ライフサイエンスコーパス: inaccessible

1 mobile human TEs has to date proven largely inaccessible.

2 lity definition of the target's track remain inaccessible.

3 so far been reported to be electrochemically inaccessible.

4 actual samples have remained experimentally inaccessible.

5 early post-implantation embryos are largely inaccessible.

6 d delivery technologies that were previously inaccessible.

7 ductance(13-16) have remained experimentally inaccessible.

8 mbination of scale and resolution previously inaccessible.

9 ents because optical prescriptions are often inaccessible.

10 billions of diverse molecules have remained inaccessible.

11 f polyubiquitin signals has remained largely inaccessible.

12 s that thus far have remained experimentally inaccessible.

13 se of a metamaterial is initially completely inaccessible.

14 molecular-based refrigeration-have remained inaccessible.

15 neutropenic timepoints that were previously inaccessible.

16 not deposited in a repository or were simply inaccessible.

17 cause suitable peptidoglycan substrates were inaccessible.

18 The previously inaccessible (1) H(alpha) -(13) C(alpha) dipolar couplin

19 ct route to in situ generation of previously inaccessible (1,2,5-oxadiazolyl)hydrazines.

20 igned organic cations to stabilize otherwise inaccessible 2D HOIPs with potential applications for op

21 peutically relevant proteins have unknown or inaccessible activity profiles and so cannot be targeted

22 amides, and sterically bulky amines hitherto inaccessible and a comparison of their reactivity in com

23 physiological evaluation can be cumbersome, inaccessible and costly.

24 highly accurate and precise, but relatively inaccessible and difficult to use.

25 f electronic/photonic devices with currently inaccessible and likely unimaginable functionalities.

26 or cGAS activation, are repurposed or become inaccessible, and cGAS dimerization, another prerequisit

27 it), the chromatin of which remained largely inaccessible, and retained high expression of transcript

28 s the noninterlocked equivalent of which are inaccessible, and that the mechanical bond augments the

29 tending perovskite microlasers to previously inaccessible areas, e.g., optical memory, flip-flop, and

30 noid development, and illuminates previously inaccessible aspects of human liver development.

31 ational energy transport can probe otherwise inaccessible aspects of macromolecular dynamics and inte

32 By allowing us to predict experimentally inaccessible aspects of microcompartment function, such

33 e spin configuration is higher in energy and inaccessible at ambient temperature.

34 This information is often inaccessible at depth in biological tissue, due to the h

35 Despite the inaccessible ATP site, screening identified ATP-competit

36 They also have inaccessible ATP-binding pockets, occluded by aromatic r

37 ngle-molecule experiments remains relatively inaccessible because of cost and complexity.

38 eveal important signaling phenomenon that is inaccessible because of data-limited experimental design

39 s demonstrate that the high-affinity site is inaccessible because of either a conformational change o

40 zed RBD has its RAS-binding interface mostly inaccessible because of its proximity to the membrane.

41 cans, a nutrient resource that was otherwise inaccessible because of the lack of endogenous F. nuclea

42 features of Ov population biology previously inaccessible because of the limited availability of para

43 on can be applied to synthesize a previously inaccessible BN isostere of ethylbenzene, a compound of

44 easurement of neural activation in optically inaccessible brain regions.

45 Our approach reveals otherwise inaccessible buried features and previously unresolved c

46 ort novel drug-to-target binding predictions inaccessible by 2D fingerprints and confirm three of the

47 rmation about structural changes that may be inaccessible by alternative technologies.

48 educe the fraction of genomic sites that are inaccessible by Cas9-based methods.

49 of this highly interesting porous material, inaccessible by common synthetic procedures, occurs in a

50 teps of sub-micron sized vesicles, which are inaccessible by conventional diffraction-limited optical

51 w reactivity and "unlocking" novel compounds inaccessible by conventional methods.

52 exchanging catalytic intermediates are often inaccessible by conventional NMR due its limited time re

53 , revealing atomic details in position space inaccessible by conventional scattering techniques.

54 under the SEI, these early-stage defects are inaccessible by most surface-probing techniques.

