ライフサイエンスコーパス: inflammatory milieu

1 the innate immune function and reducing the inflammatory milieu.

2 ls) embedded within a robust but ineffective inflammatory milieu.

3 ence the eicosanoid composition of the acute inflammatory milieu.

4 te in hepatic fibrosis and repair within the inflammatory milieu.

5 eated with IL-13 to approximate an asthmatic inflammatory milieu.

6 t vary by tissue site and the context of the inflammatory milieu.

7 lthy and diseased human tendon tissues in an inflammatory milieu.

8 disorders is loss of FOXP3 expression in an inflammatory milieu.

9 her driving exploitation of the protein-rich inflammatory milieu.

10 hing for additional genetic loci shaping the inflammatory milieu.

11 rophages take center stage in regulating the inflammatory milieu.

12 elusive, especially in oral bacteria-induced inflammatory milieu.

13 rategy to foster iTreg differentiation in an inflammatory milieu.

14 8(+)T cells to the liver and exacerbated pro-inflammatory milieu.

15 ance self-antigens even in the context of an inflammatory milieu.

16 lation and differentiation, depending on the inflammatory milieu.

17 d efferocytosis, and thereby promote an anti-inflammatory milieu.

18 s rapidly adapt their functions to the local inflammatory milieu.

19 tect environmental signals and influence the inflammatory milieu.

20 t blocking IL-1 signaling could modulate the inflammatory milieu.

21 f selective recruitment or adaptation to the inflammatory milieu.

22 ith permissive effects on blood pressure and inflammatory milieu.

23 e mammary fat pad further enhanced the local inflammatory milieu.

24 g neurodevelopment or indirectly through the inflammatory milieu.

25 te hippocampal neurogenesis and modulate the inflammatory milieu.

26 d (polyI:C), a viral mimic and an inducer of inflammatory milieu.

27 ch increases both antigen expression and the inflammatory milieu.

28 tory epithelial modulator of the mesenchymal inflammatory milieu.

29 ereby dampening suppression and promoting an inflammatory milieu.

30 protein's activity within the intestinal and inflammatory milieus.

31 Because the inflammatory milieu abounds in proinflammatory cytokines

32 del, unilateral ureteral obstruction-induced inflammatory milieu activated NFkappaB and Smad signalin

33 The inflammatory milieu also stimulates protein catabolism.

34 e a critical mechanism for alteration of the inflammatory milieu and a therapeutic target.

35 ogenic may contribute to both the heightened inflammatory milieu and altered intrahepatic immunity.

36 arthritis and the crosstalk between chronic inflammatory milieu and cell reprogramming.

37 ts when bystander T cells were exposed to an inflammatory milieu and cognate antigens at the beginnin

38 -infected subjects may contribute to altered inflammatory milieu and disease progression in dengue.

39 function more effectively than nTregs in an inflammatory milieu and emphasizes the central role of I

40 ffector cells, which in turn intensified the inflammatory milieu and enhanced the activation of CD8(+

41 ally rich organ, with dynamic changes in the inflammatory milieu and immune cell function underlying

42 plausible biological link between the local inflammatory milieu and its consequence on these genital

43 ly, we found that TLR9L induced a suboptimal inflammatory milieu and promoted the antigen-driven expa

44 y MDSC and tumor growth are regulated by the inflammatory milieu and support the hypothesis that the

45 Although distinct inflammatory milieu and T cell precursor frequencies inf

46 that neutrophil survival is regulated by the inflammatory milieu and that neutrophils demonstrate pla

47 othelial AJs by paracrine S1P release in the inflammatory milieu and the consequent activation of Rac

48 aques, such as a large lipid core, increased inflammatory milieu and thin fibrous caps, have been wel

49 an autonomous role in controlling the local inflammatory milieu and tuning resident T lymphocyte fun

50 rnal PUFA status as a putative marker of the inflammatory milieu appeared to modify the associations

51 s and genital tract when exposed to the same inflammatory milieu as wild-type CD4(+) T cells.

