ライフサイエンスコーパス: inducible NO synthase

1 are largely abolished by genetic deletion of inducible NO synthase.

2 y to express tumor necrosis factor alpha and inducible NO synthase.

3 nuclear factor kappaB-mediated induction of inducible NO synthase.

4 d in the absence of endothelial, neuronal or inducible NO synthase.

5 e expression of an NF-kappaB-dependent gene, inducible NO synthase.

6 ld asphyxia stress, correlating with induced inducible NO synthase.

7 Jak2 and STAT1, a key factor for expressing inducible NO synthase.

8 matory protein-2 (MIP-2), ICAM-1, IL-10, and inducible NO synthase.

9 netically deficient for IL-12, IFN-gamma, or inducible NO synthase.

10 NA expressions for CINC-1, MIP-2, IL-10, and inducible NO synthase.

11 ble mediators IL-1beta, IL-6, TNF-alpha, and inducible NO synthase.

12 ated mice unable to produce IFN-gamma or the inducible NO synthase.

13 tory blood monocyte-derived DCs that express inducible NO synthase.

14 Nitric oxide (NO) generated by inducible NO synthase 2 (NOS2) affects cellular iron hom

15 nts (TBE1 and TBE2) in the promoter of human inducible NO synthase 2 (NOS2).

16 Previous studies suggested that inducible NO synthase 2 (NOS2/iNOS) is required for norm

17 ha, IL-6, and IL-1beta cytokines, as well as inducible NO synthase-2 in bmMPhis, and also impaired th

18 ng protein (MSP), inhibits the expression of inducible NO synthase, a marker of classically activated

19 rginase I activity and inhibited LPS-induced inducible NO synthase activity in LPS-treated macrophage

20 priming were dependent on NO production via inducible NO synthase and activation of protein kinase G

21 myeloid-derived suppressor cells expressing inducible NO synthase and arginase 1 are induced.

22 characterized, in part, by the expression of inducible NO synthase and arginase I (Arg1) in M1 versus

23 gulators of oxidative stress and complement (inducible NO synthase and C3) and downregulation of spec

24 nes like IL-6, IL-12, IL-23, or enzymes like inducible NO synthase and cyclooxygenase 2, was reduced.

25 creased M1 macrophages that highly expressed inducible NO synthase and decreased M2 macrophages that

26 Reverse transcription-PCR revealed that inducible NO synthase and endothelial NOS but not neuron

27 id cells were delayed in their production of inducible NO synthase and had reduced expression of MHC

28 ssion of TGF-beta, IFN-gamma, TNF-alpha, and inducible NO synthase and higher expression of IL-10 in

29 PS-induced p65 NF-kappaB phosphorylation and inducible NO synthase and ICAM-1 expression.

30 -kappaB DNA-binding activity, and subsequent inducible NO synthase and ICAM-1 expression.

31 ppaB activity and decreased transcription of inducible NO synthase and ICAM-1.

32 atory cytokine that suppresses expression of inducible NO synthase and IFN-gamma, and suppresses Th1

33 er analogous to the regulation of vertebrate inducible NO synthase and malaria parasite (Plasmodium)

34 f cytokine-treated ALR islets to up-regulate inducible NO synthase and produce NO correlated both wit

35 tion of IFN-beta and subsequent synthesis of inducible NO synthase and production of NO.

36 nduced responses, including transcription of inducible NO synthase and secretion of NO.

37 ines CXCL1 and CCL2 as well as expression of inducible NO synthase and such responses required the ki

38 eta1-42 peptides to induce the expression of inducible NO synthase and to stimulate the expression of

39 due to their down-regulatory effect on iNOS (inducible NO synthase) and COX (cyclooxygenase)-2 gene e

40 1(+) cells express Arg1 (arginase) and Nos2 (inducible NO synthase) and suppress CD4(+) T cell prolif

41 elease of a multifunctional mediator NO (via inducible NO synthase) and the proinflammatory cytokines

42 tly and/or indirectly through TNFR1, ICAM-1, inducible NO synthase, and AMPA-GluR, all of which were

43 through multiple mechanisms, including PGE2, inducible NO synthase, and arginase.

