ライフサイエンスコーパス: initiation factor

1 slation through eIF4B, a general translation initiation factor.

2 t is catalysed by this universally conserved initiation factor.

3 autophagy-related processes, and translation initiation factors.

4 was not observed before in other translation initiation factors.

5 d may represent a new group of transcription initiation factors.

6 p and some/all of the associated translation initiation factors.

7 get mRNAs and interacting with translational initiation factors.

8 cation origins compete for a limited pool of initiation factors.

9 , like the CrPV IRES, eliminate the need for initiation factors.

10 ble to initiate translation without any host initiation factors.

11 V mutant could not interact with translation initiation factors.

12 ganization, and the abundance of translation initiation factors.

13 teracts genetically with Pol I transcription initiation factors.

14 ultiple steps and the engagement of numerous initiation factors.

15 As, using different sets of host translation initiation factors.

16 EIF1AY, which encodes eukaryotic translation initiation factor 1A Y-linked, together with its X-linke

17 cell; therefore, the eukaryotic translation initiation factor 2 (eIF2) gene family is a likely candi

18 Eukaryotic initiation factor 2 (eIF2) is a G protein critical for t

19 Eukaryotic translation initiation factor 2 (eIF2) is a heterotrimeric GTPase, w

20 Eukaryotic initiation factor 2 (eIF2) is a key integrator of cellul

21 nsing amino acid depletion by the eukaryotic initiation factor 2 (eIF2) kinase GCN2.

22 In eukaryotes, initiation factor 2 (eIF2) plays an important role in tr

23 se R (PKR), which inactivates the eukaryotic initiation factor 2 (eIF2) translation initiation factor

24 orylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2).

25 d stress kinases to phosphorylate eukaryotic initiation factor 2 (eIF2).

26 iver, including alpha subunit of translation initiation factor 2 (eIF2alpha) phosphorylation, activat

27 es phosphorylation of eukaryotic translation initiation factor 2 (eIF2alpha) resulting in inhibition

28 Dephosphorylation of translation initiation factor 2 (eIF2alpha) terminates signalling in

29 the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) was decreased, and host

30 orylation of the alpha subunit of eukaryotic initiation factor 2 (eIF2alpha).

31 nitiation factor alpha subunit of eukaryotic initiation factor 2 (eIF2alpha).

32 llosteric activation of the essential GTPase Initiation Factor 2 (IF2) during translation initiation.

33 g at serine-51 phosphorylation on eukaryotic initiation factor 2 alpha (eIF2alpha) and activate the i

34 llular stress by deactivating the eukaryotic initiation factor 2 alpha (eIF2alpha) or other signal tr

35 ith and can methylate eukaryotic translation initiation factor 2 alpha (eIF2alpha), in vitro and in b

36 ) that phosphorylates eukaryotic translation initiation factor 2 alpha (eIF2alpha), which orchestrate

37 he phosphorylation of eukaryotic translation initiation factor 2 alpha (eIF2alpha).

38 KR) and its substrate eukaryotic translation initiation factor 2 alpha (eIF2alpha).

39 encode members of the eukaryotic translation initiation factor 2 alpha kinase (EIF2AK) family that in

40 , p.Gly130Arg, in the eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2) gene, segre

41 (phosphorylation) of eukaryotic translation initiation factor 2 alpha kinase 3 (EIF2AK3, also called

42 elic mutations in the eukaryotic translation initiation factor 2 alpha kinase 4 gene (EIF2AK4) are de

43 tein loss led to the induction of eukaryotic initiation factor 2 alpha subunit (eIF2alpha) signaling

44 s the ages, corroborating similar eukaryotic initiation factor 2 phosphorylation responses to asparag

45 dent of source of infection, with eukaryotic initiation factor 2 signaling being the most enriched ca

46 R, phosphorylation of eukaryotic translation initiation factor 2 subunit 1 (eIF2alpha), the SG assemb

47 EIF2AKs phosphorylate eukaryotic translation initiation factor 2 subunit 1 (EIF2S1, also known as EIF

48 ylates its substrate, eukaryotic translation initiation factor 2 subunit alpha (eIF2alpha), causing i

49 hosphorylation of the eukaryotic translation initiation factor 2 subunit alpha (EIF2S1 or EIF2A), whi

50 actor eIF2alpha (alpha subunit of eukaryotic initiation factor 2), ensuring viral protein synthesis.