52 growth in hostile environments, such as the inflammatory milieu, as well as its relative resistance

53 We now show that the inflammatory milieu associated with FV infection is not

54 possibility that TNFalpha is central to the inflammatory milieu associated with HD.

55 Our findings identify features of the tumor inflammatory milieu associated with immune control of ca

56 of proliferation, invasive migration, and an inflammatory milieu associated with KISS1-dependent meta

57 variety of conditions that alter the overall inflammatory milieu, be that due to substantial, acute i

58 owth, transmission of nutrients, and an anti-inflammatory milieu between the maternal and fetal inter

59 hat haptoglobin modifies the intra-allograft inflammatory milieu by enhancing levels of the inflammat

60 support the hypothesis that attenuating the inflammatory milieu by inhibiting p38 MAPK activity impr

61 sponse to signals delivered within the local inflammatory milieu by pathogen- or damage-associated mo

62 OPCs themselves contribute to the postinjury inflammatory milieu by producing cytokines that directly

63 cate SDF-1alpha/CXCR4, representative of the inflammatory milieu characterizing many pathologies, as

64 ssociated with marked changes in the soluble inflammatory milieu compared with both chronic hepatitis

65 derscoring a temporally limited, subclinical inflammatory milieu concomitant with rapid re-epithelial

66 ng susceptibility to elevated senescence and inflammatory milieu consistent with senescence secretome

67 4+ T cells that could become activated by an inflammatory milieu consisting of enhanced accessory mol

68 transfer or by otherwise enhancing the anti-inflammatory milieu, could contribute to improved clinic

69 The mild inflammatory milieu created in the dermis by skin laser

70 ro- and anti-inflammatory mediators, and the inflammatory milieu determines whether inflammation succ

71 G) E2 is the most abundant eicosanoid in the inflammatory milieu due to the robust production elicite

72 to influence the CNS cellular and molecular inflammatory milieu during EAE and point to the therapeu

73 KR1B1, supporting in vitro findings that the inflammatory milieu during IDD does not interfere with T

74 To persist in the inflammatory milieu during infection, non-typeable H. in

75 d oil) and, indirectly, by components of the inflammatory milieu eliciting nociceptor excitation and

76 coordinated early viral replication and the inflammatory milieu for optimal DC activation, and an in

77 Combined, these results suggest that the inflammatory milieu found in Crohn's disease could lead

78 lymphocytes from bystanders activated by the inflammatory milieu has been difficult.

79 h hematopoietic cells, other stroma, and the inflammatory milieu have profound effects on key stromal

80 e increased in obesity and contribute to the inflammatory milieu; however, the relationship between s

81 , in an obese state, ATMs may exacerbate the inflammatory milieu important in pathologic responses to

82 ma severity in part by regulating the airway inflammatory milieu in a G protein-independent manner.

83 herapeutic options available to modulate the inflammatory milieu in AF.

84 mokine receptor 1 (ACKR1) supported this pro-inflammatory milieu in aged venules.

85 )-deficient mice occurs through an increased inflammatory milieu in bone and that p47(phox)-Nox2-depe

86 e tissue revealed deletion of Ezh2 decreased inflammatory milieu in both male and female mice compare

87 Macrophages are a major component of the inflammatory milieu in chronic HCV-induced liver disease

88 might be able to reflect disease-associated inflammatory milieu in CSF of subjects with neuroinflamm

89 irway MDRCs contribute differentially to the inflammatory milieu in human asthma and chronic obstruct

90 ular and systemic role of senescence and its inflammatory milieu in influencing arrhythmogenesis with

91 Despite evidence that the inflammatory milieu in MF contributes to disease progres

92 The systemic inflammatory milieu in obesity leads to metabolic and ca

93 s induced by cytokines characteristic of the inflammatory milieu in oxazolone (IL-4) and TNBS (IL-12)

94 axis, we sought to elucidate the circulating inflammatory milieu in patients with RHF.

