ライフサイエンスコーパス: in utero

1 lignment of cardiomyocytes has been observed in utero.

2 hat mimic development of VF epithelial cells in utero.

3 ent of the nervous system in babies infected in utero.

4 generated live, albeit disorganized, tissues in utero.

5 ypically of the tissue resident memory state in utero.

6 fetuses are exposed to excess omega-6 PUFAs in utero.

7 sting the existence of microbial communities in utero.

8 mice subjected to maternal immune activation in utero.

9 mpaired cardiomyocyte proliferation and died in utero.

10 mmed by testosterone and estradiol exposures in utero.

11 tuses following removal of the thyroid gland in utero.

12 ll infants potentially exposed to Zika virus in utero.

13 t initiates a clinically silent pre-leukemia in utero.

14 disrupted by CUG(exp)-associated mechanisms in utero.

15 abnormal development of the cerebral cortex in utero.

16 erine vessels and might improve fetal growth in utero.

17 result from neurological insults that begin in utero.

18 difications associated with mercury exposure in utero.

19 determinant of fetal growth and development in utero.

20 the onset of the disease during development in utero.

21 l mass and circulating insulin concentration in utero.

22 -/- mice exhibit a myogenesis defect already in utero.

23 on-invasive whole-placenta perfusion imaging in utero.

24 D induced by exposure to valproic acid (VPA) in utero.

25 gulation of fetal nervous system development in utero.

26 ve cleft palate defects in Pax9(-/-) embryos in utero.

27 s associated with abnormal brain development in utero.

28 explained by metabolic and hormonal exposure in utero.

29 esult from inadequate cerebral oxygen supply in utero.

30 e evidence that CH mutations may be acquired in utero.

31 on and this may precipitate fatal arrhythmia in utero.

32 rodevelopmental sequelae in infants infected in utero.

33 among youths who had been exposed to alcohol in utero.

34 ibit neurogenesis in vitro or corticogenesis in utero.

35 d by pi6(-/-) fathers show reduced viability in utero.

36 ghts into the function of the human placenta in utero.

37 earliest stages of B-cell lineage commitment in utero.

38 s, 2,518 (25.9%) had been exposed to alcohol in utero.

39 is is a dynamic lifelong process that starts in utero 6 weeks postconception.

40 d a meta-analysis of the association between in utero acetaminophen exposure and risks of attention d

41 ted in immunocompromised patients and during in utero acquisition.

42 s that both postnatal feeding and conditions in utero affect lipid metabolism in infants.

43 ated behavioral effects of light to moderate in utero alcohol exposure are limited.

44 on the effects of spiral artery remodelling in utero and also indicates rapid venous drainage from t

45 Skeletal mineralization is initiated in utero and continues throughout childhood and adolesce

46 derstand how climatic conditions experienced in utero and during early childhood affect educational a

47 r health is determined by events experienced in utero and during early infancy.

48 We examined the association of air pollution in utero and during early life with pubertal development

49 Among 1,938 girls, PM10 exposure in utero and during infancy was negatively associated wi

50 Also changes in diet, with high MeHg intake in utero and during lactation, followed by increasing co

51 and children are particularly vulnerable to in utero and early-life exposures.

52 C recapitulated cellular mechanisms observed in utero and enabled experimental manipulation of cells

53 le) and 94 normally grown fetuses identified in utero and followed-up into preadolescence (8-12 years

54 o measure brain function in 32 human fetuses in utero and found that systems-level neural functional

55 because of its ability to cause microcephaly in utero and Guillain-Barre syndrome in adults.

