ライフサイエンスコーパス: innate immune response

1 d hAT2 cells, indicating a robust endogenous innate immune response.

2 ed in apoptosis, mitochondrial dynamics, and innate immune response.

3 d therefore may increase the efficacy of the innate immune response.

4 antibody-mediated adaptive and cell-mediated innate immune response.

5 receptors (TLRs) play a crucial role in the innate immune response.

6 zation of the ontogenetic development of the innate immune response.

7 ant for the regulation and implementation of innate immune response.

8 standing of viral RNA functions and the host innate immune response.

9 so modify the host environment to disarm the innate immune response.

10 ted that RVVC might be due to a dysregulated innate immune response.

11 e of estradiol, mainly by attenuation of the innate immune response.

12 naling pathways, including antagonism of the innate immune response.

13 eover, infection does not provoke an obvious innate immune response.

14 proinflammatory cytokines to orchestrate an innate immune response.

15 proteins and represents a key player in the innate immune response.

16 in microglia that are not associated with an innate immune response.

17 ry syndrome results from a dysregulated host innate immune response.

18 s lipid A, which potently activates the host innate immune response.

19 l immune activation can dysregulate PU.1 and innate immune response.

20 virus replication and/or by stimulating the innate immune response.

21 n macrophages, an essential component of the innate immune response.

22 s of translation-blocking morpholinos on the innate immune response.

23 e and secrete specific miRNAs and elicits an innate immune response.

24 how iron sequestration as a component of the innate immune response.

25 interferons (IFNs) are key mediators of the innate immune response.

26 ein of IAV is an important antagonist of the innate immune response.

27 ellular pathogen products and initialize the innate immune response.

28 ce, suggesting a role for TLR sensing in the innate immune response.

29 eliminate the danger signal and inhibit the innate immune response.

30 ing activities is required for PARPi-induced innate immune response.

31 (Lpro) affects several pathways of the host innate immune response.

32 e represent the first line of defense of the innate immune response.

33 gnals, particularly in cells involved in the innate immune response.

34 of this fungal PAMP to the activation of an innate immune response.

35 duction of glycolysis required for efficient innate immune responses.

36 ress, including oxidative stress, as well as innate immune responses.

37 derived dsRNA as danger signals and initiate innate immune responses.

38 nt role for MARCH2 in homeostatic control of innate immune responses.

39 itis B virus (HBV) has the ability to induce innate immune responses.

40 rom microorganisms are powerful triggers for innate immune responses.

41 antimicrobial activity has been reported in innate immune responses.

42 olesterol biosynthetic pathway to facilitate innate immune responses.

43 o sites of tissue infection is a hallmark of innate immune responses.

44 llular viral intermediates known to activate innate immune responses.

45 film accumulation, and reprogramming of host innate immune responses.

46 cantly potentiate ionizing radiation-induced innate immune responses.

47 ammatory cascades dominantly governed by the innate immune responses.

48 where it is protected from host cytoplasmic innate immune responses.

49 tly targeting viral components or modulating innate immune responses.

50 l genes required to counteract intrinsic and innate immune responses.

51 st cells are crucial factors in induction of innate immune responses.

52 ary response gene 88) family, which mediates innate immune responses.

53 pattern recognition receptors that initiate innate immune responses.

54 f P. gingivalis 33277 to stimulate host cell innate immune responses.

55 to alarmins and neuropeptides during type 2 innate immune responses.

56 equired for the effective activation of host innate immune responses.

57 ein-protein interface crucial for initiating innate immune responses.

58 lso play critical roles in the regulation of innate immune responses.

59 ial organization of phagocytic receptors and innate immune responses.

60 G) pathway detects cytosolic DNA to activate innate immune responses.

61 terfere with virus replication and stimulate innate immune responses.

62 ic activity of lysozyme, virulence, and host innate immune responses.

63 ic naivete of the host population, and muted innate immune responses.

64 the biology of the intestinal epithelium and innate immune responses.

65 ys a crucial role as a negative regulator of innate immune responses.

66 of programmed cell death, inflammation, and innate immune responses.

67 receptors have pivotal roles in shaping host innate immune responses(1,5).

68 c acids derived from pathogens induce potent innate immune responses(1-6).

69 e that Tnfa is a major driver for persistent innate immune responses after allogeneic cells.

70 tory cell death mechanism that underpins the innate immune response against pathogens and is dysregul

71 lying the evasion of the macrophage-mediated innate immune response against S. aureus infection assoc

72 o) iNKT1 cells play a role in the protective innate immune response against symptomatic ocular herpes

73 l that is effective but does not activate an innate immune response against the drug-TNF complex.

