ライフサイエンスコーパス: induced mutation

1 ites of Pol II stalling is predictive of AID-induced mutation.

2 easel is a novel N-ethyl-N-nitrosourea (ENU)-induced mutation.

3 homologs in other bacteria are required for induced mutation.

4 osinase gene had been deleted by a radiation-induced mutation.

5 ng mice homozygous for N-ethyl-N-nitrosourea-induced mutations.

6 ive trait locus (QTL) mapping and mapping of induced mutations.

7 gene PTEN was sequenced and analyzed for UV-induced mutations.

8 activation-induced cytidine deaminase (AID)-induced mutations.

9 ic strategy for the discovery and mapping of induced mutations.

10 erivatives for the frequency and kinds of UV-induced mutations.

11 lecular weight between bases to identify any induced mutations.

12 onstrating efficient transmission of the ZFN-induced mutations.

13 ess was accelerated by N-ethyl-N-nitrosourea-induced mutations.

14 is dominated by ultraviolet radiation (UVR)-induced mutations.

15 amplifications occur as apparent starvation-induced mutations.

16 levated rate of both sporadic and DNA damage-induced mutations.

17 permit the efficient recovery of chemically induced mutations.

18 ints to a substantial contribution of damage-induced mutations.

19 pathway can greatly reduce the frequency of induced mutations.

20 974 data on dominance of spontaneous and EMS-induced mutations.

21 the occurrence and randomness of chemically induced mutations.

22 at G/C pairs were the predominant type of Cr-induced mutations.

23 t reveal any significant epistasis among the induced mutations.

24 f the skin in which p53 is inactivated by UV-induced mutations.

25 eated new opportunities for rapid mapping of induced mutations.

26 epatocarcinogenesis is associated with MeIQx-induced mutations.

27 genes, including Ty retrotransposons and Ty-induced mutations.

28 f the skin in which p53 is inactivated by UV-induced mutations.

29 often due to low tumor purity and treatment-induced mutations.

30 o allows wheat to tolerate high densities of induced mutations.

31 in mice carrying N-ethyl-N-nitrosourea (ENU)-induced mutations.

32 rces available for comprehensive analysis of induced mutations.

33 efficient germ-line transmission of the Cas9-induced mutations.

34 om mice carrying N-ethyl-N-nitrosourea (ENU)-induced mutations.

35 have previously characterized two transgene-induced mutations, 94-A and 94-K, which are allelic with

36 -deficient cells exhibited reduced cisplatin-induced mutation, a process that has been implicated in

37 ra of spontaneous and ethyl methanesulfonate-induced mutations across the Saccharomyces cerevisiae ge

38 Moreover, a recurrent UV-induced mutation activating RAC1 has recently been detec

39 cular lesion responsible for a recessive EMS-induced mutation affecting egg shell morphology by using

40 A screen for N-ethyl-N-nitrosourea (ENU)-induced mutations affecting early development in the asc

41 nt lines revealed >1.8 million canonical EMS-induced mutations, affecting >95% of genes in the sorghu

42 rto unidentified N-ethyl-N-nitrosourea (ENU)-induced mutation affects dorsal root ganglia (DRG) forma

43 analyze mtDNA integrity, damage repair, and induced mutations after exposure of human adult retinal

44 obust mitochondrial damage responses repress induced mutations after mutagen exposure.

45 development either directly or by screening induced mutations against a deletion.

46 oops) generate DNA ends that underlie stress-induced mutation and amplification.

47 We also examined induced mutation and found that either the inability to

48 e D' (3d), a recessive N-ethyl-N-nitrosourea-induced mutation and phenotype in which no signaling occ

49 translesional DNA synthesis in chemotherapy-induced mutation and resistance to front-line chemothera

50 We sequenced 182 UVC (254 nm UV)-induced mutations and 170 mutations induced by a solar U

51 substitutions comprised 86% of the N-OH-AABP-induced mutations and 74% of the spontaneous cII mutatio

52 Although UV-induced mutations and adducts are present in normal-appe

53 bryonic fibroblast cells against methylation-induced mutations and characterize the effect of a parti

54 We found that the frequencies of induced mutations and chromosomal changes in populations

55 test this hypothesis, we measured genotoxin-induced mutations and chromosome damage in p27-deficient

56 s II and IV are responsible for misalignment induced mutations and compete with DNA polymerase V whic

57 al-mosaicism that dominantly eliminates NHEJ-induced mutations and favors inheritance of functional c

58 egies: phenotypic screens for spontaneous or induced mutations and genotypic analysis using homologou

59 enesis by demonstrating that all three drugs induced mutations and led to an increase in the generati

60 lar layer that shapes the specificity of AID-induced mutations and may provide new insights into the

61 ied heteroduplexes derived from a variety of induced mutations and naturally occurring polymorphisms.

