ライフサイエンスコーパス: inhibition by

1 s in HeLa cells, which are more sensitive to inhibition by 1 in the presence of the glycolysis inhibi

2 The degree of inhibition by 100 uM A2764 (77.8% +/- 3.5%, n = 6) was l

3 a demonstrate the stereoselectivity of NMDAR inhibition by (2R,6R;2S,6S)-HNK and support the conclusi

4 rate specificity, allosteric regulation, and inhibition by a class of small molecules that are curren

5 This preservation of inhibition by a disinhibitory motif arises from the inte

6 293T cells suggest that selective PS1 or PS2 inhibition by a given GSI does not explain the previousl

7 osteoclastogenesis, while its pharmaceutical inhibition by a monoclonal antibody has been approved fo

8 the current study, our data showed that JNK1 inhibition by a pharmacological inhibitor or RNA interfe

9 tion and symmetric dimethylation after PRMT5 inhibition by a selective inhibitor.

10 atic IEC turnover, whereas Gpr35 deletion or inhibition by a selective pepducin prevented inflammatio

11 Here we report that p300/CBP inhibition by a small molecule p300/CBP inhibitor dramat

12 rentially selected the HR1 pathway to escape inhibition by a trimer-stabilized HR1 peptide.

13 copy of the pharmacological effects of PIP4K inhibition by a131.

14 uced genome editing by AcrIIA13 and moderate inhibition by AcrIIA14 and AcrIIA15.

15 rences in the temperature dependence of Cas9 inhibition by AcrIIA2 and AcrIIA2b arise from difference

16 models of breast cancer increases checkpoint inhibition by activating antigen-presenting cells, enhan

17 In contrast, TamR cells respond to OGT inhibition by activating the unfolded protein response a

18 aluate the antiarrhythmic efficacy of TASK-1 inhibition by adeno-associated viral anti-TASK-1-siRNA (

19 f hENT1-mediated adenosine transport and its inhibition by AdoRIs are limited, owing to the absence o

20 contributing to their relative resistance to inhibition by AE.

21 Taken together, pan-EGFR inhibition by afatinib impedes PCSCs growth and metastas

22 nterface and conferred sensitivity to kinase inhibition by afatinib.

23 field, certain enzymes remain refractory to inhibition by agents recently introduced.

24 induced by amyloidogenic peptides and their inhibition by aggregation modulators.

25 mary reason for the disparity is nonspecific inhibition by aggregation.

26 point mutations that: 1) mimicked allosteric inhibition by alanine, 2) mimicked inhibition by protein

27 caused reduced inhibition or highly reduced inhibition by all NA inhibitors.

28 Lipase inhibition by all smoothies was over 50%.

29 show that genetic depletion of AURKA, or its inhibition by allosteric but not catalytic inhibitors, b

30 ntially allowing assessment of direct enzyme inhibition by almost any compound.

31 ble aggregate-bound plasmin is shielded from inhibition by alpha2-antiplasmin and degrades amorphous

32 Importantly, inhibition by alphaSNAP is avoided only when Munc18-1 bi

33 However, distinct mechanisms of inhibition by alphaSNAP were suggested, and it is unknow

34 binding to the channel enhances PF-05089771 inhibition by altering the equilibrium between resting s

35 za strains varied in their susceptibility to inhibition by AM-EVs.

36 droxyl reactivity can contribute to protease inhibition by an alphaM protein.

37 ev-erbalpha activity attenuates, whereas its inhibition by an antagonist promotes these processes.

38 or the second heptad repeat (HR2), to escape inhibition by an HR1 peptide, but preferentially selecte

39 Whether stronger platelet inhibition by an intensified oral loading strategy (ILS)

40 Pharmacological inhibition by an L-type VGCC specific blocker, or limb-s

41 f enzymatically active LPL by preventing its inhibition by angiopoietin-like protein 4 (ANGPTL4).

42 This inhibition by anionic membranes could be a potential mec

43 ons in many cancers, sensitize cells to PARP inhibition by antagonizing histone demethylation and obs

44 support virus entry and on susceptibility to inhibition by antibodies and small molecules.

