ライフサイエンスコーパス: induced Treg

1 fied by RNA sequencing analysis of the DEL-1-induced Treg transcriptome.

2 Ld-IL-2 induced Treg expansion and activation that elicited prot

3 by cognate Ag/MHC II complexes enhanced IL-2-induced Treg proliferation.

4 onclusion, these results indicate that IL-2C-induced Treg expansion attenuates acute renal damage and

5 whether FOXP3 expression in 1,25(OH)(2)VD(3)-induced Treg (VD-iTreg) cells is critical for the inhibi

6 Mechanistically, TSLP activates induced Treg cells partially through mTORC1 activation a

7 STAT6 limits both naturally occurring and Ag-induced Tregs.

8 e B mRNA (P<0.01) were higher in alloantigen-induced Tregs (alloTregs) compared with nTregs.

9 ival beyond day 30; and 6) corneal allograft-induced Treg-mediated suppression is transient.

10 sed the proportion of motile Tregs, and also induced Treg recruitment.

11 Furthermore, unpulsed mDC, but not iDC, also induced Treg.

12 IL-13, and IFN-gamma, upregulated IL-10, and induced Treg cell production.

13 promoted in vivo expansion of Treg cells and induced Treg cell-dependent immune tolerance by suppress

14 eceptor repertoires of thymic Treg cells and induced Treg cells are biased towards self and non-self

15 efficiently suppressed effector T cells and induced Treg expansion through the cAMP response element

16 d T-bet(-/-) CD4(+) conventional T cells and induced Treg migrated normally toward afferent lymphatic

17 dings suggest a role for GARP in natural and induced Treg development through activation of bound lat

18 grated to the secondary lymphoid tissues and induced Treg expansion in lymph nodes.

19 ression on murine natural Tregs (nTregs) and induced Tregs (iTregs) in mediating suppression of colit

20 involved in the differentiation of TH17 and induced Tregs, is instead expressed in Helios(-) Tregs.

21 egs (nTregs) that develop in the thymus, and induced Tregs (iTregs) that differentiate in peripheral

22 main Treg subsets, thymus-derived Tregs and induced Tregs (iTregs).

23 and rapamycin is requisite for Flt3L/antigen-induced Treg induction because Flt3L/antigen by itself f

24 icantly increased in the presence of antigen-induced Treg cells, while their proliferation remains un

25 n the lung, and with M. tuberculosis antigen-induced Tregs.

26 a and Foxp3 to the transcriptome of TGF-beta-induced Treg and showed that TGF-beta elicited a large s

27 tory environments was perturbed and TGF-beta-induced Treg cell development was reduced.

28 epithelial-mesenchymal transition, TGF-beta-induced Treg cell differentiation upon virus infection,

29 development but is not expressed on TGF-beta-induced Treg cells.

30 with recombinant Dll4 inhibits the TGF-beta-induced Treg development, and inhibits Janus kinase 3-in

31 nuclear translocation and inhibited TGF-beta-induced Treg development.

32 In this study, we report that TGF-beta-induced Tregs (iTregs) and expanded Tregs specific for a

33 s any role during the generation of TGF-beta-induced Tregs (iTregs) is unknown.

34 ating the effects of islet-specific TGF-beta-induced Tregs in recipient mice in which the Treg Ag is

35 The TGF-beta-induced Tregs that express IL-10 blocked colitis when tr

36 PKC-(-/-) mice were also defective in G-BMDC induced Treg proliferation ex vivo, this defect could be

37 - and Jagged1-induced cosignaling in GM-BMDC-induced Treg expansion.

38 wledge, we show for the first time that both induced Tregs and natural Tregs (nTregs) increase their

39 otyping and gene profiling reveal that BTNL2-induced Treg share many properties with natural Treg, an

40 erating a robust antitumor CTL response, but induced Tregs could be.

41 This early production of IFNgamma by induced Treg cells during an immune response can directl

42 mma produced rapidly and only transiently by induced Treg cells is crucial to their function in vivo.

