ライフサイエンスコーパス: in vitro

1 and other tissues were measured ex vivo and in vitro.

2 bon receptor (AHR) to limit ECM accumulation in vitro.

3 receptor expression on lung ILC2 in vivo and in vitro.

4 action of BT2158 and either BT2156 or BT2157 in vitro.

5 erior to that of the parent fragment peptide in vitro.

6 ls with target HLA/peptide on their surfaces in vitro.

7 s) were induced to differentiate to TM cells in vitro.

8 generates a stabilized cleavage intermediate in vitro.

9 TAMs from pro- towards anti-tumor expression in vitro.

10 affinity through its HMG DNA-binding domain in vitro.

11 ound to multiple bioactive phosphoinositides in vitro.

12 d MBLAC2 is a substrate for purified zDHHC20 in vitro.

13 ed cardiomyocytes with adult-like phenotypes in vitro.

14 utants express invariably high levels of Ena in vitro.

15 phosphate linked moiety X]-type hydrolase 3) in vitro.

16 r measuring the genome-wide activity of Cas9 in vitro.

17 nts produced Langerhans cell (LC)-like cells in vitro.

18 ating the action of IRL201104 on human cells in vitro.

19 n effectively degrade and decolorize melanin in vitro.

20 Cellular crosstalk was investigated in vitro.

21 hen evaluated for its interactions with P-gp in vitro.

22 hown to stimulate transcriptional elongation in vitro.

23 firmed for all 10 pause sites that we tested in vitro.

24 ions, 10 of which can be simultaneously used in vitro.

25 also enhanced primary human T cell function in vitro.

26 t of venom was also evaluated on macrophages in vitro.

27 r CEKs have distinct substrate specificities in vitro.

28 r controller' prevents aggregation at pH 7.5 in vitro.

29 and paracrine-mediated immune cell function in vitro.

30 e of Mn(2+) stimulates this coupled reaction in vitro.

31 e expanding the use of human neuronal models in vitro.

32 pagating the antiangiogenic effects of IMiDs in vitro.

33 on and migration of tumor cells in different in vitro 2D and 3D co-cultures.

34 0.1 muM] and inhibits tubulin polymerization in vitro; 4) had no effect upon the polymerization of th

35 leavage by recombinant DENV-2/ZIKV proteases in vitro A version of this sensor containing the flavivi

36 ese combined models were parameterised using in vitro activities of carbonic anhydrase (CA), pyruvate

37 Cold-grown Miscanthus plants increased in vitro activities of RuBisCO and PPDK but decreased PE

38 In vitro activity measurements and functional mutagenesi

39 displayed over threefold and 10-fold higher in vitro activity than ivermectin against hepatic and bl

40 ted PD-1 following P. falciparum stimulation in vitro Additionally, functional in vitro studies revea

41 uced higher amounts of leukotriene B4 (LTB4) in vitro after activation with zymosan or immune complex

42 l-4-isoxazolepropionic acid (AMPA) receptors in vitro after exposure to patients' CSF antibodies or S

43 membranes to study lipid-lipid interactions in vitro, alongside optical microscopy techniques aimed

44 cation of microsatellites in order to reduce in vitro amplification noise.

45 lines in adherent and nonadherent conditions in vitro and analyzed changes in mRNA and protein levels

46 interface residues blocks filament formation in vitro and autophagosome closure and HIV-1 release in

47 effective mast cell degranulation inhibitor in vitro and can be delivered topically for prolonged pe

48 This article discloses the in vitro and cellular activity profiles of GSK789, a pot

49 also replaced E. coli BioC both in vivo and in vitro and complemented biotin-independent growth of t

50 anti-donor type T cell response was detected in vitro and conventional immunosuppressants targeting T

51 poly(ADP-ribose) polymerase inhibitors both in vitro and ex vivo These findings might pave a way for

52 compound with partial FXR agonistic activity in vitro and FXR-dependent gene modulation in vivo.

53 Studies in vitro and in affected joints demonstrated that A2AR l

54 Moreover, we demonstrate in vitro and in cells that Fes1 oxidation is reversible

55 al integrity following oxidative stress both in vitro and in cells to elucidate details of the intera

56 ctively captured known CS-E-binding proteins in vitro and in cells.

