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1 imulate availability of reducible substrates in vivo).
4 ity in different incubation media as well as in vivo (57-79% intact radiopeptide in blood of BALB/c m
6 mical cargoes to chloroplasts in plant cells in vivo (74.6 +/- 10.8%) and more specific tunable chang
8 ssible to determine histamine concentrations in vivo, a nasointestinal catheter with histamine-sensin
10 erentiation of cortical progenitor behaviors in vivo, a variable we have termed the expansion coeffic
12 l hyperplasia response upon carotid ligation in vivo, accompanied by decreased MMP14 activation and i
16 o oxidative stress in vitro and during aging in vivo, after which, surprisingly, they undergo G2 arre
17 estingly, however, in transplantation assays in vivo, aged HFSCs regenerated HFs when supported with
20 gel screening layer can therefore be applied in vivo, allowing for the fabrication of highly specific
21 s improve the solubility of food ingredients in vivo, along with enhancement in their bioavailability
22 een shown to detect ALS-associated pathology in vivo, although anatomical patterns of disease spread
23 endent desuccinylation activity in vitro and in vivo, among which the desuccinylation activity of SIR
25 s were highly setting specific (in vitro vs. in vivo) and compartment specific (BAL vs. blood) and lo
26 and structural heterogeneity of mural cells in vivo, and allow detailed cellular studies of the norm
27 mutations on the kinetics of TET2 catalysis in vivo, and allows time-resolved monitoring of target g
28 uppressed macrophage phagocytosis of zymosan in vivo, and antibody blockade of IFN-gamma after endoto
29 observed in animal models of BDNF deficiency in vivo, and BDNF is a common downstream intermediary fo
30 but requires lysobisphosphatidic acid (LBPA) in vivo, and can be reconstituted on supported bilayers
31 strain RN6390 promotes bacterial replication in vivo, and deletion of tspA leads to increased bacteri
32 athogen Aspergillus fumigatus forms biofilms in vivo, and during biofilm growth it has reduced suscep
33 nity GR binding in vitro, high tissue uptake in vivo, and efficient passage across the blood-brain ba
34 nt the evidence suggests durotaxis may occur in vivo, and emphasize the urgent need for in vivo demon
35 We also discuss the use of various in vitro, in vivo, and ex vivo models to elucidate the contributio
36 p, determining cis- and trans-acting lncRNAs in vivo, and generating new developments in high-through
37 orted across cancer types, both in vitro and in vivo, and implicated in multiple processes associated
40 harmacokinetic properties, displays activity in vivo, and is projected to have a low human efficaciou
41 nce for the antiviral efficacy of remdesivir in vivo, and its potential benefit in selected patients.
42 local invasion of orthotopic mammary tumors in vivo, and joint up-regulation of Cx43 and ADORA1 in b
44 n Bcl9 affect the expression of TBX3 targets in vivo, and modulation of TBX3 abundance impacts on Wnt
45 VDR knockdown (KD) on mature skeletal muscle in vivo, and myogenic regulation in vitro in C2C12 cells
46 t provide quantification of these components in vivo, and none that can isolate and quantify lipids i
47 andard-of-care antibiotics both in vitro and in vivo, and potentiated the activity of different class
48 ls in vitro, compromises anti-tumor immunity in vivo, and reduces anti-tumor efficacy in an immune-co
49 ence, improves efficacy against DCIS lesions in vivo, and requires 5-fold less CPX to achieve equival
50 tion factors to uniquely spaced DNA elements in vivo, and suggest that differential binding affinitie
52 al carbon metabolism in response to exertion in vivo, and that immune cells from trained mice are mor
53 apses are pH sensitive, actuate in vitro and in vivo, and that the electrical signaling is bidirectio
54 lutamate and GABA levels are reduced by FTLD in vivo, and that their deficit is associated with impai
56 in vitro and liquid-like nuclear condensates in vivo, and this ability is negatively regulated by Hip
58 the pharmacodynamics of cocaine are derived in vivo, and thus this work has widespread implications
59 ctive against C. albicans, both in vitro and in vivo, and to act together with antifungal drugs, sugg
61 PENDENS (LD) and SET DOMAIN GROUP 26 (SDG26) in vivo, and, together, they prevent accumulation of mon
62 be individually efficacious in RA (in vitro, in vivo, and/or in humans) and provide a strong rational
63 erlie psychosis, compared to SAL rats, using in vivo, anesthetized, electrophysiological recordings.
