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3 e essence of the model is that intracortical inhibition of a direction-selective cell is spatially in
4 o the molecular mechanism of drug export and inhibition of a major multidrug efflux pump and the dire
6 riven by significantly selective (>100-fold) inhibition of a subset of the eight bromodomains is enti
7 SNI-1 enhances chemotherapy-dependent growth inhibition of a variety of cancer cells, including human
9 on of an actin regulator, by pharmacological inhibition of actin polymerization, and by the expressio
10 ty in migrating cells rapidly decreases upon inhibition of actomyosin contractility (specifically, of
15 Here we have systematically studied Zn(2+) inhibition of AMPARs by varying calcium permeability, au
18 lin-dependent kinase 12 (CDK12) or selective inhibition of an analog-sensitive CDK12 reduces DNA dama
20 trate that RUNX3 plays a pivotal role in the inhibition of apoptosis found in the beta-catenin S45F m
21 n liver injury, and provide evidence for mAb inhibition of AQP3-mediated H(2)O(2) transport as therap
22 e term "pull-away" and "search-and-capture." Inhibition of Arp2/3 complex inhibits TMT assembly by bo
23 ion murine model, T1317-sHDL showed superior inhibition of atherogenesis and reduced hypertriglycerid
24 the intestinal epithelium or pharmacological inhibition of ATM, YAP1, or caspase-1 as well as antibio
26 revealed 9-dechlorochrysophaentins leads to inhibition of bacterial cell wall biosynthesis by disass
27 nteraction provide a mechanism for efficient inhibition of beta-catenin phosphorylation upon Axin rec
32 sibly through NADPH depletion and subsequent inhibition of BMI1, an integral component of polycomb-re
35 uice provoked induction of several genes and inhibition of both CYP3A4 and CYP1A2, matching effects o
36 Furthermore, the study shows that combined inhibition of both EGFR and STAT3 might overcome drug re
37 ibits Herpes simplex virus type 1 (HSV-1) by inhibition of both fusion and viral protein synthesis.
43 ch in Orai1-STIM stoichiometry, resulting in inhibition of Ca2+ entry and Ca2+-dependent gene express
45 ial) decrease sensitivity to opioid-mediated inhibition of cAMP and promote hyperactivity of nocicept
46 To define the physical basis for EapH1's inhibition of cathepsin-G, we crystallized EapH1 bound t
47 sion, this approach based on the concomitant inhibition of CB1R and iNOS represents a promising thera
52 ntriguingly, both optogenetic excitation and inhibition of cerebellar cortical output neurons, Purkin
53 e hypothesis that genetic or pharmacological inhibition of CETP would preserve high-density lipoprote
54 lines of research that demonstrate chemical inhibition of cholesterol biosynthesis compromises neuro
57 h AB1 show that the irreversible competitive inhibition of CLK1 is dependent on a Michael acceptor fo
59 pe VGCC isoform was required for ACh-induced inhibition of contraction, a mechanism by which those ch
60 stablished the eicosanoid profiles linked to inhibition of COX-1 in platelets and in the remainder of
61 ic mediators in asthmatic patients; however, inhibition of CysLT receptor 1 is not a consistently eff
62 Dysregulation of hydrogen sulfide (H(2)S) by inhibition of cystathionine gamma-lyase (CSE) increases
65 mmetry recordings confirmed that presynaptic inhibition of dopamine release by the KOR agonist U69,59
66 ns of agonist were required for half-maximum inhibition of dopamine-induced cAMP accumulation in cell
71 y human behavior requires the suppression or inhibition of errant or maladaptive motor responses, oft
72 ular vesicles in the vascular lumen and that inhibition of extracellular vesicle release blocks LTB4-
74 enetic ablation or selective pharmacological inhibition of FAAH bidirectionally dysregulates intracel
75 cy (SAI) but not long-latency (LAI) afferent inhibition of face M1, while facial nerve stimulation ev
76 regulates ITGA5/FN1 expression, resulting in inhibition of FAK/Src signaling, induction of apoptosis
79 hia in the bacterial biofilm can cause local inhibition of fibrinolysis, which could have possible de
82 ard has long been believed to be mediated by inhibition of GABA interneurons in the VTA that subseque
85 aining the intercalated cells, we found that inhibition of glutamate release by a submaximal concentr
87 aptation in glutamine metabolism and how the inhibition of glutaminase 1 (GLS1) reverses pulmonary fi
93 pin depletion and VX-680 was mediated by the inhibition of Haspin with Aurora kinase B (AURKB), but n
94 n solution demonstrated an isoform-dependent inhibition of hemolysis and complement deposition at the