45 surface Env recognition and cell-cell fusion inhibition by antibodies differed for the DS Env and the

46 for exploring mechanisms of virus infection inhibition by antibodies.

47 ral basis of the mechanism underlying fusion inhibition by Arbidol has remained obscure, thereby hind

48 ct binding sites raises the possibility that inhibition by aryl sulfonamides and by classic local ane

49 atelets by anti-CD41 mAb treatment, platelet inhibition by aspirin, and adoptive transfer of wild-typ

50 s conferred either reduced or highly reduced inhibition by at least 1 NA inhibitor; half of them caus

51 atrix domain of Cox5A-involved in allosteric inhibition by ATP-may arise from its association with CI

52 II in isolated mitochondria: (a) complex II inhibition by atpenin A5 or complex III inhibition by st

53 Either CaMKII-inhibition (by autocamtide-2-related peptide) or IP(3)R-

54 h Cf-2 and Avr2 when engineered for enhanced inhibition by Avr2.

55 o-culture challenge assays, we quantified Bd inhibition by bacterial isolates collected from the skin

56 iol reactivity; however, we propose that PDI inhibition by BAP2 analogues depends on the b' domain.

57 and mechanistic studies of the radical chain inhibition by BHT (butylated hydroxytoluene).

58 Consistently, GSK-3beta inhibition by BIO-acetoxime infusion or GSK-3beta knockd

59 rolases are susceptible to potent reversible inhibition by boronic acids.

60 tures reveal that activation and competitive inhibition by both GluN1 and GluN2 antagonists occur by

61 de a pathway for activation and for feedback inhibition by branched-chain amino acids.

62 The inhibition by bupropion was reversible and time-dependen

63 he two extracellular loops abrogates channel inhibition by carbenoxolone.

64 basis of tissue-specific enzyme activity and inhibition by catalytic products, Hans Krebs first demon

65 s of RECON activity, via genetic ablation or inhibition by cdNs, increased NF-kappaB activation and r

66 first and decitabine was escalated once CDA inhibition by cedazuridine approached the maximum effect

67 HIV-1 replication in human macrophages from inhibition by cGAMP, the product of activated cGAS.

68 lack the PAS domain show significantly lower inhibition by CH, suggesting that CH affects currents fr

69 nterneurons is enhanced, whereas perisomatic inhibition by cholecystokinin-expressing interneurons is

70 t cortical neurons and markedly overcame the inhibition by chondroitin sulfate proteoglycans and matu

71 nt" increase in DNA damage resulting from HR inhibition by cisplatin/Nutlin-3.

72 of this study was to investigate if platelet inhibition by clopidogrel has a functionally relevant in

73 the capacity for voltage-dependent G-protein inhibition by co-expressed Trichoplax Gbetagamma subunit

74 PCNA inhibition by competing peptides or by T2AA, a small-mol

75 reveals the importance of avoiding ribozyme inhibition by complementary oligonucleotides.

76 ; the structural bases for NAAA function and inhibition by covalent and noncovalent agents; and final

77 DPAGT1 inhibition by CPPB leads to a reduced expression level o

78 lignant compared with healthy tissue and its inhibition by CX-6258 had minimal toxicity in ex vivo-ex

79 HASPIN inhibition by CX-6258 is a novel and potent strategy for

80 ty forms the basis of cellular excitation or inhibition by Cys-loop ligand-gated ion channels (LGICs)

81 l sirtuins Sirt3 and Sirt5 were resistant to inhibition by cysteine oxidants.

82 ependence of the pumping rate and a stronger inhibition by cytoplasmic K(+) than the WT enzyme, which

83 TRPM8 activity and sensitizes the channel to inhibition by decreased levels of its cofactor, PI(4,5)P

84 thway likely enables GCs to regulate lateral inhibition by defining time windows when lateral inhibit

85 reviously been shown to be controlled by cis-inhibition by Delta in the follicle cells, which is reli

86 The direct inhibition of GPX4, or indirect inhibition by depletion of its substrate glutathione or

87 ed for its interfacial activation as well as inhibition by detergent micelles and lipoprotein particl

88 BA response maturation depends on release of inhibition by developmentally regulated diffusible signa

89 nt for both enzyme activity and the feedback inhibition by DHNA.