43 Antibodies to LAG-3 inhibit suppression by induced Tregs both in vitro and in vivo.

44 natural regulatory T cells (nTregs), CD4(+) induced Tregs (iTregs), and CD8(+) iTregs, and was more

45 cantly greater than that observed for CD4(+)-induced Tregs (iTregs) in nearly all tissue sites.

46 DC maturation by complement/CD46-induced Tregs is mediated through simultaneous secretion

47 These data suggest that CD46-induced Tregs might play a role in intestinal immune hom

48 Thus, CD46-induced Tregs produce a distinct cytokine profile that i

49 gfDNA limited lamina propria dendritic cell-induced Treg cell conversion in vitro.

50 Moreover, MAPC cell-induced Tregs (miTregs) have a more suppressive phenotyp

51 CXCR3 antagonist AMG487 attenuated PEO4 cell-induced Tregs and decreased IL10 production.

52 timulatory self-peptide expressed by B cells induced Tregs to proliferate without acquiring an effect

53 can be induced from non-Treg CD4(+) T cells (induced Treg [iTreg] cells) by TCR triggering, IL-2, and

54 TGF-beta(+)CD4(+)CD25(+) regulatory T cells (induced Treg cells).

55 y by the conversion of naive CD4(+) T cells (induced Tregs).

56 reveals that a group of regulatory T cells, induced Tregs (iTregs), effectively suppress the product

57 ely transferred to mice before OVA challenge induced Treg cells and inhibited AHR.

58 Conversely, IL-2 complex-induced Treg expansion in wild-type mice with establishe

59 s [and their ex vivo generated counterparts, induced Tregs (iTregs)] offer particular therapeutic pot

60 our results reveal that EOC leverages CXCL10-induced Tregs or adenosine signaling to dampen T cell-me

61 DC-induced Treg division required IL-2, which was provided

62 DC-induced Treg's from both healthy donors and patients wit

63 The VIP/DC-induced Treg resemble the previously described Tr1 in te

64 reg differentiation, TSLP receptor-deficient induced Treg cells derived from naive CD4(+) T cells are

65 ural Tregs (tTregs) and peripherally-derived induced Tregs (pTregs).

66 inhibition of RAR signaling augmented donor-induced Treg generation and expansion in vivo, while pre

67 HLA-DR1-induced Treg cells confer resistance to disease in HLA-D

68 with Ex-527 promotes Foxp3 expression during induced Treg differentiation, enhances Foxp3 levels in n

69 ulator for opening up the CNS2 region during induced Treg induction, whereas AP-1 and Creb maintain E

70 that human Helios(-) memory Tregs encompass induced Tregs that can readily respond to changes in the

71 Finally, Dll4-exposed induced Treg cells maintained the CD62L(hi)CD44(lo) cent

72 unction) at levels similar to soluble factor induced Treg as well as naturally occurring Treg.

73 e dependent on TGF-ss, indicating a role for induced Tregs.

74 ppression could also be mediated by Foxp3(+)-induced Tregs.

75 51 peptide can be converted into CD25+Foxp3+ induced Treg cells (iTregs) when stimulated in the prese

76 on of CD8+ T cells by Friend retrovirus (FV)-induced Tregs.

77 ation was not required for suppression by FV-induced Tregs, correlating with their high activation st

78 Most interestingly, FV-induced Tregs were able to suppress the function of CD8+

79 Lastly, in vitro-generated induced Tregs (iTregs) were shown to be highly plastic a

80 but significantly blocked alpha-(1,3)-glucan-induced Treg polarization.

81 anced levels of Tregs, suggesting that 3-HAA-induced Tregs contribute to inhibition of Th17 cells.

82 Exogenous hemin induced Treg polarization in purified T cell/monocyte co

83 By contrast, HSCs induced Treg proliferation, which required cell-cell con

84 nal approach, we then demonstrate that human induced Treg cells suppress syngeneic human ILC2s throug

85 ted role for FGFR inhibition in blocking ICI-induced Treg expansion.

86 eg proliferation in vitro, while in vivo ICI-induced Treg expansion was fully abrogated by FGFR inhib

87 ependent AT-II cells were isolated from IDLA-induced Treg expansion.