44 erized by increased expression of TNF-alpha, inducible NO synthase, and CCR2, CD11b(+)/Ly6C(lo) macro

45 ally proinflammatory proteins such as TNFR1, inducible NO synthase, and ICAM-1 were up-regulated in b

46 reus biofilms revealed increased arginase-1, inducible NO synthase, and IL-10 expression, key mediato

47 -kappaB activity and expression of TNFalpha, inducible NO synthase, and IL-1beta, with enhanced mucop

48 kines, including TNF-alpha and IL-1beta, and inducible NO synthase, and increases in brain-derived ne

49 TLR4, inducible NO synthase, and inflammatory cytokine inducti

50 IL-17, IL-33, thymic stromal lymphopoietin, inducible NO synthase, and MUC5ac in lung tissues.

51 enced by increased levels of IL-1beta, IL-6, inducible NO synthase, and multiple neutrophil/monokine-

52 o the infected lymph node expressed abundant inducible NO synthase, and several Y. pestis homologs of

53 for example, IL-1beta, IL-6, TNF-alpha, and inducible NO synthase, and this effect is antagonized by

54 esion molecules, activation markers, and the inducible NO synthase are up-regulated following the int

55 gamma, produced by activated iNKT cells, and inducible NO synthase, arginase-1, and IL-10 produced by

56 ated tyrosine kinase 3 ligand, c-kit ligand, inducible NO synthase, arginase-1, TNF-alpha, cyclo-oxyg

57 terium, and that expression of TNF-alpha and inducible NO synthase by infected macrophages was depend

58 actor, platelet-derived growth factor B, and inducible NO synthase by the vGPCR-expressing cells.

59 ted mouse macrophages that were deficient in inducible NO synthase caused rapid death of the intracel

60 even in severely immunocompromised- SCID or inducible NO synthase-, CD40-, or IL-12-deficient mice,

61 By increasing both superoxide and inducible NO synthase, CRP resulted in increased nitrati

62 al level, HtyOle inhibited the expression of inducible NO synthase, cyclooxygenase-2 and interleukin-

63 rpose of this study was to determine whether inducible NO synthase deficiency (iNOS(-/-)) affects liv

64 2-TLR6 heterodimer, induces IL-12-dependent, inducible NO synthase-dependent, T-reg-sensitive antilei

65 Blocking arginase and inducible NO synthase did not restore B lymphopoiesis, i

66 lar parasite Leishmania major, expression of inducible NO synthase does not confer a cell-intrinsic a

67 including TNF-alpha and IL-1beta, as well as inducible NO synthase, each regulated by NF-kappaB.

68 aled a transient increase in endothelial and inducible NO synthase (eNOS and iNOS, respectively) mRNA

69 infection, NO, produced by the host via the inducible NO synthase, exerts critical antibacterial eff

70 n endotoxin (LPS)-mediated states of sepsis, inducible NO synthase expression and NO production are a

71 Ag-specific Abs (IgG and IgM) and to require inducible NO synthase expression and NO production.

72 y Th-1-activated killer DCs was dependent on inducible NO synthase expression and NO production.

73 nd NF-kappaB, and a concomitant reduction in inducible NO synthase expression and production of TNF a

74 holipase A(2) (iPLA(2)) in the regulation of inducible NO synthase expression by macrophages in respo

75 e fails to prevent dsRNA- or EMCV-stimulated inducible NO synthase expression by macrophages.

76 cidal phenotype as evidenced by decreases in inducible NO synthase expression concomitant with robust

77 on also induced a marked increase in hepatic inducible NO synthase expression in C56BL/6 mice, but no

78 B activation and required down-regulation of inducible NO synthase expression to exert its protective

79 LPS-stimulated inducible NO synthase expression was 3- to 6-fold higher

80 - were increased, endothelial NO synthase or inducible NO synthase expression was similar in the tumo

81 TNF-alpha, IL-6, NO, and inducible NO synthase expression were inhibited by SAHA.

82 crosis factor alpha and interleukin-6, lower inducible NO synthase expression, and fewer I/R-associat

83 associated with significantly reduced aortic inducible NO synthase expression, decreased plasma and a

84 concomitant with a markedly increased aortic inducible NO synthase expression, significantly elevated

85 vels of ERK-1/2 and p65/RelA (NF-kappaB) and inducible NO synthase expression, suggesting that AnxA1

86 steopontin (OPN), a potent transrepressor of inducible NO synthase expression.

