ライフサイエンスコーパス: induced Treg

1 y by the conversion of naive CD4(+) T cells (induced Tregs).

2 Furthermore, unpulsed mDC, but not iDC, also induced Treg.

3 ing in differentiation of naive T cells into induced Treg.

4 STAT6 limits both naturally occurring and Ag-induced Tregs.

5 is process contributes to the development of induced Tregs.

6 on of CD8+ T cells by Friend retrovirus (FV)-induced Tregs.

7 s mainly through maintaining survival of the induced Tregs.

8 n the lung, and with M. tuberculosis antigen-induced Tregs.

9 oth peripherally derived iTregs and in vitro-induced Tregs.

10 e dependent on TGF-ss, indicating a role for induced Tregs.

11 gene and the suppressive function of sorted induced Tregs.

12 ventional CD4(+) T cells that converted into induced Tregs.

13 ppression could also be mediated by Foxp3(+)-induced Tregs.

14 e B mRNA (P<0.01) were higher in alloantigen-induced Tregs (alloTregs) compared with nTregs.

15 staining Foxp3-transcriptional activation in induced Tregs also promotes CNS2 demethylation, enhancin

16 D4+ Tregs induced from CD4+CD25- precursors (induced Tregs) also regulate immune responses in the per

17 tion and proliferation while reducing sepsis-induced Treg and MDSC expansion.

18 a and Foxp3 to the transcriptome of TGF-beta-induced Treg and showed that TGF-beta elicited a large s

19 CXCR3 antagonist AMG487 attenuated PEO4 cell-induced Tregs and decreased IL10 production.

20 teral administration of retinoic acid, which induced Tregs and decreased NEC severity.

21 ammat(+) CD4 T cells, including peripherally-induced Tregs and IL17-producing (Th17) T cells.

22 wledge, we show for the first time that both induced Tregs and natural Tregs (nTregs) increase their

23 with UVB phototherapy showed an increase in induced Tregs and tolerogenic DCs accompanied by the dow

24 These data demonstrate that natural and not induced Tregs are less suppressive in patients with mult

25 unction) at levels similar to soluble factor induced Treg as well as naturally occurring Treg.

26 d for the proper differentiation of in vitro-induced Tregs as well as maintenance of Tregs.

27 Antibodies to LAG-3 inhibit suppression by induced Tregs both in vitro and in vivo.

28 unlike oral administration of antigen, which induced Tregs but not effector T cells, i.p. immunizatio

29 We also show that pDC-induced Tregs can inhibit conventional DC (cDC) maturati

30 gfDNA limited lamina propria dendritic cell-induced Treg cell conversion in vitro.

31 whereas adoptive transfer of tolerized pDCs induced Treg cell development and prolonged graft surviv

32 tory environments was perturbed and TGF-beta-induced Treg cell development was reduced.

33 epithelial-mesenchymal transition, TGF-beta-induced Treg cell differentiation upon virus infection,

34 deficiency in TAZ or overexpression of TEAD1 induced Treg cell differentiation, whereas expression of

35 IL-13, and IFN-gamma, upregulated IL-10, and induced Treg cell production.

36 promoted in vivo expansion of Treg cells and induced Treg cell-dependent immune tolerance by suppress

37 Therefore, ATRA treatment induced Treg cell-dependent immune tolerance by suppress

38 we determined whether AREG has a role in UVB-induced, Treg cell-mediated suppression of CHS reactions

39 SC) as being critical for the development of induced Treg cells (iTreg cells) by repression of the T

40 ng the conversion of CD4(+) Tconv cells into induced Treg cells (iTreg cells).

41 51 peptide can be converted into CD25+Foxp3+ induced Treg cells (iTregs) when stimulated in the prese

42 g, to OVA-sensitized and OVA-challenged mice induced Treg cells and attenuated airway hyperresponsive

43 ely transferred to mice before OVA challenge induced Treg cells and inhibited AHR.