64 ation within tumours, suboptimal persistence in vivo, antigen escape and heterogeneity, and manufactu
65 although free antitoxin is readily degraded in vivo, antitoxin bound to toxin is protected from prot
66 ERK1/2 phosphorylation, cAMP inhibition) and in vivo (anxiety-like behaviors, cannabimimetic effects,
67 that N6-methyl-dATP is incorporated into DNA in vivo, as indicated by increased N6-methyl-dA DNA leve
68 e show here that CP33B is bound to psbA mRNA in vivo, as was shown previously for CP33C and SRRP1.
69 ATSM signal and levels of reducing molecules in vivo, as well as to evaluate the change in (64)Cu-ATS
70 a critical role in Mn-induced neurotoxicity in vivo, at least in part, by reducing astrocytic GLAST/
73 ntly used as a catalytically inactive mutant in vivo (based on in vitro peptide studies) actually ret
74 s aureus lacking this protease is attenuated in vivo, being rapidly cleared from the airway and leadi
77 ent TNBC in vitro and inhibited tumor growth in vivo, but had no effect on the proliferation of lumin
78 synaptic connectivity in cultured neurons or in vivo, but impaired NMDA-receptor-mediated responses.
80 d-interneuron precursors could differentiate in vivo, but required a prolonged time of four to seven
82 nd differentiated into ASC in response to Ag in vivo, but this was inhibited in the presence of NP-sp
83 deal technology to view biological processes in-vivo, but current microendoscopic approaches are limi
84 h in vitro, using a synthetic RNA probe, and in vivo, by quantifying endogenous levels of adenylated
90 uentially linked receptors shows selectivity in vivo, clearing three-antigen tumors while ignoring re
96 and significantly prolonged leukemia control in vivo, confirmed by a second in vivo model using the l
97 dopaminergic signaling by A(1)R-G279S(7.44) in vivo, consistent with a pathogenic role in Parkinson'
102 Strikingly, this methylation is asymmetric in vivo, detected almost exclusively on one DNA strand,
103 bypassing than monosomes, both in vitro and in vivo, due to their preventing formation of a stem-loo
105 ar macrophages) are important HIV reservoirs in vivo, especially in the central nervous system (CNS).
106 ssociated with markers of insulin resistance in vivo (euglycemic clamps and HOMA of insulin resistanc
107 Most importantly, NTZ reduces viral shedding in vivo, exhibiting its potential as a future clinical t
108 losteric activator of RodA both in vitro and in vivo, explaining how a SEDS-bPBP complex can coordina
111 Overall, this work highlights how various in-vivo 'features' such as tumor penetration, cell inter
114 analysis of apparent diffusion coefficients in vivo, for example, enables researchers to determine w
116 wn to be a promising tool, even transplanted in vivo, for transducing light stimuli to non-functionin
118 emain to be fully characterized or confirmed in vivo, giving the field a direction to grow and furthe
122 on are understood to have impacts on utility in vivo, greater granularity with respect to the impacts
126 ng and address how C4A shapes brain circuits in vivo, here, we generated a mouse model with primate-l
127 nesis, but this has not been tested directly in vivo. Here, we investigated synaptic vesicle glycopro
128 served when cells were treated with H(2)O(2) In vivo, high CCL-2 production was detected on hypoxic z
130 ong-term suppression of neuroblastoma growth in vivo, highlighting the clinical potential of CDK9/2 i
132 PT2385 as a single-agent was efficacious in vivo, however, an increase in animal survival was not
133 protein to be long-lived in striated muscles in vivo; however, more rigorous quantitative analysis of
139 nus of Set2p affect H3K36 methylation levels in vivo, illustrating the functional importance of such
140 in primary cultures of mouse glial cells and in vivo, in a mouse model of EcoHIV-associated brain inf
141 tion, superior to glass-ionomer cement alone in vivo, in a rat molar pulpotomy model after six weeks.