55 vated tertiary fluorides, that are typically inaccessible by nucleophilic fluorination due to competi

56 rs, congeners and analogs that are currently inaccessible by other means.

57 ansforming the polymers, especially products inaccessible by other means.

58 vides the means to generate therapeutic ADCs inaccessible by other methods that are efficient in thei

59 nal tools, including in dark genomic regions inaccessible by short-read sequencing.

60 mations not known in biology, and reactivity inaccessible by small-molecule catalysts.

61 access to a unique set of microbes that are inaccessible by standard cultivation.

62 dual components of complex mixtures that are inaccessible by traditional calorimetric and spectroscop

63 important regions within genes overlooked or inaccessible by traditional methods.

64 4yf, HFO-1234ze, and HFO-1336mzz, previously inaccessible by transition metal catalyzed difluorosilyl

65 a large number of novel RNA regulatory sites inaccessible by uniquely mapped reads.

66 The results produced are practically inaccessible by use of multiple conventional isothermal

67 ckle cell anemia mutation using a previously inaccessible CACC PAM.

68 e and transferase domains creating a solvent inaccessible cavity.

69 reatment option for patients with surgically-inaccessible CCMs or significant medical comorbidities.

70 These technologies have enabled previously inaccessible chemical transformations and have been wide

71 osome binding is not exclusively confined to inaccessible chromatin but rather correlated with local

72 s of posterior Hox TFs to bind to previously inaccessible chromatin drive patterning diversification.

73 lation, pioneer factors open tightly packed, inaccessible chromatin sites, enabling the molecular mac

74 quired for myoblast proliferation, was in an inaccessible chromatin state in the SE-Brg1 mutant, sugg

75 chromatin structure reveal accessible versus inaccessible chromatin states, while super-resolution mi

76 recognise and bind their target sequences in inaccessible chromatin to establish new transcriptional

77 aling but does not require the generation of inaccessible chromatin.

78 ound enhancers are located within regions of inaccessible chromatin.

79 al for enhancer activity that are located in inaccessible, closed chromatin regions.

80 cal DNA methylation patterns from previously inaccessible cohorts, and reveal novel survival differen

81 heterogeneous, protease-resistant, antibody-inaccessible compartments.

82 d characterize the dynamics of what had been inaccessible conformations of the DNA-protein complex.

83 importance of remotely characterizing often inaccessible, dangerous slopes to better understand land

84 The otherwise-inaccessible data revealed a range of notable packing be

85 The proportion of inaccessible data within the literature has been increas

86 and their molecular processes in previously inaccessible detail.

87 ace-bound proteins, TCRs recognize otherwise inaccessible disease-associated intracellular proteins w

88 Using SpG and SpRY, we generated previously inaccessible disease-relevant genetic variants, supporti

89 s receptor binding domains locked into their inaccessible down state, incapable of binding ACE2.

90 5-Azido-5-deoxy-d-myo-inositol was inaccessible due to an unusual beta-elimination reaction

91 However, chimpanzee tissue is inaccessible during neocortical neurogenesis when differ

92 nts provide a means of tracing the otherwise inaccessible dynamic history of migrations of cancer cel

93 cquisition of new traits and exploitation of inaccessible ecological niches [1, 2], driving evolution

94 ts of EFs and providing access to previously inaccessible EF regimes.

95 ce in oxidative gold catalysis to previously inaccessible electron-poor/electron-poor biaryls.

96 itu quantitative information about up-to-now inaccessible elemental (REE) composition patterns togeth

97 ring in difficult experimental conditions or inaccessible environments is critical for many applicati

98 nnovations, 1,998 allow growth in previously inaccessible environments, while 1,325 increase biomass

99 ighting their role as conveyors of otherwise inaccessible essential lipids to higher trophic levels.

100 xtracellular matrix renders the chondrocytes inaccessible, even to intra-articular injections.

101 The otherwise inaccessible exchange kinetics of the E-I E-II imine con

102 However, this interplay is almost always inaccessible experimentally due to the extremely fine le

103 erived preparations is to uncover previously inaccessible features of brain function that emerge from

104 ls, where relative pressures into previously inaccessible flow regions are assessed.

