ライフサイエンスコーパス: independent

1 significance, suggesting that it is therapy independent.

2 need to be quantitative and user and machine independent.

3 These species-independent A(3)AR-selective nucleosides are low efficac

4 This device enabled independent access to the apical and basolateral surface

5 Data independent acquisition (DIA) has potential as a high-th

6 pression of the target mRNA than expected by independent action at each site.

7 e modality-specific activation from modality-independent activation.

8 t STING controls HSV-1 infection through IFN-independent activities.

9 Our approach uses two independent adaptive evolution steps to address the lack

10 The primary outcome, assessed by an independent adjudication committee masked to treatment a

11 itions can be converted into potent FcgammaR-independent agonists with remarkable antitumor activity

12 s result was consistent with increased renin-independent aldosterone production and hypertension.

13 Independent analyses across technologies demonstrated th

14 Independent analyses of enhancers showed an excess of DN

15 tle empirical work has examined the possible independent and joint effects of these factors upon rewa

16 We aimed to determine the independent and simultaneous effects of OSE and ER on sa

17 atistical analysis treats all data points as independent and thus fully contributing to the result.

18 agonists 4-OI and DMF induce a distinct IFN-independent antiviral program that is broadly effective

19 R-1 modulates both Dicer-dependent and Dicer-independent Argonaute pathways and provide insight into

20 t is essential for both the prenatal hormone-independent as well as the pubertal hormone-dependent br

21 ) data from 22,236 mosquitoes tested from 96 independent assays.

22 egression analysis was performed to test the independent association between periodontal conditions a

23 In our study, the independent association of GPS with AP after initial act

24 etected 122 significant (P < 1.28 x 10(-11)) independent association signals for 459 cell traits at 7

25 9,488), we aimed to test the cross-sectional independent associations and joint interaction effects o

26 chanism by which E449K activates Int for gp3-independent attL x attR recombination.

27 Independent baseline predictors of clinical responder st

28 However, the three studies were not independent because of the large overlap in their partic

29 Finally, we provide insight into BP-independent biological pathways underlying SVD and sugge

30 N = 60) from the same individuals and in two independent brain collections (BA10, N = 81 and 64).

31 a subset of the observed associations in an independent case-control study of type 2 diabetes.

32 ent's treatment allocation until the blinded independent central review (BICR) showed progressive dis

33 In this sense, nucleus-independent chemical shift (NICS) and anisotropy of the

34 ator genes followed by validation testing in independent children with severe asthma (n = 21) and mil

35 Exploratory analyses in independent clinical datasets show that PRSs were associ

36 Gene ontology analysis of three independent clinical GC cohorts revealed significant inv

37 iable linear regression was used to identify independent clinical predictors of each outcome.

38 In the present study, 12 independent clones were obtained and were invariably ALA

39 Mycotypes were also seen in an independent cohort of 24 subjects, in which cultivation

40 ated the reproducibility of these ICNs in an independent cohort of HCs, and recapitulated their funct

41 Epigenetic age results were confirmed in an independent cohort of healthy controls.

42 r chronic) were confirmed in the urine of an independent cohort of IgAN patients compared with non-Ig

43 This biomarker generalized to a drug-free independent cohort of melancholic MDD, and did not gener

44 and external validation was performed in an independent cohort with primary chemotherapy from Heidel

45 y controls and validated these results in an independent cohort.

46 The authors retrospectively analyzed two independent cohorts of patients who received left prefro

47 -seq were biomarkers of clinical outcomes in independent cohorts.

48 ulosis and evaluated its predictive value in independent cohorts.

49 /DREB binding factor (CBF)-dependent and CBF-independent cold signaling pathways to tolerate cold.

50 t of participants' care, and monitored by an independent committee using an adaptive approach with in

51 ifying enrichment and creating features with independent complementary data sources can be implemente

52 HD-EEG data were analysed using independent component analyses, source localization and

53 A group-wise independent component analysis demonstrated that all pre

54 cally, such as principal component analysis, independent component analysis, non-negative matrix fact

55 We conducted an independent, confidential, voluntary, web-based survey s

56 atural model system for studying microtubule-independent cytoskeletal phenotypes.

