ライフサイエンスコーパス: inducible expression

1 hich was required for its basal and butyrate-inducible expression.

2 ble, at least in part, for cell specific and inducible expression.

3 vel protein-DNA complex responsible for TCDD-inducible expression.

4 of coactivators tend to have more resilient-inducible expression.

5 the u-PAR gene required for constitutive and inducible expression.

6 l were integrated into a single FRT site for inducible expression.

7 samples as well as an experimental model of inducible expression.

8 are especially important for ABA- and stress-inducible expression.

9 ce also show decrease in both basal and xeno-inducible expression and activity of a subset of hepatic

10 ily ligand LIGHT (lymphotoxin-like, exhibits inducible expression and competes with HSV glycoprotein

11 flammatory ligand, lymphotoxin that exhibits inducible expression and competes with HSV glycoprotein

12 discrepancy, we studied the consequences of inducible expression and depletion of MYC in human cells

13 Using cell lines for inducible expression and knockdown of KLF8, we demonstra

14 (p27kip1) in adult mice through doxycycline-inducible expression and show this results in reduced ce

15 ficantly reduced TNFalpha- and P. gingivalis-inducible expression and/or production of a cluster of i

16 We propose that inducible expression and/or suppression of the genes tha

17 rived from homologous to lymphotoxins, shows inducible expression, and competes with herpes simplex v

18 nown as homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein

19 LIGHT [homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein

20 member homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein

21 LIGHT (homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein

22 n ligands homologous to lymphotoxin, showing inducible expression, and competing with herpes simplex

23 s ligand, homologous to lymphotoxin, showing inducible expression, and competing with HSV glycoprotei

24 betaR.Fc (homologous to lymphotoxin, showing inducible expression, and competing with HSV glycoprotei

25 t4 gene is not only subject to Pi-starvation-inducible expression, but that transcript levels may be

26 requently used modules like constitutive and inducible expression cassettes, endogenous gene silencin

27 Here, using an inducible expression cell model developed from a human n

28 wed that homologous to lymphotoxin, exhibits inducible expression, competes with herpesvirus glycopro

29 Regardless of their constitutive or inducible expression, decreased H3K9Ac levels after trea

30 lts in Zea mays mesophyll protoplasts on ABA-inducible expression effects on the Late Embryogenesis A

31 Transient transfection and inducible expression experiments showed that FOXO3a repr

32 fate outcomes, we conducted Ascl1- and Ngn2-inducible expression fate mapping using the CreER/LoxP s

33 Indeed, CRTC2 rescued cAMP-inducible expression for certain genes in CBP/p300 null

34 We observed stable inducible expression for over 1 month, with uniform expr

35 number of studies have reported short-term, inducible expression from helper virus-containing HSV-1

36 goal of this study was to obtain long-term, inducible expression from helper virus-free HSV-1 vector

37 n of transcription factor needed to regulate inducible expression from the circuit.

38 Ni(2)(+)-inducible expression from the CYC6 promoter remained a u

39 However, long-term, inducible expression has not been reported using HSV-1 v

40 ology to study gene function by facilitating inducible expression in a timed and reversible manner.

41 ive expression in epithelial appendages, and inducible expression in additional epithelia, when subje

42 ts showed that both vector designs supported inducible expression in cultured fibroblast or neuronal

43 ansgenic approach that enables selective and inducible expression in mice of FLAG-epitope-tagged, dih

44 keratin 17 (Krt17) shows highly dynamic and inducible expression in skin physiology and pathology.

45 press tet-off supported long-term (2 months) inducible expression in striatal neurons.

46 vated calcineurin and NFATc4, which revealed inducible expression in the heart.

47 expression of ID proteins in the former and inducible expression in the latter.

48 cribe an improved Ca(2+) sensor, GCaMP2, its inducible expression in the mouse heart, and its use to

49 ature characterized by early and late stress-inducible expression in tolerant and intolerant genotype

50 f FUS may give insight into how its stimulus inducible expression may be associated with neurological

51 This was tested using islets with an inducible-expression mutation which renders defined numb

52 sogenic motor neuronal NSC34 cell model with inducible expression of a (G4C2)102 repeat, to investiga

53 1/2 (ERK1/2) MAPK signaling is activated by inducible expression of a BRAF(V600E) oncogene.