56 Exposure to the farming environment in utero and in early childhood had little or no associa

57 ividual is exposed to different temperatures in utero and in early childhood, and we estimate flexibl

58 ay with mean temperatures above 32 degrees C in utero and in the first year after birth is associated

59 gestation, yet whether viable microbes exist in utero and interact with the intestinal immune system

60 An adverse maternal in utero and lactation environment can program offspring

61 We used microCT to determine the outcomes of in utero and lactational SSRI exposure on C57BL6 pup bon

62 use of birth defects among newborns infected in utero and morbidity and mortality in transplant and A

63 ho experienced restrictive growth conditions in utero and others exposed to maternal hyperglycaemia w

64 ing a restricted critical period that begins in utero and overlaps with the sensitive period during w

65 Of significant relevance to pediatrics, in utero and perinatal stressors may alter the lifelong

66 d metabolism is modulated by both conditions in utero and postnatal feeding in a cohort of 133 Caucas

67 The former is expressed thousands of times in utero and postnatally, whereas the latter is elicited

68 rom mice that were exposed to diesel exhaust in utero and that have subsequently undergone transverse

69 thought to be caused by two hits, the first in utero and the second in childhood in response to infe

70 f gestation) who had been exposed to opioids in utero and who had signs of the neonatal abstinence sy

71 uences of transmaternal exposure to H pylori in utero and/or during lactation for susceptibility to v

72 Adverse in-utero and perinatal conditions might contribute to an

73 We aimed to investigate in-utero and perinatal exposures associated with suicide

74 es that investigated the association between in-utero and perinatal factors and suicide, suicide atte

75 The most vulnerable exposure period may be in utero, and future regulations should also aim to redu

76 may be vulnerable to disruption by nicotine in utero, and suggest new mechanisms for pediatric disor

77 Such in utero androgen excess recreated the dyslipidaemia and

78 These human genetics studies and recent in utero animal modeling work suggest that precise contr

79 elative risks (RRs) for associations between in utero antiretroviral exposure and microcephaly status

80 We aimed to evaluate whether individual in utero antiretroviral exposures were associated with i

81 lood flow in adult hearts, however, existing in utero approaches are compromised by spontaneous fetal

82 amma-T) isoform levels in early childhood or in utero are associated with childhood lung function.

83 These mice express KrasG12D in utero, are born at normal Mendelian ratios, develop h

84 e explanation is that risk of obesity begins in utero as a result of developmental plasticity during

85 nant females against fetal ZIKV transmission in utero as well as in infants against ZIKV infection af

86 late (future cortex) is readily identifiable in utero at MRI.

87 In-utero BOLD MRI time series were acquired at 29 to 34

88 Here, we demonstrated that in utero BPA exposure also disrupted the transcriptome p

89 The fundamental features of in-utero brain development, including local synaptic E-I

90 fects in a calcium-dependent manner and that in utero Ca(v)1.2 gain-and-loss of function reciprocally

91 We showed folinic acid supplementation in utero can partially rescue the cleft lip phenotype.

92 ng those that occur during fetal development in utero, can cause epigenetic effects that modulate DNA

93 reatment of anticipated postnatal disease by in utero cell transplantation (IUCT).

94 In this study, we addressed the role of in utero choline supply for the development and later fu

95 lation data and thereby generate a score for in utero cigarette smoke exposure.

96 evealed a significantly higher prevalence of in utero CMV infection in ALL cases (n = 268) than healt

97 hanges in structure and function produced by in utero conditions can have long-term implications.

98 dicate that IDLVs may be efficient tools for in utero cord transduction in therapeutic strategies suc

99 osphingosine-1-phosphate) and results in the in utero death of ~50% of embryos at E12.5 whereas Acer2

100 ial cell deletion of Sec22b also resulted in in utero death.

101 We generated gliomas in WT mice via in utero deletion of key tumor suppressor genes and seri

102 urine model of the disease and suggestive of in utero depletion of this neuronal population as a cons

103 The placenta is essential for normal in utero development in mammals.

104 However, the in utero development of mammals limits our understanding

105 ution of (44)Ca/(42)Ca ratios in enamel from in utero development to first months of postnatal develo

106 r a process that largely occurs during human in utero development, and is therefore poorly accessible

107 lcium, sodium, and potassium) contributes to in utero developmental processes such as neural prolifer

