ライフサイエンスコーパス: inhibit @1 by

1 o cell uptake was sodium-independent and was inhibited >/=95% by 2-amino-2-norbornanecarboxylic acid

2 I, and these interactions are stimulated and inhibited, respectively, by 2-oxoglutarate, providing a

3 Concentrations inhibiting feeding by 5, 50, and 95% after one day of ex

4 ly inhibited rAAV2 nuclear translocation and inhibited transduction by 50 to 70%.

5 Aged garlic inhibited AGEs by 56.4% compared to 33.5% for an equival

6 techin, quercetin and gallic acid (60mug/ml) inhibited growth by 65.2%, 62.2%, 81.0% and 71.0%, respe

7 uncleaved MA-CA protein into HIV-1 particles inhibited infectivity by ~95%, and the resulting viral p

8 We evaluated their ability to selectively inhibit HDAC6 by a recombinant HDAC enzyme assay, by det

9 This binding was largely inhibited either by a synthetic RGD peptide or by a disr

10 In inside-out patches, currents were inhibited strongly by a combination of diamide/GSH or H(

11 We conclude that FliW inhibits CsrA by a noncompetitive mechanism that differs

12 y a competitive mechanism, whereas verapamil inhibits transport by a non-competitive mechanism, thus

13 formed by the SAC has recently been shown to inhibit Cdc20 by acting as a pseudosubstrate inhibitor,

14 Many neurotransmitters directly inhibit neurons by activating G protein-gated inwardly r

15 ll proliferation in wild-type PC-3 cells and inhibits autophagy by activating mTORC1 effectors eukary

16 The data suggest that blue/green light inhibits proliferation by activating TRPV1, and increasi

17 lysine-reactive fragment electrophiles that inhibit enzymes by active site and allosteric mechanisms

18 In vitro, RGS proteins have been shown to inhibit signaling by agonists at the mu-opioid receptor,

19 Importantly, vanitaracin A inhibited infection by all HBV genotypes tested (genotyp

20 rimary site of infection at least in part by inhibiting phagocytosis by alveolar macrophages.

21 Within 6 h, colonization by the resident inhibited colonization by an isogenic challenger.

22 y gene Nod2 from intestinal abnormalities by inhibiting colonization by an inflammatory Bacteroides s

23 Remarkably, 5-NT also inhibits infection by an alphavirus and a coronavirus.

24 ding of cdb3-PO4 to erythrocyte membranes is inhibited both by antibodies against the SH2 signature s

25 mutant (L858R/T790M, DM EGFR), which is not inhibited selectively by any approved kinase inhibitor.

26 SH3 and SH2 domains inhibit Abl by assembling onto the catalytic domain, all

27 We found that arbidol inhibits infection by authentic LASV, inhibits LASV GP-m

28 ole antifungal drugs showed that CYP126A1 is inhibited strongly by azoles containing an imidazole rin

29 rtilin, a pro-survival molecule, is known to inhibit apoptosis by binding and inhibiting p53, but its

30 e data suggest that the Cu-ATCUN derivatives inhibit bacteria by binding to the membrane, promoting o

31 protein called Glomulin (GLMN) was shown to inhibit CRLs by binding to the RING BOX (RBX1) subunit a

32 exemplifies a class of antiviral agents that inhibit HIV by binding to the highly glycosylated envelo

33 14-3-3 proteins inhibit NR by binding to a conserved phosphorylation sit

34 CBR703 series antimicrobials allosterically inhibit transcription by binding to a conserved alpha he

35 e" model suggests that macrolide antibiotics inhibit translation by binding inside the ribosome tunne

36 hic studies, we demonstrate that MTM and PKM inhibit translation by binding to overlapping sites in t

37 ta suggest that MARV-neutralizing antibodies inhibit virus by binding to infectious virions at the ex

38 AFN-1252 inhibited CtFabI by binding to the FabI.NADH complex wit

39 Using purified proteins, we confirm that RPA inhibits A3A by binding ssDNA, but despite its overexpre

40 s bind in the active site and how ethambutol inhibits arabinosyltransferases by binding to the same s

41 r, but in this paper, we show that Mad2 also inhibits Cdc20 by binding directly to a site required to

42 Liver angiopoietin-like 3 (ANGPTL3) inhibits lipolysis by binding to lipoprotein lipases.

43 r findings suggest that ANGPTL4 specifically inhibits LPL by binding the lid domain, which could prev

44 Together our data suggest that pTRS1 inhibits PKR by binding to conserved amino acids in the

45 We show here that Bmh inhibits transcription by binding to Adr1 at promoters t

46 Here, we show that FMRP inhibits translation by binding directly to the L5 prote

47 s are a suite of aromatic compounds that can inhibit fermentation by biofuel-producing microbes.