95 The inflammatory milieu in RA drives endothelial cell activa

96 e reveal for the first time that the sterile inflammatory milieu in SCD promotes caspase-4/11-depende

97 ken together, these results suggest that the inflammatory milieu in sIgM(-/-) mice might confer enhan

98 ic activity in part by enabling a pathogenic inflammatory milieu in the bone marrow.

99 e effects of disordered breast involution on inflammatory milieu in the breast as well as epigenetic

100 n in the context of necrosis to a suboptimal inflammatory milieu in the case of pyroptosis.

101 Treatment results in an attenuated inflammatory milieu in the central nervous system, decre

102 nterleukin-10 (IL-10), indicating an altered inflammatory milieu in the cocultures.

103 These findings suggest that the inflammatory milieu in the epidermal microenvironment in

104 to asthma, M. pulmonis infection elicits an inflammatory milieu in the lungs that skews the immune r

105 ary inflammation and alters the Th17-related inflammatory milieu in the lungs.

106 se meningeal inflammation and the associated inflammatory milieu in the subarachnoid compartment play

107 Chronic inflammatory milieu in the tumor microenvironment (TME)

108 ecies and vasoactive cytokines, altering the inflammatory milieu in the vascular wall and the kidney.

109 ubpopulations may be selected based upon the inflammatory milieu in which they reside.

110 To mimic an inflammatory milieu in wild-type mouse, we triggered ret

111 in islet apoCIII causes promotion of a local inflammatory milieu, increased mitochondrial metabolism,

112 demonstrated that cell death and subsequent inflammatory milieu induce strong neuroinflammatory resp

113 On the other hand, the inflammatory milieu induced by this innate receptor prov

114 was triggered by histones, which induced an inflammatory milieu interleukin-1beta and activated plat

115 Furthermore, our findings show that the inflammatory milieu is critical in regulating this TCR s

116 nt in a transplant model when a less complex inflammatory milieu is involved such as a well-matched g

117 mmatory IL-12 and IL-6, suggesting that this inflammatory milieu is key for functional impairment of

118 tolerance to apoptotic cells (AC) within an inflammatory milieu is vital to prevent autoimmunity.

119 bpopulation dominates the infiltrating renal inflammatory milieu, localizing to the glomeruli.

120 Our data suggest that this inflammatory milieu may potentiate tumour cell death by

121 ROI generated in an inflammatory milieu may stimulate quiescent cells to rap

122 We hypothesized that an allergic inflammatory milieu might facilitate sensitization to in

123 mechanistic understanding of how the chronic inflammatory milieu of adipose tissue in obesity prevent

124 lasia, suggesting that PVs can influence the inflammatory milieu of adjacent airways.

125 remained uninfected but were exposed to the inflammatory milieu of an infected lung, pigs were infec

126 ogenous sources of RNA may contribute to the inflammatory milieu of arteriosclerosis.

127 sively characterized and involve a local pro-inflammatory milieu of cellular and soluble immune media

128 tokine cocktail to closely mimic the Th2 and inflammatory milieu of eosinophilic esophagitis (EoE) an

129 Soluble mediators generated within the local inflammatory milieu of hALX mice showed diminished abili

130 diseases and undernutrition, as well as the inflammatory milieu of infectious diseases, can complica

131 Thus, the inflammatory milieu of insulitis may skew the autoimmune

132 Cellular and secreted factors promote the inflammatory milieu of obesity, but the transcriptional

133 se, rather than the endocrine, adipokine, or inflammatory milieu of obesity.

134 GM-CSF has a major role in the immune and inflammatory milieu of the airway.

135 thesis, we studied the effects of the highly inflammatory milieu of the atherosclerotic plaque on IGF

136 G9acKO mammary morphological defects on the inflammatory milieu of the host mammary fat pad.

137 ifferent infections and is influenced by the inflammatory milieu of the host.