87 LR9 expression, higher IL-12 production, and inducible NO synthase expression.

88 enhanced CD40-induced p38MAPK activation and inducible NO synthase expression.

89 lactone prevents dsRNA- and EMCV-stimulated inducible NO synthase expression; however, bromoenol lac

90 o attenuated morphine-induced p53 as well as inducible NO synthase expression; in contrast, N(G)-nitr

91 The inducible NO synthase gene (iNOS) plays a role in a numb

92 genetic polymorphisms in the promoter of the inducible NO synthase gene (NOS2) could modulate product

93 HIF-alpha isoform-specific regulation of the inducible NO synthase gene by HIF-1alpha, and the argina

94 d to the promoter of the NF-kappaB-regulated inducible NO synthase gene in cells from estrogen-treate

95 mRNA expression levels of the arginase-1 and inducible NO synthase genes, which characterize MDSCs, w

96 displays properties of a heme chaperone for inducible NO synthase, here we investigated whether heme

97 ther BALB/c nor STAT6-deficient MSCs produce inducible NO synthase; however, both produce arginase an

98 ulates several NF-kappaB-regulated proteins (inducible NO synthase, IFN-gamma, and MCP-1).

99 the classical macrophage activation markers, inducible NO synthase, IL-12, and TNF-alpha, as well as

100 uce LPS- and IFN-gamma-induced expression of inducible NO synthase, IL-1beta, and TNF-alpha in vivo i

101 xpression as assessed by measuring levels of inducible NO synthase, IL-6, and IL-8.

102 levels of IFN-gamma, associated with reduced inducible NO synthase immunoreactivity, and lymph node T

103 ed when mice were treated with inhibitors of inducible NO synthase, implicating the NO pathway in par

104 arly, RNS60 also inhibited the expression of inducible NO synthase in activated astroglia.

105 n of nitric oxide (NO) and the expression of inducible NO synthase in activated microglia.

106 ginase 1, with concomitant downregulation of inducible NO synthase in APCs in vitro and in vivo.

107 N-gamma, previously shown to strongly induce inducible NO synthase in human primary astrocytes, induc

108 ombined cytokines up-regulated the NF-kappaB inducible NO synthase in NOD-Rag and C3H/HeJ islets but

109 thase isoforms and absence of Ca-independent inducible NO synthase in PBL.

110 f proinflammatory genes (IL-6, IL-1beta) and inducible NO synthase in response to H. pylori.

111 ddition, expression of interferon- gamma and inducible NO synthase in the heart, which are associated

112 vely cleared despite high level induction of inducible NO synthase in the lesion, and despite their s

113 ation as evidenced by enhanced expression of inducible NO synthase in the lungs of H99gamma-immunized

114 flammatory factors IFN-gamma, TNF-alpha, and inducible NO synthase in the TME merely 4 d postinfectio

115 lecules (reactive oxygen species, TNF-alpha, inducible NO synthase) in 1) M phi propagated from obstr

116 explained by a similar defect in a conserved inducible NO synthase-independent mechanism of innate im

117 ation to the lungs, but rather controlled an inducible NO synthase-independent mechanism of innate im

118 KCa3.1 blocker; and (iii) two inhibitors of inducible NO synthase, indicating that KCa3.1 activity a

119 that inhibiting superoxide production during inducible NO synthase induction would suppress oxidative

120 m that limits IFN-gamma production and local inducible NO synthase induction.

121 Transfection with inducible NO synthase inhibited etoposide-induced apopto

122 acetyl cysteine, extracellular catalase, and inducible NO synthase inhibitors inhibited ICAM-1 and IL

123 Inducible NO synthase (iNOS) activity is induced upon pa

124 Only microglia, but not OLs, expressed inducible NO synthase (iNOS) after LPS challenge; microg

125 macrophage phagocyte NADPH oxidase (phox) or inducible NO synthase (iNOS) alone or, surprisingly, in

126 that in macrophages, H. pylori up-regulates inducible NO synthase (iNOS) and antimicrobial NO produc

127 inflammatory and antiviral genes, including inducible NO synthase (iNOS) and cyclooxygenase (COX)-2.