48 Abs targeted to VE-cadherin monomers inhibit angiogenesis by blocking this adherens junction

49 V to infect leukocytes, whereas CCR5 ligands inhibit infection by blocking CCR5 engagement with HIV g

50 face E2 glycoproteins and therefore probably inhibit infectivity by blocking the conformational chang

51 Antibodies generally inhibit proteases by blocking substrate access by bindin

52 s, which accumulate following demyelination, inhibit remyelination by blocking the differentiation of

53 Overall, Shenks inhibited fibrosis by blocking TGF-beta pathway and modu

54 onfirms the hypothesis that transport can be inhibited simply by blocking conformational transitions

55 round the receptor-attachment site, probably inhibiting infection by blocking cell attachment.

56 We further demonstrate that inhibiting NETosis by blocking neutrophil elastase or by

57 inal (BET) bromodomain inhibitor, JQ1, which inhibits BRD4 by blocking its association with chromatin

58 These findings suggest that FMRP inhibits translation by blocking the essential component

59 In contrast, NFRKB inhibits UCH37 by blocking the ubiquitin-binding site an

60 In contrast, EBOV VP35 can inhibit activation by both PAMPs.

61 repeat (HRC) domain of HPIV3 F that potently inhibit infection by both HPIV3 and RSV.

62 specifically bound to the RSV fusion bundle inhibited infection by both laboratory and clinical RSV

63 he proliferation of GCase-deficient HSCs was inhibited significantly by both GL1 and Lyso-GL1, sugges

64 Ibogaine noncompetitively inhibited transport by both SERT and the homologous dopa

65 Such stimulatory effect was inhibited, however, by both dominant-negative mutants of

66 , by incorporation of guanosine into poly(A)-inhibits deadenylation by both Pan2 and Caf1.

67 n, rifaximin, and metronidazole) effectively inhibited sporulation by C. difficile.

68 encode messenger RNA endonucleases (mRNases) inhibiting translation by catalytic degradation of mRNA,

69 significantly enhanced thermostability while inhibiting cleavage by cathepsin S, an endosomal proteas

70 d as therapeutic agents for many diseases to inhibit signalling by cell-surface receptors(1).

71 to reveal RNA structures that may naturally inhibit degradation by cellular exonucleases.

72 o results revealed that plaque formation was inhibited/reduced by chlorhexidine and honey rinses.

73 Inhibiting autophagy by chloroquine, bafilomycin, 3-meth

74 ATPase activity and CFTR channel gating were inhibited severely by CL1 peptide, suggesting that NBD1/

75 Here we show that VapC20 of M. tuberculosis inhibits translation by cleavage of the Sarcin-Ricin loo

76 Caspase-10 inhibits autophagy by cleaving the BCL2-interacting prot

77 Here, we show that Gam inhibits RecBCD by competing at the DNA-binding site.

78 f biofilm formation, suggested that HnoX may inhibit colonization by controlling biofilm formation, a

79 Here we show that ALK1 inhibits angiogenesis by cooperating with the Notch path

80 er of Tregs to secondary NOD.scid recipients inhibited autoimmunity by cotransferred NOD effector T c

81 discovery of fosfomycin, which specifically inhibits MurA by covalent modification of the active sit

82 Prolonged NO exposure irreversibly inhibits respiration by covalent modification of mitocho

83 We further found that ferroptosis inducers inhibit GPX4 by covalently targeting the active site sel

84 o Abs from patients with autoimmune diseases inhibit IKr by cross-reacting with the HERG channel like

85 Furthermore, we show that GacB is inhibited directly by cyclic di-GMP, which provides evid

86 on, these genes are believed to additionally inhibit psoriasis by dampening inflammatory signaling in

87 In contrast, activation of ER in ASCs inhibited adipogenesis by decreasing the recruitment of

88 that of Bcl-2, selectively targets VDAC1 and inhibits apoptosis by decreasing VDAC1-mediated Ca(2+) u

89 nt toxins adopt a RelE-family RNase fold and inhibit translation by degrading mRNAs while bound to th

90 Genetic loss of TCF1 inhibited differentiation by delaying exit from pluripot

91 Inhibiting myelination by deletion of Olig2 in oligodend

92 species in the gut epithelium, subsequently inhibiting infection by dengue virus.

