ライフサイエンスコーパス: indoleamine

1 aled them as being similar to the endogenous indoleamine.

2 lation of circulating prostaglandin E(2) and indoleamine 2, 3,-dioxygenase enzymatic activity, as wel

3 HS suppressed mRNA and protein expression of indoleamine 2, 3-dioxygenase (IDO) and its activity upon

4 Production of indoleamine 2, 3-dioxygenase (IDO) by macrophages has re

5 recently shown that expression of the enzyme indoleamine 2, 3-dioxygenase (IDO) during murine pregnan

6 Indoleamine 2, 3-dioxygenase (IDO) is an immunoregulator

7 y modulating the expression of PD-L1; Tim-3; indoleamine 2, 3-dioxygenase (IDO); and interleukin 10.

8 The enzyme indoleamine 2, 3-dioxygenase (IDO-1) initiates and regul

9 Indoleamine 2, 3-dioxygenase 1 (IDO) catalyzes 1 rate-li

10 ly produced by both cell populations, unlike indoleamine 2, 3-dioxygenase which was only produced fol

11 tryptophan via the IFN-gamma-induced enzyme indoleamine 2, 3-dioxygenase.

12 , depletion of Gr1(+) cells or inhibition of indoleamine 2,3 dioxygenase (IDO) activity abrogates gra

13 Indoleamine 2,3 dioxygenase (IDO) activity during pregna

14 Indoleamine 2,3 dioxygenase (IDO) and arginase 1 (ARG1),

15 amino acid TRP, cells expressing the enzyme indoleamine 2,3 dioxygenase (IDO) can mediate potent loc

16 Indoleamine 2,3 dioxygenase (IDO) catabolizes the amino

17 Indoleamine 2,3 dioxygenase (IDO) has emerged as an impo

18 d expression of the immune regulatory enzyme indoleamine 2,3 dioxygenase (IDO) in local lymph nodes.

19 Indoleamine 2,3 dioxygenase (IDO) is a catabolic enzyme

20 xpression of the tryptophan-degrading enzyme indoleamine 2,3 dioxygenase (IDO) is selectively induced

21 ha(-/-) mice was likely because of a lack of indoleamine 2,3 dioxygenase (IDO), a critical regulator

22 e expression of interferon-gamma (IFNgamma), indoleamine 2,3 dioxygenase (IDO), and human leukocyte a

23 local draining lymph nodes (dLNs) to express indoleamine 2,3 dioxygenase (IDO), which confers T cell

24 aneously, pDCs up-regulate the expression of indoleamine 2,3 dioxygenase (IDO), which is essential fo

25 The roles of anergy and the indoleamine 2,3 dioxygenase (IDO)-tryptophan pathway in

26 tivating immunoregulatory mechanisms such as indoleamine 2,3 dioxygenase (IDO).

27 ressive factors IL-4, IL-10, CD274/PD-L1 and indoleamine 2,3 dioxygenase (IDO).

28 endent on the tryptophan catabolizing enzyme indoleamine 2,3 dioxygenase 1 (IDO1) in splenic macropha

29 The tryptophan-metabolizing enzyme indoleamine 2,3 dioxygenase 1 (IDO1) is frequently overe

30 , the SE inhibited the enzymatic activity of indoleamine 2,3 dioxygenase, a key enzyme in immune tole

31 Indoleamine 2,3 dioxygenase-1 (IDO-1) is an enzyme in th

32 Indoleamine 2,3 dioxygenase-1 (IDO1) catabolizes tryptop

33 y are associated with elevated expression of indoleamine 2,3 dioxygenase-1 (IDO1).

34 depend on inflammation-induced activation of indoleamine 2,3 dioxygenase-1 (IDO1).

35 duces depressive-like behavior by activating indoleamine 2,3 dioxygenase.

36 factor alpha (TNF-alpha) and upregulation of indoleamine 2,3-deoxygenase (IDO) but not of Toll-like r

37 ve immune functions, including production of indoleamine 2,3-deoxygenase.