90 susceptible and resistant strains with their inhibition by different beta-lactams.

91 We tested UT inhibition by dimethylthiourea (DMTU) in 5/6 nephrectomy

92 In this study, we revisited the mechanism of inhibition by diminazene and its binding site on ASIC1a,

93 Specific CDK inhibition by dinaciclib and palbociclib decreases PASMC

94 nsible for glycolysis-mediated RLR signaling inhibition by directly binding to MAVS transmembrane (TM

95 e an alternative therapeutic approach for AR inhibition by disruption of FOXA1 function, which may be

96 R1 from Tric-a KO mice are more sensitive to inhibition by divalent cations, although they respond no

97 ellagic acid did not alter the tumor growth inhibition by docetaxel of xenografted 22Rv1 cells, ella

98 Its dysfunction or inhibition by drugs can cause severe, chronic liver dise

99 Piezo2 inhibition by drugs or molecular knockdown decreases mec

100 T We describe a novel pathway, consisting of inhibition by dynorphin, somatostatin, and corticotropin

101 , wherein DNA-PK is required for ATM and ATR inhibition by E4orf4 earlier during infection but is inh

102 he type I IFN signaling pathway targeted for inhibition by EHV-1.

103 TG2 inhibition by either a viral particle or pharmacological

104 aw no difference in binding or degree of LTP inhibition by either Abeta or tau oligomers between sham

105 train PCC6803 and observed a redox-dependent inhibition by either artificial reducing agents or TRXo1

106 Mechanistic target of rapamycin inhibition by either nutrient starvation or use of an ac

107 lly primes PDAC tumors for immune checkpoint inhibition by enhancing antigen presentation only follow

108 lue, which limits adaptive resistance to MEK inhibition by enhancing interfacial binding.

109 ll MRTs, sensitized cells to MDM2 and MDM2/4 inhibition by enhancing p53-mediated apoptosis.

110 luR1 increases the strength of this efferent inhibition by enhancing the presynaptic release of acety

111 tizes enzalutamide-resistant cells to growth inhibition by enzalutamide.

112 ch sequesters free Gbetagamma protein, TRPM3 inhibition by EP2 and BK2 was significantly reduced.

113 that protons interfere with allosteric ENaC inhibition by extracellular sodium ions, thereby increas

114 fer proton-sensitivity and enable allosteric inhibition by extracellular sodium ions.

115 Inhibition by (-)-fenchone and six structurally related

116 partial resistance to STAT3 transcriptional inhibition by FK228 (P <= 0.0024).

117 els in vitro, reports have claimed that RyR2 inhibition by flecainide is not relevant for its mechani

118 wo reporter genes allows monitoring of viral inhibition by fluorescence or bioluminescence, overcomin

119 to produce higher current densities suggest inhibition by formation of pH, nutrient, or redox potent

120 n, and sensitized RAS-mutant cells to growth inhibition by FTI.

121 Tumor growth inhibition by full thickness excisional wounds was dose-

122 We show a broad spectrum of fusion inhibition by GA of all three classes of fusion proteins

123 homozygote mice exhibited normal presynaptic inhibition by GABA(B) receptors, which inhibit VGCCs, bu

124 or calcium-calmodulin kinase II (CaMKII) and inhibition by Galphai/o, novel PKC isoforms, or calcium-

125 resting conditions due to significant, tonic inhibition by gamma-aminobutyric acid (GABA).

126 nstrate that TRPM3 is subject to promiscuous inhibition by Gbetagamma protein in heterologous express

127 1) that are individually necessary for TRPM3 inhibition by Gbetagamma.

128 n that desensitizes the enzyme to allosteric inhibition by GDP/GTP.