62 rately and quantitatively detect favipiravir-induced mutations and to sample orders of magnitude more

63 a 25-fold higher than normal frequency of UV-induced mutations and very unusual kinds (spectrum), mai

64 w to conserve energy, minimize transcription-induced mutation, and permit regulation over the widest

65 te of DNA photoproduct removal, decreases UV-induced mutations, and reduces photocarcinogenesis in UV

66 In addition, how natural variations, induced mutations, and the advanced genome-editing techn

67 e high frequency and abnormal spectrum of UV-induced mutations, and ultimately their malignant transf

68 Natural variation and induced mutations are important resources for gene disco

69 east cells with ultraviolet (UV) light, most induced mutations are inherited by both daughter cells,

70 Recombination-induced mutations are largely independent of mismatch re

71 th a greater burden of somatic HPV16 APOBEC3-induced mutations are more likely to be benign or subseq

72 e, we found in this study that transcription-induced mutations are not limited to specific genes, all

73 In both barley and B. oleracea stable Cas9-induced mutations are transmitted to T2 plants independe

74 The Drosophila transposon P-element-induced mutations are very useful for directly connectin

75 Expression of p48 suppressed UV-induced mutations arising from the nontranscribed strand

76 s suggest genetic reversion due to cisplatin-induced mutations as a distinct mechanism for developing

77 The induced mutations as well as damaged cells would occur t

78 with spontaneous, genetically engineered and induced mutations, as well as 100s of inbred strains and

79 ar to those found in previous studies of EMS-induced mutations, as well as 2.4% indels (insertions an

80 revious work showed that about 85% of stress-induced mutations associated with DNA double-strand brea

81 ides, were then correlated to cell toxicity, induced mutation at the TK (thymidine kinase) and HPRT l

82 wed an increased level of ionizing radiation-induced mutation at the TK and HPRT loci, impaired phosp

83 Our data also indicate that MMS-induced mutations at adenine nucleotides are significant

84 ucts directed by PNAs conjugated to psoralen-induced mutations at frequencies in the range of 0.46%,

85 ves such blocked 3'-termini to suppress Top1-induced mutations at rNMP sites within the genome.

86 ase.' Additionally, the frequency of nickase-induced mutations at the I-AniI site was at least 150-fo

87 e; a comparative analysis reveals that NNRTI-induced mutations behave differently from the others.

88 ow to very low DR, the overall dependence of induced mutations being parabolically related to DR, wit

89 We demonstrate that most break-repair-induced mutations (BRIMs) are point mutations and have a

90 RAD6, and RAD18 did not have any cross-link-induced mutations but showed increased levels of recombi

91 gulated Myc sensitizes B cells to chemically induced mutations, but does not cause, on its own, mutat

92 equencing of mutant chromosomes, to identify induced mutations by comparison to parental chromosomes.

93 iciency revealed by an N-ethyl-N-nitrosourea-induced mutation called elektra.

94 evealed by a recessive N-ethyl-N-nitrosourea-induced mutation called warmflash (wmfl).

95 The characterization of ENU-induced mutations can build on the resources provided by

96 doubleridge is a transgene-induced mutation characterized by polydactyly and syndac

97 Of 106 ZFN-induced mutations characterized, 83 (78%) were simple de

98 dCas9-induced mutations cluster near the guide RNA target regi

99 ees C show much higher frequencies of CRISPR-induced mutations compared to plants grown continuously

100 inst an eGFP transgene in Xenopus tropicalis induced mutations consistent with nonhomologous end join

101 new alleles affected expression of the gypsy-induced mutation ct(6) and found that it was unaltered i

102 UV-induced mutations dominate the trunk, whereas APOBEC-ass

103 ta indicate that DSB-repair-dependent stress-induced mutation, driven by spontaneous DNA breaks, is a

104 describe a novel N-ethyl-N-nitrosourea (ENU)-induced mutation, early doors (Edo), in the PER-ARNT-SIM

105 train that carries a nitrosoguanidine (MNNG)-induced mutation enabling it to accept DNA from Escheric