96 ongly in females than males, perhaps because inhibition of hepatic mTORC2 (mTOR Complex 2) specifical
100 equences of such binding are suggested to be inhibition of HS cleavage in MDA-MB-231 triple-negative
101 A with short incubation time whereas maximum inhibition of HSA and PPA by EC was reached only after 4
105 roliferation in vitro, whereas pharmacologic inhibition of hyaluronidase activity prevented hypoxia-
106 ed the effects of genetic or pharmacological inhibition of IFN-beta, a key component of type I IFN me
109 tro capillary sprouting assays revealed that inhibition of IL-6 or STAT3 signaling decreases the vasc
110 L2RA expression as well as antibody-mediated inhibition of IL2RA in human cell lines, mouse models, a
115 In the pristane-induced lupus mouse model, inhibition of IRAK4 reduced the expression of IRGs durin
116 hat heme protects S. aureus from CP-mediated inhibition of iron uptake and iron-starvation responses.
123 cross-processing seems a promising tool for inhibition of lipid oxidation during pH-shift processing
124 vitro, including: antitumor effects through inhibition of lipogenesis; decreased expression of invas
128 fects, as antisense oligonucleotide-mediated inhibition of Malat1 also suppresses Maf and IL-10 level
135 oplasmic reticulum, which contributes toward inhibition of MHC class I:beta2M:peptide complex formati
140 nk1-deficient bone marrow or pharmacological inhibition of mitophagy promoted macrophage activation,
142 Additionally, pharmacological and genetic inhibition of MNK-eIF4E signaling completely blocked and
156 at lidocaine enhances the degree and rate of inhibition of Nav1.7 channels by the aryl sulfonamide co
157 ted it through overexpression, knockout, and inhibition of NCAM1 in Vero cells and human glioblastoma
159 sistent with this mechanism, pharmacological inhibition of NER using spironolactone abolished SIRT2-m
160 sition of NETs along the arterial lumen, and inhibition of NET release annulled lesion expansion duri
164 minobutyric acid (GABA) results in prolonged inhibition of neurotransmission, which is central to bra
165 ent tumor suppression, and more importantly, inhibition of neutrophil-mediated lung metastasis via th
171 lpha-cobratoxin (alpha-Cbtx) and prevent its inhibition of nicotinic acetylcholine receptors (nAChRs)
180 macodynamic studies demonstrated substantial inhibition of phosphorylation of CHK1, the downstream AT
182 nd xenografts of HCC tumors, suggesting that inhibition of PJA1 may be beneficial in treating HCC or
183 s potential pathological properties, such as inhibition of plasmin generation, have been attributed t
185 Abeta-induced impairments, and suggest that inhibition of PME-1 may constitute a viable therapeutic
186 modeling induced by pressure overload, while inhibition of PP2A signaling prevents eccentric cardiac
187 E efflux was not affected by pharmacological inhibition of PPARgamma activity, and specific activatio
189 t local nutrient depletion and the resulting inhibition of proliferation and motility of bacteria and
192 oli that cyclically interact through (i) the inhibition of protein production, (ii) the digestion of
193 iety of applications, including the covalent inhibition of protein targets and dynamic combinatorial
195 nd pppGpp interact with proteins involved in inhibition of purine nucleotide biosynthesis and with GT
196 ithin the BC network to generate synchronous inhibition of Purkinje cells, which can entrain cerebell
199 tion of wound repair is mediated through the inhibition of Rac family small GTPase 1 and cell divisio
202 xide decreases spermathecal contractility by inhibition of RHO-1, which depends on a conserved cystei
206 ion and tight junction breakdown, and led to inhibition of RPE65 expression, diminishment of RPE pigm
209 signaling, IL-6 signaling, LPS/IL-1-mediated inhibition of RXR Function, PI3K in B lymphocytes, iCOS-
210 ong evidence to show that template-dependent inhibition of SARS-CoV-2 RdRp by RDV is biologically rel
213 , little is known about how the ABA-mediated inhibition of seed germination and seedling establishmen
215 the structure of the headpiece underlie PLB inhibition of SERCA, and binding of a single Ca(2+) ion
216 OP toxicity is thought to involve off-target inhibition of serine proteases, although the precise mol
217 Finally, VZHE-039 showed no significant inhibition of several CYPs, demonstrated efficient RBC p
220 erfering RNA and Vivo-Morpholino, as well as inhibition of Smyd2 by its specific inhibitor, AZ505, le
221 nstatement of drug-seeking behavior, whereas inhibition of SNr GABA neurons produced optical intracra
223 inhibitor, compound 15a exhibited sustained inhibition of SRC signaling both in vitro and in vivo.