105 hose of interlayers and are therefore rather inaccessible for anions.

106 f the secondary structures makes RNA targets inaccessible for probe hybridization, resulting in decre

107 ll (SLOPE) method is effective on previously inaccessible forms, including circulating rings from mal

108 f leukaemogenic transformation are typically inaccessible from human patients and conventional mouse

109 t predicts accessible and, more importantly, inaccessible gene-regulatory chromatin regions solely re

110 limited to the prediction of accessible and inaccessible gene-regulatory chromatin regions, but cons

111 ables the functional discovery of previously inaccessible genes or domains with phenotypes masked by

112 type data is essential to discover otherwise inaccessible genetic associations, but is a challenge be

113 rly developmental genes into architecturally inaccessible genomic compartments.

114 Our method enables the study of previously inaccessible genomic regions and their epigenetic marks.

115 ent" regions of space centered at physically inaccessible geometries at which the calculated SF rate

116 opods can be difficult to catch due to their inaccessible habitats and cryptic coloration.

117 map the physical 3D structure of previously inaccessible habitats and demonstrates the complexity an

118 of reflectance spectra allowed materials at inaccessible heights to be properly identified by perfor

119 utility of SNOs for investigating previously inaccessible human-specific, late-stage cortical develop

120 catalyzed reaction predicts an energetically inaccessible iminium intermediate, and a lower energy co

121 owever, if affordable HCV medicines remained inaccessible in 13 countries where medicine patents are

122 to the most polar fractions of NOM which are inaccessible in conventional DI measurements.

123 elations provide unique distance restraints, inaccessible in conventional experiments without DNP, fo

124 r, both IC/VC-EC and EC-TVEC transitions are inaccessible in devices that create stretched necks by a

125 that essentially no sites are accessible or inaccessible in every cell.

126 -specific neural subtypes that are typically inaccessible in living patients, enabling the discovery

127 asymptotic behavior, which is experimentally inaccessible in most cases.

128 referentially bound to the surfaces that are inaccessible in the context of whole spike protein.

129 ved, structure-stabilizing CR3022 epitope is inaccessible in the prefusion spike, suggesting that CR3

130 /CIMS + UPLC/ESI-MS method offers previously inaccessible insight into the molecular composition and

131 Our approach provides previously inaccessible insight into the topology of eukaryotic chr

132 The previously inaccessible intermediates, trapped by ethyl propiolate,

133 cy that can be achieved with these otherwise-inaccessible intermediates.

134 e here the population genetics of previously inaccessible intestinal microbes, providing a comprehens

135 is has been recorded along the west coast of Inaccessible Island, a remote, uninhabited island in the

136 be extended to the preparation of previously inaccessible key analogues that contain deep-seated stru

137 herefore, this study uncovers the previously inaccessible kinetics and fate choices of transplanted H

138 Arctic winters are largely harsh and inaccessible leading historic data gaps during that time

139 oherent errors helps to achieve an otherwise inaccessible level of accuracy in the variational soluti

140 novel engineered disulfide bond at a solvent inaccessible location in the CH2 domain.

141 by their sporadic occurrence in obscure and inaccessible locations within these vital organs.

142 heir area of operation to various previously inaccessible locations.

143 ement of migratory populations in expansive, inaccessible marine ecosystems [6].

144 these synthetically challenging and hitherto inaccessible marine triterpenoids.

145 Both inaccessible meso-/micropore size distributions decrease

146 The realization of previously inaccessible mesoporous silica heterostructures with sep

147 plicable to a tremendous range of previously inaccessible molecular targets.

148 , but also provide a pathway to a previously inaccessible morphology.

149 Given the sheer scale and inaccessible nature of contaminated areas, phytoremediat

150 hesis to enabling colonization of previously inaccessible niches, such as feeding on xylem and phloem

151 Such details are usually inaccessible or difficult to obtain at population scales

152 However, conventional centrifuges are often inaccessible outside of standard laboratory settings, su

153 range, enabling targeting of many previously inaccessible PAMs.

