ライフサイエンスコーパス: incurable

1 Multiple myeloma remains treatable but incurable.

2 gliomas eventually recur and are ultimately incurable.

3 and prolong life, the metastatic PCa remains incurable.

4 resistance to multiple treatments and become incurable.

5 Bone metastases are incurable.

6 r metastatic head and neck cancer is usually incurable.

7 en and the metastatic form of the disease is incurable.

8 Mantle-cell lymphoma is generally incurable.

9 this common B cell malignancy still remains incurable.

10 otherapy and temozolomide, it is essentially incurable.

11 and in its aggressive forms remains largely incurable.

12 the last 2 decades and which to date remains incurable.

13 prostate cancer (mCRPC), which is currently incurable.

14 r metastatic head and neck cancer is usually incurable.

15 of metastatic disease, which remains largely incurable.

16 progressively damage sight, and is currently incurable.

17 te lymphoblastic leukemia (ALL) is currently incurable.

18 ances, multiple myeloma (MM) remains largely incurable.

19 mmon, chronic skin disease that is currently incurable.

20 ary brain tumor in adults and is essentially incurable.

21 vances in cancer research it is still mostly incurable.

22 plasia in Western societies and is currently incurable.

23 and patients with bone metastases are deemed incurable.

24 atic ductal adenocarcinoma (PDAC) is usually incurable.

25 r ischemic optic neuropathy (NAION) is still incurable.

26 -1) infection is chronic and presently still incurable.

27 alent viral infections worldwide and remains incurable.

28 s a major cause of death and remains largely incurable.

29 ctory metastatic rhabdomyosarcoma is largely incurable.

30 latent reservoirs that make HCMV infections incurable.

31 ons affect vision the most and are currently incurable.

32 Although still incurable, a revolution in the treatment of MM is curren

33 (MLL-r) such as MLL-AF4 are a major cause of incurable acute lymphoblastic leukemias (ALL).

34 Asthma is a chronic, recurrent and incurable allergy-related respiratory disease characteri

35 ein aggregation for the treatment of the yet incurable alpha-synucleinopathies.

36 Metastatic colorectal cancer remains largely incurable, although in a subset of patients, survival is

37 Pseudoxanthoma elasticum is currently incurable, although some palliative treatments exist.

38 static renal cell carcinoma (mRCC) is nearly incurable and accounts for most of the mortality associa

39 tanding of the genetic underpinnings of this incurable and clinically heterogeneous disease, whole-ex

40 ic lateral sclerosis (ALS) is a progressive, incurable and fatal neurodegenerative disease.

41 Retinitis pigmentosa (RP) are a group of incurable and inherited eye conditions, and the leading

42 However, the disease remains incurable and is characterized by high rates of drug res

43 HER2-positive metastatic breast cancer is incurable and new treatments are needed.

44 ANCE African swine fever virus (ASFV) causes incurable and often lethal hemorrhagic fever in domestic

45 non-Hodgkin lymphoma (iNHL) remains largely incurable and often requires multiple lines of treatment

46 evelopmental programs drive glioblastoma, an incurable and poorly understood tumor, but their precise

47 velopmental defects from birth and follow an incurable and progressive course that often leads to pre

48 physicians communicated that the disease was incurable and that no treatment and/or palliative care w

49 Spinal cord injury is currently incurable and treatment is limited to minimising seconda

50 taneous T-cell lymphomas are rare, generally incurable, and associated with reduced quality of life.

51 ignant transformation of the mesothelium, is incurable, and can be categorized into three histologic

52 Currently OA is incurable, and its etiology largely unknown, partly due

53 Recurrence is usually incurable, and patient symptom control and quality of li

54 pite new therapies, multiple myeloma remains incurable, and patients ultimately develop drug resistan

55 reatment, mantle cell lymphoma (MCL) remains incurable, and we are still unable to identify patients

56 tion of prostate cancer to bone is a common, incurable aspect of advanced disease.

57 , the deadliest skin cancer, remains largely incurable at advanced stages.

