ライフサイエンスコーパス: inactive

1 ion in precursor cells, where it is normally inactive.

2 12 were defined as DPA-active and 258 as DPA-inactive.

3 ing other stereoisomers of aza-threonine are inactive.

4 t, the iLID-RTK is cytosolic, monomeric, and inactive.

5 0% uniform residual levels keep target genes inactive.

6 participate in keeping ZAR1 immune complexes inactive.

7 vs. 3.62 +/- 0.53) than when the Scuba7 was inactive.

8 othrin, pyrimethanil) were anticipated to be inactive.

9 hat become unobserved and hence are probably inactive.

10 idity Index was 5.1 +/- 1.7 and 14 (7%) were inactive.

11 a-d-glucopyranoside 2,4,6-trisphosphate, are inactive.

12 ures of mammalian dCTPase were catalytically inactive.

13 act domain arrangement that is catalytically inactive.

14 tic center, and as a result, the enzymes are inactive.

15 drogen precursors, but they are biologically inactive.

16 oxidative stress, wherein ThrRS is rendered inactive.

17 fected with mammalian reovirus, NF-kappaB is inactive.

18 (11beta-HSD1), which catalyzes conversion of inactive 11-dehydrocorticosterone to the glucocorticoid

19 igh waist circumference, 89% were physically inactive, 37% (95% confidence interval, 31%, 43%) had ph

20 space pathway, as the presence of the redox inactive 3d(10) Zn(2+) is expected to perturb the long r

21 The formation of translationally inactive 70S dimers (called 100S ribosomes) by hibernati

22 tically competent DNMT3A2, the catalytically inactive accessory subunit DNMT3B3 and a nucleosome core

23 374A) mutant strain encoding a catalytically inactive Adar with CRISPR/Cas9.

24 The compounds were inactive against the off-targets thrombin and trypsin.

25 vidual variability and ELISA specificity for inactive aggregates are key factors to consider when des

26 astim's G-CSF moiety in driving formation of inactive aggregates.

27 -matched wt mice were treated with active or inactive AID-TAT.

28 e active (nicotine) lever was similar to the inactive (air) lever and lower than the active lever tha

29 RNAs causes significant reactivation of the inactive allele in combination with removal of methyl gr

30 ynergistic effect on the reactivation of the inactive allele to levels >60% of the active allele.

31 leading to the maturation of IL-1beta, while inactive alpha-hemolysin (proHlyA) failed to do so in TH

32 One enantiomer may be active while the other inactive, alternatively one may produce side-effects and

33 nd or complexed with Ku70/80 and DNA in both inactive and activated forms at resolutions of 3.7 angst

34 M) structures of the native bovine BBSome in inactive and active states at 3.1 and 3.5 angstrom resol

35 Computational models show that the inactive and active states differ by small changes in a

36 ructures of GPCRs provide snapshots of their inactive and active states, but poorly describe the conf

37 Animals switch between inactive and active states, simultaneously impacting the

38 deficient Lys258Arg mutant was enzymatically inactive and failed to rescue growth of ACO2-deficient c

39 hancing and heterogeneous, and metabolically inactive and homogeneous.

40 (n) configurations, rendering it both redox-inactive and resistant to forming chemical bonds that en

41 We conclude that the GH-C53S dimer is inactive and responsible for the growth failure in the a

42 ructural features with both the ligand-free, inactive and the cGMP-bound, active states.

43 es, the ES conformation has been shown to be inactive and to be poorly recognized by protein binding

44 ial resistance due to potential existence of inactive and toxic enantiomers.

45 d that all the possible structures should be inactive and/or nonselective.

46 amics of the catalytic domains of GDP-bound (inactive) and GTP-bound (active) Cdc42 in solution.

47 These hybrid models were based on an inactive antagonist-bound hA(1)AR structure for the uppe

48 th GB1-GB2 heterodimer: one structure of its inactive apo state, two intermediate agonist-bound forms

49 (PDB:4ZUD) served as a template to create an inactive apo-AT1R via molecular dynamics simulation (n =

50 Molecules that are mechanochemically inactive are also studied as negative controls.

51 (v)1.4 is inactive at 3 mum, and Na(v)1.5 is inactive at 10 mum We also substituted noncoded amino ac

52 Na(v)1.3 pIC(50) = 6.4 +/- 1.0), Na(v)1.4 is inactive at 3 mum, and Na(v)1.5 is inactive at 10 mum We

53 ) = 118%, EC(50) = 0.24 muM, K(D) = 19.6 nM; inactive at autotaxin and LPA(2-6) receptors).