54 Inducible expression of a constitutively active form of

55 In contrast, inducible expression of a dominant inhibitor of NF-kappa

56 ere combined with mice that have doxycycline-inducible expression of a dominant-negative (DN) BMPR2.

57 In addition, the inducible expression of a mutant 4E-BP1 protein that can

58 nerated a novel glioma mouse model driven by inducible expression of a mutant EGFR (EGFR*).

59 m has been used in transgenic mice to enable inducible expression of a mutant, constitutively active

60 Inducible expression of a mutated K-ras gene under the c

61 Inducible expression of a PP1 interaction-defective form

62 Inducible expression of a recombinant virus-activated tr

63 e a transgenic mouse that has tamoxifen (Tm)-inducible expression of a subgenomic segment of DA RNA i

64 r S80 in selectively regulating the TNFalpha inducible expression of a subset of NF-kappaB target gen

65 sh orthotopic ovarian tumors, and found that inducible expression of a UBC-targeting shRNA led to tum

66 ablished disease, we engineered a system for inducible expression of activating ligands in tumors.

67 However, tolerized DCs demonstrated a novel inducible expression of aldehyde dehydrogenase 1/2 and p

68 constituted transcription system and that RA-inducible expression of all RARbeta isoforms is abrogate

69 Inducible expression of all three RAP2s conferred tolera

70 erated cardiac-specific transgenic mice with inducible expression of alpha1G, which generates Cav3.1

71 The inducible expression of ampC is controlled by the global

72 Here we generated transgenic mice with inducible expression of an active TAK1 mutant (TAK1Delta

73 Inducible expression of an Atcdc48A Walker A ATPase muta

74 ered a transgenic zebrafish with temperature-inducible expression of an EGFP-labeled single-chain hum

75 t expression of essential genes based on the inducible expression of an enzymatically inactive Cas9 p

76 /-) mice, as well as in transgenic mice with inducible expression of an ERK1/2-inactivating phosphata

77 omyocytes, we generated transgenic mice with inducible expression of an N-terminal FLAG epitope-tagge

78 We generated mice with endothelial-specific, inducible expression of an RAF1 gene with a gain-of-func

79 s study, we used double transgenic mice with inducible expression of angiopoietin-2 (Ang2) to investi

80 Although the basal and inducible expression of anti-apoptotic proteins in TRAF2

81 ic-dependent ribosome stalling that controls inducible expression of antibiotic resistance genes in b

82 cartilage constructs capable of tunable and inducible expression of antiinflammatory molecules, spec

83 The inducible expression of antimicrobial peptide genes in D

84 e immune response in Drosophila involves the inducible expression of antimicrobial peptide genes medi

85 , we demonstrate that ROP represses methanol-inducible expression of AOXI when P. pastoris is culture

86 ofile transcriptional changes in response to inducible expression of Arabidopsis (Arabidopsis thalian

87 sis and perturbing the ARF6 GTP/GDP cycle by inducible expression of ARF6 mutants defective in GTP bi

88 odocyte-specific genetic ablation of XBP1 or inducible expression of ATF6 in mice aggravates DN.

89 Inducible expression of AtMCP1b and AtMCP2b significantl

90 In catecholamine-secreting PC12 cells, inducible expression of B'beta decreased both N-terminal

91 We report here that constitutive or inducible expression of B7-H1, a B7 family molecule wide

92 eared to be a local effect, and regulated by inducible expression of B7-H1, an inhibitory molecule of

93 Inducible expression of Bcl6 increased MLL mRNA levels,

94 mopoietic cell line, TonB210, engineered for inducible expression of Bcr-Abl.

95 gen synthase kinase 3 inhibitors followed by inducible expression of beta-catenin shRNA or chemical i

96 hondrial-targeted bKu binds to ori5 and that inducible expression of bKu triggers petite formation pr

97 Using tetracycline-inducible expression of brain-derived neurotrophic facto

98 These findings document inducible expression of Brk in normal T lymphocytes and

99 We generated mice with doxycycline-inducible expression of Ccne1 (Ccne1(T) mice) and activa

100 Mechanistic studies showed that inducible expression of CD82 in highly metastatic melano

101 e knockout mice were devoid of the basal and inducible expression of certain phase 2 detoxification e

102 acting motif mediates the nitrosative stress-inducible expression of cgb.