129 es their invasion and migration, whereas its inhibition by genetic approach, but not by pharmacologic

130 Sodium channel inhibition by GS-967 and eleclazine has unique effects,

131 age from the anterior eye showed significant inhibition by GsMTx4.

132 ange by >70-fold, and mitigating host growth inhibition by >20%.

133 se in sensitivity of these viral products to inhibition by guanidine hydrochloride (GuHCl) (which tar

134 Since protein kinase A inhibition by H-89 and knockdown of beta-arrestin 1 or b

135 Our results confirm direct transcriptional inhibition by H1 and establish a gene-specific H1 evicti

136 e" complex formation and overcomes catalytic inhibition by halide ions.

137 on by autophagy-inducing BECN1 peptides, and inhibition by HIV-1 Nef are mediated by the switchable a

138 vity in patients and their susceptibility to inhibition by host-targeted drugs are unknown.

139 f caspase-1 by NLRC4-H443P is due to loss of inhibition by HSC70.

140 2,9-Me(2)-phen ligand but accompanying rapid inhibition by hydrogen.

141 glomus cells expressing K(+) channels whose inhibition by hypoxia leads to transmitter release and a

142 with resistance to Bruton's tyrosine kinase inhibition by ibrutinib in both chronic lymphocytic leuk

143 ich is insensitive to Bruton tyrosine kinase inhibition by ibrutinib, and the activated B-cell (ABC)

144 thermore, a compound which counteracts virus inhibition by IFITM3, Amphotericin B, prevented the IFIT

145 ns signalling potential but is impervious to inhibition by IL-18BP.

146 d further sensitized Ba/F3 BCR-ABL1 cells to inhibition by imatinib, while demonstrating no toxicity

147 he wastewater discharge, and denitrification inhibition by impacted creek water was clearly observed

148 of the K24G mutant became more sensitive to inhibition by increasing pH.

149 Thus, growth inhibition by individual drugs and combinations was asse

150 remarkably effective and sub-stoichiometric inhibition by interacting not with the monomeric unfolde

151 on the ICP0 gene (0DeltaNLS) is sensitive to inhibition by interferon beta (IFN-beta) in vitro and fu

152 e to (a) unleash antitumor immune cells from inhibition by intracellular cAMP and (b) prevent immunos

153 so shown that silencing TRPC4 in DRG and its inhibition by intradermal injections were also effective

154 duced by glucosamine were susceptible to the inhibition by iron, but in the case of OGT inhibition, i

155 d the impact of activating donor KIR2DS1 and inhibition by KIR3DL1 separately but found no significan

156 Pharmacological ATM inhibition by KU55933 in cisplatin-treated mice did not

157 Furthermore, inhibition by lacosamide was greatly reduced by pretreat

158 While viral adhesion inhibition by large polymeric molecules has proven viabl

159 mics approaches, we show that intestinal Wnt inhibition by Lats deletion is Yes-associated protein (Y

160 The SERT inhibition by Lu AF60097 is demonstrated by the potentia

161 as accelerated in older mice on FFD, and Shc inhibition by LV in older mice or hepatocyte-specific de

162 n trophoblasts in conjunction with autophagy inhibition by lysosomal impairment.

163 The molecular mechanism of inhibition by M. tuberculosis involves reduced phosphory

164 (50) 1.2 mM), and 5AMF (IC(50) ~3 mM) but no inhibition by M5NF.

165 TRIP13 and p31(comet) prevent APC/C inhibition by MCC components, but cannot reactivate APC/

166 xplore the possible mechanisms of HIF-1alpha inhibition by MeHg.

167 and that Zeo1.b itself was hypersensitive to inhibition by MeJA but less responsive to promotion by g

168 icant insights into the effects of metabolic inhibition by metformin + 2-DG treatment on primary huma

169 MYBL1 3'UTR inhibition by miR-221/222 was lost by deletion of a sing

170 ts showed mechanical activation of NMDAR and inhibition by MK-801.