106 Spontaneous and induced mutation experiments indicated these patterns of

107 ed GPR89, and an N-ethyl-N-nitrosourea (ENU)-induced mutation (explorer) in Gpr89 phenocopied Rabl3 (

108 gulation of the tricarboxylic acid cycle and induced mutation facilitate S. aureus persistence and ev

109 to contain within-host somatic HPV16 APOBEC3-induced mutations (Fisher's exact test, P = 6.2 x 10(-14

110 notypic screening of organisms with randomly induced mutations followed by subsequent identification

111 ic screen of mice with N-ethyl-N-nitrosourea-induced mutations for defects in adaptive immunity, we i

112 We determined non-B DNA-induced mutation frequencies and spectra in human U2OS o

113 rmation and other steps for analyzing damage-induced mutation frequencies and spectra.

114 inum adducts by determining cytotoxicity and induced mutation frequencies at the hypoxanthine guanine

115 Primary XP-C cells had increased UV-induced mutation frequencies compared with normal cells,

116 We incorporate empirical data on CRISPR-induced mutation frequencies in Drosophila.

117 sociated with significant increases in break-induced mutation frequencies, deletion lengths and the a

118 sults in a 6- to 14-fold increase in the MMS-induced mutation frequency and in a significant increase

119 ice displayed a higher N-ethyl-N-nitrosourea-induced mutation frequency in the colon than p27(+/+) li

120 c dead strain of Rev1 exhibits a lower 4-NQO-induced mutation frequency than wild type.

121 he episomal shuttle vector, the psoralen-PNA-induced mutation frequency was 0.13%, 3.5-fold higher th

122 to cytotoxicity and an increase in H(2)O(2)-induced mutation frequency; however, mutation frequency

123 tion-altering potential of 10,913 laboratory-induced mutations from 2372 proteins.

124 In rice, we identified approximately 18,000 induced mutations from 72 independent M2 individuals.

125 Comparison of the A3-induced mutations from reporter cells and the patient-de

126 milarity between the spectra of UVA- and UVB-induced mutations further supports similar mechanisms of

127 Our results indicate that transcription-induced mutations have altered the composition of bacter

128 Over 10,000 such laboratory-induced mutations have been reported in the UniProt data

129 Induced mutations have been used to generate novel varia

130 These results suggest that APOBEC3G-induced mutations have contributed to the evolution of a

131 To see if transcription-induced mutations have influenced the evolution of bacte

132 These ENU-induced mutations hold promise in yielding new insights

133 The signature of induced mutations, i.e., T to C transitions and T to A t

134 Finally, genetic profiling of transposon-induced mutations identified significant differences in

135 This cell culture-induced mutation in HRV16 VPg moderately increased its u

136 were negative for PFOS, we propose that PFOS-induced mutation in liver tissue of lambda transgenic me

137 Here we identify an ENU-induced mutation in mice that reveals a molecular pathwa

138 ated that mice harboring an ethylnitrosourea-induced mutation in the gene encoding mTOR die at embryo

139 As a result of an N-ethyl-N-nitrosourea-induced mutation in the last alpha helix of DCK, a funct

140 ice, resulting from an N-ethyl-N-nitrosourea-induced mutation in the limb region 1-like gene (Lmbr1l)

141 cy does not affect spontaneous and radiation-induced mutation in the mouse germline.

142 efficient heritable transmission of the ZFN-induced mutation in the subsequent generation.

143 e we report that male mice homozygous for an induced mutation in TLS are sterile with a marked increa

144 eplicate the low prevalence of HPV16 APOBEC3-induced mutations in 1,749 additional cases.

145 racea, targeting of BolC.GA4.a leads to Cas9-induced mutations in 10 % of first generation plants scr

146 ion density, we searched 528 individuals for induced mutations in 15 genes for which few or no knocko

147 roximately 1900 ethyl methanesulfonate (EMS)-induced mutations in 192 Arabidopsis thaliana target gen

148 Here we report the identification of EMS-induced mutations in 21 essential loci in the 45D-45F re

149 N-ethyl-N-nitrosourea (ENU)-induced mutations in Adam17 (which is required for AREG

150 n the context of the organ-specificity of IQ-induced mutations in beta-catenin, being highly prevalen

151 Moreover, CRISPR/Cas9 induced mutations in both male and female monkeys, with

152 e (Cloudmap) optimized for identification of induced mutations in Brachypodium.

