ライフサイエンスコーパス: initial response

1 t baseline) or acquired (ie, developed after initial response).

2 /-63%, respectively (each P<0.001 versus the initial response).

3 a stable response after 4 weeks (96% of the initial response).

4 or near-normal swallowing (excellent or good initial responses).

5 late residual multiple myeloma (MM) after an initial response.

6 d viral breakthrough within 15 days after an initial response.

7 actory to this treatment or relapse after an initial response.

8 re resistance to HER2-targeted therapy after initial response.

9 tinib but some fail to respond or lose their initial response.

10 apy cycles was determined by rapidity of the initial response.

11 ese early time points, reflecting a rigorous initial response.

12 e develops rapidly in most patients after an initial response.

13 teristics of depression predicted time until initial response.

14 ited to patients with a true drug pattern of initial response.

15 of afferents from those activated during the initial response.

16 in (0.5 mg kg-1), which had no effect on the initial response.

17 with IL-4 involved in downregulation of the initial response.

18 ond to chemotherapy and 25-50% relapse after initial response.

19 predict patient survival solely based on the initial response.

20 ic) examined the details and outcomes of the initial response.

21 day or 400 mg twice per day if there was no initial response.

22 itable recurrence of resistant disease after initial responses.

23 ed drug resistance frequently develops after initial responses.

24 ites, is required for the rapid dampening of initial responses.

25 at three levels long-term response (OS), the initial response (according to RECIST criteria), and the

26 Despite a promising initial response, acquired resistance emerges rapidly to

27 In spite of this initial response, Ag presentation by ProAd-ICAM is a tol

28 therapy may be beneficial in cases with poor initial response and cyclitic membrane formation.

29 ough medical or surgical castration leads to initial response and durable remission, but resistance i

30 Loss of initial response and infusion reactions post-infliximab

31 ateau level that was typically 10-40% of the initial response and persisted at this level for at leas

32 racterizing the ratio of time scales for the initial response and recovery time of the system which c

33 course of an outbreak can change the optimal initial response and result in significant cost savings.

34 re youths sought help, and the timeliness of initial response and services improved over time.

35 ATM is critical for the initial response and the subsequent ATR activation.

36 ly differentiates true drug from nonspecific initial responses and extend its use to the continuation

37 After the initial response, antiandrogens lose their efficacy and

38 During quiet wakefulness, an initial response (approximately 15 milliseconds) at the

39 Factors that trigger this initial response are not well understood.

40 However, such initial responses are almost always followed by relapse,

41 sms involved in producing habituation of the initial responses are located more centrally than the pe

42 Furthermore, initial response assessment by conventional imaging is o

43 Initial response assessments 12 wk after radioimmunother

44 spherules in order to better understand the initial response between Coccidioides and the human host

45 assess outcomes in patients who have a poor initial response but continue treatment without switchin

46 assess outcomes in patients who have a poor initial response but continue treatment without switchin

47 ive cytotoxic chemotherapy results in a good initial response but limited long-term survival.

48 and conjunctiva may be associated with good initial response, but the risk of distant relapse is abo

49 ilarly treated TNF-/- mice show little or no initial response, but then develop a vigorous, disorgani

50 ing at lower frequencies (<20 Hz) during the initial response, but was limited (<20% of the explained

51 preincubated for 10 s, it decreased the peak initial response by approximately 15%.

52 While initial response can be favorable, the disease typically

53 However, despite these remarkable initial responses, cancers eventually develop resistance

54 amental alone were also abnormal, in that an initial response component normally present in the ERG w

55 contrast, bipolar cell synapses with strong initial responses depressed, whereas synapses with weak

56 front-line therapies or who relapse after an initial response die from progressive disease.

57 y, thus suggesting cortical amplification of initial responses driven by thalamocortical inputs.

58 e dark, which could be essential for a rapid initial response during dark-to-light transition.

59 Based on the patient's initial response, early BRPV identification and antivira

60 ial phase of the response (the phenomenon of initial response enhancement).

61 dvanced cancers, including those with robust initial responses, eventually acquire resistance to targ

62 ponses depressed, whereas synapses with weak initial responses facilitated.

63 Patients with initial response followed by acquired resistance to ther

64 re decreased in two phases: an instantaneous initial response, followed by a slower change in length

65 Dark pretreatment did not change the lag to initial response following hormone application to vertic

66 on is essential for boosting and shaping the initial response following signaling through the antigen

67 (IL4) to the IL4 receptor (IL4R) induces the initial response for Th2 lymphocyte polarization.

