ライフサイエンスコーパス: inheritance

1 variants contribute (oligogenic or polygenic inheritance).

2 buted DNA replication origins for its stable inheritance.

3 n above the 50% value predicted by Mendelian inheritance.

4 including 2 families with autosomal dominant inheritance.

5 ee analysis suggested an autosomal recessive inheritance.

6 d across generations via epigenetic germline inheritance.

7 n (IGR) approach to studies of 'non-genetic' inheritance.

8 -centrin arm structure facilitates flagellum inheritance.

9 sm underlying robust yet flexible epigenetic inheritance.

10 ays an essential role in promoting flagellum inheritance.

11 t account for the complexities of tetrasomic inheritance.

12 Cohesin is essential for genome folding and inheritance.

13 d putative paradigms of mammalian epigenetic inheritance.

14 ation of heterochromatic foci and epigenetic inheritance.

15 carriers of m.14674T>C, supporting a digenic inheritance.

16 ished the existence of a non-genetic mode of inheritance.

17 sed siblings, suggesting autosomal recessive inheritance.

18 ch follows an autosomal recessive pattern of inheritance.

19 onsistently generate and track non-Mendelian inheritance.

20 lain the recessive pattern of kidney disease inheritance.

21 nson disease: Mendelian versus non-Mendelian inheritance.

22 significantly different between each mode of inheritance.

23 lity of CENP-A ensures epigenetic centromere inheritance.

24 subject to change over time based on social inheritance.

25 arthropod reproduction to promote their own inheritance.

26 l mitochondria ensure maternal mitochondrial inheritance.

27 y selfishly distorting the laws of Mendelian inheritance.

28 ing, has demonstrated their complex compound inheritance.

29 endelian model linking monogenic and complex inheritance.

30 cal trials for RP and its different modes of inheritance.

31 ogenicity, population frequency, and mode of inheritance.

32 aptability, and transgenerational epigenetic inheritance.

33 y dysfunction, following a recessive mode of inheritance.

34 dromic polymicrogyria of autosomal recessive inheritance.

35 nderstanding of intergenerational epigenetic inheritance.

36 fied 29 patients with evidence of oligogenic inheritance.

37 uclear region and participates in apicoplast inheritance.

38 erase complex extend lifespan and enable its inheritance.

39 ng trio data phased using Mendelian rules of inheritance.

40 enetic msh1 'memory' with multi-generational inheritance.

41 fully penetrant autosomal recessive mode of inheritance.

42 red ancestry of infections and non-Mendelian inheritance.

43 us embryos, suggestive of a dominant mode of inheritance.

44 nsporter deficiency with autosomal recessive inheritance.

45 NA-mediated chromatin changes and epigenetic inheritance.

46 mmetry (23%) in comparison to other modes of inheritance.

47 feedback loop ensuring long-term centromere inheritance.

48 own mice than would be expected by mendelian inheritance.

49 ignals are integrated to terminate organelle inheritance.

50 d X-linked recessive, and 1 was of uncertain inheritance.

51 tical framework to infer underlying rules of inheritance.

52 alaise associated with an autosomal-dominant inheritance.

53 otransposons are required for stable genetic inheritance.

54 families with dominant and 1 with recessive inheritance.

55 ntial roles in heterochromatin spreading and inheritance.

56 [25], codon reassignment [26], and cortical inheritance [27], for which the ciliate clade is renowne

57 ating-type, such as uniparental mitochondria inheritance, (3) accumulation in the margin of nonrecomb

58 be restricted to DNA sequence-based genetic inheritance alone but to also involve epigenetic factors

59 We assessed APOE4 inheritance among 83 consecutive young males with cALD p

60 ide a deep exploration of sRNA variation and inheritance among a panel of 108 maize (Zea mays) sample

61 karyotes, raising intriguing questions about inheritance and (in)stability of mtDNA in such systems.