51 response (ISR) by phosphorylated translation initiation factor 2, eIF2(alphaP).

52 al control via phosphorylation of eukaryotic initiation factor 2, which is implicated in learning and

53 ation mediated by the eukaryotic translation initiation factor 2-alpha kinase 2/eukaryotic translatio

54 hat activation of the eukaryotic translation initiation factor 2-alpha kinase 2/eukaryotic translatio

55 se RNA-like ER kinase/eukaryotic translation initiation factor 2-alpha/activating transcription facto

56 in kinases that phosphorylate the eukaryotic initiation factor-2 (eIF2) function in translational con

57 ctor 2-alpha kinase 2/eukaryotic translation initiation factor 2alpha (EIF2AK2/eIF2alpha) axis as a m

58 ctor 2-alpha kinase 2/eukaryotic translation initiation factor 2alpha (Eif2ak2/Eif2alpha) axis is the

59 ed phosphorylation of eukaryotic translation initiation factor 2alpha (eIF2alpha) and regulated expre

60 Phosphorylation of translation initiation factor 2alpha (eIF2alpha) attenuates global p

61 Phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha) controls transcript

62 in the heme-regulated eukaryotic translation initiation factor 2alpha (eIF2alpha) kinase (HRI).

63 The eukaryotic translation initiation factor 2alpha (eIF2alpha) kinase GCN2 is acti

64 ) or phosphodeficient eukaryotic translation initiation factor 2alpha (eIF2alpha) mouse embryonic fib

65 e-inducible protein 34) prolonged eukaryotic initiation factor 2alpha (eIF2alpha) phosphorylation, le

66 The eukaryotic translation initiation factor 2alpha (eIF2alpha) phosphorylation-dep

67 he phosphorylation of eukaryotic translation initiation factor 2alpha (eIF2alpha) results in the indu

68 ulum kinase (PERK) phosphorylates eukaryotic initiation factor 2alpha (eIF2alpha) to attenuate global

69 PP1alpha) to dephosphorylate the translation initiation factor 2alpha (eIF2alpha) to prevent host tra

70 ation through a process requiring eukaryotic initiation factor 2alpha (eIF2alpha), the transcription

71 nvolve chronic phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha), with deletions of

72 4E (eIF4E) and phosphorylation of eukaryotic initiation factor 2alpha (p-eIF2alpha).

73 hosphorylation of the eukaryotic translation initiation factor 2alpha and enhanced translation of bet

74 Abeta-induced inactivation of the eukaryotic initiation factor 2alpha decreases the synaptic abundanc

75 Abeta-induced inactivation of the eukaryotic initiation factor 2alpha halts the transcription of uPA

76 cally reducing phosphorylation of eukaryotic initiation factor 2alpha in excitatory neurons in the LA

77 trol nonderepressible 2-dependent eukaryotic initiation factor 2alpha phosphorylation and activating

78 d within a few days, resulting in eukaryotic initiation factor 2alpha phosphorylation, TCRzeta-chain

79 pancreatic ER kinase/eukaryotic translation initiation factor 2alpha signaling.

80 hosphorylation of the eukaryotic translation initiation factor 2alpha subunit and the splicing of Xbp

81 inase R, which phosphorylates the eukaryotic initiation factor 2alpha to inhibit global protein trans

82 in and phosphorylated eukaryotic translation initiation factor 2alpha unchanged.

83 and reversible phosphorylation of eukaryotic initiation factor 2alpha, leading to inhibition of gener

84 l of nuclear ATF6, phosphorylated eukaryotic initiation factor 2alpha, nuclear XBP1, and the downstre

85 n phosphorylation of the parasite eukaryotic initiation factor-2alpha (eIF2alpha), leading to repress

86 pha and the subsequent control of eukaryotic initiation factor 2B (eIF2B), a multisubunit guanine nuc

87 phosphorylated epsilon subunit of eukaryotic initiation factor 2B [eIF2Bepsilon(S536)] is hyperphosph

88 d by mutations in subunits of the eukaryotic initiation factor 2B complex (eIF2B).