38 physiological importance of human placental indoleamine 2,3-dioxygenase (EC 1.13.11.42), the first a

39 that inhibition of enzyme activity in human indoleamine 2,3-dioxygenase (hIDO) and a number of site-

40 Human indoleamine 2,3-dioxygenase (hIDO) is an intracellular h

41 Human indoleamine 2,3-dioxygenase (hIDO) is an intracellular h

42 han 2,3 dioxygenase (hTDO), and the other is indoleamine 2,3-dioxygenase (hIDO), both of which cataly

43 nt in heme-based dioxygenases, such as human indoleamine 2,3-dioxygenase (hIDO), was not recognized u

44 in humans: tryptophan dioxygenase (hTDO) and indoleamine 2,3-dioxygenase (hIDO).

45 teins, tryptophan 2,3-dioxygenase (hTDO) and indoleamine 2,3-dioxygenase (hIDO).

46 Pharmacological inhibition of indoleamine 2,3-dioxygenase (IDO) activity during murine

47 ther gamma interferon (IFN-gamma) can induce indoleamine 2,3-dioxygenase (IDO) activity in aortic smo

48 higher levels of gamma interferon-inducible indoleamine 2,3-dioxygenase (IDO) activity than endothel

49 ike receptor (TLR) 4 signaling, can regulate indoleamine 2,3-dioxygenase (IDO) activity, favoring TH2

50 cells could be attributed to their increased indoleamine 2,3-dioxygenase (IDO) activity.

51 (IgM), cytokine/granzyme concentrations, and indoleamine 2,3-dioxygenase (IDO) activity.

52 describe a subset of human APCs that express indoleamine 2,3-dioxygenase (IDO) and inhibit T cell pro

53 h a focus on the tryptophan catabolic enzyme indoleamine 2,3-dioxygenase (IDO) and its recently disco

54 ltiple immune inhibitory molecules including indoleamine 2,3-dioxygenase (IDO) and programmed cell de

55 inhibitory effect was primarily mediated by indoleamine 2,3-dioxygenase (IDO) and prostaglandin E2 (

56 omotes immune suppression through the enzyme indoleamine 2,3-dioxygenase (IDO) and subsequent product

57 tivated inflammatory macrophages can express indoleamine 2,3-dioxygenase (IDO) and thus actively depl

58 Indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dio

59 ortage of tryptophan caused by expression of indoleamine 2,3-dioxygenase (IDO) and tryptophan 2,3-dio

60 eprogramming was suppressed by tumor-induced indoleamine 2,3-dioxygenase (IDO) and vaccination failed

61 Small-molecule inhibitors of indoleamine 2,3-dioxygenase (IDO) are currently being tr

62 Indoleamine 2,3-dioxygenase (IDO) catalyzes the breakdow

63 Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial,

64 Tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) constitute an importan

65 aneous efficacy of serum and urine biomarker indoleamine 2,3-dioxygenase (IDO) enzyme activity and pe

66 CR analysis revealed a 5-fold enhancement of indoleamine 2,3-dioxygenase (IDO) expression in the tumo

67 Additionally, indoleamine 2,3-dioxygenase (IDO) expression was only mo

68 Indoleamine 2,3-dioxygenase (IDO) has immunoregulatory r

69 vation of the tryptophan catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) in cancer cells facili

70 ously shown that an immunomodulatory enzyme, indoleamine 2,3-dioxygenase (IDO) in dermal fibroblasts

71 rucial role for the immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) in GVHD regulation.