57 ately associated with all-cause mortality in independent data within the UK Biobank: the estimated ha

58 of disease activity need to be replicated in independent datasets and, if validated, may provide usef

59 l regulation of tankyrase serves as a ligand-independent developmental mechanism for post-translation

60 in hepatocellular carcinoma (HCC) and is an independent diagnostic marker predicting the poor progno

61 upper arm circumference (MUAC) is used as an independent diagnostic tool to detect wasting in childre

62 use genome-wide off-target changes via sgRNA-independent DNA deamination.

63 -1-27-12 (C. moschata) is conferred by three independent dominant genes (R1R2R3).

64 gnaling by collagens is likely to be contact independent due to physical separation of the cuticle fr

65 We further validate these independent effects for one RA in vitro.

66 We also examined the independent effects of a certain particle metric in two-

67 Here, we show that Stattic exerts many STAT3-independent effects on cancer cells, calling for reasses

68 controls and performing meta-analyses with 2 independent EoE genome-wide association studies.

69 plitudes in cryo-EM, and that half-maps with independent errors are available in cryo-EM.

70 Global Tic Severity Scale administered by an independent evaluator before and after each arm.

71 ion and aggregation of the SOD1 variants are independent events.

72 cteristics despite over 300 million years of independent evolution and being implemented by distinct

73 om a separate institution were set aside for independent external validation.

74 gression analysis was undertaken to identify independent factors associated with risk of death during

75 Independent factors significantly associated with higher

76 1 in the PI3K signaling cascades in a ligand-independent fashion.

77 winds ~2 turns of the double helix in an ATP-independent fashion.

78 r photoproduct yields are explained by donor-independent, fast charge recombination with rates of ~0.

79 howed the highest levels of ILC2s, which was independent from atopy or serum tryptase levels.

80 ble component to self-harm that is partially independent from comorbid psychiatric disorders.

81 accuracy of VNC images from SDCT is high and independent from dose, kernel, and denoising settings; h

82 in relation to the actual world, rather than independent from it.

83 d that they represent state values and arise independent from somatic spiking activity.

84 bset of signatures across the entire library independent from the originating source, project or assa

85 Overall, this work establishes the spindle-independent function of NuMA in choreographing proper ch

86 ta show that DNA-PK has RNA-dependent, cNHEJ-independent functions during ribosome biogenesis that re

87 own phenotype, demonstrating centralspindlin-independent functions.

88 he beta(2)AR exhibits a low level of agonist-independent G protein activation.

89 l parabrachial is also found with genes from independent genetic studies.

90 mum of GWAS and GWAX, based on the number of independent genome-wide-significant loci across all dise

91 in vivo and in vitro and complemented biotin-independent growth of the M. smegmatis tam deletion muta

92 for suppressing cell migration and anchorage-independent growth.

93 We further replicated 50 genes in an independent GWAS, including one of the two novel loci.

94 oglobin-encoding genes were acquired through independent horizontal gene transfer events from differe

95 ing may help prevent hospitals from becoming independent 'hubs' of SARS-CoV-2 transmission, and illus

96 has not been previously quantified in three independent human cohorts.

97 A new Abeta-independent hypothesis emerges where the amyloidogenic p

98 gen-activated protein kinase-dependent Ripk1-independent IL-1 and tumor necrosis factor production, a

99 measure could be employed as a robust, task-independent index of interpersonal behaviour.

100 mined the HIV-inhibitory effects of the MTOR-independent inducer of autophagy, trehalose.

101 ny size and viability provide complementary, independent information.

102 ld domain and the hairpin, exhibited hormone-independent interactions with PhMAX2A and PhD53A, respec

103 We inferred three independent introductions of rats, including to Suouroy,

104 and phylogenetic analyses indicate multiple independent introductions to Guangdong, although phyloge

105 ere consistent with those reported before in independent investigations.