74 Despite its critical role in the innate immune response against urinary tract infections,

75 nces in our understanding of cell autonomous innate immune responses against bacterial pathogens, and

76 -G/AMP (cGAMP) synthase (cGAS) triggers host innate immune responses against cytosolic double-strande

77 suggests that cholesterol metabolism impacts innate immune responses against infection.

78 tal for sensing cytosolic DNA and initiating innate immune responses against microbial infection and

79 sents the initial step for the activation of innate immune responses against pathogens in the airways

80 ing and thawing or a chemical inducer of the innate immune response all induced a similar regional ac

81 Thus, NopA is an important regulator of the innate immune response allowing Coxiella to behave as a

82 y Lrch4 as a broad-spanning regulator of the innate immune response and a potential molecular target

83 lial disease from SARS-CoV-2 by reducing the innate immune response and ABSC proliferation and has im

84 g cancer cells have the potential to amplify innate immune response and activate antitumor adaptive r

85 s unveil a novel tRNA-engaged pathway in the innate immune response and assign the role of "immune ac

86 ation of emergency granulopoiesis during the innate immune response and contributes to leukemogenesis

87 This in turn triggers an innate immune response and drives cell division independ

88 hypothesized to help these viruses evade the innate immune response and establish infections in their

89 Because TREM2 plays a role in the innate immune response and has been associated with deme

90 lication stress modulates the cell-intrinsic innate immune response and highlight the integration of

91 DNA damage activates the innate immune response and improves ICB efficacy.

92 t in murine xenogeneic model, activating the innate immune response and increasing tumor infiltrating

93 on factor NF-kB is a master regulator of the innate immune response and plays a central role in infla

94 actions between influenza virus and the host innate immune response and reveal a new function for PAR

95 EIF2AK2 is also involved in innate immune response and the regulation of signal tran

96 T signaling to help the virus evade the host innate immune response and, thus, causes resistance to I

97 cle, Chlamydia must evade both intracellular innate immune responses and adaptive cytotoxic T cell re

98 Moreover, transient activation of innate immune responses and downregulation of humoral im

99 ght regulation of NEMO is essential for host innate immune responses and for maintenance of homeostas

100 ding in a recombinant ZIKV leads to enhanced innate immune responses and impaired growth kinetics.

101 G), have nonspecific effects, which modulate innate immune responses and lead to protection against m

102 ecurrent prostatitis develops despite strong innate immune responses and may be the result of a failu

103 that effectively targets adaptive as well as innate immune responses and may therefore enable cell th

104 study reveals a critical role of Hv1 during innate immune responses and places this channel as a key

105 ern recognition receptor that modulates host innate immune responses and protects from inflammation,

106 es the use of RU.521 for probing DNA-induced innate immune responses and underscores its potential as

107 tion A117V in ZIKV NS2A protein reduces host innate immune responses and viral-induced apoptosis in v

108 hanges in the complement cascade, lysosomes, innate immune response, and glycosaminoglycan metabolism

109 on the renin-angiotensin system, the body's innate immune response, and the vascular response to cyt

110 use several mechanisms to modulate the host innate immune response, and these likely contribute to t

111 ibutions to multidrug efflux, suppression of innate immune responses, and virulence.

112 Indicators of the neonatal innate immune response are associated with risk of ASD,

113 Peripheral inflammation and the innate immune response are elevated in DS.

114 ch are responsible for the generation of the innate immune response are still largely unknown.

115 Bacterial avoidance and innate immune response are two ways by which C. elegans

116 Stroma events including innate immune responses are key in cancer progression.

117 The data suggested that hematopoietic and innate immune responses are shaped by a preceding MI.

118 d mice deficient in select genes involved in innate immune responses are susceptible to persistent in

119 Macrophages, an important component of the innate immune response, are a key regulator of intestina

120 has led to great interest in harnessing the innate immune response as a therapeutic strategy to trea

121 Moreover, we identify an exuberant innate immune response as key player in pathogenesis, in

122 dotA::Tn mutant strain present a functional innate immune response, as opposed to cells exposed to w

123 ecognized as modulators of both adaptive and innate immune responses, as well as players in an import

124 new insight into the benefits of a tailored innate immune response at the intestinal barrier and sug

125 s, which highlighted the importance of early innate immune responses at inhibiting virus spread.IMPOR

126 This study investigated bidirectional innate immune responses between the injured brain and lu

127 irus genomes (DVGs) are powerful inducers of innate immune responses both in vitro and in vivo They i

128 terial/viral infection, along with increased innate immune responses both in vitro and in vivo.