128 tric oxide (NO) production and expression of inducible NO synthase (iNOS) and cyclooxygenase 2 (COX-2

129 on, cyclooxygenase-2 (COX-2) expression, and inducible NO synthase (iNOS) and cytokine production; wi

130 We find that the induction of inducible NO synthase (iNOS) and cytokines is suppressed

131 trite, nitric oxide (NO) and superoxide, and inducible NO synthase (iNOS) and gp91(phox) protein expr

132 However, translation of inducible NO synthase (iNOS) and NO generation by H pylo

133 paB signaling is essential for Con A-induced inducible NO synthase (iNOS) and NO in murine splenocyte

134 Here, we show that inducible NO synthase (iNOS) and PGHS-1 co-localize in a

135 fibrozil inhibited LPS-induced expression of inducible NO synthase (iNOS) and proinflammatory cytokin

136 ion in WT macrophages suppressed LPS-induced inducible NO synthase (iNOS) and promoted M2 polarizatio

137 ction of inflammatory response genes such as inducible NO synthase (iNOS) and TNF (TNF-alpha) in a PP

138 ibute to the overexpression of NO, including inducible NO synthase (iNOS) and transcription factors S

139 activation and the subsequent expression of inducible NO synthase (iNOS) and vascular cell adhesion

140 tosolic proteins that may be involved, using inducible NO synthase (iNOS) as a model target.

141 NO derived from inducible NO synthase (iNOS) can activate macrophage apo

142 Inducible NO synthase (iNOS) contains an amino-terminal

143 NO produced by inducible NO synthase (iNOS) contributes to ischemic bra

144 ilarly, activated macrophages that expressed inducible NO synthase (iNOS) drove peripheral expression

145 e role of nitric oxide (NO) generated by the inducible NO synthase (iNOS) during myocardial ischemia

146 n allergens disrupt the Arginase1 (Arg1) and inducible NO synthase (iNOS) dynamic in monocytes/macrop

147 Inducible NO synthase (iNOS) expression and production o

148 d CD4(+) IL-10(+) T lymphocytes that inhibit inducible NO synthase (iNOS) expression and protect intr

149 demonstrate IL-4-induced down-regulation of inducible NO synthase (iNOS) expression and survival of

150 nitric oxide (NO) through the inhibition of inducible NO synthase (iNOS) expression in endothelial c

151 f type I IFNs was exerted through inhibiting inducible NO synthase (iNOS) expression in IFNgamma and

152 role of CXCL1 in LTB(4), NADPH oxidase, and inducible NO synthase (iNOS) expression in lungs and neu

153 ic monophosphate interfered with LPS-induced inducible NO synthase (iNOS) expression in RAW264.7 macr

154 Inducible NO synthase (iNOS) expression was restricted t

155 ative stress), cyclooxygenase-2 (COX-2), and inducible NO synthase (iNOS) expression were significant

156 Hepatocytes are capable of repeated inducible NO synthase (iNOS) expression, which occurs un

157 itric oxide (NO) levels but not with reduced inducible NO synthase (iNOS) expression.

158 t and triptolide on the production of NO and inducible NO synthase (iNOS) gene expression and transcr

159 d previously that gene transfer of the human inducible NO synthase (iNOS) gene into tumor cells and t

160 Given that inducible NO synthase (iNOS) has been implicated in IP,

161 Overproduction of NO by inducible NO synthase (iNOS) has been implicated in the

162 Overproduction of nitric oxide (NO) by inducible NO synthase (iNOS) has been implicated in the

163 NO produced by inducible NO synthase (iNOS) has been implicated in vari

164 ulation of both cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS) has been shown to be essent

165 Since nitric oxide (NO) released from inducible NO synthase (iNOS) has been shown to possess i

166 of the inducible cyclooxygenase (COX-2) and inducible NO synthase (iNOS) in activated brain macropha

167 The role of inducible NO synthase (iNOS) in allergic airway inflamma

168 by decreased levels of nitric oxide (NO) and inducible NO synthase (iNOS) in cell culture as well as

169 The importance of NO. produced by inducible NO synthase (iNOS) in controlling murine leish

170 Nitric oxide (NO) that is produced by inducible NO synthase (iNOS) in glial cells is thought t

171 achomatis led to downregulated expression of inducible NO synthase (iNOS) in human mesenchymal stem c

172 Inducible NO synthase (iNOS) in human T cells is implica

173 hanges in transcription of key genes such as inducible NO synthase (iNOS) in hypoxic/ischemic environ

174 Enhanced levels of inducible NO synthase (iNOS) in infected lungs are obser

175 shown to down-regulate IFN-gamma-stimulated inducible NO synthase (iNOS) in macrophages.