58 rm of non-Hodgkin lymphoma that is generally incurable at more advanced stages with systemic involvem

59 Because mitochondrial diseases are incurable, attention has focused on limiting the inherit

60 Systemic lupus erythematosus (SLE) is an incurable autoimmune disease characterized by autoantibo

61 Follicular lymphoma is an incurable B cell malignancy characterized by the t(14;18

62 Follicular lymphoma (FL) is an indolent, yet incurable B cell malignancy.

63 (GBM) is a brain tumor that remains largely incurable because of its highly-infiltrative properties.

64 ses of the retina in patients with currently incurable blinding conditions.

65 on is a cause of irreversible vision loss in incurable blinding retinal diseases including retinitis

66 eversible visual dysfunction associated with incurable blinding retinal diseases, such as Stargardt d

67 ation (AMD), are among the leading causes of incurable blindness in the Western world [1].

68 s the efficacy of therapeutic strategies for incurable bone metastatic prostate cancer is an urgent n

69 Chordoma is a malignant, often incurable bone tumour showing notochordal differentiatio

70 Multiple myeloma is an incurable, bone marrow-dwelling malignancy that disrupts

71 Glioblastoma is an incurable brain cancer characterized by high genetic and

72 Glioblastoma remains an incurable brain cancer.

73 als with Creutzfeldt-Jakob disease (CJD), an incurable brain disorder caused by alterations in prion

74 Glioblastoma is an incurable brain tumor notorious for its heterogeneity.

75 Diffuse intrinsic pontine gliomas (DIPG) are incurable brain tumors with an aggressive onset.

76 Advanced stage follicular lymphoma (FL) is incurable by conventional therapies.

77 helial carcinoma of the bladder is generally incurable by current chemotherapy and leads to early mor

78 Multiple myeloma is incurable by standard approaches because of inevitable r

79 tients with advanced prostate cancer that is incurable by surgery or radiation.

80 iated, myxoid/round cell, or pleomorphic LPS incurable by surgery or radiotherapy were included.

81 Heritable mutations in ABCC6 underlie the incurable calcification disorder pseudoxanthoma elasticu

82 atment: Metastatic melanoma, once considered incurable, can now be treated with potentially curative

83 of a Middle Eastern adolescent patient with incurable cancer and conducted an ethical analysis incor

84 le-blind trials in patients with advanced or incurable cancer and weight loss of 5% or more.

85 study drug response in multiple myeloma, an incurable cancer of the bone marrow.

86 110 patients with advanced, incurable cancer participated.

87 support program for patients with advanced, incurable cancer to assist them in discussing prognosis

88 Conclusion Patients with incurable cancer who received EIPC showed increased use

89 ctal adenocarcinoma (PDAC) is an aggressive, incurable cancer with a 20% 1 year survival rate.

90 Glioblastoma is a fatal and incurable cancer with the hyper-activated mTOR pathway.

91 aldenstrom macroglobulinemia remains a rare, incurable cancer, with a heterogeneous disease course.

92 , and mood in patients with newly diagnosed, incurable cancer.

93 a (MPM) is a highly aggressive and generally incurable cancer.

94 uld increase ER stress beyond repair in this incurable cancer.

95 L and mood in patients with newly diagnosed, incurable cancer; however, the use of certain coping str

96 Conclusion For patients with newly diagnosed incurable cancers, early integrated PC improved QOL and

97 cer patient care, especially in advanced and incurable cancers.

98 e, palliate symptoms, and control disease in incurable cancers.

99 ntial for treating many classes of currently incurable cancers.

100 tection from infection, and at the origin of incurable cancers.

101 ment, although initially effective, leads to incurable castration-resistant prostate cancer (CRPC) vi

102 r, patients receiving ADT eventually develop incurable castration-resistant prostate cancer (CRPC).

103 n (AD) therapy failure leads to terminal and incurable castration-resistant prostate cancer (CRPC).

104 tually all patients will relapse and develop incurable castration-resistant prostate cancer (CRPC).

105 iffuse intrinsic pontine gliomas (DIPGs) are incurable childhood brainstem tumors with frequent histo

106 Primary sclerosing cholangitis (PSC) is an incurable cholangiopathy of unknown etiopathogenesis.

107 Bardet-Biedl syndrome (BBS) is a currently incurable ciliopathy caused by the failure to correctly

108 tive and targeted interventions against this incurable condition.