154 redox potential, a previously experimentally inaccessible parameter.

155 of disease risk and initiation in otherwise inaccessible patient-specific cells.

156 features of pluripotency dynamics during an inaccessible period of human embryogenesis.

157 key structural features and yield otherwise inaccessible phases, but the extent to which crystal str

158 High-capacity phenotyping reaches hitherto inaccessible phenotypic characteristics.

159 ct recruitment of this otherwise genetically inaccessible population elicits behavioral aversion.

160 ve, highly publicized fieldwork with largely inaccessible populations resulting from institutional an

161 o replicating findings that are derived from inaccessible populations, and recent high-profile replic

162 ified by focusing on structures with methane-inaccessible pores blocked away from the main adsorption

163 Overall, a large value of inaccessible porosity occurs at pore diameters <10 nm, w

164 Multi-scale (five pore-diameter intervals) inaccessible porosity to N2 was determined using SANS an

165 deep Earth, which provide rare samples from inaccessible portions of our planet.

166 ore of histone H3 that reorients K79 from an inaccessible position, thus enabling this side chain to

167 on and carbon-heteroatom bonds at previously inaccessible positions of organic molecules.

168 nvision the technique will render previously inaccessible projects feasible.

169 Detection and identification of previously inaccessible proteins from baker's yeast Saccharomyces c

170 fferent adaptive peaks and explore otherwise-inaccessible regions of an adaptive landscape.

171 tterns of whales, particularly in remote and inaccessible regions, frequently poses logistical and ec

172 cetacean observation at sea, particularly in inaccessible regions, presenting opportunities for ongoi

173 wed us to identify cross-links in previously inaccessible regions.

174 transcription factors allows for opening of inaccessible regulatory elements and has been extensivel

175 ediator to selectively activate a previously inaccessible remote C-H bond that is one bond further aw

176 e impairment) or if the trace is present but inaccessible (retrieval impairment).

177 he photo-Hall measurement(1,2), had remained inaccessible since the original discovery of the Hall ef

178 ting electronically unique and homogeneously inaccessible single-site solid catalysts for organic syn

179 erials, systematically exploring a typically inaccessible site in the molecule enlisting a powerful f

180 nucleophilic coupling handle at a previously inaccessible site of 2,1-borazaronaphthalenes.

181 llows for selective oxidations of previously inaccessible sites on the parent carbocycles and enables

182 y promote chromatin remodeling at previously inaccessible sites.

183 by differing abilities to bind to previously inaccessible sites.

184 locations that were accessible (ice edge) or inaccessible (solid fast ice) to air-breathing predators

185 uld produce protonated CO2, an energetically inaccessible species that can be avoided by transfer of

186 into gene-regulatory dynamics at previously inaccessible stages of human forebrain development, incl

187 these elements maintain the V1V2 loop in an inaccessible state and which expose V1V2 and/or V3 epito

188 chromatin fluctuates between accessible and inaccessible states.

189 gions of the human genome, detect previously inaccessible structural variants and generate some of th

190 closely related analogue that has otherwise inaccessible structures and/or compositions.

191 analyze immune dysfunction within otherwise inaccessible target tissues.

192 adiofrequency (RF) electric-fields may reach inaccessible targets in vivo.

193 o catalyse the rapid depletion of previously inaccessible targets(2).

194 cular square complexes, including previously inaccessible targets, through the use of ball milling me

195 ug development, as it can address previously inaccessible targets.

196 patients by providing information currently inaccessible through conventional MRI techniques.

197 These linkages are previously unreported and inaccessible through de novo synthesis.

198 tion affords spirocyclic pyrrolines that are inaccessible through dipolar cycloadditions of exocyclic

199 ducts bearing vicinal stereocenters that are inaccessible through enolate alkylation, with high enant

200 NNQQNY, providing insight that was otherwise inaccessible through main chain labeling.

201 nic covalent macrocycles and cages that were inaccessible through other means.