89 ble polymerization of eukaryotic translation initiation factor 2B, an essential enzyme in the initiat

90 03), an allele of the eukaryotic translation initiation factor 2B-beta (eIF2Bbeta).

91 e, we show that human eukaryotic translation initiation factor 3 (eIF3) acts as a distinct repressor

92 core component of the eukaryotic translation initiation factor 3 (eIF3) complex, as a key downstream

93 Eukaryotic translation initiation factor 3 (eIF3) is a central player in recrui

94 ation requires the recruitment of eukaryotic initiation factor 3 (eIF3), but also requires cap recogn

95 irus (HCV) IRES binds eukaryotic translation initiation factor 3 (eIF3), but the exact functional rol

96 After 30S maturation, RbfA is displaced by initiation factor 3 (IF3), which promotes translation in

97 process that involved eukaryotic translation initiation factor 3 subunit b as a P311 binding partner.

98 TOR co-localised with Eukaryotic translation initiation factor 3 subunit F (eIF3F) at the cell membra

99 lieves the inhibitory function of eukaryotic initiation factor 3f, a repressive component in the 43S

100 al translation factor eukaryotic translation initiation factor 4 gamma I (eIF4GI) is cleaved by viral

101 s by interacting with eukaryotic translation initiation factor 4A (eIF4A) and inhibiting its helicase

102 in vivo by specifically targeting eukaryotic initiation factor 4A (eIF4A) and interfering with recrui

103 The eukaryotic initiation factor 4A (eIF4A) is a DEAD box helicase that

104 activity by clamping eukaryotic translation initiation factor 4A (eIF4A) onto polypurine sequences i

105 Eukaryotic initiation factor 4A (eIF4A), an ATP-dependent DEAD-box

106 a deletion mutant that binds to translation initiation factor 4A (eIF4A), sufficiently inhibited Sin

107 factors involved in 40S scanning (eukaryotic initiation factor 4A [eIF4A], eIF4B, and Ded1), indicati

108 urther, we found that eukaryotic translation initiation factor 4B (eIF4B) played a key role, as the m

109 The eukaryotic translation initiation factor 4E (EIF-4E) protein, a key regulator o

110 a (AML) by regulating eukaryotic translation initiation factor 4E (eIF4E) activation.

111 Dysregulation of translation initiation factor 4E (eIF4E) activity occurs in various

112 hat are sensitive to depletion of eukaryotic initiation factor 4E (eIF4E) and phosphorylation of euka

113 Eukaryotic translation initiation factor 4E (eIF4E) binds the m7GTP cap structu

114 EMSAs) indicated that eukaryotic translation initiation factor 4E (eIF4E) binds the MTE despite the a

115 slation by preventing eukaryotic translation initiation factor 4E (eIF4E) from binding to p53 mRNA.

116 Thus, AR suppressed eukaryotic initiation factor 4E (eIF4E) phosphorylation, while the

117 Eukaryotic translation initiation factor 4E (eIF4E) selectively promotes transl

118 e cap-binding protein eukaryotic translation initiation factor 4E (eIF4E) with eIF4G is a key control

119 Here, we focus on eukaryotic translation initiation factor 4E (eIF4E), a prooncogenic protein hig

120 is the complex between cap-bound eukaryotic initiation factor 4E (eIF4E), eIF4G, and poly(A) tail-bi

121 e, we discovered that eukaryotic translation initiation factor 4E (eIF4E), itself a cap-binding prote

122 g kinase 1 (MNK1) and eukaryotic translation initiation factor 4E (eIF4E), resulting in enhanced tran

123 were bound tightly to eukaryotic translation initiation factor 4E (eIF4E), with CCl2-substituted anal

124 Moreover, eukaryotic translation initiation factor 4E (EIF4E)-associated protein 1 (Eap1)

125 Eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1)

126 hosphorylation of the eukaryotic translation initiation factor 4E (eIF4E)-binding protein 1 (4E-BP1),

127 n of MTFP1, which is mediated by translation initiation factor 4E (eIF4E)-binding proteins (4E-BPs).