176 endothelial NO synthase (eNOS) in bovine and inducible NO synthase (iNOS) in stimulated human endothe

177 , there is deficient granuloma formation and inducible NO synthase (iNOS) induction, increased dissem

178 lished by the removal of NO by the use of an inducible NO synthase (iNOS) inhibitor or iNOS-deficient

179 Inducible NO synthase (iNOS) is a hallmark of chronic in

180 Inducible NO synthase (iNOS) is involved in the producti

181 nflammatory in either constitutive (eNOS) or inducible NO synthase (iNOS) knockout mice with IL-1beta

182 cies results in expression and activation of inducible NO synthase (iNOS) leading to intracellular pa

183 gamma is associated with increased pulmonary inducible NO synthase (iNOS) levels.

184 Flagellin stimulated an increase in inducible NO synthase (iNOS) mRNA and activation of the

185 effects of doxycycline and erythromycin A on inducible NO synthase (iNOS) NO production as well as iN

186 e tumor in mice in which the gene for either inducible NO synthase (iNOS) or endothelial NOS (eNOS) h

187 Nitric oxide (NO) generated from inducible NO synthase (iNOS) participates in immune and

188 as undertaken to investigate the role of the inducible NO synthase (iNOS) pathway in the pathogenesis

189 Nitric oxide (NO) generated by inducible NO synthase (iNOS) plays crucial roles in infl

190 E1-dependent toxicity, whereas inhibition of inducible NO synthase (iNOS) potentiated toxicity.

191 Exemplifying this, ablation of inducible NO synthase (iNOS) protected effector-memory T

192 The production of nitric oxide (NO) by inducible NO synthase (iNOS) regulates many aspects of p

193 rminate infection by upregulating epithelial inducible NO synthase (iNOS) transcription and NO produc

194 To determine whether p300 is involved in inducible NO synthase (iNOS) transcriptional regulation,

195 on of macrophage arginase II (Arg2) inhibits inducible NO synthase (iNOS) translation, causes apoptos

196 Inducible NO synthase (iNOS) was significantly upregulat

197 Elevated levels of inducible NO synthase (iNOS) were also observed in the d

198 WT), endothelial NO synthase (eNOS)(-/-) and inducible NO synthase (iNOS)(-/-) lymphatic vessels to c

199 ines (IFN-gamma, TNF-alpha, IL-6, IL-17, and inducible NO synthase (iNOS)), cell adhesion molecules,

200 Here we show that cells regulate inducible NO synthase (iNOS), an important host defense

201 unosuppressive factors including IL-10, IDO, inducible NO synthase (iNOS), and cyclooxygenase 2 (COX-

202 ethyl)-lysine hydrochloride, an inhibitor of inducible NO synthase (iNOS), and PTIO, a scavenger of N

203 Arginase is the endogenous inhibitor of inducible NO synthase (iNOS), because both enzymes use t

204 ppaB activation and production of TNF-alpha, inducible NO synthase (iNOS), cyclooxygenase-2, IL-1beta

205 In this study, we show a key role of inducible NO synthase (iNOS), expressed by classically a

206 Inducible NO synthase (iNOS), however, was found to be a

207 tory genes (e.g., inducible protein (IP)-10, inducible NO synthase (iNOS), monocyte chemoattractant p

208 s found to inhibit LPS-induced expression of inducible NO synthase (iNOS), proinflammatory cytokines

209 ntestinal epithelial cells the expression of inducible NO synthase (iNOS), the critical enzyme in the

210 er growth in mice that are unable to produce inducible NO synthase (iNOS), the dominant source of NO

211 ion of tumor necrosis factor (TNF)-alpha and inducible NO synthase (iNOS), these cells have been refe

212 on of IFN-gamma, MIP-2, IL-1beta, TNF-alpha, inducible NO synthase (iNOS), TLR2, TLR4, MyD88, and NF-

213 ndent proteins, cyclooxygenase-2 (COX-2) and inducible NO synthase (iNOS), were lower in bystander rh

214 obacter pylori infection, mucosal PC express inducible NO synthase (iNOS), which positively correlate

215 Inducible NO synthase (iNOS)-dependent production of NO

216 IL-4(+) T cells and enhanced recruitment of inducible NO synthase (iNOS)-producing neutrophils to in

217 s required for control of M. tuberculosis is inducible NO synthase (iNOS).