88 We also show that IFNgamma-induced Treg fragility is required for response to anti-

89 staining Foxp3-transcriptional activation in induced Tregs also promotes CNS2 demethylation, enhancin

90 with UVB phototherapy showed an increase in induced Tregs and tolerogenic DCs accompanied by the dow

91 ng the conversion of CD4(+) Tconv cells into induced Treg cells (iTreg cells).

92 y cells, converted naive CD4(+) T cells into induced Treg cells, and presented antigen by an unusual

93 ing in differentiation of naive T cells into induced Treg.

94 ide impaired effector T cell conversion into induced Tregs in the presence of TGF-beta.

95 nal T cells, promoting their conversion into induced Tregs with increased TSDR demethylation, enhance

96 ventional CD4(+) T cells that converted into induced Tregs.

97 L-2C administered before bilateral renal IRI induced Treg expansion in both spleen and kidney, improv

98 CCL22 + SC-islets induced Treg migration in vitro, with specificity to CCL

99 g, to OVA-sensitized and OVA-challenged mice induced Treg cells and attenuated airway hyperresponsive

100 g, and Ag-expressing B cells from these mice induced Treg division without upregulation of CXCR3.

101 Microglia-induced Tregs were functionally active in vitro by inhib

102 In vitro IFN-beta + MOG-induced Tregs inhibited EAE when transferred into active

103 ed alpha-melanocyte stimulated hormone (MSH)-induced Treg cells specific to ocular autoantigen suppre

104 tigen) or ovalbumin (OVA)-specific alpha-MSH-induced Treg cells.

105 ults suggest that thymic Treg cells, and not induced Treg cells, dominantly mediate tolerance to anti

106 t allograft model, T-bet(-/-) nTreg, but not induced Treg, failed to prolong graft survival as effect

107 These data demonstrate that natural and not induced Tregs are less suppressive in patients with mult

108 Foxp3 to normal amounts in natural, but not induced, Treg cells.

109 Moreover, the ability of induced Treg to control airway hyperreactivity and effec

110 a chain (Il4ra(R576)) promotes conversion of induced Treg (iTreg) cells toward a T helper 17 (TH17) c

111 SC) as being critical for the development of induced Treg cells (iTreg cells) by repression of the T

112 is indispensable for the differentiation of induced Treg cells in vitro and Treg cell mitochondrial

113 tly, perturbations in the differentiation of induced Treg cells was linked to a fatal Th2-type chroni

114 thymic emigrants and the differentiation of induced Treg cells were normal, LRBA-deficient T cells e

115 indings suggest that peripheral expansion of induced Treg cells can serve as a promising therapeutic

116 natural Treg (nTreg) cells and inhibition of induced Treg (iTreg) cell polarization from naive CD4(+)

117 hus, TSLP modulates the activation status of induced Treg through the enhanced uptake of fatty acids

118 ells have been reported as a novel subset of induced Treg cells with modulatory characteristics.

119 is process contributes to the development of induced Tregs.

120 28 costimulation regulates the generation of induced Tregs (iTregs) from naive CD4 T-cell precursors

121 Adoptive transfer of induced Tregs into DC-Tgfbr2 KO mice partially rescued t

122 tural Treg stably express Foxp3, adaptive or induced Treg (iTreg) generated from peripheral CD4 T cel

123 failed to provide TGF-beta1 to drive Th17 or induced Treg differentiation in vitro.

124 affiliation with naturally occurring Treg or induced Treg in the circulating Treg pool.

125 During AAD, T+P-induced Tregs in the lungs displayed a highly suppressiv

126 neutralizing anti-ICOS antibody blocked pDC-induced Treg expansion and interleukin-10 secretion by m

127 lular mechanism or mechanisms underlying PDC-induced Treg generation are unknown.

128 We also show that pDC-induced Tregs can inhibit conventional DC (cDC) maturati

129 whereas adoptive transfer of tolerized pDCs induced Treg cell development and prolonged graft surviv

130 103(+) dendritic cells, such as peripherally induced Treg development or imprinting CCR9 and alpha4be

131 Indeed, the generation of peripherally induced Treg (iTreg) by TGF-beta was highly dependent on

132 xtraintestinal tissues, whereas peripherally induced Tregs retained in the absence of B7 selectively

133 ability of both thymically- and peripherally-induced Treg cells.