93 ha-TE) assays and their in vitro capacity to inhibit ROS by DHE probe.

94 ein (GAP) while YopT is a protease, and they inhibit RhoA by different modes of action.

95 This approach offers a new paradigm to inhibit immunosuppression by direct targeting of MDSC fu

96 Instead, IVIg inhibited phagocytosis by direct blockade of FcgammaRs.

97 have shown that emixustat stereoselectively inhibits RPE65 by direct active site binding.

98 ll lymphoma-X large (Bcl-xL) are proposed to inhibit autophagy by directly binding to the BH3 domain

99 PTP1B inhibited BRK by directly dephosphorylating the Tyr-342

100 Here we find that miR-140-5p inhibits HCC by directly targeting Pin1 to block multipl

101 conclusion, we show that apoC-I and apoC-III inhibit lipolysis by displacing LPL from lipid emulsion

102 ive stress indirectly activates the normally inhibited CypD by displacing it from Trap1 complexes.

103 Here we tested the hypothesis that CRY2 inhibits COP1 by displacing the degradation substrates f

104 in the presence of CRY, nuclear entry of PER inhibits transcription by displacing CLOCK-BMAL1 from th

105 Pheromone exposure inhibits learning by disrupting this balance: it activat

106 HA1 by recruiting PDK1, and K202 acetylation inhibits PDP1 by dissociating its substrate PDHA1, both

107 we show that two Acrs, AcrIIC1 and AcrIIC3, inhibit Cas9 by distinct strategies.

108 res ATP-hydrolysis-powered remodeling of the inhibited complexes by diverse molecular chaperones know

109 In older AVM axons, let-7 inhibits regeneration by down-regulating LIN-41, an impo

110 e thalamocortical cells, but also indirectly inhibit them by driving inhibitory cells of the thalamic

111 ng by Escherichia coli DNA polymerase II and inhibits proofreading by E. coli DNA polymerase III, whi

112 otrypsin phenotype, CTRC variant p.G214R was inhibited poorly by eglin C, ecotin, or a CTRC-specific

113 Functional regulators inhibit motility by either disengaging or jamming the st

114 Mechanistic investigations indicated that inhibiting PARylation by either hyperthermia or PARPi in

115 rotocols and tested for alpha2beta1 integrin-inhibiting capabilities by ELISA.

116 Metformin directly inhibited mTOR by enhancing PRAS40's association with RA

117 AcCoA inhibits autophagy by enhancing EP300-dependent acetylat

118 However, TMB inhibits germination by enhancing ABA levels and reducin

119 ffects on autophagic flux were reproduced or inhibited, respectively, by Epac2 knockdown or activatio

120 he dense chromatin environment is thought to inhibit transcription by excluding transcription factors

121 ng site whose phosphorylation is believed to inhibit YAP by excluding it from the nucleus.

122 Collectively, the data revealed that nsp1 inhibited translation by exerting its effect on multiple

123 nd a side chain crafted to act as a latch to inhibit turnover by fastening down the SULT1A3 active-si

124 ylation of Thr464 present in the CDT2 degron inhibits recognition by FBXO11.

125 ength tau aggregation and are ineffective at inhibiting seeding by full-length fibrils.

126 TP) channels (Sur1(-/-) mice) at G1 could be inhibited further by G7.

127 ignificance as their structural modification inhibits activation by GABA.