62 We discuss the clinical features, mode of inheritance and biological aspects of tumorigenesis, whe

63 perAF ring morphologies according to mode of inheritance and disease-causing gene by using SW-AF imag

64 However, the genetic basis for the inheritance and genesis of these lesions has remained un

65 mation, and to study the effects of maternal inheritance and impaired homology on efficiency.

66 ght bridge the gap between molecular genetic inheritance and phenotypic consequence in terms of incom

67 d its progenitors reveal varying patterns of inheritance and post-formation introgression.

68 hange lies at the core of debates on genetic inheritance and resilience to climate change of prehisto

69 sion to investigate the biology of component inheritance and resistant allele formation, and to study

70 or genotype subgroup classification based on inheritance and the presence of truncating variants.

71 behaviour', 'cultural evolution', 'cultural inheritance', and 'implicit learning' are the main candi

72 ly member with appropriate X-linked dominant inheritance, and receipt of conventional therapy for at

73 A dominant mode of inheritance appears intrinsic to certain missense varian

74 sortment of chromosomes during mitochondrial inheritance appears to have contributed to a history of

75 ting, polyploids, characterized by polysomic inheritance, approach HWE gradually.

76 The patterns of inheritance are consistent with a polygenic architecture

77 Different patterns of inheritance are discussed.

78 Different modes of non-genetic inheritance are expected to affect population persistenc

79 py of the transfer-DNA in the genome and its inheritance as a single locus.

80 Our observations support selective inheritance at the organelle level through a series of d

81 icality and baselines, relevant evolutionary inheritances beyond genes, assessment of cultures and pr

82 entromeres are the basic unit for chromosome inheritance, but their evolutionary dynamics is poorly u

83 f oskar during embryogenesis to minimize its inheritance by pole cells.

84 tinitis pigmentosa (RP) according to mode of inheritance by quantifying the progressive decrease of t

85 distinct mechanism that achieves uniparental inheritance by segregation of parental mitochondria.

86 ani body has a minor role in mtDNA selective inheritance by supplying healthy mitochondria to the pol

87 in the posterior cytoplasm, leading to their inheritance by the germline daughter cell.

88 t often has an autosomal-dominant pattern of inheritance, cases of incomplete penetrance and evidence

89 opose a mechanism whereby loss of phenotypic inheritance causes increased frequency of persisters.

90 nt subunits display different phenotypic and inheritance characteristics.

91 are eager to claim that nongenetic modes of inheritance characterized in this and other model system

92 d that adapted rho(0) cells bypass the mtDNA inheritance checkpoint, exhibit increased mitochondrial

93 However, uniparental inheritance creates conditions for cytonuclear conflict

94 ppear in SDH mutation carriers with dominant inheritance due to loss of heterozygosity in susceptible

95 se structures, safeguarding their asymmetric inheritance during Saccharomyces cerevisiae mitosis.

96 s a key deterministic force, but identifying inheritance effects in a systematic manner has been chal

97 poradically or as a consequence of Mendelian inheritance, for example in cystic fibrosis, primary cil

98 mammals are also implicated in exclusion and inheritance functions.

99 clades appears largely governed by vertical inheritance, gene loss, and homologous recombination.

100 tress response and signals transgenerational inheritance in C. elegans.

101 Studying the mechanisms of epigenetic inheritance in humans is challenging because it is diffi

102 e novo missense variants in Online Mendelian Inheritance in Man (OMIM) genes of up to 0.86 using exon

103 Online Mendelian Inheritance in Man, the Functional Annotation of the Mam

104 on the phenomenon of non-DNA sequence-based inheritance in multiple species, including mammals, urge

105 epigenetic-like mechanism of adaptation and inheritance in S. solfataricus The identification of her

106 ed-RNA-directed transgenerational epigenetic inheritance in the C. elegans germline.

107 e we investigate the existence of epigenetic inheritance in the honey bee.

108 werful and timely tool for detecting digenic inheritance in WES data from patients.

109 locus genome-wide test for detecting digenic inheritance in WES data.