108 In utero dietary intervention could be implemented as pr

109 In utero disruption resulted in more pronounced social a

110 Low availability of choline in utero disrupts development and function of the retina

111 diated inhibition of Dickkopf (DKK) activity in utero during palatal shelf morphogenesis partly rescu

112 sulfur dioxide and nitrogen dioxide exposure in utero, during infancy, and in childhood were negative

113 Peak thymic output occurs in utero, during infancy, and in early childhood, dimini

114 ic precursors of these cortical neurons were in utero electroporated with CBSH3- or CBSH3+ DNAs, migr

115 NQ2(I205V) into L2/3 pyramidal neurons using in utero electroporation also results in a hyperexcitabl

116 expressed in mouse embryos of either sex via in utero electroporation at low, intermediate, and high

117 Mouse in utero electroporation experiments reveal that Nckap1

118 hysical analysis, cell migration assays, and in utero electroporation experiments to probe the import

119 To address these issues, we performed in utero electroporation into the developing rat brain t

120 Moreover, using an in utero electroporation model, we observed that neurons

121 ng Nex-Cre-mediated recombination as well as in utero electroporation of a Cre-expression construct i

122 Lmnb1 silencing in mouse embryonic brain by in utero electroporation of a specific Lmnb1 sh-RNA resu

123 In utero electroporation of L1-80 into reeler embryos no

124 Here, we used in utero electroporation of shRNAs or LIC functional dom

125 CAPZB2 expressed by in utero electroporation prevented normal elongation of

126 ant alleles in developing mouse brains using in utero electroporation resulted in abnormal pyramidal

127 DGCR2 mutation in mouse corticogenesis using in utero electroporation targeted to projection neurons.

128 We combined the imaging window with in utero electroporation to label and track cell divisio

129 Using in utero electroporation to manipulate the sumoylation s

130 Here, we use in utero electroporation to restrict the DISC1 knock-dow

131 Using in utero electroporation, we show here that the IGF-1R i

132 Furthermore, through in utero electroporation, we show that downregulation of

133 In utero, electroporation demonstrates that activation o

134 preterm delivery and alleviated fetal demise in utero elicited after cPAF administered by i.p. or int

135 or implantation and placentation, including "in utero embryonic development," "placenta development,"

136 al age and can be affected by changes to the in utero environment and maternal immunity.

137 Premature birth terminates the hypoxic in utero environment and supply of maternal hormones.

138 These favorable changes in the in utero environment normalized postnatal growth, decrea

139 y of metabolites as biomarkers/indicators of in utero environmental exposure.

140 eivable that the NCOR complex may bridge the in utero environmental risk factors of ASD with epigenet

141 ind that animals exposed to low choline diet in utero exhibit a significant degree of intraindividual

142 Offspring exposed to UFPs in utero exhibited reduced inflammatory response to HDM.

143 In utero experience, such as maternal speech in humans,

144 We show that DNA damage caused by in utero exposure can reappear postnatally after an immu

145 However, studies of in utero exposure had important limitations.

146 OHAD) hypothesis, which holds that stressful in utero exposure manifests as disease in adulthood.

147 ased data about perinatal outcomes following in utero exposure remain limited.

148 In utero exposure to aircraft-origin UFPs was positively

149 In utero exposure to allergic inflammation increased mas

150 propose a new model to study the effects of in utero exposure to anti-Caspr2 antibody.

151 In utero exposure to antibiotics and risk of congenital

152 ergic asthma (AA) is inexplicably rising and in utero exposure to cigarette smoke increases the risk

153 In utero exposure to diesel exhaust air pollution has be

154 in neonatal cultured cardiac myocytes after in utero exposure to diesel exhaust and found that the p

155 In utero exposure to diesel exhaust particulates is asso

156 ylation within cardiomyocytes as a result of in utero exposure to diesel exhaust.