128 wever, the molecular mechanism of this STAT3-inhibiting effect by galiellalactone has not been clarif

129 ta by cross-linking it to the EF hand domain inhibits stimulation by Gbetagamma without altering basa

130 ytes and in cultured macrophages showed that inhibiting ACAT1 by gene knockout or by pharmacological

131 Interestingly, inhibiting apoptosis by genetic ablation of TNFr1 signif

132 Of them, 14 drugs inhibited CYP27A1 by >/=75% and were evaluated for in vi

133 e approach for loss-of-function studies that inhibits expression by guiding a transcriptional repress

134 duced by iron or 8-bromo-cAMP was delayed or inhibited, respectively, by H89, the inhibitor of protei

135 e dephosphorylation of OsRBR1 was completely inhibited only by high dose (300 nM) of the okadaic acid

136 sponse, a third effector, YopM, binds to and inhibits pyrin by hijacking PRK and RSK and directing li

137 ides derived from defined regions of HPIV3 F inhibit infection by HPIV3 by interfering with the struc

138 Finally, a blocking antibody against beta8 inhibited immunosuppression by human Tregs in a model of

139 neered single-chain variable fragment (scFv) inhibited seeding by IL15-induced tau oligomers and path

140 Surprisingly, the fibrils inhibited fertilization by immobilizing sperm.

141 Systemic Akt1 deletion inhibits metastasis by impairing survival and mobilizati

142 nd the CAAX box of several small GTPases and inhibits prenylation by impeding their entry into the ge

143 The apoAI mimetic 4F was designed to inhibit atherosclerosis by improving HDL.

144 . (2019) reveal that complement component C4 inhibits adenovirus by inactivating the virus capsid thr

145 Lipid-free apoA-I and (A-I)rHDL inhibit inflammation by increasing DHCR24 expression, wh

146 (AES103 and GBT440) in clinical trials that inhibit polymerization by increasing oxygen affinity, on

147 Many RAPs inhibit transcription by inducing Rho-dependent terminat

148 ults in anti-inflammatory effects capable of inhibiting ACD by inducing immunosuppressive responses.

149 t in early lesion breast cancer models, Her2 inhibits p38 by inducing Skp2 through Akt-mediated phosp

150 In conclusion, our data show that IL-18 may inhibit feeding by inhibiting the activity of BST Type I

151 We demonstrate that biguanides inhibit growth by inhibiting mitochondrial respiratory c

152 at an 'accessory' alpha-helix of Complexin-I inhibits release by inserting into the C-terminus of the

153 hesize that this class of chemical compounds inhibit DNMTs by interacting with the DNA substrate.

154 nt apo(a) variants were able to specifically inhibit HCV by interacting with infectious particles.

155 We conclude that anesthetics inhibit TRPA1 by interacting at a site distinct from the

156 Bim inhibits autophagy by interacting with Beclin 1, an auto

157 he pleckstrin homology (PH) domain of P-REX2 inhibits PTEN by interacting with the catalytic region o

158 HCV pseudoparticles into hepatoma cells and inhibit signaling by interferon alpha (IFNalpha), but ha

159 Forced expression of LNK inhibits signaling by interferon-STAT1 and suppresses in

160 s LPS alone, but neutrophil infiltration was inhibited, likely by interrupting HA-CD44 interaction.

161 III-A*, is a hemostatic enzyme essential for inhibiting fibrinolysis by irreversibly crosslinking fib

162 proteins and cellular p53 and is ultimately inhibited again by its own products.

163 ain region was required for V. vulnificus to inhibit phagocytosis by J774 macrophages, but no single

164 ics but, more importantly, can substantially inhibit recognition by KSHV-specific CD4 T cells prior t

165 ty for both phenology and voltinism, but may inhibit expansion by less flexible species.

166 st active compound identified in the screen, inhibits intoxication by lethal toxin and blocks the ent

167 This pathway is efficiently inhibited only by ligands that occupy both binding sites

168 Lm211 can inhibit Nrg1III by limiting protein kinase A (PKA) activ

169 Rho also inhibits itself by local recruitment of actomyosin and t

170 ation creates a unique hydrogel surface that inhibits recognition by macrophages and fibrous depositi

171 intestinal pathogen, Salmonella Typhimurium, inhibits anorexia by manipulating the gut-brain axis.

172 nd a4 together using isoform-specific siRNAs inhibited invasion by MCF10CA1a cells.