106 erpretation of results were performed by two independent investigators in accordance with the PRISMA

107 rge from the cumulative effects of multiple, independent local adaptation events along latitudinal en

108 Ubqln4 engages the J proteins in a J-domain-independent manner, in contrast to the previously report

109 in a Tir-dependent but actin polymerisation-independent manner, which was enhanced by priming with i

110 l of iCGI transcription in a DNA-methylation independent manner.

111 ed by mannose 6-phosphate, suggesting cation-independent, mannose 6-phosphate receptor-mediated endoc

112 tility of serum sphingolipids as cholesterol-independent markers of risk and even future targets for

113 s were interpreted by the majority rule of 3 independent masked readers.

114 s to light through an arrestin-translocation-independent mechanism.

115 Zika virus through a type I interferon (IFN)-independent mechanism.

116 derived metabolite, and identify an excision-independent mechanism.

117 Therefore, understanding the p53-independent mechanisms of the netrin-UNC5B axis, such as

118 ration through an array of tau-dependent and independent mechanisms.

119 mmune dysregulation via kinase dependent and independent mechanisms.

120 Drosophila to form sleep-dependent and sleep-independent memory.

121 are associated with breast cancer risk in an independent meta-analysis (P < 0.05).

122 rbecovirus alignment were removed with three independent methods.

123 The mass-independent minor oxygen isotope compositions (Delta'(17

124 rid and mesenchymal phenotypes arise through independent molecular paths.

125 , which could cause salicylic acid- and EDS5-independent mutant phenotypes.

126 system, further demonstrating its catalysis-independent nature.

127 at lacks gC was more sensitive to complement-independent neutralization by a panel of gB monoclonal a

128 3) (+)) or, alternatively, a proton transfer-independent nucleophilic ferric peroxo anion (compound 0

129 otal SOC predicted by MIMICS agree well with independent observations from globally distributed fores

130 and agreement with scores assigned by eight independent observers were measured using receiver opera

131 tricts disinhibition and gates OD plasticity independent of a canonical cortical microcircuit.

132 ce shows a direct effect of fecal microbiota independent of active liver inflammation or injury.

133 stently associated with higher T2D/IGT risk, independent of adiposity.

134 id aggregation in certain cases, while being independent of aggregation in other cases.

135 ificantly with complement activation levels, independent of AMD status.

136 nal factors and early respiratory infections independent of atopy.

137 sensitive compared with control (CON) women, independent of BMI.

138 equently migrate randomly on the sinus floor independent of both chemokines and integrins.

139 that predicted death-censored graft failure independent of both donor and recipient clinical charact

140 Importantly, these effects were independent of changes in actomyosin contractility.

141 6% increases in vertebral artery blood flow, independent of changes in end-tidal PCO2 and blood press

142 mixing, whereas the rate of lipid mixing is independent of cholesterol composition.

143 Independent of compromised ISVP stability, we also found

144 isease are decreasing the demand for imaging independent of COVID-19.

145 boundaries of the MFC in all three species, independent of cytoarchitectonic definitions.

146 We found that m(6)A QTLs are largely independent of expression and splicing QTLs and are enri

147 P(PRS)=2.7x10(-11) per SD increase in PRS), independent of family history and smoking risk factors (

148 aining interaction diversity are similar and independent of geography.

149 Incidences of NADM or CVD were independent of HCV group, whereas those cured had substa

150 etic programming via signaling that is often independent of IGFs.

151 way induced cellular signals constitutively, independent of IL-1beta stimulation, which was abrogated

152 connectivity between cortical motor networks independent of individual deficit severity.

153 y contribute to the pathogenesis of delirium independent of inflammation.