68 tial response to treatment and those with an initial response for whom treatment later failed) or fro

69 confidence" (>=8 on the 1-10 scale) for most initial responses (GPT-3.5, 100% [150 of 150]; and GPT-4

70 stages of sensory processing: arousal (i.e., initial response), habituation (i.e., change in response

71 entify mechanisms of treatment failure after initial response has become of immediate therapeutic rel

72 a medulloblastoma patient who had a dramatic initial response has spurred efforts to understand poten

73 rapy therapy or who experience relapse after initial response have dismal outcomes.

74 However, initial responses have not been sustained, with a median

75 Despite initial response, his disease progressed after 4 months,

76 Regardless of the specificity of initial responses, IE1-specific responses predominated b

77 ytic methods to separate the strength of the initial response impulse from the proficiency of inhibit

78 e fluctuated, with some deterioration of the initial response in 49.6% of patients (median time of de

79 Rituximab produces an initial response in approximately 60% of cases, with no

80 After an initial response in most patients, tumors invariably pro

81 anced both the magnitude and duration of the initial response in preclinical models of EML4-ALK lung

82 We observed an initial response in the hemisphere contralateral to the

83 These receptors mediate initial responses in innate immunity and are required fo

84 The molecular events mediating the initial responses in mDC remain unclear.

85 nts who underwent stem cell transplantation, initial responses in most patients were good to excellen

86 Flutamide altered initial response, increasing latency to enter the pup ca

87 ation, sequential herbivory counteracted the initial responses induced by O3, resulting in a phenotyp

88 t was predominantly in patients for whom the initial response interval was 4 minutes or longer (survi

89 are stable, resistance to treatment after an initial response is common in more advanced phases of th

90 The mechanism for this initial response is unclear.

91 improved response with longer therapy beyond initial response, leading to continued improvement in ov

92 i.e. critical temperature (T(crit) ) and the initial response (m(1) ), were evaluated for their usabi

93 Eyes with poor initial response may benefit from continued treatment wi

94 binding suggest a role for the protein as an initial response mechanism for chitin perception in soyb

95 ve malignancy with poor survival rates, with initial responses nearly invariably followed by rapid re

96 Typically, the initial response of a prostate cancer patient to androge

97 pacia are associated with differences in the initial response of alveolar macrophages (AM) to these p

98 res, we have identified genes central to the initial response of Arabidopsis to hypobaria.

99 ntraindication for donation, as has been the initial response of donation and transplant societies.

100 results give a comprehensive picture of the initial response of E. coli to hyperosmotic shock and of

101 We examined the initial response of freshly isolated human leukocytes to

102 The initial response of heart rate to dynamic exercise has b

103 i) increased membrane fluidity following the initial response of increased rigidity, and (iv) no chan

104 The initial response of liver cells to insulin is mediated t

105 vo biotinylation in zebrafish to analyse the initial response of neutrophils to Mycobacterium marinum

106 Mg2+ affects the initial response of PC12 cells to 2MeSATP in a manner si

107 Importantly, collagen I induced a similar initial response of protrusions and dissemination in bot

108 cs due to hydrophobic mismatch, in which the initial response of the apposed leaflets upon quenching

109 We sought to understand the initial response of the BBB to the human meningeal patho

110 cadian clock, and Tim degradation may be the initial response of the clock to light.

111 Interestingly, the initial response of the cyclic AMP response element prom

112 ay be of pathophysiological relevance in the initial response of the organism to infection.

113 We concluded that the robust initial response of the p53 pathway to GART inhibitors i

114 e that the snky+ product is required for the initial response of the sperm to cytoplasmic cues in the

115 ell enables time-resolved measurement of the initial response of VVD to illumination.

116 It should be noted that the initial responses of IL-6 and IL-8 up to T = 4 hours wer

117 lasting hyperpolarization and suppresses the initial responses of input from layer 4 and that this in

118 However, the initial responses of the ONH to elevated IOP are unknown

119 e subtype appeared to be associated with the initial response or relapse.

120 engthening were national preparedness plans, initial response, plans for securing vaccine supply, and

121 total, 152 patients (61%) showed an overall initial response (platelet count >/=30 x 10(9)/L and >/=

122 ins are deleterious, cells downregulate this initial response rapidly.

123 selective BRAF inhibitors results in a high initial response rate but limited duration of response.