103 Inducible expression of chromosomal AmpC beta-lactamase

104 report that both constitutive and IFN-gamma-inducible expression of CIITA in mouse bone marrow-deriv

105 Darby canine kidney (MDCK II) cell line with inducible expression of claudin-8, a tight junction prot

106 Inducible expression of CNS-derived CXCL1 resulted in in

107 TLR-inducible expression of co-stimulatory signals is one of

108 However, it is unclear whether or how the inducible expression of co-stimulatory signals would dis

109 the gene expression profiles resulting from inducible expression of comparable levels of either wild

110 Here, we report that inducible expression of constitutively active MEK1 fails

111 used cre-lox technology to test whether the inducible expression of Cre minimize the deleterious eff

112 ed to produce mice with forebrain-restricted inducible expression of CRH.

113 Moreover, inducible expression of DACH1 augmented DATS-mediated in

114 of resistance; this can be achieved through inducible expression of defense genes or by the concentr

115 x2-interactome in ESC, we engineered ESC for inducible expression of different combinations of epitop

116 cells in transgenic mice, using doxycycline-inducible expression of diphtheria toxin, triggers a sig

117 LNCaP and PC3 prostate cancer cell lines and inducible expression of Dkk-3 reduced LNCaP cell prolife

118 ole of ligand-mediated Wnt signaling through inducible expression of Dkk1, an endogenous secreted inh

119 Here we use an animal model of inducible expression of dominant-negative disrupted in s

120 Although inducible expression of dual-specificity phosphatase 6 i

121 8 gene-deleted mice and transgenic mice with inducible expression of DUSP8 in the heart were used her

122 Inducible expression of each candidate open reading fram

123 Inducible expression of either CFTR or the calcium-activ

124 We first observed efficient inducible expression of enhanced green fluorescent prote

125 The inducible expression of EWS-FLI1 in embryoid bodies, or

126 unction in vivo, we engineered mice with Cre-inducible expression of EWS/FLI-1 from the ubiquitous Ro

127 haracterized in Ba/F3 cells with doxycycline-inducible expression of F/P and in EOL-1 cells.

128 to have impaired migration but rescued with inducible expression of FAK.

129 rexpression of PGC-1alpha also prevented the inducible expression of Fn14 in denervated skeletal musc

130 We utilized transgenic and inducible expression of four transcription factors (Oct4

131 tion of ATF2 abrogates both constitutive and inducible expression of FoxP3 in normal epithelial cells

132 Inducible expression of FXYD2 in INS 832/13 cells produc

133 Inducible expression of Galpha12 or constitutively activ

134 Loss of SERF1 impairs the salt-inducible expression of genes encoding members of a mito

135 The heat-inducible expression of genes that encode BiP2, an endop

136 titative proteomics pipeline that allows for inducible expression of GFP-tagged SMAD proteins followe

137 Inducible expression of GNC demonstrates that GNC-mediat

138 Nevertheless, inducible expression of gneY alleviated all the defects

139 Constitutive and FN-f-inducible expression of GRO-alpha and GRO-gamma were als

140 addition, in transgenic Arabidopsis plants, inducible expression of groEL activated PTI marker gene

141 developed two transgenic mouse lineages with inducible expression of HCV structural proteins and cons

142 not the Refseq Hdac7 (Hdac7-s), promoted LPS-inducible expression of Hdac-dependent genes (Edn1, Il-1

143 of human tissue culture cells prevented the inducible expression of heat shock genes, shown by suppr

144 scription factors (Hsfs) activate the stress-inducible expression of heat shock proteins (Hsps) and o

145 mammary epithelial-specific and doxycycline-inducible expression of HEXIM1.