153 gous effects of ethylmethane sulfonate (EMS)-induced mutations in Caenorhabditis elegans are compared

154 Moreover, damage-induced mutations in cancers accumulate asymmetrically w

155 eas duct cells harbouring oncogenic KRAS and induced mutations in CDKN2A, SMAD4 and TP53 expand in vi

156 We induced mutations in Drosophila melanogaster males by tr

157 We have identified EMS-induced mutations in Drosophila Miro (dMiro), an atypica

158 We found that equitoxic doses of cisplatin induced mutations in fibroblasts lacking polymerase eta

159 isome were invariably repaired, this process induced mutations in flanking DNA at a significantly hig

160 The isolation of chemically induced mutations in forward genetic screens is one of t

161 briefly reviews the relationship between UV-induced mutations in habitually sun-exposed human skin a

162 from three independent N-ethyl-N-nitrosourea-induced mutations in host cell factor C2 (Hcfc2).

163 ntrations of vitamin C can prevent oxidation-induced mutations in human cells.

164 study of spontaneous and ionizing radiation-induced mutations in kidney epithelia and ear fibroblast

165 To study double-strand break (DSB)-induced mutations in mammalian chromosomes, we stably tr

166 To study double-strand break (DSB)-induced mutations in mammalian chromosomes, we transfect

167 During a screen for ethylnitrosourea-induced mutations in mice affecting blood natural killer

168 goal is the identification of experimentally induced mutations in multiple isogenic samples.

169 Functional validation with CRISPR-Cas9-induced mutations in novel genes Tead2, Spred1, and Nav3

170 mutation frequency, it greatly enhanced BPDE-induced mutations in nucleotide excision repair (NER)-pr

171 ns, but in many cases was associated with UV-induced mutations in p53.

172 Finally, UV-induced mutations in PL-fed-mice were decreased by appro

173 n, we determined the spectra of UVA- and UVB-induced mutations in primary human fibroblasts.

174 ents of the frequencies of hydrogen peroxide-induced mutations in proofreading-defective yeast mutant

175 ple recent studies to find unique, treatment induced mutations in sets of isogenic samples with very

176 The ENU-induced mutations in several families were mapped using

177 orrelated this information with peroxidation-induced mutations in several human fibroblast cell lines

178 the frequency and specificity of dG-N(2)-AAF-induced mutations in simian kidney (COS-7) cells.

179 the mouse, we have identified recessive ENU-induced mutations in six genes that prevent normal speci

180 The density of ROS-induced mutations in ssDNA is lower, compared to that ca

181 iver allelic series of ethylmethanesulfonate-induced mutations in target 1-kb loci requested by the i

182 the feasibility of screening for chemically induced mutations in target sequences in Arabidopsis tha

183 and cytological characterization of four EMS-induced mutations in teflon (tef), a gene involved in th

184 ed spontaneous and methylene blue plus light-induced mutations in the cII gene from lambda phage in t

185 The induced mutations in the D310 region were predominantly

186 Here we analyze a set of EMS-induced mutations in the egg gene, identify the molecula

187 target two copies of HvPM19 and observe Cas9-induced mutations in the first generation of 23 % and 10

188 termined whether chronic H. pylori infection induced mutations in the gastric mucosa of male and fema

189 Long-term exposure of HIV-1 to KRAB-PBS2 induced mutations in the HIV-1 PBS that reduced the effe

190 A JPH2 with induced mutations in the joining region (mut(PG1)JPH2) c

191 The pattern of IR-induced mutations in the MMR-deficient animals was notab

192 itrate permeases, a collection of chemically induced mutations in the nrtA gene encoding a 12-transme

193 The absence of drug induced mutations in these sera collected several years

194 are responsible for at least 80% of the UVB-induced mutations in this mammalian cell model.

195 Although induced mutations in traditional laboratory animals have

196 populations were evaluated by screening for induced mutations in two genes of interest and the induc

197 nal signatures and the role of human APOBEC3-induced mutations in viral clearance and cervical carcin

198 It is unclear if APOBEC3-induced mutations in vivo are always lethal or can occur

199 hese results suggest that ionizing radiation-induced mutations in vivo can result from both direct an

200 uency and striking difference in kinds of UV-induced mutations in XPV cells strongly suggest that, in

201 e high frequency and abnormal spectrum of UV-induced mutations in XPV cells, we identified an unlimit