143 e properties and drove CNS axon regeneration in vivo, in part via secretion of a cocktail of growth f
147 ate exploration of this mechanism in studies in vivo, in wound healing or angiogenesis, in which fibr
148 eptides ex vivo (i.e., to excised tissue) or in vivo (in animals), using antagonists of opioid recept
150 tro (in bone marrow-derived macrophages) and in vivo (in mice) strategies for activating the inflamma
151 ral dynamic properties of the Reissner fiber in vivo, including embryonic fiber assembly, the continu
153 een BRG1 and ARID1A mutant endometrial cells in vivo, including loss of epithelial cell adhesion and
154 stem cell generation, both in time and space in vivo, including the ligand-receptor couple ADM-RAMP2
155 the polarization of macrophages in vitro and in vivo, including the up-regulation of interleukin 6 (I
156 tly prime tumor antigen-specific CD8 T cells in vivo, induce CD8 T cell migration to the tumor site,
157 or antigens sourced from AML cells recruited in vivo) induces local immune-cell infiltration and acti
160 ased agonism for ERK1/2 phosphorylation and, in vivo, it preferentially exerted an antidepressant-lik
161 tent decrease in the C. difficile life cycle in vivo, it was able to attenuate an overly robust infla
162 ive capability of the crypt progenitor cells in vivo, lack of crypt base columnar stem cell markers,
163 ive antifibrotic molecules both in vitro and in vivo, leading to improvement in diastolic function in
168 and cut dsDNA targets with high specificity in vivo, making it an ideal candidate for expanding the
169 ty to jointly analyze large-scale TF-binding in vivo, making possible the discovery of the potential
170 the pharmacology and toxicology in vitro and in vivo (mice and dogs), and the biodistribution and cle
171 sses activity in both visual thalamic nuclei in vivo, moderate-frequency (10 Hz) stimulation powerful
174 the role of this inhibitory phosphorylation in vivo, new phosphorylation-deficient p53-S180A knock-i
176 course of influenza A virus (IAV) infections in vivo, none have considered the impact of both diffusi
177 iated [1-(13)C]pyruvate transmembrane influx in vivo, not glycolytic flux or LDHA activity, driving a
178 cell death of multiple myeloma in vitro and in vivo, offering a therapeutic strategy for this malign
181 re reversed by dichloroacetate (in RVfib and in vivo) or siRNA targeting PDK 1 and 3 (in RVfib).
186 To test the effect of these interactions in vivo, pneumococci were preincubated with human sIgA b
187 led to achieve significant target engagement in vivo, possibly because the protein is present in cell
188 ammation, anemia, dyslipidemia, and fibrosis in vivo, potentially by binding to key metabolic regulat
189 ese Tregs display potent regulatory activity in vivo, promoting long-term skin allograft survival in
190 e responsive to porcupine (PORCN) inhibition in vivo, providing clear evidence of RNF43 impairment.
194 valuated ex vivo (IPAH-PAAF, IPAH-PASMC) and in vivo (rat chronic hypoxia-induced PH and zebrafish an
195 ng of dopamine with other circuit components in vivo, RdLight1 opens avenues for understanding many a
196 l cord stimulation system provides the first in vivo, real-time, continuous objective measure of spin
201 ed activity consistent with a threshold dose in vivo, resulting in decreased target cell burden, decr
203 ells to clonal density, to mimic lung injury in vivo, selects for rare subsets of HBECs that activate
205 st the effect of C674 oxidation on apoptosis in vivo, SERCA knock-in mice were subjected to chronic a
207 ity, in controlled laboratory conditions and in vivo, should lead to a better understanding of oral d
208 by disturbed flow required Nck1 in vitro and in vivo, showing endothelial Nck1 and IRAK-1 staining in
213 nd significantly mitigate its immunogenicity in vivo, suggesting an EK peptide cloak as a promising a
214 nalgesic effects in inflammatory pain models in vivo, suggesting potential translational applicabilit
215 gene expression, EMT, and distant metastasis in vivo, suggesting that AR may play a role in distant m
216 in the primary tumor site when reinoculated in vivo, suggesting that these cells are primed to grow
218 comparable anticoagulant effects ex vivo and in vivo (tail-bleeding assay and FeCl(3)-induced thrombo
219 t a series of experiments, both in vitro and in vivo, that reveal previously unrecognized silent pH-s
220 ve anti-inflammatory compound well tolerated in vivo, that shows efficacy in reducing disease in a mo
221 phisticated investigation of neural circuits in vivo, that would otherwise be impossible in completel
224 netics, and photopharmacology, we show that, in vivo, the centrosome's position relative to the nucle
235 binding able to sustain, for over six weeks in vivo, the localized activity of the clinically licens
237 on has been studied extensively in vitro and in vivo, the precise role of cardiac myosin light chain
238 The efficiency of GALC cross-correction in vivo, the role of the GALC substrate galactosylcerami
240 ow that if fiber formation is at equilibrium in vivo, the vast majority of cells in most tissues woul
242 are collectively effective both in vitro and in vivo, thereby inducing stem cell differentiation.