202 to access a "forbidden glass" regime that is inaccessible through thermal history or pressure history

203 low frequency genomes which are practically inaccessible through untargeted sequencing.

204 cell type expression dynamics in previously inaccessible tissues.

205 zygous cells undergo a phenotypic transition inaccessible to "wild-type" cells with two functional EF

206 Chromatin modified by pUbT12 is inaccessible to 53BP1 but permissive to the homologous r

207 Only ECLs inaccessible to antibodies were required for the structu

208 lic acid-binding pocket is a privileged site inaccessible to antibodies, that the F2 sialic acid-bind

209 ow living creatures to perform complex tasks inaccessible to artificial rigid systems.

210 a workspace-like cognitive system can remain inaccessible to awareness.

211 nvaded into medium and small pores that were inaccessible to base brine.

212 on of silks remains elusive and subsequently inaccessible to biomimetic strategies.

213 strain manipulation with a broad tunability inaccessible to bulk or thin-film materials.

214 Here, we reveal TAD features inaccessible to cell population analysis by using super-

215 cessors promise fast algorithms for problems inaccessible to classical computers.

216 se of its intracellular localization, p53 is inaccessible to classical therapeutic monoclonal antibod

217 n achieve optoelectronic properties that are inaccessible to closed-shell compounds.

218 ms are published each year as static figures inaccessible to computational queries and analyses.

219 entirely above the Fermi level, making them inaccessible to conventional angle-resolved photoemissio

220 Muscles inaccessible to conventional clinical and electrophysiol

221 e of the interfaces makes localized activity inaccessible to conventional electrochemical techniques.

222 ating deep within the myocardium where it is inaccessible to conventional endocardial or epicardial a

223 mations can offer additional functionalities inaccessible to conventional planar electronics based on

224 t of a tissue's 3D microstructures, which is inaccessible to conventional two-dimensional histology.

225 Thus, many of these compounds are still inaccessible to date.

226 decisions and morphogenetic changes that are inaccessible to deep analysis in vivo.

227 isk for reinitiating infection within niches inaccessible to drugs, and tuning viral control of migra

228 dable systems, permitting imaging modalities inaccessible to either technique individually.

229 ithin a sulcus, the macaque FEF is virtually inaccessible to electrophysiological techniques such as

230 identify key developmental checkpoints, data inaccessible to existing approaches.

231 tion, including Gln, Arg, and Asn, which are inaccessible to existing chemical crosslinkers.

232 defined assembly models that were previously inaccessible to existing software tools, with broad appl

233 ectly probe the glass transition in a regime inaccessible to experiments.

234 on multiple markers, most cell types remain inaccessible to genetic manipulation.

235 orbing microporous materials suddenly become inaccessible to guest molecules below certain temperatur

236 ntil recently these sensory worlds have been inaccessible to human observers; now technology can allo

237 d physiologic processes that were previously inaccessible to imaging.

238 and reveals functional interactions that are inaccessible to individual studies.

239 scular thromboembolic pathologies, which are inaccessible to invasive revascularization strategies.

240 emains unknown because many of the areas are inaccessible to laminar recordings in macaques.

241 eep within sulci in macaques, rendering them inaccessible to laminar recordings.

242 ees of freedom of a quantum system, becoming inaccessible to local probes and apparently lost.

243 t healthcare providers, which may be largely inaccessible to lower socioeconomic populations.

244 ns can thrive within mammalian cells and are inaccessible to many antimicrobial agents.

245 , palliative care expertise is conspicuously inaccessible to many patients with ILD.

246 techniques may be difficult to establish or inaccessible to many researchers.

247 nefficient, unaffordable, unsustainable, and inaccessible to many.

248 f the interaction potential which was so far inaccessible to measurements.

249 ely introduce properties and phase behaviors inaccessible to micron- or nanometer-scale colloids.

250 model, it is embedded within a sulcus and is inaccessible to modern electrophysiological and imaging

251 ome of the small (sodalite) cages, otherwise inaccessible to most molecules.

252 calculation of their spectra, which has been inaccessible to most users due to the high computational

253 the ability of neutrons to probe pore spaces inaccessible to N2 and mercury.