109 rn opens up new therapeutic avenues for this incurable condition.

110 reat these highly debilitating and currently incurable conditions.

111 al plexus injury (NBPI) causes disabling and incurable contractures, or limb stiffness, which result

112 he most aggressive brain tumors that remains incurable despite advancements with treatment modalities

113 gnancy of plasma cells, has remained largely incurable despite dramatic improvements in patient outco

114 Multiple myeloma is largely incurable, despite development of therapies that target

115 Alzheimer's dementia is a devastating and incurable disease afflicting over 35 million people worl

116 Recurrent breast cancer is typically an incurable disease and, as such, is disproportionately re

117 ystrophic epidermolysis bullosa (RDEB) is an incurable disease caused by mutations in the gene encodi

118 Chronic lymphocytic leukemia (CLL) is an incurable disease characterized by accumulation of clona

119 HIV-1 causes a chronic, incurable disease due to its persistence in CD4+ T cells

120 Furthermore, CLL is still an incurable disease due to the persistence of residual leu

121 Metastatic melanoma remains an incurable disease for many patients due to the limited s

122 ioblastoma multiforme (GBM) remains a mainly incurable disease in desperate need of more effective tr

123 This incurable disease is caused primarily by the bacterium C

124 y arterial hypertension (PAH) is a medically incurable disease resulting in death from right ventricu

125 minal illness acknowledgment, recognition of incurable disease status, knowledge of the advanced stag

126 advances in therapy, glioblastoma remains an incurable disease with a dismal prognosis.

127 CLL is an incurable disease with a heterogeneous clinical course,

128 ced or metastatic urothelial carcinoma is an incurable disease with limited treatment options, especi

129 ld offer potential new therapies for CRSwNP (incurable disease).

130 However MCL remains a largely incurable disease, and following relapse, it can be a ch

131 rgeted, and multiple myeloma (MM) remains an incurable disease.

132 potential opportunity for treatment of this incurable disease.

133 hronic lymphocytic leukemia (CLL) remains an incurable disease.

134 bination therapies for the treatment of this incurable disease.

135 ose and patients often present with advanced incurable disease.

136 o the development of an indolent and largely incurable disease.

137 er (SCLC) at advanced stage is considered an incurable disease.

138 therapeutic target for the treatment of this incurable disease.

139 utes a potential therapeutic target for this incurable disease.

140 r therapeutic intervention in this otherwise incurable disease.

141 us cell cancer (ESCC) present with advanced, incurable disease.

142 patients under cART makes HIV-1 infection an incurable disease.

143 TR mutations cause cystic fibrosis, a lethal incurable disease.

144 Ataxia Type 3 (SCA3), one of nine inherited, incurable diseases caused by similar mutations.

145 re toxic, causing or contributing to severe, incurable diseases including Alzheimer's and prion disea

146 s report discusses how a number of currently incurable diseases might be treated by advances develope

147 ting peripheral neuropathies are progressive incurable diseases without effective treatment.

148 ic and induced) for regenerative medicine of incurable diseases, immunotherapy and blood transfusions

149 t stem cell replication and cause a range of incurable diseases, including dyskeratosis congenita (DC

150 expansions are responsible for more than 30 incurable diseases.

151 o offer unproven procedures to patients with incurable diseases.

152 peutic alternative for many debilitating and incurable diseases.

153 s to vaccination, implantation, and treating incurable diseases.

154 ues of patients with a wide range of serious incurable diseases.

155 increasing because of their contribution in incurable diseases.

156 apulohumeral muscular dystrophy (FSHD) is an incurable disorder linked to ectopic expression of DUX4.

157 ial hypertension (PAH) is a rare, fatal, and incurable disorder.

158 ase, and its genetic defect causes different incurable disorders.

159 options for ALL in general and may suppress incurable drug-resistant leukemia forms.