72 tent to express the T-cell regulatory enzyme indoleamine 2,3-dioxygenase (IDO) in mice treated with T

73 upregulated both the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) in plasmacytoid DCs an

74 critical role for the immune escape mediator indoleamine 2,3-dioxygenase (IDO) in supporting inflamma

75 Elevation of the immunomodulatory enzyme indoleamine 2,3-dioxygenase (IDO) in tumor cells can fac

76 n 4 (CTLA-4) blockade and treatment with the indoleamine 2,3-dioxygenase (IDO) inhibitor 1-methyl-D-t

77 n a prodrug conjugate of PEG with NLG919, an indoleamine 2,3-dioxygenase (IDO) inhibitor currently us

78 nt and include chemotherapeutics, radiation, indoleamine 2,3-dioxygenase (IDO) inhibitors, inhibitors

79 Indoleamine 2,3-dioxygenase (IDO) is a heme-containing d

80 Indoleamine 2,3-dioxygenase (IDO) is a heme-containing e

81 The heme enzyme indoleamine 2,3-dioxygenase (IDO) is a key regulator of

82 Indoleamine 2,3-dioxygenase (IDO) is a negative regulato

83 The immunosuppressive protein indoleamine 2,3-dioxygenase (IDO) is a rate-limiting enz

84 Indoleamine 2,3-dioxygenase (IDO) is a unique cytosolic

85 Indoleamine 2,3-dioxygenase (IDO) is an immunosuppressiv

86 bolism of the amino acid tryptophan (Trp) by indoleamine 2,3-dioxygenase (IDO) is considered an impor

87 Indoleamine 2,3-dioxygenase (IDO) is emerging as an impo

88 The immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) is expressed by a subs

89 The immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) is expressed by APCs a

90 The tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) is expressed in macrop

91 y, expression of the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO) is induced following i

92 Indoleamine 2,3-dioxygenase (IDO) is one molecular mecha

93 Indoleamine 2,3-dioxygenase (IDO) is the enzyme that cat

94 Indoleamine 2,3-dioxygenase (IDO) is the first and rate-

95 Indoleamine 2,3-dioxygenase (IDO) is the first and rate-

96 Indoleamine 2,3-dioxygenase (IDO) is the rate-limiting e

97 Here, we examine the inhibitory role of indoleamine 2,3-dioxygenase (IDO) on the antitumor effic

98 well as interfering in the immunosuppressive indoleamine 2,3-dioxygenase (IDO) pathway.

99 Tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) play a central role in

100 The heme enzyme indoleamine 2,3-dioxygenase (IDO) plays an important imm

101 ors of the tryptophan (Trp) catabolic enzyme indoleamine 2,3-dioxygenase (IDO) represent a vanguard o

102 Dendritic cell-derived indoleamine 2,3-dioxygenase (IDO) suppresses naive T cel

103 s study, we investigated the relationship of indoleamine 2,3-dioxygenase (IDO) systemic activity on c

104 The heme enzyme indoleamine 2,3-dioxygenase (IDO) was found to catalyze

105 In vivo blockade of indoleamine 2,3-dioxygenase (IDO) was performed, and its

106 In contrast, we found that the induction of indoleamine 2,3-dioxygenase (IDO) was required for the a

107 the tolerogenic tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) were analyzed using fl

108 Inflammation activates indoleamine 2,3-dioxygenase (IDO) which metabolizes tryp

109 ithelial infection by inducing expression of indoleamine 2,3-dioxygenase (IDO), a host enzyme with pr

110 sed antitumor response through inhibition of indoleamine 2,3-dioxygenase (IDO), a key tolerogenic enz

111 The expression of indoleamine 2,3-dioxygenase (IDO), a known immunosuppres

112 duct brassinin to be a moderate inhibitor of indoleamine 2,3-dioxygenase (IDO), a new cancer immunosu

113 Indoleamine 2,3-dioxygenase (IDO), a potent immunosuppre

114 Br-brassinin) are bioavailable inhibitors of indoleamine 2,3-dioxygenase (IDO), a pro-toleragenic enz

115 s to HDAC inhibitors increased expression of indoleamine 2,3-dioxygenase (IDO), a suppressor of DC fu

