ライフサイエンスコーパス: innate immune system

1 e ontogenetically distinct components of the innate immune system.

2 Neutrophils are an essential part of the innate immune system.

3 he interactions of rickettsiae with the host innate immune system.

4 icrobials and protects the bacteria from the innate immune system.

5 ften described as antiviral receptors of the innate immune system.

6 ileged production of defense proteins of the innate immune system.

7 outer membrane potently activates the human innate immune system.

8 terns (i.e., DAMPs) to activate TLRs and the innate immune system.

9 graft implant against attack by the maternal innate immune system.

10 oncanonical role of viral DNA sensing in the innate immune system.

11 to avoid any possible interference with our innate immune system.

12 icrobial transmission to override the host's innate immune system.

13 of plasmin generation and a component of the innate immune system.

14 r (NK) cells are a critical component of the innate immune system.

15 ns is critical for understanding the complex innate immune system.

16 ysiology and modulation of the metazoan host innate immune system.

17 e include enhancing bacterial killing by the innate immune system.

18 e: Proteolysis is a key aspect of the lung's innate immune system.

19 wing the bacterium to evade detection by the innate immune system.

20 e alternative complement pathway (AP) of the innate immune system.

21 ng properties of the niche are shared by the innate immune system.

22 lly, the adjuvant in addition stimulates the innate immune system.

23 a microbe between two sentinel cells of the innate immune system.

24 interferon (IFNs) response as part of their innate immune system.

25 ant cell wall without activating the plant's innate immune system.

26 impaired cross-talk between the adaptive and innate immune system.

27 associated with several abnormalities of the innate immune system.

28 es of the TA polymers that interact with the innate immune system.

29 ently emerged as important regulators of the innate immune system.

30 process dictated by multiples cues from the innate immune system.

31 which are crucial viral sensors in the host innate immune system.

32 ke receptors (TLRs) are major players of the innate immune system.

33 ical entities caused by dysregulation in the innate immune system.

34 rent strategies to inhibit or avoid the host innate immune system.

35 sequenced belonged to the IgM isotype of the innate immune system.

36 and inflammation-generating component of the innate immune system.

37 ia integration of hemocytes generated by the innate immune system.

38 IL-1beta release is integral to the innate immune system.

39 ovars, and several inhibit activation of the innate immune system.

40 ions for the therapeutic manipulation of the innate immune system.

41 entify a critical role for LPA in regulating innate immune system.

42 the inflammatory response of the peripheral innate immune system.

43 hood, even in the conventionally memory-less innate immune system.

44 system, Inulin Acetate (InAc), activates the innate immune system.

45 e complement alternative pathway (AP) of the innate immune system.

46 ptors (TLR), which are key regulators of the innate immune system.

47 sed ragweed pollen (Ambrosia elatior) on the innate immune system.

48 is the interface between the fungus and the innate immune system.

49 mplications suggest altered responses of the innate immune system.

50 system constitutes an important part of the innate immune system.

51 ments that target specific components of the innate immune system.

52 e-independent function that is vital for the innate immune system.

53 ient and acute inflammatory responses of the innate immune system.

54 sable elements can lead to activation of the innate immune system.

55 ygenic disorders due to dysregulation of the innate immune system.

56 lammasomes are multiprotein complexes of the innate immune system.

57 destructive autoinflammatory response by the innate immune system.

58 a group of receptors that play roles in the innate immune system.

59 terplay between plant proteins and the human innate immune system.

60 lement system plays an important role in our innate immune system.

61 , and they are involved in the regulation of innate immune system.

62 ey to tumor detection and elimination by the innate immune system.

63 host, making it an important target for the innate immune system.

64 cting tumor cells with both the adaptive and innate immune systems.

65 n-associated molecular pattern recognized by innate immune systems.

66 pressing the cross talk between adaptive and innate immune systems.

67 during normal aerobic metabolism and by the innate immune systems.

68 mselves from infection through intracellular innate immune systems.

69 The sensing of viral nucleic acids by the innate immune system activates a potent antiviral respon

70 of mPGES-1-dependent PGE2 may be crucial for innate immune system activation during various IL-33 dri

71 In contrast, chronic innate immune system activation is typically associated

72 The innate immune system acts as the first line of defense a

73 s avoid detection by macrophage cells of the innate immune system after exhaustive inspection (>90 ho

74 nstrated profound activation of cells of the innate immune system after food challenge, including mon

75 ce to antimicrobial peptides, weapons of the innate immune system against infections.