128 mRNAs is achieved through the cap-eukaryotic initiation factor 4E (eIF4E)-eIF4G-eIF3-40S chain of int

129 rtance of the p38-MNK-eukaryotic translation initiation factor 4E axis in TNF production downstream o

130 ting mTORC1 effectors eukaryotic translation initiation factor 4E binding protein 1 and Unc-51 like a

131 that binds to eIF4E (eukaryotic translation initiation factor 4E) and prevents mRNA decapping.

132 ing protein eIF4E (eukaryotic translation in initiation factor 4E) by 4E-BP1 (eIF4E-binding protein 1

133 its interactions with eukaryotic translation initiation factor 4E, and resists decapping.

134 mycin, phosphorylated eukaryotic translation initiation factor 4E, phosphorylated 4E-binding protein

135 ing kinase (MNK), and eukaryotic translation initiation factor 4E, which is a critical regulator of t

136 al protein S6 kinase 1 (S6K1) and eukaryotic initiation factor 4E-binding (eIF4E-binding) protein 1 (

137 reased recruitment of eukaryotic translation initiation factor 4E-binding protein (4E-BP) 1 in the tr

138 mycin (mTOR)-directed eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) phosphor

139 synthesis, including eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1), a negat

140 its downstream target eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1).

141 by phosphorylation of eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1).

142 tein S6 kinase 1, and eukaryotic translation initiation factor 4E-binding protein 1 during postexerci

143 mice with deletion of eukaryotic translation initiation factor 4E-binding protein 2 (4E-BP2), we dete

144 ion repressor, 4E-BP (eukaryotic translation initiation factor 4E-binding protein).

145 osphorylation and inactivation of eukaryotic initiation factor 4E-binding proteins (4E-BPs)(13).

146 ed by the translation inhibitors, Eukaryotic initiation factor 4E-binding proteins (4E-BPs).

147 A substitutes for the eukaryotic translation initiation factors 4E and 4G and activates mTOR-independ

148 t of rapamycin (mTOR)-eukaryotic translation initiation factor 4F (eIF4F) and eIF2alpha pathways, whe

149 rograms through the regulation of eukaryotic initiation factor 4F (eIF4F) and ternary complex.

150 It binds to the eukaryotic initiation factor 4F (eIF4F) complex and promotes 48S pr

151 mplex by the cap-binding complex [eukaryotic initiation factor 4F (eIF4F)] at the 5' end of messenger

152 for formation of the eukaryotic translation initiation factor 4F complex (eIF4F) and initiation of m

153 he O-GlcNAcylation of eukaryotic translation initiation factor 4gamma1 (eIF4G1) and carboxypeptidase

154 expression levels of eukaryotic translation initiation factor 4GI (eIF4GI) and of its homolog, death

155 isrupted the putative eukaryotic translation initiation factor 4GI-binding domain and promoted the sy

156 own downregulation of eukaryotic translation initiation factor 5 A (elF5A), expressed only in activel

157 cally, Klf5 activates eukaryotic translation initiation factor 5a (eIF5a) transcription through bindi

158 The eukaryotic initiation factor 5A (eIF5A), which is highly conserved

159 sttranslational activation of the eukaryotic initiation factor 5A.

160 hypusinated protein, eukaryotic translation initiation factor 5A.

161 gle cellular protein, eukaryotic translation initiation factor-5A (eIF5A), and its homolog eIF5A2.

162 fined by a long residence time of eukaryotic initiation factor 5B (eIF5B) on the 80S ribosome after t

163 itiation via an interaction with translation initiation factor 5B (eIF5B).

164 lled by the G-protein eukaryotic translation initiation factor 5B (eIF5B).