116 through pathogen-specific local induction of indoleamine 2,3-dioxygenase (IDO), a tryptophan cataboli

117 re treated with a pharmacologic inhibitor of indoleamine 2,3-dioxygenase (IDO), a tryptophan-cataboli

118 ad7-deficient DCs expressed higher levels of indoleamine 2,3-dioxygenase (IDO), an enzyme associated

119 at M. tuberculosis induced the expression of indoleamine 2,3-dioxygenase (IDO), an enzyme involved in

120 One ISG candidate, indoleamine 2,3-dioxygenase (IDO), an IFN-gamma-induced

121 Similar to CTLA-4 and FoxP3, expression of indoleamine 2,3-dioxygenase (IDO), an immunosuppressive

122 Indoleamine 2,3-dioxygenase (IDO), an interferon gamma-i

123 sing T cells (CARTs) through the activity of indoleamine 2,3-dioxygenase (IDO), an intracellular enzy

124 nzymes, tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO), during its conversion

125 l-molecule immunotherapy agent that inhibits indoleamine 2,3-dioxygenase (IDO), encapsulated in the n

126 yptophan catabolism, initiated by the enzyme indoleamine 2,3-dioxygenase (IDO), is a critical partici

127 Although the tryptophan-degrading enzyme, indoleamine 2,3-dioxygenase (IDO), is a pivotal mediator

128 analytes-including plasma concentrations of indoleamine 2,3-dioxygenase (IDO), KYN, kynurenic acid (

129 ted reduced toxicity as reflected by induced indoleamine 2,3-dioxygenase (IDO), suggesting discreet a

130 induce an IFNgamma-driven induction of host indoleamine 2,3-dioxygenase (IDO), the first and rate-li

131 Indoleamine 2,3-dioxygenase (IDO), the first and rate-li

132 We studied the expression of indoleamine 2,3-dioxygenase (IDO), the first enzyme in t

133 n of innate immunity, induces high levels of indoleamine 2,3-dioxygenase (IDO), the rate-limiting enz

134 Indoleamine 2,3-dioxygenase (IDO), the rate-limiting enz

135 f expressing the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO), which allows them to

136 Indoleamine 2,3-dioxygenase (IDO), which degrades trypto

137 C production of the immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO), which depletes local

138 ations of RV-PV dysfunction with circulating indoleamine 2,3-dioxygenase (IDO)-dependent tryptophan m

139 ptophan oxidation products produced from the indoleamine 2,3-dioxygenase (IDO)-mediated kynurenine pa

140 uce the tryptophan (Trp)-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO).

141 te-limiting enzyme of tryptophan catabolism, indoleamine 2,3-dioxygenase (IDO).

142 ession of the tryptophan catabolizing enzyme indoleamine 2,3-dioxygenase (IDO).

143 l expression of the immunosuppressive enzyme indoleamine 2,3-dioxygenase (Ido).

144 s) up-regulate the immune-inhibitory enzyme, indoleamine 2,3-dioxygenase (IDO).

145 s a key pharmacophore in novel inhibitors of indoleamine 2,3-dioxygenase (IDO).

146 family of homologous enzymes, which includes indoleamine 2,3-dioxygenase (IDO).

147 LNs can express the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO).

148 his tolerance is the immunoregulatory enzyme indoleamine 2,3-dioxygenase (IDO).

149 essed immunosuppressive levels of the enzyme indoleamine 2,3-dioxygenase (IDO).

150 expression of tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase (IDO).

151 in RA patients partly via the production of indoleamine 2,3-dioxygenase (IDO).