110 ic birth defects often exhibit non-Mendelian inheritance, incomplete penetrance or variable expressiv

111 ow into the ways in which these two forms of inheritance interact over development, and a chance to d

112 loss-of-memory mutants, which affect memory inheritance into progeny.

113 has confirmed the contribution of polygenic inheritance involving common alleles of small effect, a

114 RNAi inheritance is associated with Histone-3-Lysine-9 tri-me

115 Increasing evidence shows that quantitative inheritance is based on both DNA sequence and non-DNA se

116 ons, furrow ingression asymmetry and midbody inheritance is consistent, suggesting specific regulatio

117 The evolutionary significance of epigenetic inheritance is controversial.

118 the many human diseases in which oligogenic inheritance is emerging as a mechanism for heritability.

119 This spectacular example of 'epigenetic' inheritance is explained by a super-efficient maintenanc

120 Oligogenic inheritance makes the etiology of developmental diseases

121 traploid species under a rigorous tetrasomic inheritance model.

122 domains would experience unbalanced tetramer inheritance more frequently, and thereby be less stable.

123 ntify locus-specific examples of nonadditive inheritance, mostly characterized as partial or complete

124 ionary and ecological roles of 'non-genetic' inheritance (NGI) is daunting due to the complexity and

125 cellular mechanisms through which nongenetic inheritance occurs.

126 eases, such as cystic fibrosis (CF), require inheritance of 2 mutated genes.

127 roach, copy-grafting, that permits selective inheritance of a desired allele located in close proximi

128 During cell division, the inheritance of a functional endoplasmic reticulum (ER) i

129 whose mutation is characterized by recessive inheritance of a long 26 hr period phenotype, encodes an

130 gaster, exposure to predatory wasps leads to inheritance of a predisposition for ethanol-rich food fo

131 ms might well underlie the transgenerational inheritance of acquired phenotypic traits in general and

132 to promote the epigenetic transgenerational inheritance of adult onset disease.

133 However, the inheritance of alkyl side-chain length has not been reso

134 e homoploid hybrid plant species through the inheritance of alternate alleles at genes that determine

135 that HHS may occur relatively easily via the inheritance of alternate parental premating isolating ge

136 robust means by which a prion can facilitate inheritance of an activated chromatin state to provide a

137 t drives the emergence and transgenerational inheritance of an activated chromatin state.

138 tly inherited, no mechanism that facilitates inheritance of an activated domain has been described.

139 ich de novo self-organization, as opposed to inheritance of an already organized state, can suffice t

140 he egg in females, each carrying the genetic inheritance of an individual.

141 ed populations, which can support phenotypic inheritance of antibiotic resistance in both V. cholerae

142 J recognition and T hydroxylation, ensuring inheritance of base J in specific sequence patterns foll

143 omponents are required for transgenerational inheritance of both avoidance behavior and ASI daf-7 exp

144 lation pattern is naturally explained by the inheritance of both cell size and cell-cycle speed over

145 may result in uniparental disomy (UPD), the inheritance of both homologs of a chromosome from one pa

146 oteins play critical roles in the epigenetic inheritance of cell fate.

147 ding FUCCI markers, to determine patterns of inheritance of cell-cycle phase durations and single-cel

148 o describe stochasticity of partitioning and inheritance of cell-cycle-phase times, and an ordinary d

149 pagating chromatin structure based on stable inheritance of CENP-A containing nucleosomes.

150 Previous studies suggest asymmetric inheritance of centromeric proteins upon stem cell divis

151 To examine the inheritance of chemical phenotype (chemotype), THCAS and

152 a cilia remnant that promoted the asymmetric inheritance of ciliary signaling components and supporte

153 d also explores mechanisms that restrict the inheritance of deleterious mtDNA variants in the Drosoph

154 strained by inheritance of the microbiome or inheritance of diet selection, offering support for the

155 The reconciliation between Mendelian inheritance of discrete traits and the genetically based

156 glyphosate can induce the transgenerational inheritance of disease and germline (e.g. sperm) epimuta

157 To ensure the faithful inheritance of DNA, a macromolecular protein complex cal

158 egregated in the offspring of this bull, and inheritance of either allele produced polled calves.