44 eceptor repertoires of thymic Treg cells and induced Treg cells are biased towards self and non-self

45 indings suggest that peripheral expansion of induced Treg cells can serve as a promising therapeutic

46 HLA-DR1-induced Treg cells confer resistance to disease in HLA-D

47 reg differentiation, TSLP receptor-deficient induced Treg cells derived from naive CD4(+) T cells are

48 This early production of IFNgamma by induced Treg cells during an immune response can directl

49 The induced Treg cells home specifically to the lungs and dr

50 is indispensable for the differentiation of induced Treg cells in vitro and Treg cell mitochondrial

51 mma produced rapidly and only transiently by induced Treg cells is crucial to their function in vivo.

52 Finally, Dll4-exposed induced Treg cells maintained the CD62L(hi)CD44(lo) cent

53 Mechanistically, TSLP activates induced Treg cells partially through mTORC1 activation a

54 ed alpha-melanocyte stimulated hormone (MSH)-induced Treg cells specific to ocular autoantigen suppre

55 The induced Treg cells suppress nuclear autoantigen-specific

56 nal approach, we then demonstrate that human induced Treg cells suppress syngeneic human ILC2s throug

57 Vaccine-induced Treg cells thus play a crucial role in the contr

58 tly, perturbations in the differentiation of induced Treg cells was linked to a fatal Th2-type chroni

59 thymic emigrants and the differentiation of induced Treg cells were normal, LRBA-deficient T cells e

60 ells have been reported as a novel subset of induced Treg cells with modulatory characteristics.

61 TGF-beta(+)CD4(+)CD25(+) regulatory T cells (induced Treg cells).

62 y cells, converted naive CD4(+) T cells into induced Treg cells, and presented antigen by an unusual

63 We show that induced Treg cells, but not natural Treg cells, effectiv

64 ults suggest that thymic Treg cells, and not induced Treg cells, dominantly mediate tolerance to anti

65 icantly increased in the presence of antigen-induced Treg cells, while their proliferation remains un

66 tigen) or ovalbumin (OVA)-specific alpha-MSH-induced Treg cells.

67 development but is not expressed on TGF-beta-induced Treg cells.

68 ntration in the peripheral lymphoid tissues, induced Treg cells.

69 ability of both thymically- and peripherally-induced Treg cells.

70 l homeostasis depends on microbiota-specific induced Treg cells.

71 Foxp3 to normal amounts in natural, but not induced, Treg cells.

72 anced levels of Tregs, suggesting that 3-HAA-induced Tregs contribute to inhibition of Th17 cells.

73 ation was not required for suppression by FV-induced Tregs, correlating with their high activation st

74 erating a robust antitumor CTL response, but induced Tregs could be.

75 103(+) dendritic cells, such as peripherally induced Treg development or imprinting CCR9 and alpha4be

76 dings suggest a role for GARP in natural and induced Treg development through activation of bound lat

77 with recombinant Dll4 inhibits the TGF-beta-induced Treg development, and inhibits Janus kinase 3-in

78 nuclear translocation and inhibited TGF-beta-induced Treg development.

79 committed Th1 polarization blocks pregnancy induced Treg differentiation among maternal CD4(+) T cel

80 failed to provide TGF-beta1 to drive Th17 or induced Treg differentiation in vitro.

81 with Ex-527 promotes Foxp3 expression during induced Treg differentiation, enhances Foxp3 levels in n

82 DC-induced Treg division required IL-2, which was provided

83 g, and Ag-expressing B cells from these mice induced Treg division without upregulation of CXCR3.

84 Ld-IL-2 induced Treg expansion and activation that elicited prot

85 neutralizing anti-ICOS antibody blocked pDC-induced Treg expansion and interleukin-10 secretion by m

86 onclusion, these results indicate that IL-2C-induced Treg expansion attenuates acute renal damage and

87 L-2C administered before bilateral renal IRI induced Treg expansion in both spleen and kidney, improv

88 grated to the secondary lymphoid tissues and induced Treg expansion in lymph nodes.

89 Conversely, IL-2 complex-induced Treg expansion in wild-type mice with establishe

90 efficiently suppressed effector T cells and induced Treg expansion through the cAMP response element

91 eg proliferation in vitro, while in vivo ICI-induced Treg expansion was fully abrogated by FGFR inhib

92 ependent AT-II cells were isolated from IDLA-induced Treg expansion.