76 Here, we describe a mechanism by which the innate immune system allows rapid quality check of absor

77 is a key antibacterial component of the host innate immune system and almost all bacterial species po

78 d macrophages represent critical arms of the innate immune system and are considered regulators and e

79 ulated genes (ISGs) form the backbone of the innate immune system and are important for limiting intr

80 Macrophages are part of the innate immune system and are present in every organ of t

81 nd metabolic branches of the enteroendocrine innate immune system and argue that this response may pl

82 inflammasome is a critical component of the innate immune system and can be activated in response to

83 been reported in recent years to augment the innate immune system and cell proliferation, which play

84 with activation of specific pathways of the innate immune system and changes to metabolic gene expre

85 immune profile dominated by mediators of the innate immune system and chemotactic signaling (interleu

86 immune profile dominated by mediators of the innate immune system and chemotactic signaling was assoc

87 receptor (TLR), leading to activation of the innate immune system and chronic inflammation.

88 ciprocal relationships between sleep and the innate immune system and considers the role of sleep in

89 Natural killer (NK) cells belong to the innate immune system and contribute to protecting the ho

90 (IFNs) are essential components of the host innate immune system and define first-line of defence ag

91 Trojan horse," concealing the virus from the innate immune system and delivering it to T cells via vi

92 attern (eDAMP) molecules, which activate the innate immune system and endothelium to an inflammatory,

93 cle vaccine (nanovaccine) that modulates the innate immune system and enhances adaptive immunity with

94 ggered acute elevation of transcripts in the innate immune system and growth factor signaling.

95 re activated, how infection is sensed by the innate immune system and how intracellular signalling sy

96 and whether signals released by cells of the innate immune system and in the blood of patients influe

97 oid-beta is accompanied by activation of the innate immune system and involves inflammasome-dependent

98 ng oligomerization domain 2), belongs to the innate immune system and is among others responsible for

99 ed signaling potently activates cells of the innate immune system and is subject to regulation at dif

100 We found that stimulation of the innate immune system and microglia/macrophage activation

101 of BDG can still be recognised by the host's innate immune system and persistent BDG antigenaemia, in

102 lement system is an intricate cascade of the innate immune system and plays a key role in microbial d

103 ial peptides (AMPs) are key effectors of the innate immune system and promising therapeutic agents.

104 Neutrophils are critical cells of the innate immune system and rapidly respond to tissue injur

105 t blockade immunotherapy (CBI) awakes a host innate immune system and reactivates cytotoxic T cells t

106 ion in hepatocytes is restricted by the host innate immune system and related intracellular signaling

107 nition of potential microbial threats by the innate immune system and subsequent licensed adaptive im

108 nt years, the inter-relationship between the innate immune system and the central nervous system (CNS

109 Neutrophils are important cells of the innate immune system and the major leukocyte subpopulati

110 findings highlight the interplay between the innate immune system and the viral genome in HCV control

111 derstand the fundamental organization of the innate immune system and to explore the molecular functi

112 rms, key RNA editing enzymes linked with the innate immune system and viral infections.

113 NK cells are part of the innate immune system, and are able to identify and kill

114 tes are a critical component of the cellular innate immune system, and can be subdivided into classic

115 ect itself from several aspects of the human innate immune system, and control its iron homeostasis.

116 R4) is a pattern recognition molecule of the innate immune system, and evidence suggests that it modu

117 ported effects in xenobiotic metabolism, the innate immune system, and glutamate-associated proteins

118 ociated molecular pattern recognition by the innate immune system, and how this may influence adaptiv

119 LYS is an important defence molecule of the innate immune system, and its overexpression can be a co

120 The relevance of the innate immune system, and monocytes in particular, has e

121 Phagocytic cells of the innate immune system appear to be ineffective at clearin

122 Whereas the innate immune system appears more activated, the adaptiv

123 s study, we demonstrate the microglia of the innate immune system are also affected and uncover the m

124 sponsible for T. denticola activation of the innate immune system are currently not well defined.

125 cine-rich repeat (NLR) proteins of the plant innate immune system are negatively regulated by the miR

126 responses involving the adaptive versus the innate immune system are observed at various stages of n

127 seful in the same way humoral, cellular, and innate immune systems are used to treat or prevent bacte

128 dritic cells (DCs), a vital component of the innate immune system, are considered to lack antigen spe

129 NK cells, lymphocytes of the innate immune system, are important for defense against

130 Neutrophils, the essential components of the innate immune system, are recruited in large numbers to

131 vation of toll-like receptors 2 and 4 of the innate immune system as well as the downstream inflammat

132 n TAM, facilitating the development of novel innate immune system-based therapies for brain tumors.