157 Emerging animal data suggest that in utero exposure to dietary refined carbohydrates may p

158 In adjusted models, in utero exposure to efavirenz (4.7% exposed) was associ

159 In utero exposure to glucocorticoids (iuGC) triggers pro

160 We established a murine model of in utero exposure to human recombinant NR1 and isotype-m

161 In utero exposure to malaria also impacts the activation

162 Some data suggest that in utero exposure to malaria may induce immunologic tole

163 ts of the fetal immune system are altered by in utero exposure to malaria, discuss factors that may t

164 The current study examined the impact of in utero exposure to maternal tobacco smoke on the cord

165 so begin to address the relationship between in utero exposure to smoking and the heightened risks fo

166 are found in juvenile macaque tissues after in utero exposure to two doses of gadoteridol, indicatin

167 and minor, but the evidence about harms from in utero exposure was inconclusive.

168 ivity was largely unaltered in children with in utero exposure.

169 Cs is hampered by the lack of data on direct in utero exposure.

170 ffspring asthma development, suggesting that in utero exposures can influence offspring asthma.

171 al UFP dispersion model approach to estimate in utero exposures.

172 eterm birth (PTB) is commonly accompanied by in utero fetal inflammation, and existing tocolytic drug

173 outcome was a composite of perinatal death (in-utero fetal death after randomisation or known neonat

174 in pools, within the developing mouse brain in utero, followed by single-cell RNA-sequencing of pert

175 insertions and/or deletions, similarly occur in utero for TCR but not BCR, suggesting earlier mucosal

176 Here, we show in utero gain-of-function of the psychiatric risk gene t

177 In utero gene therapy (IUGT) to the fetal hematopoietic

178 the context of the embryonic brain using an in utero gene transfer tool.

179 During sensitive periods in utero, gonadal steroids help organize biological sex

180 SM(39:1) was around half as abundant in in utero groups among breastfed infants only.

181 ing growth rates post-birth when compared to in-utero growth and therefore was more representative of

182 dinal characterization of early brain growth in-utero has been limited by a number of challenges in f

183 ts of female rats exposed to chronic hypoxia in utero have reduced telomere length, decreased mitocho

184 e vaccine against congenital HCMV.IMPORTANCE In utero HCMV infection can lead to miscarriage or child

185 tion is a major barrier to engraftment after in utero hematopoietic cell transplantation (IUHCT).

186 lls to determine immunological signatures of in utero HIV exposure.

187 The significantly increased risk of in utero HIV infection in neonates with cCMV indicates t

188 The risk of in utero HIV infection was 20-fold greater (odds ratio 2

189 plays a major role in the residual burden of in utero HIV transmission, even in the era of ART.

190 We here describe, in a cohort of > 170 in utero HIV-infected infants from KwaZulu-Natal, South

191 re enrolled and included in analyses; 36 had in-utero HIV infection and 389 (89%) were born at term.

192 ept study in which presumptive treatment for in-utero HIV infection is initiated within 48 h of birth

193 Neonates without confirmed in-utero HIV infection received nevirapine for a median

194 ma, and allergy in childhood pointing toward in utero immune programming of the child.

195 ion by utilizing ultrasound measures of size in utero in combination with measures from delivery.

196 ed the in vivo electroporation strategy used in utero in rodents and in ovo in poultry, and apply it

197 is posits that adverse environmental factors in utero increase future risk of cardiometabolic disease

198 ction of TRBP into the mouse embryonic brain in utero increased the fraction of cells expressing Sox2

199 erozygous for Tbx1 or Fgfr1/Fgfr2 to hypoxia in utero increased the incidence and severity of heart d

200 ated with increased female susceptibility to in utero infection and enhanced functional cure potentia

201 ce of the pathogen might be attributed to an in-utero infection, acquisition from maternal flora, or

202 gramming of microglia in neonates exposed to in utero inflammation via an endogenous cerebral choline

203 Intrahepatic in utero injections of a beta globin-expressing lentivir

204 uman NC cells carrying NB relevant oncogenes in utero into gastrulating mouse embryos.