129 The inflammasome is integral to innate immune responses but over-activation has been des

130 to trap and neutralize pathogens during the innate immune response, but also form in and exacerbate

131 s are recognized as an essential part of the innate immune response, but an active debate still exist

132 lating CpG ODN and cGAMP induced synergistic innate immune response by elevating type I and type II i

133 viral RNA in the cytosol and initiates host innate immune response by triggering the production of t

134 iral mimicry in which treated cells mount an innate immune response by turning on viral defence genes

135 chanistically, we show that acetate enhances innate immune responses by acting on both neutrophils an

136 Expressed alone, W modulates innate immune responses by several mechanisms, and elimi

137 nvenient method by which respiratory mucosal innate immune responses can be measured.

138 We further discuss how innate immune responses can be players of the organismal

139 Viral infections trigger host innate immune responses, characterized by the production

140 The degree to which the innate immune response confers protection or induces pat

141 xt BC200 suppressed translation; however, an innate immune response confounded the data.

142 Adaptive as well as innate immune responses contribute to the development of

143 ' PARP1 degraders to avoid the activation of innate immune response could be useful in non-oncologica

144 ion of host genes related to translation and innate immune response could contribute to differential

145 nteractions between viruses and the cellular innate immune response could enable the development of t

146 ines were greatly decreased, including early innate immune responses critical to disease development

147 secretion system (T4SS) to silence the host innate immune response during infection.

148 endogenous dsRNA formation and a deleterious innate immune response during mammalian hematopoietic de

149 or as an important regulator of IFN-a-driven innate immune responses during HIV infection.

150 , participate in the induction of protective innate immune responses during invasive aspergillosis.

151 hort peptides that are key components of the innate immune response, exhibit antiviral activity again

152 tion model to address the hypothesis that an innate immune response fails to develop following prosta

153 ematode worm Caenorhabditis elegans triggers innate immune responses following infection with numerou

154 gnificantly increased, whereas expression of innate immune response genes are significantly decreased

155 ta analysis revealed extensive regulation of innate immune response genes following PQ ingestion.

156 ates viral replication, gene expression, and innate immune responses.IMPORTANCE Coronaviruses (CoVs)

157 new negative and intrinsic regulator of the innate immune response in breast tumor cells, and ZMYND8

158 This study establishes a new paradigm in innate immune response in chronic ethanol consumers.

159 otentially functioning as a potent antiviral innate immune response in DNA virus-infected cells.

160 One innate immune response in insects is the proteolytic act

161 supplementation blunted the induction of the innate immune response in melanoma cells.

162 on of ST2(+) T(reg) cells in suppressing the innate immune response in the lung to environmental alle

163 t how macrophages fit into the context of an innate immune response in whole animals with multiple ce

164 athogen recognition to prevent activation of innate immune responses in a sophisticated manner.IMPORT

165 SAMHD1, is important for its suppression of innate immune responses in differentiated monocytic cell

166 lity of NS1 from avian viruses to antagonize innate immune responses in human primary cells compared

167 Our understanding of innate immune responses in human rectal mucosal tissues

168 Given the crucial role of innate immune responses in immunity, harnessing these re

169 ng the activation, timing, and resolution of innate immune responses in macrophages.

170 hich could possibly affect the TLR-triggered innate immune responses in malaria patients.

171 In the current study, we studied different innate immune responses in mice with knockout (KO) of co

172 y as a regulator of TLR2-mediated protective innate immune responses in S aureus-induced endophthalmi

173 ns, suggesting an exclusive role of NCoR1 in innate immune responses in the brain.

174 rasite-sustained inflammation or deregulated innate immune responses in treatment failure.

175 Thus, A20 restricts CLR-induced innate immune responses in vivo and is a suppressor of h

176 these cells, fit into complex multicellular innate immune responses in vivo, providing important inf

177 oid system in the inhibition of MC-dependent innate immune responses in vivo.

178 hils (PMNs) from these KO mice had defective innate immune responses, including defective expression

179 Innate immune responses induced by our panel of IAV reco

180 The cellular innate immune responses induced in these cells upon infe

181 ew, we focus on our present understanding of innate immune responses, inflammasome activation, inflam

182 levels reflect little to no activation of an innate immune response, influence the differential diagn

183 tions between biological sex, the intestinal innate immune response, intestinal inflammation, and int

184 The innate immune response is active in invertebrate larvae

185 esults suggest that a major component of the innate immune response is antagonistic to the bactericid

186 The innate immune response is crucial for defense against vi

187 A major sensor of DNA that triggers the innate immune response is cyclic guanosine monophosphate

188 that the observed link between NRF2 and the innate immune response is not restricted to melanoma.