133 insight into changes that occur in the skin innate immune system between the perinatal and adult per

134 dence that mitochondrial dysfunction and the innate immune system both play a role in the pathophysio

135 flammatory response in key components of the innate immune system but also in intestinal epithelial c

136 degradation and thus to escape from the host innate immune system but little is known about its physi

137 phocytes contribute to the regulation of the innate immune system by participating in the secretion o

138 They use it as a nutrient or to evade the innate immune system by sialylating surface lipopolysacc

139 cquired immune system, but activation of the innate immune system can also result in enhanced respons

140 However, cells of the innate immune system can also sense their local microenv

141 Contrary to prior belief, innate immune systems can also provide forms of immune m

142 flammatory response elicited by the vascular innate immune system, causing activation of the coagulat

143 al sepsis, there is robust activation of the innate immune system, causing the appearance of proinfla

144 auses aberrant phenotypes in myeloid-lineage innate immune system cells, namely monocytes and macroph

145 The signaling organelles of the innate immune system consist of oligomeric protein compl

146 The plant innate immune system contains a limited NLR repertoire t

147 rent article, we tested whether the platelet innate immune system contributes to responses to oxPCCD3

148 compartments and are central players of the innate immune system, contributing to first-line defense

149 The mosquito's innate immune system controls both Plasmodium and bacter

150 ADCP, and understanding such limitations to innate immune system cytotoxic capacity will aid in the

151 The mammalian innate immune system deals with invading pathogens and s

152 elicidin LL-37 serves a critical role in the innate immune system defending bacterial infections.

153 encoding components of the interferon lambda innate immune system drive viral polymorphism.

154 Chronic activation of the innate immune system drives inflammation and contributes

155 immune activation (MIA) disrupts the central innate immune system during a critical neurodevelopmenta

156 discuss what is known about the role of the innate immune system during SARS-CoV-2 infection, sugges

157 The innate immune system employs multiple strategies to star

158 observations provide novel evidence that the innate immune system employs protective mechanisms aimed

159 The innate immune system fights infection with inflammasomes

160 ore complex microbial management role of the innate immune system for controlled accommodation of ben

161 can translocate to the spleen and prime the innate immune system for enhanced reactivity.

162 nitoring of the cytosolic compartment by the innate immune system for pathogen-encoded products or pa

163 s on the impact of CNS-resident cells of the innate immune system for the development of neurodegener

164 mediated process requiring activation of the innate immune system for the formation and growth of gal

165 on the protein-based interferon (IFN)-driven innate immune system for the same purpose.

166 Remyelination requires innate immune system function, but how exactly microglia

167 lectin on macrophages and other cells of the innate immune system, functions in response to pathogens

168 The innate immune system has been implicated in both AKI and

169 Although activation of the innate immune system has been linked to the behavioral a

170 The functional relevance of the innate immune system has not yet been dissected in P0106

171 The innate immune system has recently been shown to promote

172 This proves that the innate immune system has the ability to respond dynamica

173 le and cell membrane-bound components of the innate immune system, has defined roles in the pathophys

174 Recently, however, cells of the innate immune system have been shown to be capable of di

175 nate lymphoid cells) cell populations of the innate immune system have been shown to display long-ter

176 es, especially their interplay with the host innate immune system, have not been well investigated.

177 ty in a transgenic mouse model with lifelong innate immune system hyperactivation.

178 Long-term activation of the innate immune system impairs insulin secretion and actio

179 uted to the lower level of activation of the innate immune system.IMPORTANCE Compared to the 2014-15

180 ngs suggest that T. denticola stimulates the innate immune system in a TLR2-dependent fashion and tha

181 ner, with antistimulatory CPS activating the innate immune system in a weaker manner than prostimulat

182 creasing evidence implicating a role for the innate immune system in AD initiation and progression.

183 The role of the innate immune system in allergic contact dermatitis (ACD

184 ureus survival and the ability to escape the innate immune system in blood.

185 ed upregulation of various components of the innate immune system in both diseases, including inflamm

186 proteins suggests a functional role for the innate immune system in CAPN5-NIV pathogenesis.

