.

209 In the developing murine epidermis, planar and perpendic

210 ration of esophageal progenitor cells (EPCs) in the developing murine esophagus.

211 es expressed in radial glia and interneurons in the developing neocortex during mid-gestation.

212 rein Smc5 is conditionally knocked out (cKO) in the developing neocortex.

213 lls orchestrate inhibitory circuit formation in the developing neocortex.SIGNIFICANCE STATEMENT Inhib

214 astric mucosa, we conclude that loss of Tff2 in the developing neonatal small intestine enables the o

215 s metabolites such as N-acetyl-aspartic acid in the developing nervous system and N-acetyl-L-glutamin

216 re how neurons establish individual identity in the developing nervous system and why only specific n

217 Protein synthesis must be finely tuned in the developing nervous system as the final essential

218 al a role for NCCs in phagocytosis of debris in the developing nervous system before the presence of

219 Thus, Cut and cohesin regulate apoptosis in the developing nervous system by altering the chromat

220 In the developing nervous system, axons navigate through

221 The +TIP Navigator-1 (NAV1) is expressed in the developing nervous system, yet its neuronal funct

222 Restoring SIRT2 expression in the developing neuroepithelium exerted identical effe

223 For example, in the developing neuron, the protein ADAP1 (ADP-ribosyl

224 maturing brain, was significantly different in the developing opercular cortex compared to the insul

225 zebrafish, we establish that cell movements in the developing optic cup require neural crest.

226 (sex-determining region Y)-box 2 (Sox2) gene in the developing oral epithelium, including the perider

227 verse mutations affect cell types and states in the developing organism.

228 lly expressed CXCL-10, CXCR3, BDNF and ERBB4 in the developing organoids and in response to heme-indu

229 ectly stimulates Irx3 and Irx5 transcription in the developing ovary.

230 If the peri-conceptual environment in the developing oviduct is affected by gestational hyp

231 out the neural crest lineage or specifically in the developing palatal mesenchyme caused reduced pala

232 Sema3d, and Sema3e, is ectopically activated in the developing palatal mesenchyme in Osr2(-/-) embryo

233 es that exhibited Foxf2-dependent expression in the developing palatal mesenchyme, 88 contained or we

234 these putative target loci, including Fgf18, in the developing palatal tissues was verified by ChIP-p

235 uggest that differential activation of Ptf1a in the developing pancreas may correlate with this beta-

236 nd exocrine fates of multipotent progenitors in the developing pancreas, and loss of Dll1 leads to pr

237 hus uncovers that oscillating Notch activity in the developing pancreas, modulated by Jag1, is requir

238 In the developing pancreas, transient Neurog3-expressing

239 ma3d), a secreted glycoprotein, is expressed in the developing parathyroid gland in mice.

240 Here, we investigated the role of estrogen in the developing penis.

241 important for excitatory synapse development in the developing perinatal brain.

242 iated gene C4 causes aberrant circuit wiring in the developing prefrontal cortex and leads to deficit

243 roperties of retinal progenitor cells (RPCs) in the developing prenatal retina, as well as visual fun

244 e the relative contributions of the two LICs in the developing rat brain.

245 amily, strongly promotes RGC differentiation in the developing retina in vivo in rodent retinal proge

246 ceptor cells was observed by GDF-15 knockout in the developing retina in vivo.

247 Detection of ambient illumination in the developing retina prior to maturation of conventi

248 In addition, we elucidate microglia function in the developing retina, which may shed light on microg

249 te to the proper encoding of light intensity in the developing retina.

250 Thousands of enhancers are also active in the developing retinae, many having features of cell-

251 olvement in RGC axon growth and organization in the developing retinogeniculate pathway.

252 une molecule Pentraxin 3 (PTX3) is expressed in the developing rodent brain.

253 We determined that, in the developing rodent cerebellar cortex (of both sexe

254 However, Nkx2-5 is expressed in the developing SAN junction, suggesting a role for Nk

255 eta may catalyze the removal of HFAs from PC in the developing seeds synthesizing these unusual fatty

256 Regarding the role of activity in the developing somatosensory cortex, one persistent d

257 negative Drp1 impairs the branching of axons in the developing spinal cord in vivo.

258 s, and the "priming" of nociceptive circuits in the developing spinal cord, following injuries during

259 In the developing spinal cord, Onecut transcription fact

260 ndrocyte progenitor cell proliferation (OPC) in the developing SVZ, thereby altering cellular output

261 In the developing teeth, although the expression and fun

262 In the developing teeth, BSP-GFPtpz was expressed at hig

263 (DM2), is coordinately expressed with MBNL1 in the developing thymus and DM2 CCTG expansions induce

264 level of p-Smad2/3 was ectopically elevated in the developing tooth germ of Smad7 null mice, indicat

265 expression in the epithelium and mesenchyme in the developing tooth.

266 Food security remains a principal challenge in the developing tropics where communities rely heavily

267 ria with their mtDNA payload are transferred in the developing tumour, and provide functional evidenc

268 points to critical roles for the urothelium in the developing urinary tract and in the genesis of CA

269 that controls the cell cycle/VEGFR2 pathway in the developing vasculature.

270 ue Lasp from a subset of commissural neurons in the developing ventral nerve cord produces defascicul

271 eys, smooth muscle lineage and limb skeleton in the developing vertebrate embryo.

272 d suggest that alternative splicing of C-Src in the developing vertebrate nervous system evolved to r

273 ave developed a unique model to study NMDARs in the developing vertebrate nervous system.SIGNIFICANCE

274 Ventralization, a major patterning process in the developing vertebrate neural tube (central nervou

275 iscovered that RA induces Cyp26b1 expression in the developing vestibular sensory organs, which gener

276 However, in the developing visual system, RGC interactions extend

277 rior specification GRN is flexible over time in the developing wing and 2) this flexibility results f

278 of the core proteins Flamingo and Strabismus in the developing wing.

279 the leading causes of iron-deficiency anemia in the developing world and is associated with significa

280 ion-related corneal diseases that are common in the developing world and the potential for greater cr

281 Numerous deaths in children aged <5 years in the developing world occur at home.

282 more closely resembles that of human infants in the developing world than in the western world.

283 a leading cause of mortality among children in the developing world, and despite the immense progres

284 for clonally propagated root and tuber crops in the developing world, and provides an opportunity to

285 ayi represents a leading cause of disability in the developing world, causing lymphatic filariasis in

286 r (KSD) are common newborn health conditions in the developing world, contributing to substantial neo

287 Urban outdoor air pollution in the developing world, mostly due to particulate matte

288 diseases disproportionately impact patients in the developing world.

289 s of detection would find great significance in the developing world.

290 mpanied by intensive monoculture, especially in the developing world.

291 dulated to improve infant health, especially in the developing world.

292 se nucleic-acid-based modalities, especially in the developing world.

293 idity and mortality associated with diarrhea in the developing world.

294 ultimately aim to promote capacity-building in the developing world.

295 this time frame, a stiffness gradient arose in the developing Xenopus brain, and retinal ganglion ce

296 ormation of hindbrain segments (rhombomeres) in the developing zebrafish as an example, but the mecha

297 We also track migrating cells in the developing zebrafish embryo, demonstrating the ut

298 ersity of discrete epicardial subpopulations in the developing zebrafish heart.

299 ending limb (TAL) segment lineage assignment in the developing zebrafish pronephros by repressing Tfa

300 the effects of KIF3B mutant mRNA expression in the developing zebrafish retina.