93 uced by them play an essential role in tumor-induced Treg expansion.

94 molecules and studied their effects on tumor-induced Treg expansion.

95 ted role for FGFR inhibition in blocking ICI-induced Treg expansion.

96 - and Jagged1-induced cosignaling in GM-BMDC-induced Treg expansion.

97 t allograft model, T-bet(-/-) nTreg, but not induced Treg, failed to prolong graft survival as effect

98 We also show that IFNgamma-induced Treg fragility is required for response to anti-

99 lls had a reduced ability in T-cell receptor-induced Treg generation (p = 0.002 vs. SA; p = 0.001 vs.

100 inhibition of RAR signaling augmented donor-induced Treg generation and expansion in vivo, while pre

101 lular mechanism or mechanisms underlying PDC-induced Treg generation are unknown.

102 r differentiation efficiently and to promote induced Treg generation of non-Treg cells lacking both S

103 affiliation with naturally occurring Treg or induced Treg in the circulating Treg pool.

104 vated CD4(+) T cells, and peripheral TGFbeta-induced Treg in which it was bound by DNMT1, DNMT3b, MeC

105 ating the effects of islet-specific TGF-beta-induced Tregs in recipient mice in which the Treg Ag is

106 During AAD, T+P-induced Tregs in the lungs displayed a highly suppressiv

107 ide impaired effector T cell conversion into induced Tregs in the presence of TGF-beta.

108 and rapamycin is requisite for Flt3L/antigen-induced Treg induction because Flt3L/antigen by itself f

109 ulator for opening up the CNS2 region during induced Treg induction, whereas AP-1 and Creb maintain E

110 In vitro IFN-beta + MOG-induced Tregs inhibited EAE when transferred into active

111 Adoptive transfer of induced Tregs into DC-Tgfbr2 KO mice partially rescued t

112 DC maturation by complement/CD46-induced Tregs is mediated through simultaneous secretion

113 involved in the differentiation of TH17 and induced Tregs, is instead expressed in Helios(-) Tregs.

114 el strategies to generate bona fide in vitro-induced Treg (iTreg) are critical.

115 Indeed, the generation of peripherally induced Treg (iTreg) by TGF-beta was highly dependent on

116 natural Treg (nTreg) cells and inhibition of induced Treg (iTreg) cell polarization from naive CD4(+)

117 a chain (Il4ra(R576)) promotes conversion of induced Treg (iTreg) cells toward a T helper 17 (TH17) c

118 ansfer of either nTreg or polyclonal TGFbeta-induced Treg (iTreg) did not prevent AIG, while cotransf

119 tural Treg stably express Foxp3, adaptive or induced Treg (iTreg) generated from peripheral CD4 T cel

120 erentiated into Bet-specific or non-specific induced Treg (iTreg).

121 can be induced from non-Treg CD4(+) T cells (induced Treg [iTreg] cells) by TCR triggering, IL-2, and

122 orming growth factor beta (TGFbeta) ex vivo (induced Treg [iTreg] cells) to the effects of equivalent

123 In this study, we report that TGF-beta-induced Tregs (iTregs) and expanded Tregs specific for a

124 ternative approaches to generate Ag-specific induced Tregs (iTregs) and tested their efficacy and sel

125 DC function in a model in which Ag-specific, induced Tregs (iTregs) are cocultured with DCs in the ab

126 28 costimulation regulates the generation of induced Tregs (iTregs) from naive CD4 T-cell precursors

127 TGFbeta-induced Tregs (iTregs) have all the characteristics of n

128 ression on murine natural Tregs (nTregs) and induced Tregs (iTregs) in mediating suppression of colit

129 cantly greater than that observed for CD4(+)-induced Tregs (iTregs) in nearly all tissue sites.

130 miR-29a impacted the production of in vitro-induced Tregs (iTregs) in overexpression and blocking ex

131 s any role during the generation of TGF-beta-induced Tregs (iTregs) is unknown.