124 inase kinase (MEK) inhibitors induces a high initial response rate in patients with BRAF(V600)-mutate

125 The overall initial response rate of 94% included 74% complete remis

126 ng cancer (LSCLC) is characterized by a high initial response rate to chemoradiotherapy, but local or

127 The initial response rate to fludarabine was 82% (94 of 115

128 Despite initial response rates of greater than 90%, 15%-30% of p

129 Despite the high initial response rates to PARP inhibitors (PARPi) in BRC

130 d malignancies, and despite their impressive initial response rates, a significant proportion of pati

131 patient in the neostigmine group without an initial response received open-label neostigmine; all ha

132 that observed on response trials (where the initial response remains appropriate and no control is i

133 n 18 of 22 baseline scans (82%) and 15 of 17 initial response scans (88%).

134 that these early changes reflect changes in initial response selection, possibly by alterations in t

135 However, despite their initial response, such cancers almost invariably develop

136 After the initial response, tension and volume recovered from hypo

137 AstraZeneca-primed participants have lower initial responses than CoronaVac-primed participants fol

138 C neurons gave an identical initial response that remained steady, declining only 6%

139 nd a specific binding response on top of the initial response, the magnitude of which is dependent on

140 At 12 months after the initial response, the rate of relapse-free survival was

141 Despite initial responses, the development of resistance limits

142 After encouraging initial responses, the study was expanded to further eva

143 he addition of Ca(2+) was associated with an initial response time (IRT) of mV(O(2)) that was dose-de

144 experiment occurred in trials with prolonged initial response times.

145 n single units from these bundles during the initial response to 10 micrograms 5-HT was 13.0 +/- 1.8

146 The initial response to 5-HT was unaffected by the L-type ca

147 The initial response to activated Notch1 was proliferation a

148 ber of LHPA alterations, including a blunted initial response to acute restraint stress followed by a

149 investigated whether characterization of the initial response to adrenocortical steroids and the cour

150 Surprisingly, we determined that the initial response to Ag at day 3 (d3) in the mediastinal

151 We find that as an initial response to altered culture conditions, hESCs ch

152 0% mortality by week 10, and (iii) while the initial response to AmB and miltefosine was intact, kill

153 The initial response to an addictive substance can facilitat

154 The initial response to an ischemic event is the rapid relea

155 etastatic prostate cancer who achieve a good initial response to androgen deprivation.

156 lioblastomas (rGBM) invariably relapse after initial response to anti-VEGF therapy.

157 ing CD8(+) T cells is to set the size of the initial response to antigen by promoting T cell prolifer

158 severity is more closely associated with the initial response to antirejection therapy and long-term

159 y a significant risk for graft loss, and the initial response to antirejection therapy can predict lo

160 IRs, and 6:1 in NRs; P < .001) and in their initial response to any therapy, including proton pump i

161 The initial response to ASHAP before subsequent ABMT consoli

162 ffect basal VP release and did not alter the initial response to ATP.

163 red superficial dermal nerve bundles was the initial response to axotomy.

164 reduction in TGF-beta activity augments the initial response to BCG vaccination, early bacterial cle

165 An initial response to BCT was not found to be predictive f

166 movement were negatively correlated and the initial response to BT treatment positively correlated w

167 3), we examined the relationship between the initial response to changes in PEEP after randomization

168 d regrowth than control xenografts following initial response to chemotherapy suggesting that a high

169 After an initial response to chemotherapy, many patients with tri

170 ts propensity to develop resistance after an initial response to chemotherapy.

171 This study supports the notion that initial response to clozapine occurs within the first fe

172 first-defense pathway of myeloid cells as an initial response to CNS invasion and demonstrates that T

173 ned these results with respect to each rat's initial response to cocaine, response to a novel environ

174 men could sustain viral suppression after an initial response to combination therapy.

175 both point to the key role of nucleus in the initial response to copper overload and suggest time-dep

176 response modifiers in early disease or after initial response to cytotoxic chemotherapy.

177 We defined a poor initial response to darbepoetin alfa (which occurred in

178 Patients who had a poor initial response to darbepoetin alfa had a lower average

179 reduced symptoms in 67% of patients with an initial response to donor stool but not in patients with

180 larly in cases of toxoplasmosis in which the initial response to drug treatment is poor.

181 mechanism by which resistance arises and the initial response to drug treatment that promotes cell su

182 Although mUC patients show initial response to erdafitinib, acquired resistance rap

183 itates significant Fe(III) uptake during the initial response to Fe limitation.