154 enerative processes that are at least partly independent of inflammatory mechanisms can develop early

155 with a decreased likelihood of schizophrenia-independent of intelligence-and, hence, may be entangled

156 cing confirmed that germ cells die as clones independent of intercellular bridges, suggesting that sh

157 This effect is largely independent of ISG15 conjugation and relies on ISG15 fun

158 on, we showed that Prima-1(Met) activity was independent of its canonical target, mutant p53, and was

159 d dependence after intracerebral hemorrhage, independent of known predictors of outcome.

160 ciated with improved OS (HR 0.53, P < 0.002) independent of KRAS status and other clinicopathologic f

161 productivity of a critical functional group, independent of live coral loss.

162 r [LV] ejection fraction [LVEF] >= or < 50%) independent of LV structure and function.

163 sociation between VPA and LVNC phenotype was independent of LV volumes.

164 Obesity remains a risk factor for CVD independent of major metabolic factors.

165 epsilonRI regulation by 1,25(OH)(2)-D(3) was independent of maturation and expression levels of micro

166 B2 stability by impairing its ubiquitination independent of methyltransferase activity or PRC2, there

167 This cue-specific activity was independent of motor-related activity and thus tracked s

168 ic transmission by a novel mechanism that is independent of neurexins and neuroligins.

169 association with obesity duration persisted, independent of obesity severity.

170 a complication, as well as 30-day mortality, independent of other hospital level characteristics incl

171 ge, shock, lung injury and improved survival independent of pancreatic injury.

172 Interestingly, this interaction is independent of Parkin mitochondrial recruitment and liga

173 mitter filled vesicles release their content independent of presynaptic action potentials (APs).

174 dependent changes in COX-2 activity that are independent of protein expression within live macrophage

175 This effect on ETC complexes appears to be independent of protein lipoylation, the best characteriz

176 e physiological changes were mechanistically independent of protein synthesis but sensitive to pharma

177 h scores of the personality trait constraint independent of sex or age.

178 All associations were independent of socio-demographics and vascular risk fact

179 ect on ascorbic acid, which declined rapidly independent of storage temperature.

180 emonstrated a pattern of temporal dispersion independent of stroke location.

181 and fecal microbiome vs control individuals, independent of symptom-based subtypes of IBS.

182 agenesis show that CDK7 activation can occur independent of T-loop phosphorylation and is thus exclus

183 CD8(+) T cell effector cytokine R production independent of TCR Ag affinity.

184 n can score well as most of the features are independent of the accumulated literature.

185 g surface and that T(reg) cell expansion was independent of the antibody Fc region.

186 HDAC6-microtubule interactions are entirely independent of the catalytic domains and are mediated by

187 mote T(H)2-cell differentiation in the lung, independent of the draining lymph nodes.

188 m yield (QY) and lifetime values were almost independent of the flanking bases.

189 gent-activated Wnt/beta-catenin signaling is independent of the FZD/LRP heterodimeric receptors and W

190 at phosphorus favors this coordination mode, independent of the initial configuration of the ligand,

191 al form of these enzymes, as its activity is independent of the nucleic acid type (RNA or DNA), its s

192 Surprisingly, Ndc80 complex clustering is independent of the organization and number of its centro

193 ght account for the association at HLA-DRB1, independent of the previously reported HLA-DPB1 variants

194 ntally shown that the correction function is independent of the reagent ion used.

195 f PSMA PET-positive patients to all patients independent of the reference standard, whereas the CDR w

196 settings, RB loss rendered cells completely independent of these kinases.

197 Moreover, independent of this activity, Trx1 is critical for NLRP3

198 upregulated myofibroblast-specific ECM genes independent of topography, but only fibroblasts on flat

199 we found that the effects of FGIN-1-27 were independent of translocator protein (TSPO), the reported

200 ks of orientation preference initially arise independent of visual experience, experience is critical

201 rientation tuning is anchored to gravity and independent of visual landmarks.