171 However, a reduction in the inhibition by morphine for DOP-/- c.f. WT neurons and a

172 The mechanism of HCV inhibition by Mov10 is unknown.

173 gist mutants were more susceptible to growth inhibition by murine and human macrophages activated wit

174 copies of the acidic domain is resistant to inhibition by mutant p53 and efficiently promotes mutant

175 complex relieves NadE(Gln) negative feedback inhibition by NAD(+) This mechanism is conserved in dist

176 yrophosphate by-product, and blunts feedback inhibition by NAD(+).

177 ac1 deletion in SMCs or pharmacological Rac1 inhibition by nebulization of NSC23766 prevented AHR in

178 these data support a mutagenic mechanism of inhibition by NHC and further support the development of

179 echanisms accounting for NF-kappaB signaling inhibition by NO2-OA in TNBC cells were multifaceted, as

180 iRNA knockdown of DPP6 antagonized the I(to) inhibition by NS5806 in hiPSC-CMs.

181 ATP12A inhibition by ouabain decreased bacterial proliferation.

182 ction (i.e. CdCl(2) toxicity versus ion pump inhibition by ouabain), a significant advance against st

183 test system causing microbial starvation or inhibition by P release.

184 al repressor, suppresses the effects of EGFR inhibition by partially restoring the EGFR-promoted gene

185 BK inhibition by PAX is best characterized by the idea that

186 possibility by examining the state-dependent inhibition by PF-05089771 and lidocaine of human Nav1.7

187 nactivated state under drug-free conditions, inhibition by PF-05089771 was both enhanced and speeded

188 changes previously identified for allosteric inhibition by Phe.

189 surface receptor signalling, termed receptor inhibition by phosphatase recruitment (RIPR).

190 as a key downstream target of Rig-G, and p53 inhibition by pifithrin-alpha caused abrogation of tumor

191 rthered our understanding of how HCMV evades inhibition by PKR and identified new strategies for how

192 xclusively be attributed to Ile-Trp, the ACE inhibition by plant protein hydrolysates is caused by a

193 ve studies included analysis of in vivo FLT3 inhibition by plasma inhibitory activity assay and indic

194 tural changes and motions that relieve SERCA inhibition by PLB.

195 omet) had a greatly decreased sensitivity to inhibition by Plk1 of its action to disassemble mitotic

196 iculum calcium pump (SERCA) by relieving its inhibition by PLN.

197 Here, we show that CSF1R inhibition by PLX5622 indeed affects the myeloid and lym

198 WIK-1 retention in intracellular organelles, inhibition by posttranslational sumoylation, a hydrophob

199 nt guidelines recommend intensified platelet inhibition by prasugrel or ticagrelor in patients with u

200 disease, this general approach to enzymatic inhibition by preventing access to specific subcellular

201 To confirm that adhE is the cause of inhibition by primary alcohols, we showed that deleting

202 llosteric inhibition by alanine, 2) mimicked inhibition by protein phosphorylation, and 3) prevented

203 s SET, we investigated a role for SET in DDR inhibition by protein VII.

204 ist-gating and subunit-dependent competitive inhibition by providing multiple structures in distinct

205 protein Smoothened (SMO) is released of its inhibition by PTCH1 and accumulates in cilia.

206 mportant for activation by PtdIns(3,5)P2 and inhibition by PtdIns(4,5)P2.

207 strate responsiveness to ATP application and inhibitions by purinergic receptor antagonists, whole ce

208 uction of DNA double-strand breaks or mTORC1 inhibition by rapamycin results in reduced levels of HMO

209 m contributes to the homeostasis of synaptic inhibition by rapidly adjusting neuronal [Cl(-)]i to GAB

210 r was also more resistant than homodimers to inhibition by RD3.

211 that culture GEO12CF may overcome chloroform inhibition by rdh upregulation.