173 ges the Beclin 1-LC8 interaction and thereby inhibits autophagy by mislocalizing Beclin 1 to the dyne

174 oxidative phosphorylation (OXPHOS) in cancer inhibit apoptosis by modulating ROS production and cellu

175 hese results demonstrate that FOXP3(+) Tregs inhibit atherosclerosis by modulating lipoprotein metabo

176 Here, we report for the first time that GNL1 inhibits apoptosis by modulating the expression of Bcl2

177 erefore, in a nucleic acid-driven model, HRG inhibits thrombosis by modulating the intrinsic pathway

178 Rubisco can be rescued from this inhibited form by molecular chaperones belonging to the

179 This finding suggests that Nun may inhibit translocation by more than one mechanism.

180 The ladders were not observed when NER was inhibited either by mouse monoclonal antibody (5F12) to

181 tauopathies tested could be used to broadly inhibit seeding by multiple disease-specific tau polymor

182 esent a class of immunomodulatory drugs that inhibit signaling by multiple cytokines.

183 on RBP recognized by potent human mAbs that inhibit virus by multiple mechanisms.

184 These results indicate that WNK1 inhibits autophagy by multiple mechanisms.

185 work formation, and AKT phosphorylation were inhibited only by murine anti-beta3 integrin antisera an

186 Therefore, versican cleavage can be inhibited substantially by mutation of Glu(441), Ser(507

187 ators of human butyrylcholinesterase (hBChE) inhibited covalently by nerve agent OPs, sarin, cyclosar

188 with canakinumab, a monoclonal antibody that inhibits inflammation by neutralizing interleukin-1beta,

189 ent, significantly delayed diabetes onset by inhibiting infiltration by not only insulin-specific CD4

190 he MAbs could block carbohydrate binding and inhibit hemagglutination by NV rVLP.

191 We show that A238L competitively inhibits CN by occupying a critical substrate recognitio

192 by 87 +/- 10%, HDL dialyzed without calcium inhibited oxidation by only 58 +/- 19% (P=0.004).

193 We then reversibly inhibited V1 by optogenetically activating parvalbumin-e

194 fection are distinct from those required for inhibiting infection by other viruses.

195 Inhibiting EMT by overexpressing the microRNA miR-200 do

196 IV-1 maturation and that small molecules can inhibit maturation by perturbing molecular motions.

197 We generated an antibody that selectively inhibited efferocytosis by phagocytic receptor MerTK.

198 In conclusion, inhibiting SIDS by pharmacological blockade of body's st

199 Thus, both RvE1 and RvD1 receptors directly inhibit LTB4 by phosphorylating the LTB4 receptor using

200 We provide evidence to show that RSK2 inhibits ASK1 by phosphorylating S83, T1109, and T1326 t

201 The AKT kinase, once phosphorylated, inhibits GSK3beta by phosphorylating it at S9.

202 This study tested the hypothesis that cGMP inhibits NHE3 by phosphorylating it and altering its mem

203 ulation of CSPBP in mosquito salivary glands inhibited invasion by Plasmodium organisms.

204 he Nsp1-40S ribosome complex shows that Nsp1 inhibits translation by plugging the mRNA entry channel

205 cognized a quaternary antigenic site and may inhibit fusion by preventing F refolding or by blocking

206 Acetylation of Ser530 inhibits catalysis by preventing access of arachidonic a

207 Inactivation of NCK1 and 2 inhibits polarity by preventing Cdc42 and Pak2 activatio

208 These results indicate that FLCN inhibits tumorigenesis by preventing AMPK-dependent HIF

209 We show that the major effect of 9-1-1 is to inhibit resection by promoting the recruitment of Rad9(5

210 tiation of early-stage cancers, but can also inhibit tumorigenesis by promoting permanent cell growth

211 , under sypG-overexpressing conditions, SypE inhibited biofilms by promoting the phosphorylation of a

212 n the heptamer and (ii) that glycoconjugates inhibited VCC by promoting its assembly to a water-solub

213 and after metabolic stress, and that TAT-p27 inhibits apoptosis by promoting autophagy in glucose-dep

214 The small G protein ARL-8 inhibits assembly by promoting dissociation, while a JNK

215 Overexpression of dnaC inhibits replication by promoting continual rebinding of

216 Dif1 protein inhibits RNR by promoting nuclear import of Rnr2-Rnr4.

217 In conclusion, CsA and FK506 inhibit proteinuria by protecting against PAN-induced po

218 emonstrate that gut epithelial VDR signaling inhibits colitis by protecting the mucosal epithelial ba