146 Inducible expression of Hst3p in G1 or G2 triggers deace

147 ionally significant differences in basal and inducible expression of human and murine P-selectin in v

148 ntire human SELP gene recapitulate basal and inducible expression of human P-selectin and reveal huma

149 Inducible expression of human SLUG in the dividing MDA-M

150 Inducible expression of hypoxia-inducible factor 1alpha

151 s into the nuclear genome of tobacco through inducible expression of I-SceI, and showed experimentall

152 ct was attributable to loss of basal and LPS-inducible expression of IFN-beta, which maintains Stat1

153 rticular, which was attributable to impaired inducible expression of IL-18Ralpha, extended beyond an

154 Inducible expression of IL-1alpha mRNA and protein were

155 vate the insulin pathway and alter basal and inducible expression of immunity-related genes in intest

156 2(V617F) knock-in mice with constitutive and inducible expression of JAK2(V617F) in hematopoietic cel

157 LXRs regulate basal and inducible expression of key cholesterol homeostatic gene

158 Tetracycline-inducible expression of KLF4 in B-cell progenitors of tr

159 In addition, inducible expression of KLF4 in the HL60 human acute mye

160 In this study, we showed that the inducible expression of kRasV12 in nontransformed intest

161 le 2HG was associated with repression of the inducible expression of lineage-specific differentiation

162 We describe a system for inducible expression of LPG, applying a novel protein-ba

163 Finally, the DeltaPsi-inducible expression of lrgAB was shown to be dependent

164 Inducible expression of mCREB did not affect baseline se

165 Loss of Nrf2 function blocks the basal and inducible expression of microsomal epoxide hydrolase, a

166 MIR21 inhibitors, and stable cell lines with inducible expression of MIR21.

167 paB site that was also critical for IL-1beta-inducible expression of mouse TSLP.

168 Using inducible expression of MR1, this study demonstrates tha

169 Inducible expression of MtrR was found to repress rpoH e

170 NtMYC2a, b, c are required components of JA-inducible expression of multiple genes in the nicotine b

171 IFN-gamma-inducible expression of multiple genes, including IFN re

172 hypothesis, transgenic mice with doxycycline-inducible expression of murine vascular endothelial grow

173 signaling pathways by using cell lines with inducible expression of mutant alpha1AT as well as liver

174 ver from transgenic mice with liver-specific inducible expression of mutant alpha1AT.

175 we generated a mouse model of selective and inducible expression of mutant DISC1 in astrocytes, the

176 Interestingly, inducible expression of mutant PIK3CA resulted in a robu

177 s of transcription 1 (STAT1), we showed that inducible expression of mutant Ras markedly decreased bo

178 hymus and enhances thymic output; meanwhile, inducible expression of Myc in adult TEC similarly promo

179 e defect was associated with lower basal and inducible expression of MyD88 and reflected impaired act

180 We propose that this process allows pathogen-inducible expression of NBS-LRR proteins and that it con

181 Inducible expression of neoantigens in mice would enable

182 Conversely, the inducible expression of NIPP1 switched the directional r

183 ed both the basal and tert-butylhydroquinone-inducible expression of NQO1, a prototypical Nrf2 target

184 rf2 x Maf to ARE controls both the basal and inducible expression of Nqo1.

185 engineered transgenic mice with doxycycline-inducible expression of Nup88.

186 Here, we show that inducible expression of OCT4 (iOCT4) supports long-term

187 Inducible expression of oncogenic Kras(V12) in hepatocyt

188 sactivation, which is directly implicated in inducible expression of OSM.

189 in the degree of endoreduplication, whereas inducible expression of p21(Waf1/Cip1) in p53-negative N

190 enerated a novel transgenic mouse model with inducible expression of p52 in Clara cell secretory prot

191 We used tetracycline-inducible expression of pairs of scaffolding and regulat

192 We have therefore optimized galactose-inducible expression of PfCRT in S. cerevisiae yeast.

193 Conversely, inducible expression of PGC-1beta in white adipose tissu

194 Regulation of constitutive and inducible expression of pglyrp2 is important for systemi

195 he native pilin, PilE, but supplemented with inducible expression of PilA1 and PilA2 of C. perfringen

196 receptor (ADRB2) antagonist ICI118,551 or by inducible expression of PKA inhibitor (PKI) or of BCL2-a