212 ich inhibit VGCCs, but defective presynaptic inhibition by receptors that work directly on the SNARE

213 ration and then measured corollary discharge inhibition by recording evoked potentials from midbrain

214 s similar to Makona in its susceptibility to inhibition by remdesivir and to neutralisation by monocl

215 indicate that MpFRH1 miRNA mediates lateral inhibition by repressing MpRSL1 during pattern formation

216 anced T(H)9 differentiation, even with STAT3 inhibition, by restoring suppressor of cytokine signalin

217 dependence of the G86R GCAP1-RetGC1 complex inhibition by retinal degeneration 3 (RD3) protein was s

218 Importantly, PI3K/Akt inhibition by Rictor/mTORC2 deletion blocks distant disp

219 Therefore, we investigated effects of FXa inhibition by rivaroxaban on both newly-formed and pre-e

220 Cdk5 inhibition by roscovitine infusion prevented depressive-

221 csin C-insensitive pathway and the increased inhibition by rosiglitazone G confirmed the sensitivity

222 hondrial NADH/NAD state similar to Complex 1 inhibition by rotenone.

223 To evaluate a possible inhibition by RSV, we subjected RSV-inoculated AB mDC to

224 This mutant allowed separation of the UPR inhibition by RTA from cytotoxicity because it reduced t

225 The observations explain how PI3KC3 inhibition by Rubicon, activation by autophagy-inducing

226 which is the first report of Sirt2 and Sirt6 inhibition by S-nitrosation.

227 orm of MTHFR is more sensitive to allosteric inhibition by SAM.

228 elucidate the mechanism of host translation inhibition by SARS-CoV-2 and advance understanding of th

229 eptors CDON/BOC and GAS1, which relieves SHH inhibition by SCUBE.

230 cytosolic protein implicated in axon growth inhibition by Semaphorin/Plexin complexes.

231 network dynamics of the recruitment of local inhibition by sensory input.

232 We show that transient apoptosis inhibition by short-term overexpression of prosurvival B

233 This inhibition by SidJ is spatially restricted in host cells

234 These results indicate that MEV cascade inhibition by simvastatin induced the intrinsic apoptosi

235 Sortilin inhibition by siRNA and the pharmacologic inhibitor AF38

236 WL229, a specific Ces3 inhibitor, or genetic inhibition by siRNA to Ces3 on isoproterenol (ISO)-treat

237 r of CDPK1 makes it exquisitely sensitive to inhibition by small molecule 1H-pyrazolo[3,4-d]pyrimidin

238 apeutic targets through either activation or inhibition by small molecules.

239 alidated by site-directed mutagenesis and by inhibition by small peptides that mimic the loop residue

240 For this reason, the PCSK9 inhibition, by small molecules or peptides, is a validat

241 sprayed homogeneously on the plate, and PSII-inhibition by specific sample components is detected bas

242 Not only subjected to growth inhibition by spermine, the pauA2 mutant became more sen

243 Mevalonate pathway inhibition by statins blocked pyrimidine nucleotide bios

244 monstrate that the efficiency of prenylation inhibition by statins is Ggamma subtype-dependent and is

245 x II inhibition by atpenin A5 or complex III inhibition by stigmatellin that results in succinate-dep

246 ent data show that DA release is under tonic inhibition by striatal GABA.

247 ession can remain inhibited and sensitive to inhibition by strigolactone.

248 In some cases, ribosome standby can overcome inhibition by structure: 30S subunits bind sequence-nons

249 deepen our understanding of prazole budding inhibition by studying a range of viruses in the presenc

250 FGFR2 inhibition by SU5402 impacts a significant fraction of t

251 d shoot Se accumulation and less competitive inhibition by sulfate or by high-S pretreatment.

252 VAMP8(-/-) acini are resistant to secretory inhibition by supramaximal CCK-8, and despite a 4.5-fold

253 chemical framework for selective ERK pathway inhibition by targeting the SHOC2 holophosphatase.