189 numbers within dystrophic muscle, or that an innate immune response is required for effective donor c

190 Although the innate immune response is typically beneficial, an exces

191 Suppression of innate immune responses is essential for the survival of

192 uggesting that SAMHD1-mediated inhibition of innate immune responses is independent of SAMHD1's nucle

193 of interferon genes (STING, TMEM173) in the innate immune response, its loss or impairment in cancer

194 scheme for understanding and controlling the innate immune response leading to long-term postviral lu

195 Nonclonal innate immune responses mediated by germ line-encoded re

196 ss of METTL3 and m(6)A activated an aberrant innate immune response, mediated by the formation of end

197 These innate immune responses might be targeted in the emergin

198 ne expression profiles consistent with local innate immune responses (monocyte and neutrophil activat

199 strate a defense mechanism for boosting host innate immune responses, namely effects of MC-derived IL

200 produced extracellular CDNs can regulate the innate immune response of barrier epithelial cells linin

201 vestigate the molecular underpinnings of the innate immune response of the larvae to the pathogen.

202 We studied the innate immune responses of TB case contacts to understan

203 This highlights that dysregulated innate immune responses of the nasal mucosa in allergic

204 odel of VaD to investigate its effect on the innate immune response-particularly the inflammasome sig

205 eveal a striking divergence in a fundamental innate immune response pathway in AMs and establish a fr

206 ome analysis, we found increased activity of innate immune response pathways and RTK signaling in bon

207 We further revealed tissue-specific innate immune response patterns to HCMV, comparing infec

208 demonstrating the likely critical role these innate immune responses play in early mucosal HIV replic

209 justifies a better understanding of the host innate immune response process that attenuates virus rep

210 at antimicrobial peptides, components of the innate immune response, protect the kidneys and bladder

211 Alterations in innate immune response proteins in early pregnancy are p

212 tealth virus, as it does not induce a strong innate immune response; rather, oxidative phosphorylatio

213 l-like receptor 2 (TLR2) plays a key role in innate immune response recognizing molecular patterns ex

214 Innate immune responses rely on rapid and precise gene r

215 persistent alteration of the microbiome and innate immune response resulting in increased susceptibi

216 sis is associated with enhanced heterologous innate immune responses similar to those activated durin

217 Furthermore, genes corresponding to the innate immune response such as RSAD2 and IFIH1 were stro

218 e demonstrate that CSE promotes an excessive innate immune response, suppresses the adaptive immune r

219 Several proteins in plants build up the innate immune response system in plants which get trigge

220 ceptor 4, an important mediator of the brain innate immune response that contributes to neuroinflamma

221 Antimicrobial peptides are components of innate immune response that have a key role on susceptib

222 y by engaging TRIM21, which mediates a rapid innate immune response that mobilizes the core autophagy

223 tivation of IFN signaling to direct a potent innate immune response that restricts dengue virus infec

224 Prior studies have identified specialized innate immune responses that are active in the intestina

225 hepatotoxicity of APAP triggers a cascade of innate immune responses that may exacerbate or limit the

226 data indicate that C6(-/-) mice have reduced innate immune responses that result in less organ injury

227 , they must first survive a series of robust innate immune responses that take place prior to, during

228 nsing cytosolic DNA, the enzyme cGAS induces innate immune responses that underpin anti-microbial def

229 ole for Nck1 and a specific activator of the innate immune response, the downstream interleukin recep

230 As part of the innate immune response, the host withholds metal micronu

231 cGAS phosphorylation and promotes antiviral innate immune responses, thereby potently restricting vi

232 tor 5 (TGR5), which are able to modulate the innate immune response through signaling pathways such a

233 Cytosolic DNA triggers innate immune responses through the activation of cyclic

234 ADAR1-dependent RNA editing induces aberrant innate immune responses through the double-stranded RNA

235 cal cytosolic DNA sensor that elicits robust innate immune responses through the production of the se

236 amage-associated endogenous molecules induce innate immune response, thus making sterile inflammation

237 Our results suggest that the innate immune response to an obligate cytosolic bacteria

238 in induction of the earliest aspects of the innate immune response to Aspergillus fumigatus.

239 nt of host defense through modulation of the innate immune response to bacterial lung infection by re

240 be targeted therapeutically to stimulate the innate immune response to better deal with infections.

241 terial pathoadaptation that dampens the host innate immune response to Chlamydia infection.

242 Also, the role of innate immune response to coronavirus infection and the

243 genes (STING) protein-a key regulator of the innate immune response to cytosolic DNA.