184 Despite an excellent initial response to first-line hormonal treatment, most

185 ge proportion of solid tumor cell lines, the initial response to flavopiridol is cell cycle arrest.

186 t subjects with an ff genotype had the least initial response to fructan.

187 loblastoma patient who had relapsed after an initial response to GDC-0449, we determined the mutation

188 However, despite their initial response to genetic EGFR* extinction, all tumors

189 ly myelopathic symptoms and had a favourable initial response to high dose glucocorticosteroids.

190 This initial response to hyperosmolarity precedes and tempora

191 The initial response to IFNalpha is characterized by chromat

192 in which the CML cell line KCL-22, following initial response to imatinib, develops resistant T315I B

193 All treated patients (4) demonstrated an initial response to immunotherapy (corticosteroids [4],

194 Initial response to induction chemotherapy predicts fail

195 asured by BH3 profiling was a determinant of initial response to induction chemotherapy, relapse afte

196 has shown that in this past era, absence of initial response to induction therapy had no impact on p

197 Despite initial response to induction therapy, nearly 50% of hig

198 infliximab (primary nonresponse), 38 had an initial response to infliximab but relapsed (secondary n

199 f an individual may profoundly influence the initial response to inhaled Ag, and that aerosol-induced

200 In many cases, the initial response to inhibition of replication was a pers

201 We conclude that the initial response to interferon in patients with chronic

202 n Group 2, oral steroids were added after an initial response to intravenous antibiotics.

203 de direction of immune cell differentiation, initial response to invading pathogens and ischemic inju

204 hether Ag presentation is decreased after an initial response to Leishmania major.

205 The initial response to ligand stimulation was increased and

206 ptides, and resident effector cells form the initial response to mechanical injury of the skin.

207 ation of the anterior-posterior axis and the initial response to mesoderm-inducing signals is intact

208 s, although unburned grassland showed little initial response to multiple ecological presses, our res

209 Two patients who had an initial response to neostigmine required colonoscopic de

210 Therefore, strategies to improve on the initial response to nucleoside analog therapy are likely

211 Although the initial response to partial hepatectomy at the priming p

212 TRM orchestrate the initial response to pathogens re-encountered at these lo

213 onse to therapy in patients with an adequate initial response to peginterferon.

214 ed superoxide production as well as a weaker initial response to phorbol ester.

215 Initial response to photoexcitation is assigned to local

216 than heat shock proteins, which changes the initial response to poliovirus infections from persisten

217 Among smokers who did not show a sufficient initial response to prequit nicotine patch treatment, co

218 edictors for favorable outcome are having an initial response to PRRT, having a low number of affecte

219 arboring BRAF V600E was a biomarker of worse initial response to RAF and MEK inhibition in patients,

220 vaccines now in development at impacting the initial response to re-exposure to M. tuberculosis in th

221 Chronic graft-versus-host disease and an initial response to SCT predicted longer OS.

222 e to individual differences in the timing of initial response to sound onset.

223 While the amplitude of the initial response to stimulation at attended peripheral l

224 r/lpr mice occurs in two phases: an abortive initial response to T help followed by full loss of tole

225 for breast cancer commonly develops after an initial response to tamoxifen or aromatase inhibitors.

226 This reflects in part the fact that the initial response to TH induction in both tissues is cell

227 re particularly responsible for mounting the initial response to the cGVH stimulus.

228 not respond or eventually relapse after the initial response to the current treatments.

229 The initial response to the gene deletions was flux reroutin

230 U.S. Navy internists who participated in the initial response to the Haitian earthquake disaster onbo

231 higher dose in patients progressing after an initial response to the standard dose therapy.

232 n the acute phase, or how disparities in the initial response to the virus may affect disease.

233 nous imageable murine model of melanoma from initial response to therapeutic resistance, offering new

234 However, some patients lack an initial response to therapy (i.e., are refractory), and

235 gender, extent of cutaneous involvement, and initial response to therapy had no statistically signifi

236 Initial response to therapy was excellent, with 99% clea

237 In the analysis of this subgroup, initial response to therapy was similar for both drugs (

238 as at diagnosis perhaps accounting for their initial response to therapy, but advanced neuroblastoma

239 Despite an initial response to therapy, drug resistance remains a p

240 at the implant in individual mice showed an initial response to therapy, which over time differentia

241 ich contribute to tumor recurrence following initial response to therapy.