54 sofosbuvir, ledipasvir, and velpatasvir were inactive at concentrations up to 10 uM.

55 a single additional hydroxyl group, was also inactive at P2X7.

56 Alterations in active A and inactive B chromosomal compartments are also associated

57 d for the differentiation between active and inactive bacteria at single cell level is urgently neede

58 ed to be active, previously active, and long-inactive based on reaction-transport biogeochemical mode

59 r, we demonstrate that NF-kappaB is rendered inactive because virus infection results in reduced leve

60 ular pliers, pulling the tetramer apart into inactive beta-tryptase monomers, and may provide an alte

61 presence of insulating and electrochemically inactive binders in commercial LIB electrodes causes une

62 a novel covalent BTK inhibitor that binds an inactive BTK conformation, which affords it unprecedente

63 We show that (1) stem cells are kept inactive by the vitamin A derivative retinoic acid, whic

64 gger for lesion status switch from active to inactive can originate from an unanticipated RANKL immun

65 The Zn(II)-targeting mechanism enriches the inactive cargo in beta-cells as compared to other pancre

66 ic HBV patients occurs either spontaneous in inactive carrier (IC) patients or therapy-induced by nuc

67 The system has two parts: catalytically inactive Cas9 (dCas9) in complex with FK506-binding prot

68 through the identification of catalytically inactive Cas9.

69 d blood samples from patients with active or inactive CD and UC and controls.

70 of four differed in patients with active and inactive CD.

71 Active and inactive chromatin are spatially separated in the nucleu

72 sion, in particular, factors associated with inactive chromatin.

73 is the functional form, whereas S-OPA1 is an inactive cleavage product in mammals, and that stress-in

74 P2 undergoes a conformational change from an inactive compact state to an active extended structure t

75 ers form microscopically defined, active and inactive compartments, which likely correspond to A/B co

76 ersibly generates an unstable and metathesis inactive complex.

77 ecular weight, and more basic character than inactive compounds.

78 tterns that differentiate between active and inactive compounds.

79 eover, the NSPs that decorate NETs are in an inactive conformation and thus cannot participate in fur

80 Pyrin is held in an inactive conformation by negative regulation mechanisms

81 chiefly reflects our lack of an established inactive conformation for this protein.

82 family and found that they share a conserved inactive conformation in their activation loop that rese

83 This inactive conformation is stabilized by binding of SARM1'

84 Based on these results, the predicted inactive conformation of GSK3beta can facilitate the ide

85 edict the three-dimensional structure of the inactive conformation of GSK3beta.

86 s to the degree of stabilization of a unique inactive conformation that shares structural features wi

87 at unphosphorylated BAK1 transitions into an inactive conformation with a "cracked" activation loop a

88 at one nanobody, Nb6, binds Spike in a fully inactive conformation with its receptor binding domains

89 ause KRAS(G12C) cycles between an active and inactive conformation(4-6), and the inhibitors bind only

90 C-terminal region of mouse melanopsin in the inactive conformation, which is stabilized by the ionic

91 subunits, which serves as a signature of the inactive conformation.

92 The design of inhibitors, targeting active-inactive conformational transitions of the enzyme, can b

93 w that EIC exists as a mixture of active and inactive conformations and that functional regulation is

94 unappreciated diversity and dynamics in the inactive conformations of D(2)R.

95 By analyzing and simulating inactive conformations of the highly homologous dopamine

96 es of mammalian dCTPase have been limited to inactive constructs, which do not provide information re

97 interventions reduce PTSD symptoms more than inactive control (k = 46; n = 3,389; standardised mean d

98 .14) at posttreatment and also compared with inactive control at 6-month follow-up (k = 10; n = 738;

99 ibose (5-AR), as well as the synthesis of an inactive control derivative, 1-azidoribose (1-AR), and t

100 nces between psychological interventions and inactive control group at posttreatment for quality of l

101 bit conformational differences in active and inactive Cre protomers in crystallographic tetramers.