244 ished that the Amish environment affects the innate immune response to decrease asthma and atopy risk

245 , these data support the conclusion that the innate immune response to early postnatal LPS exposure a

246 ferentially uses fatty acids associated with innate immune response to esterify cholesterol, weakenin

247 nt monocyte/macrophage subpopulations on the innate immune response to hyperoxia.

248 aB is a critical transcription factor in the innate immune response to infection and in shaping adapt

249 in complexes that play key roles in the host innate immune response to infection and sterile insults.

250 solic foreign or damaged DNA to activate the innate immune response to infection, inflammatory diseas

251 ctivate programmed cell death pathways as an innate immune response to infection.

252 taphylococcus aureus (MRSA) and bolsters the innate immune response to infection.

253 served viral factors known to limit the host innate immune response to infection.

254 Macrophages are important in mounting an innate immune response to injury as well as in repair of

255 utrophils (PMNs) play a critical role in the innate immune response to invading pathogens.

256 kocytes, play an important role in the early innate immune response to Mycobacterium tuberculosis inf

257 oorganisms and serve as key receptors in the innate immune response to pathogens.

258 mmunotherapy approaches and coordinating the innate immune response to pathogens.

259 rapidly activated by IL-1beta as part of the innate immune response to produce IL-26 to kill extracel

260 Human neutrophils are critical for the innate immune response to S. aureus infection.

261 cells serve as early rapid responders in the innate immune response to self-derived autoantigens and

262 nstead, hemocytes play a role in relaying an innate immune response to the blood cell reservoir: thro

263 reatment for RABV requires understanding the innate immune response to the virus because early virus

264 insights into the mechanism for the distinct innate immune response to these highly pathogenic arenav

265 role of SIDT1 in dsRNA transport and in the innate immune response to viral infection is unclear.

266 IFN-beta is a key component of the innate immune response to viral infection.

267 ys an important and multifaceted role in the innate immune response to viral infection.

268 M family proteins play integral roles in the innate immune response to virus infection.

269 xpression of multiple genes important in the innate immune response to viruses.

270 define the contributions of each RLR in the innate immune response to WNV.

271 ion form a positive feedback loop to amplify innate immune responses to control viral infections by a

272 minates not only adaptive immunity, but also innate immune responses to dermatophytosis.

273 However, given that HSV-1 can overcome innate immune responses to establish lifelong latency th

274 Here, we investigate how excessive innate immune responses to H5N1 impair subsequent adapti

275 hanistic insights into the differential host innate immune responses to highly pathogenic arenavirus

276 nical cell-matrix interactions can drive the innate immune responses to infection; however, the molec

277 pattern recognition receptors (PRRs) trigger innate immune responses to invading pathogens.

278 Vitamin D metabolites support innate immune responses to Mycobacterium tuberculosis.

279 We compared mouse innate immune responses to N. caninum and T. gondii and

280 ink bacterial infection and NF-kappaB-driven innate immune responses to R-loop-dependent replication

281 e receptor 8 (TLR8) has an important role in innate immune responses to RNA viral infections, includi

282 -inducible TRIM21 as a negative regulator of innate immune responses to S Typhimurium and a previousl

283 racteristics that confer divergent host cell innate immune responses to these highly related P. gingi

284 SAMHD1 suppresses innate immune responses to viral infection and inflammat

285 n bone, how bacterial infection or resulting innate immune responses trigger changes in bone remodeli

286 Stimulation of NOD1 leads to a robust innate immune response via activation of the major trans

287 Likewise, modulation of the host innate immune response via bile acid-activated receptors

288 component of wheat, activate the intestine's innate immune response via toll-like receptor 4 (TLR4).

289 To examine the impact of pregnancy on innate immune responses, we inoculated immunocompetent p

290 Moreover, potent adaptive and innate immune responses were stimulated in the OMV-immun

291 ing emergency granulopoiesis, and normalized innate immune responses when combined with chemotherapy.

292 hypothesized to be driven by an overreacting innate immune response, where the complement system is a

293 es in the tumour samples are involved in the innate immune response, whereas the downregulated genes

294 The TLRs are part of the innate immune response which typically reacts to "classi

295 tion, thus connecting DNA damage to cellular innate immune response, which may contribute to human pa

296 mbers of the IL-1 family are associated with innate immune responses, which occur in acute inflammati

297 ed lung tissues show a massively upregulated innate immune response with signatures of nuclear factor

298 by mycoplasma components that stimulate the innate immune response with the same basic regulatory me

299 r results reveal a novel regulatory layer of innate immune responses, with a central role for metallo

300 steps of viral infection and the consequent innate immune responses within the natural complexity an