242 Although the initial response to these inhibitors can be dramatic, so

243 Forty percent of patients have an initial response to this therapy, but most subsequently

244 onding patients (defined as patients with no initial response to treatment and those with an initial

245 who delivered the interventions and reported initial response to treatment was not possible.

246 Clinical evidence shows that following initial response to treatment, drug-resistant cancer cel

247 After the initial response to treatment, the majority of tumors wi

248 Despite the high rate of initial response to treatment, these low-grade B-cell no

249 measures were response to treatment, time to initial response to treatment, time to complete resoluti

250 -small cell lung cancer (NSCLC) despite high initial response to tyrosine kinase inhibitor (TKI) trea

251 Patients with an initial response to ustekinumab had significantly increa

252 P (TC-PTP) activity is stimulated during the initial response to UVB irradiation, which leads to supp

253 ate of a metastatic lesion progressing after initial response to vaccination.

254 t CD49b T(EM) expansion is restricted to the initial response to vaccine.

255 The initial response to viral infection is anticipatory, wit

256 The initial response to viral infection is characterized by

257 The initial response to WNV resulted in the expression of in

258 he protective role of basal autophagy in the initial responses to a subset of neurodegenerative chall

259 However, while initial responses to B-raf inhibitors are impressive, re

260 stinent cigarette smokers, nicotine augments initial responses to both gradual and rapid non-painful

261 Patients with EVI-1-positive AML have poor initial responses to chemotherapy and high relapse rates

262 Initial responses to conspecific song and calls and to h

263 Although initial responses to FLT3 tyrosine kinase inhibitors (TK

264 ment of schizophrenic patients who show poor initial responses to haloperidol.

265 ying the signaling pathways that mediate the initial responses to interferons (IFNs), much less is kn

266 l biopsies from kidney transplants, that the initial responses to kidney injury correlate with a late

267 stress hyporesponsiveness suggest that these initial responses to MDMA may contribute to the long-ter

268 Initial responses to P limitation showed increased expre

269 Initial responses to P6 were CR/VGPR in 19 patients, but

270 daily for up to 5 doses; 3 patients who had initial responses to SL-401 received a second course in

271 nction of glucagon-like peptide-1 (GLP-1) in initial responses to taste stimulation.

272 ignificantly shorter than the latency of the initial responses to the search display, with approximat

273 ALK-expressing (ALK(+)) tumours show strong initial responses to the series of ALK inhibitors curren

274 Initial responses to tilt were comparable; however, duri

275 Despite comparable initial responses to Trp2 immunization, WT Trp2/K(b)-spe

276 sure changes below resting levels but normal initial responses to upright tilt.

277 lation state of receptors is likely to be an initial response upon ethylene binding since treatments

278 Patients who had a poor initial response (VA 20/40 or worse with persistent flui

279 is model is a mechanistic description of how initial response variability is generated.

280 Initial response was determined with findings of decreas

281 The cohort included 2 subjects whose initial response was followed by drug-sensitive relapse.

282 This initial response was mimicked by the 5-HT3 receptor agon

283 (ala) was expressed in sensory neurons, the initial response was reduced, followed by facilitation.

284 3), The initial response was reversibly reduced by 5-mM 2,3-buta

285 The initial response was similar in high flow and low flow M

286 During non-rapid eye movement sleep, the initial response was stronger but was rapidly extinguish

287 ate binding and to investigate the protein's initial response, we performed equilibrium simulations o

288 Eleven of 15 patients (73%) who lost their initial response were ATI positive compared with none of

289 However, initial responses were followed by subsequent tumor re-g

290 Although initial responses were lower, accelerated adequate immun

291 By 36 months after infection, 14 of 15 initial responses were still detectable in both, whereas

292 pidly dissociates from the genome during the initial response when the cytoplasmic K(+) accumulates t

293 where CD8(+) T cells are limiting during the initial response whereas antigen is limiting in the seco

294 d imaging techniques, we determined that the initial response, which occurs within the first second o

295 ogic response or viral rebound subsequent to initial response while on treatment with lopinavir-riton

296 bsequently increased to levels exceeding the initial response, while mean EMG responses increased thr

297 nse to ICI, unfortunately many patients with initial response will later develop acquired resistance.

298 rate-invariant speed of depression allows an initial response window that still contains presynaptic

299 Comparing to the initial response within 12 hours, gene expression modula

300 Price reductions or payment for initial response would improve cost effectiveness, even