152 use tryptophan-catabolizing enzymes such as indoleamine 2,3-dioxygenase (IDO-1) to induce an immunos

153 Furthermore, while indoleamine 2,3-dioxygenase (IDO1) drives AhR activation

154 ession of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase (IDO1) in human epithelial c

155 Indoleamine 2,3-dioxygenase (IDO1) inhibitors are specul

156 Indoleamine 2,3-dioxygenase (IDO1) is a heme enzyme that

157 Indoleamine 2,3-dioxygenase (IDO1) is a tryptophan (Trp)

158 Tryptophan catabolism mediated by indoleamine 2,3-dioxygenase (IDO1) is an important mecha

159 he anti-inflammatory and anti-bacterial gene indoleamine 2,3-dioxygenase (IDO1) is dependent on STAT1

160 Human indoleamine 2,3-dioxygenase 1 (hIDO1) and human tryptoph

161 Indoleamine 2,3-dioxygenase 1 (hIDO1) and tryptophan dio

162 Human indoleamine 2,3-dioxygenase 1 (hIDO1) is an attractive c

163 Since the discovery of indoleamine 2,3-dioxygenase 1 (IDO1) as an attractive ta

164 ses of two antiretroviral ISGs indicate that indoleamine 2,3-dioxygenase 1 (IDO1) can inhibit retrovi

165 Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the rate-

166 as driven by IFN-gamma-mediated induction of indoleamine 2,3-dioxygenase 1 (IDO1) enzyme activity wit

167 ession of the tryptophan metabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1) in the intestinal e

168 Indoleamine 2,3-dioxygenase 1 (IDO1) is a key regulatory

169 Indoleamine 2,3-dioxygenase 1 (IDO1) is a single chain o

170 Indoleamine 2,3-dioxygenase 1 (IDO1) is an important the

171 ding l-kynurenine (Kyn), the main product of indoleamine 2,3-dioxygenase 1 (IDO1) that catalyzes the

172 d that S. flexneri induces the expression of indoleamine 2,3-dioxygenase 1 (IDO1) through the nucleot

173 Here, we report that brain indoleamine 2,3-dioxygenase 1 (IDO1), a rate-limiting en

174 tion, a host tryptophan-catabolizing enzyme, indoleamine 2,3-dioxygenase 1 (IDO1), is induced specifi

175 Indoleamine 2,3-dioxygenase 1 (IDO1), promoting immune e

176 s along the kynurenine pathway by the enzyme indoleamine 2,3-dioxygenase 1 (IDO1), which is induced b

177 ystemic inflammation only in the presence of indoleamine 2,3-dioxygenase 1 (IDO1).

178 oxP3(+) regulatory T-cells (Tregs), CD47 and indoleamine 2,3-dioxygenase 1 (IDO1).

179 ndoles are described as potent inhibitors of indoleamine 2,3-dioxygenase 1 (IDO1).

180 asmid against the immunosuppressive molecule indoleamine 2,3-dioxygenase 1 (shIDO).

181 Tryptophan catabolism by the enzymes indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxyge

182 hermore, treatment of NKp44(+) NK cells with indoleamine 2,3-dioxygenase 1 catabolites in vitro ablat

183 However, whether indoleamine 2,3-dioxygenase 1 forms (1)O(2) and whether

184 Here we show that arterial indoleamine 2,3-dioxygenase 1 regulates blood pressure v

185 lysed by a family of dioxygenases, including indoleamine 2,3-dioxygenase 1(5).

186 Indoleamine 2,3-dioxygenase 1, a catabolic enzyme, and i

187 inflammatory mediators in the gut, including indoleamine 2,3-dioxygenase 1.

188 Increased indoleamine 2,3-dioxygenase activity and consequent indu

189 cts of gamma interferon (IFN-gamma)-mediated indoleamine 2,3-dioxygenase activity on C. pneumoniae pe

190 The indoleamine 2,3-dioxygenase activity was assessed by mas

191 lls express high levels of CD163, CD206, and indoleamine 2,3-dioxygenase and secrete immunosuppressiv

192 grafts and increased expression of mRNAs for indoleamine 2,3-dioxygenase and the subunits encoding in

193 is an O2-dependent process and catalyzed by indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygena

194 With TDO and Indoleamine 2,3-dioxygenase as evolutionarily conserved

195 Inhibition of placental indoleamine 2,3-dioxygenase by 1-methyl-tryptophan preve

196 Indoleamine 2,3-dioxygenase catalyzes the O(2)-dependent

197 IL-27-induced indoleamine 2,3-dioxygenase enzymatic activity leads to

198 but not sequence homology to the two-domain indoleamine 2,3-dioxygenase enzyme (IDO).