219 acteria inhibited S. epidermidis but did not inhibit biofilms by Pseudomonas aeruginosa or Bacillus s

220 First, we demonstrate 5-InsP(7) inhibits decapping by recombinant NUDT3 (Nudix [nucleosi

221 surface receptors found on immune cells and inhibit inflammation by recruiting protein tyrosine phos

222 K321 acetylation inhibits PDHA1 by recruiting PDK1, and K202 acetylation

223 ent; blocking DC synthesis of fatty acids or inhibiting adipogenesis (by reducing endoplasmic reticul

224 miR-375 inhibits autophagy by reducing expression of ATG7 and im

225 alysis and binding assays, we show that Gle1 inhibits Ded1 by reducing its affinity for RNA.

226 ion of virus with soluble Nrp-1 dramatically inhibits infection by reducing virus attachment.

227 Finally, we found that miR-137 inhibits mitophagy by reducing the expression of the mit

228 ely, our results indicate that ceruloplasmin inhibits myeloperoxidase by reducing Compound I and then

229 ylation at another tyrosine residue, Tyr-94, inhibits PDP1 by reducing the binding ability of PDP1 to

230 ASC expression in primary melanoma inhibits tumorigenesis by reducing IKKalpha/beta phospho

231 easing Bax and reducing Bcl-2, but otherwise inhibiting apoptosis by reduction of caspase-3 and cytoc

232 alpha1(IV)NC1 inhibits angiogenesis by regulating MAPK activation, thi

233 We hypothesized that LAT inhibits apoptosis by regulating expression of genes tha

234 kinetic methods, which suggest the compound inhibits Syk by reinforcing the natural regulatory inter

235 We then temporarily inhibited PPC by repetitive transcranial magnetic stimul

236 Here we show that the DEAD-box RBP DDX5 inhibits reprogramming by repressing the expression and

237 AMP and ketone bodies together can therefore inhibit lipogenesis by restricting localization of ChREB

238 [SV5]) interacts with LGP2 and cooperatively inhibits induction by RIG-I ligands.

239 domonas aeruginosa or Bacillus subtilis, and inhibited biofilms by S. aureus to a lesser extent.

240 ssically mediating the kinase arm, PI3Kgamma inhibits PP2A by scaffolding and sequestering, playing a

241 lei to the dorsal hippocampal formation were inhibited, followed by separate inhibition of the dorsal

242 des an endoribonucleolytic toxin, MazF, that inhibits growth by sequence-specific cleavage of single-

243 assical; and whether quinoline antimalarials inhibit crystallization by sequestering hematin in the s

244 using a single domain antibody fragment that inhibits LMO2 by sequestering it in a non-functional for

245 essors of cytokine signaling (SOCS) proteins inhibit signaling by serving as substrate receptors for

246 show that ETS-5 acts to promote roaming and inhibit quiescence by setting the internal "satiety quot

247 tudies showed that TSPAN9 depletion strongly inhibited infection by several viruses that fuse in earl

248 crobes provide signals that both promote and inhibit autoimmunity by signaling through different rece

249 The plasmid inhibits transformation by simultaneously silencing the

250 omain endonucleases that, in enterobacteria, inhibit translation by site-specific cleavage of initiat

251 In contrast, VapC20 of M. tuberculosis inhibits translation by site-specific cleavage of the un

252 m LT2 encodes VapC, a tRNase that reversibly inhibits translation by site-specific cleavage of tRNA(f

253 discovered that elevated levels of c-di-GMP inhibit swarming by skewing stator selection in favor of

254 It was found that CaCO(3) crystal growth was inhibited mostly by soluble starch by forming starch-Ca(

255 These pathways can either promote or inhibit colonization by specific subsets of commensal ba

256 Each compass neuron is inhibited only by specific visual cue positions, indicat

257 onmental stress, the phosphatase calcineurin inhibits Hcm1 by specifically removing activating phosph

258 o and in vivo experiments, we found that IgG inhibits motility by specifically binding to the O-antig

259 ficient mice, suggesting that endogenous LPM inhibit differentiation by SPM.