165 Eukaryotic translation initiation factor 6 (eIF6) is essential for the synthesi

166 in kinase R (PKR) and eukaryotic translation initiation factor alpha (eIF2alpha) phosphorylation earl

167 ticulum kinase (PERK)-eukaryotic translation initiation factor alpha (eIF2alpha)-CEBP homologous prot

168 elevated phosphorylation of the translation initiation factor alpha subunit of eukaryotic initiation

169 ncreased levels of phosphorylated eukaryotic initiation factor alpha, which was required for C. burne

170 oteins identified, Cdc6 is a DNA replication initiation factor and exhibits oncogenic activities when

171 n complexes have revealed that the ribosome, initiation factors and fMet-tRNA(fMet) can acquire diffe

172 nding of the rearrangements to the ribosome, initiation factors and fMet-tRNA(fMet) that occur during

173 n detected on several eukaryotic translation initiation factors and ribosomal proteins.

174 5' upstream open reading frames, translation initiation factors, and primary and secondary structures

175 l component that ensures stable anchoring of initiation factors, and thus the polymerase itself, in t

176 WDHD1 may also function as a DNA replication initiation factor as well as a G1 checkpoint regulator.

177 selection is regulated by many trans-acting initiation factors as well as sequence/structural elemen

178 Notably, detection of translation initiation factors at the RTC was instrumental to visual

179 nce and strict requirement of the additional initiation factor Bdp1 in the RNA polymerase (RNAP) III

180 resulted in increased ribosomal proteins and initiation factors, but decreased levels of proteins inv

181 (PABPs) link mRNA 3' termini to translation initiation factors, but they also play key roles in mRNA

182 t that the reduced activity of a translation initiation factor called eIF2alpha might be partly respo

183 S elongation-competent complex formed via an initiation-factor-catalysed reaction has precluded an un

184 ic proteins, including the three cytokinesis initiation factors CIF1, CIF2, and CIF3.

185 the eIF4E/eIF4G subunits of the translation initiation factor complex eIF4F is a hallmark of cancer.

186 h is regulated by the formation of a ternary initiation factor complex involving eIF4E, eIF4G, and eI

187 The increase in these ternary initiation factor complex proteins was associated with e

188 tion stage by competing with the cap-binding initiation factor complex, eIF4F, restricting infection

189 These models allow us to locate PTMs within initiation factor complexes and to highlight possible ro

190 nd demonstrated co-translational assembly of initiation factor complexes.

191 g proteins but none of the major translation initiation factors, consistent with a function in preven

192 Thus, DHX29 is another example of an initiation factor contributing to start codon selection.

193 itor cell population can contribute to tumor initiation, factors contributing to this malignant trans

194 The non-canonical initiation factor DENR promotes translation reinitiation

195 changes drive and regulate subunit joining, initiation factor dissociation and fMet-tRNA(fMet) posit

196 endent degradation of a limiting replication initiation factor Drf1.

197 The heterotrimeric eukaryotic translation initiation factor (eIF) 2 plays critical roles in delive

198 thesis via phosphorylation of the eukaryotic initiation factor (eIF) 2alpha and thereby induce the IS

199 is triggered by both eukaryotic translation initiation factor (eIF) 2alpha phosphorylation and eIF4F

200 Eukaryotic initiation factor (eIF) 3j is a subunit of eIF3 that bin

201 n kinase interacting kinase (MNK) eukaryotic initiation factor (eIF) 4E pathways.

202 TE or BTE) that binds eukaryotic translation initiation factor (eIF) 4F and recruits 40S ribosomal su

203 rgently signal to the eukaryotic translation initiation factor (eIF) 4F complex to regulate the sensi

204 been directed towards inhibiting eukaryotic initiation factor (eIF) 4F-dependent translation.

205 r ability to bind directly to the eukaryotic initiation factor (eIF) 4G component of the eIF4F cap-bi

206 The eukaryotic translation initiation factor (eIF) 4G is required during protein sy

207 t) in a ternary complex (TC) with eukaryotic initiation factor (eIF)2-GTP scans the mRNA leader for a

208 Phosphorylation of the translation initiation factor eIF2 alpha at a conserved serine resid

209 is of proteins controlled by the translation initiation factor eIF2(11).