187 acted impact of COVID-19 on the adaptive and innate immune system in COVID-19 convalescent patients.

188 of inflammatory signaling molecules and the innate immune system in directing brain masculinization,

189 e novel insight into the broader role of the innate immune system in neurodegenerative disease.

190 effects that lentiviral infection has on the innate immune system in oral tissues of infected childre

191 ration, thereby underscoring the role of the innate immune system in PD pathogenesis.

192 nt advances in understanding the role of the innate immune system in the pathogenesis of ACD, includi

193 ich together suggest a dominant role for the innate immune system in the pathogenesis of TBM-IRIS.

194 rstand how rotavirus interacts with the host innate immune system in the small intestine.

195 Antimicrobial peptides are components of the innate immune systems in animals and plants as natural d

196 ntraxin 3 (PTX3), a pivotal component of the innate immune system, in gout.

197 and interleukin-8, critical cytokines of the innate immune system, in the aqueous humor of patients u

198 2 (BD-2) and 3 (BD-3), which are part of the innate immune system, in the treatment of infected ische

199 The role of the innate immune system, including ISGs, in controlling ret

200 ntimicrobial peptides (AMPs) produced by the innate immune system, including remodeling of phospholip

201 through which the enteric nervous system and innate immune system integrate to promote rapid type 2 c

202 NA) and complement are key components of the innate immune system involved in the opsonization, phago

203 The innate immune system is a central player, in which the c

204 The innate immune system is activated in a number of degener

205 After a burn, the innate immune system is activated with subsequent immune

206 This work provides evidence that a primed innate immune system is an effective defense against ret

207 Activation of the innate immune system is associated with mutism, withdraw

208 Activation of the innate immune system is commonly associated with depress

209 The evolutionarily conserved innate immune system is considered to play a key role in

210 The innate immune system is dysregulated in depression; howe

211 In particular, the innate immune system is emerging as an important signali

212 on of microbes and damaged host cells by the innate immune system is essential for host defense again

213 The innate immune system is normally programmed for immediat

214 We show here that the innate immune system is not spared in A-T.

215 standing how the functional phenotype of the innate immune system is programmed has led to paradigm-s

216 The interaction of Candida albicans with the innate immune system is the key determinant of the patho

217 Activation of the innate immune system is thought to contribute to depress

218 The innate immune system is tightly regulated, as excessive

219 The innate immune system is vital to rapidly responding to p

220 These organisms possess an innate immune system largely conserved with that of huma

221 es are characterized by dysregulation of the innate immune system, leading to spontaneous inflammatio

222 rstanding how dysregulation of this powerful innate immune system leads to these human diseases.

223 The defense machinery provided by the host innate immune system limits IAV replication; however, to

224 Eosinophils are multifunctional cells of the innate immune system linked to allergic inflammation.

225 t the crossroads between pathogen clearance, innate immune system, matrix deposition, female fertilit

226 findings reveal a new mechanism by which the innate immune system may be co-opted to drive tumor prog

227 g complement proteins that are active in the innate immune system may confer risk for schizophrenia b

228 y of certain drugs to directly stimulate the innate immune system may contribute to generate drug-spe

229 eviously unrecognized mechanism by which the innate immune system measures foreign nucleic acid lengt

230 Thus, Cxcr4 is essential for an innate-immune-system-mediated defense response after cer

231 rovides a novel link between PQ exposure and innate immune system modulation underlying environmental

232 Several factors, including the innate immune system, mucus composition, and diet, have

233 As part of the innate immune system, myeloid cells have diverse roles i

234 r results associate an important part of the innate immune system, namely complement receptors, with

235 The ancestral innate immune system of lower organisms (e.g., Caenorhab

236 oxidants is an important cornerstone in the innate immune system of mammals.

237 The innate immune system of patients with Alzheimer's diseas

238 The innate immune system of plants recognizes microbial path

239 of gammaherpesvirus infection.IMPORTANCE The innate immune system of the host is critical for the res

240 nteractions of viral molecules with the host innate immune system play a pivotal role in determining

241 hils are an absolutely essential part of the innate immune system, playing an essential role in the c

242 The innate immune system plays a critical role in allograft

243 r signaling events, where the host cnidarian innate immune system plays a crucial role in recognition

244 The innate immune system plays diverse roles in health and d

245 The innate immune system protects against infections by init

246 The innate immune system protects cells against viral pathog

247 There is much interest in the role of innate immune system proteins (antimicrobial peptides) i

248 usly unexpected cytosolic LPS sensing of the innate immune system provides critical hints for host re