57 re-existing CMV immunity against tumor cells in vitro and in mouse cancer models.

58 In a hypothesis-driven in vitro and in silico approach, we turn to early and lo

59 and composition, as the substrates of PfCRT in vitro and in situ, and show that PfCRT does not media

60 mammary carcinoma cells to radiation therapy in vitro and in vivo (in immunocompetent syngeneic hosts

61 MIB1 physically interacts with WRN in vitro and in vivo and induces ubiquitination and degr

62 Both in vitro and in vivo assays showed that TubZIP28 bound t

63 The peptide profile generated after in vitro and in vivo digestion showed clear similarities

64 mathematical model was proposed to link the in vitro and in vivo evolution of prostate cancer.

65 o many types of applications, including both in vitro and in vivo experiments.

66 In vitro and in vivo growth responses of Abi-/Enza-resis

67 This effect is associated with a series of in vitro and in vivo immune abnormalities consistent wit

68 aggregation, and inhibits its toxicity both in vitro and in vivo In this study, we investigate wheth

69 rimary LSCs from MLL-rearranged AML patients in vitro and in vivo in xenograft mice.

70 Several in vitro and in vivo mechanisms involved in PDAC metasta

71 Finally, in vitro and in vivo microdosimetry was modeled from exp

72 quantities of the mini-protein and permitted in vitro and in vivo SAR exploration of this modality.

73 ented along with its application to multiple in vitro and in vivo studies across species.

74 In vitro and in vivo studies demonstrated that 20 restor

75 g novel anticancer target based on extensive in vitro and in vivo studies with archazolids, complex p

76 ncoded VP3 antagonizes RNase L activity both in vitro and in vivo These studies highlight an ever-evo

77 holesterol efflux mediated by apoA-I or HDL3 in vitro and in vivo Using LC-MS/MS analysis, we analyze

78 has been reported across cancer types, both in vitro and in vivo, and implicated in multiple process

79 Designs were tested in vitro and in vivo, demonstrating alteration of the E2

80 involved in the polarization of macrophages in vitro and in vivo, including the up-regulation of int

81 1 activation by disturbed flow required Nck1 in vitro and in vivo, showing endothelial Nck1 and IRAK-

82 cells, which are collectively effective both in vitro and in vivo, thereby inducing stem cell differe

83 Both in vitro and in vivo, we find that RFX6 specifically lab

84 berghei development inside hepatocytes, both in vitro and in vivo.

85 scuss their effects on c-MYC gene expression in vitro and in vivo.

86 s from MSCs, thus suppressing bone formation in vitro and in vivo.

87 listin-resistant GNB to multiple antibiotics in vitro and in vivo.

88 din-4 labeled with IRDye 800CW, was examined in vitro and in vivo.

89 vival and promotion of aggressive phenotypes in vitro and in vivo.

90 genesis of T. gondii infection were examined in vitro and in vivo.

91 mulated monocytes drive Th17 differentiation in vitro and induce cholangiocytes to produce chemokines

92 ng pathway triggers human BTSC proliferation in vitro and influences PBG hyperplasia in vivo in the D

93 of SFMBT1 abolished ccRCC cell proliferation in vitro and inhibited orthotopic tumor growth in vivo.

94 at CERBERUS has auto-ubiquitination activity in vitro and is localized within distinct motile puncta

95 sheds light on human airway differentiation in vitro and provides a single-cell atlas of the develop

96 reparing islets that enhances islet function in vitro and reduces immunogenicity.

97 ole of PrimPol in tenofovir-induced toxicity in vitro and show that tenofovir-diphosphate incorporati

98 w human IgM affects C. neoformans morphology in vitro and suggest that the hypothesis that human immu

99 upon hydrolysis is fluorescent) was compared in vitro and their vaccine efficacy (antigen-specific an

100 in reduced tumor cell migration and invasion in vitro and tumor growth and metastasis in vivo.