199 on an omega-3 fatty acid derivative inducing indoleamine 2,3-dioxygenase expression in DC.

200 In human epithelial cells, IFN-gamma induces indoleamine 2,3-dioxygenase expression that inhibits chl

201 feron-gamma, which increases villous explant indoleamine 2,3-dioxygenase expression, has no effect on

202 ve increased accumulation of CD11c cells and indoleamine 2,3-dioxygenase expression.

203 f AhR ligands by microbiota that could limit indoleamine 2,3-dioxygenase induction and influence allo

204 ally sensitive to immunopharmacotherapy with indoleamine 2,3-dioxygenase inhibitors.

205 Abnormal tryptophan metabolism catalyzed by indoleamine 2,3-dioxygenase may play a prominent role in

206 rs such as TGF-beta, CTLA-4, PD-1, ICOS, and indoleamine 2,3-dioxygenase play an important role in im

207 Indoleamine 2,3-dioxygenase plays a key role in local tr

208 FN-gamma synthesis by donor T cells inducing indoleamine 2,3-dioxygenase synthesis by donor pDCs limi

209 ending on IFNgamma signaling and mediated by indoleamine 2,3-dioxygenase to a constitutive mechanism

210 leged media, which related to A20 preventing indoleamine 2,3-dioxygenase upregulation in SMC.

211 Indoleamine 2,3-dioxygenase was expressed on background

212 explants was markedly reduced when placental indoleamine 2,3-dioxygenase was stimulated with interfer

213 a number of suppressive enzymes, among which indoleamine 2,3-dioxygenase was sufficient to inhibit an

214 ic cell accumulation, expression of IL-2 and indoleamine 2,3-dioxygenase were evident in TLR4 compare

215 n (which is a known competitive inhibitor of indoleamine 2,3-dioxygenase) is a competitive inhibitor

216 ence of interferon-gamma (known to stimulate indoleamine 2,3-dioxygenase) tryptophan but not threonin

217 also inhibited PIV3, including IFITM1, IDO (indoleamine 2,3-dioxygenase), PKR (protein kinase, RNA a

218 r- beta 1+ cells, interleukin-10+ cells, and indoleamine 2,3-dioxygenase+CD3+ cells.

219 n-gamma-induced degradation of tryptophan by indoleamine 2,3-dioxygenase, activates the previously or

220 e, is similar to that of the large domain of indoleamine 2,3-dioxygenase, an enzyme that catalyzes th

221 g induction was mediated by DC expression of indoleamine 2,3-dioxygenase, and was confirmed in IDO-KO

222 Potential roles for indoleamine 2,3-dioxygenase, costimulatory molecules, an

223 We measured indoleamine 2,3-dioxygenase, interleukin-6, and transfor

224 ed during tryptophan metabolism initiated by indoleamine 2,3-dioxygenase, is known to induce T cell d

225 ane vesicles as part of a study on placental indoleamine 2,3-dioxygenase, the L-tryptophan-catabolisi

226 ophan limitation mediated by the host enzyme indoleamine 2,3-dioxygenase, which converts l-tryptophan

227 and primarily dependent on pDC expression of indoleamine 2,3-dioxygenase, which was induced through t

228 munodeficiency virus (HIV) infection-induced indoleamine 2,3-dioxygenase-1 (IDO) expression in activa