210 of the heterotrimeric eukaryotic translation initiation factor eIF2, cause MEHMO syndrome, an X-linke

211 g the function of the eukaryotic translation initiation factor eIF2-eIF2B complex, reversed the chang

212 synthesis by phosphorylation of translation initiation factor eIF2.

213 rylation of the alpha-subunit of translation initiation factor eIF2.

214 4) and phosphorylated eukaryotic translation initiation factor eIF2.

215 y phosphorylation of the general translation initiation factor eIF2.

216 Conversely, the alternative initiation factor eIF2A is essential for cancer progress

217 146 precludes phosphorylation of translation initiation factor eIF2alpha (alpha subunit of eukaryotic

218 ontrol by phosphorylation of the translation initiation factor eIF2alpha (p-eIF2alpha) accounts for a

219 Phosphorylation of the translation initiation factor eIF2alpha anchors a reversible regulat

220 und that reduced activity of the translation initiation factor eIF2alpha underlies the hypersensitivi

221 controls phosphorylation of the translation initiation factor eIF2alpha via the unfolded protein res

222 Phosphorylation of the translation initiation factor eIF2alpha within the mediobasal hypoth

223 , different kinases phosphorylate eukaryotic initiation factor eIF2alpha, enabling the translation of

224 ressible 2 (GCN2) phosphorylates translation initiation factor eIF2alpha, initiating the integrated s

225 mprising the kinase PERK and the translation initiation factor eIF2alpha, is a pathological feature o

226 ction induces phosphorylation of translation initiation factor eIF2alpha, which promotes the formatio

227 ation via phosphorylation of the translation initiation factor eIF2alpha.

228 TF4 in response to inhibition of translation initiation factor eIF2B.

229 y enhances the dependence on the translation initiation factor eIF2B5.

230 ors of such ATF4 induction, the noncanonical initiation factors eIF2D and DENR.

231 EIF3C, a subunit of the protein translation initiation factor EIF3, as the direct target of the YTHD

232 hown to interact with eukaryotic translation initiation factor eIF3, in termination.

233 omain protein and the eukaryotic translation initiation factor eIF3b.

234 bition of eIF4F complex, an amalgam of three initiation factors, eIF4A, eIF4G, and eIF4E, by the chem

235 the expression of the eukaryotic translation initiation factor EIF4A1, the tumor suppressor gene PTEN

236 f mTORC1 and its downstream mRNA translation initiation factors eIF4B and 4EBP1, as well as elevated

237 for RNAs to bind the eukaryotic translation initiation factor eIF4E and associate with the translati

238 pported by the localization of a translation initiation factor eIF4E and by ribosome-bound nascent ch

239 oy conditional overexpression of translation initiation factor eIF4E to increase protein synthesis in

240 ogeneity for interactions of the translation initiation factor eIF4E with the universal mRNA 5' cap s

241 We show that the eukaryotic translation initiation factor eIF4E, an oncoprotein, drives HA biosy

242 ome biogenesis genes and the key translation initiation factor eIF4E.

243 ion by modulating the binding of translation initiation factors eIF4E and eIF4G to p63alpha mRNA.

244 e cap-binding protein eukaryotic translation initiation factor (eIF4E) is enhanced.

245 known to show high levels of the eukaryotic initiation factor, eIF4E, a potent oncogene.

246 allows the virus to usurp a host translation initiation factor, eIF4E, in a way that differs from hos

247 ctivity of the m(7)G cap-binding translation initiation factor, eIF4E, respectively.

248 utations in the plant eukaryotic translation initiation factors, eIF4E and eIF4G or their isoforms.

249 its ability to compete with the translation initiation factor eIF4F to specifically recognize foreig

250 cing, interacts with the general translation initiation factor eIF4G and promotes translation of a su

251 region that interacts with host translation initiation factor eIF4G.

252 in the absence of the kl-TSS by sequestering initiation factor eIF4G.