101 P) are recruited by the CPSF30-hFip1 complex in vitro, and both hFip1 binding sites in CPSF30 can sup

102 ne platform for advanced testing of implants in vitro, and demonstrate the scientific validity and pr

103 eus, exhibits decreased rates of acetylation in vitro, and is effective at lowering bacterial load in

104 ls or PV(+) cells can trigger SWRs, as shown in vitro, and suggests that PV(+) cell-mediated short-te

105 rhangs and directly blocks MRE11 degradation in vitro, and the DNA-binding ability of CST is required

106 Newly synthesized compounds were examined in vitro, and their mechanism of action was preliminaril

107 Auranofin's in vitro antibacterial activity was stable in the presen

108 against E. coli, S. aureus, and S. typhi in in vitro antimicrobial tests, followed closely by AA/PA-

109 the dynamics of microtubule/motor assemblies in vitro as well as in diverse intracellular structures

110 uding cellular invasion and colony formation in vitro, as well as tumor growth and metastasis in vivo

111 Here, we developed a novel in vitro assay to characterize the length and position o

112 In vitro assays indicated that Sl-LIP8 can cleave 18:2 a

113 ly been hampered by inappropriately tailored in vitro assays of drug response.

114 In vitro assays with human enzymes show that PCNA and it

115 ty and its suppression by PI3K activation in in vitro assays with SH-SY5Y human neuroblastoma cell cu

116 on protein exhibited high enzyme activity in in vitro assays.

117 erve such structures by negative stain EM of in vitro assembly reactions.

118 ve examined the priming of naive CD4 T cells in vitro at fever temperatures, and we report notable fe

119 kale and spinach were subjected to digestion in vitro at pH 2.0 and pH 7.5 and analysed using SEC-ICP

120 hibits aragonite precipitation from seawater in vitro, at the pH, saturation state and approximate as

121 In vitro bactericidal efficacy studies were carried out

122 ity of this EVG nanoformulation to cross the in vitro BBB model and suppress the HIV-1 in macrophage

123 Here, through the use of in vitro biochemical assays, we demonstrate that the ami

124 in their consensus binding sequence, both in in vitro biochemical binding assays and in vivo studies

125 xperiments with CSLD-CESA chimeric proteins, in vitro biochemical reconstitution, and supporting comp

126 Recent in vitro biomechanical measurements found increased olig

127 In vitro, both tracers displayed preferential binding to

128 P130CAS mediates VEGF-A and PDGF signalling in vitro, but its cardiovascular function in vivo remain

129 Ischemia-reperfusion injury was modeled in vitro by placing human umbilical vein endothelial cel

130 This mAb neutralizes virus in vitro by preventing virus entry and spread and is pro

131 d African mosquitoes do not prevent cleavage in vitro by the Cas9/guide RNA complex.

132 stem cell-derived cardiomyocytes (hiPSC-CMs) in vitro can expand CMs modestly (<5-fold).

133 And finally, in vitro capillary sprouting assays revealed that inhibi

134 Further, single-cell analysis of in vivo and in vitro cardiomyocyte maturation trajectories identify

135 etabolite class are strong predictors of the in vitro cardiovascular effects of PCBs.

136 Yet, many current in vitro chemical assays to characterize antioxidant pot

137 four human and mouse cell lines we examined in vitro cisplatin/JH-RE-06 treatment does not increase

138 nalysis of variant proteins both in vivo and in vitro confirmed that residues in sequence motifs cons

139 epine dimers were synthesized and tested for in vitro cytotoxicity against a panel of cancer cell lin

140 HCT IRIS related to mycobacterial infection, in vitro data demonstrate the emergence of pathogen-spec

141 In vitro data showed that SC-Exos promoted neurite outgr

142 Currently no approaches for using in vitro data to anticipate such in vivo effects exist.

143 ures are put into the context of in vivo and in vitro data.

144 d interrogation of USP22-regulated functions in vitro demonstrated critical roles for USP22 in prosta

145 aracterization analysis showed that although in vitro derived effective concentrations exceeded the l

146 We show that in vitro development of tamoxifen-resistance is associat

147 In vitro, Dgkzeta deficiency results in reduced producti

148 gic) system has an array of highly sensitive in vitro diagnostic (IVD) real-time PCR assays for respi

149 testing, to food safety to the most frequent in vitro diagnostic tests, partially conducted in automa

150 have characterized the epigenome during the in vitro differentiation of human mesenchymal stem cells

151 ling perturbed UPR in myeloid precursors and in vitro differentiation of primary CD34(+) cells reveal

152 Moreover, in an in vitro digestive pepsin-trypsin treatment, 30% of quin

153 amined by single molecule force spectroscopy in vitro displays the properties of a random coil and ac