254 cally colonized by complex consortia and are inaccessible to observation.

255 res of dynamic protein complexes that remain inaccessible to other approaches.

256 nformation in the optical near field that is inaccessible to other optical microscopy methods can be

257 eosome and thus access silent genes that are inaccessible to other transcription factors.

258 and have therefore been rendered relatively inaccessible to pediatric recipients under KAS.

259 ond is a sphingomyelin (SM)-sequestered pool inaccessible to PFO and ALOD4 but that becomes accessibl

260 The third is an essential pool also inaccessible to PFO and ALOD4 that cannot be liberated b

261 ansformations by accessing reaction pathways inaccessible to photoredox chemistry.

262 alth of information that had previously been inaccessible to researchers and clinicians.

263 f thousands of cells, with a level of detail inaccessible to similar methods.

264 Lagrangian deformation, information that is inaccessible to simple trajectory inspection or Eulerian

265 ctional DNA nanomaterials that are currently inaccessible to state-of-the-art assembly protocols.

266 make water activity measurements previously inaccessible to tensiometry.

267 in P. aeruginosa TrmD and renders the enzyme inaccessible to the cofactor S-adenosyl-l-methionine (SA

268 ypes from typical brain scans remain largely inaccessible to the examined kernel and deep learning me

269 ermitting sequential Suzuki/S(N)Ar processes inaccessible to the heterocyclic chlorides.

270 L-3 classification makes SARS-CoV-2 research inaccessible to the majority of functioning research lab

271 esource of invertebrate prey that is largely inaccessible to their competitors.

272 ibodies to targets that have been previously inaccessible to therapies delivered by injection.

273 erials and heat sources that were previously inaccessible to thermophotovoltaic energy conversion.

274 transient states, and asynchronous dynamics inaccessible to these standard techniques.

275 ive because this abiotic-biotic interface is inaccessible to traditional structural methods.

276 present-day trace of the MFT as blind faults inaccessible to trenching, and that paleoseismic studies

277 The Chinese literature has been largely inaccessible to Western academia but contains important

278 ron provides access to a range of previously inaccessible triazinyl radicals with excellent benchtop

279 ature as well as a large range of previously inaccessible Ullmann-Goldberg coupling products includin

280 ed the formation of a new gap phase that was inaccessible using only C(3)-symmetric macrocycles.

281 This approach reveals structure of memory inaccessible using traditional lineups and renders accur

282 ng halide perovskites, but has so far proven inaccessible using traditional spacer cations due to eit

283 allows the preparation of biaryls previously inaccessible via decarboxylative methods and holds other

284 gen atoms, a structural motif that is almost inaccessible via extant polymerization strategies.

285 Inaccessible via photoluminescence, these states are oft

286 ration of a larger quantity of PDX, which is inaccessible via previously reported biosynthetic approa

287 ions do not occur in nature because they are inaccessible via single-nucleotide mutations.

288 The need to resolve the numerically inaccessible viscous scale could therefore be relaxed in

289 t channel gating involves a change in solute-inaccessible volume in the CTD of ~1,900 angstrom(3) Thi

290 res active Fe(0) sites, which become largely inaccessible when shell material is abundant.

291 to three NF-kappaB sites that are otherwise inaccessible when stimulated by IL-1beta or TIGR4.

292 rategy to control infectious diseases within inaccessible wildlife populations.

293 ectrolytes (SSEs) enable high safety that is inaccessible with conventional lithium-ion batteries.

294 unclear because such small length scales are inaccessible with established fluorescence microscopy.

295 Although such information is largely inaccessible with experiments, the agreement of simulati

296 to create 2D materials that were previously inaccessible with preexisting methods.

297 rial operating conditions and was previously inaccessible with traditional metal-Cl or -hydrocarbyl p

298 quences of such repetitious behaviour remain inaccessible without comprehensive sampling strategies.

299 demanding applications previously considered inaccessible, without sacrificing the functional versati

300 However, in the nucleus, the DNA is often inaccessible, wrapped around histone proteins in nucleos