249 eptides (AMPs) are central components of the innate immune system providing protection against pathog

250 n genes) pathway mitigates activation of the innate immune system, quantifiable as increased interleu

251 The innate immune system recalls a challenge to adapt to a s

252 Self/non-self-discrimination by the innate immune system relies on germline-encoded, non-rea

253 report that natural killer (NK) cells of the innate immune system reside in the dentate gyrus neuroge

254 BACKGROUND & AIMS: The innate immune system responds not only to bacterial sign

255 which is particularly important for how our innate immune system responds to infection in the presen

256 However, little is known about how the innate immune system responds to SARS-CoV-2.

257 mplex syndrome associated with a maladaptive innate immune system response that leads to deleterious

258 The innate immune system senses microbial ligands through pa

259 The innate immune system senses viral infection through patt

260 The innate immune system serves as one of the first lines of

261 antagonistic antimicrobial activities of the innate immune system should provide insight into how cel

262 pro- and antiinflammatory alterations of the innate immune system, similar to those reported in sever

263 on understanding pathogen recognition by the innate immune system, specifically how the inflammasome

264 esults show that the reconfigured RdRP mouse innate immune system substantially reduced retroviral re

265 it against enzymatic attack through the host innate immune system, such as the cell wall hydrolase ly

266 also other pattern recognition receptors and innate immune systems, such as NLRP3 inflammasomes.

267 The complement cascade is a part of the innate immune system that acts primarily to remove patho

268 (NK) cells are cytotoxic lymphocytes of the innate immune system that are capable of killing virally

269 emodeling, as well as being sentinels of the innate immune system that can contribute to protective i

270 ages comprise a major component of the human innate immune system that is involved in maintaining hom

271 le (Clec4e), a C-type lectin receptor of the innate immune system that is strongly up-regulated in re

272 NLRX1 is a receptor of the innate immune system that is ubiquitously expressed and

273 inflammasome is a critical component of the innate immune system that leads to release of IL-1beta.

274 lammasomes are multiprotein complexes of the innate immune system that orchestrate development of inf

275 e complement system is an ancient arm of the innate immune system that plays important roles in patho

276 The NLRP3 inflammasome is a component of the innate immune system that processes interleukin (IL)-1be

277 uced by pattern-recognition receptors of the innate immune system that sense pathogen-derived nucleic

278 While best known for its role in the innate immune system, the TANK-binding kinase 1 (TBK1) i

279 Given the extraordinary robustness of the innate immune system, this ISG network may serve as a bl

280 that the diet may be directly regulating the innate immune system through an unknown mechanism.

281 e indicated that T. denticola stimulates the innate immune system through Toll-like receptor 2 (TLR2)

282 for TREM2 in regulating the response of the innate immune system to Abeta pathology.

283 em relies on antigen-presenting cells of the innate immune system to activate the T cell response.

284 Bacterial pathogens often subvert the innate immune system to establish a successful infection

285 Y. pestis actively inhibits the innate immune system to generate a noninflammatory envir

286 eptidoglycan (PG) is recognized by the human innate immune system to generate an appropriate response

287 resistance, and enhances the ability of the innate immune system to kill infecting bacteria.

288 microbial infections, which alerts the host innate immune system to mount a defense response.

289 peptides are short peptides secreted by the innate immune system to protect the host from pathogens.

290 for beta-(1,3)-glucan, is important for the innate immune system to recognize systemic fungal infect

291 g B. thetaiotaomicron strains stimulated the innate immune system to skew toward M1 macrophages and r

292 biochemical reaction events in the bacterial innate immune system to the ecology of bacteria and bact

293 ecognition of influenza A virus (IAV) by the innate immune system triggers pathways that restrict vir

294 ely how it relays nutritional signals to the innate immune system under specific physiological contex

295 The innate immune system uses pattern recognition receptors

296 ic xenogeneic GB; spider venom activated the innate immune system; venom increased blood monocytes an

297 acroglobulin (A2M), a major component of the innate immune system, was associated with cerebrospinal

298 ightly controlled proteolytic cascade in the innate immune system, which tags intruding pathogens and

299 ta, and theta defensins are effectors of the innate immune system with potent antibacterial, antivira

300 Mincle is a C-type lectin receptor of the innate immune system with the ability to sense pathogens