154 In vitro, DMOG had no proliferative effect on HC, but co

155 Here, we demonstrate that high-throughput in vitro DNA binding assays coupled with unbiased comput

156 In vitro DNA-binding experiments and structural predicti

157 upled with optimization of cellular potency, in vitro drug-target residence times, and in vivo PK pro

158 Before the WWTP replacement, in vitro ER (24 ng 17beta-estradiol equivalents/L)-, GR

159 Lys(63)-, and Met(1)-linked ubiquitin chains in vitro, establishing UBA(Cez) as a functional ubiquiti

160 exhaustive dialysis, mass spectrometry, and in vitro evaluation against the C165S mutant.

161 This in vitro evidence was corroborated by docking results de

162 te this model, and functionally validated by in vitro, ex vivo and in vivo techniques.

163 ype 1 (SR-B1) and CD15 on brain SHH MB cells in vitro, ex vivo, and in vivo.

164 ther synaptic plasticity rules inferred from in vitro experiments are correct in physiological condit

165 We mimic parameter uncertainty in in vitro experiments by incorporating model error that s

166 Here, in vitro experiments demonstrate that TAN1 directly bind

167 Our in vitro experiments reveal that this feature stems main

168 In vitro experiments showed that human embryonic stem ce

169 ynamics simulations were used in tandem with in vitro experiments to investigate changes in depolymer

170 During in vitro fertilisation (IVF), pharmacological activation

171 We refined ovarian stimulation and in vitro fertilization (IVF) methods established for Chi

172 In vitro findings were confirmed in vivo with an angiote

173 n inability to efficiently culture the virus in vitro for neutralization assays.

174 This paper outlines the in vitro formulation development for hydrogel-forming mi

175 developmental stages and RGCs differentiated in vitro from embryonic retinal progenitors for the effe

176 In vitro FTY720 treatment downregulated CCR7 on Y. enter

177 of S6K1 in TKI resistance was determined in in vitro gain-and-loss of function studies and confirmed

178 compared at designated timepoints throughout in vitro gastric and intestinal digestion for difference

179 e findings resulted in a profound insight in in vitro gastric molecular lipolysis mechanisms.

180 0, 20:80, 50:50 and 80:20) were subjected to in vitro gastro-intestinal digestion using a semi-dynami

181 tudy the evolution of oleuropein (OE) during in vitro gastrointestinal digestion, its bioaccessibilit

182 OBE databases, methylated TFBSs derived from in vitro high-throughput EpiSELEX-seq binding assays and

183 e demonstrate massive expansion of hiPSC-CMs in vitro (i.e., 100- to 250-fold) by glycogen synthase k

184 Characterization of defined mutations in vitro identified defects in intracellular survival an

185 In vitro IFNgamma treatment increased PD-L1 expression i

186 In vitro, IL6 treatment of MDSC-like cells activated STA

187 on of GSCs towards low concentrations of S1P in vitro In addition, inhibiting phospholipase A2 (PLA2)

188 to form paired helical filament-like fibres in vitro in the absence of additives such as heparin.

189 ity and neuronal excitability of BLA neurons in vitro in the left and right amygdala of postnatal day

190 species, or model conditions such as growth in vitro, in macrophages and in the mouse.

191 shown to be individually efficacious in RA (in vitro, in vivo, and/or in humans) and provide a stron

192 measurements made by an eyemate(R)-IO sensor in-vitro, in an artificial and controlled environment.

193 ntial to differentiate into various lineages in vitro, including osteogenic, chondrogenic, and adipog

194 sceptibility to HIV-2 infection by combining in vitro infection of tonsillar Tfh with the ex vivo stu

195 serum albumin, the potency of JMS-053 as an in vitro inhibitor of PTP4A3 and human A2780 ovarian can

196 Here, we performed in vitro integration assays, finding that for G1 and G2,

197 Generating insulin-expressing cells in vitro is no exception, with the guided series of diff

198 In vitro, knockdown of GPRC5B in human aortic SMCs resul

199 them to temozolomide (TMZ)-induced apoptosis in vitro Likewise, in in vivo human GBM xenograft experi

200 for Chinese cynomolgus macaques to generate in vitro MCM embryos.