160 HIV infection is incurable due to a long-lived reservoir of HIV(+)memory

161 is a plasma cell malignancy that is largely incurable due to development of resistance to therapy-el

162 diagnostic and therapeutic tools, AD remains incurable due to its complex and multifactorial nature a

163 espite recent advances in treatment, remains incurable due to molecular heterogeneity of tumor cells.

164 e sarcoma and soft-tissue sarcomas (STS) are incurable due to the inability to eradicate chemoresista

165 atic and castration-resistant cancer remains incurable due to the lack of effective therapies.

166 aging hematopoietic system and are currently incurable due to therapy-resistant, disease-reinitiating

167 ia in the western countries and is currently incurable due, in part, to difficulty in eliminating the

168 ecurrent/metastatic (R/M) ACCs are generally incurable, due to a lack of active systemic therapies.

169 Millions of people worldwide with incurable end-stage lung disease die because of inadequa

170 option for patients suffering from otherwise incurable end-stage pulmonary diseases such as chronic o

171 sure for a clinical trial to treat currently incurable eye diseases severely affecting cone vision de

172 Spasmodic dysphonia (SD) is an incurable focal dystonia of the larynx that impairs spee

173 ntinues to increase, and the disease remains incurable for many due to its metastatic nature and high

174 volves blood, bone marrow, and spleen and is incurable for most patients.

175 thic pulmonary fibrosis (IPF) is a fatal and incurable form of interstitial lung disease in which per

176 for patients with refractory NB, thus far an incurable form of this disease.

177 t of therapeutic interventions for presently incurable forms of advanced cancer.

178 uired to develop new therapies for currently incurable forms of AMD.

179 Friedreich's ataxia is an incurable genetic disorder caused by a mutant expansion

180 umour microtubes mediates the progression of incurable gliomas.

181 Endometriosis is an incurable gynecological disorder characterized by debili

182 Patients were considered incurable, had measurable disease, and were treated with

183 Multiple myeloma is an incurable haematological malignancy, representing over 1

184 mediastinal nonseminomatous GCTs develop an incurable hematologic malignancy and prior data intrigui

185 eoplasm (BPDCN) is an aggressive and largely incurable hematologic malignancy originating from plasma

186 Currently, CTCL is incurable, highlighting the need for new therapeutic mod

187 Light chain (AL) amyloidosis is an incurable human disease characterized by the misfolding,

188 protein ion channels underlie many currently incurable human diseases.

189 erative transmissible agents causing several incurable illnesses in humans and animals.

190 ions in 68% of ICCs and that the disease was incurable in 85% of ICCs.

191 Stage III/IV melanoma remains incurable in most cases due to chemotherapeutic resistan

192 ecade, multiple myeloma (MM) remains largely incurable, indicating a need for new treatment approache

193 Endometriosis is a common incurable inflammatory disorder that is associated with

194 Herpesviruses, including HCMV, persist in an incurable, latent state that has profound implications f

195 es to conquest the liver cancer, a currently incurable lethal disease.

196 iety and Depression Scale) within 8 weeks of incurable lung or GI cancer diagnosis.

197 data from 350 patients with newly diagnosed incurable lung or GI cancer.

198 domly assigned patients with newly diagnosed incurable lung or noncolorectal GI cancer to receive eit

199 licular lymphoma, traditionally viewed as an incurable lymphoma, the aim of treatment is to control d

200 PEL is an incurable malignancy and has extremely poor prognosis wh

201 lly diagnosed breast cancer, is typically an incurable malignancy due to the lack of targetable surfa

202 Multiple myeloma (MM) remains an incurable malignancy due, in part, to the influence of t

203 lear cell renal cell carcinoma (CCRCC) is an incurable malignancy in advanced stages and needs newer

204 Primary effusion lymphoma (PEL) is a largely incurable malignancy of B cell origin with plasmacytic d

205 Multiple myeloma (MM) is a nearly always incurable malignancy of plasma cells, so new approaches

206 Follicular lymphoma is an incurable malignancy, with transformation to an aggressi

207 nts afflicted with this aggressive and often incurable malignancy.

208 er gene in chordoma.Chordoma is a rare often incurable malignant bone tumour.

209 e within 10 years and eventually progress to incurable metastatic disease.