202 ling contributes to macronutrient preference independent of VSG, while removal of CD36 signaling blun

203 In two independent ongoing next-generation sequencing projects

204 An additional independent origin of endogenous bioluminescence is foun

205 The excellent immunotherapy-independent outcomes of autoantibody-positive patients w

206 nts (EPSCs) are followed by GABA(A) receptor-independent outward currents, reflecting the hyperpolari

207 ment, TfR1 was endocytosed in an AP2- and Tf-independent pathway and trafficked to the lysosome for d

208 tic to LLS1, and LLS1 works with PALM1 in an independent pathway to regulate the growth of lateral le

209 en resistance via both ERalpha dependent and independent pathways.

210 detected in TNBC, and interrogation of four independent patient cohorts detected BCL2L14-ETV6 in 4.4

211 producible, predicted symptom improvement in independent patient cohorts, and were specific to active

212 Sequencing tumor biopsies of 20 independent patients with MSI colorectal cancer revealed

213 p85beta activates p110 activity and AKT-independent PDK1/SGK3 signaling to promote tumorigenic p

214 ly hydrophilic and exhibit unique excitation independent photoluminescence emission, attributed to th

215 eighted by allelic effects established in an independent population.

216 Integrated models, if validated in independent populations, could provide novel clues conce

217 ery disease, (18)F-NaF PET provides powerful independent prediction of fatal or nonfatal myocardial i

218 an the liver background after therapy was an independent predictor for improved PFS and OS and can be

219 scatheter aortic valve replacement and is an independent predictor of 30-day mortality, irrespective

220 QRS fragmentation was the only independent predictor of appropriate ICD therapies (haza

221 Female sex was not an independent predictor of mortality at 10 years in patien

222 After multivariate analysis, EMW remained an independent predictor of symptomatic status (odds ratio

223 aving treatment for CLTI or DFI in P2 was an independent predictor of worse primary patency rate and

224 The LVIDs and IVC collapsibility were independent predictors for mortality, together with base

225 onse Evaluation Criteria in Solid Tumors) as independent predictors of CSS.

226 nd GRS score >0.597 (HR 2.30, P = 0.04) were independent predictors of de novo HCC.

227 he interaction between CT and HPV16 remained independent predictors of HGAIN.

228 tive performance (P = 0.05) were significant independent predictors of higher tau accumulation rates.

229 Independent predictors of infection were injection drug

230 pathies on MRI, and p53 expression <15% were independent predictors of lower disease-free survival.

231 The proposed PANAMA-score, based on independent predictors of postresection survival, includ

232 om intrauterine growth restriction (IUGR) as independent predictors of ROP, we performed a retrospect

233 tio, 1.63 [95% CI, 1.30-2.04]; P<0.001) were independent predictors of the primary end point.

234 Analogous patterns are observed for two independent proband cohorts and several other important

235 t forms of synaptic plasticity, yet activity-independent processes might also play some part.

236 -cerebral pathways that likely contribute to independent processes of learning.

237 hat overexpression of miR-21 was a potential independent prognostic biomarker of poorer OS (HR = 1.27

238 Morbidity was significant independent prognostic factors for overall survival (Rel

239 This is the first study to use CMR to assess independent prognostic implications of functional TR.

240 Our objective was to evaluate the independent prognostic value of a novel MRI biomarker-ob

241 ell layer capacitance and TEER represent two independent properties characterizing the monolayer.

242 ndent antigens, the conjugates also retain T-independent properties, leading to detrimental effects o

243 hm yields useful reproducible results on two independent prospective cohorts of ED patients, future r

244 e train and test multiple classifiers on two independent prospective patient cohorts (n = 1244).

245 An independent, prospective, observational cohort study was

246 volves slowly and involves a phosphorylation-independent proteolytic pathway.

247 37 insertions per line in a population of 19 independent R1 regenerant plants analyzed.

248 plete or partial response) as assessed by an independent radiologic review committee according to the

249 Confirmed ORRs per independent radiology review and investigator assessment

250 makes a major enzymatic contribution to RecA-independent recombination.