201 When cocultured with breast cancer cells in vitro, MCs hindered activation of cMET, a master regu

202 However, in vitro measurements fail to capture the viscoelastic m

203 rst validated blood flow simulations against in vitro measurements in 3D-printed phantoms representin

204 Recent genomic studies together with in vitro measurements suggest that the nucleosome barrie

205 Motivated by the fact that in vitro membrane protein studies often require additive

206 free energy with a sensitivity comparable to in vitro methods, enabling the measurement of energy lan

207 Using in vitro mineralization assays we showed that both recom

208 on between gene signatures obtained from the in vitro model (CS vs. air) with a published data set fr

209 We established an in vitro model for the induction of these structures in

210 ction of the derivatives was evaluated in an in vitro model of cellular injury on cortical neurons.

211 As an in vitro model of haematopoietic dysfunction, the BM chi

212 We validated its effects in an in vitro model of MI/IRI in mammalian cardiac cells.

213 o variants that were predicted to be benign, in vitro modeling demonstrated that these mutations conf

214 xically effective at restraining in vivo and in vitro models expressing MET(N375S).

215 egenerative diseases, using both in vivo and in vitro models.

216 expression and functional screening using an in vitro mouse oocyte development system, we identified

217 rformed a transcriptome-wide analysis during in vitro mucociliary differentiation of human adult BSCs

218 a panel of group 1 HAs and F0045(S) exhibits in vitro neutralization activity against multiple H1N1 a

219 Partial depolymerization in vitro of nonphosphorylated smooth muscle myosin filam

220 ) -darG(Mtb) does not alter viability of Mtb in vitro or in mice.

221 T cell cytotoxicity but was not required for in vitro or in vivo leukemia clearance.

222 flammation or NRF2 activation in macrophages in vitro or in vivo.

223 mbryos were cultured to the blastocyst stage in vitro or transferred to diabetic and non-diabetic rec

224 We report here that in vitro osteoclastogenesis is greatly suppressed by sol

225 Tested against a panel of GBM cell lines in vitro, paclitaxel was found to be effective at nanomo

226 In the clinical study, 24 in vivo-in vitro pairs were eligible for further analysis, with

227 Although TMUV can be attenuated by in vitro passaging, experimental evidence supporting the

228 th measured drug combination efficacies both in vitro (Pearson's correlation = 0.93 when comparing pr

229 alytically inactive mutant in vivo (based on in vitro peptide studies) actually retains substantial H

230 irrigated microwave catheters were tested in in vitro phantom models and in 15 sheep.

231 using serum pharmacokinetics (HVTN 104) and in vitro pharmacodynamics (LANL CATNAP database).

232 tal of 19 physicochemical descriptors and 36 in vitro phenotypes revealed that chlorination status an

233 astin may be relevant targets for increasing in vitro platelet manufacturing and for managing quantit

234 macaque trophoblast stem cells (TSCs) as an in vitro platform for future assessment of primate troph

235 ed approach, starting with a high-throughput in vitro primary screen to identify inhibitors, building

236 In addition, in vitro produced intracellular-derived particles were i

237 re, fish-free feed had the highest degree of in-vitro protein hydrolysis and protein digestibility.

238 ABM300 was characterized in vitro (receptor binding, beta-arrestin2 recruitment,

239 In vitro, recombinant Crm proteins from different orthop

240 Using an in vitro reconstitution system, we describe a mechanism

241 of both patients' cells with JAK inhibitors in vitro reduced phosphorylated STAT1 to normal.

242 susceptibility (9- to 116-fold) but also on in vitro replicative fitness.

243 sed proteins: the DHX30N-NS1 RBD interaction in vitro requires the presence of a dsRNA platform that

244 hesion of CD4(+) T cells to MAdCAM-1 and the in vitro response to vedolizumab before treatment initia

245 In vitro restoration of TET expression by ascorbic acid

246 This should be considered when comparing in vitro results to in vivo systems.

247 In-vitro results demonstrated that TMNP exhibited excell

248 ass I and II HLA molecules were selected for in vitro screening against PBMC samples from a cohort of

249 of new antigen receptor (VNAR) was used for in vitro selection against recombinant human TfR1 ectodo

250 In vitro, selumetinib downregulated cellular and membran

251 factors, or AH50 less than median, impaired in vitro serum control of KP that was restored by adding

252 rkers to HIO ECs, we find that HIO ECs grown in vitro share the highest similarity with native intest

253 Iron bioavailability was determined using an in vitro simulated peptic-pancreatic digestion, followed

254 In vitro single-molecule experiments confirmed that yeas

255 ated trans-A(2)B(2) porphyrins showed decent in vitro singlet oxygen generation, which was supported

256 s of the aging hippocampus, together with an in vitro site-directed mutagenesis approach, we identify

257 We show that genetic ablation of IFT20 in vitro slows keratinocyte migration during wound heali

258 lysaccharides, phenolic compound content and in vitro starch digestion.