138 atory cells and display an alteration in the inflammatory milieu of the serum and cerebrospinal fluid

139 We sought to broadly define the inflammatory milieu of the upper respiratory tract in AE

140 bscess as a tool to query effects of the CNS inflammatory milieu on astrocyte GJ communication and el

141 ide trimming and the contribution of the T1D inflammatory milieu on these mechanisms are unknown.

142 nsequence of modulation and imprinting by an inflammatory milieu or, more likely, whether it reflects

143 the competitive advantage of MDS HSPCs in an inflammatory milieu over normal HSPCs remain poorly defi

144 If both anti-CD3 and the inflammatory milieu persisted beyond day 10, intermediat

145 An important component of the inflammatory milieu, PKA internalizes Slack channels fro

146 ponse by participating in the intra-amniotic inflammatory milieu preceding Ureaplasma parvum-induced

147 hough mutant cells are more resilient to the inflammatory milieu, probably through the acquisition of

148 s-infected macrophages and influenced by the inflammatory milieu, promote the generation of osteoclas

149 h outcomes that depend on the presence of an inflammatory milieu, providing a mechanistic explanation

150 lipopeptides have the capacity to induce an inflammatory milieu reminiscent of that found in early s

151 In the inflammatory milieu, RvE1 mediates counter-regulatory ac

152 In addition to the murine inflammatory milieu, RvE2 was also identified in plasma

153 ge-attracting chemokine in the context of an inflammatory milieu, such as that induced by a viral inf

154 tation and tolerance induction provide a pro-inflammatory milieu that alters the stability and functi

155 d-type littermates, thus maintaining an anti-inflammatory milieu that could avoid insulin resistance.

156 Here we characterize the inflammatory milieu that drives both niche and haematopo

157 We defined the inflammatory milieu that in part drives CysLT overproduc

158 rea) may contribute to creating the systemic inflammatory milieu that is linked to atherogenesis.

159 Neuronal injury occurs in an inflammatory milieu that is populated by resident and so

160 accumulation of senescent cells generates an inflammatory milieu that leads to chronic tissue damage

161 restrained TLR signaling generates a chronic inflammatory milieu that often leads to autoimmunity.

162 SIV infections is a rapidly developing anti-inflammatory milieu that prevents chronic activation, ap

163 glion-resident myeloid cells, engendering an inflammatory milieu that promotes CIPN.

164 led with interleukin-2 insufficiency and the inflammatory milieu that promotes reprogramming.

165 t SP110b plays a crucial role in shaping the inflammatory milieu that supports host protection during

166 hallmarks are driven by a complex cutaneous inflammatory milieu that varies between patients.

167 Only in inflammatory milieus that upregulated CD25 did the provi

168 ropose that C3aR activation alters the tumor inflammatory milieu, thereby promoting tumor growth.

169 endogenous flagellin, suggesting that, in an inflammatory milieu, TLR signaling promotes acquisition

170 ory T cells) or acting in the presence of an inflammatory milieu to abort immune responses at the tar

171 s (LX) are autacoids that act within a local inflammatory milieu to dampen neutrophil recruitment and

172 aturated fatty acids that act within a local inflammatory milieu to stop leukocyte recruitment and pr

173 is characterized by the reinstatement of an inflammatory milieu triggering childbirth.

174 rneal epithelial cells under homeostatic and inflammatory milieus was profiled to examine their contr

175 ammaR-mediated phagocytosis to proceed in an inflammatory milieu, while apoptotic cell clearance is n

176 e in the diseased kidney in favor of an anti-inflammatory milieu with a reduction of pathogenic myelo

177 ire, persistent antigenic stimulation and an inflammatory milieu with elevated B cell-activating fact

178 How they regulate the inflammatory milieu within different adipose depots rema

179 hepatic fibrosis and affects the pathologic inflammatory milieu within the fibrotic liver.

180 hus, COVID-19 is associated with a selective inflammatory milieu within which the apoptotic pathway i