210 00 US deaths annually, attributed largely to incurable metastatic disease.

211 the potential to treat an extensive range of incurable monogenic and complex diseases.

212 is and frontotemporal lobar degeneration are incurable motor neuron diseases associated with muscle w

213 Joubert syndrome (JBTS) is an incurable multisystem ciliopathy syndrome.

214 al muscular dystrophy (FSHD) is a prevalent, incurable myopathy, linked to epigenetic derepression of

215 al muscular dystrophy (FSHD) is a prevalent, incurable myopathy, linked to hypomethylation of D4Z4 re

216 The devastating effects and incurable nature of hereditary and sporadic retinal dise

217 lin-mutant mouse models of the inherited and incurable nerve disorder, Charcot-Marie-Tooth (CMT) neur

218 Retinitis pigmentosa (RP) is an incurable neurodegenerative condition featuring photorec

219 Spinocerebellar ataxia type 1 (SCA1) is an incurable neurodegenerative disease caused by a pathogen

220 ophy (GLD; Krabbe disease) is a progressive, incurable neurodegenerative disease caused by deficient

221 ophic lateral sclerosis (ALS) is a fatal and incurable neurodegenerative disease caused by motor neur

222 on aaRS-associated monogenic disorder is the incurable neurodegenerative disease Charcot-Marie-Tooth

223 terest since its depletion was linked to the incurable neurodegenerative disease Friedreich's ataxia

224 This incurable neurodegenerative disease is the most prevalen

225 Sporadic Alzheimer's disease (AD) is an incurable neurodegenerative disease with clear pathologi

226 Parkinson's disease (PD) is an insidious and incurable neurodegenerative disease, and represents a si

227 lateral sclerosis (ALS) is a devastating and incurable neurodegenerative disease, characterised by pr

228 nted promise for the treatment of this still incurable neurodegenerative disease.

229 ateral sclerosis (FTD/ALS) are insidious and incurable neurodegenerative diseases that represent a si

230 Parkinson disease is a debilitating and incurable neurodegenerative disorder affecting approxima

231 Alzheimer's disease is an incurable neurodegenerative disorder in which neuroinfla

232 To find new keys to this incurable neurodegenerative disorder we focused on the p

233 Q) tract and causes Huntington's disease, an incurable neurodegenerative disorder(2).

234 the mainstay of symptomatic therapy for this incurable neurodegenerative disorder.

235 isease (AD) and similar dementias are common incurable neurodegenerative disorders in the aging popul

236 scinoses (NCLs) are a group of inherited and incurable neurodegenerative disorders primarily afflicti

237 Prion diseases are a group of incurable neurodegenerative disorders that affect humans

238 Rett syndrome is an incurable neurodevelopmental disorder caused by mutation

239 Amyotrophic lateral sclerosis (ALS) is an incurable neurological disease with progressive loss of

240 fidence in legitimate stem cell research for incurable neurological diseases such as multiple scleros

241 Myotonic dystrophy type 1 (DM1) is an incurable neuromuscular disorder caused by an expanded C

242 Cutaneous T-cell lymphoma (CTCL) is an incurable non-Hodgkin lymphoma of the skin-homing T cell

243 lief of malignant dysphagia in patients with incurable oesophageal cancer.

244 n (Ig)-secreting plasma cells and remains an incurable, often lethal disease despite therapeutic adva

245 Multiple myeloma is incurable once osteolytic lesions have seeded at skeleta

246 veral tuberculosis-endemic countries to drug-incurable or programmatically incurable tuberculosis (to

247 anti-oxidant treatment efficacy in currently incurable oxidative stress-based forms of hearing loss.

248 f low-risk PC and, conversely, lower risk of incurable PC and lower PC mortality.

249 iffuse intrinsic pontine glioma (DIPG) is an incurable pediatric brain tumor, with approximately 25%

250 roups and novel therapeutic targets for this incurable pediatric cancer.

251 diffuse intrinsic pontine glioma (DIPGs), an incurable pediatric cancer.