205 we show that constitutive YAP activation by in utero introduction of a non-degradable form of the YA

206 Activation of T cells in utero is associated with the fetal inflammatory respo

207 ar growth in newborns suggests that stunting in utero is unlikely to be reduced by supplemental food

208 is exquisitely sensitive to nutrient supply in utero, it is not entirely clear how nutrient-driven p

209 In mice, in utero knockdown of Neurod2 resulted in reduced number

210 In utero labeling combined with single-cell RNA-sequenci

211 Moreover, pups exposed to WIN in utero lacked constitutive CB1R-mediated suppression o

212 e to the upper SG Overexpression of Gata6 by in utero lentiviral injection is sufficient to induce ec

213 Here, we use in utero lentiviral-mediated genetic approaches in mice

214 itulate the defining features of JMML due to in utero lethality, nonhematopoietic expression, and the

215 own about the functional differences between in utero macrophage populations or how they might contri

216 as strong predictors of offspring asthma and in utero maternal-fetal immune perturbations and develop

217 odeficiency (HIV) and antiretroviral therapy in utero may have adverse effects on infant growth.

218 ing (MRI) have made possible high-resolution in utero measurements of water diffusion anisotropy in t

219 ical FA features such as delayed development in utero, microphtalmia, cellular sensitivity to mitomyc

220 as used to obtain high-speed image data from in utero mouse embryos and multi-angle, vector-flow algo

221 In utero MRI (iuMRI) detects fetal brain abnormalities m

222 w understanding to this subject using serial in utero MRI measurements of rhesus macaque fetuses, fro

223 In-utero MRI (iuMRI) has shown promise as an adjunct to

224 nicotine exposure, as opposed to maternal or in utero nicotine exposure, this study underlines the im

225 ypotheses of how a mother supports her fetus in utero, now known as "Medawar's Paradox." The mechanis

226 ease in the first three decades of life, and in utero obstruction to urine flow is a frequent cause o

227 exposure to energy and nutrient restriction in utero on their children's growth in rural Gambia.

228 dies have produced mixed findings concerning in utero OP pesticide exposure and child cognition.

229 rt of children who were exposed to vitamin A in utero or at birth.The aim of this study was to examin

230 NF-producing T cells, from babies exposed to in utero or postnatal infection, which precedes an unsta

231 variations and adverse environmental events in utero or shortly after birth can lead to abnormal bra

232 In utero overnutrition can predispose offspring to metab

233 Influence of intergenerational in utero parental energy and nutrient restriction on off

234 In utero PBO exposure caused characteristic HPE facial d

235 ny time in proximity to conception or during in utero, perinatal, or childhood time periods.

236 and delays in interneuron development during in utero period.

237 ic administered to a developing organ system in utero preemptively corrects pre-mRNA splicing to abro

238 ishing inhibitory cortical networks requires in utero proliferation, differentiation, and migration o

239 The recuperated group was generated by in utero protein restriction, followed by cross-fosterin

240 Prenatal genetic testing to diagnose DS in utero, provides the novel opportunity to initiate ear

241 ome this hurdle by employing high throughput in utero RNAi-mediated screening to identify key Rho reg

242 In utero RNAi-mediated silencing of Abi1 or Wasf2 induce

243 ing public drug coverage in Ontario, Canada, in utero serotonergic antidepressant exposure compared w

244 bjectives: To assess the long-term effect of in utero smoke exposure on lung function into adulthood,

245 changes in the F1 generation were related to in utero somatic reprogramming.

246 promised bone health, and infants exposed to in utero SSRIs have a smaller head circumference and are

247 c retinal cultures and Dlx2 gain of function in utero strongly support that DLX2 is both necessary an

248 through imaging and genomics and the various in utero surgical corrections that have been attempted t

249 These findings support the hypothesis of in utero testosterone transfer between twins, which is l

250 nelopathy genes may have a functional effect in utero that may be pro-arrhythmic in the developing fe

251 nelopathy genes may have a functional effect in utero that may be pro-arrhythmic in the developing fo

252 risk of preterm birth, the number of fetuses in utero, the gestational age when first trial treatment

253 The pros and cons of in utero therapies that can potentially restore molecula

254 Synthesized in utero, they must remain folded and soluble throughout

255 n 1967 and 1978 to show that females exposed in utero to a male co-twin have a decreased probability

256 ASD, and further demonstrated that exposure in utero to a monoclonal anti-Caspr2 antibody, derived f

257 ions) among pregnancies exposed vs unexposed in utero to biologics, thiopurines, or a combination.