132 he thymus, increasing evidence suggests that induced Tregs (iTregs) may be generated in the periphery

133 egs (nTregs) that develop in the thymus, and induced Tregs (iTregs) that differentiate in peripheral

134 Lastly, in vitro-generated induced Tregs (iTregs) were shown to be highly plastic a

135 natural regulatory T cells (nTregs), CD4(+) induced Tregs (iTregs), and CD8(+) iTregs, and was more

136 reveals that a group of regulatory T cells, induced Tregs (iTregs), effectively suppress the product

137 ated the effect of pembrolizumab on in vitro-induced Tregs (iTregs).

138 main Treg subsets, thymus-derived Tregs and induced Tregs (iTregs).

139 s [and their ex vivo generated counterparts, induced Tregs (iTregs)] offer particular therapeutic pot

140 tion consistent with an uncommitted in vitro-induced Treg-like phenotype.

141 ival beyond day 30; and 6) corneal allograft-induced Treg-mediated suppression is transient.

142 These data suggest that CD46-induced Tregs might play a role in intestinal immune hom

143 d T-bet(-/-) CD4(+) conventional T cells and induced Treg migrated normally toward afferent lymphatic

144 CCL22 + SC-islets induced Treg migration in vitro, with specificity to CCL

145 Moreover, MAPC cell-induced Tregs (miTregs) have a more suppressive phenotyp

146 Thus, suppression of CD8(+) T cells by virus-induced Tregs occurs in a tissue-specific manner and cor

147 our results reveal that EOC leverages CXCL10-induced Tregs or adenosine signaling to dampen T cell-me

148 Exogenous hemin induced Treg polarization in purified T cell/monocyte co

149 but significantly blocked alpha-(1,3)-glucan-induced Treg polarization.

150 Thus, CD46-induced Tregs produce a distinct cytokine profile that i

151 PKC-(-/-) mice were also defective in G-BMDC induced Treg proliferation ex vivo, this defect could be

152 TNFR25-induced Treg proliferation was dependent upon TCR engage

153 By contrast, HSCs induced Treg proliferation, which required cell-cell con

154 th self-MHC class II is not required for PMA-induced Treg proliferation.

155 by cognate Ag/MHC II complexes enhanced IL-2-induced Treg proliferation.

156 t an IL-12-IFN-gamma axis can suppress tumor-induced Treg proliferation.

157 ural Tregs (tTregs) and peripherally-derived induced Tregs (pTregs).

158 sed the proportion of motile Tregs, and also induced Treg recruitment.

159 The VIP/DC-induced Treg resemble the previously described Tr1 in te

160 Aza plus TGFbeta-induced Treg resembled nTreg, expressing similar recepto

161 xtraintestinal tissues, whereas peripherally induced Tregs retained in the absence of B7 selectively

162 DC-induced Treg's from both healthy donors and patients wit

163 otyping and gene profiling reveal that BTNL2-induced Treg share many properties with natural Treg, an

164 that human Helios(-) memory Tregs encompass induced Tregs that can readily respond to changes in the

165 The TGF-beta-induced Tregs that express IL-10 blocked colitis when tr

166 pithelium-adapted CD4+ T cells and tolerance-induced Tregs that recognize dietary antigens, suggestin

167 -experienced Tconv converting into secondary induced Treg through intratumoral activation.

168 hus, TSLP modulates the activation status of induced Treg through the enhanced uptake of fatty acids

169 Moreover, the ability of induced Treg to control airway hyperreactivity and effec

170 DCs acted as a pivotal molecular switch that induced Tregs to acquire a stable suppressor phenotype,

171 timulatory self-peptide expressed by B cells induced Tregs to proliferate without acquiring an effect

172 fied by RNA sequencing analysis of the DEL-1-induced Treg transcriptome.

173 whether FOXP3 expression in 1,25(OH)(2)VD(3)-induced Treg (VD-iTreg) cells is critical for the inhibi

174 confirmed the deleterious effect of rapalogs-induced Tregs via a mechanism involving the inhibition o

175 Most interestingly, FV-induced Tregs were able to suppress the function of CD8+

176 T3P + Ply-induced Tregs were essential for the suppression of NKT

177 Microglia-induced Tregs were functionally active in vitro by inhib

178 nal T cells, promoting their conversion into induced Tregs with increased TSDR demethylation, enhance