159 In Sri Lanka, co-inheritance of either excess alpha globin genes in beta

160 attention to the importance of sex-selective inheritance of environmental effects and raise new quest

161 echanistic description of trans-generational inheritance of epigenetic information in mammals.

162 uclear RNAi in C. elegans, ensuring faithful inheritance of epigenetic memories.

163 These results demonstrate the inheritance of exercise-induced cognition enhancement th

164 an Australian family with autosomal dominant inheritance of frontotemporal dementia and amyotrophic l

165 work uncovers principles of maintenance and inheritance of gene expression states and their regulato

166 We hypothesized that recessive inheritance of gene-disrupting variants may represent a

167 However, the inheritance of genes differentially expressed between cr

168 Inheritance of H3K27me3-lacking sperm chromosomes result

169 ome is required for spreading and epigenetic inheritance of heterochromatin in fission yeast.

170 ly in the form of H3-H4 tetramers, underlies inheritance of heterochromatin.

171 , published from 1780 to 1910, examining the inheritance of insanity.

172 Whether inheritance of leptin concentrations is quantile depende

173 Crossovers can be measured by observing the inheritance of linked transgenes expressing different co

174 for the sequestration event, preventing the inheritance of long-lived nucleoporins and senescence fa

175 Further, inheritance of low NPF expression in specific regions of

176 tly, explant organization requires polarized inheritance of maternal factors from dorsal-marginal reg

177 ish, germ layer specification depends on the inheritance of maternal mRNAs [1-3], cortical rotation t

178 ained, with DNA methyltransferases mediating inheritance of methyl marks onto nascent DNA over cycles

179 ession of transposable elements, uniparental inheritance of mitochondria and plastids, anti-cancer me

180 chondria to the poles results in uniparental inheritance of mitochondria, wherein two of the four spo

181 share a conserved domain with yeast Altered Inheritance of Mitochondria24.

182 ion of one genome over another to affect the inheritance of mitochondrial diseases and guide the evol

183 A popular model posits that inheritance of modified histones, especially in the form

184 Despite their ubiquitous expression, the inheritance of monoallelic germline mutations in breast

185 Recent work now reports the levels of inheritance of mtDNA heteroplasmy in humans and also exp

186 elic fractions of 5-25%, implying biparental inheritance of mtDNA in 0.06% of offspring.

187 ic trait characterized by autosomal dominant inheritance of multiple copies of TPSAB1 encoding alpha-

188 f affective behaviors.SIGNIFICANCE STATEMENT Inheritance of mutations in genes encoding presenilin 1

189 ms of Alzheimer's disease (AD) are caused by inheritance of mutations of PS.

190 ant thyroid hormone status to the epigenetic inheritance of neurological phenotypes, we examined gene

191 and Esrrb act as resilient TFs governing the inheritance of nucleosome positioning at regulatory regi

192 -drive systems in diploid organisms bias the inheritance of one allele over another.

193 ate leads to an adjustment of the positional inheritance of parental nucleosomes that reflects the co

194 Transgenerational epigenetic inheritance of pathogenic learning may optimize progeny

195 de the first comprehensive assessment of the inheritance of PD in the common bean (Phaseolus vulgaris

196 re families with apparent autosomal dominant inheritance of PDS in which the risk to relatives may be

197 olin has on the epigenetic transgenerational inheritance of prostate disease, and to characterize by

198 Inheritance of recessive mutations in SLC4A4 causes prox

199 The inheritance of regulators through cell division is a key

200 Inheritance of resistance to Cry1Ac was recessive and ti

201 of consequences for the spread, fitness, and inheritance of resistance traits, and, particularly in t

202 Inheritance of resistance was recessive and tightly link

203 have been associated with transgenerational inheritance of responses to a high-fat diet(9), thus rai

204 previously suggested, but through asymmetric inheritance of Sara-positive endosomes.