248 bing osteocytes cause the probe to fluoresce in vivo, thus allowing imaging by intravital two-photon
249 h CDKA;1- and CDKB1-containing CDK complexes in vivo, thus promoting endoreplication in developing Ar
254 ent portal glucose signaling was identified, in vivo, using a novel (68)Ga-labeled GLP-1r positron-em
256 hoblastic acute leukemia growth in vitro and in vivo, validating OGG1 as a potential anti-cancer targ
257 To test for MeCP2 binding to these motifs in vivo, we analysed human neuronal cells using ChIP-seq
258 sess the performance of the trimeric complex in vivo, we compared the ability of L(1p)M-FH and L(1p)T
259 biologic impact of this second-site mutation in vivo, we created a mouse model with the corresponding
261 iling upon acute fusion protein inactivation in vivo, we defined the core set of direct transcription
262 sed microenvironmental TGFbeta concentration in vivo, we developed a conditional transgenic mouse mod
268 le of GRK1 phosphorylation in rods and cones in vivo, we generated mutant mice in which Ser21 is subs
269 affects alpha-syn-induced neurodegeneration in vivo, we generated triple transgenic mice that overex
270 ilitate the investigation of miRNA functions in vivo, we have developed a method based on a genetical
271 ating property attributes to synaptic damage in vivo, we have generated adeno-associated viruses AAV-
273 m to modulate Pten expression in melanocytes in vivo, we highlighted the utility and advantages of ge
274 o mimic the geometry of Spire and Cappuccino in vivo, we immobilized Spire on beads and added Cappucc
277 cells and dendritic cells (DCs) in vitro and in vivo, we map T cell-DC interaction preferences, and d
280 o define the mechanism of action of beta-Pix in vivo, we optimize single-cell live-embryo imaging, ce
282 ls began to emerge to study chlamydial genes in vivo, we speculated as to what degree Tarp function c
283 on during the genesis of partial obstruction in vivo, we tested whether rapamycin could improve persi
284 ubiquitylation and deubiquitination kinetics in vivo, we used a rapid and reversible optogenetic tool
285 hich can induce non-native conformations, or in vivo, where contributions from homologous antenna com
286 ive in vitro and to maintain yeast telomeres in vivo, whereas the DeltaCEH and 1- and 2-bp alleles do
287 ranslates into meaningful metabolic benefits in vivo, wherein the dynamics of insulin signaling and r
288 low and high net oxygenation in the placenta in vivo, which are consistent with efficient delivery of
289 at is enriched at astrocyte-neuron junctions in vivo, which includes neuronal cell adhesion molecule
290 e antigen-specific CD8(+) T-cell populations in vivo, which may serve prognostic and diagnostic roles
293 ion, and migration in vitro and tumor growth in vivo, while the depletion or inhibition of PRODH bloc
294 vitro and maintain their antiviral activity in vivo, while the glycooligomers exert their inhibitory
295 feration studies in cell lines (in vitro and in vivo) with genetic manipulation, and the adverse prog
296 ction requires at least eight cell divisions in vivo, with BLIMP-1 being required for differentiation
298 localization followed by H3K36me3 deposition in vivo, with total H3K36me3 levels correlating with RNA
300 Tumour cells adapt to nutrient deprivation in vivo, yet strategies targeting the nutrient poor micr