134 ammat(+) CD4 T cells, including peripherally-induced Tregs and IL17-producing (Th17) T cells.

135 T3P + Ply-induced Tregs were essential for the suppression of NKT

136 th self-MHC class II is not required for PMA-induced Treg proliferation.

137 D4+ Tregs induced from CD4+CD25- precursors (induced Tregs) also regulate immune responses in the per

138 committed Th1 polarization blocks pregnancy induced Treg differentiation among maternal CD4(+) T cel

139 r differentiation efficiently and to promote induced Treg generation of non-Treg cells lacking both S

140 confirmed the deleterious effect of rapalogs-induced Tregs via a mechanism involving the inhibition o

141 lls had a reduced ability in T-cell receptor-induced Treg generation (p = 0.002 vs. SA; p = 0.001 vs.

142 -experienced Tconv converting into secondary induced Treg through intratumoral activation.

143 tion and proliferation while reducing sepsis-induced Treg and MDSC expansion.

144 gene and the suppressive function of sorted induced Tregs.

145 l homeostasis depends on microbiota-specific induced Treg cells.

146 erentiated into Bet-specific or non-specific induced Treg (iTreg).

147 ternative approaches to generate Ag-specific induced Tregs (iTregs) and tested their efficacy and sel

148 DC function in a model in which Ag-specific, induced Tregs (iTregs) are cocultured with DCs in the ab

149 deficiency in TAZ or overexpression of TEAD1 induced Treg cell differentiation, whereas expression of

150 vated CD4(+) T cells, and peripheral TGFbeta-induced Treg in which it was bound by DNMT1, DNMT3b, MeC

151 Aza plus TGFbeta-induced Treg resembled nTreg, expressing similar recepto

152 ansfer of either nTreg or polyclonal TGFbeta-induced Treg (iTreg) did not prevent AIG, while cotransf

153 TGFbeta-induced Tregs (iTregs) have all the characteristics of n

154 We show that induced Treg cells, but not natural Treg cells, effectiv

155 he thymus, increasing evidence suggests that induced Tregs (iTregs) may be generated in the periphery

156 DCs acted as a pivotal molecular switch that induced Tregs to acquire a stable suppressor phenotype,

157 The induced Treg cells home specifically to the lungs and dr

158 The induced Treg cells suppress nuclear autoantigen-specific

159 s mainly through maintaining survival of the induced Tregs.

160 ntration in the peripheral lymphoid tissues, induced Treg cells.

161 TNFR25-induced Treg proliferation was dependent upon TCR engage

162 pithelium-adapted CD4+ T cells and tolerance-induced Tregs that recognize dietary antigens, suggestin

163 Therefore, ATRA treatment induced Treg cell-dependent immune tolerance by suppress

164 uced by them play an essential role in tumor-induced Treg expansion.

165 molecules and studied their effects on tumor-induced Treg expansion.

166 t an IL-12-IFN-gamma axis can suppress tumor-induced Treg proliferation.

167 we determined whether AREG has a role in UVB-induced, Treg cell-mediated suppression of CHS reactions

168 Vaccine-induced Treg cells thus play a crucial role in the contr

169 Thus, suppression of CD8(+) T cells by virus-induced Tregs occurs in a tissue-specific manner and cor

170 el strategies to generate bona fide in vitro-induced Treg (iTreg) are critical.

171 tion consistent with an uncommitted in vitro-induced Treg-like phenotype.

172 miR-29a impacted the production of in vitro-induced Tregs (iTregs) in overexpression and blocking ex

173 ated the effect of pembrolizumab on in vitro-induced Tregs (iTregs).

174 d for the proper differentiation of in vitro-induced Tregs as well as maintenance of Tregs.

175 oth peripherally derived iTregs and in vitro-induced Tregs.

176 orming growth factor beta (TGFbeta) ex vivo (induced Treg [iTreg] cells) to the effects of equivalent

177 teral administration of retinoic acid, which induced Tregs and decreased NEC severity.

178 unlike oral administration of antigen, which induced Tregs but not effector T cells, i.p. immunizatio