102 uclear export sequence abnormally accumulate inactive cRel:IkappaBalpha complexes in the nucleus foll

103 ns from patients with ulcerative colitis and inactive Crohn's disease have lower levels of CRT, which

104 ulti-molecular protein complex that converts inactive cytokine precursors into active forms of IL-1be

105 e similarly suppressed by resupplying enzyme-inactive dalphaTAT or by treatment with a low concentrat

106 PR/Cas9 activation systems based on nuclease inactive dead (d)Cas9 fused to transcriptional transacti

107 /beta-catenin signaling through formation of inactive dimers with endogenous RNF43 or ZNRF3.

108 roteins that best distinguish active LN from inactive disease are ALCAM, PF-4, properdin, and VCAM-1

109 rate for controls in bacterial component and inactive disease in metabolites.

110 een controls and CD patients with active and inactive disease, respectively.

111 cal and imaging findings showed longstanding inactive disease.

112 even in patients with apparently clinically inactive disease; acute blindness is rare during glucoco

113 The model remained inactive displaying little movement in the receptor core

114 active membrane proximal (D1) domain and an inactive distal (D2) pseudophosphatase domain.

115 ve domains, and others generate mutations in inactive domains.

116 of the replicative DNA helicase, Mcm2-7, in inactive double hexameric form around DNA.

117 2C) is either not available or exists in its inactive, drug-sensitive state.

118 hat P1 neurons, active during courtship, are inactive during copulation, whereas GABAergic mAL neuron

119 Indeed, mTORC1 is inactive during mitosis, reflecting its failure to local

120 etween 2,3,5,6TMP-TQS isomers and active and inactive enantiomers of other TQS-related compounds iden

121 s of the immune response were induced by the inactive enzyme, suggesting receptor-mediated effects.

122 Lys79 to any other amino acid resulted in an inactive enzyme.

123 n intermediate distinct from both active and inactive EPAC1 states.

124 imply by reverting a two-state active versus inactive equilibrium, but by sampling also a distinct in

125 Ten inactive fibrotic nodules, identical to end-stage de nov

126 K4/6 activity can be active after mitosis or inactive for variable time periods.

127 FAM20C wild-type (WT) and its kinase inactive form D478A proteins were generated.

128 Spores of a strain producing an inactive form of CotH, like those formed by a cotG delet

129 They bind to the active or inactive form of kinases, compete with ATP, stabilize in

130 hese results demonstrate that the glycolysis-inactive form of PKM2 plays a crucial role in the pathog

131 y, a switch to expression of a catalytically inactive form of RASA1 resulted in impaired LVV and VV d

132 decline following transient expression of an inactive form of RNMT (DeltaN-RNMT), likely due to degra

133 chromosomal position of an MCM complex, the inactive form of the DNA replicative helicase that is as

134 ion of diverse protein modules, typically in inactive form, from various cellular subsystems.

135 aments dynamically switch between active and inactive forms in response to changes in substrate and p

136 tutively active mutant Ras into functionally inactive forms may be accessible via subtle perturbation

137 eir thermodynamic properties relative to the inactive forms, including free energy, partial molar vol

138 re terminated when they are catabolized into inactive fragments by at least three different peptidase

139 by peptidases, which degrade enkephalin into inactive fragments.

140 (pMHC) ligand for T cell receptors (TCRs) is inactive from solution yet capable of activating T cells

141 The inactive GC cortisone is converted by 11beta-HSD1 to act

142 -anchored KRAS dimers in the active GTP- and inactive GDP-loaded states.

143 genes are up-regulated while the majority of inactive genes appear unchanged.

144 Only promoters of inactive genes are differentially methylated in both syn

145 -regulated but most differentially expressed inactive genes are up-regulated.

146 t phylogeny, including intron-less genes and inactive germline processed pseudogenes, with likely ove

147 nd II - initially thought to be biologically inactive - have key roles in cardiovascular physiology a

148 this suggests that LPL is condensed into its inactive helical form for storage in intracellular vesic

149 gase that ubiquitylates and helps to degrade inactive heterodimers of BTB proteins while sparing func

150 ents that spatially segregate viral DNA from inactive histones and host DNA, maximizing virus replica

151 e discuss a novel role for the enzymatically inactive homolog of CASP8, the long isoform of cellular

152 ERAD genes are enriched in the quiescent and inactive HSCs, and conditional knockout of Sel1L in hema

153 that Pif1 enables the replisome to bypass an inactive (i.e., dead) Cas9 (dCas9) R-loop barrier.