229 Small-molecule inhibitors of indoleamine 2,3-dioxygenase-1 (IDO1) are emerging at the

230 We report the discovery of a novel indoleamine 2,3-dioxygenase-1 (IDO1) inhibitor class thr

231 Indoleamine 2,3-dioxygenase-1 (IDO1; IDO) mediates oxida

232 ols, whereas level of messenger RNA encoding indoleamine 2,3-dioxygenase-1 was significantly increase

233 sistent with a common reaction mechanism for indoleamine 2,3-dioxygenase-catalyzed oxidation of trypt

234 ance of L-tryptophan transport for placental indoleamine 2,3-dioxygenase-mediated degradation of L-tr

235 nts both BCH and 1-methyl-tryptophan inhibit indoleamine 2,3-dioxygenase-mediated L-tryptophan degrad

236 e trophoblast to be a rate-limiting step for indoleamine 2,3-dioxygenase-mediated L-tryptophan degrad

237 his mechanism is dependent both on placental indoleamine 2,3-dioxygenase-mediated tryptophan degradat

238 cyte division was specifically suppressed by indoleamine 2,3-dioxygenase-mediated tryptophan depletio

239 were evaluated for their ability to inhibit indoleamine 2,3-dioxygenase.

240 the presence of H(2)O(2)/ONOO(-) deactivated indoleamine 2,3-dioxygenase.

241 of 2',5'-oligoadenylate synthetase, Mx1, and indoleamine 2,3-dioxygenase.

242 cells through the induction and activity of indoleamine 2,3-dioxygenase.

243 a induces expression of p47 GTPases, but not indoleamine 2,3-dioxygenase.

244 hyl-tryptophan which is also an inhibitor of indoleamine 2,3-dioxygenase.

245 t in vitro (though not in vivo) inhibitor of indoleamine 2,3-dioxygenase.

246 eam target, the tryptophan-catalyzing enzyme indoleamine 2,3-dioxygenase.

247 eries of substituted tryptophan analogues by indoleamine 2,3-dioxygenase.

248 including those combining PD1 blockade with indoleamine 2,3-dioxygenase/tryptophan 2,3-dioxygenase (

249 of various tumor-promoting genes, including indoleamine 2,3-dioxygenase; and attenuation of these ch

250 uman (hIDO) and Shewanella oneidensis (sIDO) indoleamine 2,3-dioxygenases, Xanthomonas campestris (Xc

251 oring of tryptophan (trp) metabolism through indoleamine 2.3-dioxygenase (IDO) has been previously pr

252 FN-gamma, which stimulated the expression of indoleamine-2,3-dioxegenase (IDO) 1, an immune regulator

253 levels of immune-inhibitory IL-10, IL12p40, indoleamine-2,3-dioxidase, and TIMP-1 (tissue inhibitor

254 proved SB transposon encoding the human gene indoleamine-2,3-dioxygenase (hIDO), an enzyme that posse

255 uced inducible nitric oxide synthase (iNOS), indoleamine-2,3-dioxygenase (IDO) and heme oxygenase (HO

256 Indoleamine-2,3-dioxygenase (IDO) and tryptophanyl-tRNA-

257 Expression of indoleamine-2,3-dioxygenase (IDO) by vascular endotheliu

258 The enzyme indoleamine-2,3-dioxygenase (IDO) catalyses degradation

259 t levo-1-methyl tryptophan (L-1MT) can block indoleamine-2,3-dioxygenase (IDO) expressed by human den

260 the tumor tissue by the rate-limiting enzyme indoleamine-2,3-dioxygenase (IDO) expressed in tumor cel

261 yptophan pools by gamma interferon-inducible indoleamine-2,3-dioxygenase (IDO) is believed to be the

262 ryptophan and kynurenine, metabolites of the indoleamine-2,3-dioxygenase (IDO) pathway.