224 rgeting of uncontrolled self-renewal through inhibition of stem cell-related signaling pathways has p
226 l blockers, with possible application to the inhibition of subthreshold membrane depolarizations.
229 roid enhancer and TAL1 promoter-1 leading to inhibition of TAL1 expression in erythroid cells, but no
231 08348 engages alphavbeta6, induces prolonged inhibition of TGFbeta signaling and reduces lung collage
232 lexible N-terminal region and the associated inhibition of the activity is a novel mechanism of regul
242 deficits could be rescued by pharmacological inhibition of the eIF4G1 function and chemogenetic inhib
245 carbapenem efficacy in CRE E. coli, whereas inhibition of the genes flhC and ygaC conferred added re
248 ving the survival of PV(+) neurons, and that inhibition of the impairment of NR2B/PSD-95/MAP1A pathwa
249 ion of cystine to cysteine precludes product inhibition of the importer, so cystine import continues
252 note, we identified that in addition to the inhibition of the intracellular replication of HIV by au
253 ncy recorded from neurons in this region via inhibition of the inwardly rectifying K(+) channels.
254 gested that treatment decreased left frontal inhibition of the left amygdala, and larger decreases we
257 fting task while genetic and pharmacological inhibition of the MNK-eIF4E signaling axis protected aga
258 of the oncometabolite 2-hydroxyglutarate via inhibition of the mutant isocitrate dehydrogenase 1 (IDH
259 effect was attributable to the chemogenetic inhibition of the NAcC-projecting BLA neurons, as it was
261 of prodynorphin in the BNST and chemogenetic inhibition of the PFC-BNST pathway restored abnormal res
262 Withdrawal of GABA(A) receptor-mediated inhibition of the RVLM increases sympathetic outflow and
265 o- and Ala-stimulated R(N) were mitigated by inhibition of the Target of Rapamycin (TOR) kinase signa
267 c response is orchestrated by the reversible inhibition of the TMK1 signaling pathway at the cell sur
268 en projection neurons, feedback, and lateral inhibition of these axons by a large population of neuro
271 nly provides insights into the mechanism and inhibition of this transglutaminase-induced ubiquitinati
275 underlying this process was found to be the inhibition of TPPP1 by EBV-miRNA-BART12, which, in turn,
277 f treatment effect modification resulting in inhibition of treatment effect in patients receiving alt
278 ing a prometastatic transcriptional program; inhibition of TRIM37 increases chemotherapy efficacy and
279 haracteristic of a metastatic phenotype, and inhibition of TRIM37 substantially reduced the in vivo p
284 ombined with focal irradiation causes strong inhibition of tumor growth in mouse xenografts, compared
285 on of (212)Pb-L2 demonstrated dose-dependent inhibition of tumor growth in the PSMA(+) flank tumor mo
286 L1 demonstrated activity-dependent, specific inhibition of tumor growth in the PSMA+ flank tumor mode
287 erate breast cancer metastasis, and targeted inhibition of tumor-derived vesicles may be a promising
291 gene on one allele, with subsequent feedback inhibition of V(D)J recombination on the other allele.
295 The gain in affinity led to almost equal inhibition of wildtype PfFNT and the Gly107Ser mutation.
296 d the set of genes that are upregulated upon inhibition of Wnt signaling in Wnt-addicted pancreatic a
298 26a was able to induce an 80% tumor growth inhibition of xenografts derived from the enzalutamide-r