154 eptor signaling, mucin overexpression and an inactive immune microenvironment.

155 elements (TEs), however, since most TEs are inactive in humans it is unclear whether KRAB-ZFPs emerg

156 The RVP domain is inactive in isolation, in contrast to its retroviral cou

157 that cyclin-CDKs phosphorylate and render RB inactive in late G1/S, promoting entry into S phase.

158 assay using mouse striatal membranes but was inactive in membranes from GPR88 knockout mice, even at

159 ted that liver PEMT activity was essentially inactive in these infants.

160 hly vascularized, which suggests that p53 is inactive in these tumors.

161 Excipients, considered "inactive ingredients," are a major component of formulat

162 ns (ITIES) is ideally suited to detect redox-inactive ions by their ion transfer.

163 te that the active isomer of JQ1 but not its inactive isomer inhibits IL-1beta-induced RA-FLS activat

164 form of kinases, compete with ATP, stabilize inactive kinase conformations, or act through allosteric

165 is affected by heterogeneity, active versus inactive leakage, and multicomponent mass transfer, prol

166 scriminator of chronic active versus chronic inactive lesions and the only marker correlated with NfL

167 e a low RANKL/OPG ratio is often observed in inactive lesions.

168 ditioning sessions where they could press an inactive lever or an active lever that produced CS prese

169 Rats pressed more on the active versus inactive lever, and pairing CS presentation with BLA-ChR

170 uppressing the formation of Li dendrites and inactive Li and presenting higher average CE of 99.3% (2

171 years ago, the existence of a condensed and inactive LPL oligomer was proposed.

172 -2, likely by regulating the availability of inactive Mad2 at and near unattached kinetochores, gover

173 High-resolution crystal structures of inactive MCR lacking the modified amino acids were indis

174 GrlA transitions from an inactive, membrane-associated state and relocalizes to t

175 g linearly on the Lewis acidity of the redox-inactive metal with a sensitivity of 61 +/- 9 mV/pK(a) u

176 Nevertheless, mutant, inactive MGAT4D-L interacted with MGAT1 in co-immuno-pre

177 equilibrium, but by sampling also a distinct inactive "mixed" intermediate.

178 clear correlation between halogenation of an inactive model peptoid and its increased antimicrobial a

179 ) head specific, hemagglutination inhibition-inactive monoclonal antibodies (MAbs) from elderly indiv

180 ractions between BRAF and ATP that induce an inactive, monomeric conformation of BRAF(KD).

181 ly, overexpression of a NUDT16 catalytically inactive mutant blocked 53BP1 localization to double-str

182 c activity of the enzyme, as a catalytically inactive mutant form of sPLA(2)-X does not elicit the ad

183 D1(K661A) frequently used as a catalytically inactive mutant in vivo (based on in vitro peptide studi

184 Here, we show that expressing a redox-inactive mutant, NaTrxh(SS) , suppresses both S-specific

185 Exl1 inactive mutants fail to trigger such responses.

186 Using a virus containing an EndoU catalytic-inactive mutation, we detected a higher abundance of PUN

187 of this notion, integration of two helicase-inactive mutations or deletion of rqh1 generated a simil

188 e (exceptions were eyes with large active or inactive neovascular membranes); (3) reduced retinal thi

189 ased redox chemistry with functionally redox-inactive Ni centers enables oxidative transformations mo

190 here to convert some modestly active or even inactive nucleoside analogues into powerful biologically

191 ity to infer the expression state (active or inactive) of genes in the transcriptome offers unique be

192 ght on the structure of the LPL monomer, the inactive oligomer remained opaque.

193 om nonpolar amino acids and poorly active or inactive on IA derived from other amino acids tested.

194 ector Mad2 from an active conformation to an inactive one, controls checkpoint strength in Caenorhabd

195 in strong discrimination between active and inactive operanda.

196 The methodology allows inactive or "dead lithium" formation during plating and

197 When the air cleaning system was inactive, our data show that indoor SOA formation within

198 capsule-dependent fashion compared with the inactive parent peptide.