258 trogen directly targets the developing penis in utero to cause hypospadias.

259 In the C57BL/6 strain, offspring exposed in utero to FA and challenged with HDM exhibited a robus

260 As fetal OLCs are exposed in utero to high levels of estrogens in maternal blood,

261 The concept that exposure in utero to maternal anti-brain antibodies contributes t

262 transfer of maternal neutralizing antibodies in utero to the fetus after maternal immunization.

263 om the onset of isolated orofacial movements in utero to the postnatal mastery of suckling at 4 month

264 this response was lost in offspring exposed in utero to UFPs.

265 l abnormalities observed in neonates exposed in utero to Zika virus (ZIKV) is needed to develop treat

266 r FEV(1) and FVC compared with those with no in utero tobacco exposure (mean difference, -6.2% predic

267 Rationale: In utero tobacco exposure is associated with reduced lun

268 In utero tobacco exposure was associated with deficits i

269 hose homozygous for the GSTM1-null genotype, in utero tobacco exposure was associated with lower FEV(

270 rm deficits in lung function associated with in utero tobacco exposure.

271 in lung function whether exposed to maternal in utero tobacco or not.

272 ments and Main Results: Exposure to maternal in utero tobacco was associated with lower FEV(1) and FV

273 ve-attenuated vaccine platforms can restrict in utero transmission of ZIKV in mice, their further dev

274 the generation of protective responses, and in utero transmission of ZIKV infection remain unclear.

275 is required to protect pregnant mice against in utero transmission than that required to protect non-

276 zing antibody alone is sufficient to prevent in utero transmission, a higher neutralizing titer is re

277 lly protects dams against ZIKV infection and in utero transmission.

278 avir group, and were considered likely to be in-utero transmissions.

279 Moreover, in utero transplantation experiments suggested that the

280 Furthermore, in utero treatment with either lithium chloride, an agon

281 Our results reveal that in utero UFP exposure at a level close to the WHO recomm

282 Using a mouse model of in utero UFP exposure, we determined early immunological

283 etwork development during connectome genesis in utero Understanding the developmental trajectory of b

284 t across three etiologically distinct models-in utero valproic acid (VPA) exposure, CNTNAP2 knockout

285 in allograft recipients and infants infected in utero Virus-neutralizing antibodies defined in vitro

286 standing the metabolic mechanisms related to in utero vitamin D exposure may therefore shed light on

287 goal was to analyze the programming role of in utero vitamin D exposure on children's metabolomics p

288 rs, and cluster membership was influenced by in utero vitamin D exposure, suggesting a prenatal progr

289 In control mice not exposed to HF diet in utero, VPA/hydralazine increased mammary tumor incide

290 In sons, exposure to smoking in utero was associated with earlier genital development

291 hen the forage productivity they experienced in utero was poor.

292 -deficient mouse models of ZIKV transmission in utero, we found that the placenta and fetus were more

293 cal and logistical) of exploring development in utero, we understand little of how the ventricular wa

294 posure to an optimal nutritional environment in utero, which cannot be alleviated by a nutritionally

295 the production of progeny exposed to malaria in utero, which is critical for understanding the postna

296 rease in cell proliferation and osteogenesis in utero, while other organ defects were not corrected.

297 in exposure of the fetus to malaria antigens in utero, while the immune system is still developing.

298 e the neurologic outcome of infants infected in utero with HCMV.

299 ence that asthma and atopy originate in part in utero, with disease risk being associated with the al

300 an allergic response of the pregnant female in utero would alter the sexual differentiation of the p