202 Here we show that transposon-induced mutations in Zmiz1 drive expression of a truncat

203 Cisplatin-induced mutations, including short insertions and deleti

204 Introduction of danoprevir and BILN 2061-induced mutations into the original clones by site-direc

205 The formation of MNNG-induced mutations is almost abolished in the rad30Delta

206 demonstrate that the incidence of radi-ation-induced mutations is dependent on the genetic background

207 ycle block in Os and in the 94-A/K transgene-induced mutations is due to disruption of the Anapc10 (A

208 curacy of computational tools for laboratory-induced mutations is much lower than that observed for t

209 Because the frequency of damage-induced mutations is strongly dependent on the repairabi

210 two forms of Pol iota, whose frequency of UV-induced mutations is twice that of XPV cells expressing

211 lthough uracil DNA glycosylases limit APOBEC-induced mutation, it is unknown if subsequent base excis

212 Here, we characterize the ENU-induced mutation lazy mesoderm (lzme), which disrupts th

213 Here we describe an ENU-induced mutation, limulus (lulu), which disrupts gastrul

214 The radiation-induced mutation minute (Mnt) in the mouse leads to intr

215 -CMdA nor N4-CMdC blocked DNA replication or induced mutations, N3-CMdT, O4-CMdT and O6-CMdG moderate

216 clease-induced DSBs strongly activate stress-induced mutations near the DSB, but not globally.

217 One hypothesis is that UV-induced mutations occur only after deamination of the cy

218 Instead, we discover that the laboratory-induced mutations occur predominately at the highly cons

219 ' sites, and in both yeast and human DNA, UV-induced mutations occur primarily by 3' C to T transitio

220 e analysis revealed that the majority of MDA-induced mutations occurred at GC base pairs.

221 xon 3, where a total of 23 (27%) of all PhIP-induced mutations occurred.

222 , we demonstrate loss of mature B cells upon induced mutation of a signaling module of the BCR, not p

223 l cavity could promote tooth development, we induced mutation of epithelial beta-catenin to a stabili

224 ents latency shortening by methylating agent-induced mutation of K-ras.

225 al histology associated with spontaneous and induced mutations of both embryonic and adult mice inclu

226 MCH was chosen to test because induced mutations of the MCH gene in mice cause hypophag

227 Here we show that TALEN of dmrt1 efficiently induced mutations of this gene.

228 The radiation-induced mutation Oligosyndactylism (Os) is associated wi

229 ethal mutation uncovered in a screen for ENU-induced mutations on mouse chromosome 5.

230 The immunovariant N-ethyl-N-nitrosourea-induced mutations Pococurante (Poc) and Lackadaisical we

231 stress (hss) from an ethyl methanesulfonate-induced mutation population.

232 The characteristic PUVA-induced mutations predominate in the p53 mutational spec

233 Next, we show that two EMS-induced mutations, previously shown to interact genetica

234 t IGHV3-23*01 in Ramos cells accumulates AID-induced mutations primarily in the AGCT in CDR2, which w

235 Males homozygous for the repro32 ENU-induced mutation produced by the Reproductive Genomics p

236 avirus integration and ultraviolet-radiation-induced mutations, providing rationale for treatment wit

237 Ac-induced mutations range from small footprints of host se

238 DRC) in cultured human cells and decrease UV-induced mutation rate and photocarcinogenesis in mouse s

239 Recessive N-ethyl-N-nitrosourea (ENU)-induced mutations recovered at the fitness-1 (fit1) locu

240 provide a method for developing large-scale induced mutation resources with relatively small investm

241 , through positional cloning of a chemically induced mutation responsible for a neurobehavioral pheno

242 panel to map two N-ethyl-N-nitrosourea (ENU)-induced mutations responsible for visible phenotypes in

243 The induced mutations showed intrinsic features of Ig V(D)J

244 Genome-wide analysis of these crosslinking-induced mutation sites (CIMS) in HITS-CLIP data for Nova

245 n data analysis take advantage of cross-link-induced mutation sites (CIMS) to refine RNA-binding maps

246 Analysis of the UV-induced mutation spectra revealed that > 90% were point

247 the control (p < 0.008), as well as a unique induced mutation spectrum as established by DNA sequence

248 This difference in the Z-DNA-induced mutation spectrum between mammals and bacteria m

249 nt human cells significantly altered the ICL-induced mutation spectrum from predominantly T-->A to T-

250 The cisplatin-induced mutation spectrum shows good correlation with ca

251 r substitutions in 5'-d(CG) sites in the MDA-induced mutation spectrum.