197 The IFN-inducible expression of PKR, however, was Sp3-independen

198 TBK1-induced RelA phosphorylation results in inducible expression of plasminogen activator inhibitor-

199 Noscapine also abrogated the inducible expression of proteins involved in survival, p

200 We separately generated transgenic mice with inducible expression of proteolytic-resistant alpha1C Pr

201 Moreover, inducible expression of PrsS in PrpS-expressing seedling

202 nnovative bigenic system for the doxycycline-inducible expression of RANKL in the mammary epithelium

203 (Oryzias latipes) osteoporosis model, where inducible expression of receptor-activator of nuclear fa

204 Tetracycline-inducible expression of REDD1 triggers rapid dephosphory

205 ess ongoing transcription but also block the inducible expression of regional genes.

206 ntroducing a dun1 mutation, thus eliminating inducible expression of ribonucleotide reductase in mec1

207 ted transcription factor that regulates drug-inducible expression of several key cytochrome P450 enzy

208 Notably, the inducible expression of several noncoding transcripts wa

209 and MLL4 is required to suppress doxorubicin-inducible expression of several p53-target genes.

210 sis, we generated cell lines for doxycycline-inducible expression of short hairpin RNAs (shRNAs) targ

211 Mice with inducible expression of shRNAs against Anln mRNA develop

212 The inducible expression of SKD1(E232Q) in Arabidopsis resul

213 We have developed a SMA mouse with inducible expression of SMN to address the temporal requ

214 Inducible expression of SSBP2 causes growth arrest and p

215 Furthermore, inducible expression of SSBP2 in the AML cell line U937

216 Remarkably, inducible expression of SSBP2 is accompanied by downregu

217 mutant Ras markedly decreased both basal and inducible expression of STAT1, a transcription factor wi

218 The ligand-inducible expression of Stat5 in transgenic females medi

219 differentiation of embryonic stem cells and inducible expression of tagged proteins.

220 More significantly, adult-onset inducible expression of TAK1DeltaN protected the myocard

221 Inducible expression of TAp73 led to the recruitment of

222 We recently demonstrated that inducible expression of tau truncated at Asp-421 to mimi

223 Inducible expression of TDP-43 specifically in neurons e

224 erated a transgenic mouse model that allowed inducible expression of TGF-beta(1) in keratinocytes exp

225 ere we generated mice with podocyte-specific inducible expression of the APOL1 reference allele (term

226 x 1 (PRC1) components with DSBs generated by inducible expression of the AsiSI restriction enzyme in

227 Heat-inducible expression of the AtCK2 transcript was complet

228 Inducible expression of the carboxyl terminus of either

229 deregulation of matriptase and simultaneous inducible expression of the cognate matriptase inhibitor

230 erated a transgenic mouse that had tamoxifen-inducible expression of the DA L-coding region in oligod

231 Inducible expression of the Dominant Negative protein re

232 ansgenic mouse line with tissue-specific and inducible expression of the EGFR ligand epigen, we showe

233 Using inducible expression of the energy acceptor at multiple

234 We further show that inducible expression of the ErbB2DeltaEx16 variant in ma

235 Inducible expression of the erm erythromycin resistance

236 n important transcription factor involved in inducible expression of the gene.

237 In an analysis of U2OS cell lines with inducible expression of the HCV polyprotein or individua

238 stable A549 human epithelial cell line with inducible expression of the hepatitis C virus protease N

239 We show that inducible expression of the homing endonuclease efficien

240 ibe a transgenic zebrafish line that enables inducible expression of the human AML1-ETO oncogene.

241 To understand the constitutive and inducible expression of the IKKi gene we localized the t

242 our earlier studies by both constitutive and inducible expression of the kras(V12) oncogene, hepatoce

243 Here we demonstrate that inducible expression of the most common HER2 mutant (HER

244 Using doxycycline-inducible expression of the neuronal transcription facto

245 diated by repressing Notch signaling because inducible expression of the Notch Intracellular Domain (

246 ious work from our laboratory optimized MeOH-inducible expression of the P. falciparum malarial paras

247 We also report successful high level inducible expression of the P. vivax orthologue, PvCRT,

248 ferator-activated receptor gamma (PPARgamma)-inducible expression of the potent angiogenic factors VE

249 Inducible expression of the secreted Wnt antagonist Dick

250 Bypassing the native SPI-1 regulation by inducible expression of the SPI-1 activator, HilA, consi

251 ontrol of the tetracycline response element, inducible expression of the target gene is temporally re

252 however, the molecular mechanisms that drive inducible expression of the TG2 gene (TGM2) require eluc

253 genes, although HIRA is not required for IFN-inducible expression of these genes.