252 mpelling therapeutic target for this largely incurable pediatric tumor and demonstrate important adva

253 is pigmentosa (RP), an inherited and largely incurable photoreceptor degenerative disease, is unclear

254 Multiple myeloma is an incurable plasma cell cancer selectively localized in th

255 Multiple myeloma is an incurable plasma cell malignancy with a complex and inco

256 Although incurable, prion disease follows a clear pathogenic mech

257 otoreceptor degenerations (IPDs), a group of incurable progressive blinding diseases, are caused by m

258 s an early inflammatory phase followed by an incurable progressive phase with subdued inflammation an

259 s a promising therapeutic strategy for these incurable Ras-driven tumors and highlight the utility of

260 study of participants with untreated locally incurable recurrent or metastatic HNSCC done at 200 site

261 nown as retinal degeneration slow/RDS) cause incurable retinal degeneration with a high degree of phe

262 involvement (4 [6.7%]), or other (8 [13.3%]) incurable sites.

263 al muscular dystrophy (FSHD) is a prevalent, incurable skeletal myopathy.

264 ed (ie, unresectable or metastatic, or both) incurable solid tumour (eligible tumour types were anal,

265 confirmed diagnosis of advanced, malignant, incurable solid tumours from University of California at

266 HSV infections represent an incurable source of morbidity and mortality in humans an

267 ary tumor should be removed in patients with incurable stage IV colorectal disease.

268 , most pancreatic cancers are detected at an incurable stage owing to the absence of disease-specific

269 gh likelihood of progression to an advanced, incurable stage.

270 Does the dogma that multiple myeloma is incurable still hold?.

271 herapies, glioblastoma (GBM) patients remain incurable, thus justifying the urgent need of new therap

272 ntries to drug-incurable or programmatically incurable tuberculosis (totally drug-resistant tuberculo

273 203 (74%) had programmatically incurable tuberculosis and unfavourable outcomes (treatm

274 The emergence of programmatically incurable tuberculosis threatens to destabilise control

275 n half of the patients with programmatically incurable tuberculosis were discharged into the communit

276 Glioblastoma is an incurable tumor, and the therapeutic options for patient

277 ; grade 4 glioma) is a highly aggressive and incurable tumor.

278 1-deficient lymphocytes induced rejection of incurable tumors and promoted protection against tumor r

279 rpes simplex virus 1 (HSV-1) infection is an incurable viral infection with the most significant morb

280 cting the macula constitute a major cause of incurable vision loss and exhibit considerable clinical

281 degeneration (AMD), the most common cause of incurable vision loss in the elderly worldwide.

282 is a leading cause of blindness resulting in incurable visual impairment and drastic reduction in the

283 utations of Crb1 gene cause irreversible and incurable visual impairment in humans.

284 ressive neurodegenerative disease, currently incurable, which presents one of the largest unmet needs

285 tients with acute myeloid leukemia (AML) are incurable with chemotherapy and may benefit from novel a

286 Follicular lymphoma (FL) is incurable with conventional therapies and has a clinical

287 Recurrent glioblastoma multiforme (GBM) is incurable with current therapies.

288 with distant organ metastases is considered incurable with currently available therapies.

289 midline high-grade astrocytomas (mHGAs) are incurable with few treatment targets identified.

290 in lymphomas, these lymphomas remain largely incurable with standard therapies.

291 on B-cell non-Hodgkin lymphoma (NHL) that is incurable with standard therapies.

292 Indolent non-Hodgkin's lymphomas (iNHLs) are incurable with standard therapy and are poorly responsiv

293 However, CLL remains largely incurable, with drug resistance and treatment relapse a

294 are primary brain tumours that are generally incurable, with heterogeneous prognosis and few treatmen

295 This malignancy is considered virtually incurable, with high response rates to therapy but frequ

296 all therapeutic efforts, they remain largely incurable, with the most aggressive forms being lethal w

297 MM is essentially incurable without a means of early diagnosis and no succ

298 Duchenne muscular dystrophy (DMD) is an incurable X-linked genetic disease that is caused by a m

299 Duchenne muscular dystrophy (DMD) is an incurable X-linked muscle-wasting disease caused by muta

300 sis of luminal breast cancer is frequent and incurable, yet the metastasis mechanisms are poorly unde