252 ectra were similar to those reported for *OH-induced mutations, suggesting that *OH generated from po

253 agm Vif inhibited the accumulation of hApo3G-induced mutations, suggesting that SIVagm Vif is indeed

254 The results support efforts to achieve drug-induced mutation suppression of stop codons.

255 utes to chemoresistance as well as treatment-induced mutations, targeting TLS is an attractive avenue

256 Surprisingly, induced mutations temporally lagged behind high levels o

257 rly than late reproductive output, since EMS-induced mutations tend to cause delayed reproduction.

258 tor-induced, but not ionizing radiation (IR)-induced, mutations than similarly treated wild-type cell

259 re, we report a novel, N-ethyl-N-nitrosourea-induced mutation that causes a gain of function in adeno

260 d the zebrafish tortuga (tor) gene by an ENU-induced mutation that disrupts the presomitic mesoderm (

261 receptors, and we describe here a chemically-induced mutation that impairs this response in macrophag

262 cted a forward genetic screen for chemically induced mutations that cause Caenorhabditis elegans to b

263 contractions are regulated, we isolated EMS-induced mutations that cause males to execute prolonged

264 time identification of N-ethyl-N-nitrosourea-induced mutations that cause phenotypes in mice.

265 Moreover, ethyl methanesulfonate-induced mutations that change amino acids within the MBC

266 The three original NTG-induced mutations that defined the whiK/bldM locus each

267 are very successful in diagnosing laboratory-induced mutations that elicit significant functional cha

268 -wide screen for novel N-ethyl-N-nitrosourea-induced mutations that give rise to eye and vision abnor

269 netic screen for N-ethyl-N-nitrosourea (ENU)-induced mutations that increase susceptibility to dextra

270 ndependent, recessive, N-ethyl-N-nitrosourea-induced mutations that map to a approximately 1- to 2-cM

271 ntly fail in correctly annotating laboratory-induced mutations that show no functional impact in the

272 es this loss-of-function phenotype using EMS-induced mutations that specifically alter the nau gene,

273 By screening for chemically induced mutations that suppress the bushy, determinate g

274 We selected for transposon-induced mutations that upregulate P(Y) transcription in

275 nt study, we utilized TALEN- and CRISPR/Cas9-induced mutations to analyze the promoter of the barley

276 The key data supposedly linking smoke-induced mutations to lung cancer were obtained from the

277 rent screening strategies target CRISPR-Cas9-induced mutations to the 5' exons of candidate genes, bu

278 In cancers due to chemically induced mutations, viral infections, somatic and inherit

279 In particular, PFOS-induced mutation was characterized by +1 frameshift muta

280 We present the first study in which an ENU-induced mutation was identified by massively parallel DN

281 In two other families, the ENU-induced mutation was identified--Sema3CL605P was associa

282 N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced mutations was determined in human lymphoblastoid

283 Evidence of APOBEC3-induced mutations was found in gag sequences derived fro

284 Overall, through the recovery of an ENU-induced mutation, we uncovered Megf8 as an essential reg

285 involvement of 5-methylcytosine in sunlight-induced mutations, we have analyzed the cII transgene in

286 The most frequently induced mutations were A to T transversions, which were

287 UVA-induced mutations were characterized by statistically si

288 the presence or absence of HR, and the Z-DNA-induced mutations were characterized.

289 MDA-induced mutations were completely abolished when the add

290 Most of the induced mutations were deletions and single-base-pair su

291 The vast majority (97.5%) of the induced mutations were distinct from natural variations.

292 n the lacI gene, 68% (75 of 111) of the BPDE-induced mutations were G-to-T events, and 58 of 75 (77%)

293 quences in vivo, 83 of 147 (56%) of the BPDE-induced mutations were G-to-T transversions, and 58% (48

294 DMY-nanos3UTR-TALENs induced mutations were passed through the germline to F1

295 Like normal adaptive mutations, gIIp-induced mutations were recA(+) and ruvC(+) dependent and

296 re than 95% of the UVC and solar irradiation-induced mutations were targeted to dipyrimidine sites, t

297 The induced mutations were typically insertions or deletions

298 d mutations in two genes of interest and the induced mutations were validated by sequence analysis.

299 1 replicon and virus systems identified drug-induced mutations within the N-terminal region of NS5A.

300 Ethyl methanesulfonate-induced mutations within the second B-box caused up-regu