254 bined results reveal the potential for KDM5B inhibition by TCA cycle intermediates, but suggest that

255 ntly escape the slow kinetics of Kunitz-type inhibition by TF pathway inhibitor and preferentially ac

256 rapsyn-clustered AChR currents, and current inhibition by the AChR-Ab positive sera was greater when

257 Pharmacological inhibition by the antioxidant NAC (N-acetyl cysteine) pr

258 Alanine scanning revealed decreased inhibition by the aptamer for mutants P420A, L422A and K

259 Furthermore, Cxcr3.2 inhibition by the chemical antagonists AMG487 and NBI-74

260 omic and proteomic profiling of CREBBP/EP300 inhibition by the chemical probe SGC-CBP30 identified co

261 illustrated by its vulnerability to chemical inhibition by the clinical drug candidate Q203 and sever

262 lts, we analyze the structural basis of KLK7 inhibition by the covalent attachment of aromatic coumar

263 Fusion inhibition by the GAP Gyp1-46 is not limited to Ypt7-tm

264 the same key HR1 or HR2 mutations to escape inhibition by the HR1 peptide but different combinations

265 esistance pathways as the R5 virus to escape inhibition by the HR1 peptide.

266 Auto-inhibition by the KA1 domain functions in parallel with

267 endothelial cells and contributes to I(SOC) inhibition by the PPP5C-FKBP51 axis.

268 and indicate that the catalyst is subject to inhibition by the product of the chloroacylation reactio

269 Catalyst inhibition by the pyranoside sulfate product and trialky

270 ted by cAMP-Crp signalling but also requires inhibition by the regulator fructose 1,6-bisphosphate, w

271 ay, Acinetobacter baumannii, is resistant to inhibition by the relevant intermediate, suggesting that

272 investigated the mechanism of Kif18A and its inhibition by the small molecule BTB-1.

273 alance, and mitochondrial function after GLS inhibition by the small molecule currently in clinical t

274 y pressure myography, were very sensitive to inhibition by the SUR2-specific K(ATP) channel activator

275 n between protein flexibility and potency of inhibition by the TDZD 4-[(4- fluorophenyl)methyl]-2-(4-

276 ated rare variant (M2145T) in TGEF2 impaired inhibition by the TGEF2 pleckstrin-homology domain, resu

277 selected a unique mutation in HR2 to escape inhibition by the trimer-stabilized peptide.

278 tablish the structural basis of differential inhibition by the widely used Wee1 inhibitor MK-1775.

279 ng in cancer that would not be accessible to inhibition by therapeutic antibodies.

280 agonists, indicating that the sensitivity of inhibition by these molecules may be modulated by Env co

281 sheds light on the future studies into UBE2N inhibition by this modification and deubiquitinases of t

282 l insights into the structural basis of AKT1 inhibition by this unique class of compounds.

283 The inhibition by trans addition of alcohols implies that th

284 nthesis, reduction of GluTR activity through inhibition by tRNA(Glu) precursors causes tetrapyrrole s

285 We also evaluated SRM inhibition by tungstate in advective upflow oil-sand-pac

286 chemistry of the synergistic crystal growth inhibition by two inhibitors.

287 The CPS was used to control urea hydrolysis inhibition by two logics: (1) reactively responding to a

288 we show that the mechanism of transdominant inhibition by uncleavable Gag involves inhibition of nuc

289 ncer (TNBC) cell lines, which respond to OGT inhibition by undergoing cell cycle arrest and apoptosis

290 butes to CD8(+) T cell-mediated tumor growth inhibition by unleashing inflammasome activation.

291 ion of NRAS or combination MEK1/2 and CDK4/6 inhibition by upregulating activity of the RTK-RAS-RAF a

292 Their dominant response was inhibition by valueless objects, which generated disinhi

293 h at a level on par with the level of growth inhibition by vancomycin.

294 VEGFR1 inhibition by VEGF(165)b results in S100A8/S100A9-mediat

295 induction, is the major cause of cell growth inhibition by viomycin.

296 Here, we investigated the mechanism of inhibition by VIR165.

297 privileged pharmacophores for PI3K and PIKKs inhibition by virtue of the morpholine oxygen, both form

298 This study demonstrates denitrification inhibition by wastewater discharge from a poultry proces

299 Tumor inhibition by wound was unaffected by presence of an imm

300 that gain of function MEFV mutations bypass inhibition by YopM.