251 inib targeted both Hippo-dependent and Hippo-independent regulation of YAP1, ablating rhabdomyosarcom

252 Through comparison with previous data, independent replicates and both inversion breakpoints, w

253 The ALSPAC birth cohort was used for independent replication.

254 dinary international collaborative effort of independent researchers who have recently all come to th

255 ly relevant tissue actions of TRPV4, stretch-independent responses, and underlying mechanisms are unk

256 ry endpoint was progression-free survival by independent review in the intention-to-treat population.

257 An independent reviewer-assessed overall response was achie

258 Higher baseline SAF was an independent risk factor for CVEs (hazard ratio [HR] 1.12

259 The FLIS was an independent risk factor for mortality in both patients w

260 ed with cGVHD severity but was a significant independent risk factor for overall mortality and nonrel

261 Albuminuria is an independent risk factor for the progression to end-stage

262 FTP grade IV is an independent risk factor for velum-CCC, controlling for s

263 tion, and lymphocytic bronchiolitis remained independent risk factors for DSA development.

264 Rare and common environmental exposures are independent risk factors for radiologic abnormalities.

265 The independent risk factors of long-term (beyond 12 mo) CVE

266 nce of LNM was 51/882 (6%) in absence of the independent risk factors.

267 hese models, disclosing a complementary, but independent role of caspase-8 and caspases-1/11/GSDM-D i

268 stmarketing reports, and assessments from an independent Safety Review Committee (SRC); and (3) their

269 This association was replicated in two independent samples of SJLIFE survivors of European ance

270 zability of results requires replications in independent samples.

271 Recent observations made with several independent satellite measurements demonstrate that seve

272 ARS-CoV-2 infection status, based on a fully independent set of indicators, that can help confirm res

273 f the embryo, is dispensable for both ligand-independent signaling pathway activation and ligand-resp

274 is high-quality information is spread across independent sources and researchers often need to access

275 events were consistent with action-potential-independent spontaneous glutamate release, suggesting pl

276 Thus, necroptosis is an independent, "stand-alone" cell death mechanism that ful

277 tions in the ligand-dependent and the ligand-independent states.

278 Interestingly, angular-independent structural colors, where isotropy in the sca

279 ng methods associated with meta-analysis for independent studies, despite using the same data twice i

280 Here, we conducted an independent study on 24 individuals with HVDAS and repli

281 In the second independent study, tuberculosis occurred in none of the

282 , SnRK2.6, SnRK2.7, and SnRK2.8, and the ABA-independent subclass 1 protein kinases SnRK2.1, SnRK2.4,

283 trategy for GPU architectures that is domain independent, supporting alignment of sequences from both

284 results suggest that a loss of NOD-LNSC MHC-independent suppressive mechanisms may contribute to dia

285 c CD4+ T cell repertoire, suggesting antigen-independent survival of this subset.

286 ghts and non-suicidal self-harm (NSSH) in an independent target sample of 8,703 Australian adults.

287 Classifier performance was assessed using an independent test dataset.

288 One training data set and an independent test set were collected from dbAMEPNI and so

289 Met-predictor was tested on two independent test sets, where the addition of structure m

290 previous state-of-the-art predictors on the independent test.

291 Because the 2 factors are statistically independent, the evidence they provide can be combined u

292 results underscore the importance of ligand-independent TNFR1 dimerization in NF-kappaB signaling.

293 We report that MCMV RNA contains a cap-independent translation element (CITE) in its 3' untrans

294 cases of bilateral neuroblastoma represented independent tumors in two children with pathogenic germl

295 Modality-independent V1 LPZ responses only in the task condition

296 rformed standard histologic assessment in an independent validation cohort of 56 additional cases.

297 s are analyzed using 16S rRNA sequencing; an independent Western cohort is used for external validati

298 stances containing entity relations as being independent, which neglects the interactions between rel

299 party members showed more in-group bias than Independents who professed the same political opinions.

300 Binding is sequence-independent with residues N13, R16, R17 and Q41 interact