199 analyses reveal TASOR bears a catalytically-inactive PARP domain necessary for targeted H3K9me3 depo

200 atio, 7.46 [95% CI, 2.32-23.9]; P<0.001) and inactive patients (hazard ratio, 3.64 [95% CI, 1.16-11.5

201 sk of SCD was increased in highly active and inactive patients compared with active patients.

202 Inactive patients had increased risk for SCD compared wi

203 g September-October (SO), making it the most inactive period since the late 1970s.

204 Cells with inactive pgRNA transcription were enriched from 0% (HB1)

205 compared to WT mice and treatment during the inactive phase (daytime).

206 hyperphagia only in the fed state during the inactive phase of the light-dark cycle.

207 tion, reaching the nadir during the daytime (inactive phase).

208 in the active-phase mouse model than in the inactive-phase model.

209 BN and MK801 reduced neuronal death only in 'inactive-phase' neurons.

210 We report here that a catalytically inactive PhiAB6TSP (I-PhiAB6TSP) retains binding ability

211 We conclude that gp5 alleles encoding inactive polymerases, in combination with thioredoxin, c

212 Toward this goal, here, we report the first inactive precursor of the potent broad-spectrum anticanc

213 ecreted after processing of its biologically inactive precursor pro-IL-1beta in the cytosol.

214 Pol II also maintains low poising at inactive promoters after major ZGA until the blastocyst

215 nt group of proteins that are synthesized as inactive protoxins and undergo posttranslational acylati

216 y, wherein catalytic activation of otherwise inactive quinone "co-factors" by a simple Pd(2)L(4) caps

217 liculin (FLCN) complex (LFC) consists of the inactive Rag dimer, the pentameric scaffold Ragulator, a

218 atients with ESCS who had signs of active or inactive RCN in >=1 eye.

219 g(0) reduction, leading to electrochemically inactive reaction products.

220 allus KDELR2 indicated that these lead to an inactive receptor resulting in impaired KDELR2-mediated

221 ptional regulators with the capacity to bind inactive regions of chromatin and induce changes in acce

222 tions in RHBDF2 encoding the proteolytically inactive rhomboid protein, iRhom2.

223 nction depend on the seven-membrane-spanning inactive rhomboid-like proteins 1 and 2 (iRhom1/2 or Rhb

224 This is accompanied by maintaining inactive ribosomes in a hibernation state, in which they

225 ansitions between translationally active and inactive RNA states.

226 In previously active and long-inactive sediments, sulfur-cycling Deltaproteobacteria b

227 the structures of DeltaN72/DeltaC13 and ts2-inactive SERT bound to paroxetine analogues using single

228 1(+) TNBC tended to be SFK_pY527(+) (classic inactive SFK), and FOXA1(-) TNBC tended to be SFK_pY527(

229 omain of both ADADs was likely catalytically inactive, similar to known negative regulators of RNA ed

230 than in patients with active extrarenal SLE, inactive SLE, and other glomerular diseases, and correla

231 between active hexameric species and smaller inactive species that can be controlled by manipulating

232 ions and sequestration of the catalyst as an inactive species.

233 (ITIES) are often performed to detect redox-inactive species; unfortunately, due to the inherent ins

234 NAs X active coating transcript (XACT) and X inactive specific transcript (XIST)-the master regulator

235 The X inactive-specific transcript (Xist) gene is the master r

236 4 in the WRKY domain maintains RRS1-R in its inactive state and also inhibits acetylation of RRS1-R b

237 5-HT(7) receptors in their inactive state associate with G(s), as these complexes a

238 The light receptor is normally locked in an inactive state in the dark by the covalently bound inver

239 An inactive state is identified, which is stabilised by a r

240 dimer-of-dimers configuration represents an inactive state of DUOX1-DUOXA1, suggesting an oligomeriz

241 The inactive state structures of D(2)R have been described i

242 se-coupled binary complex that maintains the inactive state when agonist is not present.

243 Structures with the nSH2 (inactive state) are featured by collapsed activation loo

244 n this transmembrane interface maintains the inactive state, and its disruption leads to constitutive

245 agonist binding by stabilizing the receptor inactive state, the putative binding site of Mg(2+) on t

246 ng controversy regarding the existence of an inactive state, we explored the proton-coupled dynamics

247 ucture of the full-length human GLP-1R in an inactive state, which reveals a unique closed conformati

248 med by BBS1 and BBS7 that is occluded in the inactive state.