263 roids augment MSC expression and activity of indoleamine-2,3-dioxygenase (IDO), a primary mediator of

264 Expression of indoleamine-2,3-dioxygenase (IDO), an immunosuppressive

265 m the induction of type I IFN-alpha/beta and indoleamine-2,3-dioxygenase (IDO)-mediated immunosuppres

266 ting environment via induction of the enzyme indoleamine-2,3-dioxygenase (IDO).

267 ibitor of the tryptophan catabolizing enzyme indoleamine-2,3-dioxygenase (IDO).

268 ential target as the immunoregulatory enzyme indoleamine-2,3-dioxygenase (IDO).

269 al burdens than control mice, underexpressed indoleamine-2,3-dioxygenase (Ido1) in lung endothelium a

270 in the promoter region of the gene encoding indoleamine-2,3-dioxygenase (IDO1) was found to be assoc

271 we show that untreated PDACs express minimal indoleamine-2,3-dioxygenase (IDO1); however, GVAX therap

272 cells, possibly via stimulation of host cell indoleamine-2,3-dioxygenase activity, in a dose-dependen

273 ot reverse tolerance, but treatment with the indoleamine-2,3-dioxygenase antagonist 1-methyltryptopha

274 ne (l-Kyn), which is supplied by a dedicated indoleamine-2,3-dioxygenase NanC encoded in the gene clu

275 w) phenotype, expressed the immunomodulatory indoleamine-2,3-dioxygenase, and upregulated expression

276 expression of tolerogenic mediators, such as indoleamine-2,3-dioxygenase, arginase, and TGF-beta, and

277 tor-kappaB, as well as the metabolic enzyme, indoleamine-2,3-dioxygenase, which breaks down tryptopha

278 Elevated betaDG correlated positively with indoleamine-2,3-dioxygenase-1 enzyme activity, regulator

279 ited T-cell reactivity through regulation of indoleamine-2,3-dioxygenase.

280 ulatory molecules including IL-10, CD25, and indoleamine-2,3-dioxygenase.

281 xpression of the tryptophan-degrading enzyme indoleamine-2,3-dioxygenase.

282 results demonstrate a role for induction of indoleamine-2,3dioxygenase in accelerating the local for

283 This study evaluates a series of indoleamine analogs as alternate substrates of AANAT.

284 nicotinamide adenine dinucleotide, retinol, indoleamines, and collagen provides crucial information

285 oxyl radicals exceeded that of melatonin, an indoleamine considered to be the most potent naturally o

286 enase involved in the degradation of several indoleamine derivatives and has been indicated as an imm

287 Gamma interferon (IFN-gamma)-induced indoleamine dioxygenase (IDO), which inhibits chlamydial

288 ssive molecules such as TGF-beta, IL-10, and indoleamine dioxygenase (IDO).

289 ve focused on three enzymes in this pathway: indoleamine dioxygenase (IDO1), kynurenine monooxygenase

290 was microbistatic but was independent of 2,3-indoleamine dioxygenase activity.

291 are involved in the synergistic induction of indoleamine dioxygenase in epithelial cells.

292 The role of the indoleamine melatonin in seasonal adaptations in birds h

293 actor in the production of catecholamine and indoleamine neurotransmitters and is also essential for

294 mediated T-cell proliferation, primarily via indoleamine oxidase (IDO).

295 methyl-D-tryptophan, a specific inhibitor of indoleamine-pyrrole 2,3-dioxygenase (IDO), but not by NS

296 xidase subunits (p47(phox) or gp91(phox)) or indoleamine-pyrrole 2,3-dioxygenase 1 with or without an

297 mice deficient for p47(phox), gp91(phox), or indoleamine-pyrrole 2,3-dioxygenase 1, suggesting that A

298 , AngII markedly increased the expression of indoleamine-pyrrole 2,3-dioxygenase in parallel with inc

299 se systems, sometimes in comparison with the indoleamine serotonin (5-HT), on performance on a variet

300 amines (norepinephrine and dopamine) and the indoleamine serotonin (5-HT).