259 evels, implying that pDCs were refractory to in vitro stimulation after IFNalpha production in vivo.

260 Additional phenotyping and in vitro studies enabled reclassification of a KCNQ1 var

261 t review various forms of recent 3D MEAs for in vitro studies in context of their geometry, materials

262 timulation in vitro Additionally, functional in vitro studies revealed that PD-1 expression on NK cel

263 Human and experimental in vivo and in vitro studies show that the adventitia is a dynamic m

264 In vitro studies showed that rhIGF-1/BP3 treatment incre

265 Despite recent in vivo and in vitro studies supporting this function, a mechanistic

266 Preclinical studies, in vivo, and in vitro studies, in combination with mathematical model

267 In vitro study confirmed that VPS35 up-regulation by red

268 confirmed that some of these compounds were in vitro substrates of the transporter and validated the

269 of HK phosphorylation in biochemical assays in vitro suggest negative cooperativity, whereby phospho

270 ated zebularine also did not disrupt editing in vitro, suggesting that PPR65 cannot bind modified bas

271 To determine whether the in vitro susceptibility of multi-NAI-resistant AIVs is a

272 1K-N8(Q136K)) NA substitutions, which impart in vitro susceptibility only to LAN or OS, respectively.

273 d the capsule polymerase Cps1B of App1 as an in vitro synthesis tool and an alternative for capsule p

274 silico tests using known stability data, and in vitro tests using three membrane protein targets with

275 sion of Rep) display G4 unwinding activities in vitro that are significantly higher than the closely

276 ted short transient burst of competent state in vitro, the naturally developed competent state was pr

277 that active K-Ras4B dimerizes in silico and in vitro through two major interfaces: (i) beta-interfac

278 Human subcutaneous fat was cultured in vitro to promote blood vessel outgrowth prior to impl

279 r, we overexpressed BC200 by transfection of in vitro transcribed RNA and transient expression from t

280 Ensemble in vitro transcription assays indicate that PQS in the n

281 Several essential conditions for in vitro transcription by T7 RNAP were confirmed with th

282 ere, using recombinantly expressed proteins, in vitro transcription, kinetic analyses, and in vivo ce

283 NA, followed by linear amplification through in vitro transcription.

284 lators of translation in both cell-based and in vitro translation assays.

285 In vitro transport assays confirmed that some of these c

286 r substrate commonly used in high-throughput in vitro transporter inhibition assays in the early ADME

287 In vitro treatment of IEC organoids with type III IFN re

288 fold that increased cellular metabolic rates in vitro using changes in oxygen consumption rate as a r

289 Further analysis and in vitro validation revealed that metformin optimally re

290 In vitro, VE-cadDEE mutant cells displayed defects in po

291 plasma anti-RBD and anti-ECD IgG titers and in vitro VN titers.

292 8, CCL7, CCL2, and CCL3 chemotactic function in vitro We show that local as well as systemic administ

293 omal cells are exposed to hypoxic conditions in vitro, we observed a striking enhancement in HIF2alph

294 This in vivo MT phenotype was reproduced in vitro when cells were co-cultured with IL4-polarized

295 e in the ability of pDCs to produce IFNalpha in vitro, which correlated with decreased phosphorylatio

296 ugments PDGF-induced Akt and STAT3 signaling in vitro, while next generation sequencing broadly impli

297 , a classic model for studying primary cilia in vitro, with a genetic dissection of the protein-prote

298 ant micelles and was monodisperse and stable in vitro, with sufficient structural definition to suppo

299 ale rats SCI decreases opioid responsiveness in vitro within a specific subset of small-diameter noci

300 Subsequent in vitro wound-healing assays also confirmed that M2 and