205 ablish a mechanism for epigenetic memory and inheritance of spatial organization of the genome.

206 perenniality, potentially due to the shared inheritance of specific evolutionary precursors.

207 part of this predisposition is caused by the inheritance of specific genetic variants.

208 supporting catalytic processes, storage and inheritance of specific molecules, and buffering noise a

209 tions in long RNA in sperm contribute to the inheritance of specific trauma symptoms.

210 is non-functional and confers mono-factorial inheritance of sterility.

211 th, division, cell volume and shape with the inheritance of the genome.

212 Diets were not constrained by inheritance of the microbiome or inheritance of diet sel

213 x relationship between tree topology and the inheritance of the mutations labeling that topology.

214 Inheritance of the newly assembled flagellum in the huma

215 iae mitotic spindle and primes the invariant inheritance of the old spindle pole body (SPB, the yeast

216 C(1):F(3)) and were tested for stability and inheritance of the resistance.

217 etic analyses support a scenario of vertical inheritance of the Sec trait within eukaryotes and fungi

218 increasingly important to keep track of the inheritance of the selected traits under continuous impr

219 trate its ability to promote super-Mendelian inheritance of the separate transgenes.

220 s, there have been few recent studies on the inheritance of the shell traits.

221 Inheritance of the single mitochondrial nucleoid (kineto

222 We induced super-Mendelian inheritance of the X-chromosome-shredding I-PpoI nucleas

223 ognition, but very little is known about the inheritance of these effects to sedentary offspring and

224 c non-coding SNVs implies a complex compound inheritance of these pulmonary hypoplasias.

225 al small RNAs, and for the transgenerational inheritance of this behaviour.

226 equences, NT can also promote the nongenetic inheritance of traits during this conserved mechanism of

227 dissected and quantified the maintenance and inheritance of transcriptional reinduction memory in ind

228 ntal patterns, providing a genetic basis for inheritance of tumor susceptibility.

229 mobilizes DNA repair factors to prevent the inheritance of unrepaired and broken chromosomes.

230 itability estimates revealed low to moderate inheritances of relative and absolute bioaccessibility,

231 Pedigree analysis revealed inheritance only through the maternal line, consistent w

232 nconsistent with disease prevalence, mode of inheritance, or clinical penetrance.

233 granules is to organize RNA-based epigenetic inheritance pathways and that germ granule loss has cons

234 Although an autosomal-recessive inheritance pattern has been hypothesized, pathogenic va

235 romere-proximal interval and has a sterility inheritance pattern modulated by TaMs5-D but not TaMs5-B

236 function and underscoring a highly polygenic inheritance pattern that may be another important contri

237 e data independent of clinical phenotype and inheritance pattern to identify deleterious mutations in

238 o allele frequency and effect on protein and inheritance pattern, 321 genetic variants (representing

239 specific and less likely to have a Mendelian inheritance pattern, and they tend to cluster in some bi

240 ally in those from families with a recessive inheritance pattern, who may benefit from early diagnosi

241 ce viable animals exhibiting a non-Mendelian inheritance pattern.

242 tree inference methods and evaluating common inheritance patterns across patients.

243 signed to account for the subclonal mutation inheritance patterns characteristic of tumor evolutionar

244 with establishing predetermined spindle MTOC inheritance patterns during stem cell division have been

245 Inheritance patterns of F(2) progeny were non-Gaussian a

246 breeds, by RNA-Seq in order to determine the inheritance patterns of gene expression.

247 study is the first to provide an overview of inheritance patterns of the transcriptome in layers and

248 procal F1 hybrids permitted investigation of inheritance patterns that govern transcriptomic differen

249 Improved insight into the inheritance patterns, arrhythmic risks, and molecular me

250 ntifying mechanisms of diseases with complex inheritance patterns, such as macular telangiectasia typ

251 These settings involve different inheritance patterns, time scales, chromatin structures,

252 with many large pedigrees showing autosomal inheritance patterns.

253 possible deviations from neutrality in their inheritance patterns.