218 chanism is the production of NO derived from inducible NO synthase (iNOS).

219 reversed by anti-IFN-gamma or inhibitors of inducible NO synthase (iNOS).

220 ults in increased production and activity of inducible NO synthase (iNOS).

221 levels in asthma are suggested to be through inducible NO synthase (iNOS).

222 levels in asthma are suggested to be through inducible NO synthase (iNOS).

223 of mice with cardiac-specific expression of inducible NO synthase (iNOS).

224 roduced in large amounts by up-regulation of inducible NO synthase (iNOS).

225 amma and LPS by inhibiting the expression of inducible NO synthase (iNOS).

226 lla strains regain virulence in mice lacking inducible NO synthase (iNOS).

227 ous ceramide treatment induced biogenesis of inducible NO synthase (iNOS)/NO and apoptosis through an

228 acrophages, IFN-gamma-mediated expression of inducible NO synthase (iNOS)/TNF-alpha and NO/TNF-alpha

229 : (i) the effect of O(2) on NO production by inducible NO synthase (iNOS); (ii) the effect of NO on N

230 or necrosis factor-alpha, interleukin-1) and inducible NO synthase (iNOS); the former is dependent on

231 NO, which is due to increased expression of inducible NO synthase, is responsible for apoptosis of I

232 rs (protein kinase Cepsilon, endothelial and inducible NO synthase isoforms, and heat shock protein 7

233 Inducible NO synthase knockout mice exhibited significan

234 +) T cells from BCG-infected DR5, TNFR1, and inducible NO synthase knockout mice had impaired caspase

235 +)FoxP3(+) or CD4(+)Foxp3(+) phenotypes from inducible NO synthase knockout mice.

236 ion studies in myoglobin and endothelial and inducible NO synthase knockout models suggest that only

237 into the cerebellum and brainstem, increased inducible NO synthase levels in the cerebellum and brain

238 Microbicidal NO production is reliant on inducible NO synthase-mediated L-arginine metabolism in

239 py, as suggested by decreased IL-23 mRNA and inducible NO synthase mRNA and protein.

240 tly decreased cytokine-induced activation of inducible NO synthase mRNA expression and NO production

241 Trichinella spiralis infection inhibits host inducible NO synthase (NOS-2) expression.

242 and passive Ab efficacy in mice deficient in inducible NO synthase (NOS2(-/-)) and the parental strai

243 Mice deficient in inducible NO synthase (NOS2(-/-)) exhibited reduced morb

244 y increased mRNA synthesis for IFN-gamma and inducible NO synthase (NOS2) and by NOS2 protein synthes

245 ion have been done in mouse models, in which inducible NO synthase (NOS2) and NO are important compon

246 NO produced by inducible NO synthase (NOS2) is important for the contro

247 ures of EIM include differential patterns of inducible NO synthase (NOS2) mRNA induction in the left

248 Inhibiting inducible NO synthase (NOS2), but not neuronal NOS (NOS1

249 O production by decreasing expression of the inducible NO synthase (NOS2).

250 d: 1) decreased lung neutrophil and monocyte inducible NO synthase (NOSII) expression, and 2) decreas

251 ulting in formation of NO in the presence of inducible NO synthase or conversion to ornithine in the

252 rease the expression of type II NO synthase (inducible NO synthase, or iNOS) decreased PKG expression

253 e M1 genes IL-1beta, IL-6, IL-12, IL-23, and inducible NO synthase owing to enhanced transcriptional

254 Both TGF-beta and inducible NO synthase play an important role in morphine

255 to the tumor killing because an inhibitor of inducible NO synthase prevents IL-12-induced tumor suppr

256 stead, monocyte-derived innate TNF-alpha and inducible NO synthase-producing DCs dominated the antiba

257 e, like MCP-1(-/-) mice, have fewer TNF- and inducible NO synthase-producing dendritic cells (Tip-DCs

258 hat physiologically produced NO from TNF and inducible NO synthase-producing dendritic cells can cont

259 synthase (products of inflammatory TNF- and inducible NO synthase-producing dendritic cells), CD83,

260 immune cells, as evidenced by the absence of inducible NO synthase production in infectious foci.