253 DAC), mutant KRAS stimulates the translation initiation factor eIF5A and upregulates the focal adhesi

254 Eukaryotic translation initiation factor eIF5A promotes protein synthesis by re

255 ing of the 40S ribosomal subunit, eukaryotic initiation factors (eIFs) and initiator tRNA scans mRNA

256 o latency are sequestration of transcription initiation factors, establishment of epigenetic barriers

257 ion homologous to the yeast Sld2 replication initiation factor, followed by a cysteine-rich region, p

258 Initiation factor (IF) 2 controls the fidelity of transl

259 uL6 and rRNA helix H69, which interact with initiation-factor IF2, interferes with proper protein sy

260 In bacterial translational initiation, three initiation factors (IFs 1-3) enable the selection of ini

261 We summarize the knowledge regarding the initiation factors implicated in this activity as well a

262 ore, our results define eIF4A as a universal initiation factor in cap-dependent translation initiatio

263 However, the exact roles of these initiation factors in assembly of the replication fork h

264 ve implicated aberrant levels of translation initiation factors in cancer etiology and provided evide

265 correlated with insertions in translational initiation factors in fidelity-determining regions that

266 therapy resistance, require the translation initiation factor initiation elongation factor alpha (eI

267 onents, RNA association was most reduced for initiation factors involved in 40S scanning (eukaryotic

268 Consequently, this essential translation initiation factor is nearly twice as abundant in male as

269 The Escherichia coli sigma70 initiation factor is required for a post-initiation, pro

270 alpha (P-eIF2alpha), a conserved translation initiation factor, is clock controlled in Neurospora cra

271 f1 and TFB2M proteins serve as transcription initiation factors of mitochondrial RNA polymerases in S

272 nduced progressive loss of 5' RNA binding by initiation factors over ~16 min and provoked mRNA degrad

273 In eukaryotic cells, numerous translation initiation factors prepare ribosomes for polypeptide syn

274 wever, the precise molecular details for how initiation factors regulate mRNA accommodation into the

275 Binding of initiation factor Rrn3 activates Pol I, fostering recrui

276 the RNA polymerase I-specific transcription initiation factor RRN3, were up-regulated after SIRT1 in

277 We show that mutation in the region 1.2 of initiation factor sigma decreases sensitivity to Urd.

278 knockdown of BRF1 RNA pol III transcription initiation factor subunit (BRF1) enhanced HCC cell sensi

279 encodes an RNA polymerase III transcription initiation factor subunit for further analysis, based on

280 Mitochondrial RNA polymerases depend on initiation factors, such as TFB2M in humans and Mtf1 in

281 ate DNA replication by degrading replication initiation factors, suggesting a model in which Pim1 act

282 ents facilitate recruitment of the essential initiation factors TATA-binding protein and transcriptio

283 s transcribed by POLRMT with the help of two initiation factors, TFAM and TFB2M.

284 The archaeal initiation factor TFE and its eukaryotic counterpart TFI

285 ow that Rap94 partially resembles the Pol II initiation factor TFIIB, that the vRNAP subunit Rpo30 re

286 Time-course experiments showed that initiation factor TFIIF can remain bound to early ECs, w

287 cyclin H) kinase module of the transcription initiation factor TFIIH.

288 e of a flexible element in the transcription initiation factor that engages the DNA template for RNA

289 PLE encodes a RepA_N initiation factor that is sufficient to drive replicatio

290 uron-specific microexon in eIF4G translation initiation factors that dampens synaptic protein transla

291 ryotes requires the interplay of at least 10 initiation factors that interact at the different steps

292 Here we define the critical sequence and initiation factors that mediate CGG repeat RAN translati

293 promoter and interacts with two other Pol I initiation factors, the TATA-binding protein (TBP) and c

294 d chromatin immunoprecipitation (PIP-seq) of initiation factors to identify the precise location of m

295 ved catalytic core of the RNAP combines with initiation factors to locate promoter DNA, unwind 12-14

296 ar to improve the recruitment of translation initiation factors to the target mRNA.

297 yotic initiation factor 2 (eIF2) translation initiation factor upon binding to viral double-stranded

298 teriophage satellites, expression of the PLE initiation factor was not sufficient for PLE replication

299 on factor eIF5A, originally identified as an initiation factor, was later shown to promote translatio

300 of the 70S initiation complex is promoted by initiation factors, which must dissociate from the 30S i