249 onists and receptor mutations that favor the inactive state.

250 ytic lysine (K745) in the "alphaC-helix out" inactive state.

251 the active site, thereby locking RNAP in an inactive state.

252 e than half of P-TEFb are sequestered in the inactive-state 7SK snRNP complex.

253 hows the receptor in equilibrium between two inactive states and a pre-active form, increasingly popu

254 ery individual can switch between active and inactive states and, while active, it establishes casual

255 Structural insight into inactive states highlights how they can be leveraged for

256 Individual simulations probe active or inactive states of Ras on membranes with or without anio

257 ure to rapidly shift ELF3 between active and inactive states via phase transition represents a previo

258 neages, transitions from poised to active or inactive states, and shifts in nuclease accessibility of

259 cular switches that cycle between active and inactive states, and this cycle is linked to GTP binding

260 astic in nature: toggling between active and inactive states.

261 nd CheY contains features of both active and inactive states.

262 the thermodynamic balance between active and inactive states.

263 rconverts between an active and two discrete inactive structures.

264 t of synapses, induces functional or largely inactive synapses, and generates synapses by bridging pr

265 By contrast, Int yields only inactive synapses.

266 tion of non-productively bound complexes and inactive synaptic complexes formed by Int.

267 Overall, the extremely inactive TC activity during SO of 2018 is due to the abs

268 Immunization with an inactive TcdB fragment prevents C. difficile infection (

269 itative detection of a series of model redox-inactive tetraalkylammonium cations is demonstrated, wit

270 nding to beta-catenin, C2 renders the target inactive that eventually activates proteasome system for

271 ificant proportion of HYAL2 is enzymatically inactive; thus the mechanisms through which HYAL2 dysreg

272 eal the sequential transition of DNA-PK from inactive to activated forms.

273 LukGH binds murine CD11b-I weakly and is inactive toward murine neutrophils.

274 ine myoblasts overexpressing a catalytically inactive TRIM32 mutant aberrantly accumulate alpha- and

275 In mammals, several inactive Ty3/Gypsy elements are undergoing domestication

276 ISPR, was created by linking a catalytically inactive Type VI-B Cas13 enzyme from Prevotella sp. P5-1

277 cells (n = 85) from patients with active or inactive UC or CD and controls.

278 s only activated under red light and remains inactive under white light or in darkness.

279 red split-DddA halves that are non-toxic and inactive until brought together on target DNA by adjacen

280 in D levels were compared between active and inactive uveitis groups and with local population estima

281 lower serum 25-hydroxy vitamin D levels than inactive uveitis patients and local population-based est

282 e primary analysis, remission was defined as inactive uveitis while off treatment at all visits spann

283 Galpha, as overexpression of a biochemically inactive variant protein resulted in plants indistinguis

284 Expression of a catalytically inactive variant, DIMT1-E85A, in WT and DIMT1 (+/-) cell

285 AdrA wild-type (wt) or its inactive version AdrA mutant (mut) were delivered by an

286 ea virus (icPEDV), we generated viruses with inactive versions of interferon antagonist nonstructural

287 Our report reveals that generating PEDV with inactive versions of three viral interferon antagonists,

288 During periods of sleep and inactive waking, the extracellular activity of the hippo

289 few epidemiological studies of oil wells or inactive wells exist, and none in California.

290 ntains a membrane-disrupting peptide that is inactive when VI is bound to hexon trimers.

291 T3SS effectors are thought to be inactive within the bacterium and fold into their active

292 return for follow-up after 90 days-remaining inactive without receiving suppressive medications at al

293 n-conductive and meanwhile electrochemically inactive, working as an ideal "glue" robustly bridging t

294 n multiple epigenetic pathways lock down the inactive X (Xi) state.

295 maintains histone H3K27me3 enrichment on the inactive X chromosome (Xi) in somatic cells.

296 The inactive X chromosome (Xi) is inherently susceptible to

297 igenetic maintenance and associates with the inactive X-chromosome.

298 tually exclusive determination of active and inactive Xs.

299 copy (cryo-EM) structures of translationally inactive yeast and human ribosomes.

300 n(tpyPY2Me)](2+) analog containing the redox-inactive Zn(II) ion.