254 We also developed mice with inducible expression of transgenes encoding small hairpi

255 a critical need for genetic methods for the inducible expression of transgenes in specific cells dur

256 ines were capable of directing efficient and inducible expression of transgenes in the murine trabecu

257 cluding two gain-of-function models with tet-inducible expression of Trask in tumor cells lacking Tra

258 ssue with carnosol inhibited the pervanadate-inducible expression of tyrosine-phosphorylated beta-cat

259 disease, we generated mice with doxycycline-inducible expression of uncoupling protein-1 (UCP1) in t

260 control of cell adhesion and is required for inducible expression of urokinase-type plasminogen activ

261 indicate that mTORC2 and Akt facilitate CD40-inducible expression of VEGF in EC, which is of clinical

262 Inducible expression of VHR suppressed directional cell

263 /- mice stably transfected with plasmids for inducible expression of wild-type ARD1 protein (KO-WT),

264 L1(+) pre-B ALL together with a new model of inducible expression of wild-type Ikaros in IKZF1 mutant

265 we generated transgenic fruitflies with GAL4-inducible expression of wild-type or mutant csw, the Dro

266 Thus, stress-inducible expression of xCT is a two-step process: under

267 me inhibitor MG132 and lentiviruses enabling inducible expression or knockdown of c-myb were used to

268 4 target genes display STAT4-dependent IL-12-inducible expression, other genes displayed IL-12-induce

269 TPSs showed distinct and, albeit moderately, inducible expression patterns in response to biotic and

270 The second phase is defined by A20, whose inducible expression provides for a rheostat function by

271 A (shRNA-mir) cassette with a locus-defined, inducible expression strategy, we developed a system for

272 ctivity, making them particularly useful for inducible expression studies.

273 icted expression, localization, and cytokine-inducible expression suggest a role in the terminal diff

274 Using an inducible expression system Dominant Negative protein wa

275 urkat cells by using a tetracycline (Tet-on)-inducible expression system down-regulated CXCR4-mediate

276 In this study, using an inducible expression system for an miRNA target message,

277 Using an inducible expression system for the exosome cargo protei

278 ressed HCV core protein using a tetracycline-inducible expression system in HeLa cell lines.

279 Using an inducible expression system in human HT1080 fibrosarcoma

280 Using an ecdysone-inducible expression system in mammalian dopaminergic ne

281 ination of tissue-specific expression and an inducible expression system in the loss-of-function phyB

282 employed a phosphoproteomic screen using an inducible expression system of the bacterial effector av

283 We found that a 2-part nonviral Tet-KRAB inducible expression system repressed expression of a lu

284 Further analysis using an inducible expression system showed that BAK1 accumulatio

285 We used a lac-based inducible expression system to generate a conditional rr

286 Next, we used an inducible expression system to silence MECP2 in neurobla

287 wild-type APC protein was expressed using an inducible expression system, HT-29 cells became sensitiv

288 Using an inducible expression system, we discovered that age-onse

289 Using an inducible expression system, we examined the effects of

290 Using an inducible expression system, we found that IRF4 directly

291 Using an inducible expression system, we observed that this ELANE

292 Using an inducible expression system, we restored Mus81 or Sgs1 t

293 c and anaerobic conditions with an arabinose-inducible expression system.

294 be easily adapted to other organisms with an inducible expression system.

295 Cell-, tissue- or organ-specific inducible expression systems are powerful tools for func

296 system overcomes the limitations of current inducible expression systems by enabling robust spatial

297 roplasts using both constitutive and ethanol-inducible expression systems.

298 liver in a novel transgenic mouse model with inducible expression to screen for changes in gene expre

299 cells overexpressing PKC-delta using a Zn2+ inducible expression vector.

300 For temporal regulation, Cre/loxP-mediated inducible expression vectors were used in combination wi