261 o affected dendritic cells, reducing TNF and inducible NO synthase (products of inflammatory TNF- and

262 Abeta1-42 peptides induced the expression of inducible NO synthase, proinflammatory cytokines (TNF-al

263 romoter by Smyd2 and H3K27 trimethylation at inducible NO synthase promoter by Ezh2 to suppress their

264 Analysis of a 1.7-kb region of the murine inducible NO synthase promoter revealed the presence of

265 Using inducible NO synthase promoter-reporter constructs, we f

266 strate a mechanism for reduced production of inducible NO synthase protein and its NO product.

267 The presence of inducible NO synthase protein in a number of inflammator

268 cancer-prone chronic inflammatory disease), inducible NO synthase protein levels were positively cor

269 ted Ms demonstrated comparable expression of inducible NO synthase protein suggesting that NO synthas

270 oxide dismutase, endothelial NO synthase, or inducible NO synthase protein, but HHcy caused a 100% in

271 LPS-induced cyclooxygenase-2 and inducible NO synthase proteins and NO production were ma

272 ow that viable Mtb elicits the expression of inducible NO synthase, RANTES, IFN-inducible protein 10,

273 Viable Mtb also up-regulates inducible NO synthase, RANTES, IFN-inducible protein 10,

274 the combined influence of NO generated from inducible NO synthase, reactive oxygen species, and alte

275 1400W, an inhibitor of NO production by the inducible NO synthase, reduced HMGB1 release stimulated

276 Genetic or pharmacological inhibition of inducible NO synthase reduces DNA accessibility and supp

277 Abrogation of murine-inducible NO. synthase restores virulence to hmp mutant

278 d are adjacent to macrophages that expressed inducible NO synthase, suggesting a potential protective

279 as well as cells expressing MHC class II and inducible NO synthase, suggesting an induction of potent

280 Fas, Fas ligand, FLIP, TNF-alpha, inducible NO synthase, TGF-beta, and IFN-gamma were high

281 Expression of inducible NO synthase, TGFbeta, NADPH oxidase, VEGF, and

282 4)B radical in the oxygenase domain dimer of inducible NO synthase that was trapped by rapid freeze q

283 gamma, MIP-2, IL-1beta, TNF-alpha, IL-6, and inducible NO synthase; TLR signaling molecules, includin

284 ediators, such as IL-1alpha, IL-1beta, IL-6, inducible NO synthase, TNF, and reactive oxygen intermed

285 s during brain abscess development including inducible NO synthase, TNF-alpha, IL-1beta, CXCL2, and C

286 The inducible NO synthase to arginase ratio was lower in the

287 and genetic or pharmacological inhibition of inducible NO synthase together with the Tandem Mass Tag

288 signal transduction via JAK-STAT, escalating inducible NO synthase transcription levels and promoting

289 Within 2 weeks, 69% of the inducible NO synthase-transduced EB displayed spontaneou

290 poptosis was prevented in the presence of an inducible NO synthase type 2 inhibitor.

291 FN-gamma priming was critically required for inducible NO synthase upregulation, NO production, Rac a

292 ssically activated macrophages, that produce inducible NO synthase via an IFN-gamma-dependent mechani

293 eliminate tumor was moderately impaired when inducible NO synthase was inhibited and greatly impaired

294 Under these conditions, inducible NO synthase was not up-regulated and increased

295 Expression of inducible NO synthase was significantly upregulated in P

296 s nonhemopoietic dependent, whereas IL-6 and inducible NO synthase were derived from both cell types.

297 alpha and expression of cyclooxygenase-2 and inducible NO synthase were still inhibited in MyD88-defi

298 of IL-12p40, matrix metalloproteinase 9, and inducible NO synthase, whereas mRNA and protein levels o

299 However, blocking NO either by inhibiting inducible NO synthase with l-N(6)-(1-iminoethyl)-lysine

300 ydrobiopterin and decreases NO production by inducible NO synthase without affecting constitutive NO