260 that volatile anesthetics such as isoflurane inhibit NaV by stabilizing the inactivated state or alte

261 ucleic acids crosslinking suggests that NusG inhibits backtracking by stabilizing the minimal transcr

262 of cADPR-binds only to the MHR1/2 domain and inhibits TRPM2 by stabilizing the channel in an apo-like

263 some of the clonally expanded CD8(+) T cells inhibit disease by suppressing the proliferation of MOG-

264 Mechanistically, CS and SULT2B1b inhibited gluconeogenesis by suppressing the expression

265 KCa3.1 blockade or knockdown inhibited proliferation by suppressing the rise in [Ca(2

266 d illustrate a spinal mechanism whereby pain inhibits itch by suppressing the function of GRPR neuron

267 Intriguingly, Deltex2 inhibits myogenesis by suppressing MyoD transcription, a

268 antagonizes spreading in two ways: directly inhibiting catalysis by Suv39/Clr4 and locally disruptin

269 The T3-specific antibody inhibited hemagglutination by T3 virions but not ISVPs,

270 r, and was suppressed when ER signalling was inhibited either by tamoxifen in vitro or letrozole in h

271 results support the idea that antisense RNAs inhibit retrotransposition by targeting Ty1 protein func

272 CS and SULT2B1b inhibited gluconeogenesis by targeting the gluconeogenic

273 Our study suggests that inhibiting glycolysis by targeting Gpi1 could be an effe

274 pression of miR-503 promotes cell growth and inhibits apoptosis by targeting PDCD4.

275 d a benzodiazepine compound that selectively inhibits YFV by targeting the viral NS4B protein.

276 establish that yeast sHsps, Hsp26 and Hsp42, inhibit prionogenesis by the [PSI+] prion protein, Sup35

277 mal targeting and secretion of mHtt could be inhibited efficiently by the phosphatidylinositol 3-kina

278 Netrin-1-induced JNK activation was inhibited either by the JNK inhibitor or an anti-DCC fun

279 e to a broad range of H7 subtype viruses and inhibited hemagglutination by the novel H7 hemagglutinin

280 n A and other high affinity ligands directly inhibited signaling by the low affinity ligands BMP-2, B

281 ceptor and GRP-BB2 receptor systems and itch-inhibiting effects by the dynorphin A-KOP receptor syste

282 pancreatic ductal adenocarcinoma (PDAC) that inhibiting signaling by the myeloid growth factor recept

283 protein, IRE1beta diminishes expression and inhibits signaling by the closely related stress sensor

284 , demonstrating the therapeutic potential of inhibiting USP7 by this approach.

285 platin-resistant human ovarian cancer cells, inhibiting IDO by transcriptional deregulation of the au

286 ns to inhibit ADK, while AL2 in addition can inhibit silencing by transcriptionally activating cellul

287 t, during Hedgehog signaling, ligand binding inhibits Patched by trapping it in an inactive conformat

288 We inhibited STAT5 by treating Mo-DCs with JQ1, a selective

289 cytoplasmic or luminal sides of the membrane inhibited RyR2 by two distinct modes: 1) a fast block co

290 ween the prodomain and catalytic domain, and inhibits MMP9 by two mechanisms.

291 We conclude that isoflurane inhibits NaChBac by two distinct mechanisms: (i) as a ch

292 REL1) belongs to "other" subfamily HECT that inhibits apoptosis by ubiquitinating and degrading proap

293 Salmonella enterica was previously shown to inhibit growth by unknown mechanisms.

294 molecules p21 and p27, whereas IFN-gamma may inhibit proliferation by up-regulating antiproliferative

295 UB1-2 domains not only bound MDTCS, but also inhibited activity by up to 2.5-fold.

296 Mang-NPs also inhibited EMT by up-regulating E-cadherin and inhibiting

297 The T1-specific antibody inhibited hemagglutination by virions and ISVPs, probabl

298 ne cholesterol with methyl-beta-cyclodextrin inhibited infection by virions but had no effect when in

299 the principal reproductive(s) of a colony to inhibit reproduction by worker colony members.

300 se inhibitors, we analyzed structures of the inhibited protease by X-ray crystallography.