254 ther observed that circles can have flexible inheritance patterns: [HXT6/7circle] normally segregates

255 id any deleterious effects of unequal genome inheritance, preferential transcription of the plastid d

256 It is believed that biparental inheritance promotes competition between the cytoplasmic

257 around arbitrary conventions like nepotistic inheritance rather than such traits as physical strength

258 e genetic elements that manipulate Mendelian inheritance ratios in their favour.

259 vitro evidence suggested that this compound inheritance resulted in a TBX6 gene dosage of less than

260 It changes the inheritance risk for each pregnancy raising it to 50% an

261 ted with the phenotype of reduced phenotypic inheritance (RPI).

262 , shedding light on socioeconomic processes, inheritance rules, marriage practices and technological

263 e insufficient for counseling, but recessive inheritance should be considered likely in severe early-

264 generally acting to ensure faithful genetic inheritance, SMCs can disrupt genome stability by trappi

265 lized strategies preserving chromatin domain inheritance, specifically the transfer of parental, pre-

266 Inheritance studies in a recombinant inbred line populat

267 us non-memory comparison, and six-generation inheritance studies, identifies gene-associated, heritab

268 es occur as the result of autosomal dominant inheritance, suggesting that WT and mutant subunits asso

269 tify three general features of 'non-genetic' inheritance systems: (i) they are functionally interdepe

270 Ai can lead to trans-generational epigenetic inheritance (TEI) of gene silencing.

271 VMs) are associated with human TBX6 compound inheritance that combines a rare null allele and a commo

272 eflects evolvability, an acquired epigenetic inheritance that may be involved in cancer proliferation

273 ides a platform for understanding oligogenic inheritance that results in clinically relevant OFT malf

274 ely pinpointing aspects of Darwin's views of inheritance that were not supported by Mendel's own expe

275 mutations (usually with autosomal recessive inheritance) that impair ciliary beating cause a variety

276 frequency (>80%) production of non-Mendelian inheritance, the facile and simultaneous homozygosis for

277 elegans not only is H3K9me3 unnecessary for inheritance, the modification's function depends on the

278 trate one such a theoretical framework: dual inheritance theory.

279 nts are genetic dyads that cheat the laws of inheritance to guarantee their transmission to the next

280 e, mean serum Ca concentrations, and mode of inheritance to identify potential FHH1 or ADH1 variants,

281 t on protein function, and predicted mode of inheritance) to identify the causative mutation.

282 oring the molecular underpinnings of genetic inheritance, transcription, the cell cycle, cell death a

283 The grain yield inheritance under optimal condition was largely regulate

284 lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes.

285 ith de novo (n = 8), transmitted (n = 6), or inheritance unknown (n = 2) truncating variants, two ind

286 Among genes with non-Mendelian inheritance, variants in APOL1 have the largest effect s

287 catalyze reactions that regulate epigenetic inheritance via histone post-translational modifications

288 Finally, inheritance was commonly understood to include prior env

289 To understand rose scent inheritance, we characterized a segregating population f

290 cation and genetic analysis of TBX6 compound inheritance, we generated both null and hypomorphic muta

291 into the mechanisms that mediate epigenetic inheritance, we used a Schizosaccharomyces pombe inducib

292 models of chromatin spreading and epigenetic inheritance, we used our system and mathematical models

293 of a genetic element that bypasses Mendelian inheritance which can be used to bias sex determination,

294 self-templating protein-based mechanisms of inheritance whose conformational changes lead to the acq

295 consistent with de novo variants or dominant inheritance with incomplete penetrance as the reason for

296 und a highly polygenic basis of quantitative inheritance, with significant differences in number, eff

297 ion, rare occurrences of asymmetric tetramer inheritance within a heterochromatic domain would have t

298 monas species phylogeny, suggesting vertical inheritance within the genus.

299 n for mutations that abolish heterochromatin inheritance without affecting its establishment.

300 present in an autosomal dominant pattern of inheritance, yet the genetic mechanism has remained elus